HYPERSENSITIVITY Iori O NORMAL immune Nhs DONT HURT the host o o o o o o it EXCESSIVE ANTIGENS o disease causing a p p p p p a normal immune response sensitized Bugs Environment excessive response hypersensitive self PROCESS x i RXN TYPES immune response triggered maintained inappropriately type l ALLERGY hard to eliminate stimulus immediate hard to STOP oncestarting antigenbinds to IgE antibodi SO hypersensitivity diseases Chronic on mast cell Debilitating Hard totreat STEPS release mediator allergen inhaled leatent RESULT ad tyfpI ANTIBODIES injected dilation antibodies bindto antigens allergen Slims 11 2 prod SM contraction oncell surface THI secrete cytokines inflam persists STEPS macrophageseat mast cell binds IgE Ab bindtocell complement activated allergen bridges IgEonmast cell surface antigens inflam occurs mast celldegranulates These happen RESULT cells die inflamharms opsonizationlphagoc t Shyt RE tAgfEainme contents OR inflammation histamine OR chemotactic factor cellular dysfunction gyrqnyile.fi temnetmsjL.mem.bprPoYfIhgf'ainiadmmetabolites phosph metabolites leukotrienes jtijp 3 im OMPfxE.actonBrs.sm cytokines Ab bindto Ag complexes WBCs PT RESPONSE 4 complexes circa te immediate responsemin TWO TYPES e get stuck vasodibras leak LOCAL 7 SM spasm skin it.ch hives Systemic IC inflammation granule contents prostag Gl diarrhea disease necrotizing vasculitis leukotrienes lung bronohoconst complexes formed in ciro late rXh hrs ANAPHYLAXIS 7 deposited in inserieral organs inflaml tissuedestruct itch hives red EX scrum sickness I Inoffeeisgernupnffeiinniect cytokines broncho constwheezin Ab made Ab Ag complex laryngeal edema local 1C list All complexes lodge in kidneyjoints small vessels Manthe complexesformed antigen inject site inflam fever pain proteinuria vomitcrampsdiarrhe