How can I disable McAfee Total Protection? McAfee antivirus takes care of your device and there are some instances when it can be moved protective and starts blocking programs. Those programs are trustworthy and you need them but in case, if you aren’t able to open it because of McAfee then, the only fix left behind is to disable it. Table Of Content: McAfee Total Protection Disabling procedure in Windows Steps to disable McAfee Total Protection in macOS Things to keep in mind after disabling McAfee McAfee Total Protection Disabling Procedure In Windows If you are stuck because McAfee is troubling you by blocking a trusted program or app then, all you need to do is to disable McAfee Antivirus from Windows PC.