Http://.

http://www.nrlc.org/news_and_views/April10/lorenzosoil.jpg

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Biography Full Name: Lorenzo Odone 

Born: 29th May 1978 Passed Away: 30th May 2008 

Age: 30 years of age Location: Virginia, Washington 

Country: The United States Father: Augusto 

Mother: Michaela 

Lorenzo was an intelligent and happy young boy….until  

http://images.mirror.co.uk/upl/m3/jun2008/1/4/43

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http://www

.jerrypettit.com

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One day…

Lorenzo’s behaviour drastically changed for the worse. 

http://boomeryearbook.com/blog/wp-content/uploads/2009/06/byb-temper-tantrum-cartoon.jpghttp://www.cartoonstock.com/lowres/jfa0454l.jpg

So, his parents took him to the doctor…

They then ran various tests to find out what was wrong…

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aciek/wordpress/wp-content/uploads/2

008/07/cox.jpg                                                    

http://www.saifeehospital.com/images/Facilities/46_CT_Scan.jpg

They found that… 

Lorenzo had the neurological disease Adrenoleukodystrophy (ALD).

http://www.x-ald.nl/diagnosis.htm http://www.x-ald.nl/diagnosis.htm 

http://bluefingers.files.wordpress.com/2008/03/ct-scan.jpg

ALD

http://www.nlm.nih.gov/medlineplus/ency/images/ency/fullsize/17277.jpg

http://www.x-ald.nl/carrier400.jpg

There is no transporter protein to  transport an enzyme to breakdown long chain saturated fats therefore:

Which destroys

Certain cells are made by the saturated fats, however without the enzyme to destroy  extra fat, the excess it builds up

C24

C26http://www.x-ald.nl/biochemistry.htm

http://www.x-ald.nl/biochemistry.htm

http://www.wiredtowinthemovie.com/images/hotspots/level06myelinSheath.jpg 

Losing myelin will eventually inhibit the brain's ability to control the body and the person eventually dies…

Lorenzo was given 2 years to live.

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22blind-man.jpg

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3Fq%3DDisabled%26um%3D1%26hl%3Den%26tbs%3Disch:1

Augusto and Michaela are saddened by the news of Lorenzo’s condition…

http://www.psychologytoday.com/files/u45/sad_man.jpg

In order to help Lorenzo, both Augusto and Michaela enroll Lorenzo in a clinical trial dictated by Dr. 

Nikolai…

Decrease

In

C24

C26http://www.x-ald.nl/biochemistry.htm

http://www.x-ald.nl/biochemistry.htm

https://wiki.uwc.edu/images/a/ab/Saturated-fats-picture.jpg

Michaela finds out Lorenzo had received the disease from her…

http://www.ntsad.org/images/Transmission_of_X-Linked_Traits.gif

The Clinical trial is initially is not working…

Increase of

In

C24

C26http://www.x-ald.nl/biochemistry.htm

http://www.x-ald.nl/biochemistry.htm

https://wiki.uwc.edu/images/a/ab/Saturated-fats-picture.jpg

Lorenzo is also enrolled into another clinical trial involving Cyclophosphides 

http://upload.wikimedia.org/wikipedia/commons/thumb/c/cd/Cyclophosphamide_structure.svg/481px-Cyclophosphamide_structure.svg.png

http://www.picturemosaics.com/tools/crop/display.php?n=4c0c171089317.jpg&c=your%20custom%20value

Doctors analyze Lorenzo after taking the Cyclophophide

The Desase is still  progressing however.  They observed hemianopia, with transient horizontal nystagmus. The pupillary light reflexes were still intact, as yet, there was no optic atrophy. 

http://www.yout

ube.com/watch?v

=Ey9NC18Jz2s&N

R=1

http://www.youtube.com/watch?v=Ey9NC18Jz2s&NR=1

The Odones were then contacted by Ellard Muscatine concerning the ALD foundation…

In response, they head to the ALD Family Conference in July.

http://www.youtube.com/watch?v=Ey9NC18Jz2s&NR=1

http://www.aldfoundation.org/images/index_left.jpg

At the conference, the topic of the saturated food clinical trial is brought up by Michaela…

Others were experiencing the same results as  the Odone’s were.

http://thejobsearchguru.com/notesfrom/wp-content/uploads/2009/02/rejected.jpg

http://www.youtube.com/watch?v=Ey9NC18Jz2s&feature=related

In order to understand Lorenzo’s condition better…

Through studying, Augusto described Lorenzo's condition through the use of a sink:

Tap on the right represents very long chain saturated fats. Now, also produced by the body or manufactured by the body, are these very same fats (biosynthesis). It shouldn't be problem since an enzyme breaks down the excess, however in Lorenzo’s case the enzyme is not present. In the case of the sink, the drain is blocked. 

http://etc.usf.edu/clipart/19900/19900/studying_19900_lg.gif

http://www.youtube.com/watch?v=X_IS2NL6R9E&NR=1

While at the library, Michaela had stumbled upon an article about fatty acid manipulation

In a polish study, when rats were deprived of a specific fat in their diet, body cells compensated by overproducing it. 

http://shelfelf.files.wordpress.com/2008/01/trinity-college-library-dub.jpg

So they hypothesized that they  can stop the body from producing one kind of fat:

By loading it with another:http://www.x-ald.nl/biochemistry.htm

http://www.x-ald.nl/biochemistry.htm

http://upload.wikimedia.org/wikipedia/commons/archive/f/f3/20051022203016!Question_mark_alternate.png

Reporting to Dr. Nikolai, both Augustus and Michaela wished to put together a symposium in order to 

exchange information.

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However, it was difficult to actually try and achieve this tremendous feat.

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http://blogs.discovermagazine.com/cosmicvariance/files/2008/11/time-flies-clock-10-11-2006.gif

At the symposium…

They discussed how the clinical trial was not working.

The case study was also brought up which shed a new a light on the disease.

And with the combined knowledge of researchers from all over the world…

http://www.youtube.com/watch?v=X_IS2NL6R9E&NR=1

If it is in its pure form, it becomes hazardous however if it is in its triglyceride form then it is edible.

http://upload.wikimedia.org/wikipedia/commons/archive/f/f3/20051022203016!Question_mark_alternate.png

http://1.bp.blogspot.com/_DvUbyOlnKyQ/S7IytMe8E0I/AAAAAAAAAsM/MelrpumxOTg/s1600/Caprylic+Capric+Oleic+Acids.BMP

http://www.shingleberrysigns.com/design_icon/warning%2015%20toxic.gif

In order to have oleic acid…Extraction

Of C24

And C26

From olive oil

http://www.liquid-extraction.com/images/typical-extraction.jpg

http://www.x-ald.nl/biochemistry.htm

http://www.x-ald.nl/biochemistry.htm

http://static.open.salon.com/files/how-olive-oil-works-31222748225.jpg

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http://1.bp.blogspot.com/_DvUbyOlnKyQ/S7IytMe8E0I/AAAAAAAAAsM/MelrpumxOTg/s1600/Caprylic+Capric+Oleic+Acids.BMP

The solution is there but…

Companies were being stubborn

Also, Lorenzo’s condition worsened to a point were he needed spit suctioned out of his mouth.

http://www.google.ca/images?um=1&hl=en&tbs=isch%3A1&sa=1&q=Telephone&aq=f&aqi=g10&aql=&oq=&gs_rfai=

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20080901-Rejected.gif

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

After many attempts…Protochem Laboratories

And the Odone’s were sent an extra bottle.

http://www.indiamart.com/protochem/pcat-gifs/homepage/logo.jpg

http://www.nahanniriverherbs.com/uploads/food+plants/oil_bottle.jpg

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Dr. Nikolai however warned the Odone’s about putting untested substances into Lorenzo..

Is it really ethical of the Odones to put untested substances into Lorenzo?

http://webpub.allegheny.edu/dept/psych/Pictures/Ethical.jpg

http://i243.photobucket.com/albums/ff71/death_dealer_1/Angel_of_Death.jpg

http://www.bbc.co.uk/blogs/ni/GOD2.jpg

Blood was drawn for a baseline

And then...

Lorenzo was given the oleic oil through food

http://blogs.kqed.org/bayareabites/files/2009/09/cooked-barracuda.jpg

ttp://media.photobucket.com/image/drawing%20blood%20for%20a%20baseline/mikeyismyfriend/drawing_blood.jpg

One month later…

However… Not soon after the call did Lorenzo suffer from paroxysm (saliva gets caught in the trachea.)

A small percent drop of C24 and C26 was found in Lorenzo’s blood work.

http://www.google.ca/imgres?imgurl=http://www.mdconsult.com/das/patient/body/0/0/10041/19076_en.jpg&imgrefurl=http://www.mdconsult.com/das/patient/body/0/0/10041/30160.html&usg=__OdiwFRPM7MpJEjCSWNvHOyU1Sxw=&h=320&w=400&sz=13&hl=en&start=1&sig2=NAqQDOi2vZNhSKaAqfWT7A&um=1&itbs=1&tbnid=6Spb3Kd455PzHM:&tbnh=99&tbnw=124&prev=/images%3Fq%3Dseizure%26um%3D1%26hl%3Den%26tbs%3Disch:1&ei=92sMTMaMJ4aKlwexiJyQDg

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http://www.istockphoto.com/file_thumbview_approve/8141806/2/istockphoto_8141806-bar-graph-decrease.jpg

The next update the Odone’s were given were...

50% drop in both C24 and C26 fatty acids.

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

In order to spread the good news about the Oleic acid the Odone’s had invited the Muscatine to dinner 

however…

They were being quite stubborn about accepting the Odone’s research.

http://static.open.salon.com/files/argument1227837759.jpg

http://themoderatevoice.com/wordpress-engine/files/2009_November/stubborn.jpg

In February…

The decrease in C24 and C26 fatty acids were barely noticeable..

And, as time continued, Lorenzo’s condition continually becomes worse.

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

http://www.youtube.com/watch?v=PU_3JrjZVak&feature=related

Augusto decided that he would not give up and instead, research why the oil only decreased the amount of fatty acids 

by 50%.

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In order to explain the build up of very long fatty acid chains Augusto used a paper clip analogy

Each paper clip equaled 2 carbon atoms.  These would connect to other carbon atoms in chains, such as C2-C4-C6.  These chains where trying to make monosaturated fats.  One chain was considered the "good guys" while the other  chain was considered to be the "bad guys".  The father was the "good guy enzyme" and took a carbon and put it on his chain. Deidra however was the " bad guy enzyme" and put a carbon on her chain. This was done at the same rate. However, what confused him was why when the faster the “good guys” went, the slower the “bad guys” went, if they were both separate enzymes?

http://www.youtube.com/watch?v=dLBkzlJrfLA&feature=related http://www.youtube.com/watch?v=dLBkzlJrfLA&feature=related

However, luckily for Augustus, he fell asleep and had an epiphany from a dream…

The answer that had come to him was that they were both the same enzyme. 

http://www

.youtube.com

/watch?v=d

LBkzlJrfLA&

feature=rela

ted

http://www.youtube.com/watch?v=dLBkzlJrfLA&feature=related

With this knowledge…

So if they keep the enzyme busy making monounsaturated fats, it stops the enzyme from elongating the chain.

This Process is known as Competitive Inhibition.

Erucic AcidIt explains why oleic oil was only partly successful, since it was too low down the chain. Therefore, by adding erucic acid, it creates a second barrier and blocks the “bad guys” further up the chain. 

http://en.wikipedia.org/wiki/File:Comp_inhib.svg

http://upload.wikimedia.org/wikipedia/commons/5/54/Erucic_acid.png

However…Just like the oleic acid, Dr. Nikolai was hesitant about using Erucic  acid upon Lorenzo since it causes heart problems on rats. 

Erucic acid however has to have its C24 and C26 fats removed and it is difficult to have synthesized. 

http://www.oralchelation.com/heart/images/worried.gif

http://home.comcast.net/~blake.flynn/paintings/timeconsuming.html

Through some luck however…

A British chemist known as Don Suddaby working for  Croda International decided to take on the task that the Odone’s had set.  

http://upload.wikimedia.org/wikipedia/en/3/3f/Crodalogo.PNG http://www.youtube.com/watch?v=66OKZGeLncs&feature=related

Michaela  however was having continuous problem with various nurses so she decided to call an old friend 

of Lorenzo- Omouri.Problems

http://media.photobucket.com/image/sexy%20cartoon%20Nurse/Freefreq/Nurse/images/Nurse4.jpg

http://www.youtube.com/watch?v=66OKZGeLncs&feature=related

One day…

Mr. Suddaby had managed to synthesize the erucic acid and had it delivered to the Odone’s.  

Deidra was used a test “rat” for the erucic acid. There were no harmful after effects which therefore meant it could be given to Lorenzo.

http://www.boston.com/lifestyle/food/dishing/rat.jpg

http://www.youtube.com/watch?v=66OKZGeLncs&feature=related

In September…

Lorenzo’s blood sample had come back with C24 and c25 reading normal.

http://www.nileclub.org/uploads/Eid_Celebration.jpg

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.com/blog/wp-conte

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After Lorenzo’s success

Lorenzo continued improving, even to point where he was able to swallow his own saliva.

A sample was given to  Wendy, and the same results were received with her child. This sparked a potential of a trial to be created. 

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

Lorenzo continually improved as time wore on…

With at first being able to communicate with his eyes…

and then even being able to move a finger.

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

http://www.youtube.com/watch?v=uWNvZ4dEjGU&feature=related

Meanwhile Lorenzo made it past the age of 20. He was able to move his head from side to side. He had also recovered his eyesight and had begun to vocalize simple sounds. He was learning to communicate by means of a computer.  However, on May 30, 2008 (aged 30), he died from aspiration pneumonia.

http://www.myelin.org/attachments/wysiwyg/1/LO%202002-hi.jpg