Hydrolyzed DNA regaining the beauty with the vitality by stopping the clock of aging. After we have studied the source of life, DNA, for a long time, we have made the innovation of genetic dermatology for healthy skins. Beauty starts from healthy and powerful skins. HYDROLYZED DNA CELL POWER, ANTI-AGING, MOSTURIZING SOLUTION NUCLEO DNA CARE SOLUTION FOR YOUR BRAUTY & HEALTH www.nucleo.co.kr 中文 ENGLISH
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Hydrolyzed DNA regaining the beauty with the vitality by stopping the clock of aging.After we have studied the source of life, DNA, for a long time, we have made the innovation of genetic dermatology for healthy skins. Beauty starts from healthy and powerful skins.
HYDROLYZED DNA CELL POWER, ANTI-AGING, MOSTURIZING SOLUTION NUCLEO
DNA CARE SOLUTIONFOR YOUR BRAUTY & HEALTH
www.nucleo.co.kr
中文ENGLISH
Pores Sebaceous glands
Abandonment of layer
Granular Visible layer
The bottom layer
Tube glands
Coliseum hair roots
Fiber
Sweat gland
Fur pouch
cuticle
Dermis
Sub
cuta
neo
us
tissu
e
Thin skin, an enlarged picture EpidermisParts in contact with the outer surface = there are no skin blood vessels and nervous tissues on the surfaceIt consists of five layers such as stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum and stratum basale. Closely related to cosmetics
DermisLayer made up of the skin = skin = including blood vessels, nerves, lymphatic duct, sweat gland, sebaceous glands, etcIt is made up of collagen, elastin, fibroblasts and substrates. It is closely related to skin elasticity.
Subcutaneous fatIt is present in the skin at the lowermost layer. It is closely related to hormones.It protects internal organs from external physical shock and maintains the body temperature.
irritantsmicro-organisms, allergens
irritantsmicro-organisms, allergens
The structure of the skin
What is Hydrolyzed DNA ?
Decrease in activity of skin cells – aging skin
What is the solution to figure out skin aging and skin troubles ?
Normal skin vs atopic skin
Various irritants easily enter the skin of patients with atopic dermatitis and cause inflammation and immune responses. Moisture of skin is easily evaporated (TEWL increase)
The most important cause for itching and dry skin which are common symptoms of atopic dermatitis is the damage of skin barrier which is a skin protective film.
Normal skin plays a protective role against various external irritants and prevents evaporation of moisture on the skin.
You must let skin cells of the dermis by waking up dormant skin cells.To restore the physiological and biochemical homeostasis which is the normal function of skins,- Cell regeneration, activation of cell production, healthy cells- Promotion of collagen production- Improvement on moisturizing power- Young skinNucleic Acid (DNA) multiplies fibroblasts, and Increased fibroblasts activate the collagen production.In turn this process improves skin firmness.
Hydrolyzed DNA_Oligo(Low molecular weight, hydrolysis) DNAIt is the ingredient to improve the permeability into the skin by specially treating DNA with enzymes and making it in low molecular weight.NUCLEO ATO-DNA product is the world’s first cosmetics to implement double moisturizing on inner and outer skins and improve the permeability into the skin by compounding DNA-Na in high molecular weight and DNA (low molecular weight and hydrolyzed DNA).Experimental results are obtained in which the skin texture gets much better when Hydrolyzed DNA is used. In addition, it has the effects to promote the reduction of wrinkles and increase in sebum moisture.In addition, it helps to cure wounds or activates metabolism by activating the cells. It also acts as the anti-oxidant function in deep skin. Fresh and healthy skins are made by improving turnover of the skins.
Key Effect Field of Application Passing the stability test
Anti-aging lineMoisturizer for drynessCalming troubled skin All-in-one gel Hair growth promoter toothpaste
Eye-irritant testAcute toxicity testFirst skin-irritant test Back mutation test
TH,immunantwort
Langerhans cells Langerhans cells
Inflammation/exacerbation
of AD
DoubleMoisturizing
Cell
HYDROLYZED
CollagenDNA
General moisturizing ingredients HYDROLYZED
DNA
MAGICAL 'S ADVANCEDDEMATOLOGICAL TECHNOLOGIES...IT IS
HYDROLYZED DNA Micro-Molecular Standard Material Comparison of competitive ingredients
A salmon extract, refined DNA, becomes micro-molecular and improves in functionality to make it proper cosmetic mixed ingredients
asement membrane peptides (Hexapeptide)Six amino acid sequences which are shared by collagen-4 and collagen-17 composing the basement membrane are synthe-sized in peptides.Wound is recovered by rapidly regenerating the basement membrane which is the basis of differentiation of the epidermis. Regeneration effects are confirmed in cells, artificial skins and clinical tests.
Peptide (Various polypeptides consisting of amino acids)Most raw materials are peptides which mimic the functional groups of proteins present in the body. Each raw material contains various effects. In general, if it has more amino acids composing peptides, it is expensive and unstable.It mostly consists of 3 – 4 amino acids. Not many peptides show the actual regeneration effects.
Snail slime (Allantoin, collagen, elastin, glycolic acid, vitamin A, D, E)Allantoin, Glycolic acid : substantial effects on patients with large burns. Burn scabs are promptly removed. Promotion of peeling of the epidermis (removal of dead skin cells), promotion of cell proliferation, removal of necrotic tissue and moisturizingContaining 80 % as raw material in Elicina cream – there is no ingredient giving the direct regeneration effect. However, it is used for moisturizing after the skin treatment, because of the sense of moisture caused by the sense of membrane of Snail slime. However, it does not have the regeneration effect at all.
EGF(Recombinant Human Epithermal Growth Factor)Epidermal growth factor _ It represents a broad skin regenera-tion effect, but it does not penetrate into the skins because of very high molecular weight.It can be degraded by proteolytic enzymes present in the skin. It is toxic at high concentration.
Registered name in INCI as cosmetic mixed ingredients:Hydrolyzed DNA Indication of Name : hydrolysis DNA-Na
Hair growth promoter effect by Hydrolyzed DNA
Certified for japan patent as a growing hair, hair growth promot-er and anti-hair loss
Growing hair root cells and hair growth promoter
Hydrolyzed DNA increase fundamental power of hair root cells
Hair
Hair root
Sebaceous glands
Hair root cells
Hair papilla
Blood vessel
Efficacy data as cosmetics of oligo DNA
Not containingHydrolyzed DNA
Before use After 4 weeks Before use After 4 weeks Before use After 4 weeks Before use After 4 weeks
ContainingHydrolyzed DNA
Inhibitory effect on capacity of collagen production
Hydrolyzed DNA shows absolutely higher capacity of collagen production compared with other moisturizing ingredients.
Normal DNA
Not containingHydrolyzed DNA
ContainingHydrolyzed DNA
Not containingHydrolyzed DNA
ContainingHydrolyzed DNA
Hydrolyzed DNA
Skin damage is reduced by significantly inhibiting the increase of Hydrolyzed DNA caused by UVB.
Amount of moisture retention in the skin
Result of comparison between states of the skin after applying cream containing Hydrolyzed DNA and cream not containing Hydrolyzed DNA onto half of face twice a day for 4 weeks.
Calculation of relative ratio of amount of collagen production / number of cellsConcentration of the applied sample : 1mg/ml, treatment time : 24 hours
Skin density
Inhibitory effect on amount of collagenase
HydrolyzedDNA
NormalDNA
Collagen Vitamin Cderivatives
Hyaluronicacid
Control
Improvement effect on atopic dermatitis
No treatment Application of ointmentcontaining oligo DNA
BEFORE AFTER
Disease of thickened skin by scratching the skins.Dry skin accompanying pigmentation (Erythroderma and pruritic exanthema are recognized)Pigmentation is reduced and state of skin disease is improved.
Effect on healing the wound by Hydrolyzed DNA
Effect on healing the wound by Hydrolyzed DNA
Ointment containing Hyarolyzed DNA is applied to 10 cm of head part in half portion of about20Cm of wound. After 7 days, the states of treated and not treated areas are compared. Recovery of wound without treatment is slow and scrab still does not fall off yet. Difference in the wound healing effect is evident
Immediately after wound
Application of ointment containing oligo DNA
No treatment
※ Amount of usage of ointment containing 3 % oligo DNA : 10.5 g = (1.5 g x 1 time) x 7 d
After 24hours After 7days
After 24hours After 7days
ROBOSKIN / ANALYZER TYPE A Left , oil and water analyzer Wave Cyber WSK-P500U
7 people (3 of 60’s, 1 of 50’s、3 of 30’s)Sensitive skin type 4 peopleHealthy skin type 3 people
Elapsed time observed : 5daysApplied time : 14daysElapsed time observed : 7days
Elapsed time observed : Before 5days, 1 dayApplied time : After 3, 7, 10, 14daysElapsed time observed :After 3, 7Days Total 8 times
Moisture・sedum measurement Realistic assessment
The middle of inside forearm 5cmApply one, non-apply an other
1time a day (night)On the test part、skin trouble part
Test time:After 10AMTemperature : 19~27 degrees CelsiusHumidity:40~51%
Test item
Testcondition
Test item
Apply
Before 5days
After3days
After7days
Before 1days
3days 7days 10days 14days
Non-applied Non-appliedApplied
Results of moisture measurement (average of all participants)
Test result of moisture and sebum (average of all participants)
Moisture (0~100)Capacitance of the skin is determined by tightly pressing the center and it is measured with a value representing the moisture. State of measuring physiological saline itself is assigned as “saturation state (100)”, State of no moisture is assigned as “zero state (0)”.
During the application period (from the 3rd day of application to the 14th day of application), oil and moisture levels tend to be improved during the measurement period. There is no difference caused by age in 30s and 50s or older. There are no significant differences in tendency between four people who consider it as sensitive skin and three people who consider it as healthy skin.There are two monitors who feel itchy is improved among three monitors who perceive itching.
Result of measuring sebum content (average of all participants)
Sebum (0~100)Rolled sebum is determined with the refractive index by tightly pressing the sensor part and the area is measured.State of sebum covering the entire side is assigned as “sebum saturation state (100)”,State of no sebum is assigned as “sebum zero state (0)”.
Moisture value (average) Sebum value (average)
Reactive oxygen species (free radical) is considered as an aggravating factor of skin disease atopic dermatitis such as itching getting worse as of today and eczema lesion which repeats the temporary improvement.Oligo DNA with high permeability which plays roles of strong antioxidant, moisturizing activity and cell recovery, DNA-Na working on the skin surface and sphingomyelin which is the source of ceramide having anti-inflammatory effects are mixed.Nomura medical clinic reviewed the improvements on atopic dermatitis by applying cream containing oligo DNA based on symp-toms to patients suffering from atopic dermatitis.
Severity of the skin diseases : The nature and state of skin diseases are determined by observing the degree of skin state of individu-als according to the following items.
Items of skin diseasesPruritus (itching), wetting (muddy), red spots (erythema), edema (swelling), thickening skin that (thickening skin as a chronic skin disease), pigmentation, rough skin (dry), scratched wounds, skin rash (rash bumps on the skin), moisturizing ability
Criteria to determine the degreeHigh : Lesion with highly worsening skin disease items Intermediate : Lesion with intermediate degree of lesion items rather than high degree Low : Lesion with slight hardness and inflammation symptoms compared to that with intermediate degree of lesion No: No changes in lesion symptoms (not worsening and not improving)
Test result by age
Test methods and judging criteria for monitor of patients with atopic dermatitis
Moisture value (average of over 50’s)
Sebum value (average of over 50’s)
Moisture value (average of 30’s)
Sebum value (average of 30’s)
IgE levelIn addition to type I allergic reaction, high level for antibody pollinosis allergic atopic dermatitis specifically responding to allergen is shown. Eosinophilic granulocyteIt is kind of white blood cells and increases as upon occurrence of allergic diseases.LDHIt is lactic dehydrogenase and it increased at the time of damage of cells, tissues or organs. In addition, it also increases when the erythrocyte membrane is damaged. Increased reactive oxygen species is also thought to be one of the causes
Oxidative stresses caused by reactive oxygen species (free radicals), dry blood (blood fragility test)�Professor Dr. Ockerman (Sweden) used judging criteria for reactive oxygen species activity.In the attached table, a drop of blood is collected and placed on a glass slide. It is observed under a microscope. Scale of reactive oxygen species (Free Radical activity)
• Improvement effect on atopic dermatitis is recognized. In particular, the improvement effect of moisturizing ability is recognized in all skin diseases. •90 % of improvement effects on rough skins and itching is shown. 80 % of improvement effects on scratched skins is shown.•90 % of improvement effect in hardening skin except the fifth one where hardening is originally not shown is recognized.•Because hardening skin accompany chronic process, improvement tendency caused by the use of it for 4 weeks is valuable. •60 % of reduction of pigmentation is recognized.
Evaluation of clinical blood tests (academic allergy tests)
Clinical result of improvement on skin disease symptoms before and after the use
0∼5 Normal
6∼10 Very little mild oxidation stress
11∼15 Mild oxidation Stress
Moderate oxidation stress
High oxidation stress
Very high oxidation stress
16∼25
26∼35
36∼50
Examples of diseases Itchy
skin Swelling of the
skin Rough dry skin
Scratched damaged skin
Red skin Thickening skin
Pigmentation skin
Rash bumps on the skin
Moisturizing ability
NO. Sex Age (%)
Before After Before After Before After Before After Before After Before After Before After Before After Before After
1 W 36 9 2 No No High No Middle No Middle No No No Middle Slight Slight No 22.5 35.3
2 W 26 6 3 Slight No Middle Slight Slight No Slight No Slight No Slight Slight Middle Slight 23.1 30.0
3 W 38 6 2 Slight No Middle No Middle Slight Middle No Middle Slight High Slight No No 29.0 35.5
4 W 34 5 1 No No Middle No Slight No Middle No Slight No Slight No Slight No 20.1 32.1
5 W 36 8 0 Slight No Middle No High No Middle No No No Middle No High No 27.3 33.5
6 W 33 7 5 No No Middle Slight Slight Slight Middle Slight No No Slight Slight Middle Slight 30.9 36.6
7 W 32 8 8 No No Low Slight Slight Slight Slight Slight No No Slight Slight Slight Slight 36.1 39.6
8 M 32 5 1 Slight No Middle Slight Middle No Middle Slight Slight Slight High Slight No No 19.9 24.0
9 M 32 6 2 No No Low No Slight No No No No No No No Slight No 28.5 41.5
10 M 34 6 1 Middle Slight Middle Slight Slight No High Slight High Slight Middle Slight No No 27.6 30.6
Excellent effect : Symptoms are surprisingly improvedEffective : symptoms are clearly improvedInvalid : there is no improvement in symptoms
Effect of cream containing oligo DNA on improvement of atopic skin diseases is proven. As shown in the following figure, 90 % of monitors recognize the effect of improvement on skin diseases.
Comprehensive evaluation of clinical outcome
•As the allergy academic observation, a total of IgE level, eosinophilic granulocyte, LDH level and reactive oxygen species are added and reviewed. •As examples of atopic skin diseases representing chronic process are subjects, high level of total IgE is shown and a significant differ-ence is not shown.• Improvement in eosinophilic granulocyte and LDH level is recognized before and after the use.•For reactive oxygen species caused by Dry Blood, it shows 35 and medium ~ high oxidative stress state in all skin diseases before the use. However, the average level is 30, which is decreased by 5 after the use. •Reduction of oxidative stress is recognized.
From compounding ingredients of 「oligo DNA cream」, three kinds of improvement effects on major skin function are largely shown. Maintenance of skin functions, anti-inflammatory action and anti-oxidant action are given by activating epidermal cells of skin with both oligo DNA and DNA-Na. Action is taken to correct the confusion of side balance of allergic diseases. Production of ceramide acid which is moisturizing ingredient is promoted by metabolism of sphingomyelin.In addition, moisturizing action caused by collagen (improvement of moisturizing ability increases the function of forming skin film)It is thought that improvement effect on atopic skin diseases is caused by inhibition of allergic inflammation and enhancement of immunity with above three improvement actions of skin function.
Clinical result of improvement on clinical blood test before and after the use
NO.
Examples of diseases
Gross IgE IU/mℓ Eosinophile LDH IU/ℓ Dry Blood
Sex Age Before After Before After Before After Before After
1 F 36 4360 4043 430 670 249 466 30 25
2 F 26 4850 5400 240 260 348 412 38 35
3 F 38 1075 928 140 130 333 172 38 34
4 F 34 6300 6600 870 1070 201 195 38 30
5 F 36 399 400 460 320 316 271 35 30
6 F 33 76 74 180 190 224 228 37 37
7 F 32 8330 8750 1000 1090 222 191 35 37
8 M 32 5260 5420 430 470 213 207 23 22
9 M 32 8350 7970 430 340 197 203 35 27
10 M 34 1194 1177 2360 454 434 235 37 18
Average 4019 4076 654 454 274 235 35 30
Case of taking nucleic acids and using cream containing DNA
List of those who experience nucleic acids + DNA cream and comparison before and after administration (Test from the end of October, 2013 to January 28th 2014)
Kim, University student (female), Taking it on 19-Nov-2013 / Start the use
Uhm, Middle scholo student (girl), back part of neck Taking it on 27-Nov-2013 / Start the use
Choi, Primary school student (boy), neck part, Taking it on 24-Nov-2013 / Start the use
Choi, Primary school student (boy), chest part, Taking it on 24-Nov-2013 / Start the use
Taking it, before using it19-Nov-2013
Taking, on the 16th day of using it2-Dec-2013
Before use After 12 days
Before use After 4 days Before use After 6 days
No 。
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
KimKwonYangKwonRyuLeeSinKim
Choi
UhmGaLeeJangKwon
KwonKim
Ryu
Middle School teacher
High school teacher
Construction business owner
Import business owner
Housewives
Import business owner
Sports magazine team leader
College students
Elementary school students
CEO in shipping company
Housewives
CEO in consulting company
Director in advertising agency
Middle school students
Elementary school student
Section head in �Hyundai motors
Grandmother
Chronic fatigue, Knee ligament pain
Chronic fatigue
insomnia
wrist pain, both knee cartilages, scalp seborrheic dermatitis
Reduction of fatigue, reduction of melasma, reduction of gastric pain
Reduction of fatigue, improvement of neck psoriasis
Reduction of pain
Improvement in one week
Improvement in one week
Reduction of fatigue
Complete recovery of Shingles, allergic rhinitis (2 weeks)
Recovery from a cold in 4 days
Smooth sleeping
Significant reduction of pimples, clean
Significant reduction of pimples, clean
Better bowel movement
Better digestion without taking digestive medicine
51
49
50
46
45
50
45
20
12
50
47
48
45
14
13
42
70
Name Age Occupation Physical condition before taking it Improvement effect After taking it
This report is the confidential document and property of the Ko rea Institute for Skin and Clinical Sciences;its transfer, plagiarization, and disclosure to thir parties is prohibited.
Results
No skin reaction was noticed at 30 minutes and 48 hours after removing patch
of Hydrolyzed DNA Cell Power Serum on the test area. Although ±irritation was
observed from one subject after 24 hours, the test material can be considered
as non irritant, regarding the mean score obtained was 0.17. No skin reaction
was noticed by the dermatologist at 30 minutes, 24 hours and 48 hours after
removing patch of Hydrolyzed DNA In-Deep Cell Power Mask on the test
area and the mean score obtained was 0.00. Thus, the test material can be
considered as non irritant. No skin reaction was noticed by the dermatologist
at 30 minutes, 24 hours and 48 hours after removing patch of Hydrolyzed DNA
Cell Power Mask on the test area and the mean score obtained was 0.00.
Thus, the test material can be considered as non irritant. No skin reaction was
noticed at 30 minutes and 24 hours after removing patch of ATO-DNA Power
Softener on the test area. Although ±irritation was observed from one subject
after 48 hours, the test material can be considered as non irritant, regarding the
mean score obtained was 0.17. No skin reaction was noticed at 30 minutes, 24
hours and 48 hours after removing patch of Hydrolyzed DNA Cell Power Skin
on the test area and the mean score obtained was 0.00. Thus, the test material
can be considered as non irritant. No skin reaction was noticed at 30 minutes,
24 hours and 48 hours after removing patch of ATO-DNA Wash & Shampoo
on the test area and the mean score obtained was 0.00. Thus, the test material
can be considered as non irritant. No skin reaction was noticed at 30 minutes,
24 hours and 48 hours after removing patch of PURE Bbee Soft Cleanser &
Shampoo on the test area and the mean score obtained was 0.00. Thus, the
test material can be considered as non irritant.
Conclusion
As the result of the safety test of ‘Hydrolyzed DNA Cell Power Lotion and
seventeen other kinds of cosmetics’, requested by TRUSMETICS CORPORATION,
all test materials can be considered as non irritant.
SUMMARY OF THE CLINICAL STUDY
Clinical Study Report
KISCS-CHC-ADE016
A safety test of 'Hydrolyzed DNA Cell Power
Lotion and seventeen other kinds of cosmetics’
after 24 hours patch on human skin
Requested by : TRUSMETICS CORPORATION (Korea)
Performed by : Korea Institute for Skin and Clinical Sciences ( Seoul, Korea)
Date : June 23, 2014
This report is the confidential document and property of the Korea Institute for Skin and Clinical Sciences;its transfer, plagiarization, and disclosure to thir parties is prohibited.
□Title of the clinical study : A safety test of ‘Hydrolyzed DNA Cell Power Lotion and seventeen
other kinds of cosmetics’ after 24 hours patch on human skin
□Case control No. : KISCS-CHC-ADE016
This study was conducted according to the regulations of designation as the test institution for
drugs, quasi-drugs, cosmetics, and medial devices; the guidelines of the management standards
for clinical drug evaluations; the guidelines of in vivo clinical and in vitro evaluation studies;
the guidelines of the experimental methods for cosmetic display and advertisements; and the
guidelines of the validation of functional cosmetics of the Ministry of Food and Drug Safety, Republic
of Korea; the laws of the bioethics and safety of the Ministry of Health and Welfare, Republic of
Korea; and the standard operation procedure of the Korea Institute for Skin and Clinical Sciences.
All procedures were investigated by the person in charge of reliability assurance.
Title of the
clinical study
A safety test of ‘Hydrolyzed DNA Cell Power Lotion and seventeen other kinds of
cosmetics’ after 24 hours patch on human skin
Date Step Categories Result Note
May 26, 2014 Study plan Reporting plan Approved
June 9, 2014 Performing clinical trial Reporting implementation Approved
June 16, 2014 Checking the data Raw data Approved
June 20, 2014 Inspection of draft report Inspecting draft report Approved Oral report
June 23, 2014 Inspection of final report Inspecting final report Approved
This report was prepared on the basis of the experiment results and accurately reflects the data.
June 23, 2014
Scientific director In Sook An, Ph.D. (seal)
Chief researcher Sungkwan An, Ph.D. (seal)
CERTIFICATE FOR RELIABILITY ASSURANCE
This report is the confidential document and property of the Ko rea Institute for Skin and Clinical Sciences;its transfer, plagiarization, and disclosure to thir parties is prohibited.
Title of the clinical study
A safety test of ‘Hydrolyzed DNA Cell Power Lotion and seventeen other kinds of cosmetics’ after 24 hours patch on human skin
Clinical trial institution
Korea Institute for Skin and Clinical Sciences3rd Floor, Life Science Building Annex, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea
For the study initiation, the person in charge of the study signed the clinical study proposal; for the study termination, the person in charge of the study signed the final report.
SubjectsThirty three subjects of either sex who met the inclusion criteria and were not included in
the exclusion criteria were selected for this study.
Name of the test materials
Hydrolyzed DNA Cell Power Lotion and seventeen other kinds of cosmetics
Methods
Thirty three healthy volunteers participated in the patch test using finn chamber
on skin. Each Finn Chambers containing 20 μL of a test material were fixed on
the upper back of the subjects after cleaning up the test area with 70% ethanol
and drying. In the case of a liquefied test material (#15-#18), 20 μL of a test
material was dropped into a filter paper disc fixed on 8 mm finn chamber. #17,
#18 were applied after diluted with sterile distilled water at 1% concentration. The
test area was assessed at 30 minutes, 24 hours and 48 hours after a single
application during 24 hours patch on the subjects. Skin reactions were scored by
a dermatology specialist, following the criterion of International Contact Dermatitis
Research Group (ICDRG).
Results
Requested by CHICCO Co., Ltd., skin reaction was assessed at 30 minutes, 24
hours and 48 hours after a single application during 24 hours patch of ‘Hydrolyzed
DNA Cell Power Lotion and the other kind of cosmetics’ on human skin. According
to the criterion of International Contact Dermatitis Research Group (ICDRG), mean
score was calculated after categorizing the degree of skin reaction. No skin reaction
was noticed by the dermatologist at 30 minutes, 24 hours and 48 hours after
removing patch of Hydrolyzed DNA Cell Power Lotion on the test area and the
mean score obtained was 0.00. Thus, the test material can be considered as non
irritant. No skin reaction was noticed at 30 minutes, 24 hours and 48 hours after
removing patch of PURE Bbee Intensive Care Cream on the test area and the mean
score obtained was 0.00. Thus, the test material can be considered as non irritant.
SUMMARY OF THE CLINICAL STUDY
NON-IRRITANT PRODUCTS PROVED BY KISCS
As Hydrolyzed DNA (low molecular weight DNA) is specially treated with enzymes and made in low molecular weight, itis the ingredient to improve the permeability of the moisturizing ingredient into the skin. With dual moisturizing power in inner and outer skins by combining hydrolyzed DNA and DNA-Na, the skin texture becomes smooth and the increase in the moisture contents of sebum is facilitated. Thus, it helps to improve the turnover of the skin and protect the skin from free radicas.
NUCLEO HYDROLYZED CELL POWER ANTI-AGING SOLUTION
NUCLEO HYDROLYZED CELL POWER ANTI-AGING SOLUTION
Hydrolyzed DNA regaining the beauty with the vitality by stopping the clock of aging.After we have studied the source of life, DNA, for a long time,
we have made the innovation of genetic dermatology for healthy skins.Beauty starts from healthy and powerful skins.
Containing hydrolyzed DNA which is the patented ingredient and which we study the basics of healthy skins with
Magical moisturizing and absorbing power of hydrolyzed DNA made in low olecular weight
Dual moisturizing powers filling and preventing with hydrolyzed DNA and DNA-Na
5 in 1 smart multi care line that can take care of the skin at once withthe addition of dual functional ingredients for anti-wrinkle and whitening
5in1
Whitening
MoisturizingHealthyGlow
Anti-WrinkleFirmness
Main Ingredient of NUCLEO CELL POWER LINE
Efficacy of the main common ingredients NUCLEO CELL POWER LINE
The secrets of DNA CELL POWER efficacy is “ HERE ”
Those 5 ingredients are commonly included in all of the CELL POWER line (toner, lotion, serum, eye cream, cream)Cleansing Foam includes only Hydrolyzed DNA, Sodium DNA and Pomegranate extract.
Adenosine <Functionality of wrinkle reduction> It is the nucleoside involved in signaling out of the cell and it is the raw material directly involved in growth, differentiation and homeostasis of cells. It is notified by KFDA as the raw material to improve the wrinkles.Efficacy _ raw material notified by KFDAIt has a very excellent would healing effect as the ingredient to promote the cell growth. In addition, it relieves the wrinkles and restores the elasticity by promoting the synthesis of collagen in the dermis.
Premium DNA Multi-Care Line to treat all your skin problems.(This is the result of our own evaluation conducted in June, 2014, with about 40 people)
Pomegranate extract Estrone and estradiol in pomegranate have the same structure of hormones secreted in the body compared to any botanical hormones extracted from other natural products. Thus, it is called phytoestrogen.Efficacy As phytoestrogens provide moisture and nutrition with the dermis by increasing the amount of collagen collective tissues which connect each cell, skin dryness and wrinkles are prevented and skins are made transparent, moist and elastic.
Niacinamide <Functionality of whitening> Niacinamide is a water soluble vitamin B3 directly involved in skin whitening.It is the nutrient and vitamin included in green vegetables as an essential ingredient in our body. Efficacy _ raw material notified by KFDAIf the skin is exposed to external conditions such as the sun light or stimulation, melanin pigment is moved in the skin and then blemishes appear in the skin.At this time, it plays a role to reduce the movement of melanin pigment.
NUCLEO HYDROLYZED DNA CELL POWER FOAM 150ml
SpecialtyGives glow and radiance with pomegranate which is similar with female hormoneContains Hydrolyzed DNA to keep skin cell healthy even from cleansing step Cleans off wastes not only inside of skin surface, but also inside of pores
Benefits Hypo-allergenic cleansing with soft bubbleNot dry & tight feels despite powerful cleansing effectGets a pure and transparent skin after washing the face
Cell Power`s specialty given to my skin
Felt the softened skin texture _98%
Felt firmer and lifted skin _98%
Got an instant glow quickly _97%
Felt their skin moisturized by the next morning _95%
The feeling of texture was very soft when applying it on the face _92%
Saw the visible radiance all over face _ 94%
Key Ingredients
No Added Ingredients
How to use
Hydrolyzed DNA, Sodium DNA, Pomegranate extracts
Paraben, Synthetic colorants, Methylated spirit, Mineral Oil, Triethanolamine, Sulfate-based surfactant
Paraben, Synthetic colorants, Methylated spirit, Mineral Oil, Triethanolamine, Sulfate-based surfactant
NUCLEO HYDROLYZED DNA CELL POWR SKIN 120ml
Specialty TrehalosMakes healthy skin barrier to stop the moisture from being evaporated with resurrection plant grown in the desert BetaineNature amino acid extracted from sugar beet is helpful in decreasing dryness and irritation, and obtain long-term hydra-tion Containing Hydration DNA Creates anti-wrinkles and brightening effect by delivering double functional ingredients (Adenosine, Naicinamide)Benefits Hypo-allergenic cleansing with soft bubbleNot dry & tight feels despite powerful cleansing effectGets a pure and transparent skin after washing the face
Key Ingredients
No Added Ingredients
How to use
Hydrolyzed DNA, Sodium DNA, Pomegranate extracts
Paraben, Synthetic colorants, Methylated spirit, Mineral Oil, Triethanolamine, Sulfate-based surfactant
Paraben, Synthetic colorants, Methylated spirit, Mineral Oil, Triethanolamine, Sulfate-based surfactant
Hydrolyzed DNA DNA-NaFormation of a moisturizing protective filmConditioning
SpecialtyLinseed extracts Called an ancient life-giving seed, Linseed gives strong firmness and is very helpful in anti-aging containing enriched Omega-3 Fatty Acid, Dietary Fiber, and Lignan (called phytoestrogen)Containing Hydration DNA Gets glows and firmer skin by containing pomegranate extracts
Benefits Penetrates the skin speedily.Refines the facial line, and crafts radiant skin Soften the skin textureGets the beautiful glows from withinCreates firmer and illuminated skin with quick absorption
Paraben, Synthetic colorants, Mineral Oil, Triethanolamine, Sulfate-based surfactant, Talc
After applying toner, pump two to three times on your palm and apply evenly over your entire face, moving outwards from the center.(Fist pump takes 5 or 10 times )
NUCLEO HYDROLYZED DNA CELL POWER Lotion 120ml
SpecialtyMacadamia nuts OilIt enhances firmness containing enriched Palmitoleic acid which is efficient in strong anti-oxidant Containing Hydration DNA Creates anti-wrinkles and brightening effect by delivering double functional ingredients (Adenosine, Naicinamide)Gets glows and firmer skin by containing pomegranate extracts
Benefits Gives enriched hydration and nourishment on exhausted skin Oil in water emulsion leaves the skin light and refreshed.Reduces the lines on the face and enhances the radianceSoftens the skin surface and balances oil and water inside of the skin.
Mineral Oil, Triethanolamine, Sulfate-based surfactant , Benzophenone, Tal
After applying serum, pump two to three times on your palm and apply evenly over your entire face, moving outwards from the center.(Fist pump takes 5 or 10 times )
NUCLEO HYDROLYZED DNA CELL POWER Eye Cream 35ml
SpecialtyShea butterProtects the hydration protective barrier from harmful external environment by filling the skin with nourishment Stop the skin cells from aging by containing Hydrolyzed DNA Creates anti-wrinkles and brightening effect by delivering double functional ingredients (Adenosine, Naicinamide)Gets glows and firmer skin by containing pomegranate extracts
Benefits Brightens the skin around the eyes, and Reduces the line on the face Enriched Hydrolyzed DNA penetrates the skin quickly Changes the tired eyes into vital and brightening eyes by plump-ing up areas around the eyes Gives firmness on the weak eye rim and rather sensitive skin around the eyes Highly-concentrated essential energy is delivered to the skin speedily
After applying lotion, Take a rice grain-sized amount and gently dot under the eyes. Using your ring finger, gently massage it on your skin in a circular motion..(Fist pump takes 5 or 10 times )
NUCLEO HYDROLYZED DNA CELL POWER Cream 50g
SpecialtyShea butterProtect the hydration protective barrier from harmful external environment by filling the skin with nourishment Stop the skin cells from aging by containing Hydrolyzed DNA Creates anti-wrinkles and brightening effect by delivering double functional ingredients (Adenosine, Naicinamide)Gets glows and firmer skin by containing pomegranate extracts
Benefits Refines the facial line and soften the skin texture. Gives visible firmness while applying it Enriched hydrolyzed DNA penetrates the skin quickly to make healthy skin and the cream adheres closely to skin while leaving skin feel soft and silky.Luxury multi-care cream to include double functional ingredi-ents for anti-wrinkle and brightening.
After applying eye cream, take a pearl-sized amount of the cream and dot your face. Massage gently outwards to spread evenly.
NUCLEO CELL POWER LINE
Cell Power`s specialty given to my skin
HYDROLYZED DNA IN DEEP DNA CELL POWERPREMIUM MASK PACK
3D mask with high quality which shines at any angleIt is a 3D mask with high quality to make new skins, since hydro-lyzed DNA which is a patented ingredient and dual functional ingredients for whitening, anti-wrinkles are fully added on a superfine fiber mask.
Charging the aged cells As regeneration of skin cells is maximized with hydrolyzed DNA ingredient and the production of collagen is promoted by increasing fibroblasts, young proteins for anti-aging are produced. It is a multi anti-aging mask to handle wrinkles, whitening, elasticity, luster and moisturizing which have been skin problems at once by providing skin cells with adequate nutrition.
Lost elasticity UP ! It is the hydrogel mask prepared for sagging V line and it is a child face mask to change the contour of the sagging face into a face with a clear and soft egg line.
Perfection of youthful-looking skin illuminating from any angle!
Enriched Hydrolyzed DNA is drenched in themicro-fiber mask sheets to adhere closely to the skin
and it gives the skin a healthy glow. This premium 3D mask is completed with separately added
hydrogel mask for the jaw-line to refine the facial profile through (called Egg line) lifting.
Step 1, 2 Anti- wrinkle, Whitening CarStep 3 Egg Line Care
3D EGG-LINEPREMIUM
CARE
Non-irritant product / Dermatologist Tested Double Effect / Double System
Microfiber Sheet 3D Egg Line Care
ALCOHOL DENAT. / TALCPARABEN / DYES
MICROFIBERSHEET
3DEGG-LINE CARE
3DCERTIFIED
ANTI-WRINKLEWHITENING(1,2 STEP)
DUAL
ANTI-WRINKLEWHITENING
ALCOHOL DENAT. / TALCPARABEN / DYES
100% COTTONSHEET
CERTIFIEDDUAL
DERMATOLOGISTTESTED
Comfort F
it
Comfort F
it
Comfort Fit
NUCLEO HYDROLYZED DNA CELL POWER MASK PACK
Double functions as anti-wrinkle agent and whitening; certified by the KFDA and contains Hydrolyzed DNA. 100% cotton mask is drenched with Hydrolyzed DNA to lift the sagging skin by supplying firmness and not only whitens the skin with Niacin Amide, but also reduces the wrinkles with Adenosine.
NUCELO SKIN VITALIZING CELL POWER HAND PACKㅣ钮卡落 细胞能量手膜 Ultra-Moisturizer Hand gloves contain energizing firming factors! Transforms hand skin from rough and wrinkled to soft and firm.
EGF & PEPTIDEGives firmness and healthy glow to the skin with collagen and skin activators which exist inside the body as a kind of Amino Acid.
NUCLEO SKIN VITALIZING CELL POWER FOOT PACKㅣ钮卡落 细胞能量足膜 The Easy Foot Care peels off the thick foot dead skin cells and fills the skin with the moisturizing factors. Cleans & Firms the thick and rough foot skin to make it transparent and vital.
EGF & PEPTIDEGives firmness and healthy glow to the skin with collagen and skin activators which exist inside the body as a kind of Amino Acid.
SPECIALLY FOR DRY SKINSENSITIVE SKINATOPY SKIN
Protection of skin health with Hydrolyzed DNA
Main Ingredient
Skin troubles will be resolved only if cells are healthy. Hydrolyzed DNA makes dry or damaged skins dense and smooth. As moisturizing film is formed by double moisturizing, skin is protected and healthy skins can be maintained.
Hydrolyzed DNAActivation of skin cells Double moisturizing
Wash & Shampoo Power Softener Power Lotion Power Cream Diaper Cream D-Line Cream
Chamomile flower extractDNA-NaFormation of a moisturizing protective filmConditioning
Increase in the amount of oxygen in body Improvement on elasticity
Skin elasticity Anti-inflammatory effect
Squalene
Cell Power`s specialty given to my skin
ATO-DNA WASH & SHAMPOO _ 190ml
SpecialtyChamomile has anti-bacterial and anti-inflammatory properties for skin. Rose oil : Soothes the skin and plump the skin with soft moisture power. Bergamot oil: Soothes the irritated skin and deliver the comfort to the troubled skin.Scented geranium oil : Sebum control and abundant moisturiz-ing power
Benefits As a cleanser not only for scalp and hair but for body, it gives abundant nourishment to the hair and body so hair and body keep moisturized even after washingCleans away skin and hair wastes made from external air pollution softly without stimulation The skin feels dry and tight even after washing speedily
Paraben, Synthetic colorants, Synthetic fragrance, Methylated spirit, Mineral Oil
With a proper amount of the product, apply to wet body or scalp or hair to create a foamy lather, and rinse with water and enjoy.
ATO-DNA Power Softner _ 200ml
SpecialtyCreates double moisturizing power by delivering the rich nourishment to skin cells inside of skin, and coincidentally making skin protective barrierChamomile has anti-bacterial and anti-inflammatory properties for skin Rose oil : Sooth the skin and plump the skin with soft moisture power. Lavender has healing properties beneficial for wound skin while soothing the skin
Benefits Sooths the skin instantly with rich but fresh moisturizing power when applied.Cools and relaxes the overheated skin.Soften the rough skin texture.
Key Ingredients
No Added Ingredients
How to use
Hydrolyzed DNA , Sodium DNA, Chamomile oil, rose oil, Lavender oil
Paraben, Synthetic colorants, Synthetic fragrance, Methylated spirit, Mineral Oil
After cleansing foam, moisten a cotton pad with toner and apply evenly over the entire face. For better absorption, apply to the face in a patting motion.
ATO-DNA POWER LOTION _ 200ml
SpecialtyCreates double moisturizing power by delivering the rich nourishment to skin cells inside of skin, and coincidentally making skin protective barrier Safflower oil : Moisturizes the skin with abundant nourishment, and gives anti-oxidant propertiesOlive oil: Detoxifies the skin and gives anti-oxidant propertiesJasmine extract : Delivers the comfort to skin
Benefits Fills rich nourishment while balancing oil and water, and fresh hydration surrounding the skin completes healthy skin Relieves the dry and damaged skin and keeps the skin suppleCreates a protective skin barrier ensuring long lasting hydration.
Key Ingredients
No Added Ingredients
How to use
Hydrolyzed DNA ,Sodium DNA , Safflower oil , Olive oil, Jasmine extracts
Paraben, Synthetic colorants, Synthetic fragrance, Methylated spirit, Mineral Oil
Pump two to three times on your palm and apply evenly over your entire face, moving outwards from the center.
ATO-DNA Power Cream _ 80ml
SpecialtyCreates double moisturizing power by delivering the rich nourishment to skin cells inside of skin, and coincidentally making skin protective barrier Macadamia nuts OilIt enhances firmness containing enriched Palmitoleic acid which is efficient in strong anti-oxidant Mistletoe: Relieves the irritation while relaxing the skin Squalane: Enhances the skin protective barrierPortulaca: Gives comfort to skin while relaxing it.
Benefits Powerfully nourishing properties penetrate quickly into the skin leaving the silky texture. Leaves the skin fresh and light despite giving the rich nourish-ment.. Soothe the troubled skin instantly while providing long-lasting hydration .
Key Ingredients
No Added Ingredients
How to use
Hydrolyzed DNA , Sodium DNA,Macadamia nuts oil, Mistletoe, Squalane, Portulaca:
Paraben, Synthetic colorants, Synthetic fragrance,Methylated spirit, Mineral Oil
Take a pearl-sized amount of the cream and dot your face. Massage gently outwards to spread evenly.
ATO-DNA DIAPER CREAM _ 80ml
SpecialtyBergamot oil: Soothes the irritated skin and deliver the comfort to the troubled skinOlive oil: Detoxifies the skin and gives anti-oxidant propertiesLavender Oil : It has two effects to sterilize the skins and soothe them at the same time.
Benefits It soothes the skin trouble areas and you can feel a deep moisturizing effect.It makes delicate baby skins smooth and healthy.
When you change a baby diaper, you can gently apply and spread it out on the folded areas around the hip (hips, groin, neck, arms, legs, etc.) It would be good to sufficiently apply it on the affected skins after taking the bath.
NUCLEO D-LINE CREAM _ 200ml
SpecialtyMango Seed Butter : It delivers a sense of nutrition and a moisturizing effect of Mango seeds rich in nutrition.Shea Butter : Shea butter ingredients which had been used as medicinal ingredients in Africa mitigate skin damage.Coconut Oil : Since it is rapidly absorbed in the skins, it gives a deep moisturizing effect and promotes the absorption of other active ingredients.Macadamia Seed Oil : Since Macadamia Seed Oil has similar composition ingredients of sebum, it delivers the mitigation of skin damage and a moisturizing effect.
Benefits As it is gently absorbed after it is applied, it fills the essential energy for skin health.It prevents skin damage by soothing damaged skins such as chapped and sagging skins and giving a deep moisturizing effect.If is applied and spread out on the extremely dry skins, it softens skins and makes a smooth surface of skins.