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12ST0153_Answers_Brochure_Vitamins_v6.indd 1 4/6/12 2:34 PM

Answers about vitamins and supplements begin here.The best way to get the daily requirement of essential vitamins is to eat a balanced diet that contains a variety of foods from the food guide pyramid. In addition to eating well, vitamins and supplements may help ensure your body gets all the nutrients it needs. Since these needs can vary depending on age, gender and other factors, such as pregnancy, we created this helpful guide to vitamins and supplements.

ContentsBeauty .....................................Page 3

Bones & joints .........................Page 8

Congnitive health ..................Page 18

Digestive health ....................Page 27

Heart health ..........................Page 31

Immune health ......................Page 38

Prenatal health ......................Page 43

Children’s health ...................Page 50

Menopause ...........................Page 56

What nutrients should I consider for promoting the health of my hair, skin and nails?We often appreciate and distinguish beauty based on an outer appearance, but much more can be said about beauty when keeping our inner health in mind. Vitamins, minerals and other key nutrients play a very important role in maintaining healthy hair, skin and nails — the outward representation of our “beauty” within.

Read on to learn how the following nutrients can help nourish and maintain the health of your hair, skin and nails.

• Alpha lipoic acid • Biotin • Green tea extract • Lycopene • Vitamin C • Vitamin D • Vitamin E

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12ST0153_Answers_Brochure_Vitamins_v6.indd 2-3 4/6/12 2:34 PM

Alpha lipoic acidAlpha lipoic acid (ALA) is another important antioxidant in the body. Not only does ALA fight against damaging free radicals, but it also helps to regenerate or recycle other key antioxidant nutrients, specifically vitamins C and E. The ability of ALA to regenerate other protective nutrients helps to enhance the antioxidant activity in the body and thus maintain healthy skin.3

BiotinBiotin — a member of the B vitamins — is involved in the maintenance of healthy hair, skin and nails. Individuals who are deficient in biotin may experience scaly skin, loss of hair and brittle nails. Individuals who are not meeting their daily need for biotin can choose a daily biotin supplement to promote the strength and health of their hair, skin and nails.9

Green tea extractGreen tea is an excellent source of antioxidants. Research suggests that the antioxidant compounds found in green tea may play a beneficial role in maintaining healthy skin, even in the presence of UV light from the sun.1,2 Consequently, green tea extract packed with antioxidants may be a helpful addition to your health regimen.

LycopeneLycopene is a carotenoid that plays a role throughout the body, including the liver, adrenal glands, lungs, prostate and skin. The intake of lycopene — through dietary sources like tomatoes and supplements — can be a great way to promote healthy skin.

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Vitamin CVitamin C is a key nutrient when it comes to skin health. Not only does it offer potent antioxidant activity in helping to protect the skin, it is also necessary for the formation of collagen — an important compound naturally found in the skin that helps maintain the elasticity and integrity of the skin.4,5,6

Vitamin DProtecting the skin through the use of sunscreen is essential when it comes to reducing the risk of cellular damage from UV light. Unfortunately, the use of sunscreen with an SPF of 15 or higher inhibits the skin’s ability to synthesize vitamin D — a critical nutrient involved in bone health and immune function, among other benefits. Thus, when protecting the skin by applying sunscreen, it is equally important to keep in mind alternative ways for ensuring adequate blood levels of vitamin D. Foods like salmon and fortified milk provide a moderate amount of vitamin D and can be a good way to meet your


Nutrient Suggested use

Lycopene 10 mg per day

Green tea extract 50-400 mg standardized extract per day

• Higher amounts may be taken under a doctor’s supervision, especially if deficiency is present

Vitamin D 1,000 -2,000 IU per day for adults

Alpha lipoic acid 50-400 mg per day

Up to 2,500 mg per dayBiotin

Vitamin C 250-500 mg per day

Vitamin E 200-400 IU per day

REMEMBER: Please consult with your doctor before beginning any dietary supplement program or for specific concerns regarding your health condition or prescription medication.

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requirement if you consume multiple servings of each per day. For the many people who don’t get enough vitamin D through the diet, taking a daily vitamin D supplement can be a great way to fulfill your need for this very important nutrient.8 Foods like salmon and fortified milk provide a moderate amount of vitamin D and can be a good way to meet your requirement if you consume multiple servings of each per day. For the many people who don’t get enough vitamin D through their diet, taking a daily vitamin D supplement can be a great way to fulfill your need for this very important nutrient.8

Vitamin EVitamin E is a crucial antioxidant nutrient found in every cell of the body and helps to protect and maintain the integrity of all cells, including skin cells. As a result, ensuring adequate vitamin E through the diet is vital for promoting cellular health and healthy skin.5,6,7

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How do I maintain healthy bones and joints?As we age, “wear and tear” on our joints from constant repetitive motion can contribute to joint problems and limit mobility.

Following an ideal diet can be a challenge at times, so consider starting a supplement program if you believe that it would be to your advantage. Dietary supplements can be a great way to support your nutritional needs by filling the nutrient gaps that may exist. Remember, it is important to speak with your preferred healthcare provider or registered dietitian about a supplement regimen for promoting bone and joint health.

Read on to learn how the following nutrients can promote healthy bones and strong joints:

• Calcium • Chondroitin • Glucosamine • Hyaluronic acid • Magnesium • Multivitamins • Omega-3 fatty acids • SAM-e

bones & joints

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bones & joints

CalciumCalcium is essential for maintaining bone density and, in fact, the vast majority of the body’s calcium — greater than 90 percent — is stored in bone. The daily recommended intake level for calcium is 1,000 mg per day. Calcium carbonate and calcium citrate are the two main forms found in dietary supplements. People who suffer from gastrointestinal conditions (i.e, acid reflux) may find calcium citrate to be easier on the stomach and better tolerated than calcium carbonate. Talk to your doctor about what formula is right for you.

ChondroitinChondroitin is a close “partner” of glucosamine when it comes to improving joint health. It is a naturally occurring nutrient found in the connective tissue of the body that helps maintain the structure and function of joint cartilage. Chondroitin lubricates and cushions the joints by creating a shock-absorbing space within the cartilage tissues. Not only does this action provide cushioning support, but it also helps protect cartilage from being broken down by enzymes. If you suffer from moderate-to-severe joint pain, a combined chondroitin and glucosamine supplement may promote the health of your joints. Consult your doctor to see if a combined chondroitin and glucosamine supplement may be right for you.

GlucosamineIf you are conscientious about the health of your joints, it is likely that you have already heard about glucosamine. Glucosamine is a basic building block for maintaining joint cartilage and the structural integrity of your joints. It also helps


bones & joints

others, a multivitamin may lack a needed nutrient or may not provide enough of a nutrient. In such cases, extra supplements may be necessary.

Omega-3 fatty acidsThe most important omega-3 fatty acids for your joints are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA and DHA have positive effects on health, including joint health. To get your dose of EPA and DHA, aim for at least two weekly servings of fatty fish like salmon, halibut, tuna and sardines. If you don’t eat much fish, taking a fish oil supplement can be of help.

SAM-eSAM-e (short for S-adenosylmethionine) is a naturally occurring molecule in the body that is commonly associated with brain health and mood. While mood support is definitely a benefit, SAM-e can also play a role in joint health. SAM-e stimulates the synthesis of proteoglycans, which are necessary for the growth and repair of cartilage. Healthy cartilage not only protects your joints, but is also needed to maintain joint comfort. SAM-e is a very delicate compound that reacts quickly in the presence of air and moisture. Look for a SAM-e product that is packaged in blister packs, which help promote product effectiveness by limiting environmental exposure. Also, make sure your SAM-e supplement is enteric-coated. An enteric-coated formula means that the product can travel through the stomach to the small intestine where it is best absorbed.

promote overall elasticity, flexibility and mobility of the joints. Preliminary studies have found glucosamine to be superior to placebos in promoting joint comfort and improved functionality amongst populations. If you suffer from moderate-to-severe joint pain, consult with your doctor about whether dietary supplementation with glucosamine may be right for you.

Hyaluronic acidEmerging research suggests that hyaluronic acid provides lubrication and cushioning for the joints. It is a natural component of cartilage and the synovial fluid of the joints, and helps reduce friction between cartilage and other joint tissue during movement.10

MagnesiumThe mineral magnesium may not come to mind with regard to bone health, but nearly 50 percent of the body’s supply of magnesium is found in bone. Of the 300 essential metabolic reactions in the body that depend on magnesium, the metabolism of bone is one of them. Magnesium is directly involved in the formation of bone and the maintenance of bone density, which can help in the prevention of fractures. If you think you might be at risk of low magnesium levels, talk to your doctor about taking a magnesium supplement.1,2,3

MultivitaminsA daily multivitamin contributes to your nutritional status by filling the vitamin and mineral gaps that may exist in your diet. A daily multivitamin may be sufficient for some people, but for

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Nutrient Suggested use Calcium and vitamin D Calcium: 1,000 mg per day for adults in at least two

divided doses

Vitamin D: 1,000-2,000 IU per day for adults• Higher amounts may be taken under a doctor’s supervision, especially if deficiency is present

SAM-e 400-1,200 mg per day

Magnesium

Glucosamine

Omega-3 fatty acids• Higher amounts may be taken under a doctor’s supervision

Hyaluronic acid 10 mg per day

Chondroitin 800 mg per day

250 mg per day500 mg of EPA/DHA per day

1,500 mg per day

• Dose varies for each individual. Talk to your doctor or preferred healthcare provider to determine your individual SAM-e dose.


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cognitive

How do I promote the health of my brain as I age? We hear about heart health, joint health and bone health, to name a few, but we do not often hear about brain health. As the control center of your body, the brain is a vital organ that manages thousands of processes and communication lines that keep your body functioning at its best.

As the population grows older, most people can expect to experience some degree of normal age-related cognitive decline. Cognitive decline due to aging can affect multiple aspects of cognition, including the ability to process information, concentrate, memorize and reason. The supplements listed have various roles in brain development and function throughout various life stages from birth to adulthood.

The nutrients discussed in this section include

• Acetyl-L-carnitine • B vitamins: folic acid and vitamin B12 • Choline • Multivitamins • N-acetyl-L-cysteine • Omega-3 fatty acids • SAM-e • Vitamin D

18 19

Acetyl-L-carnitineAcetyl-L-carnitine (known as ALCAR) is a compound that is important in the process of energy metabolism. Carnitine’s main role is transporting fatty acids in the cell, which is an important step in energy production.4 Most people receive sufficient amounts of carnitine to meet daily needs. If you think you may be at risk of low carnitine levels, talk to your doctor about taking a carnitine supplement.

B vitaminsB vitamins — particularly folic acid and vitamin B12 — help maintain healthy homocysteine levels in the body. This is important because high homocysteine levels have been associated with reduced scores on tests designed to measure cognitive function.3 While scientists are still studying the relationship between B vitamins and dementia, B vitamins are effective in helping to manage homocysteine levels.

CholineAlthough your body can manufacture choline, it is also necessary to obtain choline through your diet in order to get the amount your body needs to function optimally.

cognitive


20 21

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Choline is necessary for the production of acetylcholine, an important neurotransmitter involved in muscle control, memory and many other functions. It is also a component of cell membranes (the outer layer of the cell) and helps facilitate effective communication between cells. Food sources rich in choline include egg yolk, beef, brussels sprouts and broccoli.

MultivitaminsIf you currently take a daily multivitamin, you may be wondering, “Do I need additional supplements?” A daily multivitamin contributes to your nutritional status by filling the vitamin and mineral gaps that may exist in your diet. A daily multivitamin may be sufficient for some people, but for others a multivitamin may lack a needed nutrient or may not provide enough of a nutrient. In such cases, extra supplements may be necessary.

N-acetyl-L-cysteineN-acetyl-L-cysteine (known as NAC) provides the body with an important amino acid known as cysteine. The body needs cysteine to produce glutathione, a powerful antioxidant compound that helps minimize the effects of free radicals. Without enough cysteine, the body’s ability to synthesize glutathione is weakened leading to potentially uncontrolled free-radical damage. This damage can affect various parts of the body, including the brain.

Omega-3 fatty acidsThe most important omega-3 fatty acid for brain health is docosahexaenoic acid (DHA). DHA is the major polyunsaturated

cognitive

fatty acid found in the brain and is important for brain development and function.

Fatty fish like salmon, anchovies, sardines and halibut are some of the most potent sources of DHA. Most people do not eat enough servings of these fish in their usual diet, which is why a fish oil supplement can be beneficial. For vegetarian consumption, flaxseed oil provides an omega-3 fatty acid known as alpha-linolenic acid (ALA), which partly converts to DHA in the body. ALA is also found in walnuts, almonds, avocados and other plant-based foods and oils.

SAM-eSAM-e (short for S-adenosylmethionine) is a naturally occurring molecule found in every living cell of the body, and is commonly associated with healthy brain function and mood. Discovered over 30 years ago, SAM-e is best known for enhancing mood by promoting a healthy balance of brain neurotransmitters. Levels of SAM-e tend to decline with age, so taking a supplement that provides SAM-e can be beneficial for overall brain health and for individuals with mood health concerns.



Omega-3 fatty acidsEPA and DHA

SAM-e

500 mg of EPA/DHA per day for healthy individuals

1,000 mg of EPA/DHA per day for individuals withdocumented heart conditions

200-1,600 mg per day

200-400 mcg per day

Supplement doses usually range from 500-2,000 mg per day

Supplement doses usually range from 425-3,000 mg per day

Supplement doses usually range from 600-900 mg per day

• Recommended starting dose at 200 mg per day


Vitamin D

Acetyl-L-carnitine

N-acetyl-L-cysteine

Choline

1,000-2,000 IU per day for adults

Antioxidant vitamins:C and E

Vitamin C: 250-1,000 mg per dayVitamin E: 200-400 IU per day

B vitamins:folic acid and vitamin B12 25-1,000 mcg per day


22

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itive

Vitamin DVitamin D is very important for healthy brain function and development. In addition, emerging research suggests that low vitamin D levels may be correlated with low performance on cognitive tests.

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CONSUMER: Redeem only by purchasing the brand and size(s) indicated. May not be reproduced. Void if transferred to any person, firm, or group prior to store redemption. LIMIT ONE COUPON PER PURCHASE. RETAILER: Factor Nutrition Labs will reimburse you the face value of this coupon plus 8 cents handling in accordance with our redemption policy (copy available upon request). Consumer must pay any sales tax. Send all redeemed coupons to: Factor Nutrition, Mandlik & Rhodes, PO Box 490 Dept #1055, Tecate, CA 91980 Cash value: 1/100¢. Expires 5/1/13.

Coupon good only in USA for product/quantity indicated. LIMIT ONE COUPON PER HOUSEHOLD. Any other use constitutes fraud. Void if copied, transferred, sold, or where prohibited, restricted, or taxed. Consumer pays sales tax. Retailer: Quincy Bioscience will reimburse an authorized retailer of our product the face value of this coupon, plus 8¢ handling, if submitted in compliance with our redemption policy, available upon request. Mail to Quincy Bioscience, 301 South Westfield Road, Suite 200 Madison, WI 53717. Cash value of .001¢. 2012 Quincy Bioscience, LLC. Expires 5/1/13.

RETAILER: We will reimburse you the face value of this coupon plus 8¢ handling provided you and the consumer have complied with the terms of this offer. Invoices proving purchases of sufficient stock to cover presented coupons must be shown on request. Any other application may constitute fraud. Coupon void where prohibited, taxed or restricted. Consumer must pay any sales tax. Cash value .001¢. Reproduction of this coupon is expressly prohibited. Mail to: Natrol, Inmar Dept. # 47469, One Fawcett Drive, Del Rio, TX 78840. Expires 5/1/13.

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What nutrients can I take to promote strong digestive health?Healthy digestion is key when it comes to keeping your body well. When you eat, the process of digestion facilitates the absorption and transportation of the important nutrients in food and makes those nutrients available for the body to use for essential functions like energy production and bone development. In addition, proper digestive health is involved in preventing toxins and harmful waste products from building up in the body. Thus, it is critical that you do your best to maintain a well-functioning digestive system by eating well, staying hydrated and engaging in regular physical activity. In addition, certain nutritional supplements can also help promote good intestinal health and digestion.

Read on to learn how the following nutrients may help to support the health of your digestive system and your overall health:

• Multivitamin • Prebiotics • Probiotics • Vitamin D

digestive

Coupon void if altered, copied, sold, purchased, transferred, exchanged or where prohibited or restricted by law. CONSUMER: Limit one coupon per specified item(s) purchased. This coupon good only on product sizes and varieties indicated. RETAILER: ALCON LABORATORIES, INC. will reimburse you face value plus 8¢, if submitted in compliance with ALCON LABORATORIES, INC. Coupon Redemption Policy dated 12/15/11, available upon request. Consumer must pay sales tax. Good only in USA. Send coupons to ALCON CONSUMER DIVISION, CMS DEPARTMENT #00067, #1 FAWCETT DRIVE, DEL RIO, TEXAS 78840. Cash value 1/20 cent. Expires 5/1/13.




I-Caps® Lutein & Omega-3, 30 ct. Softgels

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MultivitaminsIndividuals with existing digestive concerns such as inflammatory bowel conditions, lactose intolerance and gluten sensitivity may be at risk of having low levels of certain nutrients. They may have issues with absorption, which can compromise their nutritional status, or they may limit their intake of certain foods, consequently limiting their intake of key nutrients. For example, people who cannot tolerate dairy products usually need to find alternative sources of calcium since milk is a primary source of this important bone-building mineral. Although additional measures may need to be taken, a complete multivitamin can be a great way to promote optimal nutrient status in the face of digestive complications. Talk to your healthcare professional about a formula that is most appropriate for you. Although additional measures may need to be taken, a complete multivitamin can be a great way to promote optimal nutrient status in the face of digestive complications. Talk to your healthcare professional about a formula that is most appropriate for you.

PrebioticsPrebiotics are nondigestible and nonabsorbable foods that promote the growth and/or activity of the beneficial probiotic bacteria in the intestinal tract. As a result, prebiotic ingredients also contribute to the health of the intestinal system by way of keeping probiotic organisms alive and well. Inulin and oligofructose — soluble fibers naturally found in a variety of fruits and vegetables, such as bananas, yams, chicory root, garlic and leeks — have been classified as prebiotic ingredients based on their ability to resist digestion

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and absorption in the digestive tract and promote the growth of friendly bacteria. Individuals who may limit their intake of soluble fibers can choose a supplement that contains prebiotic ingredients.1,2

ProbioticsProbiotics are live microorganisms — primarily bacteria — that offer a health benefit to the human body. They are often referred to as “good” or “friendly” bacteria based on their beneficial activity in the intestinal tract.

Under normal conditions, the human digestive tract is home to a variety of bacteria — some “friendly” and some “unfriendly.” The lactic-acid producing bacteria, including the Lactobacillus and Bifidobacterium species, have been found to benefit the intestinal environment and support healthy digestion and nutrient absorption. Unfortunately, the presence and activity of “unfriendly” bacteria can sometimes wreck havoc on intestinal balance and lead to diarrhea and other digestive disturbances. To maintain healthy digestion, consumption of probiotic ingredients may help.

When it comes to dietary sources, yogurt and fermented foods like miso and tempeh are recommended because they contain naturally occurring live bacteria. If these items aren’t a part of your regular diet, dietary supplements containing live probiotic ingredients are an equally great way to restore and maintain a healthy intestinal environment and promote optimal digestive health and nutrition.1,2

digestive





Up to 2,500 mg per dayMultivitamin

Probiotic Follow the label instructions and talk to your doctor aboutthe probiotic that is right for you.

Prebiotic Follow the label instructions and talk to your doctor aboutincorporating prebiotic ingredients into your diet,particularly when following a probiotic regimen.


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Vitamin DThe rise of vitamin D inadequacy among Americans has prompted researchers to explore additional areas of health that may be affected by vitamin D insufficiency. The area of intestinal health, specifically colon health, is one that has received much attention. In fact, published studies have found an inverse relationship between blood levels of vitamin D and the risk of colon-related health concerns. As a result, the healthcare professional community encourages patients to have their vitamin D levels tested and to ensure adequate vitamin D status through fortified foods, nutritional supplements and safe sun exposure. A daily vitamin D supplement can be a great way to promote optimal intestinal health.3,4

How do I take care of my heart? The heart is needed to deliver oxygen to the muscles and transport essential nutrients to your cells. If the heart is damaged, its ability to carry out these roles and responsibilities may decline.

Engaging in regular physical exercise and eating a nutritious diet are factors you can control when promoting a healthy heart. Following an ideal diet can be a challenge at times, so you may want to consider starting an appropriate supplement program. Dietary supplements can be a great way to support your nutritional needs by filling the nutrient gaps that may exist.

The nutrients discussed in this booklet include

• Coenzyme Q10 • Multivitamins • Omega-3 fatty acids • Plant sterols and stanols

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Coenzyme Q10CoQ10 is an antioxidant and is required for proper function of many organs and chemical reactions in the body, including the heart. Free radicals are compounds that can harm your cells and negatively impact the way those cells function in the body. Therefore, it is important to include antioxidant nutrients in your diet, such as CoQ10. While CoQ10 is rare, statin drugs used to lower cholesterol can adversely affect blood CoQ10 levels. If you think you may be at risk of low CoQ10 levels, talk to your doctor about taking a CoQ10 supplement. To promote heart health or restore normal levels for those on statin drugs, a daily CoQ10 supplement can be useful.

MultivitaminsA daily multivitamin contributes to your nutritional status by filling the vitamin and mineral gaps that may exist in your diet. A daily multivitamin may be sufficient for some people, but for others a multivitamin may lack a needed nutrient or may not provide enough of a nutrient. In such cases, extra supplements may be necessary.

Omega-3 fatty acidsEicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are two omega-3 fatty acids that have been extensively studied for their beneficial role in cardiovascular health. The American Heart Association suggests 500 mg of EPA and DHA per day for healthy adults and 1,000 mg per day for adults with documented heart health concerns.1 Fatty fish like salmon, anchovies, sardines and halibut are some of the strongest sources of EPA and DHA. If you cannot get enough EPA and DHA through the

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foods you eat, then a daily fish oil supplement can be a great source as well. For vegetarians, flaxseed oil provides an omega-3 fatty acid known as alpha-linolenic acid (ALA), which partially converts to EPA and DHA in the body. ALA is also found in walnuts, almonds, avocados and other plant-based foods and oils. Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

Plant sterols and plant stanolsThese compounds have been clinically shown to naturally lower cholesterol levels by preventing the absorption of cholesterol found in your diet.2,3 The National Cholesterol Education Program (NCEP) of the National Institutes of Health recommends 2,000 mg per day of these plant compounds from fortified foods or supplements.

heart





400 IU per day for infants, children and adolescents asrecommended by the American Academy of Pediatrics7

• Higher amounts may be taken under a doctor’s supervision

100-200 mg per day for adults8,9Coenzyme Q10

Omega-3 fatty acidsEPA and DHAorOmega-3 fatty acidALA

500 mg of EPA/DHA per day for healthy individuals1,000 mg of EPA/DHA per day for individuals withdocumented heart conditions*

500-1,500 mg per day of ALA as directed by yourhealthcare provider

Plant sterolsand stanols

The National Cholesterol Education Program of theNational Institutes of Health (NIH) recommends2,000 mg per day of plant sterols and stanols as part ofa heart-healthy diet

Antioxidantvitamins C and E

Vitamin C: 250-1,000 mg per day10

Vitamin E: 200-400 IU per day11

*High levels of EPA/DHA must be monitored closely and taken under a doctor’s supervision.


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Given that plant sterols and stanols compete with dietary cholesterol for absorption in the gut, it is recommended to take a sterol and stanol supplement 15 to 30 minutes before a meal. For the greatest effect, it is advised to take sterol and stanol supplements before meals that contain cholesterol-containing foods like meat, poultry, cheese and eggs.


Coupon good only in USA for product/quantity indicated. LIMIT ONE COUPON PER PURCHASE. Any other use constitutes fraud. Void if copied, transferred, sold, or where prohibited, restricted or taxed. Consumer pays sales tax. Retailer: Pharmavite LLC will reimburse an authorized retailer of our product the face value of this coupon plus 8¢ handling if submitted in compliance with our redemption policy, available upon request. Mail to CMS Dep’t #31604, Pharmavite 1 Fawcett Drive, Del Rio, TX 78840. Cash value .001¢. © 2012 Pharmavite. Expires 5/1/13.

CONSUMER: Limit one coupon per purchase as specified on the face of this coupon. No other coupon may be used in conjunction with this coupon. RETAILER: We will reimburse you the face value of this coupon plus 8¢ handling, provided it is redeemed by a consumer at the time of purchase on the brand specified. Coupons not properly redeemed will be void and held. Reproduction of this coupon is expressly prohibited. (Any other use constitutes fraud.) Invoices proving purchase of sufficient stock within the past 90 days to cover coupons presented for redemption must be shown upon request. Mail to: CMS Dept. 89269, The Coromega Company, 1 Fawcett Drive, Del Rio, TX 78840. Cash value 1/100. Void where taxed or restricted. LIMIT ONE COUPON PER ITEM PURCHASED. For CMS inquires please call 800-285-7602. Expires 5/1/13.


Offer good only at WalgreensOffer good only at Walgreens

Any Nature Made® product

Coromega® Omega 3 Squeeze 30 pack

Any BluScience™

Chromadex products

$2off

$5off$2offThis coupon good only on the purchase of BluScience™ products. Any other use constitutes fraud. Coupon not transferable. Limit one coupon per purchase. Coupon cannot be combined with other coupons or offers. Customer must pay sales tax. RETAILER: ChromaDex, Inc. will reimburse you the face value of this coupon, plus 8¢ if submitted in compliance with the terms of this offer. Valid only if redeemed by distributors of our merchandise or anyone specifically authorized by ChromaDex, Inc. Cash value 1/20¢. Mail to: ChromaDex, Inc., 10005 Muirlands Blvd., Suite G, Irvine, CA 92618-2538. Expires 5/1/13.

$2off

CONSUMER: Void if sold, copied, transferred, altered, or auctioned. Only one coupon is redeemable per purchase and only on specified product(s) and size(s). You pay any sales tax. RETAILER: We will reimburse you for the face value of the coupon plus 8 cents if submitted in compliance with our redemption policy, available upon request. Cash value 1/20 cents. Mail to Meda Consumer Healthcare Inc., PO Box 880414, El Paso, TX 88588-0414. Limit one coupon per purchase. Meda Consumer Healthcare Inc. ©2012. Expires 5/1/2013.


Feosol® Original or Natural Release Iron Supplement


† This statement has not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

John Probst, RPhPharmacist /Manhattan Beach, CA

“It’s never too early to take steps to support your heart health. Nature Made® is a great way to start.”


immune

What supplements can help my immune system function best? The immune system mission is simple: recognize free radicals and eliminate them. When you have a healthy immune system, your body is doing a good job of fighting off invaders and keeping your body’s health strong.

Vitamin C has been shown to have a positive effect on the body’s immune cells. Here are other important nutrients that can support a healthy immune system:1

• Echinacea • Multivitamins • Vitamin C • Vitamin E • Zinc

EchinaceaEchinacea is one of the most popular herbs in the United States, taken by many people when they are not feeling their best. Echinacea is thought to benefit immune health, particularly when unwanted symptoms are present or when you feel at risk of becoming sick.2 Even though echinacea is recognized as a safe herbal supplement when taken as directed, it is still recommended that you check with your doctor about your supplement use. This is especially important if you are taking medications, are pregnant or breastfeeding or have a diagnosed auto-immune condition.

MultivitaminsA daily multivitamin contributes to your nutritional status by filling the vitamin and mineral gaps that may exist in your diet. A daily multivitamin may be sufficient for some people, but for others a multivitamin may lack a needed nutrient or may not provide enough of a nutrient. In such cases, extra supplements may be necessary.

Vitamin CVitamin C has been found to protect the integrity of cells and stimulate the production and function of white blood cells.1 As a powerful antioxidant, vitamin C helps fight against free radicals in the body. Free radicals are compounds that can harm your healthy cells — including your immune fighting cells — and negatively impact the way those cells function in the body. Vitamin C is abundant in many fruits and vegetables and can also be obtained in supplement form.

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Vitamin C 500-1,000 mg per day

Vitamin E 200-400 IU per day

Zinc 8-30 mg per day

Echinacea 350 mg aerial parts, four times per day

Vitamin D 1,000-2,000 IU per day for adults

400 IU per day for infants, children and adolescents as recommended by the American Academy of Pediatrics2



Vitamin EMany studies show that vitamin E plays an important role in the maintenance of a healthy immune system. Vitamin E also protects against free-radical damage. Environmental pollution, the sun’s ultraviolet rays, cigarette smoke and certain health conditions are all capable of triggering free-radical damage in our bodies.

ZincZinc is needed for your body to carry out its normal immune response when invaders attack. Zinc is involved in additional aspects of your health, including growth and development, nervous system function, antioxidant activity and reproduction.

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Consumer: Redeemable at retail locations only. Not valid for online or mail-order purchases. Retailer: Irwin Naturals will reimburse you for the face value plus 8 (cents) handling provided it is redeemed by a consumer at the time of purchase on the brand specified. Coupons not properly redeemed will be void and held. Reproduction by any party by any means is expressly prohibited. Any other use constitutes fraud. Irwin Naturals reserves the right to deny reimbursement (due to misredemption activity) and/or request proof of purchase for coupon(s) submitted. Mail to: CMS Dept. 10363, Irwin Naturals, 1Fawcett Drive, Del Rio, TX 78840. Cash value: .001 (cents). Void where taxed or restricted. ONE COUPON PER PURCHASE. Not valid for mail order/websites. Retail only. Expires 5/1/13.

RETAILER: We will reimburse you the face value of this coupon plus 8¢ handling, provided it is redeemed by a consumer at the time of purchase on the brand specified. Coupons not properly redeemed will be void and held. Reproduction of this coupon is expressly prohibited (ANY OTHER USE CONSTITUTES FRAUD.) MAIL TO: Alacer Corp., CMS Dept #76314, One Fawcett Drive, Del Rio, TX 78840. Cash Value .001¢. Void where prohibited, taxed or restricted by law. LIMIT ONE COUPON PER ITEM PURCHASED. © 2012 Alacer Corp. All Rights Reserved. Expires 5/1/13.

Retailer: Northwest Natural Products will reimburse you the face value of this coupon plus 8 cents handling for coupons redeemed in accordance with this offer. Invoices proving purchase of sufficient stock to support coupon submissions must be provided upon request. Consumers are limited to one coupon per purchase and are responsible for all taxes. Cash value is .0001 cents. Send all coupons to: NUNO/Universal, P.O. Box 222510, Hollywood, FL 33022-2510. Expires 5/1/13.

RETAILERS: We will reimburse you the face value of this coupon plus 8¢ handling provided you and the consumer have complied with the terms of this offer. Invoices proving purchases of sufficient stock to cover presented coupons must be shown on request. Any other application may constitute fraud. Coupon void where prohibited, taxed, or restricted. Consumer must pay any sales tax. Cash value .001¢. Reproduction of this coupon is expressly prohibited. Mail to: Upsher-Smith Laboratories, Inc. #00245, One Fawcett Drive, Del Rio, TX 78840. This coupon is immediately redeemable for $4.00 off the retail price of Slo-Niacin® Tablets (500 mg). Only one coupon per each purchase made by 5/1/13. Applies only in U.S.A. Void where prohibited by law. Upsher-Smith Laboratories, Inc., reserves the right to rescind, revoke, or amend this offer without notice. Expires 5/1/13.





Any 30 ct. box of Emergen-C® vitamin drink mixes

vitafusion® B Complex Gummy Vitamins 150 ct.

Applied Nutrition® Supplements

SLO-NIACIN® Dietary Supplement 100 ct. Tablets, 500 mg.

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prenatal health

What steps should I take to help ensure a healthy pregnancy? If you are pregnant or are hoping to conceive, it is important to receive the best prenatal care by seeing your OB/GYN regularly and taking steps to ensure the health of you and your baby.

A healthful, balanced diet that includes plenty of whole fruits and vegetables, whole grain products, lean protein and healthy fats will help ensure good health for you and your baby throughout pregnancy. The dietary choices you make during this time will have a powerful effect on giving your baby a strong start in life.

Read on to learn more about how vitamins and minerals help support your health during pregnancy:

• Prenatal multivitamins • Calcium • Folic acid • Iron • Omega-3 fatty acids • Supplemental algae • Vitamin C • Vitamin D • White fatty fish

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Prenatal multivitaminsThese nutrients are critical during pregnancy, and support your needs and those of your growing baby. Pregnancy places a higher demand on the body, and increases the amount of nutrients required. Adequate amounts of essential vitamins and minerals and other key nutrients during pregnancy are vital to the development of your baby, and for your health too!

CalciumCalcium’s primary responsibility during pregnancy is to maintain strong maternal bone health and promote healthy fetal bone development. Calcium also helps your circulatory, muscular and nervous systems to run normally.1

Folic acidFolic acid plays a critical role in the formation and development of a baby’s brain and spine — an important process that occurs during the initial three to four weeks of pregnancy. If you have a diagnosed malabsorption concern or any condition that may limit your dietary intake of folic acid, you may benefit from a folic acid supplement. Be sure to talk to your doctor about safe supplement use.

prenatal

To help avoid some common side effects from a prenatal multivitamin such as queasiness or stomach upset, take your prenatal supplement with a substantial meal or snack. Some women may benefit from chewing gum or sucking on a hard candy after taking their prenatal, while others may have better luck with taking it at night with an evening snack.

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IronDuring pregnancy, a woman’s iron needs increase. In fact, they are nearly twice those of a nonpregnant woman. To ensure adequate iron status, it is important to consume iron-rich foods such as lean meat, poultry, dried fruits and iron-fortified cereals. Prenatal formulas and iron supplements can also help fulfill the high demand for iron during pregnancy and the post partum period.

Omega-3 fatty acidsThe omega-3 fatty acid docosahexaenoic acid (DHA) is especially important because it promotes the healthy growth and development of your baby’s brain, eyes and nervous system.2 Mothers of breast-fed infants should be aware that breast milk is not naturally high in DHA. If you choose to breastfeed your child, ensure you have adequate DHA in your diet or through supplementation.

Supplemental algaeSupplemental algae oil is a fish-free way to get DHA. Also, alpha linolenic acid (ALA) found in flaxseed oil, canola oil and walnuts is an omega-3 fatty acid that is partially converted to DHA in the body.

Vitamin CVitamin C promotes the absorption of non heme iron, a form of iron found in plants and fortified foods. Taking a vitamin C supplement with your iron supplement or eating citrus fruits with your iron-fortified cereals can promote optimal absorption of non heme iron. This is particularly applicable for women who are vegetarian, or vegan.


prenatal

Vitamin DFor pregnant women, maintaining sufficient vitamin D status is critical for proper fetal development, especially brain and immune system development. Vitamin D also is important for keeping your bones and your baby’s bones healthy and strong. Furthermore, research suggests adequate maternal intake of vitamin D during pregnancy has been associated with a decreased risk of childhood wheezing and eczema.4,5 To find out your current vitamin D levels, talk to your healthcare provider about the 25-hydroxy vitamin D test. Most prenatal vitamins don’t contain optimal amounts of vitamin D. In addition to your prenatal vitamin, drink vitamin D-fortified low-fat milk and other calcium-rich foods containing vitamin D. If you don’t drink or eat calcium-rich foods, talk to you healthcare provider about calcium and vitamin D supplements.

White fatty fishWhile fatty fish are the best dietary sources of omega-3 fatty acids, women of child-bearing age and pregnant women are advised to avoid certain fish that may have a high content of methylmercury, a compound that can affect the development of the baby’s nervous system.3 Fish to avoid include shark, swordfish, king mackerel and tilefish. Cooked fish, such as salmon, have a stronger safety profile for pregnant women; in general, up to 12 ounces per week of cooked fish may be consumed. Fish oil supplements are also available to help meet the recommendations for DHA. Your primary healthcare provider can help you choose a safe omega-3 supplement during pregnancy and lactation.

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Nutrient Suggested use for prenatal health

Prenatal multivitamins 1 per day or as directed by your healthcare provider

Folic acid 600 mcg per day during pregnancy500 mcg per day during lactation

Omega-3 fatty acids(DHA)

DHA: at least 200 mg per day or as directed by yourhealthcare provider. Some experts recommend300-600 mg per day

Iron 27 mg per day or as directed by your healthcare provider

Calcium 1,000 mg per day in two divided doses

Vitamin D 1,000-2,000 IU per day or as directed by your healthcare provider

Nutrient Suggested use for children’s health

Children’s multivitamins 1 per day or take as directed by pediatrician

Iron Children1 to 3 years: 7 mg per day /4 to 8 years: 10 mg per dayAdolescent male9 to 13 years: 8 mg per day / 1 4 to 1 8 years: 11 mg per dayAdolescent female9 to 13 years: 8 mg per day / 1 4 to 1 8 years: 15 mg per day

Calcium Children1 to 3 years: 500 mg per day /4 to 8 years: 800 mg per dayAdolescent male9 to 13 years: 1,300 mg per day / 1 4 to 1 8 years: 1,300 mg per dayAdolescent female9 to 13 years: 1,300 mg per day / 1 4 to 1 8 years: 1,300 mg per day

Fluoride As directed by a pediatrician or dentist

Choline Children1 to 3 years: 200 mg per day /4 to 8 years: 250 mg per day9 to 13 years: 375 mg per dayAdolescent male1 4 to 1 8 years: 550 mg per dayAdolescent female1 4 to 1 8 years: 400 mg per day



These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

WARNING: Accidental overdosage of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

4095-0212A1701a_Feosol-Walgreens-Insert_022312_r11_OL.indd 1 2/27/2012 10:07:31 AM


Consumer: Limited one coupon per customer per offer. Expires 5/1/2013. Manufacturer coupon good only at Walgreens. Consumer pays any sales tax. Retailer: International Vitamin Corporation will reimburse you for face value of this coupon plus 8 ¢ handling. Coupons not properly redeemed will be void and held. Reproduction of this coupon is expressly prohibited. Cash value 1/100 of 1 cent. Mail to: Sponge Bob Gummi $1 Coupon, PO Box 5098, Clinton, IA 52736-5098. SpongeBob SquarePants ©2011 Viacom International Inc. All Rights Reserved. Nickelodeon, SpongeBob SquarePants and all related titles, logos and characters are trademarks of Viacom International Inc. SpongeBob SquarePants created by Stephen Hillenburg. www.nick.com. Expires 5/1/2013.

LIMIT 1 COUPON PER PRODUCT SPECIFIED. Cannot be combined with other offers. Void if altered, reproduced, copied, sold, transferred, taxed, restricted or prohibited by law. Good only in USA and territories. Cash value 1/100¢. Customer pays sales tax. Retailer/Clearinghouse: By submitting, you agree to Abbott’s Coupon Redemption Policy. Abbott will reimburse you face value of coupon (or actual retail price of item if less) plus 8¢ handling. Send to CMS Dept 70074, ABBOTT NUTRITION, 1 Fawcett Dr., Del Rio, TX 78840. Pharmacists/Retailers: Coupon not valid for product reimbursed, in whole or part, under Medicare, Medicaid or similar federal or state government programs. Expires 5/1/13.

Offer good only at WalgreensOffer good only at Walgreens


Any Flintstones™ Complete Multivitamins & Gummies products

SpongeBob® SquarePants Gummies Multivitamin 240 ct.

Similac® Prenatal Vitamins Dietary Supplement product

$1off

$1off

$1off

CONSUMER: Void if sold, copied, transferred, altered, or auctioned. Only one coupon is redeemable per purchase and only on specified product(s) and size(s). You pay any sales tax. RETAILER: We will reimburse you for the face value of the coupon plus 8 cents if submitted in compliance with our redemption policy, available upon request. Cash value 1/20 cents. Mail to Meda Consumer Healthcare Inc., PO Box 880414, El Paso, TX 88588-0414. Limit one coupon per purchase. Meda Consumer Healthcare Inc. ©2012. Expires 5/1/2013.


Feosol® Complete Iron Supplement

$4off


children’s health

How do vitamins support my child’s health? As your child grows, vitamins and minerals play a big part in building and maintaining health. They help with many important things, including bone and brain development, energy production and muscle function as well as preventing tooth decay. However, knowing which vitamins you should give your child can be a challenge. So, if you are unsure about your child’s nutritional and vitamin needs, talk with your pediatrician. Remember to keep vitamins out of the reach of children.

The vitamins and minerals discussed in this section include

• Children’s multivitamins • Calcium • Choline • Fluoride • Iron • Vitamin D

Vegetarians may have inadequate levels of this vital nutrient. If your child may be at risk of low dietary choline, you might want to consider supplementation. Some children’s multivitamin formulas provide choline, so you can support your child’s diet and ensure adequate levels of this brain-boosting nutrient.

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children’s

Children’s multivitaminsMuch like a formula for adults, a daily children’s multivitamin can help fill the gaps that may exist in a child’s diet. Purchase, prepare and provide healthful foods, and show your child that you eat and enjoy them, too. Encourage fruits, vegetables, dairy, whole grains and lean meats when you talk about “everyday” foods, and sweets and sugars when you discuss foods in moderation. The key nutrients below are important elements of your child’s diet. If meeting your child’s nutritional needs is hard to do through foods alone, a children’s multivitamin may help.

CalciumCalcium is another important component of a child’s diet, and is necessary for building and maintaining healthy bones and teeth. Children who drink milk and eat dairy products, such as yogurt, ice cream and cheese, usually get enough calcium from their diet. However, some kids just don’t like milk or can’t tolerate milk due to a milk allergy. In these cases, providing a children’s multivitamin, calcium-fortified foods and juices or increasing your child’s intake of dark leafy greens can help meet their needs appropriately.

CholineCholine plays an important role during the early years of child development. It is used in the synthesis of key components necessary for healthy cell membranes called phospholipids. Choline is also involved in the formation of neurotransmitters, which are important for proper brain and muscle function.7 Choline is found in foods, such as milk, eggs, liver, shrimp


children’s

and peanuts. Children who do not consume milk or eggs, who have a peanut or shellfish allergy, or who are vegetarian, may have inadequate levels of this vital nutrient.

FluorideMost children get enough fluoride to build healthy teeth and prevent tooth decay if they are drinking fluoridated water. Supplemental fluoride is not necessary for all children, especially since too much fluoride can cause staining of the teeth. Consult your child’s pediatrician or dentist before giving your child a fluoride supplement.

IronIron is an essential nutrient involved in numerous bodily functions, including normal growth and development, energy production and the transportation of oxygen to the body’s tissues. Those most at risk for iron deficiency anemia are infants who are not given extra iron after six months of age (usually in the form of iron-fortified infant cereal) and adolescent girls once they begin menstruation.

Vitamin DIn 2008, the American Academy of Pediatrics increased the recommended intake of vitamin D for all infants, children and adolescents to 400 I.U. per day. In its report, the AAP discussed the rising rate of vitamin D deficiency among infants, children and adolescents, and the potential risks of low vitamin D status, including Rickets (softening of the bones), and negative effects on heart and immune health.6

Nutrient Suggested use for prenatal health

Prenatal multivitamins 1 per day or as directed by your healthcare provider

Folic acid 600 mcg per day during pregnancy500 mcg per day during lactation

Omega-3 fatty acids(DHA)

DHA: at least 200 mg per day or as directed by yourhealthcare provider. Some experts recommend300-600 mg per day

Iron 27 mg per day or as directed by your healthcare provider

Calcium 1,000 mg per day in two divided doses

Vitamin D 1,000-2,000 IU per day or as directed by your healthcare provider

Nutrient Suggested use for children’s health

Children’s multivitamins 1 per day or take as directed by pediatrician

Iron Children1 to 3 years: 7 mg per day /4 to 8 years: 10 mg per dayAdolescent male9 to 13 years: 8 mg per day / 1 4 to 1 8 years: 11 mg per dayAdolescent female9 to 13 years: 8 mg per day / 1 4 to 1 8 years: 15 mg per day

Calcium Children1 to 3 years: 500 mg per day /4 to 8 years: 800 mg per dayAdolescent male9 to 13 years: 1,300 mg per day / 1 4 to 1 8 years: 1,300 mg per dayAdolescent female9 to 13 years: 1,300 mg per day / 1 4 to 1 8 years: 1,300 mg per day

Fluoride As directed by a pediatrician or dentist

Choline Children1 to 3 years: 200 mg per day /4 to 8 years: 250 mg per day9 to 13 years: 375 mg per dayAdolescent male1 4 to 1 8 years: 550 mg per dayAdolescent female1 4 to 1 8 years: 400 mg per day


child

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52 53


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flintstonesvitamins.com

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menopause

How can supplements help ease symptoms of menopause?In menopause, a woman’s period stops permanently. This happens when the ovaries stop making estrogen and progesterone. The natural transition to menopause can take many years. But symptoms can appear as soon as the change begins. Common symptoms include hot flashes, night sweats, trouble sleeping and vaginal dryness. Other symptoms include memory problems, physical complaints and mood changes. The changes of menopause also increase the risk for osteoporosis, heart disease and stroke.

Although research as not yet seen conclusive results, some women use vitamins, minerals and supplements to help manage their symptoms. Studies of certain supplements for menopause have had varying results. If you want to take dietary supplements for menopause, talk with your doctor first. Together you can discuss the possible benefits and side effects of supplements and decide which ones might be right for you.

Several vitamins, minerals and supplements might be helpful for women during menopause. These include

• B Vitamins: B6, B12 and folic acid • Calcium and vitamin D • Soy • Vitamin E

menopause

56 57men

opau

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B vitamins: B6, B12 and folic acidHormonal changes in menopause may increase the body’s levels of an amino acid called homocysteine. This can increase the risk for heart disease and stroke. Folic acid and vitamins B6 and B12 may help lower homocysteine levels.2,3

Calcium and vitamin DCalcium and vitamin D are important for bone health. This is especially important in menopause, when the risk for osteoporosis rises. Most women should have 1,200 mg of calcium a day from food and supplements. Most women should also have 800 IU to 1,000 IU of vitamin D per day. Diet and sunlight provide some vitamin D. However, a supplement may be needed in menopause. Ask your doctor how much calcium and vitamin D you should take, especially if you have a history of kidney stones.1


SoySoy contains estrogen-like compounds called isoflavones. Soy proteins might also lower the risk for osteoporosis and heart disease. Some women should be cautious when taking soy, including those with a history of estrogen-receptive cancer or those taking medications that increase estrogen levels.4,5,10

Vitamin EVitamin E is an antioxidant. It is thought to relieve inflammation and support immune systems. It is found in many foods. It is also available as a supplement.7,8

Supplement Suggested use

B Vitamins:B6 and B12

Vitamin B6: Age 19 to 50, 1.3 mg per day Age 51+, 1.5 mg per day a,10

Vitamin B12: 2.4 mcg a,11

Folic acid Because folic acid (folate) from natural foods is absorbed by the body differently than folic acid in supplements, talk to your doctor about the best amount for you.

Calcium and vitamin D

Calcium: 1,200 mg per day from food and supplements1

Vitamin D: 800 IU per day to 1,000 IU per day to prevent osteoporosis1

Soy 25 grams per day of soy protein to reduce the risk of heart disease 7

Vitamin E 22.4 IU a,9

100-200 mg. per day for adultsa,9

a These are the recommended dietary allowances for general health. Ask your doctor if you need a different amount during menopause.

men

opau

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References:Beauty1 Greul AK, Grundmann JU, Heinrich F, Pfitzner I, Bernhardt J, Ambach A,

Biesalski HK, Gollnick H. (2002). Photoprotection of UV irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol Appl Skin Physiol.,15, 307-15.

2 Zhao JF, Zhang YJ, Jin XH, Athar M, Santella RM, Bickers DR, & Wang ZY. (1999). Green Tea Protects Against Psoralen Plus Ultraviolet A-Induced Photochemical Damage to Skin. J Invest Dermatology¸113, 1070-1075.

3 Elmets CA, Singh, D, Tubesing K, Matsui M, Katiyar S, Muktar H. (2001). Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J Amer Acad Dermatol., 44, 425-432.

4 Placzek M, Gaube S, Kerkmann U, Gilbertz K, Herzinger T, Haen E, & Przybilla B. (2005). Ultraviolet B-Induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and d-alpha Tocopherol. Journal of Invest Dermatology, 124, 304-307.

5 Cosgrove MC, Franco OH, Granger SP, Murray PG, & Mayes AE. (2007). Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Amer J Clin Nutrition, 86, 1225-1231.

6 Matsuoka LY, Ide L, Worstman J, MacLaughlin JA, & Holick MF. (1987). Sunscreens Suppress Cutaneous Vitamin D3 Synthesis. Jour of Clinical Endocrinology and Metabolism, 64, 1165-1168.

7 Jones W, Li X, Qu ZC, Perriot L, Whitesell RR, & May JM. (2002). Uptake, recycling and antioxidant actions of alpha-lipoic acid in endothelial cells. Free Radical Biology Medicine, 33, 83-93.

8 May JM, Qu ZC, & Mendiratta S. (1998). Protection and recycling of alpha-tocopherol in human erythrocytes by intracellular ascorbic acid. Arch Biochemical Biophys, 349, 281-289.

9 “The Water Soluble Vitamins: B Vitamins and Vitamin C” in Whitey E, & Rolfes SR. (Eds.), Understanding Nutrition (322-368), Belmont: Thomas Wadsworth.

Bone & joints1 Song Y, et al. Dietary magnesium intake and risk of cardiovascular disease among

women. Am J Cardiol 2005;96:1135-1141.2 Dickinson HO, et al. Lifestyle interventions to reduce raised blood pressure: a

systematic review of randomized controlled trials. J Hypertens 2006;24:215-233.3 Rodriguez-Moran M, Guerrero-Romero F. Oral magnesium

supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 2003;26:1147-1152.

4 Rozendaal RM, et al. Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial. Osteoarthritis Cartilage 2009;17:427-32. Epub 2008 Oct 9.

5 Herrero-Beaumont G, Ivorra JA et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator Arthritis Rheum 2007;56:555-567.

6 Svetlova MS, Ignat’ev VK. Experience with glucosamine hydrochloride in the treatment of patients with osteoarthritis [Russian]. Ter Arkh 2005;77:64-67.

7 Schmid B, et al. Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother Res 2001;15:344-350.

8 Chrubasik S, Einsenburg E, et al. Treatment of low back pain exacerbation with willow bark extract: a randomized double-blind study. Am J Med 2000;109:9-14.

9 Chrubasik S, Kunzel O, et al. Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study. Phytomedicine 2001;8:241-251.

10 Kalman DS, et al. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint®) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J 2008;7:3-12

Cognitive1 Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. (2005) Fish

consumption and cognitive decline with age in a large community study.Archives of Neurology, 62(12).

2 Buell JS, Scott TM, Dawson-Hughes B. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):888-95.

3 Jyme H. Schafer, MD, MPH; Thomas A. Glass, PhD. Homocysteine and Cognitive Function in a Population-based Study of Older Adults. J Am Geriatr Soc. 2005;53(3):381-388.

4 Cipolli C, & Chiari G. (1990) Effects of L-acetylcarnitine on mental deterioration in the aged: initial results. Clin Teri, 132, 479-510.

Digestive health1 Douglas LC, & Sanders ME. (2008). Probiotics and Prebiotics in Dietetics Practice.

J Am Diet Assoc, 108, 510-521.2 Collins MD, & Gibson GR. (1999). Probiotics, prebiotics and synbiotics: approaches for

modulating the microbial ecology of the gut. Amer J of Clin Nutr, 69, 1052s-1057s.3 Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, & Holick MF. (2006).

The Role of Vitamin D in Cancer Prevention. Amer Journal of Public Health, 96, 252-261.4 Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, & Heaney RP. (2007). Vitamin

D and calcium supplementation reduces cancer risk: result of a randomized trial. Amer Journal of Clin Nutr, 85, 1586-1591.

Heart health1 Harris WS, Kris-Etherton PM, Harris KA. Intakes of long-chain omega-3 fatty acid

associated with reduced risk for death from coronary heart disease in healthy adults. Curr Atheroscler Rep. 2008;10(6):503-509

2 Berger A, Jones PJ, Abumweis SS. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis. 2004;3(1):5.

3 Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R. Efficacy and safety ofplant stanols and sterols in the in management of blood cholesterol levels. Mayo Clin Proc. 2003;78(8):965-978.

Immune health1 Jariwalla RJ, Harakeh S. Antiviral and immunomodulatory activities of ascorbic acid.

In: Harris JR (ed). Subcellular Biochemistry. Vol. 25. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. New York: Plenum Press; 1996:215-231.

2 Linde K, Barrett B, Bauer R, Melchart D, Woelkart K. Echinacea for preventing and treating the common cold. Cochrane Database of Systematic Reviews 2006, Issue 1.

Menopause1 Managing menopause at home. MedlinePlus. http://www.nlm.nih.gov/medlineplus/ency/

patientinstructions/000392.htm. Accessed January 17, 2012.2 The healthy heart handbook for women. National Heart, Lung, and Blood Institute.

www.nhlbi.nih.gov/health/public/heart/other/hhw/hdbk_wmn.pdf. Accessed January 17, 2012.

3 Stroke risk reduction: A healthy nutrition guide. National Stroke Association. http://www.stroke.org/site/DocServer/NSAFactSheet_Eating.pdf?docID=987. Accessed January 19, 2012.

4 Herbs at a glance. National Institutes of Health. nccam.nih.gov/health/NIH_Herbs_at_a_Glance.pdf. Accessed January 17, 2012.

5 Menopausal symptoms and CAM. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/menopause/menopausesymptoms.htm. Accessed January 17, 2012.

6 Soy. MedlinePlus. http://www.nlm.nih.gov/medlineplus/ency/article/007204.htm. Accessed January 19, 2012.

7 Pros and cons for treatment of menopause symptoms. The Hormone Foundation. http://www.hormone.org/Menopause/pros_and_cons.cfm. Accessed January 19, 2012.

8 Dietary supplement fact sheet: vitamin E. Office of Dietary Supplements. http://ods.od.nih.gov/factsheets/vitamine. Accessed January 19, 2012.

Prenatal and children’s1 Gropper, S. S., Smith, J. L., & Groff, J. L. (2009). Advanced Nutrition and Human

Metabolism. Belmont, CA: Wasdwoth.2 Cetin I, Koletzko B. Long-chain omega-3 fatty acid supply in pregnancy and lactation.

Curr Opin Clin Nutr Metab Care 2008;11:297-302.3 U.S. Food and Drug Administration and Center for Food Safety and Applied Nutrition.4 Miyake Y. et al. Dairy food, calcium, and vitamin D intake in pregnancy and wheeze

and asthma in infants. Eur Respir J. 2009 Oct 19. [Epub ahead of print]5 Devereux G. et al. Maternal vitamin D intake during pregnancy and childhood wheezing.

Am J Clin Nutr. 2007 Mar;85(3):853-9.6 Wagner CL & Greer FR. (2008) Prevention of Rickets and Vitamin D Deficiency in Infants,

Children, and Adolescents. Pediatrics, 122, 1142-1152.7 Blusztajn, JK, et al. Synthesis of acetylcholine from choline derived from

phosphotidylcholine in a human neuronal cell line. Proc Natl Acad Sci USA 1987;84:5474-7.

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