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www.cellsignal.com/checkpointsFor pathway key and background please visit:
Immune Checkpoint Signaling in the Tumor Microenvironment
Gal
ectin
-9
B7-
1/B
7-2
B7-
H3
B7-
H4
PD
-L1/
PD
-L2
B7-
H3
?
4-1B
BL
B7-
1/B
7-2
GIT
RL
ICO
SL
OX
40L
CD
40
MH
C
TIM
-3
VIS
TA? ?? LA
G-3
CTL
A-4
PD
-1
OX
40(C
D14
3)
4-1B
BC
D28
GIT
R
ICO
S
CD
40L
TCR
VIS
TA ?
Tumor-specific
CD4+T cellB cellDC
Dendritic Cell
Tumor-promoting Macrophage
M2Macrophage
M1Macrophage
Mast cell
Tumor-specificT cell
Cytotoxicgranules
IFNγ-R
IFNγ
TGF-β
IFNγ
MMPsTGF-β
IL-1βTNF-α
IL-1βTNF-α
IL-6R
ALKROS1EGFRHER2etc.
IL-4
IL-13
IL-6
Oncogenicsignaling
IL-10
MMPs
CCL22
TNF-R
CTL
TReg
FoxP3+
CD4+
IL-10TGF-β
IL-35
IL-10TGF-β
IL-1βTNF-α
TNF-αIL-2
Cytotoxic granules
Arginase
T-bet
MMPsVEGF
IL-10IDO
CCL22
T-betTh1
MSC
T cellpriming
NaiveT cell
Angiogenesis
MMPsVEGF
Tumor-draining Lymph Node
NKT-bet
Th2
Proliferation and production of anti-tumor antibodies
IL-2, 4, 5
Activation/Response Change
Inflammation
Class I antigen presentation;IDO; PD-L1 and other co-inhibitory receptors
Genes of cell growth and survival;PD-L1 and other co-inhibitory receptors
Nucleus
Tumor Cell
NF-κB
Stat1
Stat3
Stat3
Akt
Jak
MAPK
RTKJak
T cell apoptosis
Arginase
Arginase
Co-inhibitory receptor-ligand complex
Co-stimulatory receptor-ligand complex
www.cellsignal.com/cellbiologyFor Research Use Only. Not For Use In Diagnostic Procedures.
17-I
MM
-259
-FLY
1-E1
www.cellsignal.com/cellbiologyFor pathway key and background please visit:
APPLICATIONS & REACTIVITY KEY: WB Western Blotting / IP Immunoprecipitation / IHC Immunohistochemistry / IF Immunofluorescence / F Flow Cytometry / ChIP Chromatin Immunoprecipitation / -IC Immunocytochemistry / -P Paraffin / -F Frozen / E-P Peptide ELISA / H human / M mouse / R rat / Hm hamster / Mk monkey / C chicken / Mi mink / Dm D. melanogaster / X Xenopus / Z zebra fish / B bovine / Dg dog / Pg pig / Sc S. cerevisiae / All all species expected / ( ) 100% sequence homology
For pathway key and background please visit:
For Research Use Only. Not For Use In Diagnostic Procedures.