Immunology The study of the organs, tissues and cells that create the body’s fight against disease. Immunity – ability to stop a pathogen from establishing an infection, sometime before symptoms even occur. Susceptibility – condition where a pathogen is able to successfully reproduce / replicate in a host.
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Immunology The study of the organs, tissues and cells that create the body’s fight against disease. Immunity – ability to stop a pathogen from establishing.
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ImmunologyThe study of the organs, tissues and
cells that create the body’s fight against disease.
Immunity – ability to stop a pathogen from establishing an infection, sometime before symptoms even occur.
Susceptibility – condition where a pathogen is able to successfully reproduce / replicate in a host.
The Immune System
– The Immune System is made up of:
– the cells in our bone marrow, thymus, – the spleen, the tonsils, the adenoids, skin, – the lymphatic system of vessels, ducts &
nodes,– blood and its contents
Look for these terms in the video:• Physical Barriers
Interleukin• Muscle Pain
Dendritic Cells• Fever
T-Cells• Cough
B-Cells• Natural Killer Cells
Antibodies• Macrophage
Memory Cells
The Immune System
Innate Immune System Acquired Adaptive Immune System(Learned Specific Immune System)
Response is non-specific Pathogen and antigen specific response
Exposure leads to immediate maximal response
Lag time between exposure and maximal response
Cell-mediated and humoral components
Cell-mediated and humoral components
No immunological memory Exposure leads to immunological memory
Found in nearly all forms of life Found only in jawed vertebrates
Physical Barriers
Natural Killer Cells
Macrophages
– “Big Eaters”, mature from Monocytes
– Patrol the interstitial areas for invaders
– Phagocytes, clean-up host debris
– Consume pathogens directly
– Non-specific – look for anything non-host
– Release interleukin
Specific Immunity
• Boost non-specific responses
• Identify specific invaders by their antigen
• Respond with a specific defense against the invading pathogen
• Memory of pathogens – “Adaptive”
• Use of a variety of Lymphocytes:– Humoral – B-Cells, antibodies in the blood– Cell-mediated immunity – T-Cells
•Humoral Response(of the “Humors”)
• B Cells – mature in the bone marrow
• Migrate to the lymphatic system
• Activated by antigen
• Release antibodies into the blood while remaining in the lymph system
• Antibodies cover and coat pathogens, rendering them useless and targeted for destruction.
Important Vocabulary
• Antigens - Anything causing an immune response, usually foreign material but may be our own tissues. (Antibody Generators)
• Antibody – molecules produced by the immune cells to identify the antigens of the invading pathogens