Histology for Pathology Gastrointestinal System and Exocrine Pancreas Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP Assistant Professor Assistant Director of Mechanisms of Human Disease Loyola Stritch School of Medicine
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Histology for Pathology Gastrointestinal System and Exocrine Pancreas Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease.
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Histology for Pathology Gastrointestinal System and
Exocrine Pancreas
Theresa Kristopaitis, MDAssociate Professor
Director of Mechanisms of Human Disease
Kelli A. Hutchens, MD, FCAPAssistant Professor
Assistant Director of Mechanisms of Human Disease
Loyola Stritch School of Medicine
Objectives• On H&E stained sections, identify the four general layers of the digestive tract
organs (esophagus, stomach, small bowel, colon): Mucosa; submucosa; muscularis externa, and adventitia/serosa
• On H&E stained sections identify the following components of the mucosa: epithelium, lamina propria, muscularis mucosa
• Describe the components of the submucosal layer of the digestive organs• Explain the location of Meissner plexus vs Auerbach plexus and describe the
function of each• Name the type of epithelium comprising the mucosa of the esophagus, stomach,
small bowel, appendix, colon and anal canal.• Identify submucosal glands in the esophagus and describe their function.• Describe the composition of the esophagogastric junction• Name the four parts of the stomach.• Identify gastric pits and explain their function.• On high power H&E stained sections distinguish parietal cells from chief cells. List
the substances secreted by each of the cells.
Objectives• Identify the following key components of the small intestine:• Duodenum: villi, Brunner glands• Jejunum: villi, goblet cells • Ileum: villi, goblet cells, Peyer patches• Define Crypts (or Glands) of Lieberkuhn.• Contrast vili vs plicae circulares• On H&E stained sections distinguish colon from small intestine.• Define taenia coli.• In H&E stained sections of pancreas distinguish the endocrine
components of the pancreas from the exocrine components.• In H&E stained sections of pancreas identify pancreatic acinar cells
vs ducts.
Oral Cavity
• Inner surface of the lips, cheeks, soft palate, surface of tongue, and floor of the mouth– Nonkeratinized stratified squamous epithelium– Lamina propria– Submucosa
• Gingiva and hard palate– Keratinized stratified squamous epithelium– Lamina propria
• Tongue: specialized mucosa with papillae
Digestive Tract• Comprised of hallow organs
– Esophagus– Stomach– Small intestine– Large intestine
– Fundus and body: largest portion. Fundic glands contain parietal cells and chief cells with some stem cells, mucous cells and enteroendocrine cells
– Pyloric region: lower end that connects to duodenum; ends at pyloric sphincter. Glands primarily mucus-secreting cells and two special endocrine cells: gastrin-secreting (G cells) and somatostatin-secreting cells (D-cells)