HLA-B57 does not fully explain the ability of HIV controllers to clear HCV infection Alice K. Asher 1 , RN, MS; Glenn-Milo Santos 1 , MPH; Jennifer Evans, MS 1 ; E. Kainne Dokubo 1 , MD; Jeff Martin 1 , MD; Steve Deeks 1 , MD; MPH; Leslie Tobler 2 , Dr.Ph; Mike Busch 2 , MD, Ph.D.; Peter Hunt 1 , MD; Kimberly Page 1 , PhD, MPH 1 University of California, San Francisco 2 Blood Systems Research Institute, San Francisco, California
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HLA-B57 does not fully explain the ability of HIV controllers to clear HCV infection
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HLA-B57 does not fully explain the ability of HIV controllers to clear HCV infection
Alice K. Asher1, RN, MS; Glenn-Milo Santos1, MPH; Jennifer Evans, MS1; E. Kainne Dokubo1, MD; Jeff Martin1, MD; Steve Deeks1, MD; MPH; Leslie Tobler2, Dr.Ph; Mike Busch2, MD, Ph.D.; Peter Hunt1, MD; Kimberly Page1, PhD, MPH 1University of California, San Francisco2Blood Systems Research Institute, San Francisco, California
Spontaneous clearance of HCV
• 20-25% of HCV infected persons spontaneously clear the virus
• HIV co-infected: 10-20%• Factors associated with
spontaneous HCV clearance:– Sex (Micallef, et al., 2007; Page, et al., 2009)– IL-28B status (Thomas, et al., 2009)– HLA type (Thio, et al., 2002; Kim, et al., 2011)– T cell response (Osburn, et al., 2010)
• Micallef, 2007, J. Viral Hepatitis; Matthews, 2008, Gasterenterol Hepatol
HIV control in the absence of ART
• 1-5% of PLWHA are considered ‘HIV controllers’• Elite controllers: anti-HIV positive; no
measurable HIV viremia (<75 copies/mL)• Viremic controllers: anti-HIV positive;
measurable low level viremia (75-2000 copies/mL)
• HIV controllers are more likely to spontaneously clear HCV