Http://cs273a.stanford.edu [Bejerano Aut07/08] 1 MW 11:00-12:15 in Redwood G19 Profs: Serafim Batzoglou, Gill Bejerano TA: Cory McLean.

http://cs273a.stanford.edu [Bejerano Aut07/08] 1

MW  11:00-12:15 in Redwood G19

Profs: Serafim Batzoglou, Gill Bejerano

TA: Cory McLean

http://cs273a.stanford.edu [Bejerano Aut07/08] 2

Lecture 13

Insulators in the Human Genome

Regulatory Potential

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Insulators: A Reminder

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CTCF

[Ohlsson et al., 2001]

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The Glass Ceiling

[Ohlsson et al., 2001]

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ChIP-chip reminder

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Breaking the Glass Ceiling

[Kim et al., 2007]

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A known locus

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More & less interesting correlations

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Outliers

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Consensus!

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Not all are captured

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From in vitro to in silico

[Xie et al., 2007]

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Predicting Distal Elements

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ChIP-Seq

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Example: NRSF

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With original motif

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Pancreatic Islet beta cell-specification GRN

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…

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