Hemophilia B Haemophilia B ; is a recessive X- linked genetic disorder involving a lack of functional clotting Factor IX. 20% of haemophilia cases. Risk factors for hemophilia B include: 1. Family history of bleeding 2. Being male(One in 20,000–30,000 males are affected )
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Hemophilia B
Haemophilia B ; is a recessive X-linked genetic disorder involving a lack of functional clotting Factor IX.
20% of haemophilia cases.
Risk factors for hemophilia B include:1. Family history of bleeding2. Being male(One in 20,000–30,000
males are affected )
Hemophilia B-Factor IX
Factor IX ; is one of the serine proteasesof the coagulation system,a vitamin K-dependent glycoprotein
The factor IX gene is located on the X chromosome (Xq27.1-q27.2) on the “q” arm of the chromosome.
Mutations: deletions, insertions,inversion or point mutationsHemophilia B
• The Magiority have point mutations, most resulting in missense mutations