icsh.org€¦ · Web view1 Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology Standardization and Grading Image S1: acanthocytes Abetalipoproteinaemia

1Supplementary images: ICSH Recommendations for Peripheral Blood Cell MorphologyStandardization and Grading

Image S1: acanthocytes

Abetalipoproteinaemia - typical hyperchromic cells with projections of variable length, thickness and shape

J. Burthem, M. Brereton

Image S2: bite cells

Three bite cells


Image S3: blister cells

G6PD deficiency (drug induced haemolysis) - frequent blister cells with associated damaged cells


Image S4: echinocytes

Renal failure – cells with evenly spaced, short, blunt projections



Image S5: ovalocytes and elliptocytes

Hereditary elliptocytosis


Image S6: irregularly contracted cells

Unstable haemoglobin


Image S7: schistocytes

Thrombotic thrombocytopenic purpura – a wide range of fragmented red cells with polychromatic cells and other damaged cells. Platelets are absent from the film


Image S8: sickle cells

Sickle cell disease – typical forms together with other features, notably polychromasia, target cells, and a spherocytic cell.



Image S9: spherocytes

Autoimmune haemolytic anaemia – typical round, dense red cells


Image S10: stomatocytes

Hereditary stomatocytosis


Image S11: target cells

Haemoglobin C disease – target cells in association with irregularly contracted cells


Image S12: tear drop cells

Myelofibrosis



Image S13: basophilic stippling

Myelofibrosis - two stippled cells, one in teardrop form


Image S14: Howell-Jolly bodies

Auto-splenectomised patient with sickle cell disease


Image S15: Pappenheimer bodies

Sideroblastic anaemia – red cells contain small basophilic inclusions of variable size and shape in a limited cytoplasmic area

G. Rozenberg

(**copyright – see statement at end)

Image S16: nucleated red blood cell

Myelofibrosis – a typical late stage nucleated red cell in circulation



Image S17: large granular lymphocyte

Large granular lymphocyte from a normal individual


Image S18: Auer rods

AML – two blast cells containing relatively blunt-ended, single and multiple Auer rods


Image S19: hypergranulation(neutrophils)

Hypergranular neutrophils post G-CSF treatment


Image S20: hypogranulation(neutrophils)

Myelodysplasia – hypogranular neutrophils.Note also the atypical nuclear forms

G. Rozenberg



Image S21: Pelger Huet neutrophils

Pelger Huet anomaly – classic bi-lobed cells with dense chromatin condensation but normal granulation


Image S22: leukaemic myeloblasts

Acute myeloid leukaemia (AML) – hypogranular primitive blast cells


Image S23: abnormal promyelocytes in APL (1)

APML – two hypergranular promyelocytes


Image S24: abnormal promyelocytes in APL (2)

Abnormal promyelocyte containing multiple Auer rods (faggot cell)

G. Rozenberg



Image S25: monoblasts

Acute monoblastic leukaemia – monoblasts and promonocytes


Image S26: abnormal promonocytes

Chronic myelomonocytic leukaemia (CMML)

G. Zini

Image S27: reactive lymphocytes

Infectious mononucleosis – typical reactive lymphocytes with flowing basophilic cytoplasm


Image S28: hairy cells

Hairy cell leukaemia



Image S29: follicular lymphoma cells

Circulating follicular lymphoma cells – note the small cells with cleaved nuclei and sparse cytoplasm


Image S30: plasma cells

Plasma cell leukaemia. Note also the background protein staining and the associated red cell rouleaux. Note that one plasma cell has features of immaturity and may be regarded as a plasmablast.


Image S31: prolymphocytic leukaemia cells

B-Prolymphocytic leukaemia


Image S32: chronic lymphocytic leukaemia cells

Typical CLL lymphocytes with a smudge cell



Image S33: giant platelets

Myelofibrosis – some large and giant abnormally granulated platelets and a micromegakaryocyte


Image S34: hypogranular platelets

Myelofibrosis – variable platelet appearance with normal and abnormally granulated platelets together with some large hypogranular forms


Image S35: micromegakaryocytes

Myelofibrosis – note the typical ‘granulated’ platelet cytoplasm. A bare megakaryocyte nucleus is also present


** These images copyright: Microscopic haematology: a practical guide for the laboratory 3e (c) 2011, Sydney, Elsevier Australia

icsh.org€¦ · Web view1 Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology Standardization and Grading Image S1: acanthocytes Abetalipoproteinaemia

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