Impulse Control Disorders & their genetics are we talking about? Impulse control disorders & Impulse related behaviours Pathological gambling Hypersexuality Compulsive eating Compulsive

Impulse Control Disorders & their genetics

31st January 2018

Department of Clinical Neuroscience,Institute of Neurology

Dr Richard Rees

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Derek

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What are we talking about?Impulse control disorders & Impulse related behaviours

Pathological gambling

Hypersexuality

Compulsive eating

Compulsive shopping

Punding

Hobbyism

Walkabout

Dopamine dysregulation syndrome

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Who’s at risk?

On Parkinson's Treatment

Younger age

Male

Smoker

SingleAnxiety

High novelty seeking

FHx of addictive disorders

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Where does Tracking Parkinson’s fit?

Clinical data

Longitudinal

QUIP

Drug data

Demographic data

Genetics

Candidate Gene Study

Genome Wide Association

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Prevalence in PRoBaNDLax• ICD only

– 27%• IRB only

– 29%• Any behaviour

– 42%

Strict• ICD only

– 11%• IRB only

– 27%• Any behaviour

– 31%

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GWAS

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GWAS

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Why does this matter?• What can I do next?

– Be aware of ICD in PD– Ask about key behaviours– Highlight to study groups

• Future work– Using rich longitudinal data– Replication in other cohorts (IPDGC/UK)– Personalised medicine

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