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Hypercalcemia in children and adolescent

Jan 21, 2018

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Health & Medicine

Yassin Alsaleh
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Page 1: Hypercalcemia in children and adolescent
Page 2: Hypercalcemia in children and adolescent

• 20 month old girl case of wiliam syndrome presented with vomiting and dehydration .

• Found to have hypercalcemia • ca 3.96 mmol/l . urine ca/creat ratio 4.6 high.• PO3:1.45 Vit d 55. PTH 3.6.• This is the 4th episode of hypercaclemia over last 2

months .• Patient started on IV hydration , lasix and steroid • after 48 hr, calcium reach 2.6 mmol/l steroid stopped • Ca level start to increase again reaching 3.5 mmol/l

so steroid resumed • ca level maintained below 3 .

Page 3: Hypercalcemia in children and adolescent

• Hypercalcemia is less common in children than in adults.

• It is more likely to be clinically significant in younger patients

• the aetiologies are diverse and age specific.

• Hypercalcaemia is a serious condition that can leads to end-organ damage.

Page 4: Hypercalcemia in children and adolescent

• Normal serum levels of calcium are maintained through the interplay of parathyroid, renal, and skeletal factors.

• a key part of the management is to establish the correct diagnosis promptly.

Page 5: Hypercalcemia in children and adolescent

• Iatrogenic• Phosphate Depletion• Premature infants on human

milk or standard formula• Hyperparathyroidism– Congenital parathyroid

hyperplasia– Maternal hypoparathyroidism• Inactivating mutations in

Ca2+-sensing receptor gene• – Familial hypocalciuric

hypercalcemia (familial benign hypercalcemia)

• – Neonatal severe hyperparathyroidism

• Jansen’s metaphyseal chondrodysplasia

• Hypervitaminosis D• Subcutaneous fat necrosis• Williams

syndrome/Idiopathic infantile hypercalcemia

• Other inborn metabolic disorders

– Blue diaper syndrome– Lactase deficiency– Bartter syndrome• Hypophosphatasia• IMAGe• Maternal hypercalcemia• Vitamin A intoxication

Differential diagnosis of hypercalcemia in neonates and infants (up to 2 years of age)Differential diagnosis of hypercalcemia in neonates and infants (up to 2 years of age)

Page 6: Hypercalcemia in children and adolescent

• Excessive calcium intake

• Parenteral nutrition

• Hyperparathyroidism

♦ adenoma/carcinoma

– Genetic primary

♦ autosomal dominant/récessive FHH

♦ familial

♦ MEN types I and IIa

♦ Hyperparathyroidism-Jaw tumor

– Autonomous (tertiary)

• Hypervitaminosis D

– Excessive intake

– Granulomatous diseases: cat scratch fever; sarcoidosis; tuberculosis; histoplasmosis; coccidiomycosis; leprosy; HIV

– Chronic inflammatory disorders

• Immobilization• Malignancy associated hypercalcemia– Primary bone tumors– Metastatic tumors with osteolysis– Tumors secreting PTHrP, • Hepatic disease• Hyperthyroidism• Adrenal insufficiency• Pheochromocytoma• Drugs (thiazides, lithium, systemic retinoid derivatives,)• Chronic renal failure

Differential diagnosis of hypercalcemia in neonates and infants (over 2 years of age)Differential diagnosis of hypercalcemia in neonates and infants (over 2 years of age)

Page 7: Hypercalcemia in children and adolescent

Nervous system

Behavioural changes

Headache

Hallucinations

Unsteady gait

Muscle hypotonia,

Proximal muscle

weakness/

myopathy

Seizures

Irritability/confusion

Encephalopathy, Coma

Renal systemRenal stonesnephrocalcinosis, Polyuria and polydipsiaRenal failureMusculoskeletalBone painEctopic calcificationMiscellaneousConjuctivitisBand keratopathyfailure to thriveArrhythmiacardiomyopathy

Gastrointestinal systemParalytic ileusAbdominal crampingConstipationAnorexiaNauseaVomitingPancreatitis

Page 8: Hypercalcemia in children and adolescent

• History• Symptoms suggestive of hypercalcaemia• Symptoms suggestive of malignancy• Drug history, including vitamin D therapy, • Family history of renal stone, hypercalcaemia,

parathyroidectomy, multiple endocrine neoplasia

• Examination• Assess degree of dehydration• Syndromic features• Presence of ectopic/subcutaneous calcification/rash• Generalised lymphadenopathy, organomegaly• Bone pain, fractures

Page 9: Hypercalcemia in children and adolescent

• investigations • Bone profile, PTH, urine ca.• Investigation of parents for abnormalities

of calcium homeostasis• Imaging:• Renal ultrasound scan• Skeletal survey• Parathyroid gland ultrasound scan• Parathyroid gland SestaMIBI scan

Page 10: Hypercalcemia in children and adolescent

• The management of hypercalcemia depends on the severity and cause of the elevation of serum Calcium.

Page 11: Hypercalcemia in children and adolescent

• Patients with asymptomatic or mildly symptomatic hypercalcemia (calcium <12 mg/dL [3 mmol/L])

• no initial treatment may be necessary .• medical efforts to reach a diagnosis

should be given the preference.

Page 12: Hypercalcemia in children and adolescent

• When hypercalcemia is severe (total serum calcium >14mg/dL) (3.5 mmol/L) .

• Or when there are symptoms .

Page 13: Hypercalcemia in children and adolescent

• Discontinuation of calcium supplements• Discontinue medications that

independently lead to hypercalcaemia, e.g. thiazides, vitamin D, calcitriol

• Increase the weight bearing mobility of the patient

Page 14: Hypercalcemia in children and adolescent

• low calcium formula in the infant .

• Low calcium diet in the older child.

Page 15: Hypercalcemia in children and adolescent

Treatment of underling cause

Page 16: Hypercalcemia in children and adolescent
Page 17: Hypercalcemia in children and adolescent

• Filtered calcium is principally reabsorbed in the proximal tubule and the ascending loop of Henle.

• This process is mainly passive.• whereas active resorption of calcium occurs in the

distal loop under the influence of PTH and to a lesser degree 1,25(OH)2D.

• Proximal reabsorption is inhibited by volume expansion from intravenous saline infusion, which increases delivery of sodium, calcium and water to the loop of Henle.

• administration of a loop diuretic such as furosemide then blocks transport at loop of henle

Page 18: Hypercalcemia in children and adolescent

• Initial treatment of hypercalcemia involves hydration to improve urinary calcium output.

• Isotonic sodium chloride solution is used.• MOA: to increase the glomerular filtration

rate , increasing sodium excretion increases calcium excretion.

• Volume expansion with isotonic saline at 1.5–2.5 maintenance.

Page 19: Hypercalcemia in children and adolescent

• MOA: inhibit the reabsorption of calcium, especially in the presence of sodium, further promoting calciuresis.

Page 20: Hypercalcemia in children and adolescent

• Furosemide :• 1–2 mg/kg/d, as divided doses every 4–6

hours.• 1mg/kg every six hours.• It works within hours and can lower serum

calcium levels by 1-3 mg/dL within a day.

Page 21: Hypercalcemia in children and adolescent

• If hypercalcemia does not respond to initial measures, agents that block bone-resorption may be useful as adjuvant therapy.

• Insome cases, hypercalcemia is due osteoclastic bone resorption.

• agents that inhibit or destroy osteoclasts will be effective treatments.

Page 22: Hypercalcemia in children and adolescent

• MOA:• 1- increasing renal calcium excretion .• 2- by decreasing bone resorption via

interference with osteoclast function• works within hours.• lowering the serum calcium concentration

by a maximum of 1 to 2 mg/dL (0.3 to 0.5 mmol/L)

• only for 2-3 days because of tachyphylaxis

Page 23: Hypercalcemia in children and adolescent

• given at doses of 2–4 IU/kg SC/IM .• If a hypocalcemic response is noted, then the

patient is calcitonin-sensitive and the calcitonin can be repeated every 6 to 12 hours.

• it is useful in combination with hydration for the initial management of severe hypercalcemia

• Can be administer along with a bisphosphonate

Page 24: Hypercalcemia in children and adolescent

• is safe and relatively nontoxic • Adverse effects : nausea, abdominal pain,

and flushing.• One benefit of calcitonin is that it has

analgesic properties.

Page 25: Hypercalcemia in children and adolescent

• nonhydrolyzable analogs of inorganic pyrophosphate .

• MOA: inhibit calcium release by interfering with osteoclast-mediated bone resorption by inhibit ing osteoclast action and inducing osteoclast apoptosis

• Helpful when hypercalcemia is primarily driven by the mobilization of calcium from bone as in cases:

• 1-tumor induced hypercalcemia.• 2- immobilization. • 3-vitamin D intoxication • 4- primary hyperparathyroidism

Page 26: Hypercalcemia in children and adolescent

• they are more potent than calcitonin and saline for patients with moderate or severe hypercalcemia .

• Their maximum effect occurs in two to four days• The lowering of serum calcium levels can be of

days to weeks duration

• The nitrogen-containing bisphosphonates, including :

• alendronate, ibandronate, pamidronate, risedronate, and zoledronic acid,

Page 27: Hypercalcemia in children and adolescent

• the most potent inhibitor of bone resorption identified to date.

• 0.025-0.05 mg/kg intravenously IV over 30-45 minutes.

• is superior to pamidronate in reversing hypercalcemia related to malignancy

Page 28: Hypercalcemia in children and adolescent

• Bisphosphonates are extremely effective in children with moderate to severe hypercalcaemia

• 0.5–1 mg/kg/dose of pamidronate as an IV infusion over 4–6 h

• they decrease serum calcium in 2-4 days with a nadir at 5-7 days.

• may last for 2–4 weeks

Page 29: Hypercalcemia in children and adolescent

Pamidronate

• Side effects:

• Fever, arthralgias, myalgia, fatigue, bone pain.

• hypocalcemia, hypophosphatemia, and hypomagnesemia.

• Uveitis.

• impaired renal function, nephrotic syndrome

• osteonecrosis of the jaw*.

Page 30: Hypercalcemia in children and adolescent

• Neridronic acid is an IV/intramuscular (IM) bisphosphonate currently licensed in Europe; some pediatric data are available, including some in neonates.

Page 31: Hypercalcemia in children and adolescent

Decrease Intestinal Calcium Absorption

• Glucocorticoid • MOA: • prevent renal calcium reabsorption• inhibit the production and activity of 1,25(OH)2D, thus

decreasing intestinal calcium absorption

• Uses:• vitamin D intoxication.• in patients with chronic granulomatous diseases (eg,

sarcoidosis) .• patients with lymphoma.• Idopathic infantile hypercalcemia.

Page 32: Hypercalcemia in children and adolescent

• Prednisone at 1–2 mg/kg/d (or 20–40 mg/m2/d), given as divided doses every 4-12 hours

• Hydrocortisone 1mg/kg dose 12 hourly.

• dexamethasone 0.4 mg/kg/day

• onset of action is expected within 24–72 hours.

• Steroids can be combined with calcitonin

Page 33: Hypercalcemia in children and adolescent

• Cinacalcet • MOA: It changes the configuration of the

transmembranal calcium-sensing receptor on chief cell of parathyroid gland in a manner that makes it more sensitive to serum calcium.

• lowers PTH levels• Also results in concomitant decrease of

serum calcium levels by affecting renal reabsorption.

Page 34: Hypercalcemia in children and adolescent

• Uses:• NSHPT• chronic renal disease and secondary

hyperparathyroidism.

Page 35: Hypercalcemia in children and adolescent

• can be used in life-threatening cases .• particularly in patients with renal failure• haemodialysis is more effective than

peritoneal dialysis at lowering calcium levels.

Page 36: Hypercalcemia in children and adolescent

• is recommended for all children with primary hyperparathyroidism.

• Including NSPHT.• Subtotal parathyroidectomy can be

performed, or complete parathyroidectomy can be chosen with reimplantation of a small amount of tissue in the forearm.

• Neonatal severe hyperparathyroidism requires total parathyroidectomy

Page 37: Hypercalcemia in children and adolescent

Intervention Mode of actionOnset of action

Duration of action

Isotonic salineRestoration of intravascular volumeIncreases urinary calcium excretion Hours

During infusion

CalcitoninInhibits bone resorption via interference with osteoclast functionPromotes urinary calcium excretion

4 to 6 hours

48 hours

Bisphosphonates

Inhibit bone resorption via interference with osteoclast recruitment and function

24 to 72 hours

2 to4 weeks

Loop diureticsIncrease urinary calcium excretion via inhibition of calcium reabsorption in the loop of Henle

HoursDuring therapy

Glucocorticoids

Decrease intestinal calcium absorptionDecrease 1,25-dihydroxyvitamin D production by activated mononuclear cells in patients with granulomatous diseases or lymphoma

2 to 5 daysDays to weeks

CalcimimeticsCalcium sensing receptor agonist, reduces PTH (parathyroid carcinoma, secondary hyperparathyroidism in CKD)

2 to 3 daysDuring therapy

Dialysis Low or no calcium dialysate Hours During treatment

Page 38: Hypercalcemia in children and adolescent
Page 39: Hypercalcemia in children and adolescent

• A 2-year-old girl presents to the emergency department with abdominal pain, constipation, and vomiting without fever. The parents report that she lost her appetite in the last few days and has been drinking and urinating more than usual. Physical examination reveals an elevated blood pressure of 137/89 mm Hg; there is mild diffuse tenderness of the abdomen. Her dietary history is unremarkable except for the fact that she does not like to drink milk, so for several weeks she has been taking 1 mL of a liquid cholecalciferol (vitamin D3) preparation that her parents purchased through the Internet. When you ask to see the bottle, you note that the concentration is 5000 IU cholecalciferol per milliliter.

Page 40: Hypercalcemia in children and adolescent

• Laboratory test results:• Calcium = 14.7 mg/dL (3.68 mmol/L) (reference

range: 8.5-10.5 mg/dL [2.13-2.63 mmol/L])Phosphorus = 5 mg/dL (1.6 mmol/L) (reference range: 3.6-6.0 mg/dL [1.2-1.9 mmol/L])Intact PTH, undetectable25-Hydroxyvitamin D = 109 ng/mL (20-68 ng/mL) (272.1 nmol/L [49.9-169.7 nmol/L])1,25-Dihydroxyvitamin D = 82 pg/mL (15-75 pg/mL) (213.2 pmol/L [39.0-195.0 pmol/L])Intravenous normal saline is initiated, and the parents are instructed to discontinue the vitamin D supplement.

Page 41: Hypercalcemia in children and adolescent

• Which one of the following statements about vitamin D metabolism is true?

A. Vitamin D is predominantly cleared by the kidneys, allowing for quick correction of hypercalcemia once the drug is discontinued

B. 1,25-Dihydroxyvitamin D has a long half-life, which will result in prolonged hypercalcemia even after the cholecalciferol is discontinued

C. 25-Hydroxyvitamin D has a short half-life, so the effects of the overdose will be quickly reversed once the drug is discontinued

D. Cholecalciferol has a large volume of distribution, which can result in prolonged hypercalcemia

E. Most 25-hydroxyvitamin D will be converted to 24,25-dihydroxyvitamin D, allowing for rapid correction of the hypercalcemia

Page 42: Hypercalcemia in children and adolescent

• A 10-year-old girl presents to her pediatrician with severe back pain after falling while kicking a soccer ball. Radiographs show severe osteopenia and multiple compression fractures throughout the thoracic spine. Upon questioning, the family reports she has been fatigued for the past several months and has had worsening constipation over the past few weeks. Laboratory workup shows the following:

• Calcium = 13.5 mg/dL (3.38 mmol/L) (reference range, 8.8-10.8 mg/dL [2.2-2.7 mmol/L])

Page 43: Hypercalcemia in children and adolescent

• Phosphorus = 3.8 mg/dL (1.2 mmol/L) (reference range, 4.0-5.5 mg/dL [1.3-1.8 mmol/L])Spot urine calcium-to-creatinine ratio = 1.8 mg/mg (reference range, <0.2 mg/mg)25-Hydroxyvitamin D = 80 ng/mL (199.7 nmol/L) (reference range, 20-80 ng/mL [49.9-199.7 nmol/L])White blood cell count = 28,000/µL (28.0 x 109/L) (reference range, 4300-10,800/µL [4.3-10.8 x 109/L])Hemoglobin = 8.4 g/dL (84 g/L) (reference range, 12.0-16.0 g/dL [120-160 g/L])Platelet count = 105 x 103/μL (105 x 109/L) (reference range, 150-400 x 103/μL [150-400 x 109/L])PTH = <3 pg/mL

Page 44: Hypercalcemia in children and adolescent

• Which of the following is the most likely etiology of this patient’s hypercalcemia?

• CHOOSE ONE• A. An inactivating mutation in the gene encoding

the calcium-sensing receptor • B. Increased intestinal calcium absorption • C. Destruction of bone tissue by invasion from

tumor cells• D. Increased production of 1,25-dihydroxyvitamin

D • E. Activation of the PTH-1 receptor

Page 45: Hypercalcemia in children and adolescent

• You are asked to consult on a 1-month-old infant in the neonatal intensive care unit with hypercalcemia. He was delivered by emergency cesarean section due to placental abruption and fetal heart decelerations. He was floppy, cyanotic, and unresponsive at delivery and required prolonged resuscitation. He was intubated immediately and put on a cooling regimen at 2 hours after birth. On his fifth day, he developed a rash on his back (Figure). The rash resolved over the next 2 weeks.

Page 46: Hypercalcemia in children and adolescent
Page 47: Hypercalcemia in children and adolescent

• He remains intubated. He has had normal laboratory study results until yesterday, when his serum calcium was elevated at 12.7 mg/dL (3.17 mmol/L).

• Of the following, in contrast to patients with hypercalcemia resulting from immobilization, your patient would MOST likely be expected to have

• A. higher parathyroid hormone set point • B. hypercalciuria • C. increased calcitriol synthesis • D. increased osteoclastic activity • E. reduced osteoblastic activity

Page 48: Hypercalcemia in children and adolescent

• You are seeing a 16-year-old adolescent in your clinic with hypercalcemia. She had been seen in the urology clinic previously with repeated episodes of nephrolithiasis, and was found to have a serum calcium concentration of 10.8 mg/dL (2.7 mmol/L). She is a student in school and when seen in your clinic her height is 162 cm and her weight is 75 kg. She has normal facies. Her general physical examination is also normal.

• You obtain the following laboratory studies: • Phosphate 3.1 mg/dL (1.0 mmol/L) (RR 0.8-1.45

mmol/L) • PTH 8 pg/ml (RR 15-65 mmol/L) • 24 hour urine calcium: 400 mg/24 hours

Page 49: Hypercalcemia in children and adolescent

• Of the following genetic tests, the MOST likely to be positive in this patient is

• A. activating PTHR1 (PTH/PTHrP receptor) mutation

• B. compound heterozygous inactivating CYP24A1 (24-hydroxylase) mutations

• C. dominantly inherited CDC73 (parafibromin) mutation

• D. hemizygous 7q11.23 deletion including general transcription factor IIi

• E. heterozygous gain of function CASR (calcium sensing receptor) mutation

Page 50: Hypercalcemia in children and adolescent

• A 9 year old girl presents with confusion, vomiting and abdominal pain .she is tachycardia. On blood tests, her creatinine is 1.8 mg/dl, BUN 45, and her calcium is 14.2 mg/dl. what is th most appropriate initial management.

• 1- furosemide 1mg/kg IV.• 2-pamidronate 0.5-1 mg/kg.• 3-isotonic saline bolus IV.• 4-calcitonin SC.• 5- dietary calcium restriction.

Page 51: Hypercalcemia in children and adolescent

• Treatment with a bisphosphonate can cause which adverse effects?

• 1- hypocalcemia and hyperphosphatemia.• 2- hypophosphatemia and vit d defciency.• 3- flu like symptoms and hypocalcemia.• 4- ostonecronesis of jaw and vitamin d toxicity.• 5-erosive esophagitis and

hypoparathyrodisim.

Page 52: Hypercalcemia in children and adolescent

• A 16 year old male was found to have hypercalcemia during an admission for appendicitis he has been generally healthy , and has not had any fractures ,or kidney stones. His father had two failed parathyroidectomies. And his 26 year old sister also had a parathyroidectomy but still has high calcium .there are no other endocrine disorder in his family .

• His exam is unremarkable. His laboratory tests include : ca 11mg/dl (2.8 mmol/l), phosph 2.5 mg/dl (0.83 mmol/l), ALK 122 , 25hydroxy vit d 44 ng/ml (109.8), 1,25(OH)2 vitamin d and creatinine normal and his urine calcium is 40mg/24hr. PTH is 75 pg/ml (normal 10-65 pg/ml)

Page 53: Hypercalcemia in children and adolescent

• what is the most appropriate next step management?

• 1- referral to surgery for parthyroidectomy..

• 2- IV bisphosphonate.• 3- calcium restricted diet• 4- no specific treatment.• 5- oral bisphosphonate.

Page 54: Hypercalcemia in children and adolescent

• A 26 year old woman gives birth to a full-term baby girl. She feeds poorly, vomits and becomes lethargic in the neonatal period . Family history is notable for multiple family member s with mild hypercalcemia despite attempted parathyroidectomy including mother whose calcium is 11mg/dl (2.8 mmol/l) .the infant tachycardic, and dose not have dysmorphic features. Otherwise exam is unremarkable.

• Her cbc normal ,ca is 17 mg/dl (4.3mmol/l) phosphorus 4.2 mg/dl (1.4mmol/l) creatinine is 1.7 mg/dl and PTH is 425pg/ml .she is started on IV fluids

Page 55: Hypercalcemia in children and adolescent

• Which of the followinf best charactizes her disorder?

• 1- parathyroidectomy can be life saving.• 2- her mother is vitamin D toxic causing baby

hypercalcemia.• 3- the baby is profoundly vitamin D deficient

causing secondary hyperparathyrodisim.• 4-The baby father is carrier for inactivating

vitamin d receptor mutation • 5- no specific treatment is required.

Page 56: Hypercalcemia in children and adolescent

• In counseling about pamidronate therapy , which one of the following is correct?

• A-patient may experience bone pain because pamidronate is a potent stimulator of osteoblasts.

• B- regular dental evaluation are important because ostonecrosis of the jaw is a frequent complication of pamidronate therapy in children.

Page 57: Hypercalcemia in children and adolescent

• C-Future fertility may be compromised because pamidronate has a half life of many years.

• D- hypocalcemia can occur during treatment.

• E- esophagitis can be avoided by remaining upright for 30 min after the pamidronate infusion.

Page 58: Hypercalcemia in children and adolescent

• A 6 year-old , previously healthy boy was in motor vechile crash 6 weeks ago , resulting in a spinal cord injure and paraplegia. He has been living in resdintal rehabilitation facility reciving daily physical therapy . He consumes a regular oral diet including one can of pediatric nutrinional drink daily.his calcium intake is estimated to be 1000mg daily and his vitamin D intake is 600 IU daily . Over last 2 weeks his caregiver have noticed decreased appetite, nausea and increased urination.

Page 59: Hypercalcemia in children and adolescent

• Laboratory test result: • Electrolyte normal• BUN 18 mg/dl (5-18)• Cretinine 0.5 mg/dl (0.16-0.39)• Calcium 13.1 mg/dl (8.5-10.5 mg /dl)• Intact PTH <3 pg/ml (16-65)• ALK 126 (129-291)• 25 hydroxy vitamin d 52.2 ng/ml (25-80)• Which of the follwing best explaines this

patient’s hypercalcemia?

Page 60: Hypercalcemia in children and adolescent

• A- suppresed PTH secretion inhibiting urinary calcium excretion.

• B- increased one alph hydroxylase activity in kideny.

• C- excessive dietry calcium and vitamin d intake.

• D- increased bone resorption resulting in skeletal release of calcium .

• E- ectopic PTH related protien secretion induced by spinal cord inflammation.

Page 61: Hypercalcemia in children and adolescent

• A 10 month old girl presents to the pediatrician with poor weight gain .she was the product of full term .uncomplicated pregnancy and delivery except for birth weight of 2200 g (-2.8SD) no infectious causes for intrautrine growth retardation were idintified and she was discharged to home at 3 days of age. She was formula fed 4 ounces every 3 hours, but she has not tolerated solid food because of swallowing problem she takes no medication her parents describe her as being otherwise well with only mild delay in developmental mile stones

Page 62: Hypercalcemia in children and adolescent

• On physical she appears irritable and weak with decreased muscle tone and normal vital signs. Weight is 6.5 kg (-3SD), length is 61.5 cm (-3.5SD), head circumference is 41.5 (-3.5SD), facies are remarkable for upslanting palpebral fissure,epicanthal folds,shallow nasal bridge, long philtrum ,wide mouthand micrognathia.

Page 63: Hypercalcemia in children and adolescent

• Lab:• Ca 20 mg/dl (8-10.5)• Phosphorus 4.5 mg/dl (3.2-6.3)• Creatinin 0.6 mg/dl (0.2-0.4 mg/dl)• Urinary calcium to creatinine ratio 1.9 (<0.6)• PTH 13.4 pg/ml (16-87)• ALK 186• 25 hydroxy vit d 31ng/ml • 1.25 hydroxy vit d <8 ng/ml (24-86 ng/ml)

Page 64: Hypercalcemia in children and adolescent

• Cardiac evalution demonestrate peripheral pulmonic stenosis, renal us shows bilatral mild echogencity of medullary pyramids chromosomal microarray reveals 1.4-Mb contiguous gene deletIon in 7 q11.23

Page 65: Hypercalcemia in children and adolescent

• At age of 7 years this child will most likely exhibit which of the following?

• A-hypercalcemia.

• B- immune deficency.

• C- thrombocytopenia.

• D-Renal insufficency

• E- normocalcemia.

Page 66: Hypercalcemia in children and adolescent

• Which of the folowing is true about bisphosphonates?

• A-in excess, they paradoxically decrease bone density.

• B-they are administered by deep IM injection.• C- they act by incorporating into bone marrow

precurser cells, thus prolonging their life span.

• D-they augment bone mineralization by increasing osteoblastogenesis.

• E- they are retained in bone for many years.

Page 67: Hypercalcemia in children and adolescent

• Which of the following describe the william-beuren syndrome of infantile hypercalcemia?

• A- chactrized by mitral valve prolapse , extremely fine facial features and overgrowth.

• B- it is realted to loss of function of BAZ1B.• C- it is the result of increased functional activity of

WINAC (WSTF)• D- it is dependent on increased activity of hepatic

25 hydroxylase.• E- it is transmitted as a sex linked recessive trait.

Page 68: Hypercalcemia in children and adolescent

• A 13 year old girl presents with fatigue, cough dyspnea and ployurea. She is tachycardic and her blood pressure is 87/46 . She has joint swelling and wheezes on exam. She has lymphadenopathy on chest radiographs. Her laboratory test result are:

• Total calcium 13.4 mg/dl (3.4mmol/l)• Phosphorus 4.2 mg/dl (1.4 mmol/l)• Creatinine 2.1 mg/dl (168 ummol/l)• PTH <5pg/ml (<0.53 pmol/l)• 1,25 dihydroxy vitamin D 112pg/ml (291 pmol/l)

Page 69: Hypercalcemia in children and adolescent

• What is true about appropriate intial management of hypercalcemia in this patient?

• A- diuretics alone will be effective for mangement.• B- treatment with an IV bisphosphonate can

acutely worsen renal function.• C- urgent parathyroidectomy is required and can

be life saving• D- an IV bisphosphonate will begin to lower

serum calcium faster than calcitionin• E- isotonic saline should be given only after

bisphosphonate have safely lowered the calcium.

Page 70: Hypercalcemia in children and adolescent

• You are evaluting a patient with hypercalcemia associated with an increased PTH level. Before referring your patient to a parathyroid surgeon , you remember from studies for the board examination that you need to exclude FHH as acause of benign nonoeprative hyperparathyrodism . You also remember that the cutoff for diagnosis of FHH is calcium creatinine clearence ratio of less than 1%.as happen most of the time in real life and not on exam , the results come back with CaCl/CrCl ratio of exactly 1%

Page 71: Hypercalcemia in children and adolescent

• What is the quickest ,easiest , and least expensive way to make the diagnosis of FHH?

• A- check serum calcium of patients parents.• B- send DNA for mutation analysis of CaSR

gene.• C- assess whether calcium loading is able to

suppress PTH.• D- measure urinary cyclic AMP in response

to PTH infusion.

Page 72: Hypercalcemia in children and adolescent

• At the insistence of her mother, a 12 year old girl is referred to you by her primary care physician following a pathologic fracture of her left proximal femur. The mother has done extensive research in internet and insist that you do gene testing to diagnose her daughters disorder her physical examination is normal except for a large ragged bordered hyperpigmentated macular lesion extending from her midline toward her right shoulder.

Page 73: Hypercalcemia in children and adolescent

• You decide to biopsy an area of affected tissue to test for mutation in which of the following gene?

• A- CASR.• B-GNAS• C- neurofibromin• D- menin

Page 74: Hypercalcemia in children and adolescent

MCQ 17MCQ 17

• A 14-year-old, previously healthy white girl presents with clinical and biochemical features of pancreatitis and nephrolithiasis at an outside hospital.

• She has a history of a 25-lb weight loss and has been trying to lose weight.

Page 75: Hypercalcemia in children and adolescent

• serum calcium level of 15.0 mg/dL (3.75 mmol/L), • serum phosphorous of 2.2 mg/dL (0.71 mmol/L), • serum magnesium of 1.3 mg/dL. • She has normal blood urea nitrogen of 14

mg/dL(5 mmol/L) • serum creatinine of 0.6 mg/dL (53.04 μmol/L). • Her serum 25-hydroxyvitamin D concentration is

9 ng/mL (22 nmol/L).• Her 125-hydroxyvitamin D concentration is 118

pg/mL (307 pmol/L).

Page 76: Hypercalcemia in children and adolescent

• Of the following, the MOST likely reason for her hypophosphatemia is

• A. inadequate dietary phosphate

• B. primary hyperparathyroidism

• C. refeeding syndrome

• D. tertiary hyperparathyroidism

• E. vitamin D deficiency

Page 77: Hypercalcemia in children and adolescent

MCQ 18MCQ 18

• A 3-day-old newborn presents with lethargy, poor suck, and vomiting. The mother’s pregnancy was uneventful and there was no history of maternal illness. The newborn’s physical examination is unremarkable.

Page 78: Hypercalcemia in children and adolescent

• Laboratory evaluation showed the following:

• PTH, 80 pg/mL

• Total calcium, 14.0 mg/dL

• Ionized calcium, 7.1 mg/dL

• Phosphorus, 1.3 mg/dL

• 25 hydroxyvitamin D, 30 ng/dL

• 1,25-dihydroxyvitamin D, 72 ng/mL

• Urine calcium/creatinine ratio, 0.3

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• Of the following, the MOST likely cause of this newborn’s hypercalcemia is

• A. heterozygous inactivating mutations of the calcium-sensing receptor

• B. homozygous activating mutations of the calcium-sensing receptor

• C. homozygous inactivating mutations of the calcium-sensing receptor

• D. maternal hyperparathyroidism

• E. maternal hypocalcemia

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MCQ 19MCQ 19

• 3 year old boy presented with loss of mandibular incsior without trauma . Refer to you by dentist when he notice mild root resorption.

• On eaxm patient having widened wrists and ankle. Lab showed:

• Bicarb 27 ,albumin 3.9 g/dl , calcium 10.2 mg/dl ,phosphorus 6.2 mg/dl , Alkaline phosphatase :65 U/L PTH 25 pg/ml

• Vitamin d 25 hydroxy 30 ng/ml

Page 81: Hypercalcemia in children and adolescent

• Clinical finding in this patient most likely due to :

• A- increased bone resorption.

• B- increased inorganic pyrophosphate.

• C- increased phosphate .

• D- blount disease.

• E. increased FGF23

Page 82: Hypercalcemia in children and adolescent