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By:Hartini Sri Utami (011314653010)Ririn Ratnasari (011314653003)
HLA and NK Cell In Pregnancy
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1. Agi Harliani S. 2010. Human Leucocyte-G (HLA-G)Dan Peranannya Dalam Reproduksi. MajalahKesehatan Pharma Medika Vol. 2 No. 1
2. Ashley Moffett-King. 2002. Natural Killer Cells AndPregnancy. Nature Rieviews Immunology Vol 2.Nature Publishing group
3. E. Albert Reece, John C. Hobbins, John Wiley &
Sons. 2008. Clinical Obstetrics: The Fetus AndMother. Oxford UK: Blackwell Publishing4. Joan S. Hunt, Margaret g. Petroff, Remsey H.
McIntire, and Carole Ober. 2005. HLA-G AndImmune Tolerance In Pregnancy. The FASEBJournal Vol. 19
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Not Rejected
1. Multiple mechanismsprovide protection
2. Both the fetus and themother contribute todevelopment andmaintenence of the
pregnant uterus as animmune privilage site
3. Fetal factors drivechanges in maternalimmune respons
(Hunt, et al., 2005)
Normalpregnancy
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Hunt, et al. ,2005
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HLA
(Human
Leucocyte Antigen)
MHC(Major
Histocompatibility Complex)
System is the locus of
genes that encode forproteins on the surface
of cells that areresponsible for
regulation of the immune
system in humans Wikipedia, 2014Harliani, 2010
Function: Activatingimmune respons
(innante andadaptive immune)
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HLAE,F,G(class 1bmolecules)
HLADM,DO
HLAClass I
HLA A,B,C
(class 1a molecules)
Classical HLAclass genes
NonclassicalHLA class
genes
HLADP, DQ, DR
HLAClass
II
HLAClass
III
Selsomati
k
Activatedsubgrup immunecells
Makrofag Sel dendritik
Sel epitelkelenjar timus Harliani, 2010
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Reece,et al,
2008
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HLA G(sHLA G in amnion fluids )
HLA C
HLA E
Moffett-King, 2002
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Type of cytotoxic lymphocyte cell Large lymphocytes that have abundant
granule-containing cytoplasmWhat?
In pregnancy decidua (maternal)Where?
Trofoblast invasion in decidua 1sttrimester called uNK (Uterine NaturalKiller) cellWhen?
Moffett-King, 2002
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CSF (Colony stimulating factor), LIF (Leukaemiainhibitory factor) for trofoblast growth and differentiation
TNF- , IFN- ,IFN- , TGF- for inhibits trofoblast growth
Function:Secreatecytokine
NK cell express receptors : NKC (Nk complex of lectin-related genes on chromosome 12), LRC (leukocytereceptor immunoglobulin-lectin-related genes onchromosome 19)
HOW
Activating Inhibitory
Some of theligands for NK cellreceptors are HLA
class I
Interaction
Moffett-King, 2002
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Hunt, et al , 2005
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45 50%
20%
10%
0%
1,7%
Hunt et al , 2005 and Reece et al ,2008
1 st Trimester
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Moffett-King, 2002
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Immune respons inpregnancy that could lead to
rejection of the fetusReece et al , 200
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Immunoregulatory mechanismsin pregnancy that prevent the
rejection of the fetus In normal
pregnancy Reece et al , 200
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SUMMARY
Fetus assemiallograft
Pregnancy Fetusinvasion in decidua
Fetus(EVT)HLA
Endometrium uNK
Immunoadaptive
Fetus not rejectionNORMAL
PREGNANCY