ICRS NEWS v14(1)20041).2004.pdf · 2013-01-27 · protagonist versus antagonist role. In addition, the ICRS was pleased to coordinate its 2004 symposium with a satellite meeting on

There were 92 oral and 150 poster presentations at the meeting. These covered a range of topics including cannabinoid chemical structure activity relationships; regulation of endocannabinoid biosynthesis and inactivation; cannabinoid receptor structure, regulation, and signal transduction; vallinoid receptors; evolution of the cannabinoid system; neuromodulatory effects of endocannabinoids; memory and cognition; reproduction and brain development; and immunomodulatory activities. Two areas of major emphasis centered around the functional relevance of the endocannabinoid system and of the role of cannabinoids as potential therapeutic or analgesic agents. In this context symposium sessions addressed effects of cannabinoids on gastrointestinal, cardiovascular and other peripheral functions; neuroprotection and neurodegenerative disorders; the sensory nervous system and pain; stress, anxiety, and psychiatric disorders; food-intake and energy control; cancer; and potential novel roles for cannabinoid CB2 receptors in human osteoporosis.

As diverse as these topics were, they collectively shared a commonality in the high quality and caliber of their scientific content and professionaldelivery. This attests to the fact that the Student Judging Commitee handed out a record number (16) Scientific Achievement awards this year. Thanks go to Judging Committee Chair Cece

Headlines:

Letter from the Past President 1 The Minutes 3 Awards: Braude 4 Article: Puffenbarger 5-6 2003 ICRS Treasurer’s Report 7 Membership Directory 8-

Hillard, Tiziana Bisogno, Chris Fowler, Michelle Glass, George Kunos, Mauro Maccarrone, Brian Thomas and Michael Walker.

This year’s Symposium on the Cannabinoids was complemented by a Monothematic One-Day Meeting of the Società Italiana di Farmacologia. Five thematic sessions were held that focused on cannabinoids and cancer, novel roles for cannabinoid CB2 receptors, cannabinoids in the eye (in memory of Anna Porcella), immune-modulatory actions, and reward and interactions with other drugs of abuse. An innovative set of poster sessions also was held that centered on discussion of controversial issues. These included a discussion on the putative anandamide membrane transporter and on cannabinoids and cancer. Both sessions were highly successful and generated a vigorous debate among participants in a protagonist versus antagonist role. In addition, the ICRS was pleased to coordinate its 2004 symposium with a satellite meeting on “Targeted Lipidomics” that was sponsored through the National Institute on Drug Abuse. Dr. Rao Rapaka presented opening remarks at this satellite meeting and, along with Drs. Steve Gust and George Kunos, served as chair for symposium sessions.

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ICRS President: Vincenzo Di Marzo

President-Elect:

Daniela Parolaro

Past President: Guy Cabral

Secretary:

Patricia Reggio

Treasurer: Jenny Wiley

International Secretary:

Roger Pertwee

Executive Director: Richard Musty

L e t t e r f r o m t h e P a s t P r e s i d e n t

Continued on p.2

Newsletter of the

International Cannabinoid

Research Society

S u m m e r 2 0 0 4

Dear Colleagues,

This past year has proved to be truly outstanding in terms of growth of our society in membership and quality of scientific presentations at the 14th Annual Symposium on the Cannabinoids held at the Ariston Hotel in Paestum, Italy. We owe special thanks to this year’s Program Committee (Guy Cabral, Vincenzo Di Marzo, Javier Fernandez-Ruiz, Richard Musty, Roger Pertwee, Patricia Reggio, and Hassimi Traore) for scheduling a cutting-edge yet diverse program that dealt with a plethora of topics related to cannabinoids.

G u y C a b r a l

V o l u m e 1 4 , N u m b e r 1

We are particularly grateful to all of the members of the Italian Organizing Committee including Maurizio Bifulco, Vincenzo Di Marzo, Walter Fratta, Angelo Izzo, Mauro Maccarrone, Sabatino Maione, Daniela Parolaro, Luca Steardo, and Sergio Tanganelli for their efforts in coordinating arrangements for the 2004 symposium. Special thanks are in order to the Local Organizing Committee (Tiziana Bisogno, Vito De Novellis, Luciano De Petrocellis, and Carmela Saturnino) and all of the volunteers who assisted. Our Italian colleagues coordinated a superb and memorable meeting. Not only were we treated to an outstanding scientific venue that proceeded with minimal “glitches” but also we had the opportunity to savor a warm and congenial ambiance and tremendous hospitality.

Particularly enjoyable was the after-dinner concert on Friday night for which we owe many thanks to Vincenzo Di Marzo. We also are most grateful for all of the hard work of Adriana Oliviero-Di Marzo, Alessia Ligresti and Magda Bifulco in coordinating guided tours of the mozzarella manufacturers and visits to the Paestum temples, the Pompeii excavations, the Naples Historical center, and the Amalfi coast. Also, it goes without saying, that we owe many thanks to Diane Mahadeen and Rik Musty who provide a continuity and organizational oversight without which our society would not flourish. Finally, we would like to thank Diana St. Louis for her role as Abstract and Program Coordinator and our Webmaster Jason Schechter, as well as conference volunteer assistants Nicole Schechter, Heather Allen, Diana Chase, Teresa Roth, Chris Varvel and Steve Varvel.

We are most appreciative of the companies pledging financial support to our meeting: Sanofi-Synthelabo Recherche; Allergen, Inc.; Bristol-Myers Squibb Pharmaceutical Research Institute; GW Pharmaceuticals, Inc.; Novasite Pharmaceuticals, Inc.; Solvay Pharmaceuticals, Inc.; Astra Zeneca R & D,

Montreal; Glaxo Smith Kline; Alexis Corporation; Cayman Chemical Company; Eli Lilly & Company; Unilever R & D; Indena, S. P. A.; Pfizer, Inc.; Epitech, S. R. L.; Merck & Co., Inc.- USA; Microtech, S. R. L.; Shimadzu, S. R. L.; Elsohly Laboratories; and Tocris.

We are also thankful for financial sponsorship from university, government, and non-profit organizations. Generous support was provided by the Università degli Studi di Salerno; Università degli Studi dell’Insubria; Università degli Studi di Teramo; Società Italiana di Farmacologia; Consorzio Ferrara Ricerche; Instituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche; Università degli Studi di Napoli Federico II; Seconda Università degli Studi di Napoli; Università degli Studi di Roma “Tor Vergata”; and Associazione ERMES. We are particularly grateful for financial sponsorship from the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health, USA. We also thank NIDA for its sponsorship of a luncheon at which Dr. Steven Gust discussed “Research Funding Initiatives for Non-US Citizens/Permanent Residents.”

The generous financial support afforded by corporate and non-corporate sponsors allowed for the conduct of a highly successful meeting in which scholars from North America, South America, Europe, Asia, Australia, and New Zealand met to discuss the latest developments in cannabinoid research, renew friendships, and exchange scientific ideas as well as establish collaborative initiatives. Of paramount importance, the generous financial support that was made available allowed for granting of more than 80 travel awards to graduate students, post-doctoral fellows, and young investigators to attend and present at this year’s ICRS meeting. Furthermore, as a consequence of availability of such financial support, effective at our next annual meeting a financial award will be offered to an

Continued from p.1

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outstanding young investigator.

The ICRS has emphasized its commitment to encourage inclusion of young investigators and scientists as members and participants in our meetings. We were especially pleased that numerous students and post-doctoral fellows participated this year either in the poster sessions or at oral presentations. The caliber of research conducted by these young investigators was truly outstanding. The Society was also pleased to present this year’s Mechoulam Award to Murielle Rinaldi-Carmona and Francis Barth in recognition of their seminal work on the development of cannabinoid receptor antagonists.

So, another exciting and yet challenging annual meeting year has come to a close. We look forward to our next annual ICRS Symposium on the Cannabinoids to be held in Clearwater, Florida 24-28 June, 2005.

With Best Wishes for a

Successful Year,

2005 ICRS Symposium June 24 – 28, 2005

Hilton Clearwater Beach Resort Clearwater, Florida USA

The meeting was called to order by the Presiding President, Guy Cabral at 6:45 p.m. on June 25. The meeting was chaired by Rik Musty, Executive Director.

1) The first topic was an announcement of a new Award for a Young Investigator. It will be a cash award for an individual whose work has had impact on the cannabinoid field. A sub-committee will be formed to discuss the criteria (age, years after degree, etc.) for this award.

2) An announcement was made that the Treasurer’s report will be published in the next newsletter. (See related report below).

3) The next ICRS meeting was announced. Clearwater, Florida, 24-28 June 2005. Rik Musty described the site. A Hilton hotel (on the beach) has been reserved for the conference. The cost of the meeting should be similar to this year. A link will be placed on the web site with registration information.

be considered on an ad-hoc basis. A motion was made to approve an ICRS symposium next year at CPDD. It was seconded and passed.

6) Old Business. None.

7) New Business. Several program issues were raised. Ethan Russo proposed that the clinical session should not always be at the end of the conference. The program committee will take this into consideration when planning next year’s program. A discussion ensued about attendance at othersessions during this year’s conference. Vincenzo Di Marzo noted that while attendance varied at different sessions, there were always at least 150 participants present.

8) The “controversial issues” sessions (held at the poster sessions this year) will be a formal session next year. Attendees found this a valuable addition to the program.

9) The point was raised that previously published work had been presented at the meeting. There is currently a statement about submitting previously unpublished work in the call for abstracts. It was suggested that this point be emphasized again during next year’s call for abstracts. It may also be possible to shift published studies to poster presentations.

10) It was noted that presentations and posters were being photographed and videotaped. Rik and Guy stated that as of next year, no videos will be allowed in the sessions (both oral and poster).

There being no further business, the meeting was adjourned. Announcement of new officers was made at the Banquet Dinner as follows: President Vincenzo DiMarzo; President Elect Daniela Parolaro; Secretary Patricia Reggio; Treasurer Jenny Wiley, and Student Representative Liana Fattore.

Respectfully submitted,

M Mary Abood, I ICRS Secretary

3

4) ICRS 2006. Sites under consideration include University of Aberdeen in Scotland, Hungary (near Budapest) and Vienna, Austria. Presentations were given by Ruth Ross, Tibor Wenger and Hans Kress on the three venues. The Executive Committee (EC) will place details of the venues proposed on the Web page for ICRS members to vote on once the suitability of each venue is established.

The business meeting was adjourned to reconvene the following day. On June 26, the following topics were discussed:

5) ICRS Symposium at the College of Problems in Drug Dependence (CPDD) meeting. Guy Cabral described Marty Adler’s suggestion about hosting an ICRS Symposium at CPDD on the last day of their meeting next June 23. CPDD will be held in Orlando, Florida from June 18-23, 2005. ICRS members interested in attending this symposium would be eligible for day rates at CPDD on that day. As an aside, the ICRS also has day rates for the ICRS conference. The discussion that ensued centered around the idea that this

ICRS 2004

Business Meeting Minutes

Executive Newsletter Editor: Brian Thomas

Newsletter Editor: Diane Mahadeen

Design & Layout: Jason Schechter

Editorial Assistants:

John Huffman Thomas Klein Richard Musty Roger Pertwee

Photographers: Fred Gardner

Donald Wirtshafter

Home Web Site: http://cannabinoidsociety.org

Webmaster:

Jason Schechter

Office eMail: [email protected]

Office Telephone: 802.656.4189

Office FAX: 802.656.8783

Office Mailing Address: ICRS, Diane Mahadeen

55 Elsom Pky. So. Burlington, VT 05403

USA

ICRS Formal Address: Department of Psychology

John Dewey Hall University of Vermont Burlington, VT 05405

USA

Contact: Diana St. Louis Office Phone: 802.656.2670

Office Fax: 802.656.8783 eMail: [email protected]

U.S. Federal ID Number 03-0345758

Braude Receives Lifetime Achievement Award

4

(photo: DUNNO)

In recognition of Emeritus members who have made great contributions to the cannabinoid field, the ICRS Executive Committee created a Lifetime Achievement. The 2003 recipient of the award was one of our Society's founding members Monique Braude.

A graduate of the Sorbonne in Paris (B.S. in 1948), O Ohio State University (M.S. in 1954) and the n University of Maryland School of Medicine (Ph.D. in in 1963) Monique has been involved with ar marijuana and cannabinoid research studies o supported by the U.S. Government since the rl early 1970s.

After working for the Food and Drug ni Administration in its Psychiatric Unit, she moved to to NIMH in 1970 to its Narcotic and Drug Abuse I Division which, in 1974, became the National st Institute of Drug Abuse (NIDA). There, as Chief of th the Preclinical Section, she initiated and developed th the Biomedical Marihuana Program using grants n and contracts to pursue the necessary research on h the effects of cannabinoids.

results of these studies in the annual Reports to the U.S. Congress. During these years, the Marihuana Program expanded and Monique site visited most of the laboratories performing these studies. In 1974, with Dr. Stephen Szara, chief of the Biomedical branch, she organized one of the first large international conferences on the Pharmacology of Marihuana, which was published by Raven Press in 1976. She also represented the U.S. Government in international colloquia organized by the United Nations in Sweden, Israel and Holland.

Monique continued to be in charge of the preclinical studies of marijuana and cannabinoids until 1987 when she retired from the U.S. government. She continued to be active in the field and organized many symposia in ICRS, American Association for the Advancement of Science and Society of Toxicology meetings. She was elected in 1992 to be the second President of the newly formed ICRS. Her aim has been to support reliable, scientific studies of cannabinoids to protect the health and safety of the U.S. population.

Under contracts with Dr. Rosenkrantz of the Mason Research Institute, the acute and chronic toxicological studies of the major cannabinoids (delta-9-THC, CBD and CBN) were carried out. Results of these studies were immediately published in the Toxicology and Applied Pharmacology Journal between 1972 and 1979. From 1971 to 1980, Monique also reported the

By Diane Mahadeen

5

2004 ICRS Symposia and the Immune System

By Robyn Puffenbarger

The setting for the 2004 ICRS symposia was absolutely beautiful, and this year the scientific advances were impressive. This summary will try to do justice to the amazing breadth and depth of research covering the cannabinoid influences on the immune system reported this year in Paestum. Exciting research reported this year included three reports on multiple sclerosis (MS) from Malfitano et al., Ortega-Gutierrez et al., and Mestre et al. that focus on immune cells. These groups showed that the progression and severity of disease in their model was attenuated by, respectively, VR1/CB1 agonist arvanil, the potent anandamide (AEA) uptake inhibitor UCM707, and the endocannabinoid transport inhibitors OMDM1/2. Each group suggest from their studies on either T or microglial cells that the immunosuppressive properties of exogenous cannabinoid administration or raising the levels of endogenous cannabinioids may provide new therapeutic strategies for treating autoimmune diseases.

While considerable research efforts focused on lymphocyte populations including T cells, peripheral blood leukocytes (PBL’s), peripheral polymorphonuclear neutrophils (PMN’s), peripheral blood mononuclear cells (PBMC’s), leukemic cell lines and splenocytes, this year was notable for the lack of reports featuring pure B cell populations! T cell research featured two reports, first Gasperi et al. demonstrated that the fatty acid amide hydrolase (FAAH) promoter is differentially regulated by leptin and progesterone in T cells versus neuro-

blastoma cells. Then Rockwell and Kaminski showed that splenocytes treated with anandamide (AEA) or arachidonic acid (AA) produce less IL-2 than control cells and using selective COX-1 or COX-2 inhibitors, this reduction is due to the actions of both COX-1 and COX-2. In a SCID mouse model of AIDS infection, Baldwin et al. treated the mice with THC then found that expression of CCR5 and CXCR4 HIV co-receptors was increased compared to controls and more PBL’s were AIDS infected in ∆9-tetrahydrocannabinol (THC) treated cells versus controls. McHugh and Ross treated PMN’s with AEA and reported that AEA is not a chemoattractant but AEA does significantly inhibit PMN migration to N-formyl-methione-leucine-phenylalanine. Coopman et al. examined the changes in CB2 receptor levels by Western blotting in PBMC’s. After stimulation with staphylococcyl enterotoxin-B, CB2 levels were maintained for only 7-10 days and then the CB2 levels decreased, while stimulation with anti-CD3/CD28 induced strong expression of CB2 for up to14 days. Velasco et al. studied the apoptotic mechanism in leukemic cells lines and treatment with cannabinoid agonists involves ceramide synthesis, c-Jun N-terminal and P38 mitogen-activated protein kinase (MAP) activation, and downstream activation of caspase 3. Rao and Kaminksi showed with HPB-ALL cell line that THC treatment elevates intracellular calcium levels via CB2 through a putative receptor operated calcium channel. Finally, Duncan et al. examined the effects of Echinacea

purpurea extracts on CB2-/- and wt mice and noted that splenocytes from all mice had comparable levels of Con-A induced interferon-γ and tumor necrosis factor-α suggesting Echinacea purpurea effects are independent of CB2 receptor.

As in previous years, macrophages, monocytes, and microglia received considerable attention by a number of groups beginning with Roth et al. This group has shown that the monocyte to dendritic cell (DC) transition is inhibited by cannabinoid agonists and that HLA-DR, CD40, CD80, and CD86 expression are all decreased by THC or JWH-105 treatment. In agreement with the previous results, Vitiello et al. also examined the effects of AEA on the human monocyte to DC transition. They showed that AEA decreases the number of DC maturing from monocytes, AEA hinders LPS signalling pathways in DC, and these effects are cannabinoid and vanilloid receptor independent. Carrier et al. showed that microglial cell line proliferation is inhibited by THC and

(continued on p. 6)

6

cannabidiol (CBD) with concomitant decreases in p38 MAP kinase activity but no decreases in p42/p44 MAP kinase activity. Puffenbarger et al. presented an initial characterization of the murine CB2 promoter region in a macrophage-like cell line. To conclude the macrophage section, Ferguson and Buckely working with CB2-/- (knockout) mice showed the thioglycolate elicited macrophages have variations in morphology compared to wild type (wt) mice.

The rest of the reports on cannabinoid immunomodulatory effects used a variety of cell types that fit with a theme of inflammation. First, Sugiura et al. examined eosinophils and found that 2-AG but not AEA induced migration in human eosinophils. They also showed that 2-AG levels are increased in mouse ear after TPA treatment. Then, Massa et al. used CB1-/- mice to show that the CB1 knockout mice have a greater inflammatory response in models of colonic inflammation versus wt mice. Next, mast cells were used by two groups to examine the effects of cannabinoids. Jonsson and Fowler used a mast cell dependent inflammatory response in the mouse ear to show that the CB2 agonist JWH133 significantly decreased plasma extravasation compared to control while palmitoylisopropylamide, a palmitoylethanolamide (PEA) analog, had no effect. Vannacci et al. isolated guinea pig mast cells and treated them in the presence of the FAAH inhibitor PMSF. They showed that 2-arachidonyl glycerol and CP55,940decreased antigen dependent histamine release that was partially reversed by nitric oxide synthase inhibitor L-NAME. Using neutrophils, Nilsson and Jacobsson examined the effects of cannabinoids on IL-8 induced migration. In these experiments, pre-treatment with CP55,940 or WIN55,212 increased neutrophil migration compared to controls but AEA, PEA and OEA had no effect. Prause et al.gave healthy female volunteers THC (20 mg) or placebo (5 mg diazepam) and demonstrated that platelets from both groups had similar reactivity and glycoprotein II-b and III-a expression. Finally, in synovial fibroblasts obtained from patients undergoing knee replacement with rheumatoid arthritis, Burstein et al. saw that ajulemic acid reduced cell counts, altered prostaglandin expression to an anti-inflammatory profile, and changed IL-8 expression.

Taken individually, each of these studies represent a new piece of the knowledge base being created to determine the effects of cannabinoids on immune cells. Taken together, it seems we can conclude that cannabinoid compounds, cannabinoid receptors, and FAAH present novel targets for further research to prevent autoimmune activation in conditions such as MS and to modulate other diseases where inflammation plays a role.

Now, the long wait begins to see what new advances on the immunomodulatory effects of cannabinoids will come at ICRS in Florida, 2005!

2004 ICRS Symposia and the Immune System continued

”…this year the scientific advances were impressive.”

Cash Balance 1/1/2003 61,890

Income Membership Fees 10,695

Hotel and Registration Fees 163,160NIDA Grant Received in 2003 24,142

Other Grants 23,474Interest 552

Bank Credits 500 Total Income + Account Receivable 222,523

Operating Expenses

Office Supplies 2,996 Bank and Credit Card Fees 5,306

Newsletter and Membership Book Printing 1,727 Postage 3,984

Web Site and Internet Fees 2,147 Telephone 582

Consulting (D, Mahadeen) 24,500Consulting (D. St Louis) 910

Consulting (Misc) 2,271 Miscellaneous (Accountant, Legal) 112

Memberships 200 Insurance 6,154

Deposits for 2003 Conference Refunds to Members 250

Total Operating Expenses 51,139

Conference Expense NAV Canada Expense 150,812

Travel 1,375 Pre and Post-Doc Awards 1,600

International Student Awards 23,474NIDA Student Awards 24,142

Total 201,403

Total Cash + Income + Acct Receivable 284,413Total Expenses 252,542

Liabilities ( 1/31/2003 ) 22,000Fund Balance 2003 9,871

ICRS 2003

Treasurer’s Report

( in USD )

7

Mary Abood Forbes Norris ALS Res Cal Pacific Med Ctr 2351 Clay St San Francisco, CA 94115 415-600-3607 FAX: 415-563-7325 [email protected] Donald Abrams Hematology-Oncology San Francisco General Hospital Ward 84 995 Potrero Avenue San Francisco, CA 94110 415-206-4919 FAX: 415-502-2991 [email protected] Martin Adler Center for Substance Abuse Research Temple University School of Medicine 3400 N. Broad Street Philadelphia, PA 19140 215-707-3242 FAX: 215-707-1904 [email protected] Tania Aguado Biochemistry and Molecular Biology Complutense University Avenida Complutense s/n Madrid 28040 34913944668 FAX: 34913944672 [email protected] Abdulmonem Alhayani Anatomy and Cell Biology King Abdulaziz Univerisity PO BOX 1931 Jeddah, Jeddah 21441 96655688864 FAX: 9662640344320120 [email protected]

Claire Allison Physiology and Pharmacology University of Strathclyde Strathclyde Institute for Biomedical Sciences Taylor Street Glasgow G4 ONR 01415484031 [email protected] Sharon Anavi-Goffer Faculty of Dental Medicine The Hebrew University of Jerusalem Ein-kerem, Jerusalem 91102 97226758403 FAX: 97226757624 [email protected] Giovanni Appendino DISCAFF Università Piemonte Orien Via Bovio 6, Novara 28100 390321375744 [email protected] David Baker Neuroinflammation Institute of Neurology 1 Wakefield Streeet London WC1N 1PJ 442076794013 FAX: 442072786572 [email protected] Monica Bari Experimental Medicine Biochemical Science University of Rome Tor Vergata Via Montpellier, 1 Rome 00133 39672596385 FAX: 39672596385 [email protected]

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Francis Barth Exploratory Research Sanofi-Synthelabo Recherche 371 rue du Pr Blayac Montpellier Cedex 04 34184 33467106244 FAX: 33499775346 [email protected] Balapal Basavarajappa Analytical Psychopharmacology Nathan Kline Institute 140 Old Orangeburg Road Orangeburg, NY 10962 845-398-3234 [email protected] Natalia Battista Experimental Medicine Biochemical Science University of Rome Tor Vergata Via Montpellier, 1 Rome 00133 39672596385 FAX: 39672596385 [email protected] Guy Bewick Biomedical Sciences University of Aberdeen Institute of Medical Sciences Foresterhill, Aberdeen AB25 2ZD 441224555724 FAX: 441224555719 [email protected] Ranjit Kaur Bhogal Life Science Unilever R&D Colworth, Sharnbrook Bedford MK44 1LQ 441234248199 [email protected]

Maurizio Bifulco Scienze Farmaceutiche Università di Salerno via Ponte don Melillo Fisciano 84084 0817463110 FAX: 089962828 [email protected] Tiziana Bisogno ICB CNR Via C. Flegrei, 34 Pozzuoli 80078 390818675307 FAX: 390818041770 [email protected] Mark Black CNS Pharmacology Aventis Pharmaceuticals Route 202-206 Bridgewater, NJ 08807 908-231-5835 [email protected] Robert Blair Neurology Virginia Commonwealth University Box 980599 Richmond, VA 23298 804-828-3391 FAX: 804-828-6432 [email protected] Cristina Blázquez Biochemistry and Molecular Biology School of Biology Complutense University Ciudad Universitaria, s/n Madrid 28040 0034913944668 FAX: 0034913944672 [email protected]

Heather Bradshaw Psychology Brown University 89 Waterman St Providence, RI 02912 401-863-2605 [email protected] Chris Breivogel Pharmaceutical Sciences Campbell University PO Box 1090 Buies Creek, NC 27506 910-893-1702 FAX: 919-893-1697 [email protected] Rudolf Brenneisen Department of Clinical Research University of Bern Murtenstr. 35 Bern CH-3010 0041316328714 [email protected] Ros Brett Physiology and Pharmacology University of Strathclyde 27 Taylor Street Glasgow G4 0NR 441415484159 [email protected] Jonathan Brotchie TWRI / AIR University Health Network 399 Bathurst Street, MC 11-419 Toronto M5T 2S8 4166035369 FAX: 4166035447 [email protected]

Andrew Brown ADCP GlaxoSmithKline Third Avenue New Frontiers Science Park Harlow AL CM19 5AW 01279622243 FAX: 01279627567 [email protected] Nancy Buckley Biology CA State Polytech Univ 3801 W. Temple Ave. Pomona, CA 91768 909-869-4057 FAX: 909-869-4078 [email protected] Diep Burbridge Biological Sciences California State Polytechnic Univ. 3801 W. Temple Ave. Pomona, CA 91768 949-837-8307 [email protected] Sumner Burstein Biochemistry and Molecular Pharmacology U Mass Med School 364 Plantation St. Worcester, MA 01605 508-856-2850 [email protected] Bernard Calandra Exploratory Research Sanofi-Synthelabo Recherche 371, rue Pr. J. Blayac MONTPELLIER Cedex 04 34184 33499775339 FAX: 33499775346 [email protected]

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Kenneth Carlson Metabolic Research Bristol-Myers Squibb 311 Pennington-Rocky Hill Road Pennington, NJ 08534 609-818-4606 [email protected] Guaza Carmen Neural Plasticity Cajal Institute Avda Dr Arce, 37 Madrid 28002 34915854742 FAX: 34915854754 [email protected] Erica Carrier Pharmacology and Toxicology Medical College of Wisconsin 8701 Watertown Plank Rd Milwaukee, WI 53226 414-456-8620 FAX: 414-456-6545 [email protected] Maria Grazia Cascio ICB CNR via CAMPI FLEGREI 34 POZZUOLI 80078 0818675191 FAX: 0818041770 [email protected] Anna Castañé CEXS Univesitat Pompeu Fabra Dr.Aiguader 80 Barcelona 08003 34935422831 [email protected]

Paolo Cavallo Dipartmento di Scienze Farmaceutiche Università degli Studi di Salerno via Ponte Don Melillo Fisciano (SA) 84135 39089962827 [email protected] Victoria Chapman School of Biomedical Sciences University of Nottingham E Floor, Medical School Queen's Medical Centre Nottingham Ng72UH 01158549092 [email protected] June Chen Biological Sciences Allergan 2525 Dupont Drive Irvine, CA 92623-9534 714-246-5939 FAX: 714-246-5578 [email protected] Constance Chu Psychology Brown University 89 Waterman Street Providence, RI 02906 401-258-3266 [email protected] Arianna Colombo DBSF, Pharmacology Section University of Insubria Via A da Giussano 12 Busto Arsizio 21052 390331339425 FAX: 390331339459 [email protected]

David Compton General Toxicology Schering-Plough Res. Inst. 144 Route 94, PO Box 32 Lafayette, NJ 07848-0032 973-940-4190 FAX: 973-940-4341 [email protected] Chris Connolly Pathology and Neuroscience University of Dundee Ninewells Medical School Dundee DD1 9SY 01382632527 FAX: 01382667120 [email protected] Karen Coopman Pharmacy and Pharmacology University of Bath Claverton Down Bath BA2 7AY 441225384435 [email protected] Barbara Costa Depatartment of Biotechnology and Bioscience University of Milano-Bicocca Piazza della Scienza 2 Milano 20126 00390264484422 FAX: 00390264483540 [email protected] Angela Coutts Biomedical Sciences University of Aberdeen Institute of Medical Sciences Foresterhill, Aberdeen AB25 2ZD 441224555912 [email protected]

Melinda Cox Pharmacology and Toxicology Virginia Commonwealth University Box 980613, MCV Station Richmond, VA 23298 804-828-8446 [email protected] Tiziano Croci Drug Discovery Sanofi-Synthelabo SpA Via GB Piranesi 38 Milan 20137 00390273942414 FAX: 00390273942453 [email protected] Nives Daddario DISCAFF università del piemonte orientale via bovio 6 novara 28100 3398054777 [email protected] Tanya Daigle Physiology and Biophysics University of Washington 7026 23rd Ave. Seattle, WA 98115 206-985-8165 [email protected] Braida Daniela Farmacologia CTM Università di Milano Via vanvitelli 32 Milano 20129 00390250317041 FAX: 00390250317036 [email protected]

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Nissar Darmani Pharmacology KCOM/ATSU 800 West Jefferson St. Kirksville, MO 63501 660-626-2326 FAX: 660-626-2728 [email protected] Andrew Davies Business Development Settle Associates Ltd 99 Lime Grove, Doddinghurst Brentwood CM15 0QX 00441277824981 FAX: 00448700940609 [email protected] Eva de Lago Biochemistry and Molecular Biology Complutense University Ciudad Universitaria s/n Madrid 28040 34913941450 FAX: 34913941691 [email protected] Luciano De Petrocellis ERG Cibernetica "E. Caianiello" via Campi Flegrei 34 Pozzuoli 80078 390818675173 [email protected] Andria Degia HPRU Medical Research Centre University of Surrey Egerton Road Guildford GU2 7XP 01483689797 FAX: 01483689790 [email protected]

Dirk Demuth Department of Biosciences University of Hertfordshire College Lane Hatfield AL10 9AB 4401707283328 [email protected] Suzanne Desjardins Drug Strategy and Control Health Canada 123 Slater St., A.L. 3503B Ottawa K1A 1B9 6139464223 FAX: 6139522196 [email protected] Dale Deutsch Biochemistry and Cell Biology SUNY at Stony Brook Life Sciences Bldg Stony Brook, NY 11794-5215 631-632-8595 FAX: 631-632-8575 [email protected] William Dewey Phamacology and Toxicology Virginia Commonwealth University 1112 East Clay St., POBox 980613 Richmond, VA 23102-0613 804-827-0375 FAX: 804-827-1548 [email protected] Vincenzo Di Marzo Institute of Biomolecular Chemistry National Research Council Via Campi Flegrei 34 Pozzuoli (NA) 80078 390818675093 [email protected]

Ines Díaz-Laviada Biochemistry University of Alcala School of Medicine Alcala de Henares 28871 34918855141 [email protected] Ahmet Dogrul Pharmacology GATA Etlik, Ankara 06018 09031232830483 [email protected] Alison Drysdale Biomedical Sciences University of Aberdeen Foresterhill, Aberdeen AB25 2ZD 4401224555775 FAX: 4401224555719 [email protected] Marnie Duncan School of Biomedical Sciences University of Nottingham Queens Medical Centre Nottingham ng7 2uh 01159249924 [email protected] Trisha Duncan Biology CSU Pomona 26798 N. Claudette St., Apt. 337 Canyon Country, CA 91351 661-298-9427 [email protected] Michaela Egertová Biological Sciences QMUL Mile End Rd London E1 4NS 442078825290 FAX: 442089830973 [email protected]

Maurice Elphick Biological Sciences QMUL Mile End Rd London E1 4NS 442078825290 FAX: 442089830973 [email protected] Mahmoud ElSohly President ElSohly Laboratories 5 Industrial Park Drive Oxford, MS 38655 662-236-2609 FAX: 662-234-0253 [email protected] Rhian Evans Biomedical Sciences University of Aberdeen Institute of Medical Sciences Foresterhill, Aberdeen AB25 2ZD 01224555705 [email protected] Paola Fadda Neuroscience University of Cagliari Cittadella Universitaria SS 554 km 4,500 Monserrato (Cagliari) 09042 3907067543264332 FAX: 390706754312 [email protected] Katherine Falenski Pharmacology and Toxicology Virginia Commonwealth University 1217 East Marshall Street, Room 609 Richmond, VA 23298 804-828-3391 FAX: 804-828-6432 [email protected]

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Liana Fattore Department of Neuroscience CNR Inst. of Neuroscience Cittadella Universitaria di Monserrato Monserrato - Cagliari ID 09042 390706754327 FAX: 390706754312 [email protected] Tanya Ferguson Biology Cal Poly Pomona 3801 West Temple Avenue Pomona, CA 91768 909-869-4057 [email protected] Javier Fernandez-Ruiz Biochemistry Complutense University Ciudad Universitaria s/n Madrid 28040 34913941450 FAX: 34913941691 [email protected] Luca Ferraro Clinical and Experimental Medicine Section of Pharmacology University of Ferrara Via Fossato di Mortara 17-19 Ferrara 44100 00390532291212 FAX: 00390532291205 [email protected] Antonio Ferreira Department of Chemistry The University of Memphis 3744 Walker Avenue Memphis, TN 38152 901-678-1423 FAX: 901-678-3447 [email protected]

Filomena Fezza Experimental Medicine Biochemical Sciences University of Rome Tor Vergata Via Montpellier, 1 Rome 00133 39672596385 FAX: 39672596385 [email protected] David Finn Institute of Neuroscience University of Nottingham School of Biomedical Sciences Queen's Medical Centre Nottingham NG7 2UH 441159709462 FAX: 441159709259 [email protected] Tung Fong Metabolic Disorders Merck PO Box 2000 80M-213 Rahway, NJ 07065 732-594-6711 [email protected] Dale Fortin Pharmacology University of Connecticut Health Center 263 Farmington Ave. MC6125 Farmington, CT 06030 860-679-4902 [email protected] Christopher Fowler Pharmacology & Clinical Neuroscience Umea University Umeå SE90187 46907851510 [email protected]

Maria Elena Francisco JLC Biomed. Biotech Research Inst. North Carolina Central University 700 George St. Durham, NC 27707 919-530-7029 FAX: 919-530-7760 [email protected] Steven Franklin JLC Biomed. Biotech Research Inst. North Carolina Central University 700 George St. Durham, NC 27707 919-530-7832 FAX: 919-530-7760 [email protected] Walter Fratta Neuroscience University of Cagliari Cittadella Universitaria SS 554 km 4,500 Monserrato (Cagliari) 09042 3907067543134312 FAX: 390706754312 [email protected] Ester Fride Behavioral Sciences and Molecular Biology College of Judea and Samaria PO Box 3, Ariel AL 44837 97239066295 FAX: 97239066690 [email protected] Peter Fried Psychology Carleton University 1125 Colonel By Drive Ottawa K1S 5B6 6135202676 FAX: 6135203667 [email protected]

Mariella Fusco Pharmacology Research & Innovation Soc. Coop. a r.l. Via Svizzera, 16 Padova 35127 390498705062 FAX: 390498706696 [email protected] Ruth Gallily Immunology Hebrew University Ein Kerem Campus Jerusalem 91120 97226758712 [email protected] Eliot Gardner Neuropsychopharmacology Section National Institute on Drug Abuse 5500 Nathan Shock Drive Baltimore, MD 21224 410-550-1634 FAX: 410-550-5172 [email protected] Valeria Gasperi Experimental Medicine Biochemical Sciences University of Rome Tor Vergata Via Montpellier, 1 Rome 00133 39672596385 FAX: 39672596385 [email protected] Ellen B. Geller Center for Substance Abuse Research Temple University School of Medicine 3400 N. Broad St. Philadelphia, PA 19140 215-707-5307 [email protected]

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Tonya Gerald JLC Biomed Biotech Research Inst. North Carolina Central University 700 George St. Durham, NC 27707 919-530-7883 FAX: 919-530-7760 [email protected] Gregory Gerdeman Pharmacology University of Arizona 1501 N. Campbell Ave. Tucson, AZ 85724 520-626-2188 [email protected] Sherrye Glaser Medical Department Brookhaven National Lab Building 490, 30 Bell Rd Upton, NY 11973 631-344-2219 FAX: 631-344-5311 [email protected] Michelle Glass Pharmacology and Liggins Institute University of Auckland PO Box 90210 Auckland, NZ 649373759982348 FAX: 6493737497 [email protected] Maria Gomez Biochemistry Complutense University Ciudad Universitaria s/n Madrid 28040 34913941450 FAX: 34913941691 [email protected]

Sara Gonzalez Biochemistry Complutense University Ciudad Universitaria s/n Madrid 28040 34913941450 FAX: 34913941691 [email protected] Salvatore Grasso Associazoione per la Cannabis Terapeutica Associazione per la Cannabis Terapeutica viale Campania 14 Palermo 90144 3991527129 [email protected] Pascale Grenard INSERM U581 Hôpital Henri Mondor 51 av. du Mal. de Lattre de Tassigny Créteil 94010 [email protected] Claudia Grimaldi Scienze Farmaceutiche Università Degli Studi Di Salerno Via Ponte Don Melillo Fisciano (Sa) 84084 089962516 [email protected] Fabio Guagnini Pharmacology Sanofi-Synthelabo SpA Via GB Piranesi 38 Milan 20137 00390273942414 FAX: 00390273942453 [email protected]

Carmen Guaza Neural Plasticity Cajal Institute Avda Dr Arce 37 Madrid 28002 34915854742 FAX: 34915854754 [email protected] Geoffrey William Guy Executive Chairman GW Pharmaceuticals plc Porton Down Science Park Salisbury, Wiltshire SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected] Manuel Guzmán Biochemistry and Molecular Biology Complutense University Avenida Complutense, s/n Madrid 28040 34913944668 FAX: 34913944672 [email protected] Robert Hampson Physiology and Pharmacology Wake Forest University School of Medicine Medical Center Blvd Winston-Salem, NC 27157-1083 336-716-8541 FAX: 336-716-8538 [email protected] Louis Harris Pharmacology and Toxicology Virginia Commonwealth University 1112 East Clay Street, PO Box 980027 Richmond, VA 23298-0027 804-828-2075 FAX: 804-828-1532 [email protected]

Carl Haslam ADCP Glaxosmithkline New Frontiers Science Park Third Avenue Harlow CM19 5AW 441438764896 FAX: 441438768017 [email protected] Jeffrey Hergenrather Private Practice 7969 Kennedy Rd. Sebastopol, CA 95472 707-484-7720 FAX: 707-823-3070 [email protected] Heike Hermann Molecular Genetics of Behaviour MPI for Psychiatry Kraepelinstr. 2-10 Munich 80804 08930622646 [email protected] Anita Hermann Biochemistry and Cell Biology SUNYSB Life Sciences Building 335b Stony Brook, NY 11794 631-632-6772 [email protected] Matthew Hill Psychology University of British Columbia 2136 West Mall Vancouver V5Z 6T1 6048222952 [email protected]

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Cecilia Hillard Pharmacology Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226 414-456-8493 FAX: 414-456-6545 [email protected] Wing Sze (Vanessa) Ho Pharmacology and Toxicology Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226 414-456-8620 [email protected] Alex Hoffman Cellular Neurobiology Branch National Institute on Drug Abuse 5500 Nathan Shock Drive Baltimore, MD 21228 410-550-6565 ext.143 FAX: 410-550-1621 [email protected] Andrea Hohmann Psychology University of Georgia Neuroscience and Behavior program Psychology Building Athens, GA 30602-3013 706-542-2252 FAX: 706-542-3275 [email protected] Sandra Holt Pharmacology Pharmacology and Clinical Neuroscience Umeå universitet Umeå 90187 46907851590 [email protected]

Allyn Howlett JLC Biomed. Biotech. Research Inst. North Carolina Central University 700 George St. Durham, NC 27707 919-530-7032 FAX: 919-530-7760 [email protected] Shu-Jung Hu Psychology Brown University 89 Waterman Street Providence, RI 02912 401-863-2727 FAX: 401-863-1300 [email protected] Susan Huang Neuroscience Brown University 89 Waterman St., Box 1853 Brown University Providence, RI 02912 400-186-3272 ext.7 [email protected] Marilyn Huestis Chemistry and Drug Metabolism Intramural Research Program NIDA, NIH 5500 Nathan Shock Dr. Baltimore, MD 21224 410-550-2711 FAX: 410-550-2468 [email protected] John Huffman Department of Chemistry Clemson University Clemson, SC 29634-0973 864-656-3133 FAX: 864-656-6613 [email protected]

Basalingappa Hungund Analytical Psychopharmacology Nathan Kline Institute 140 Old Orangeburg Rd Orangeburg, NY 10983 845-398-5452 FAX: 845-398-5451 [email protected] Irma Iacuzzo Scienze Farmaceutiche Università Degli Studi Di Salerno Via Ponte Don Melillo Fisciano (Sa) 84084 089962516 [email protected] Stefania Iosuè Pharmacology, Chemotherap University of Milan Via Vanvitelli 32 Milan 20129 390250317041 FAX: 390250317036 [email protected] Stig Jacobsson Pharmacology and Clinical Neuroscience Umea University Umea SE-90187 46907852713 FAX: 46907852752 [email protected] Toby Jarbe Psychology Temple University 265-67 Weiss Hall, 1701 North 13th St Philadelphia, PA 19122 215-204-6977 FAX: 215-204-5539 [email protected]

Abbas Jarrahian Pharmaceutical Sciences Butler University 4600 Sunset Avenue Indianapolis, IN 46208 317-940-9007 FAX: 317-940-6171 [email protected] Tomi Jarvinen Dept. Pharm. Chem. Univ. of Kuopio Harjulantie 1 Kuopio FIN 70211 35817162468 [email protected] Maulik Jhaveri Biomedical Sciences University of Nottingham E-Floor, Queens Medical Centre Clifton Boulevard Nottingham NG7 2UH 00441159709480 FAX: 00441159709259 [email protected] Kent-Olov Jonsson Pharmacology and Clinical Neuroscience Umeå universitet Pharmacology, Building 6B Umeå SE-90187 46907851590 [email protected] Boris Julien INSERM U581 Hôpital Henri Mondor 51 av. du Mal. De Lattre de Tassigny Créteil 94010 Créteil 0149813538 [email protected]

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Martin Kaczocha Biochemistry and Cell Biology Stony Brook University Life Sciences, Room 350 Stony Brook, NY 11794-5215 631-632-6772 [email protected] Markus Kathmann Pharmacology University of Bonn Reuterstr. 2B Bonn D-53113 49228739558 FAX: 49228735404 [email protected] Christopher Kearn Anesthesiology University of Washington Box 356540 Seattle, WA 98195 206-616-2669 [email protected] David Kendall School of Biomedical Science Univ of Nottingham D floor, Medical School Queen's Medical Centre Nottingham AL NG72UH 01159709482 [email protected] Iryna Khasabova Oral Sciences University of Minnesota 515 Delaware St. S.E. 17-252 Moos Tower Minneapolis, MN 55455 612-624-2470 FAX: 612-626-2651 [email protected]

Tim Kirkham Psychology University of Reading Earley Gate Whiteknights Reading RG6 6AL 01183787544 FAX: 01183786715 [email protected] Thomas Klein Med Micro and Immunol, MDC Box 10 University of South Florida 12901 Bruce Downs Blvd. Tampa, FL 33612 813-974-2502 FAX: 813-974-4151 [email protected] Lea Knight Chemistry Clemson University 110 Azalea Dr Clemson, SC 29631 864-656-6847 FAX: 864-656-6613 [email protected] James Koch Psychology Univ WI Oshkosh 800 Algoma Blvd CF 20 Oshkosh, WI 54901 920-424-2303 FAX: 920-424-1204 [email protected]

Natalya Kogan Medicinal Chemistry and Natural Products The Hebrew University of Jerusalem Hebrew University, Medical Faculty, Ein -Kerem Campus Jerusalem 92110 97226758635 FAX: 97227657076 [email protected] Geoffray Labar Med. Chem. Université de Louvain Mounier avenue 73 UCL-CMFA 73.40 Brussels 1200 3227647341 FAX: 3227647363 [email protected] Chiara Laezza Istituto di endocrin. e oncologia sperimentale CNR Via Pansini 5 Napoli 80131 0817463110 [email protected] Didier Lambert Medicinal Chemistry Université de Louvain Mounier avenue 73 UCL-CMFA 7340 Brussels 1200 3227647347 FAX: 3227647363 [email protected]

Marco Landi Pharmacology Sanofi-Synthelabo SpA Via GB Piranesi 38 Milan 20137 00390273942414 FAX: 00390273942453 [email protected] Richard Langham School of Pharmacy Curtin University GPO Box U1987 Perth 6845 61892667418 FAX: 61893643986 [email protected] Joohyung Lee Applied and Interventional Research Toronto Western Hospital 399 Bathurst, Room MP12-303 Toronto m5t2s8 141660358003472 FAX: 14166035447 [email protected] Cécile Leleux Med.Chem. Université de Louvain Mounier 73 UCL-CMFA 73.40 Brussels 1200 3227647345 FAX: 3227647363 [email protected] Isobel Lever Neural Plasticity Unit University College London Institute of Child Health 30 Guilford Street London WC1N 1EH 442079052704 [email protected]

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F. Markus Leweke Dept. of Psychiatry and Psychotherapy University of Cologne Joseph-Stelzmann-Str. 9 Cologne 50931 492214787250 FAX: 492214784876 [email protected] Deborah Lewis Pharmacology & Toxicology Medical College of Georgia 1120 15th Street Augusta, GA 30912 706-721-6345 FAX: 706-721-2347 [email protected] Aron Lichtman Pharmacology and Toxicology Virginia Commonwealth University PO Box 980613 Richmond, VA 23298-0613 804-828-8480 FAX: 804-828-2117 [email protected] Alessia Ligresti Istituto di Chimica Biomolecolare Consiglio Nazionale delle Ricerche Via Campi Flegrei, 34 Comprensorio Olivetti Pozzuoli, Napoli 80078 390818675191 FAX: 390818041770 [email protected] Gregory I. Liou Ophthalmology Medical College of Georgia 1120 15th Street Augusta, GA 30912 706-721-4599 FAX: 706-721-7913 [email protected]

Yunguang Liu Pharmacology Medical College of Georgia 1120 15th Street, CB3515 Augusta, GA 30912 706-721-6346 FAX: 706-721-2347 [email protected] Leonora Long Pharmaceutical Biology and Pharmacology Victorian College of Pharmacy 381 Royal Pde Parkville 3052 61399039076 FAX: 61399039638 [email protected] Visitacion López-Miranda Health Sciences, Unit of Pharmacology Universidad Rey Juan Carlos Avda. Atenas s/n Alcorcón 28922 34914888854 FAX: 34914888831 [email protected] María Luz López-Rodríguez Química Orgánica I Universidad Complutense Avda Complutense s/n Madrid 28040 34913944239 FAX: 34913944103 [email protected] Sophie Lotersztajn INSERM U581 Hôpital Henri Mondor 51 av. du MaL. de LAttre de Tassigny Créteil 94010 Créteil 0149813534 [email protected]

Dai Lu School of Pharmacy University of Connecticut 372 Fairfield Road Storrs, CT 06269 860-486-4854 FAX: 860-486-3089 [email protected] Frank Lucido Family & General Practice (private practice) 2300 Durant Ave Berkeley, CA 94704 510-848-0958 FAX: 510-658-1265 [email protected] Thomas Lundqvist Lund University Hospital Drug Addiction Treatment Kyrkogatan 19 Lund 22222 46462117579 FAX: 4646152511 [email protected] Carl Lupica Neurophysiology Section NIH/ NIDA 5500 Nathan Shock Drive Baltimore, MD 21224 410-550-6565 ext.132 FAX: 410-550-1621 [email protected] Beat Lutz Molecular Genetics of Behavior Max-Planck-Institute of Psychiatry Kraepelinstrasse 2-10 Munich 80804 498930622640 FAX: 498930622610 [email protected]

Mary Lynch Faculty of Medicine Pain Management Unit Fourth Floor Dickson, QEIIHSC 5820 University Avenue Halifax B3H1V7 9024736428 FAX: 9024734126 [email protected] Mauro Maccarrone Biomedical Sciences University of Teramo Piazza Aldo Moro 45 Teramo 64100 390861266875 FAX: 390861412583 [email protected] Marco Macchia Scuienze Farmaceutiche University of Pisa Via Bonanno 6 Pisa 56126 3950500209 FAX: 3905040517 [email protected] Orsolya Magyar Psychology University of British Columbia 2136 West Mall Vancouver V6T 1Z4 6048227550 [email protected] Anuradha Mahadevan Group Leader Organix, Inc. 240 Salem Street Woburn, MA 01801 781-932-4142 FAX: 781-933-6695 [email protected]

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Anna Maria Malfitano Scienze Farmaceutiche Università Degli Studi Di Salerno Via Ponte Don Melillo Fisciano (Sa) 84084 089962516 [email protected] Dan Malone Pharmaceutical Biology & Pharmacology Monash University 381 Royal Parade Parkville 3052 61399039576 FAX: 61399039638 [email protected] Yehoshua Maor Medicinal Chemistry The Hebrew University of Jerusalem Mekor Haim 15, Apt. 11 Jerusalem 93465 97226757549 [email protected] Silvia Marinelli Neuroscience IRCCS Santa Lucia Foundation Via Ardeatina, 306 Rome 00179 390651501382 FAX: 390651501384 [email protected] Giovanni Marsicano Genetics of Behaviour Max-Planck Institute Kraepelinstr 4 Munich 80804 498930622626 [email protected]

Billy Martin Pharmacology & Toxicology Virginia Commonwealth University 410 N 12th Street, Rm 746 P.O. Box 980613 Richmond, VA 23219-0613 804-828-8407 FAX: 804-828-0377 [email protected] Jose Martinez-Orgado Pediatrics Fundacion Hospital Alcorcon Budapest, 1 Alcorcon 28029 34916219968 [email protected] Federico Massa Molecular Genetics of Behaviour Max Planck Institute for Psychiatry Kraepelinstrasse 2-10 Munich D-80804 00498936622626 [email protected] Isabelle Matias ICB CNR Ex-compressorio Olivetti Via Campi Flegrei 34 Pozzuoli (Napoli) 80078 390818675193 [email protected] Kirk Maxey Administration Cayman Chemical Company 1180 E. Ellsworth Road Ann Arbor, MI 48108 734-971-3335 FAX: 734-971-3641 [email protected]

Sean McAllister CPMCRI CPMC 2351 Clay St., Suite # 416 San Francisco, CA 94115 415-600-3606 FAX: 415-563-7325 [email protected] Kathleen McCoy Microbiology and Immunology Virginia Commonwealth University 1217 E Marshall St. Med Sci Bldg, Room 228 Richmond, VA 23298 804-828-2305 [email protected] Douglas McHugh Biomedical Sciences University of Aberdeen Institute of Medical Sciences Foresterhill Aberdeen AB25 2ZD 0122455705 [email protected] Peter McLaughlin Psychology University of Connecticut 406 Babbidge Road Storrs, CT 06269-1020 860-486-4768 FAX: 860-486-2760 [email protected] John McPartland School of Health UNITEC Private Bag 92025 Mt. Albert Auckland AA 1004 64981543218271 FAX: 6498154373 [email protected]

Aimee McRae Psychiatry Medical University of South Carolina 67 President St. Charleston, SC 29425 843-792-5216 FAX: 843-792-3982 [email protected] Alice Mead Medical Affairs GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected] Raphael Mechoulam Medical Faculty Hebrew University Ein Kerem Campus Jerusalem 91120 97226758634 FAX: 97226757076 [email protected] Miriam Melis Neuroscience "B.B. Brodie" University of Cagliari Cittadella Universitaria di Monserrato SS 554 km 4,5 Monserrato 09042 390706754340 FAX: 390706754320 [email protected] Alberto Minassi Discaff Università del Piemonte Orientale Via Bovio 6 Novara 28100 3282478257 [email protected]

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Francisco Molina-Holgado Neurology Unit, CVS University of Cambridge Madingley Road Cambridge CB3 OES 4401223765683 FAX: 4401223337610 [email protected] Areles Molleman Biosciences University of Hertfordshire CP Snow Building, College Lane Hatfield AL10 9AB 441707285255 FAX: 441707285046 [email protected] Krisztina Monory Genetics of Behaviour Max Planck Institute of Psychiatry Kraepalinstr. 2-16 Munich D-80804 498930622626 FAX: 498930622642 [email protected] Bob Moore Pharmaceutical Sciences University of Tennessee 847 Monroe Ave. Rm. 327D Memphis, TN 38103 901-448-6085 FAX: 901-448-6828 [email protected] Fabricio Moreira Pharmacology University of Sao Paulo Av Bandeirantes, 3900 Ribeirao Preto 14049-900 55166023209 [email protected]

Enrico Morera Studi Farmaceutici Università di Roma I P.le A. Moro 5 Roma 00185 39649913612 FAX: 396491491 [email protected] Jun Morishita Department of Biochemistry Kagawa University School of Medicine 1750-1 Ikenobe Miki 761-0793 81878912104 FAX: 81878912105 [email protected] Giulio Muccioli Med.Chem. Université de Louvain Avenue Mounier 73 UCL-CMFA 73.40 Brussels 1200 3227647341 FAX: 3227647363 [email protected] Somnath Mukhopadhyay JLC Biomed. Biotech. Research Inst. North Carolina Central University 700 George St. Durham, NC 27707 919-530-7762 FAX: 919-530-7760 [email protected] Eduardo Munoz Biologia Celular, Fisiologia e Inmunologia Facultad de Medicina Avda Conde de Vallellano 13, 1 Cordoba 14004 34957218267 FAX: 34057218229 [email protected]

Anna Lisa Muntoni B.B. Brodie Dept. of Neuroscience CNR Inst. of Neuroscience Cittadella Universitaria di Monserrato Monserrato (CA) 09042 390706754327 FAX: 390706754320 [email protected] Richard Musty Psychology University of Vermont John Dewey Hall Burlington, VT 05405 802-656-2670 FAX: 802-865-8783 [email protected] Ntsang Nebane Pharmacology and Toxicology University of Louisville Baxter Building Room 224 570 South Preston Street Louisville, KY 40202 502-852-2404 FAX: 502-852-2492 [email protected] Jason Niehaus Pharmacology and Toxicology Medical College of Georgia 1120 15th St, CB-3515 Augusta, GA 30912-2300 706-721-6346 [email protected] Olov Nilsson Pharmacology and Clinical Neuroscience Umeå universitet By 6B Umeå SE 90187 46907851097 [email protected]

Luis Alfonso Núñez Domínguez Psiquiatría Clínica San Francisco Javier Avenida Baja Navarra, 52 Pamplona MD 31002 948231600 [email protected] Yasuo Okamoto Biochemistry Kagawa University School of Medicine 1750-1 Ikenobe Miki 761-0793 81878912104 [email protected] Giorgio Ortar Studi Farmaceutici Università di Roma I P.le A. Moro 5 Roma 00185 39649913612 FAX: 396491491 [email protected] Silvia Ortega-Gutiérrez Química Orgánica I Universidad Complutense Avenida Complutense s/n Madrid 28040 34913944894 FAX: 34913944103 [email protected] Saoirse O'Sullivan School of Biomedical Sciences University of Nottingham E Floor Queens Medical Centre Nottingham NG72UH 00447729481802 [email protected]

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Paola Massi Pharmacology University of Milan Via Vanvitelli 32 Milan 20129 390250317044 FAX: 390250317036 [email protected] Nisha Parihar Biomedical Science Unversity of Aberdeen Foresterhill Aberdeen AB25 2ZD 01224555775 FAX: 01224555719 [email protected] Teija Parkkari Department of Pharmaceutical Chemistry University of Kuopio P.O.Box 1627 Kuopio 70100 35817162431 FAX: 35817162456 [email protected] Daniela Parolaro DBSF, Center Neuroscience University of Insubria via A. da Giussano 10 Busto Arsizio 21052 390331339417 FAX: 390331339459 [email protected] Maria Ruth Pazos Laboratorio de Apoyo a la Investigacion Fundacion Hospital Alcorcon c/ Budapest 1 Alcorcon 28922 34916219846 [email protected]

Simona Pegorini Pharmacology, Chemotherapy University of Milan Via Vanvitelli 32 Milan 20129 390250317041 FAX: 390250317036 [email protected] Simona Perra B.B. Brodie Neuroscience University of Cagliari Cittadella Universitaria SS 554 km 5,4 Monserrato 09042 390706754340 FAX: 390706754320 [email protected] Roger Pertwee Director of Pharmacology GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected] Lynda Peterson JLC Biomed. Biotech. Research Inst. North Carolina Central University 700 George St Durham, NC 27707 919-530-7029 FAX: 919-530-7760 [email protected] Robert Picone Center for Drug Discovery University of Connecticut 372 Fairfield Way U2092 Storrs, CT 06269-2092 860-405-9286 [email protected]

Hal Pinnick Chemistry Department of Chemistry and Physics Purdue University -- Calumet 2200 169th Street Hammond, IN 46323 [email protected] Rossana Pisani DBSF-Dept. of Struct. and Funct. Biol. University of Insubria Via J.H. Dunant, 3 Varese 21100 390332421318 FAX: 390332421300 [email protected] Simona Pisanti Scienze Farmaceutiche Università Degli Studi Di Salerno Via Ponte Don Melillo Fisciano (Sa) 84084 089962516 [email protected] Marco Pistis B.B. Brodie Neuroscience University of Cagliari Monserrato Cagliari 09042 390706754324 [email protected] Bettina Platt School of Medical Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD 441224555741 FAX: 441224555719 [email protected]

Giuseppe Portella Biologia Patologia Cellulare e Molecolare Università di Napoli Federico II Via Pansini 5 Napoli 80131 390817463052 FAX: 390817463037 [email protected] Judith Pratt Physiology and Pharmacology University of Strathclyde 27 Taylor St Glasgow G4 0NR 01415482123 [email protected] Martin Price Biomedical Sciences University of Aberdeen Institute of Medical Sciences Foresterhill Aberdeen AB25 2ZD 01224555744 [email protected] Gareth Pryce Neuroinflammation Institute of Neurology 1 Wakefield Street London WC1N 1PJ 442076794085 FAX: 442072786572 [email protected] Robyn Puffenbarger Biology Bridgewater College 402 E. College Street Bridgewater, VA 22812 540-828-5713 FAX: 540-828-5661 [email protected]

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David Rademacher Pharmacology and Toxicology Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226 414-456-8620 FAX: 414-456-6545 [email protected] Jose Antonio Ramos Biochemistry (Faculty of Medicine) Complutense University Ciudad Universitaria s/n Madrid 28040 34913941454 FAX: 34913941691 [email protected] Raj Razdan CEO Organix, Inc. 240 Salem Street Woburn, MA 01801 781-932-4142 FAX: 781-333-6695 [email protected] Patricia Reggio Chemistry and Biochemistry Kennesaw State University 1000 Chastain Rd. MB #1203 Kennesaw, GA 30144 770-423-6170 FAX: 770-423-6744 [email protected] Andrew Rice Pain Research (Anaesthetics) Imperial College Chelsea and Westminster Hospital 369 Fulham Road London HP16 9JL 00442087468156 FAX: 00442082375109 [email protected]

Art Riegel Cellular Neurobiology Branch NIH/National Institute on Drug Abuse 5500 Nathan Shock Drive Building C, Room 437 Balitmore, MD 21224 410-550-6565 ext.142 [email protected] Neta Rimmerman Psychology Brown University 89 Waterman Street Providence, RI 02912 401-863-2605 [email protected] Murielle Rinaldi-Carmona Exploratory Research Sanofi-Synthelabo Recherche 371 rue du Pr Blayac Montpellier Cedex 04 34184 33467106383 FAX: 33499775346 [email protected] Lianne Robinson Biomedical Sciences University of Aberdeen Institute of Medical Science Foresterhill Aberdeen AB25 2ZD 01224555775 [email protected] Philip Robson Medical Director GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected]

Elizabeth Rogers Psychology University of Reading Earley Gate Whiteknights Reading RG6 6AH 01183785539 [email protected] Julian Romero Laboratorio De Apoyo A La Investigacion Fundacion Hospital Alcorcon C/ Budapest 1 Alcorcon 28922 34916219846 [email protected] Ruth Ross Biomedical Sciences University of Aberdeen Institute of Medical Sciences Foresterhill Aberdeen AB10 6NQ 01224555705 [email protected] Michael Roth Medicine David Geffen School of Medicine/UCLA Center for Health Sciences, 37-131 Los Angeles, CA 90095-1690 310-206-7389 FAX: 310-267-2020 [email protected] Tiziana Rubino DBSF, Pharmacology Section University of Insubria via A. da Giussano 10 Busto Arsizio (VA) 21052 390331339416 FAX: 300331339459 [email protected]

Maione Sabatino Department of Experimental Medicine Second University of Naples via Costantinopoli, 16 Naples 80132 00390815667650 FAX: 00390815667503 [email protected] Devi Rani Sagar Institute of Neuroscience University of Nottingham E-Floor, Medical School Queen's Medical Centre Nottingham NG7 2UH 44115924992435779 FAX: 441159709259 [email protected] Onintza Sagredo Biochemistry, Faculty of Medicine Complutense University Ciudad Universitaria s/n Madrid 28040 34913941450 FAX: 34913941691 [email protected] Mariaelvina Sala Pharmacology, Chemotherapy and Medical Toxicology University of Milan via Vanvitelli 32 Milan 20135 390250317042 FAX: 390250317036 [email protected] Julia Sampson Pharmacology GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected]

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Cristina Sanchez Biochemistry and Molecular Biology I Complutense University School of Biology Avenida Complutense s/n Madrid 28040 34913944668 FAX: 34913944672 [email protected] María Gracia Sánchez Alonso Biochemistry and Molecular Biology School of Medicine University of Alcala Crta. Madrid-Barcelona Km:33,6 Alcala de Henares 28871 918855141 [email protected] Ana María Sánchez García Biochemistry and Molecular Biology School of Medicine University of Alcala Crta. Madrid-Barcelona Km:33,6 Alcala de Henares 28871 918855141 [email protected] Carmela Saturnino Scienze Farmaceutiche - Facoltà di Farmacia Università degli Studi di Salerno via Ponte don Melillo Fisciano (Salerno) 84084 00390899628272819 FAX: 0039089962828 [email protected] Juha Savinainen Department of Physiology University of Kuopio Savilahdentie 9 Kuopio 70211 35817163092 [email protected]

Jason B. Schechter Pharmacology University of Arizona 1501 N. Campbell Ave. Tucson, AZ 85724 520-626-2188 [email protected] Aniello Schiano Moriello ICB, CNR Via Campi Flegrei,34 Pozzuoli, Napoli 80078 0818675191 FAX: 0818041770 [email protected] Eberhard Schlicker Department of Pharmacology University of Bonn Reuterstr. 2b 53113 Bonn 53113 49228735414 FAX: 49228735404 [email protected] Herbert Schuel Anatomy and Cell Biology University at Buffalo, SUNY 206 Farber Hall Buffalo, NY 14214 716-829-3578 FAX: 716-829-2911 [email protected] Paul Schweitzer Neuropharmacology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 858-784-7258 FAX: 858-784-7393 [email protected]

Sergio Seibel Pathology - LIM-01 School of Medicine University of Sao Paulo Rua Teodoro Sampaio, 352 cj 152 Sao Paulo 05406-000 00551130821319 FAX: 00551130821319 [email protected] Herbert Seltzman Organic and Medicinal Chemistry RTI International 3040 Cornwallis Road Research Triangle Park, NC 27709 919-541-6690 FAX: 919-541-8868 [email protected] Joong-Youn Shim JLC Biomed. Biotech. Research Inst. North Carolina Central University 700 George Street Durham, NC 27707 919-530-7015 FAX: 919-530-7998 [email protected] Amruthesh Shivachar Pharmaceutical Sciences Texas Southern University 3100 Cleburne Avenue Houston, TX 77062 713-313-1896 FAX: 713-313-4219 [email protected] Laura Sim-Selley Pharmacology/Toxicology Virginia Commonwealth University 1112 East Clay Street, Box 980524 Richmond, VA 23227 804-827-0464 FAX: 804-828-1532 [email protected]

Ken Soderstrom Pharmacology and Toxicology ECU Brody School of Med 600 Moye Blvd Greenville, NC 27834 252-744-2742 FAX: 252-744-3203 [email protected] Nadia Solowij Department of Psychology University of Wollongong Northfields Avenue Wollongong NSW 2522 61242213732 [email protected] William Sones Biosciences University of Hertfordshire College Lane Hatfield AL10 9AB 01707283328 [email protected] Zhao-Hui Song Pharmacology University of Louisville School of Medicine Louisville, KY 40292 502-852-5160 [email protected] Guadalupe Soria Neuropharmacology Universitat Pompeu Fabra Dr Aiguader 80 Barcelona 08003 34935422868 FAX: 34935422802 [email protected]

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Audra Stinchcomb College of Pharmacy University of Kentucky 900 Rose Street Lexington, KY 40536-0082 859-323-6192 [email protected] Colin Stott Research and Development GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected] Takayuki Sugiura Faculty of Pharmaceutical Sciences Teikyo University Mejiro 4-6-5 Tokyo 171-0031 [email protected] Bela Szabo Pharmacology University of Freiburg Albertstrasse 25 Freiburg 79104 497612035312 FAX: 497612035318 [email protected] Anna-Maria Szczesniak Pharmacology/Neuroscience Dalhousie University Sir Charles Tupper Medical Bldg. 5850 College Street Halifax B3H 1X5 9024941287 [email protected]

Sergio Tanganelli Clinical and Experimental Medicine Section of Pharmacology University of Ferrara Via Fossato di Mortara 17-19 Ferrara 44100 00390532291212 FAX: 00390532291205 [email protected] Donald Tashkin Medicine David Geffen School of Medicine at UCLA 10833 Le Conte Avenue Los Angeles, CA 90095-1690 310-825-3163 FAX: 312-206-5088 [email protected] David Taylor Pharmaceutical Biology and Pharmacology/Faculty of Pharmacy Monash University 381 Royal Parade Parkville 3052 61399039568 FAX: 61399039638 [email protected] Adele Thomas Biomedical Sciences University of Aberdeen Institute of Medical Sciences Foresterhill Aberdeen AB24 3PT 441224555746 [email protected] Alicia Thompson Chemistry, Clemson University 341 Old Farrs Bridge Road Greenville, SC 29611-6623 864-656-6847 FAX: 864-656-6613 [email protected]

Wenger Tibor Human Morphology Semmelweis University, Tuzolto 58 Budapest H-1094 3612156920 FAX: 3612153064 [email protected] Gunnar Tiger Pharmacology and Clinical Neuroscience/Pharmacology Umeå University Umeå SE-901 87 46907851518 [email protected] Amanda Townson Psychology University of Reading, Earley Gate Reading RG6 6AL 441183785557 FAX: 441189316715 [email protected] Joseph Trettel Pharmacology University of Connecticut Health Center 263 Farmington Ave. Farmington, CT 06030 860-679-4902 [email protected] Anna Elisa Trovato Department of Biotechnology University of Milano-Bico Piazza della Scienza 2 Milano 20126 00390264483349 [email protected]

Kazuhito Tsuboi Department of Biochemistry Kagawa University School of Medicine Ikenobe 1750-1 Miki 761-0793 81878912104 FAX: 81878912105 [email protected] Sonia Tucci Psychology University of Reading Whiteknights Earley Gate, Harry Pitt Building Reading RG6 6AL 441183785539 [email protected] Natsuo Ueda Biochemistry Kagawa University School of Medicine 1750-1 Ikenobe Miki, Kagawa 761-0793 81878912102 FAX: 81878912105 [email protected] Paolo Urbani Dipartimento di Scienze Farmaceutiche Università degli Studi di Salerno via Ponte Don Melillo Fisciano (SA) 84084 39089962827 [email protected] Angelo Vaccani DBSF, Pharmacology University of Insubria Via A da Giussano 10 Busto Arsizio, Varese 21052 390331339425 FAX: 390331339459 [email protected]

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Marta Valenti Endocannabinoid Research Group Consiglio Nazionale delle Ricerche Via Campi Flegrei, 34 Pozzuoli, Napoli 80078 00393475891406 [email protected] Mario Van der Stelt Instituto di Chimica Biomolecolare Consiglio Nazionale delle Ricerche Via Campi Flegrei 34 Pozzuoli 80078 39081675193 [email protected] Marja Van Sickle Physiology and Biophysics University of Calgary 3330 Hospital Dr. N.W. Calgary T2N 4N1 4032203361 [email protected] Séverine Vandevoorde MedicinalChemistry Université de Louvain Mounier Avenue 73 UCL-CMFA 73.40 Brussels 1200 3227647345 FAX: 3227647363 [email protected] Stephen Varvel Pharmacology and Toxicology Virginia Commonwealth University 410 North 12th Street Richmond, VA 23298-0613 804-828-7264 [email protected]

Katerina Venderova Department of Immunopharmacology Academy of Sciences of the Czech Republic Videnska Praha 4 140 00 00420606560119 [email protected] Daniela Giulia Viganò DBSF, Pharmacology Section University of Insubria Via A. da Giussano 10 Busto Arsizio (VA) 21052 390331339410 FAX: 390331339459 [email protected] Laura Vitiello Biologia e Patologia Cellulare e Molecolare Università degli Studi di Napoli -Federico II Via S. Pansini 5 Napoli 80131 390817463059 FAX: 390817463252 [email protected] J Michael Walker Department of Psychology Brown University 89 Waterman Street Providence, RI 02912 401-863-2048 FAX: 401-863-1300 [email protected] Melisa Wallace Ernest Gallo Clinic and Research Center UC, San Francisco 5858 Horton Ave. Suite 200 Emeryville, CA 94608 510-985-3960 [email protected]

Gregg Ward JLC Biomed. Biotech. Research Institute North Carolina Central University 700 George Street Durham, NC 27707 919-530-7029 FAX: 919-530-7760 [email protected] David Watson CEO, HortaPharm BV Schinkelhavenkade 6 Amsterdam 1075 VS 310206185591 FAX: 310206185726 [email protected] Kerry Wease Pharmacology GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected] Sandra Welch Pharmacology and Toxicology Virginia Commonwealth University Box 980613 Richmond, VA 23298-0613 804-828-8424 FAX: 804-828-2117 [email protected] Brian Anthony Whittle Scientific Director GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected]

Jenny Wiley Pharmacology and Toxicology Virginia Commonwealth University 410 North 12th Street, Box 980613 Richmond, VA 23298-0613 804-828-2067 FAX: 804-828-2117 [email protected] Jonathan Wilkinson Pharmacognosy London School of Pharmacy 29-39 Brunswick Square London WC1N 1AX 4477709290846 [email protected] Elizabeth Williamson Centre for Pharmacognosy The School of Pharmacy University of London 29/39 Brunswick Square London WC1N 1AX 442077535841 FAX: 442077535909 [email protected] Susanne Wolf Neuronal Stem Cells Max-Dellbrück-Center for Molecular Medicine Robert-Rössle-Str. 10 Bldg. 31.1 Berlin 13125 493049063271 [email protected] David Woodward Biological Sciences Allergan 2525 Dupont Drive Irvine, CA 92623-9534 714-246-5490 FAX: 714-246-5578 [email protected]

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Stephen Wright Research and Development Director GW Pharmaceuticals plc Porton Down Science Park Salisbury SP4 0JQ 4401980557000 FAX: 4401980557111 [email protected] Karen Wright Pharmacy and Pharmacology University of Bath Claverton Down Bath BA2 7AY 441225384435 [email protected] Ozgur Yesilyurt Medical Pharmacology Gulhane Military Medical Academy Etlik, Ankara 06018 903123044765 FAX: 903123042150 [email protected] Elena Zarini Pharmacology Sanofi-Synthelabo SpA Via GB Piranesi 38 Milan 20137 00390273942414 FAX: 00390273942453 [email protected] Rundong Zhang Pharmacology and Toxicology University of Louisville 103 Nob Hill Lane #8 Louisville, KY 40206 502-852-2404 FAX: 502-852-7868 [email protected]