IBD: East Meets West...15.10 Coffee break with poster session 15.40 Presentation of Poster Prizes G . Rogler, Zurich Session VIII Biologicals and beyond hair: C J .-M . Qian, Bejing;

Preliminary Program

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Application for CME credits submitted

General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-Mail: [email protected]

Falk Symposium 198

IBD: East Meets West

September 11 – 12, 2015InterContinental ShenzhenShenzhen, P. R. China



Telephone: +49(0)761/1514-0 Telefax: +49(0)761/1514-359 E-Mail: [email protected] www.falkfoundation.org

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112434_Falk_China_Symp198_PremProg_UG.indd 1 03.02.15 13:33

3

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

List of Speakers, Moderators and Scientific Organizers . . . . . . . . . . . . . . . . . . . . . . . . 11

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

CME credits for the Falk Symposium 198 have been applied for at the European Union of Medical Specialists (UEMS) – European Board of Gastroenterology (EBG) . The number of credits awarded will be printed in the final program .

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Preface

Dear Colleagues,

The 198th Falk Symposium in Shezhen, P .R . China will cover topics of recent development in inflammatory bowel disease . Unlike other FALK meetings in the past this meeting is unique in that it includes joint faculties from the Asia-Pacific and the European/American regions . Each session will be chaired by experts from both regions . The faculty represents a balanced panel of outstanding researchers and clinicians .

IBD is a global disease . In the past decade, a rapid increase in the incidence of IBD has been reported in several countries in the Asia-Pacific area . Genetic and microbial factors appear to differ between European and non-European populations . Nevertheless the clinical characteristics of the diseases, healthcare implications and medical needs of our patients are similar . Therefore, it is important to exchange experience and knowledge and to learn from each other . The organizers believe that this meeting with its unique concept and outstanding faculty will serve as a platform to exchange ideas and foster new collaborations and connections between the East and the West in order to advance our understanding and knowledge of IBD .

Michael A . Kamm Siew C . Ng Gerhard Rogler

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Falk Symposium 198



Registration:Thursday, September 10, 201516 .00 – 21 .00 hat the congress office

Scientific Organization:M . A . Kamm, Melbourne (Australia)S . C . Ng, Hong Kong (Hong Kong)G . Rogler, Zurich (Switzerland)

Congress Venue:InterContinental Shenzhen9009 Shennan RoadShenzhen, 518053P . R . China

Information:Prof . Dr . Dr . Gerhard RoglerUniversitätsspital ZürichKlinik für Gastroenterologie& HepatologieRämistrasse 1008091 ZürichSwitzerlandTelephone: +41 (0)44/255-9477Telefax: +41 (0)44/255-9497E-Mail: gerhard .rogler@usz .ch

Official Language:English . Simultaneous translation into Chinese .

Call for Posters:A poster session will take place .For details see page 10 .

Publication Date of the Final Program: September 2015

The final program will be available on the homepage www .falkfoundation .org one week before .

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Friday, September 11, 2015

8.00 Opening remarks G . Rogler, Zurich

Session I Genetic risk factors in IBD: Do they play the same role in East and West?

Chair: R . H . Duerr, Pittsburgh; S . C . Ng, Hong Kong

8.10 Risk genes in Europe and America: S . Schreiber, What are the most important pathways affected? Kiel

8.35 Risk genes in the Asia/Pacific area: K .-C . Wu, What are the most important pathways affected? Xi‘an

9.00 The “promise of epigenetics”: Has it delivered new J . Cho, insights? New York

9.25 State-of-the-Art Lecture: R . S . Blumberg, Environment and genes: What is the interaction? Boston

9.50 Coffee break with poster session

Session II IBD: Environmental contributions to disease onset in East and West?

Chair: R . Gearry, Christchurch; R . B . Sartor, Chapel Hill

10.20 What impacts the epithelial barrier? J . Wehkamp, Tubingen

10.45 Factors causing cell stress: Do they come from the A . Kaser, environment? Cambridge

11.10 What role does a dysfunction of autophagy play for V . Deretic, IBD onset Albuquerque

11.35 The hygiene hypothesis: Is the evidence the same all R . Leong, over the world? Sydney

12.00 Mucosal bacteria and their impact for IBD L . Zhao, Shanghai

12.30 Lunch break with poster session

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Friday, September 11, 2015 Session III

The mucosal innate immune system: What does it teach us for the development of new therapy

Chair: R . S . Blumberg, Boston; M . A . Kamm, Melbourne

14.00 Endothelial cell – immune cell interaction S . Danese, Milan

14.25 Bacterial translocation across the barrier and D . Haller, subsequent reactions Munich

14.50 Macrophages, lymphocytes or dendritic cells: S . Knight, Which are the important players? London

15.15 Innate lymphoid cells: Future therapy targets in IBD? A . Diefenbach, Mainz


Session IV Environmental triggers for disease onset: Can we avoid them?

Chair: G . Rogler, Zurich; J . J . Y . Sung, Hong Kong

16.00 Psychological stress and depression: C . N . Bernstein, Risk factors for IBD? Winnipeg

16.25 An “inflammatory microbiota”: Defining the role in IBD? M . Morrison, Brisbane

16.50 Smoking and diet: Impact on disease course? J . Cosnes, Paris

17.25 High altitude journey, flights and hypoxia: S . Vavricka, Any role for disease flares? Zurich

17.50 State-of-the-Art Lecture: R . Gearry, IBD and environment: Are there differences between Christchurch East and West?

18.20 End of afternoon session

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Saturday, September 12, 2015 Session V

Treatment decisions: Common markers in East and West?

Chair: P . L . Lakatos, Budapest; Q . Ouyang, Chengdu

8.00 ASCA, ANCA, ALCA and many more: Are they useful? Z . Liu, Shanghai

8.25 Risk factors for complicated disease: A . Dignass, Do we really know any? Frankfurt

8.50 Calprotectin or Lactoferrin: Do they help? E . K . Wright, Melbourne

9.15 Iron deficiency, zinc, magnesium, vitamin deficiencies: A . Ananthakrishnan, Substitute or not substitute? Boston


Session VI The basics of IBD therapy

Chair: M . Chen, Guangzhou; J . Schölmerich, Frankfurt

10.10 Antibiotics for IBD therapy? R . N . Fedorak, Edmonton

10.35 5-ASA: topical, oral or both? S . B . Hanauer, Chicago

11.00 When should immunosuppression be started? A . Sharara, Beirut

11.25 Anti-TNFs: Originators and Biosmilars G . J . Mantzaris, Athens

11.50 State-of-the-Art Lecture: J . J . Y . Sung, The benefits of early and combination therapy with Hong Kong immunosuppressants: Are there any?

12.20 Lunch break with poster session

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Saturday, September 12, 2015 Session VII

New options/treatments goals for IBD therapy Chair: G . van Assche, Leuven; T . Hibi, Tokyo

13.30 New data on methotrexate H . Herfarth, Chapel Hill

13.55 “Treat to target” – lessons learnt P . L . Lakatos, Budapest

14.20 Anti-integrins in UC and CD: What is their place? B . G . Feagan, London, ON

14.45 Mucosal healing: How deep is enough? S . Ghosh, Calgary


15.40 Presentation of Poster Prizes G . Rogler, Zurich

Session VIII Biologicals and beyond

Chair: J .-M . Qian, Bejing; C . J . van der Woude, Rotterdam

15.50 Stem cell transplantation: The ASTIC trial M . Allez, Paris

16.15 The challenge of intestinal tuberculosis as a Z .-H . Ran, differential diagnosis Shanghai

16.40 Surgery or biological therapy: Cost efficacy S . P . L . Travis, Oxford

17.05 Personalising IBD therapy: The Asian Perspective S .-K . Yang, Seoul

17.30 State-of-the-Art Lecture: P .-J . Hu, The future of IBD therapy: Where do we go from here? Guangzhou

18.00 Closing remarks

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Poster SessionPosters will be exhibited on September 11-12, 2015 in the InterContinental Shenzhen . The authors will be in attendance during coffee and lunch breaks on both days .

Call for PostersPlease submit your poster abstract before April 30, 2015 . Only one-page abstracts not exceeding 300 words, written in English and saved in Microsoft Word format will be accepted .

Abstracts must be submitted via our Internet Abstract Submission System (http://www .falkfoundation .org/poster) where further information regarding the submission format and the submission process is available .

The abstracts will be selected by the scientific organizers, preference being given to those thematically related to one of the sessions of the program .

The accepted abstracts will be printed and distributed to the participants of the congress together with the documents of the meeting .

The authors will receive notification about acceptance and further instructions in May 2015.

Contact address for further information on the poster session:

Falk Foundation e . V . Congress Department Leinenweberstr . 5 79108 Freiburg (Germany) Telephone: +49 (0)761/1514-0 Telefax: +49 (0)761/1514-359

Web address for submitting poster abstracts: http://www .falkfoundation .org/poster

For the first author of an accepted poster, expenses for accommodation (September 10-13, 2015) and fees for the scientific program and evening activities will be covered during the Falk Symposium 198 . Travel expenses will not be covered.

Poster PrizesThree prizes will be awarded for the best presentations . Prize winners will be presented with a certificate and prize money for € 1,500, € 1,000 and € 500 respectively . Travel expenses will be covered additionally for the first author of prize winning posters .

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List of Speakers, Moderators and Scientific Organizers

Prof. Dr. Matthieu AllezService de GastroentérologieHôpital Saint-Louis1 Avenue Claude Vellefaux75010 ParisFrancematthieu .allez@gmail .com

Ashwin Ananthakrishnan, M.D.Division of GastroenterologyMassachusetts General Hospital165 Cambridge StreetBoston, MA 02114USAaananthakrishnan@mgh .harvard .edu

Prof. Dr. Gert van AsscheGastroentérologieUniversity ZiekenhuisGasthuisbergHerestraat 493000 LeuvenBelgiumgert .vanassche@uz .kuleuven .ac .be

Dr. Charles N. BernsteinDepartment of GastroenterologyUniversity of Manitoba804 F-175 McDermot AvenueWinnipeg MB R3E 3P4Canadacharles .bernstein@med .umanitoba .ca

Richard S. Blumberg, M.D.Professor of MedicineGI DivisionHarvard Medical SchoolBrigham and Women‘s Hospital75 Francis StreetBoston MA 02115USArblumberg@partners .org

Dr. Minhu ChenDivision of Gastroenterology and HepatologyDepartment of MedicineThe First University HospitalSun Yat-sen University58 Zhongshan Road IIGuangzhouP . R . Chinachenminhu@vip .163 .com

Judy Cho, M.D.Dept . of Genetics andGenomic SciencesIchan School of MedicineThe Mount Sinai Medical CenterOne Gustav L . Levy Place,Box 1498New York NY 10029-6574USAjudy .cho@mssm .edu

Prof. Dr. Jacques CosnesService de Gastroentérologieand NutritionHôpital Saint Antoine 184, Rue du Faubourg St .-Antoine75012 ParisFrancejacques .cosnes@sat .aphp .fr

Dr. Silvio DaneseIstituto Clinico Humanitas IRCCSIRCCS in GastroenterologyVia Manzoni, 5620089 RozzanoItalysdanese@hotmail .com

Vojo Deretic, M.D.Professor of Molecular GeneticsDept . of Molecular Geneticsand MicrobiologyUniversity of New Mexico915 Camino de Salud, NEAlbuquerque NM 87131USAvderetic@salud .unm .edu

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Prof. Dr. Andreas Diefenbach Institut für Medizinische Mikrobiologieund HygieneUniversitätsmedizin MainzObere Zahlbacher Str . 67 D 55131 Mainz Germanyandreas .diefenbach@uni-mainz .de

Prof. Dr. Axel DignassMedizinische Klinik IAGAPLESIONMarkus KrankenhausWilhelm-Epstein-Str . 460431 FrankfurtGermanyaxel .dignass@fdk .info

Richard H. Duerr, M.D.Professor of MedicineInflammatory Bowel Disease CenterBiomedical Science TowerUniversity of Pittsburgh200 Lothrop StreetPittsburgh PA 15213USAduerr@pitt .edu

Dr. Brian G. FeaganRobarts Research InstituteLCTRGUniversity of Western Ontario100 Perth DriveLondon ON N6A 5K8Canadabfeagan@robarts .ca

Prof. Dr. Richard N. FedorakDivision of GastroenterologyUniversity of Alberta2-14A Zeidler BuildingEdmonton AB T6G 2X8Canadarichard .fedorak@ualberta .ca

Dr. Richard GearryAssoc . ProfessorDept . of MedicineUniversity of Otago, ChristchurchPO Box 4345Christchurch 8140New Zealandrichard .gearry@cdhb .health .nz

Subrata Ghosh, M.D.Professor of Medicine,Microbiology and ImmunologyUniversity of CalgaryFoothills HospitalDepartment of Gastroenterology1403 29th St . NWCalgary AB T2N 2T9Canadasubrata .ghosh@albertahealthservices .ca

Prof. Dr. Dirk HallerLehrstuhl für Ernährung und ImmunologieWissenschaftszentrum WeihenstephanTechnische Universität MünchenGregor-Mendel-Str . 285350 Freising-WeihenstephanGermanydirk .haller@tum .de

Stephen B. Hanauer, M.D.Professor of MedicineUniversity of ChicagoDepartment of MedicineGastroenterology Section5841 S . Maryland Ave .Chicago IL 60637-1463USAshanauer@medicine .bsd .uchicago .edu

Hans Herfarth, M.D.Professor of MedicineDivision of Gastroenterology and HepatologyDepartment of MedicineUniversity of North Carolina4151 Bioinformatics Bldg .130 Mason Farm RoadChapel Hill NC 27599-7080USAhherf@med .unc .edu

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Prof. Dr. Toshifumi HibiCenter for Advanced IBD Research and TreatmentKitasato Institute HospitalKitasato University5-9-1 ShirokaneMainato-ku, Tokyo 108-8642Japanthibi@insti .kitasato-u .ac .jp

Prof. Dr. Pin-Jin HuDepartment of GastroenterologyThe Sixth Affiliated HospitalSun Yat Sen University26 Yuancunerheng RoadGuangzhou 510655P . R . Chinapjhumd@vip .163 .com

Prof. Dr. Michael A. KammSt . Vincent‘s HospitalUniversity Dept . of MedicineDepartment of GastroenterologyVictoria ParadeFitzroy VI 3065MelbourneAustraliakamm@medstv .unimelb .edu .au

Prof. Dr. Arthur KaserDivision of Gastroenterology& HepatologyUniversity of CambridgeAddenbrooke‘s HospitalHills RoadCambridge CB2 0QQGreat Britainak729@cam .ac .uk

Prof. Dr. Stella KnightDepartment of MedicineImperial College LondonNorthwick Park andSt . Marks’ CampusWatford Rd .Harrow HA1 3UJGreat Britains .knight@imperial .ac .uk

Prof. Dr. Peter L. LakatosSemmelweis UniversityMedical SchoolI Department of MedicineKoranyi u . 2/a1083 BudapestHungarylakatos .peter_laszlo@ med .semmelweis-univ .hu

Prof. Dr. Rupert LeongGastroenterology and Liver ServicesConcord HospitalHospital RdSydney, NSW 2139Australiarupert .leong@sswahs .nsw .gov .au

Prof. Dr. Zhanju LiuDept . of GastroenterologyShanghai Tenth People‘s HospitalTongji UniversityNo 301 Middle Yanchang RdShanghai 200072P . R . Chinaliuzhanju88@126 .com

Prof. Dr. Gerassimos J. MantzarisDept . of GastroenterologyEvangelismos Hospital45-47, Ypsilantou street, Kolonaki106 76 AthenGreecegjmantzaris@gmail .com

Prof. Dr. Mark MorrisonTranslational Research InstituteUniversity of QueenslandDiamantina Institute37 Kent StreetWooloongabba QLD 4102Australiam .morrison1@uq .edu .au

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Prof. Dr. Siew C. NgDepartment of Medicine and TherapeuticsInstitute of Digestive DiseaseChinese University of Hong KongHong KongHong Kongsiewchienng@cuhk .edu .hk

Prof. Dr. Qin OuyangGI DepartmentWest China HospitalSichuan University37#, Guoxue Street610041 ChengduP . R . Chinaqin .ouyang@163 .com

Prof. Dr. Jia-Ming QianBeijing UnionMedical College HospitalDepartment of Gastroenterology1 Shuaifu Garden, Dongcheng100730 BeijingP . R . Chinagjiaming1957@aliyun .com

Prof. Dr. Zhi-Hua RanRenji HospitalShanghai Jiaotong UniversityDepartment of Gastroenterology160 Pu Jian Rd ., Pudong Distr .200001 ShanghaiP . R . Chinazhihuaran@vip .163 .com

Prof. Dr. Dr. Gerhard RoglerUniversitätsspital ZürichKlinik für Gastroenterologie& HepatologieRämistrasse 1008091 ZürichSwitzerlandgerhard .rogler@usz .ch

R. Balfour Sartor, M.D.Professor of Medicine,Microbiology and ImmunologyUniversity of North CarolinaSchool of MedicineGastroenterology & Hepatology111 Mason Farm RoadChapel Hill NC 27599-7032USArbs@med .unc .edu

Prof. Dr. Jürgen SchölmerichKlinikum der Johann WolfgangGoethe-Universität FrankfurtTheodor-Stern-Kai 760596 FrankfurtGermanyaed@kgu .de

Prof. Dr. Stefan SchreiberInnere Medizin IUniversitätsklinikumSchleswig-Holstein, Campus KielArnold-Heller-Straße 3 (Haus 6)24105 KielGermanys .schreiber@mucosa .de

Prof. Dr. Ala ShararaDivision of GastroenterologyDepartment of Internal MedicineAmerican University of Beirut Medical CenterPO Box 11-0236, Riad El Solh 11072020 BeirutLebanonala .sharara@aub .edu .lb

Prof. Dr. Joseph J. Y. SungDepartment of Medicine& TherapeuticsThe Chinese Universityof Hong KongShatin, New TerritoriesHong KongHong Kongjoesung@cuhk .edu .hk

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Dr. Simon P. L. TravisTranslational Gastroenterology UnitOxford University Hospitals NHS TrustHeadley Way HeadingtonOxford OX3 9DUGreat Britain simon .travis@ndm .ox .ac .uk

PD Dr. Stephan VavrickaAbt . für Gastroenterologie& HepatologieStadtspital TriemliBirmensdorferstr . 4978063 ZürichSwitzerlandstephan .vavricka@triemli .stzh .ch

Prof. Dr. Jan WehkampAbteilung Innere Medizin IHepatologie, Gastroenterologie, InfektiologieUniversitätsklinikum TübingenOtfried-Müller-Str . 1072076 TübingenGermanyjan .wehkamp@med .uni-tuebingen .de

Prof. Dr. Emily K. WrightDepartment of GastroenterologySt Vincent‘s Hospital41 Victoria Parade Fitzroy 3065MelbourneVictoria, Australiaemily .wright@svha .org .au

Prof. Dr. C. Janneke van der WoudeAfd . GastroenterologieErasmus Medical Center’s-Gravendijkwal 2303015 CE RotterdamThe Netherlandsc .vanderwoude@erasmusmc .nl

Dr. Kai-Chun WuDepartment of GastroenterologyXijing Hospital15 Western Changle Road710032 Xi‘an, Shanxi ProvinceP . R . Chinakaicwu@fmmu .edu .cn

Dr. Suk-Kyun YangDepartment of GastroenterologyUniversity of Ulsan College of MedicineAsan Medical CenterSeoulSouth Koreasky@amc .seoul .kr

Prof. Dr. Liping ZhaoSchool of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityBiology Building No . 800 Dongchuan RoadMinhang CampusShanghai 200240P . R . Chinalpzhao@sjtu .edu .cn

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General InformationPrior to the opening of the congress

Falk Foundation e . V . Telephone: +49 (0)761/1514-0Congress Department Telefax: +49 (0)761/1514-359Leinenweberstr . 5 E-Mail: symposia@falkfoundation .de79108 Freiburg (Germany)

Congress OfficeDuring the Falk Symposium 198

InterContinental Shenzhen9009 Shennan RoadShenzhen, 518053P . R . China

Congress office on site Telephone: +49 (0)175/7795327

Opening Hours:Thursday, September 10 2015 16 .00 – 21 .00 hFriday, September 11, 2015 7 .00 – 18 .30 hSaturday, September 12, 2015 7 .00 – 18 .30 h

Congress FeesScientific program of the Falk Symposium 198 € 200 .00Students and residents € 100 .00

* * *OR* * *

Day ticket € 120 .00Students and residents € 60 .00

Employees of pharmaceutical or other companies and their guestsFalk Symposium 198 € 600 .00

The congress fees include:- Welcome Evening on September 10, 2015- Refreshments during coffee breaks- Lunch on September 11 and 12, 2015- A copy of the abstract volume

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RegistrationCongress registrations must reach the Falk Foundation e . V . by June 30, 2015 at the latest .

After receipt of the registration form, each participant will be provided with an invoice/confirmation . On presentation of this confirmation at the congress office in Shenz-hen participants will receive the congress folder containing name badges, admission tickets and wabstract volume . In the case of registration cancellations, a handling fee of € 20 .00 will be deducted from the refund . All participants will receive a written confirmation of attendance at the meeting .

Admission to Scientific EventsFor admission to scientific events your name badge should be clearly visible .

Congress ReportThe official congress report of the Falk Symposium 198 “IBD: East meets West” will be published in English in the first half of 2016 by Karger, Switzerland . Orders for this book at a reduced subscription price of € 35 .00 can be placed at the Congress Office during the congress in Shenzhen .

AirportShenzhen Airport: http://eng .szairport .com/Hong Kong International Airport: http://www .hongkongairport .com/eng/index .html

Preliminary Program

VP

198e

1-1

1/20

14/1

.20

0 St

ü

Application for CME credits submitted



Congress DepartmentTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-Mail: [email protected]

Falk Symposium 198





Telephone: +49(0)761/1514-0 Telefax: +49(0)761/1514-359 E-Mail: [email protected] www.falkfoundation.org

Falk

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un

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Plea

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or le

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Paym

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112434_Falk_China_Symp198_PremProg_UG.indd 1 03.02.15 13:33

IBD: East Meets West...15.10 Coffee break with poster session 15.40 Presentation of Poster Prizes G . Rogler, Zurich Session VIII Biologicals and beyond hair: C J .-M . Qian, Bejing;

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