Jan 20, 2016
IEG - Arc/Arg 3.1
Allatostatin receptor (AlstR)
+ 10 nM Alst
GFP controlled by Arc/Arg 3.1 gene promoterGenetical strategy for silencing a memory-encoding hippocampal cell assembly
Erasing and re-installing a hippocampus-dependent memory
Behavioural protocols and `high-cost decision point´
14-tetrode microdrive 64 channel Neuralynx Cheetah system
Extrafield firing at the high-cost decision point
Nonlocal representations at the choice point preferentially sweepforward of the animal
Nonlocal representations at the choice point sweep down the twochoices separately
Extrafield firing during error correction
Nonlocal representations are correlated but not defined by the orientation of motion
Nonlocal representations occur at locations of highly variable orientation of motion
Difference between histograms of reconstruction error distance during samples with variable orientation of motion and during the rest of the session.
High theta power at the choice points, no SW ripples.
The total amount of nonlocal reconstructedprobability decreased
multiple-T task
In contrast, on the cued-choice task, theforward component of the sweep maintained nonlocality.
Development of nonlocal representations with experienceSplitter cells – unindentified extrafield firing of place cells
hippocampus
ventral striatum
orbitofrontal cortex
(only the prediction component)
(reward anticipation)
(the value of potential choices)
prefrontal cortex
(decision making parameters)
“vicarious trial and error” (VTE) behaviors
behavioral “microchoices”
VTE
Hippocampal reevaluation in spatial navigation
Thank you for your attention