Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model 1 Challenge the future Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model W.M. Boon Dr. ir. J. F. Vermolen Prof. dr. ir. C. Vuik Dr. ir. J. H. Dubbeldam D. Koppenol, MSc
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Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model 1 Challenge the future Incorporation of Contracture Formation.
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Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
1Challenge the future
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical ModelW.M. Boon
Dr. ir. J. F. Vermolen Prof. dr. ir. C. Vuik Dr. ir. J. H. Dubbeldam D. Koppenol, MSc
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
2Challenge the future
Opzet
• Onderzoeksdoel• Biologisch proces• Wiskundig model
• Componenten• Contractie
• Resultaten• Conclusies & aanbevelingen
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
3Challenge the future
Onderzoeksdoel
• Wondgenezing• Vorming van nieuw weefsel
• Sterkte afhankelijk van de mate van isotropie• Samentrekking van het weefsel (contractie)
• Contractuur vorming• Modelleren van het volledige proces
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
4Challenge the future
Gebied
• Doorsnede huid• Wondgebied• 3 weken
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
5Challenge the future
Biologisch proces
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
6Challenge the future
Biologisch Proces
• Fibrine klont gevormd• Afbraak door tPA
• PDGF verspreidt via diffusie• Leukocyten arriveren• TGF-β wordt uitgescheden
• Chemoattractant• Fibroblasten arriveren
• Myofibroblasten• Celdeling
• Collageen productie• Contractie
Contractie
Fibroblasten en Myofibroblasten
PDGF
Leukocyten
tPA
Fibrine
TGF-β
Collageen
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
7Challenge the future
Wiskundig model
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model
8Challenge the future
Componenten: Cellen
• Discrete schijven• Receptoren
• Leukocyten• Bloedsomloop
• Fibroblasten en myofibroblasten• Omliggend gebied• Celdeling
• Beweging• Celdood
Incorporation of Contracture Formation during Dermal Wound Healing: a Mathematical Model