Hypotension Focus: “It’s not ACS or HF, but it will be on the PANRE” Andrea Applegate, PA-C Question #1 Which of the following “pains” is associated with orthostatic hypotension? A. “toe box” pain B. “coat hanger” pain C. “hat band” pain D. “saddle” pain Question #2 If a patient complains of nausea and dizziness 5 times in the past year, which they believe is associated with “low pressure”, they are ___ A. Class I B. Class II C. Class III D. Faking it
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Hypotension Focus: “It’s not ACS or HF, but it will be on ... · Medications to consider decreasing or stopping: Diuretics, sympatholytics, vasodilators, antihypertensives, antidepressants,
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Hypotension Focus: “It’s not ACS or HF, but it will be on
the PANRE”Andrea Applegate, PA-C
Question #1
Which of the following “pains” is associated with orthostatic hypotension?
A. “toe box” pain
B. “coat hanger” pain
C. “hat band” pain
D. “saddle” pain
Question #2
If a patient complains of nausea and dizziness 5 times in the past year, which they believe is associated with “low pressure”, they are ___
A. Class I
B. Class II
C. Class III
D. Faking it
Question #3VA ECMO does which of the following?
A. Oxygenates blood while allowing the heart to pump naturally
B. Contains ghosts after they are lassoed by a Proton Pack.
C. Circulates blood during routine open heart surgery.
D. Oxygenates and circulates the blood.
Hypotension Focus: Orthostatic Hypotension
Orthostatic intoleranceOrthostatic hypotension (primary vs secondary)
Structural (neurogenic): chronic autonomic failure. Multiple system atrophy, Parkinson’s disease. Can also be secondary to diabetes, amyloidosis, or advanced renal failure.
Functional (non-neurogenic): treatment with vasodilators, TCA, chemo, diuretics, blood volume loss, heart failure with chronotropic or inotropic changes.
Neutrally mediated (reflex) syncope
Postural tachycardia syndrome
Blood pressure regulation
Clinical PresentationNormal response to standing:
Pooling of blood in lower extremities and splanchnic circulation (500-1000 ml)
Venous return to the heart decreases, resulting in diminished cardiac output and BP.
Compensatory reflex with nervous system increases sympathetic stimulation and decreases parasympathetic (baroreceptor reflex).
Peripheral vascular resistance is raised with SNS stimulation, increasing venous return and reversing above changes in vitals, limiting BP drop.
Exacerbated by venous pooling and dehydration; heat, fever, alcohol, urination, post-exercise, and immobilization. Nocturnal polyuria can occur due to fluid shifts, causing overnight volume loss.
Can occur after eating (postprandial hypotension) and worse in those with autonomic failure.
Etiology20% of those aged >65 were found to have postural hypotension.
Some studies associate it with vasodilators including nitrates and CCB, antidepressants, opiates, and alcohol.
Most do not have underlying neurogenic cause.
Consider adrenal insufficiency, central nervous system dysfunction, arrhythmia, spinal cord origin, myocardial ischemia, autonomic neuropathy, sepsis, hypovolemia, and acute autonomic neuropathy.
In young, usually occurs in volume depletion or chronic autonomic failure.
Criteria, updated 2011Classic: Drop in SBP 20 mmHg or DBP 10 mmHg within 3 minutes or stand or tilt.
Initial: rapid drop in SBP 40 mmHg and/or DBP of 20 mmHg within 15 seconds.
With hypertension: drop of SBP of 30 mmHg or more (higher baseline).
Delayed: reduction occurring after 3 minutes of standing, may progress up to 45 minutes.
Tilt Table TestingIndicated in high probability despite negative eval, motor impairment, and monitoring response to therapy.
Patient is supine for 5 minutes, then table is slowly elevated 60-80 degrees for three minutes.
Positive if blood pressure falls or if patient becomes symptomatic.
Evaluation
Classes of OH
TreatmentConservative Treatment:
Compression hose (30-50 mmHg) hip height.
Abdominal binding (20-30 mmHg): may increase tolerance of BP drop by 40%. Remember “the higher, the better” due to volume of venous circulation in abdomen.
Physical counter-maneuvers: avoiding sudden changes, 5 minute “dangle”, 2 L of fluid per day, avoiding hot environments, calf exercises, squats.
Head of bed height elevated 10-30 degrees
Neurogenic OH may improve with bolus water intake and eating smaller more frequent meals.
Comprehensive Geriatric Assessment (CGA)
Medications to consider decreasing or stopping: Diuretics, sympatholytics, vasodilators, antihypertensives, antidepressants, anti-parkinsonism medications.
Treatment, cont.Fludrocortisone: synthetic mineralocorticoid, expands plasma volume with sodium intake.
Midodrine: alpha-adrenoceptor agonist. Should be taken 1 hour before rising, last dose 4 hours before bed to avoid nocturnal hypertension. Half life of 3 hours.
Droxidopa: prodrug metabolized to noradrenaline. Administer during the day to avoid NOC HTN.
May result in multi-system organ failure and can become irreversible.
Types of Shock
Distributive
Hypovolemic
Obstructive
Cardiogenic
Cardiogenic ShockDecreased cardiac output and hypoperfusion despite adequate volume status.
Signs: poor UOP, tachycardia, mental status changes, cyanosis, increased respirations. May have normal BP, JVD, rales, clammy appearance.
Eventually develop systemic hypotension.
Systolic blood pressure <90 mm Hg, cardiac index <2.2 L/min/m2, and the presence of normal or elevated pulmonary capillary occlusion pressure [>15 mm Hg], or right ventricular [RV] end-diastolic pressure [RVEDP; >10 mm Hg])
Who to suspect
STEMI (chest pain, EKG changes)
Acute aortic or mitral valve insufficiency (chest pain, new murmur, pulmonary edema)
Dissection (hypertension, tearing chest and/or back pain)
Arrhythmia (abnormal EKG, syncope)
Myocardial infarction
Loss of perfusion to myocardium resulting in inability to contract. Can lead to necrosis or stunned myocardium.
“Orthostatic Hypotension: Epidemiology, Prognosis, and Treatment” Fabrizio Ricci et al. Journal of the American College of Cardiology: 66 (7):848-860. Accessed 04/30/2018.
“New Horizons in Orthostatic Hypotension” Age Ageing. 2017; 46 (2): 168-174. Medscape accessed 04/30/2018.
“Postural and Postprandial Hypotension: Approach to Management” Geriatrics and Aging 2007; 10(5):298-304. Medscape accessed 04/30/2018.
“Evaluation and Management of Orthostatic Hypotension” American Family Physician. 2011 September; 84(5):527-536. Accessed online 04/30/2018.