INCREASING THE EFFICIENCY OF PHARMACEUTICAL RESEARCH THROUGH DATA INTEGRATION Dr. Roland Bauer 12-15.Oct. 2014 ICIC 2014 Heidelberg Project Manager Content Integration & Development Elsevier Information Systems GmbH, Frankfurt [email protected]Matthew Clark Ph.D. Consultant, Life Science Services Elsevier Inc. Philadelphia, PA [email protected]
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ICIC 2014 Increasing the efficiency of pharmaceutical research through data integration
The pressures of pharmaceutical research and development demand increasing efficiency from scientists. High-quality decisions must be made faster and encompass all available information. At the same time there is a growing desire to better utilize the multi-billion dollar research investment recorded in laboratory notebooks and bioassay databases. Key values for data integration in a data exploration environment include gathering data from disparate E-notebooks and bioassay databases into a single searchable “virtual” system and increased discoverability by accessing data through a system designed for exploration. Key benefits are better chemistry decisions through easier access to broader data and reduced time for preparing patent filings. The ability to interlink in-house and reported assay data with in-house and published chemistry provides a data-rich environment for developing insights and predictive models. We will discuss our experience with integrating information from journals, patents, bio-assay databases, and E-lab notebooks to address these needs.
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INCREASING THE EFFICIENCY OF PHARMACEUTICAL RESEARCH THROUGH DATA INTEGRATION
Dr. Roland Bauer
12-15.Oct. 2014 ICIC 2014 Heidelberg
Project Manager Content Integration & Development Elsevier Information Systems GmbH, Frankfurt [email protected]
Matthew Clark Ph.D. Consultant, Life Science Services Elsevier Inc. Philadelphia, PA [email protected]
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ABOUT ME:
- “Babes –Bolyai” University, Cluj-Napoca,
Romania
- Max-Planck-Institute for Polymer Research,
Mainz, Germany
- Elsevier
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Introduction & Setting the Stage
Why?
Content Integration : The Reaxys Case
Integration Process Project Overview
AGENDA
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INTRODUCTION & SETTING THE STAGE: THE DRUG DISCOVERY INFORMATION LANDSCAPE
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INTRODUCTION & SETTING THE STAGE: TENDENCIES IN THE DRUG DISCOVERY INFORMATION LANDSCAPE
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INTRODUCTION & SETTING THE STAGE: TENDENCIES IN THE DRUG DISCOVERY INFORMATION LANDSCAPE
WHY?
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ISSUE: CHEMICAL INFORMATION ACCESS IS FRAGMENTED
• End users must learn many
interfaces
• Different data sources
have different
capabilities for searching
• Scientists may not search all
appropriate data sources
Licensed
Database
Licensed
Database
Catalog
Catalog
E-Notebook
E-Notebook References/
Full Text
INTEGRATION OF DATA PROVIDES BETTER ANSWERS
Searching multiple sources with one search via a single
interface increases efficiency
Harmonized indexing allows asking similar question
among all sources
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Easier
Access Enhanced
usage
Better
value for
investment
Better
decisions
Faster
progress
CONTENT INTEGRATION : THE REAXYS CASE
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THE REAXYS DATABASE: CONTAINS INTEGRATED PUBLISHED CHEMISTRY DATA
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THE REAXYS DATABASE: …ALONG WITH EXPANDED BIBLIOGRAPHICAL INFORMATION
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THE REAXYS TREE : BROWSE CONTENT BY ONTOLOGY
TWO APPROACHES TOWARDS INTEGRATED CONTENT
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Analysis system
End-User
Central
Storage
FEDERATED MODEL WAREHOUSE MODEL
TWO APPROACHES TOWARDS INTEGRATED CONTENT
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FEDERATED MODEL WAREHOUSE MODEL
Pros: - Easy scalability in case of new
data sources - Delivery of short term „wins“
- Maintenance costs
Cons: - Lack of normalization and
harmonized indexing
- Performance and availability dependent on the source systems
Pros: - High data quality trough
normalization
- Unified Queries and Filters applicable
Cons: - Long implementation times &
higher starting costs
- Expensive and difficult to accommodate changes in data types
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REAXYS EXTERNAL CONTENT INTEGRATION
Database
End-User
ELN 1
ELN 2
CUSTOM IN HOUSE
REACTIONS SOURCE
Indexed Storage
RX CONTENT EXTERNAL CONTENT
Customer Hosted
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REAXYS EXTERNAL CONTENT INTEGRATION: IN HOUSE SCENARIO