Hematopoietic Stem Cell Transplantation and Cellular Therapies

Enric Carreras Carlo Dufour Mohamad Mohty Nicolaus Kröger Editors
The EBMT Handbook
The EBMT Handbook
The EBMT Handbook
This book is an open access publication. ISBN 978-3-030-02277-8 ISBN 978-3-030-02278-5 (eBook) https://doi.org/10.1007/978-3-030-02278-5
Library of Congress Control Number: 2018960384
© EBMT and the Author(s) 2019
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Editors Enric Carreras Spanish Bone Marrow Donor Registry Josep Carreras Foundation and Leukemia Research Institute Catalunya, Barcelona Spain
Mohamad Mohty Department of Hematology Pierre and Marie Curie University Paris France
Carlo Dufour Hematology Unit IRCCS Giannina Gaslini Geneva Switzerland
Nicolaus Kröger Department of Stem Cell Transplantation University Medical Center Hamburg-Eppend Hamburg Germany
Hematopoietic stem cell transplantation has become a well-established life- saving treatment procedure for many patients with hematological malignan- cies, inborn errors, or bone marrow failure syndromes. Starting more than 60 years as an “ultima ratio” option, hematopoietic stem cell transplantation is now integrated as an essential part in many treatment concepts and protocols. The rapid development in the field with changing in transplant practices and the increasing numbers of long-term survivors require a continuous education for physician, nurses, and healthcare providers who are involved in stem cell transplantation and cellular therapies.
This new formatted EBMT Handbook, which is part of a broader EBMT educational strategy, addresses the most recent developments and innova- tions in stem cell transplantation and cellular therapy presented by more than 170 authors, known as experts and well-recognized authorities in the field. In more than 90 chapters, all types of stem cell and bone marrow trans- plantation including haplo-identical stem cell and cord blood transplanta- tion, indication for transplantation, and management of complications as well as the new rapidly evolving field of cellular therapies are covered. Other important issues such as quality management and JACIE accreditation, stem cell collection, conditioning, donor selection, HLA typing, graft manipula- tion, ethical issues, psychological support, and quality of life are also prop- erly addressed.
The aim of this new EBMT Handbook, which follows the long tradi- tion of the ESH-EBMT Handbook on Haematopoietic Stem Cell Transplantation, is not to provide an in-depth knowledge like a textbook but rather to describe the state of practice to enhance the reader’s knowl- edge and practice skills. Major key points are summarized at the end of each chapter.
The EBMT Board wants to express their great gratitude to the strong effort of the Working Party chairs and all authors in planning and writing the chapters and the tremendous work of the project leader Enric Carreras and the secretarial work of Marta Herrero Hoces from the Barcelona EBMT offices but also to Nathalie L’Horset-Poulain from Springer for her continuous support.
Preface
vi
A heartfelt thanks goes to the Fondation José Carreras pour la lutte contre la leucémie, Geneve for the unconditioned educational grant, which permits the open-access publication as well as the printed version of this EBMT Handbook.
On behalf of the EBMT board, we hope this EBMT Handbook will be of help in your daily practice.
Barcelona, Spain Enric Carreras Geneva, Switzerland Carlo Dufour Paris, France Mohamad Mohty Hamburg, Germany Nicolaus Kröger
Preface
vii
Acknowledgment
This open-access and print edition have been possible thanks to the generous contribution of the Foundation José Carreras pour la lutte contre la leucémie, Genève.
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1 HSCT: Historical Perspective 3 Rainer Storb
2 The EBMT: History, Present, and Future 11 Alois Gratwohl, Mohamad Mohty, and Jane Apperley
3 The Role of Unrelated Donor Registries in HSCT 19 Irina Evseeva, Lydia Foeken, and Alejandro Madrigal
4 The HSCT Unit 27 Walid Rasheed, Dietger W. Niederwieser, and Mahmoud Aljurf
5 JACIE Accreditation of HSCT Programs 35 Riccardo Saccardi, Eoin McGrath, and John A. Snowden
6 Statistical Methods in HSCT and Cellular Therapies 41 Simona Iacobelli and Liesbeth C. de Wreede
Part II Biological Aspects
7 Biological Properties of HSC: Scientific Basis for HSCT 49 Alessandro Aiuti, Serena Scala, and Christian Chabannon
8 Biological Properties of Cells Other Than HSCs 57 Attilio Bondanza, Ulrike Koehl, Andrea Hoffmann, and Antoine Toubert
9 Histocompatibility 61 Eric Spierings and Katharina Fleischhauer
10 Clinical and Biological Concepts for Mastering Immune Reconstitution After HSCT: Toward Practical Guidelines and Greater Harmonization 69 Jürgen Kuball and Jaap Jan Boelens
Contents
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Part III Methodology and Clinical Aspects
11 Evaluation and Counseling of Candidates 77 Enric Carreras and Alessandro Rambaldi
12 Donor Selection for Adults and Pediatrics 87 Francis Ayuk and Adriana Balduzzi
13 Conditioning 99 Arnon Nagler and Avichai Shimoni
14 Bone Marrow Harvesting for HSCT 109 Norbert Claude Gorin
15 Mobilization and Collection of HSC 117 Kai Hübel
16 Collection of HSC in Children 123 Volker Witt and Christina Peters
17 Processing, Cryopreserving and Controlling the Quality of HSCs 127 Patrick Wuchter
18 Procurement and Management of Cord Blood 131 Sergio Querol and Vanderson Rocha
19 Graft Manipulation 137 Michael Schumm, Peter Lang, and Rupert Handgretinger
20 Documentation of Engraftment and Chimerism After HSCT 143 Peter Bader
21 Short- and Long-Term Controls After HSCT 149 Montserrat Rovira and Maria Suárez-Lledó
Part IV General Management of the Patient
22 Vascular Access 157 Simone Cesaro and Federica Minniti
23 Transfusion Support 163 Hubert Schrezenmeier, Sixten Körper, Britta Höchsmann, and Christof Weinstock
24 Nutritional Support 171 Annic Baumgartner and Philipp Schuetz
25 GVHD Prophylaxis (Immunosuppression) 177 David Michonneau and Gérard Socié
26 Management ATG (SIRS) 183 Francesca Bonifazi
Contents
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27 Infection Control and Isolation Procedures 189 Malgorzata Mikulska
28 General Management of the Patient: Specific Aspects of Children 197 Francesca Riccardi and Elio Castagnola
29 Vaccinations 207 Rafael de la Cámara
30 Psychological Morbidity and Support 221 Alice Polomeni, Enrique Moreno, and Frank Schulz-Kindermann
31 Clinically Relevant Drug Interactions in HSCT 229 Tiene Bauters
32 Role of Nursing in HSCT 237 Aleksandra Babic and John Murray
33 Ethical Issues in HSCT 245 Khaled El-Ghariani and Jean-Hugues Dalle
34 Quality of Life Assessment After HSCT for Pediatric and Adults 251 Anna Barata and Heather Jim
Part V HSCT Complications and Management
35 Neutropenic Fever 259 Malgorzata Mikulska
36 Bacterial Infections 265 Diana Averbuch
37 Invasive Fungal Infections 273 Johan A. Maertens
38 Viral Infections 281 Per Ljungman, Jan Styczynski, and Hermann Einsele
39 Other Life-Threatening Infections 291 Rodrigo Martino
40 Bleeding and Thrombotic Complications 301 Shruti Chaturvedi, Binsah George, and Bipin N. Savani
41 Graft Failure 307 David Valcárcel and Anna Sureda
42 Early Complications of Endothelial Origin 315 Enric Carreras and Maribel Diaz-Ricart
43 Acute Graft-Versus-Host Disease 323 Ernst Holler, Hildegard Greinix, and Robert Zeiser
Contents
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44 Chronic Graft-Versus-Host Disease 331 Daniel Wolff and Anita Lawitschka
45 Post transplant Lymphoproliferative Syndromes 347 Jan Styczynski and Sebastian Giebel
46 Iron Overload 353 Emanuele Angelucci
47 Secondary Neoplasia (Other than PTLPS) 357 André Tichelli
Part VI Specific Organ Complications
48 Ocular and Oral Complications 367 Shahrukh K. Hashmi
49 Hepatic Complications 373 Tapani Ruutu and Enric Carreras
50 Gastrointestinal Complications 381 Grzegorz W. Basak
51 Haemorrhagic Cystitis and Renal Dysfunction 387 Simone Cesaro
52 Noninfectious Pulmonary Complications 393 Enric Carreras and Kenneth R. Cooke
53 Neurological Complications 403 Rémy Duléry
54 Skin, Hair and Musculoskeletal Complications 409 Francis Ayuk and Bipin N. Savani
55 Cardiovascular Diseases and Metabolic Syndrome 415 Diana M. Greenfield and John A. Snowden
56 Endocrine Disorders, Fertility and Sexual Health 421 Nina Salooja, Zeev Shoham, and Jean-Hugues Dalle
Part VII Prevention and Management of Relapse
57 Monitoring Minimal Residual Disease in ALL and AML 431 Peter Bader, Hermann Kreyenberg, and Gert Ossenkoppele
58 Prevention and Treatment of Relapse by Drugs 437 Nicolaus Kröger
59 Delayed Transfer of Immune Cells or the Art of Donor Lymphocyte Infusion 443 J. H. Frederik Falkenburg, Christoph Schmid, Hans Joachim Kolb, Franco Locatelli, and Jürgen Kuball
Contents
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60 Cellular Therapy with Engineered T Cells, Efficacy and Side Effects 449 Attilio Bondanza, Chiara Bonini, Boris Fehse, and Michael Hudecek
61 Mechanisms of Immune Resistance 457 Luca Vago and Francesco Dazzi
62 Regulatory Aspects of ATMP Versus Minimally Manipulated Immune Cells 461 Eoin McGrath and Christian Chabannon
Part VIII Specific Modalities of HSCT and Management
63 At-Home HSCT 467 Francesc Fernandez-Avilés and Gonzalo Gutiérrez-García
64 Umbilical Cord Blood Transplantation in Children and Adults 473 Jaime Sanz, Paul Veys, and Vanderson Rocha
65 Haploidentical HSCT 479 Fabio Ciceri, Andrea Bacigalupo, Arjan Lankester, and Alice Bertaina
66 Photopheresis in Adults and Pediatrics 487 Hildegard Greinix
67 Overweight and Obese Patients 493 Claudia Langebrake
68 HSCT in Elderly Patients 499 Rafael F. Duarte and Isabel Sánchez-Ortega
Part IX Indications and Results
69 Acute Myeloid Leukemia in Adults 507 Jurjen Versluis, Jan J. Cornelissen, Charles Craddock, Miguel Á. Sanz, Jonathan Canaani, and Arnon Nagler
70 Acute Myeloid Leukemia in Children 523 Brenda E. S. Gibson, Martin G. Sauer, and Persis Amrolia
71 Acute Lymphoblastic Leukemia in Adults 531 Matthias Stelljes and David I. Marks
72 Acute Lymphoblastic Leukemia in Children and Adolescents 539 Christina Peters, Franco Locatelli, and Peter Bader
73 Myelodysplastic Syndromes 547 Marie Robin and Theo de Witte
Contents
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75 Myelodysplastic/Myeloproliferative Neoplasms 561 Francesco Onida and Yves Chalandon
76 Myeloproliferative Neoplasms 569 Nicolaus Kröger and Yves Chalandon
77 Severe Aplastic Anemia and PNH 579 Régis Peffault de Latour, Antonio Risitano, and Carlo Dufour
78 Fanconi’s Anemia and Other Hereditary Bone Marrow Failure Syndromes 587 Cristina Díaz de Heredia, Marc Bierings, Jean- Hugues Dalle, Francesca Fioredda, and Brigitte Strahm
79 Hemoglobinopathies (Sickle Cell Disease and Thalassemia) 595 Barbara Cappelli, Eliane Gluckman, Khaled Ghanem, and Miguel R. Abboud
80 Multiple Myeloma 603 Joan Bladé, Benedetto Bruno, and Mohamad Mohty
81 Systemic Light Chain Amyloidosis 609 Monique Minnema and Stefan Schönland
82 POEMS Syndrome and Disease Produced by Other Monoclonal Immunoglobulins 615 Gordon Cook and Montserrat Rovira
83 Follicular Lymphoma 621 Stephen Robinson
84 Chronic Lymphocytic Leukemia 627 Johannes Schetelig and Peter Dreger
85 Diffuse Large B-Cell Lymphoma 633 Norbert Schmitz, Matthias Stelljes, and Ali Bazarbachi
86 Mantle Cell Lymphoma 643 Sascha Dietrich
87 Other T- and B-Aggressive Lymphomas and Lymphomas Associated with HIV 647 Kai Hübel and Silvia Montoto
88 Classical Hodgkin’s Lymphoma 653 Anna Sureda and Carmen Martínez
89 Primary Immunodeficiencies 663 Michael Albert, Arjan Lankester, and Andrew Gennery
Contents
xv
90 Inborn Errors of Metabolism and Osteopetrosis 671 Robert Wynn and Ansgar Schulz
91 Autoimmune Disease 677 Tobias Alexander, Basil Sharrack, Montserrat Rovira, Dominique Farge, and John A. Snowden
92 Solid Tumours 685 Ruth Ladenstein, Evgenia Glogova, and Francesco Lanza
Appendix: EBMT Registry 699
Miguel  R  Abboud Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
Alessandro  Aiuti San Raffaele Telethon Institute for Gene Therapy (SR-TIGET)/Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, Italy
Michael Albert Pediatrics Department, Dr. von Hauner Children’s Hospital, LMU Munich, Munich, Germany
Tobias Alexander Department of Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany
Mahmoud  Aljurf King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Persis Amrolia Department of Bone Marrow Transplant, Great Ormond St Children’s Hospital, London, UK
Emanuele  Angelucci Department of Oncology and Hematology, IRCCS Ospedale Policlinico San Martino, Genova, Italy
Jane Apperley Centre for Haematology, Hammersmith Hospital, Imperial College London, London, UK
Diana Averbuch Pediatric Infectious Diseases, Hadassah Medical Center, Hebrew University, Jerusalem, Israel
Francis Ayuk Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Aleksandra Babic IOSI-Istituto Oncologico della Svizzera Italiana, OSG, Bellinzona, Switzerland
Andrea  Bacigalupo Istituto di Ematologia, Fondazione Polclinico Universitario A. Gemelli, Universita’ Cattolica del Sacro Cuore, Roma, Italy
Peter  Bader Division for Stem Cell Transplantation and Immunology, University Hospital for Children and Adolescents, Goethe University Frankfurt am Main, Frankfurt, Germany
xviii
Adriana  Balduzzi Outpatient Hematology and Transplant Department, Clinica Pediatrica, Università degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
Anna Barata Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Barcelona, Spain
Grzegorz  W  Basak Department of Hematology, Oncology and Internal Medicine, Independent Public Central Clinical Hospital, Medical University of Warsaw, Warsaw, Poland
Annic  Baumgartner Internal Medicine and Endcrinology/Diabetology/ Clinical Nutrition and Metabolism, Medical University Clinic of Kantonsspital Aarau, University of Basel, Aarau, Switzerland
Tiene  Bauters Pharmacy, Pediatric Hemato-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
Ali  Bazarbachi Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
Alice  Bertaina Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA
Marc  Bierings Pediatric Hematology and HSCT Division, Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
Joan Bladé Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clinic of Barcelona, IDIBAPS, Barcelona, Spain
Jaap Jan Boelens Laboratory of Translational Immunology, UMC, Utrecht, The Netherlands
Princess Maxima Center for Pediatric Oncology, Blood and Marrow Transplantation Program, Utrecht, The Netherlands
Attilio  Bondanza Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, University Vita-Salute San Raffaele and Ospedale San Raffaele Scientific Institute, Milan, Italy
Francesca  Bonifazi Institute of Hematology “Seràgnoli”, University Hospital S. Orsola-Malpighi, Bologna University, Bologna, Italy
Chiara  Bonini Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, University Vita-Salute San Raffaele and Ospedale San Raffaele Scientific Institute, Milan, Italy
Benedetto Bruno Department of Oncology, AOU Città della Salute e della Scienza, University of Torino, Torino, Italy
Department of Molecular Biotechnology and Health Sciences, AOU Città della Salute e della Scienza, University of Torino, Torino, Italy
Contributors
xix
Jonathan Canaani Hematology and BMT Division, Chaim Sheba Medical Center, Tel-Hashomer, Israel
Barbara  Cappelli Eurocord-Monacord, Centre Scientifique de Monaco, Monaco, Monaco
Enric  Carreras Spanish Bone Marrow Donor Registry, Josep Carreras Foundation and Leukemia Research Institute, Barcelona, Catalunya, Spain
Hospital Clinic Barcelona, Barcelona University, Barcelona, Spain
Elio Castagnola Infectious Diseases Unit, Department of Pediatrics, Istituto Giannina Gaslini, Genoa, Italy
Simone  Cesaro Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
Christian Chabannon Institut Paoli-Calmettes, Centre de Lutte Contre le Cancer, Marseille, France
Université d’Aix-Marseille, Marseille, France
Centre d’Investigations Cliniques en Biothérapie, Marseille, France
Yves Chalandon Department of Oncology, Hematology Division, Hôpitaux Universitaires de Genève, University of Geneva, Geneva, Switzerland
Shruti  Chaturvedi Division of Hematology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
Fabio Ciceri IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy
Gordon Cook Haematology and Myeloma Studies, Leeds Cancer Centre, St James’s University Hospital, Leeds, UK
Kenneth R Cooke Pediatric Blood and Marrow Transplantation Program, Oncology Department, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Jan  J  Cornelissen Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands
Charles  Craddock Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK
Jean-Hugues  Dalle Department of Pediatric Hematology-Immunology, Hospital Robert-Debré, Assistance Publique-Hôpitaux de Paris, Paris Diderot University, Paris, France
Francesco Dazzi School of Cancer and Pharmacological Sciences, King’s College London, London, UK
Rafael de la Cámara Department of Hematology, Hospital de la Princesa, Madrid, Spain
Cristina  Díaz de Heredia Department of Pediatric Hematology and Oncology and HSCT Hospital Universitari Vall d’Hebron, Barcelona, Spain
Contributors
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Sascha  Dietrich Department of Hematology, University Hospital of Heidelberg, Heidelberg, Germany
Peter Dreger Abteilung Innere Medizin V, Universitätsklinikum Heidelberg, Heidelberg, Germany
Rafael  F  Duarte Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
Carlo  Dufour Hematology Unit, G.  Gaslini Research Children Hospital, Genoa, Italy
Rémy  Duléry Hematology Department, Hôpital Saint Antoine, AP-HP, Paris, France
Hermann Einsele Department of Internal Medicine II, Julius Maximilian University of Würzburg, Würzburg, Germany
Khaled  El-Ghariani Department of Hematology, Sheffield Teaching Hospitals Trust and NHSBT, The University of Sheffield, Sheffield, UK
Irina Evseeva Anthony Nolan, London, UK
J H Frederik Falkenburg Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
Dominique  Farge Unité Clinique de Médecine Interne, Maladies Auto- immunes et Pathologie Vasculaire, UF 04, Hôpital Saint-Louis, EA 3518, AP-HP Assistance Publique des Hôpitaux de Paris, Paris Denis Diderot University, Paris, France
Centre de Référence des Maladies auto-immunes systémiques Rares d’Ile- de- France (site constitutif), Filière FAI2R, Paris, France
Boris Fehse Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
Francesc Fernandez-Avilés Department of Hematology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Catalunya, Spain
Francesca  Fioredda Hematology Unit, Istituto Giannina Gaslini, Genoa, Italy
Katharina  Fleischhauer Institute for Experimental Cellular Therapy, University Hospital, Essen, Germany
Lydia  Foeken Word Marrow Donor Association (WMDA), Leiden, The Netherlands
Andrew Gennery Paediatric Immunology, Great North Children’s Hospital, Newcastle University, Newcastle upon Tyne, UK
Contributors
xxi
Khaled Ghanem BASMA Pediatric Oncology Unit, Al Bairouni Hospital, Damascus, Syria
Brenda  E  S  Gibson Haematology Department, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Sebastian Giebel Department of Bone Marrow Transplantation and Onco- Hematology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
Evgenia Glogova Studies and Statistics for Integrated Research and Projects, St. Anna Kinderkrebsforschung e.V., Vienna, Austria
Eliane  Gluckman Department of Hematology, Hospital Saint Louis, University Paris-Diderot, Paris, France
Norbert  Claude  Gorin Department of Hematology and Cell Therapy, EBMT Paris Office, Hôpital Saint Antoine APHP, Paris, France
Paris Sorbonne University, Paris, France
Alois Gratwohl Hematology, Medical Faculty, University of Basel, Basel, Switzerland
Diana  M  Greenfield Specialised Cancer Services, Sheffield Teaching Hospitals NHS Foundation Trust, University of Sheffield, Sheffield, UK
Hildegard  Greinix Division of Hematology, Department of Internal Medicine, University Hospital Graz, Graz, Austria
Gonzalo Gutiérrez-García Department of Hematology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Catalunya, Spain
Rupert Handgretinger Department of Hematology/Oncology and General Pediatrics, Children’s University Hospital, University of Tuebingen, Tuebingen, Germany
Shahrukh  K  Hashmi Department of Adult Hematology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Mayo Clinic, Rochester, MN, USA
Shelley Hewerdine Data Management Lead, EBMT, London, UK
Britta  Höchsmann Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service Baden- Württemberg- Hessen and University Hospital Ulm, Ulm, Germany
Institute of Transfusion Medicine, University of Ulm, Ulm, Germany
Andrea  Hoffmann Department of Orthopaedic Surgery, Laboratory of Biomechanics and Biomaterials, Hannover Medical School, Hannover, Germany
Contributors
xxii
Ernst  Holler Clinical and Experimental HSCT, Department of Internal Medicine 3 (Haematology/Oncology), University of Regensburg, Regensburg, Germany
Kai  Hübel University of Cologne, Department of Internal Medicine, Cologne, Germany
Michael  Hudecek Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany
Simona Iacobelli Department of Biology, University of Rome Tor Vergata, Rome, Italy
EBMT, Leiden, The Netherlands
Heather Jim Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA
Ulrike  Koehl Institute of Clinical Immunology, University of Leipzig, Leipzig, Germany
Institute of Cellular Therapeutics, Hannover Medical School, Hannover, Germany
Fraunhofer Institute of Cellular Therapeutics and Immunology, Leipzig, Germany
Hans  Joachim  Kolb Department of Hematology-Oncology…