HP Labs Escondido, CA Methanol and Ethanol Analysis/ J. Picker The Ultimate Gourmet Martini.

HP Labs Escondido, CA

Methanol and Ethanol Analysis/

J. Picker

The Ultimate Gourmet Martini

HP Labs Escondido, CA

Objective Analyze methanol and ethanol

at 100-1000 ug/L or lower Use standard or modified EPA

Methods Provide adequate Turnaround

and pricing to meet client needs

Make a profit

HP Labs Escondido, CA

Warning Methanol is “wood alcohol”

minimum lethal dose 1g/kg but toxic effects as low as 10g.

toxicity is due to metabolic production of formic acid

Ethanol is less toxic

HP Labs Escondido, CA

Problems Very Poor purging efficiency (i.e.,

NO 5030/5035) Allowed Prep. Techniques

5031 Azeotropic distillation 5032 Vacuum distillation 5021 Equilibrium Headspace =nd 5041 VOST train = nd Direct Inject

HP Labs Escondido, CA

Problems II Low sensitivity on FID and

MS Interferences by HCs and

other compounds on FID

HP Labs Escondido, CA

HP Labs’ Solution Direct Aqueous injection/EPA

Method 8260B GC Column and conditions to

separate MeOH, EtOH from water Stable Labeled isotope internal

standards (CD3OH,CD3CH2OH) Modified with Selected Ion

Monitoring Mass Spectrometry (SIM)

HP Labs Escondido, CA

HP Labs Escondido, CA

HP Labs Escondido, CA

HP Labs Escondido, CA

HP Labs Escondido, CA

Sample Preparation: water Sample Size 1 mL Add Labeled IS Solution Inject

HP Labs Escondido, CA

Sample Preparation: Soil Ultrasonic extraction (EPA 3550)

10 g/10 mL Remove 1mL Add IS Inject

HP Labs Escondido, CA

Detection Limits Water and Soil

MDLs < 100 ug/L (ug/kg) EQLs 250 ug/L (ug/kg)

HP Labs Escondido, CA

What This Means

Methanol and Ethanol on site or off site

Rapid turnaround All levels of QC Price as low as fixed base