-
Biomedicine. springer.com/NEWSonline
14
F. Borruto, University of Verona, Italy; M. De Ridder,
Free University of Brussels, Belgium (Eds)
HPV and Cervical CancerAchievements in Prevention and Future
Prospects
This book is meant to provide a complete over-view of the
research of HPV and its connection to cervical cancer.
Features 7 Provides overview of HPV research from discovery
to the present day 7 Examines the process of HPV infection to
oncogenesis 7 Ex-plores the effects of HPV vaccination
Contents Preface.- The epidemiology of cervical cancer.- Human
Papillomavirus And Cervical Cancer: Overview.- Prevention of HPV
Associated Diseases in the United States.- Immunogenicity and
efficacy of, and most effective and just imple-mentation strategies
for human papillomavirus vaccines – an overview.- The Immunobiology
Of Human Papillomavirus Associated Oncogenesis.- HPV
and Therapeutic Vaccines: Where are we in 2010?.- Infection and
cervical cancer: an old fact with a recent solution.- Colposcopic
Appearance Of Hpv Infection.- Index.
Fields of interestCancer Research; Pharmacology/Toxicology
Target groupsResearch
Discount group P
Due February 2012
2012. X, 200 p. Hardcover7 approx. $189.00ISBN
978-1-4614-1987-7
9
T. J. Cleophas, A. H. Zwinderman, European
Interuniversity College Pharmaceutical Medicine, Lyon, France
Statistics Applied to Clinical StudiesContents Preface.
Foreword.-1 Hypotheses, data, strati-fication.-2 The analysis of
efficacy data.-3 The analyis of safety data.-4 Log likelihood ratio
tests for safety data analysis.-5 Equivalence testing.- 6
Statistical power and sample size.-7 Interim analyses.-8 Clinical
trials are often false positive.-9 Multiple statistical
inferences.-10 The interpretation of the p-values.-11 Research data
closer to expectation than compatible with random sampling.-12
Statistical tables for testing data closer to expectation than
compatible with random sampling.-13 Dispersion issues.-14 Linear
regression, basic approach.-15 Linear regression for assessing
precision, confounding, interaction, basic approach.-16 Curvilinear
regression.-17 Logistic and cox regression, markow models,
regression with laplace transformations.-18 Regression modeling for
improved precision.-19 Post-hoc analysis in clinical trials, a case
for logistic regression analysis.-20 Multistage regres-sion.-21
Categorical data.-22 Missing data.-23 Poisson regression for event
analysis.-24 More on non linear relationships, splines.-25
Multivariate modeling.-26 Bhattacharya modeling.-27
Trend-testing.-28 Confounding.-29 Propensity score matching.-30
Interaction.-31 Time-dependent fac-tor analysis.-32 Meta-analysis,
basic approach.-33 Meta-analysis, review and update
ofmethodolo-gies.-34 Meta-regression.-35 Crossover studies with
continuous variables.-36 Crossover studies with binary responses.
[...]
Fields of interestBiomedicine general; Laboratory Medicine;
Stati-stics, general
Target groupsResearch
Discount group P
Available
5th ed. 2012. XXVI, 743 p. 178 illus., 44 in
color. Hardcover7 approx. $239.00ISBN 978-94-007-2862-2
9
A. Destexhe, M. Rudolph-Lilith, CNRS, Gif sur Yvette,
France
Neuronal NoiseNeuronal Noise combines experimental, theoreti-cal
and computational results to show how noise is inherent to neuronal
activity, and how noise can be important for neuronal
computations.
Features 7 Neuronal Noise combines experimental,
theoretical and computational results to show how noise is inherent
to neuronal activity 7 The book covers many aspects of noise
in neurons, with an emphasis on the largest source of noise:
synaptic noise 7 Provides students and young researchers with
an overview of the important methods and concepts that have emerged
from research in this area 7 The book covers many aspects of
noise in neurons, with an emphasis on the largest source of noise:
synaptic noise 7 Provides students and young researchers with
an overview of the im-portant methods and concepts that have
emerged from research in this area 7 Provides students and
young researchers with an overview of the im-portant methods and
concepts that have emerged from research in this area
Contents 1 Introduction.- 2 Basics.- 3 Synaptic noise.- 4 Models
of synaptic noise.- 5 Integrative properties in the presence of
noise6 Recreating synaptic noise using dynamic-clamp.- 7 The
mathematics of sy-naptic noise.- 8 Analyzing synaptic noise.- 9
Case studies.- 10 Conclusions and perspectives A Nu-merical
integration of stochastic differential equa-tions.- B Distributed
Generator Algorithm.- C The Fokker-Planck formalism.- D The
RT-NEURON interface for dynamic-clamp.- References.- Index.
Fields of interestNeurosciences; Neurobiology
Target groupsResearch
Discount group P
Due January 2012
2012. XVIII, 462 p. 203 illus., 1 in color.
(Springer Series in Computational Neuroscience, Volume 8)
Hardcover7 $209.00ISBN 978-0-387-79019-0
9
www.springer.com/978-1-4614-1987-7www.springer.com/978-94-007-2862-2www.springer.com/978-0-387-79019-0
-
News 11/2011 Biomedicine.
15
K. Groschner, Karl Frazens University, Graz, Austria;
W. F. Graier, Medical University, Graz, Austria;
C. Romanin, Linz, Austria (Eds)
Store-operated Ca2+ entry (SOCE) pathwaysEmerging signaling
concepts in human (patho)physiology
Contents Preface (C. Romanin, W. F. Graier, K. Groschner).-
SECTION 1: SOCE – Fundamental mechanistic concepts.- Introduction
(J. W. Putney).- 1.1 The STIM-Orai pathway.- Structural insights
into Ca2+ sensing by stromal interaction molecules (P. B.
Stathopulos, M. Ikura).- 1.2 The STIM-Orai pathway. Orai, the
pore-forming subunit of the CRAC channel (P. G. Hogan).- 1.3 The
STIM-Orai pathway. The interactions between STIM and Orai (R.
Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin).- 1.4 STIM-TRP
pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx
complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S.
Muallem).- 1.5 STIM-TRP pathways. Function and regulation of TRPC1:
Contribution to Ca2+ entry activated by store depletion (I. S.
Ambudkar, K. T. Cheng, H. L. Ong, X. Liu).- 1.6 Microdomain
organization and the role of second messengers. Microdomain
organization of SOCE signaling (C. Moreno, L. Vaca).- 1.7
Microdomain organization and the role of second messengers.
Store-operated Ca2+ entry: Endogenous messen-gers and mediators (V.
M. Bolotina).- SECTION 2: SOCE – Crosstalk between organelle and
cellular compartments.- Introduction: Ca2+ signaling and gene
regulation: An introduction (A. B. Parekh).- 2.1 New aspects of the
contribution of ER to SOCE regulation. [...]
Fields of interestMolecular Medicine; Cell Biology; Human
Phy-siology
Target groupsResearch
Discount group P
Available
2012. XII, 500 p. 56 illus., 32 in color.
With online files/update. Hardcover7 $209.00ISBN
978-3-7091-0961-8
9
M. Hayat, Kean University, NJ, USA (Ed.)
Stem Cells and Cancer Stem Cells, Volume 4Therapeutic
Applications in Disease and Injury
Contents I. Molecular genetic.-1 Neural stem/progeni-tor cell
proliferation and differentiation: role of sonic hedgehog and
wingless/int-1 proteins.-2 Sensitivity of hematopoietic and
leukemic stem cells to hoxa gene levels.-3. Maintenance of neural
stem cells in the brain: role of notch signaling.-4 Maintenance of
hematopoiesis: role of early b cell factor 2 matthias kieslinger.-5
Differentia-tion of periodontal stem/progenitor cells: roles of
tgf-β1.-6 Induced pluripotent stem cells from human extra-embryonic
amnion cells: role of dna methylation in mainting stemness.-7
Smooth muscle cell differentiation from embryonic stem cells: role
of hdac7 and pdgf-bb.-8 Adult neural stem cells; identity and
regulation. II. Regenerative Medicine.-9 Tendon injury: role of
differentiation of aduilt and embryonic derived stem cells.-10 The
potential of stem cells and tissue engineered scaf-folds for repair
of the central nervous system.-11 Improving the efficacy of
diabetes mellitus treat-ment by combining cell replacement therapy
with immune correction.-12 Induced pluripotent stem cell
production and characterization: an overview of somatic cell
reprogramming.-13 Proliferation of bone marrow-derived human
mesenchymal stem cells: role of enamel matrix proteins.-14
Pluripo-tent cell-derived glial precursor cells for the deli-very
of therapeutic proteins to the central nervous system.-15
Cellularized scaffolds: new clothes for cardiac regenerative
medicine. [...]
Fields of interestCancer Research; Oncology; Stem Cells
Target groupsResearch
Discount group P
Available
2012. XII, 366 p. 44 illus., 32 in color.
(Stem Cells and Cancer Stem Cells, Volume 4) Hardcover7 $209.00ISBN
978-94-007-2827-1
9
M. Hayat, Kean University, NJ, USA (Ed.)
Tumors of the Central Nervous System, Volume 6Spinal Tumors
(Part 1)
Contents 1 General introduction.-2 Pediatric mixed glio-neuronal
tumors in the spinal cord.-3 Intradural spinal tumors:
classification, symptoms, and radio-logical features.-4
Non-dysraphic intradural spinal cord lipoma: management
guidelines.-5 Malignant astrocytomas of the spinal cord:
clinicopathologic parameters.-6 Spinal epidural angiolipoma. I
Di-agnosis.-7 Spinal cord tumor oligodendroglioma: diagnosis.-8
Primary spinal oligodendroglioma: diagnosis, outcome, and
prognosis.-9 Pilomyxoid astrocytoma of the spinal cord with
cerebrospinal fluid and peritoneal
metastasis.-10 Intraspinal oncocytic adrenocortical adenoma:
diagnosis.-11 Chordomas of the clivus and upper cervical spine.
Imaging.-12 Spinal teratoid/ rhabdoid tumor: use of diffusion -
weighted imaging for diagnosis.-13 Gangliogliomas of the spinal
cord: neuroimaging correlations with pathology, controversies in
pathological diagnosis, and prognosis. Therapy.-14 Surgery for
spinal tumours.-15 Resection of spinal meningioma: postoperative
focal hyperemia.-16 Spinal cord hemangioblastomas: surgical
manage-ment.-17 Spinal radiosurgery: delayed
radiation-induced myelopathy.-18 Metastatic spine disease:
indications, timing, and outcomes for surgery and radiation
therapy.-19 Sequence of surgery, radiotherapy, and stereotactic
radiosurgery in the treatment of metastatic spine disease: effects
on wound healing.-20 Treatment of spinal tumors with cyberknife
stereotactic radiotherapy.-21 Re-current spinal cord cystic
astrocytomas: treatment with rhenium-186 intracavitary radiation.
[...]
Fields of interestCancer Research; Laboratory Medicine;
Diag-nostic Radiology
Target groupsResearch
Discount group P
Available
2012. XXXII, 204 p. 64 illus., 26 in color.
(Tumors of the Central Nervous System, Volume 6) Hardcover7
$189.00ISBN 978-94-007-2865-3
9
www.springer.com/978-3-7091-0961-8www.springer.com/978-94-007-2827-1www.springer.com/978-94-007-2865-3
-
Biomedicine. springer.com/NEWSonline
16
M. v. Itzstein, Griffith University, QLD, Australia
(Ed.)
Influenza Virus Sialidase – A Drug Discovery TargetInfluenza
continues to be an ongoing problem de-spite the existence of
vaccines and drugs. Disease outbreaks can occur relatively quickly
as witnessed with the recent emergence of the influenza virus
A/H1N1 pandemic. The development of new anti-influenza drugs is
thus a major challenge. This volume describes all aspects of the
virus structure and function relevant to infection. The focus is on
drug discovery of inhibitors to the enzyme sialidase, which plays a
key role in the infectious lifecycle of the virus. Following an
overview of the influenza virus, the haemagglutinin, the
interac-tions with the cell receptors and the enzymology of virus
sialidase, recent results in drug design are presented.
Features 7 Covers all relevant aspects of anti-influenza
virus drug discovery 7 Contributions by inter-national leading
scientists 7 A valuable source of information for researchers,
clinicians and the pharmaceutical industry
Contents Influenza Virus Virology.- Investigating the
inter-action between influenza and sialic acid – making and
breaking the link.- Enzymology of Influenza Virus Sialidase.-
Influenza Virus Sialidase and Structure-Based Drug Design.- The
Development of Carbohydrate-based Influenza Virus Sialidase
Inhibitors.- The Development of Non-carbohyd-rate-based Influenza
Virus Sialidase Inhibitors.- Clinical Experience with Influenza
Virus Sialidase Inhibitors.- Resistance Development to Influenza
Virus Sialidase Inhibitors.
Fields of interestPharmacology/Toxicology; Infectious Diseases;
Virology
Target groupsResearch
Discount group P
Available
2012. IX, 178 p. 58 illus., 21 in color.
(Milestones in Drug Therapy) Hardcover7 $189.00ISBN
978-3-7643-8926-0
9
Y. Karamanos, Université d‘Artois, Arras, France (Ed.)
Expression Profiling in NeuroscienceFeatures 7 Provides the
most commonly used approaches to gene and protein expression
profiling in the field of neuroscience 7 Examines the
techniques in thorough detail in order to create lab-ready
instruction 7 Features clear-cut advice and guidance from
expert researchers in the field
Contents DNA Microarrays for Gene Expression Analysis in Brain
Tissue and Cell Lines.- Gene Expression Profiling Using the
Terminal Continuation (TC) RNA Amplification Method for Small Input
Samp-les in Neuroscience.- Expression Profiling In Brain
Disorders.- Endothelial Cell Heterogeneity of Blood-Brain Barrier
Gene Expression: Analysis by LCM/qRT-PCR.- Gene Expression
Profiling Using 3’ Digital Tag Approach.- Sharing Expression
Profiling Data with Gemma.- Two-Dimensional Protein Analysis of
Neural Stem Cells.- iTRAQ Proteomics Profiling of Regulatory
Proteins During Oligodendrocyte Differentiation.- Protein Profiling
of the Brain: Proteomics of Isolated Tis-sues and Cells.- The
Proteome of Brain Capillary Endothelial Cells: Towards a Molecular
Cha-racterization of an In Vitro Blood-Brain Barrier Model.- MALDI
Imaging Technology Application in Neurosciences: From History to
Perspectives.- Profiling of HIV Proteins in Cerebrospinal Fluid.-
Proteomic Profiling of Cerebrospinal Fluid.- New Nanotechnology
Applications in Single Cell Ana-lysis: Why and How.
Fields of interestNeurosciences; Proteomics
Target groupsProfessional/practitioner
Discount group P
Due January 2012
2012. XII, 308 p. 55 illus., 43 in color.
(Neuromethods, Volume 64) Hardcover7 $119.00ISBN
978-1-61779-447-6
9
E. Kotb, Zagazig University, Egypt
Fibrinolytic Bacterial Enzymes with Thrombolytic ActivityStress,
high blood pressure, smoking, polluti-on, fast foods, overweight,
excessive travelling, surgery, less movement are common features in
our modern life. These features are risky for blood clotting
disorders. According to WHO, over 29% of the total mortalities
worldwide are due to thrombosis. By the year, 2020 cardiovascular
di-seases (CVDs) may cause an estimated 25 million deaths per year,
thus antithrombotic therapy is of great interest. The available
thrombolytic agents such as urokinase are highly expensive,
antigenic, quite unspecific, pyretogenic and hemorrhagenic.
Therefore, the production of fibrinolysing enzy-mes, which rapidly
dissolute thrombi within the vascular tree, without the detriments
by microor-ganisms, as described in this book, is the desirable aim
of today’s research.
Features 7 Integrated practical and theoretical trends
7 Describes fibrinolytic microbial enzymes for clinical
applications 7 Provides an outlook to future research
Fields of interestMedical Microbiology; Hematology;
Cardiology
Target groupsResearch
Discount group P
Available
2012. XI, 97 p. 15 illus., 6 in color.
(SpringerBriefs in Microbiology) Softcover7 $49.95ISBN
978-3-642-24979-2
9
www.springer.com/978-3-7643-8926-0www.springer.com/978-1-61779-447-6www.springer.com/978-3-642-24979-2
-
News 11/2011 Biomedicine.
17
M. R. Kreutz, Leibniz Institute for Neurobiology,
Magdeburg, Germany; C. Sala, Consiglio Nazionale delle
Richerche, Milano, Italy (Eds)
Synaptic PlasticityDynamics, Development and Disease
Contents Preface Michael R. Kreutz, Carlo Sala.- Molecular
organization of the pre- and postsynaptic scaffold: 1. Uli Thomas,
Stephan Sigrist: Glutamate recep-tors in synaptic assembly and
plasticity – case studies on fly NMJs.- 2. Chiara Verpelli,
Michael J. Schmeisser, Carlo Sala, Tobias M. Boeckers: Scaffold
proteins at the Postsynaptic Density.- 3. Laurent Fagni: Diversity
of metabotropic glut-amate receptor interacting proteins and
patho-physiological functions.- 4. Peter Penzes, Igor Rafalovich:
Regulation of the actin cytoskeleton in dendritic spines.- 5. Olena
Bukalo, Alexander Dityatev: Synaptic cell adhesion molecules.-
Mo-lecular dynamics of the synapse: 6. Shigeo Okabe: Molecular
dynamics of excitatory synapses.- 7. Renato Frischknecht, Eckart D.
Gundelfinger: The brain‘s extracellular matrix and its role in
synaptic plasticity.- 8. Robert van den Berg, Casper C.
Hoo-genraad: Molecular motors in cargo trafficking and synapse
assembly.- 9. Martin Heine: Surface traffic in synaptic membranes.-
10. Bong-Kiun Kaang, Jun-Hyeok Choi: Synaptic protein degra-dation
in memory reorganization.- 11. Madhav Sukumaran, Andrew C. Penn,
Ingo H. Greger: AMPA receptor assembly – atomic determinants and
built-in modulators.- 12. Malgorzata Urbans-ka, Lukasz Swiech,
Jacek Jaworski: Developmental plasticity of the dendritic
compartment: focus on the cytoskeleton.- 13. Stefan Kindler,
Hans-Jürgen Kreienkamp: Dendritic mRNA targeting and translation.-
14. Mirko Santello, Corrado Calì, Paola Bezzi: Gliotransmission and
the Tripartite Synapse. [...]
Fields of interestNeurosciences; Neurology; Neurobiology
Target groupsResearch
Discount group P
Available
2012. Approx. 600 p. 120 illus., 20 in color.
(Advances in Experimental Medicine and Biology, Volume 970)
Hardcover7 $239.00ISBN 978-3-7091-0931-1
9
Z. D. Luo, University of California Irvine Medical
Center, Orange, CA, USA (Ed.)
Pain ResearchMethods and Protocols
Contents Advancements in Pain Research.- Genomic Methods for
Clinical and Translational Pain Research.- Two-Dimensional Gel
Electropho-resis: Discovering Neuropathic Pain-Associated Synaptic
Biomarkers in Spinal Cord Dorsal Horn.- Whole-Cell Patch-Clamp
Recordings on Spinal Cord Slices.- Whole-Cell Recording in Isolated
Primary Sensory Neurons.- Indwelling Supradu-ral Catheters for
Induction of Facial Allodynia: Surgical Procedures, Application of
Inflammatory Stimuli, and Behavioral Testing.- An Experimen-tal
Model of Headache-Related Pain.- A Rodent Model of Trigeminal
Neuralgia.- New Models of Experimental Parotitis and Parotid Gland
Distension in Rats.- A Rat Pain Model of Facial Cancer.- Orofacial
Pain Models and Behavior Assessment.- Unilateral T13 and L1 Dorsal
Root Avulsion: Methods for a Novel Model of Central Neuropathic
Pain.- A Lumbosacral Ventral Root Avulsion Injury and Repair Model
for Studies of Neuropathic Pain in Rats.- A Rat Chronic Pain Model
of Spinal Cord Contusion Injury.- The Spared Nerve Injury Model of
Neuropathic Pain.- A New Rat Pain Model of Thrombus-Induced
Ischemia.- Rat Models of Pancreatitis Pain.- The Monosodium
Iodoacetate Model of Osteoarthritis Pain in The Rat.- K/BxN Serum
Transfer Arthritis as a Model of Inflammatory Joint Pain.- A New
Rat Model of Bone Cancer Pain.- Exposure of the Dorsal Root
Ganglion to Pulsed Radiofrequency Current in a Neuropathic Pain
Model of Periphe-ral Nerve Injury.
Fields of interestMolecular Medicine; Pain Medicine
Target groupsProfessional/practitioner
Discount group P
Due January 2012
2nded. 2012. XIX, 306 p. 66 illus., 4 in
color. (Methods in Molecular Biology, Volume 851)
Hardcover7 approx. $119.00ISBN 978-1-61779-560-2
9
A. Morozov, National Institutes of Health, Bethesda, MD,
USA (Ed.)
Controlled Genetic ManipulationsThe current demand for the
development of techniques for controlled genetic manipulations is
driven by the anatomical and physiological complexity of the brain
and by the need for expe-rimental models that can address this
complexity through selective manipulation of defined compo-nents of
the system: specific neuronal populations or selected synapses.
Features 7 Provides both basic technical information and
examples of creative implementation 7 Supplies readers with
the details needed to bring these techniques to their own labs
7 Features key tips from the experts on how best to avoid
common pitfalls
Contents Regulation of Cre Recombinase: Use of Ligand-Regulated
and Dimerizable Cre for Transgenesis.- Genetic Manipulations Using
Cre and Mutant loxP Sites.- Using Recombinant Adeno-Associated
Viral Vectors for Gene Expression in the Brain.- Using Lentiviral
Vectors as Delivery Vehicles for Gene Therapy.- Targeting
Neurological Disease with siRNA.- In Utero Electroporation for
Cellular Transgenesis in the Developing Mammalian Forebrain.-
Single-Cell Electroporation of siRNA in Primary Neuronal Cultures.-
Development and Application of Membrane-Tethered Toxins for Genetic
Analyses of Neuronal Circuits.- Genetic Methods for Anatomical
Analysis of Neuronal Circuits.- Functional Circuitry Analysis in
Ro-dents Using Neurotoxins/Immunotoxins.- Analy-sis of Neuronal
Circuits with Optogenetics.
Fields of interestNeurosciences; Human Genetics
Target groupsProfessional/practitioner
Discount group P
Due January 2012
2012. XIII, 296 p. 47 illus., 27 in color.
(Neuromethods, Volume 65) Hardcover7 $119.00ISBN
978-1-61779-532-9
9
www.springer.com/978-3-7091-0931-1www.springer.com/978-1-61779-560-2www.springer.com/978-1-61779-532-9
-
Biomedicine. springer.com/NEWSonline
18
J. Peccoud, Virginia Bioinformatics Institute, Blacksburg,
VA, USA (Ed.)
Gene SynthesisMethods and Protocols
Contents Building Block Synthesis using the Polymerase Chain
Assembly (PCA) Method.-Oligonucleotide Assembly in Yeast to Produce
Synthetic DNA Fragments.-TopDown Real-Time Gene Synthesis.-De novo
DNA Synthesis using Single-molecule PCR.-SLIC: A Method for
Sequence and Ligation Independent Cloning.-Assembly of Standardized
DNA Parts Using BioBrick Ends in E. coli.-Assembling DNA Fragments
by USER Fusion.-Fusion PCR via Novel Overlap Sequences.-Using
Recombineering to Generate Point Mutations: the
Oligonucleotide-based “Hit &Fix” Method.-Using Recombineering
to Generate Point Mutations: galK-Based Positive-Negative Selection
Method.-Assembling Large DNA Segments in Yeast.-Recursive
Construction of Perfect DNA Molecules and Libraries from Imperfect
Oligonucleotides.-Cloning Whole Bacterial Genomes in
Yeast.-Production of Infectious Poliovirus from Synthetic Viral
Genomes.-In Silico Design of Functional DNA Constructs.-Using
DNAWorks in Designing Oligonucleotides for PCR-Based Gene
Synthesis.-De Novo Gene Synthesis Design Using TmPrime
Software.-Design-A-Gene with GeneDesign.-Leading a Successful iGEM
Team .-The Build-a-Genome Course.-DNA Synthesis Security.
Fields of interestHuman Genetics; Genetic Engineering
Target groupsProfessional/practitioner
Discount group P
Due February 2012
2012. XV, 320 p. 77 illus., 42 in color.
(Methods in Molecular Biology, Volume 852) Hardcover7 $139.00ISBN
978-1-61779-563-3
9
D. W. Pfaff, Rockefeller University, New York, NY, USA
(Ed.)
Neuroscience in the 21st CenturyBasic and Clinical
Contents BASIC.- Biophysics.- Development.- Neuroanato-my, Cell,
Biology.- Sensory Systems (neuroanato-my and physiology).- Motor
Control (neuroanato-my and physiology).- Neurophysiology of
specific CNS regions.- Neurochemistry, Neuropharmaco-logy.-
Neuroendocrinology.- Regulation of natural behaviors.- Cognitive
Neuroscience.- Computati-onal neuroscience.- CLINICAL.-
Developmental disorders.- Pain.- Neuroimmune disorders.- Ad-dictive
disorders.- Degenerative diseases.- Gender identity issues.-
Psychiatric disorders.<
Fields of interestNeurosciences; Neurobiology; Neurology
Target groupsResearch
Discount group P
Due August 2012
Print
2012. 1200 p. (In 2 volumes, not available separately)
7 $679.00ISBN 978-1-4614-1996-9
9 eReference
2012. 7 $679.00ISBN 978-1-4614-1997-6
9 Print + eReference
2012. 1200 p. (In 2 volumes, not available separately)7
$849.00ISBN 978-1-4614-1998-3
9
A. Prokop, Vanderbilt University, Nashville, TN, USA;
S. Michelson, Genomic Health Inc, Redwood, CA, USA
Systems Biology in Biotech & PharmaA Changing Paradigm
Features 7 Numerous step-by-step tutorials help the reader
to learn quickly 7 Outline of key tech-nologies and tools
needed for the development of Systems Biology 7 Computational
Systems Bio-logy in Health and Disease 7 The use of Systems
Biology for identifying drug targets
Contents Abstract.- 1 Introduction: Discovery & Deve-lopment
- New Facet Of Industry, New Tools And Lead Optimization: 1.1 Scope
And Content Of This Review.- 2 Discovery: Use Of Systems Biology
For Identifying Targets.- 3 Integrative Systems Biology I -
Biochemistry: Phase I Lead Discovery & Molecular
Interactions.- 4 Integ-rative Systems Biology Ii - Molecular
Biology: Phase 2 Lead Discovery & In Silico Screening.-
5. Discovery: Computational Systems Biology (Csb) In Health &
And Disease I.- 6 Development: In Vivo Pharmacology - Systems
Biology In Health & Disease Ii.- 7 Development:
Pharmacokinetics – Systems Biology In Health & Disease Iii.- 8
De-velopment: Multiscale Csb – Simulation Tools.- 9
Development: Drug Formulation & Delivery.- 10
Development: Preclinical Model Based Drug Development.- 11 Systems
Biology: Impact On Pharma And Biotech.- 12 Acknowledgment.- 13
Bibliography.
Fields of interestBiomedicine general; Biotechnology; Applied
Microbiology
Target groupsResearch
Discount group P
Available
2012. XVI, 133 p. 16 illus. in color.
(SpringerBriefs in Pharmaceutical Science & Drug Development,
Volume) Softcover7 $49.95ISBN 978-94-007-2848-6
9
www.springer.com/978-1-61779-563-3www.springer.com/978-1-4614-1996-9www.springer.com/978-1-4614-1997-6www.springer.com/978-1-4614-1998-3www.springer.com/978-94-007-2848-6
-
News 11/2011 Biomedicine.
19
F. Rahimi, Australian National University, Canberra, ACT,
Australia; G. Bitan, University of California at Los Angeles,
CA, USA (Eds)
Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative DiseasesContents
1. Overview of Fibrillar and Oligomeric Assem-blies of
Amyloidogenic Proteins.- 2. Pathologic Lesions in Alzheimer disease
and Other Neuro-degenerative Diseases—Cellular and Molecular
Components.- 3. Preparation and Structural Cha-racterization of
Pre-fibrillar Assemblies of Amylo-idogenic Proteins.- 4. Biological
Targeting and Ac-tivity of Pre-fibrillar Aβ Assemblies.- 5. The
Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s
disease.- 6. Oligomers of α-Synuclein in the Pathogenesis of
Parkinson’s Disease.- 7. Cytotoxic Mechanisms of Islet Amyloid
Polypepti-de in the Pathogenesis of Type-2 Diabetes Mellitus
(T2DM).- 8. Protein Misfolding and Toxicity in Amyotrophic Lateral
Sclerosis.- 9. Structural Studies of Prion Proteins and Prions.-
10. Role of Prion Protein Oligomers in the Pathogenesis of
Transmissible Spongiform Encephalopathies.- 11. When More Is Not
Better: Expanded Polyglutami-ne Domains in Neurodegenerative
Disease.- 12. Protein Misfolding and Toxicity in Dialysis-Rela-ted
Amyloidosis.- 13. Transthyretin Aggregation and Toxicity.- 14.
Strategies for Inhibiting Protein Aggregation: Therapeutic
Approaches to Protein-Aggregation Diseases.
Fields of interestBiomedicine general; Protein Science; Protein
Structure
Target groupsResearch
Discount group P
Available
2012. XVII, 593 p. 81 illus., 37 in color.
Hardcover7 $209.00ISBN 978-94-007-2773-1
9
T. Rőszer, Spanish National Cardiovascular Research Center,
Madrid, Spain
The Biology of Subcellular Nitric OxideThis book fills in a gap
in the NO literature.
Features 7 Fills a gap in NO biology-related litera-ture
7 Topics discussed have general biological relevance
Interdisciplinary summary on recent advance on NO cellular biology
7 Chapter summaries and illustrations help rapid
understan-ding of complex interactions 7 Can be used as a
reference in scientific papers 7 Can be used as a lecture
book
Contents Foreword.- Preface.- Part I General Concepts.-
Introduction Part II Nitric Oxide Synthesis in Prokaryote
Cells.- 2 Nitric Oxide is a Bioproduct In Prokaryotes.- Part
III Nitric Oxide Synthesis in Plant Organelles.- 3 Nitric Oxide
Synthesis in the Chloroplast.- 4 NO Synthesis in Leaf Peroxisomes
And Plant-Type Mitochondria.- Part IV At the Edge of the Plant and
Animal Kingdom.- 5 NO Synthesis iIn Subcellular Compartments of
Fungi.- Part V Nitric Oxide Synthesis in Animal Cells.- 6 Harboring
of NOS to the Cell Membrane.- 7 The Golgi System Contributes to NO
Homeostasis.- 8 Phagosomal And Lysosomal NO Synthesis.- 9 NO
Synthesis and Cell Locomotion.- 10 Nitric Oxide Synthesis in the
Mitochondria of Animal Cells.- 11 Peroxisomes: Where NOS Rests In
Peace?.- 12 Subcellular Redistribution of NOS.- Appendix.-
Abbreviations.- Glossary.- Image Information.- Subject Index.
Fields of interestBiomedicine general; Molecular Medicine; Cell
Biology
Target groupsResearch
Discount group P
Available
2012. I, 299 p. 63 illus., 14 in color.
Hardcover7 $189.00ISBN 978-94-007-2818-9
9
P. Salvi, University of Nancy, France
Pulse WavesHemodynamic approach to explain blood pressure
values
Recently, several studies have shown the crucial role of
viscoelastic properties of the aorta and lar-ge arteries in
determining blood pressure values. A good knowledge of
cardiovascular pathophysio-logy and vascular hemodynamics is
necessary to understand these phenomena. However, available texts
on this topic are very complex and difficult for medical
practitioners to understand. The aim of this book is to enable the
reader to comprehend the relation between cardiovascular
pathophysio-logy and vascular hemodynamics and to become familiar
with the more recent guidelines. While very complex physical
concepts are involved, care has been taken to ensure that the
explanations are as straightforward as possible. Complex analyses
are presented separately and can be skipped by the reader without
impairment of understanding. It is envisaged that the knowledge
imparted will prove invaluable in improving the approach to
hyperten-sive patients.
Features 7 Straightforward presentation of very complex
physical concepts 7 Many figures and user-friendly language,
ensuring that the text is readily intelligible 7 Separate
presentation of complex analyses in boxes, allowing them to be
skipped without impairment of understanding
Contents Introduction.- Mean arterial pressure.- Pulse
Pressure.- Central blood pressure.- Appendix.- References.
Fields of interestHuman Physiology; Cardiology
Target groupsProfessional/practitioner
Discount group P
Available
2012. X, 100 p. 70 illus. Softcover7 approx.
$69.95ISBN 978-88-470-2438-0
9
www.springer.com/978-94-007-2773-1www.springer.com/978-94-007-2818-9www.springer.com/978-88-470-2438-0
-
Biomedicine. springer.com/NEWSonline
20
F. H. Sarkar, Wayne State University, Detroit, MI, USA
(Ed.)
Nutraceuticals and CancerFeatures 7 Neutraceuticals and
Cancer Therapy 7 Targe-ted and Adjuvant Therapy
7 Approach reducing systemic toxicity
Contents Preface.-1. Global Overview of the Role of
Nutra-ceuticals in Cancer.-2. Cancer Stem Cells: Novel Target Using
Dietary Components for Prevention and Treatment.-3. Polyphenols as
Receptor Tyro-sine Kinase Inhibitors and Anti-Cancer Agents.-4.
Role of Nutraceuticals on Nrf2 and Its Implication in Cancer
Prevention.-5. Current Status and Fu-ture Prospects of
Nutraceuticals in Prostate Can-cer.-6. Cellular, Molecular and
Biological Insight Into Chemopreventive and Therapeutic Potential
Of 3, 3’-Diindolylmethane (Dim).-7. Mechanism of Action of the
Anti-Cancer Agent, Triptolide.-8. Nutraceuticals in Human Urinary
Bladder Cancer Prevention andTreatment.-9. Exploiting resve-ratrol
for the treatment of cancer.-10. Role of novel nutraceuticals
garcinol, plumbagin and mangiferin in the prevention and therapy of
human malig-nancies: mechanisms of anticancer activity.-11.
Anthocyanins and Cancer Prevention.-12. Slow but Steady Progress in
Cancer Chemoprevention with Phenethyl isothiocyanate: Fulfilled
Promises and Translational Challenges.-13. Skin cancer
chemoprevention: Current status and future po-tential.-14. Dietary
Phytochemicals and Chemo-prevention of Solar Ultraviolet
Radiation-Induced Skin Cancer.-15. The Role of Vitamin E Forms in
Cancer Prevention and Therapy – Studies in Hu-man Intervention
Trials and Animal Models.-16. Augmenting the efficacy of chemo- and
radio-the-rapy by nutraceuticals: Evidence from pre-clinical and
clinical trials. Index.
Fields of interestBiomedicine general; Cancer Research;
Nutrition
Target groupsResearch
Discount group P
Available
2012. VI, 398 p. 19 illus. in color. Hardcover7
$209.00ISBN 978-94-007-2629-1
9
B. Shapiro, The Pennsylvania State University, University
Park, PA, USA; M. Hofreiter, University of York, UK (Eds)
Ancient DNAMethods and Protocols
Contents Setting Up An Ancient DNA Laboratory.-A
Phenol-Chloroform Protocol for Extracting DNA from Ancient
Samples.-DNA Extraction of Anci-ent Animal Hard Tissue Samples via
Adsorption to Silica Particles.- Case Study: Recovery of ancient
nuclear DNA from Toe Pads of the Extinct Passen-ger
Pigeon.-Extraction of DNA from Paleofeces.-DNA Extraction from
Keratin and Chitin.-Case Study: Ancient sloth DNA Recovered
from Hairs Preserved in Paleofeces.-Ancient DNA Extraction from
Soils and Sediments.-DNA Extraction from Fossil Eggshell.-Ancient
DNA Extraction from Plants.-DNA Extraction from Formalin-fixed
Material.-Case Study: Ancient DNA recovered from Pleistocene-age
Remains of a Florida Armadillo.-Non-destructive DNA Extraction from
Museum Specimens.-Case Study: Using a Non-destructive DNA
Extraction Method to Generate mtDNA Sequences from Historical
Chimpanzee Specimens .-PCR Amplification, Cloning and Sequencing of
Ancient DNA.-Quantitative Real-time PCR in aDNA Research.-Multiplex
PCR Amplification of Ancient DNA.-Preparation of Next-generation
Sequencing Libraries from Da-maged DNA.-Generating Barcoded
Libraries for Multiplex High-throughput Sequencing.-Case Stu-dy:
Targeted high-throughput Sequencing of Mi-tochondrial Genomes from
Extinct Cave Bears via Direct Multiplex PCR Sequencing
(DMPS).-Target Enrichment via DNA Hybridization Capture.-Case
Study: Enrichment of Ancient Mitochondrial DNA by Hybridization
Capture.-Analysis of High-throughput Ancient DNA Sequencing Data.
[...]
Fields of interestHuman Genetics
Target groupsProfessional/practitioner
Discount group P
Due February 2012
2012. XV, 282 p. 23 illus., 12 in color.
(Methods in Molecular Biology, Volume 840) Hardcover7 $119.00ISBN
978-1-61779-515-2
9
S. D. Skaper, University of Padova, Italy (Ed.)
Neurotrophic FactorsMethods and Protocols
Contents The Neurotrophin Family of Neurotrophic Factors – An
Overview.- Neuronal Growth-Promoting and Inhibiting Cues in
Neuroprotection and Neu-rodegeneration.- Culture of Rat Cerebellar
Granu-le Neurons and Application to Identify Neuropro-tective
Agents.- Isolation and Culture of Neural Progenitor Cells from Rat
Postnatal Cerebellum.- Culture of Rodent Cortical and Hippocampal
Neurons.- Amyloid β-Peptide Neurotoxicity Assay Using Cultured Rat
Cortical Neurons.- Culture of Neonatal Rodent Microglia,
Astrocytes, and Oligodendrocytes from Cortex and Spinal Cord.-
Central Nervous System Neuron-Glia Co-Culture Models.- Culture and
Characterization of Rat Mesencephalic Dopaminergic Neurons.-
Prepara-tion of Adult Spinal Cord Motor Neuron Cultures Under
Serum-Free Conditions.- Rodent Retinal Ganglion Cell Cultures.-
Culture of Purified Glial Cell Populations from Optic Nerve.-
Isolation and Culture of Rat Cone Photoreceptor Cells.- Rat Retina
Pigmented Epithelial Cells.- Mammalian Growth Cone Turning Assays
Identify Distinct Cell Signalling Mechanisms that Underlie Axon
Growth, Guidance and Regeneration.- Culture of Dissociated Sensory
Neurons from Dorsal Root Ganglia of Postnatal and Adult Rats.-
Culture and Proliferation of Highly Purified Adult Schwann Cells
from Rat, Dog, and Man.- Use of PC12 Cells and Rat Superior
Cervical Ganglion Sympathetic Neurons as Models for Neuroprotective
Assays Relevant to Parkinson’s Disease.- Compartmen-ted Chambers
for Studying Neurotrophic Factor Action.- Preparation and Culture
of Adrenal Chromaffin Cells.- Indirect Immunofluorescence Staining
of Cultured Neural Cells. [...]
Fields of interestNeurosciences; Neurobiology;
Neurochemistry
Target groupsProfessional/practitioner
Discount group P
Due January 2012
2012. XV, 474 p. 69 illus., 26 in color.
(Methods in Molecular Biology, Volume 846) Hardcover7 $139.00ISBN
978-1-61779-535-0
9
www.springer.com/978-94-007-2629-1www.springer.com/978-1-61779-515-2www.springer.com/978-1-61779-535-0
-
News 11/2011 Biomedicine.
21
R. Srivastava, S. Shankar, University of Kansas
Medical Center, Kansas City, KS, USA (Eds)
Stem Cells and Human DiseasesContents 1. Cancer Stem Cells:
Biology, Perspectives and Therapeutic Implications.- 2. The
Perspectives of Stem Cell-based Therapy in Neurological Disea-ses.-
3. Stem Cell-based Therapy for Lysosomal Storage Diseases.- 4.
Drosophila germline stem cells.- 5. Mesenchymal Stem Cells in
Hematopoi-etic Stem Cell Transplantation.- 6. Cancer Stem Cells in
Solid Tumors, Markers and Therapy.- 7. Cancer Stem Cells: Paradigm
Shifting or Perishing Concept.- 8. Genomics of Prostate Cancer.- 9.
Ischemia, reactive radicals, redox signaling and hematopoietic stem
cells.- 10. Cancer stem cell models and role in drug discovery.-
11. Origins of Metastasis-Initiating Cells.- 12. The Reduction of
Callus Formation during Bone Regeneration by BMP-2 and Human
Adipose Derived Stem Cells.- 13. Stem cells and leukemia.- 14. The
role of adult bone marrow derived mesenchymal stem cells, growth
factors and scaffolds in the repair of cartilage and bone.- 15.
Worth the Weight: Adi-pose Stem Cells in Human Disease.- 16. Neural
crest and Hirschsprung’s disease.- 17. Common denominators of
self-renewal and malignancy IN neural stem cells and GLIOMA.- 18.
Stem-like cells from brain tumours or vice versa?.- 19. Translating
Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics.- 20.
Breast Cancer Stem Cells.- 21. Translin/TRAX deficiency
affects mesenchymal differentiation programs and in-duces bone
marrow failure.- 22. Cancer therapies and Stem cells.- 23. Cancer
Stem Cells and Head and Neck Squamous Cell Carcinomas.- 24. The
Biology of Lung Cancer Stem Cells. [...]
Fields of interestBiomedicine general; Literacy; Medicine/Public
Health, general
Target groupsResearch
Discount group P
Available
2012. DCCXIII, 13 p. 64 illus., 52 in color.
Hardcover7 $279.00ISBN 978-94-007-2800-4
9
H. M. Staines, S. Krishna, University of London,
UK (Eds)
Treatment and Prevention of MalariaAntimalarial Drug Chemistry,
Action and Use
Features 7 Gives a comprehensive account of the recent
advances in anti-malaria drugs 7 Chapters contributed by
expert authors 7 Describes new ideas and directions for
study
Contents Antimalarial drugs and the control and eliminati-on of
malaria.- 4-Aminoquinolines: chloroquine, amodiaquine and next
generation analogues.- Cinchona alkaloids: quinine and quinidine.-
8-Aminoquinolines: primaquine and tafenoqui-ne.- Other
4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine,
lumefantrine, halofantrine, piperaquine and pyronaridine.-
An-tifolates: pyrimethamine, proguanil, sulphadoxine and dapsone.-
Naphthoquinones: atovaquone, and other antimalarials targeting
mitochondrial func-tions.- Non-antifolate antibiotics: clindamycin,
doxycycline, azithromycin and fosmidomycin.- Artemisinins:
artemisinin, dihydroartemisinin, artemether, arteether and
artesunate.- Second generation peroxides: the OZs and artemiso-ne.-
Combination therapy in light of emerging artemisinin resistance.-
New medicines to combat malaria: an overview of the global pipeline
of therapeutics.- Molecular markers of Plasmodium resistance to
antimalarials.- Prevention of mala-ria.- Malaria diagnostics:
lighting the path.
Fields of interestPharmacology/Toxicology; Infectious Diseases;
Parasitology
Target groupsResearch
Discount group P
Available
2011. XX, 260 p. 57 illus., 15 in color.
(Milestones in Drug Therapy) Hardcover7 $189.00ISBN
978-3-0346-0479-6
9
L. W. Tari, Trius Therapeutics, San Diego, CA, USA
(Ed.)
Structure-Based Drug DiscoveryThe last decade has seen the
confluence of several enabling technologies that have allowed
protein crystallographic methods to live up to their true
potential.
Features 7 Includes cutting-edge methods and proto-cols
7 Provides step-by-step detail essential for reproducible
results 7 Contains key notes and implementation advice from
the experts
Contents The Utility of Structural Biology in Drug Discove-ry.-
Genetic Construct Design and Recombinant Protein Expression for
Structural Biology.- Puri-fication of Proteins for Crystallographic
Applica-tions.- Protein Crystallization for Structure-Based Drug
Design.- X-Ray Sources and High-Throughput Data Collection
Methods.- The Use of Molecular Graphics in Structure-Based Drug
De-sign.- Crystallographic Fragment Screening.- The Role of
Enzymology in a Structure-Based Drug Discovery Program: Bacterial
DNA Gyrase.- Leve-raging Structural Information for the Discovery
of New Drugs: Computational Methods.- Chemical Informatics – Using
Molecular Shape Descriptors in Structure-Based Drug Design.-
Accounting for Solvent in Structure-Based Drug Design.-
Struc-ture-Based Drug Design on Membrane Protein Targets: Human
Integral Membrane Protein 5-Lipoxygenase-Activating Protein.-
Application of SBDD to the Discovery of New Antibacterial Drugs.-
Leveraging SBDD in Protein Therapeutic Development: Antibody
Engineering.- A Medi-cinal Chemistry Perspective on Structure-Based
Drug Design and Development.
Fields of interestPharmacology/Toxicology; Medicinal
Chemistry
Target groupsProfessional/practitioner
Discount group P
Due January 2012
2012. X, 454 p. 129 illus., 17 in color.
(Methods in Molecular Biology, Volume 841) Hardcover7 $139.00ISBN
978-1-61779-519-0
9
www.springer.com/978-94-007-2800-4www.springer.com/978-3-0346-0479-6www.springer.com/978-1-61779-519-0
-
Biomedicine. springer.com/NEWSonline
22
A. Thiel, Berlin-Brandenburg Center for Regenerative
Therapies (BCRT), Berlin, Germany (Ed.)
ImmunosenescenceAs individuals age, their ability to respond to
and clear pathogens and to control unwanted immune reactions
declines, leading to a greater incidence of certain infectious
diseases, autoim-munity and general immune dysfunctions. Most
remarkably, the efficacy of vaccines is frequently decreased in
elderly persons. Therefore, age-as-sociated dysfunctions of the
humoral and cellular immune responses have a strong clinical
impact. Improving our understanding of the aged immune system is
crucial in developing effective preven-tion and treatment programs
that will facilitate healthy aging and improve the quality of life
of the elderly population.
Features 7 Describes molecular aspects of the aging immune
system 7 Discusses new therapeutic approaches 7 Written
by internationally reputed scientists
Contents Regulation of Adaptive Immunity in the Elder-ly.- Does
Innate Immunity Get Old?.- Thy(-Im)Munosenescence: The Ageing of
the Thymus and Its Impact on the Immune System.- Characte-ristics
of B Cells and B Cell Responses in Aged Individuals.- Mechanisms of
Immune Protection to Pneumococcal Infection in the Young and the
Elderly.- CMV Subversion of the Immune System in Later Life.- Aging
and Autoimmunity.- Vacci-nation in the Elderly.- Immunosenescence
and the 3r’s; Restoration, Replacement and Reprogram-ming.- Novel
Strategies of Improved Vaccines for Elderly: The Example of
Influenza.
Fields of interestBiomedicine general; Immunology; Molecular
Medicine
Target groupsProfessional/practitioner
Discount group P
Available
2012. XX, 225 p. 4 illus., 3 in color.
(Birkhäuser Advances in Infectious Diseases) Hardcover7 $189.00ISBN
978-3-0346-0218-1
9
H. G. Vogel, J. Maas, Aventis Pharma, Frankfurt,
Germany; F. J. Hock, Dieburg, Germany; D. Mayer,
Idstein, Germany (Eds)
Drug Discovery and Evaluation: Safety and Pharmacokinetic AssaysFeatures
7 A landmark in the continuously changing world of drugs
7 Essential reading for scientists and managers in the
pharmaceutical industry in-volved in drug finding, drug development
and de-cision making in the development process 7 Of use for
government institutions and committees working on official
guidelines for drug evaluation worldwide
Contents From the contents: General Introduction: Safety
Pharmacology.- Safety Pharmacokinetics.- Safety Toxicology.
Fields of interestPharmacology/Toxicology
Target groupsResearch
Discount group P
Available
Print
2nd Edition. 2012. 1000 p. (In 2 volumes, not
available separately) 7 approx. $679.00ISBN
978-3-642-25239-6
9 eReference
2nd Edition. 2012. 7 approx. $679.00ISBN
978-3-642-25240-2
9 Print + eReference
2nd Edition. 2012. 1000 p. (In 2 volumes, not available
separately) 7 approx. $849.00ISBN 978-3-642-25241-9
9
www.springer.com/978-3-0346-0218-1www.springer.com/978-3-642-25239-6www.springer.com/978-3-642-25240-2www.springer.com/978-3-642-25241-9