HEALTHY SCAFFOLDING
HEALTHY
SCAFFOLDING
LIFESTYLE
EXERCISE/DIET/STRESS
MANAGEMENT
PATHOGEN LOAD
MICROBIOME
NEUROTRANSMITTERS
TELOMERES
GENES
ANTI AGING
STRATEGIES
LIFESTYLE
THE KIDNEY
QI
YIN
YANG
JING
“In order to grasp clinical advances
towards longevity, we must understand
metabolic health, insulin resistance and,
Type 2 Diabetes Mellitus.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814170/
Sugar
&
The Other Sugar
CYCLIN
• Atorvastatin Calcium (generic Lipitor)
• Levothyroxine (generic Synthroid)
• Lisinopril (generic Prinivil)
• Omeprazole (generic Prilosec)
• Metformin (generic Glucophage)
• Amlodipine (generic Norvasc)
• Simvastatin (generic Zocor)
29 million Type 2 DM
80 million undiagnosed Type 2 DM
Type 2 DM costs US
$
300B annually
1 of every 3 Medicare $ spent on
Type 2 DM
Four Diabetic Patients
• #1: 26 yo male. Jogs 6 miles a day, eats 1000 calories a day and
meditates. His glucose and early onset heart disease resist treatment.
• #2: 61 yo female. Osteoporosis, Cardiovascular Dx. and her Hgb A1c
is 12.5. She is taking 11 medications and it is difficult to discern which
of her many health complaints are her disease or her medications?
• #3: 42 yo male. Must exercise, eat a stringent diet - NO cheating -
and still has uncontrollable blood sugar.
• #4. 49 yo female. Exercises 6 days a week. Eats ‘clean, lean,
vegetable based diet’ and her blood sugar is consistently unstable but
her deep depression outweighs her concern about her blood sugar.
These 4 patients have in common ONLY blood
sugar and insulin dysregulation. Yet, all 4 of
these patients have the SAME diagnosis:
DIABETES
???????
CREATIVITY
“When people talk listen
completely.”
Ernest Hemingway
How Diabetes Drives
Atherosclerosishttps://www.sciencedaily.com/releases/2008/03/080313124430.htm
Artery of a Diabetic
THE ROLE
OF
SUGAR
GENES FOR DIABETES
Friendly Committee Genes
vs.Tyrant Genes
LOCK & KEY
DIABETES
DIABETES 2
• https://www.hindawi.com/journals/ecam/2014/492193/
•29.1 million + 80.1m undiagnosed
•1.4m new cases dx annually
•1 in 10 adults 20 years or older has
diabetes
“Whenever I eat sugar I
get a sore throat.”
Patient
WHY?
SUGAR
• Highly acidic.
• As humans we can’t turn sugar into vitamin C.
• Glucose and ascorbic acid compete with each other.
• Diet high in sugar will result in heat, dampness and
ultimately infection and lower vitamin C.
GLYCATION
• GLYCATION triggered by rapidly digesting carbs & sugar
• Blood Sugar Spikes Quickly = Formation of AGEs
• SUGAR + FAT or PROTEIN = Formation of AGEs
GLUCOPHAGE
METFORMIN
$5.00
METFORMIN
Dimethylbiguanide
Most widely prescribed, least expensive,
drug prescribed for diabetes 2.()
METFORMIN
• Galega officinalis (goat’s rue; French lilac)
• Nicholas Culpepper, 17th century herbalist, wrote about it’s effect
on symptoms now associated with Type 2 Diabetes.
• Shown in 1800’s to be rich in GUANIDINE
• 1930’s demonstrated guanidine effective in reducing blood sugar
• Guanidine too strong with harsh side effects for consistent use.
• 1957 - Dr. Jean Stern, French pharmacologist, diabetologist,
discovers Glucophage (Metformin).
GALEGA OFFICINALIS
METFORMIN
Geroprotective Agent?•Reduces all cause mortality &
diseases of aging independent of its
effect on diabetes control:
•a systemic review
•& meta-analysis.
• https://www.ncbi.nlm.nih.gov/pubmed/28802803
http://www.nature.com/nm/journal/v19/n10/fig_tab/nm.3373_F1.html
METFORMIN
THE SHADOW
• Metformin Lowers B12 - <B12 = > neuropathy
• 40% of Diabetics who have had diabetes for 10 or more
years - suffer with Neuropathy
• Neuropathy associated with B1 and B12 deficiency
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199287/
METFORMIN
•30-40% reduction in cancer incidence among
diabetics who use metformin in comparison with other
drugs.
•Patients using metformin showed more robust
lymphocytes
• http://www.pnas.org/content/112/6/1809.full
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666657/
Metformin
Not Only About The Earth
Is it Impacting Wood/Earth Relationship?
• Shown in 8 studies to lower elevated Liver Enzymes ALT
(Alanine transaminase) & AST Aspartate transaminase
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956897/
CASE HISTORY
WILLIAM
LIFESTYLE
THE CRACKER TESTLOW (taste doesn’t change - 30 seconds)
MEDIUM - (taste changes 15-30 sec)
HIGH - taste changes (1-14 sec)Dr. Moalem
Low Vitamin D3
• Low Vitamin D3 = macrophages stress
and increased blood pressure.
• Low D3 = higher risk for insulin
resistance and metabolic syndrome
• Note: a D3 dose of 2,000 IU daily
shown to reduce symptoms in patients
at risk for diabetes
• https://www.ncbi.nlm.nih.gov/pubmed/21715514
Higher Vitamin D Levels Associated
With Lower Pancreatic Cancer Risk
•“In two U.S. cohorts, higher intakes
of vitamin D were associated with
lower risks for pancreatic cancer. Our
results point to a potential role for
vitamin D in the pathogenesis and
prevention of pancreatic cancer.”
• https://www.ncbi.nlm.nih.gov/pubmed/16985031
Consumption of Fructose & High Fructose Corn Syrup Increase Postprandial
Triglycerides, LDL, Cholesterol & Apolipoprotein-B in Young Men & Women
• Sugar >s CVD
• Triglycerides, LDL, VLDL
• https://www.ncbi.nlm.nih.gov/pubmed/21849529
MAGNESIUM Lowers Glucose
in DiabeticsMg. Levels Inversely Associated w/ CHD,
Hypertension & Type 2 Diabeteshttps://www.ncbi.nlm.nih.gov/pubmed/28927411
The Yin & Yang of Egg Freshness
AVOIDANCE OF
GLUTEN?
CARBS?
SATURATED FATS?
TRANSFATS?
IRON?
COPPER?
Huang Lian Die Du Tang
“Coptis Decoction To Relieve Toxicity”
Relieves Heat 3 Jiaos
• “Berberine regulates insulin resistance”
• Berberine lowers blood sugar
• Regulates intestinal microbiota
• New treatment target for type 2.
• https://www.ncbi.nlm.nih.gov/pubmed/28862668
• https://www.ncbi.nlm.nih.gov/pubmed/28822177
• https://www.ncbi.nlm.nih.gov/pubmed/28843149
DR. METCHNIKOFF
Microbiome
How Our Bellies
Rule Our Brains
Bone & Microbiome
https://www.ncbi.nlm.nih.gov/pubmed/28973392
GUT MICROBIOME & THE
BRAIN
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259177/
Brain Structure & Response to Emotional
Stimuli Relates to
Gut Microbial Environment
• Gut microbiota have been associated with mood and
behavior. (metal feeding water?)
• https://insights.ovid.com/crossref?an=00006842-900000000-98803
CANCER & THE MICROBIOME
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986062/
WEIGHT & MICROBIOME
http://mbio.asm.org/content/5/3/e01011-14.full
SACCHAROMYCES BOULARDII
Reduces Body Weight & Fat Mass in
Type 2 Diabetic Mice
LACTOBACILLUS GASSERI
Reduces Weight in
Overweight Adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611107/
Lactobacillus casei - digestion, immune fx & soothes the bowels.
Lactococcus lactis - associated with leaky gut restoration
Lactobacillus gasseri - digestion, blood sugar, supports normal body weight
Lactobacillus acidophilus - digestion, especially lactose digestion & immune fx.
Lactobacillus bulgaricus - creation of natural gut antibiotics. Releases acids that neutralize
bowel toxins.
Lactobacillus paracasei - fatigue; teeth; may diminish environmental sensitivities
Lactobacillus brevis - soothes oral & colon tissue
Streptococcus thermopiles - enhances healthy tissue in small intestine.
Lactobacillus plantarum - supports calcium metabolism; hormone production; immune fx;
helps in production of L. lysine.
Bifidobacterium breve - essential for colon health; post antibiotics; variety of digestive
complaints associated with low levels
Bifidobacterium longum - balances acid levels; post antibiotics
Bifidobacterium lactis - neutralizes gliadin (wheat protein that can damage the intestinal
lining & result in leaky gut
Bifidobacterium bifidum - improves digestion & immune fx.; skin benefits
Bifidobacterium infantis - supports digestion; prevents harmful organisms from sticking to
bowel; constipation
Pediococcus acidilactici - prevents undigested food from rotting in gut; keeps harmful
organisms from inflaming bowel
Bacillus laterosporus - fights toxic organisms including candida
BODY PARTS
What We Can See
Structural Changes
About 80% of US population will
experience back pain
The Effects of Deep Abdominal Strengthening Exercises On
Respiratory Function &
Lumbar Stability
PAIN = <LUMBAR INSTABILITY
ABDOMINAL MUSCLE STRENGTH = >VITAL CAPACITYhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805012/
Reduction in Pain Medication Prescriptions &
Self Reported Outcomes Associated with
Acupuncture in a Military Patient Population
• “the number of opiod prescriptions
decreased and patients reported
improved symptom control, ability to
function and sense of well-being after
receiving courses of acupuncture.”
• https://www.ncbi.nlm.nih.gov/pubmed/28874924
Is FAT around
The abdomen
A predictor of
Cancer Risk?
https://www.sciencedaily.com/releases/2017/05/170524085530.htm
Signals from the Adipose Microenvironment and
the Cancer Link - A Systemic Review
“Moreover visceral white adipose tissue plays a more central role, as it is
more bioenergetically active and more closely associated with a more
procancer secretome.”
https://www.ncbi.nlm.nih.gov/pubmed/28864539https://www.ncbi.nlm.nih.gov/pubmed/28959684https://www.ncbi.nlm.nih.gov/pubmed/28954980
FAT CANCER?
ARE YOUR PATIENTS
SITTING
TOO MUCH?
THE KIDNEY
Source of All Yin & Yang
• Lu Zhi, “Human body is only Jing, Qi & Shen. These are
the 3 treasures. In order to attain true health & happiness,
we must value the 3 treasures. 3 treasures must not be
wasted. They must be nourished & protected as one’s life.” https://www.ncbi.nlm.nih.gov/pubmed/28386511
80.2 million Americans
over the age of 6 are
inactive
EXERCISE
WHY?
• After 2 weeks of sitting only 6 hours a day LDLs>
• Fat burning enzymes decrease = weight gain.
Physical Activity, Sedentary Behavior, and Long Term
Changes In Aortic StiffnessHigher levels of physical activity associated with a significantly slower rate of
Age Related progression of Aortic Stiffness
Aug. 2017
https://www.ncbi.nlm.nih.gov/pubmed/28784651
Gravity
• Skylab - 1970’s
• Aging in space similar to being bedridden
• Note for Patients: Try to sit for 3 hours or less each day.
VASPERhttp://vasper.com
• COMPRESSION
• COOLING
• CIRCULATION
• Androgens >
• Inflammatory markers <
• Blood sugar <
EXERCISE PREVAILS
GRAND SLAM OF HEALTH
SITTING
DEEP VEIN
THROMBOSIS• Long periods of sitting - desk, car, long flight, couch =
• Increase risk of DVT (blood clot that forms mainly in a
deep vein in the leg, which may lead to a pulmonary
embolism - often fatal)
• If one sits for more than 6 hours a day there is a 48%
increased risk of mortality from blood clots that originate
in the veins.
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291423
• http://www.acc.org/latest-in-cardiology/ten-points-to-remember/2017/03/02/15/24/diagnosis-and-management-of-acute-deep-vein-thrombosis
Replacing sedentary time w
physical activity & sleeping
•“Although replacing sedentary behavior with
walking and moderate-to-vigorous physical
activity are associated with the lowest mortality
risk, replacements with equal amounts of
standing and sleeping (in low sleepers only)
are also linked to substantial mortality risk
reductions.” Dr. Stamakis• https://www.ncbi.nlm.nih.gov/pubmed/26419654
Can TV Kill?
• 40% increased risk of pulmonary
embolism for every 2 hours of TV
watched each day beyond a threshold
of 2.5 hours.
• 5 hours or more of TV = 2.5 times
greater risk than under 2.5 hrs.
• http://circ.ahajournals.org/content/134/4/355
Too Much Sitting: The Population
Health Science of Sedentary Behavior
• Have patients take a ‘movement break’ every 30 minutes.
• Standing desks
• Note: no matter how much exercise one gets, sitting
excessively for long periods of time is a risk factor for an
earlier death
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404815/
ACTIVITY
• Physical Benefits
• Mental Benefits
• Effects of Exercise on Cognitive Function & Brain
Plasticity
• https://www.ncbi.nlm.nih.gov/pubmed/28984621
Effect of Tai Chi Chuan on degeneration of lumbar vertebrae & lumbar
discs in middle aged and aged people: a cross sectional study based on
magnetic resonance images
January, 2017https://www.ncbi.nlm.nih.gov/pubmed/28984177
• The most severely affected lumbar vertebrae & discs were
L5/L4. Conclusion: Regular performance of a simplified
Tai Chi 24 form could possibly retard the degeneration
of lumbar vertebrae & lumbar discs in middle aged
and aged people..
FACIAL CHANGES
Facial Reading
• Lillian Bridges
• https://www.amazon.com/Lillian-Bridges/e/B001ITYPG2
Skin Changes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583889/
LOSS OF YIN
WHAT Happens Outside Happens Inside
Aging-related changes in the diversity of women’s
skin micro biomes associated with oral bacteria
September 2017
• Propionibacterium - gram positive, anaerobic bacteria.
Member of the genus Propionibacterium widely used in the
production of B12, as well as in probiotics. Decreases with
aging.
• Health of the bacteria in our mouths is associated with our
skin.
• https://www.ncbi.nlm.nih.gov/pubmed/28874721
KAMILLOSANAfter 2 weeks mild superiority to
.5% CORTISONE CREAM
https://www.ncbi.nlm.nih.gov/pubmed/10799352
Heart & Kidney
Triple Heater
Pericardium
Large Intestine & Stomach
Lung & Spleen
Check Lunula
Color of Lunula
• Ivory - normal. strong & healthy
• Dark Pink - onset of heat; diabetes; hyperthyroidism
• Gray - low energy; anemia; fatigue
• Purple - stagnation; poor blood circulation of heart &
brain; lower oxygen; dizziness; headache
• Black - severe illness
NAILS
Liver Blood Flourishing
•Brittle & split easily - fatty acid, protein,
Vitamin A, Iron or Calcium deficiency.
• White flecks or lines Zinc or Vitamin B6
deficiency.
•Broaden and curve downwards at the tip may
be a symptom of lung damage.
•Excessively dry nails often B12 deficiency
NAILS(continued)
Split easily consider hydrochloric acid deficiency in the
stomach (weak earth)
•Grow slowly or dry may be indicative of a Vitamin A
or Iron deficiency
•Discoloration of the nails may be due to prolonged
illnesses or stress, smoking or allergies
•Pale color may occur due to Iron or protein deficiencies as seen in anemia, kidney or liver disorders
EAR WAX
Body Odor
Alcohol Tolerance
• Wet yellow
• Dry white
DOES EXTERIOR
STRUCTURE
RELATE TO THE
INTERNAL?
Elevated Triglycerides
Correlated with Fracture
•2000 premenopausal women with high triglycerides have
increased risk of fractures.
•An > of 50mg/dl in blood triglycerides found in annual exam was
associated with a 31% increased risk of fractures within the next
2-5 years.
•CALL TO ACTION:
• Women must lower elevated triglycerides.
•WOOD/EARTH relationship
• https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-1366
SITTING MORE THAN
10 HOURS EACH DAY
• Heart disease >s 64%
• Lifespan <s 7 years
96
BLOOD
=
communication
97
Messages
Blood delivers
messages
throughout
the body
Improper Nutrition
Compromised Digestion
Neuroendocrine Imbalances
Infections
Heavy metal & chemical
toxicity
Energetic Imbalances
Trauma & Structural problems
Genetics
CLUES
Environmental Insult
Associated With
•Dementia
•Alzheimer’s
•Parkinson’s
Which Blood Test is
THE GREATEST
BLOOD WORK BARGAIN?
C REACTIVE PROTEIN
(CRP)
CRP is produced in the liver. It is
considered an ‘acute’ phase biomarker
and increases with inflammation.
Measuring HEAT
C REACTIVE PROTEIN >
Prevalence of Metabolic Syndrome,
Hypertension & Diabetes 2
https://www.ncbi.nlm.nih.gov/pubmed/28914081
C REACTIVE PROTEIN
High CRP correlated with depressive symptoms in patients
with schizophrenia.
https://www.ncbi.nlm.nih.gov/pubmed/28917193
<Magnesium = > CRP
http://www.jle.com/download/mrh-278789-magnesium_and_its_relationship_to_c_reactive_protein_among_hemodialysis_patients--Wb-xd38AAQEAAB@GVqQAAAAF-a.pdf
<Selenium = >CRP
https://link.springer.com/article/10.1007/s12011-007-8018-2
<Zinc = >CRP
>Endothelial Cell Senescence
Zinc + Sage Oil
< Inflammation <CRP <Sugar
https://www.ncbi.nlm.nih.gov/pubmed/28858729
< Zinc
> CRP
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429802/
https://www.ncbi.nlm.nih.gov/pubmed/26846364
> Iron
< Zinc
Alzheimer’s >s
Dementia >s
https://www.ncbi.nlm.nih.gov/pubmed/28554217
Andrea
Case History
STEALTH
PATHOGENS
“Defects in the regulatory circuits of the host
that control bacterial homeostasis, through
environmental changes (infection, diet or
lifestyle), may disturb the symbiotic
relationship and promote disease”
HIJACKED
1 in 6 cancers worldwide
associated with infection
Chronic Illness
Infection
HIV vs. EBV
• Chronic Viral Infections
• HIV
• Virus that destroys the cell
• EBV
• Virus that makes itself at home
Cytomegalovirus (CMV)
AGE ACCELERATOR
•60-90% of us harbor this infection
•Known to shorten life span
•Adversely affect cognitive thinking
•Damage endothelial lining of our arteries
•Speed Immune Senescense
Aging =
decreased ability
to fight infection
IMMUNE SENESCENCE
Aging of Immune System
http://www.anti-agingfirewalls.com/2014/09/08/prospectus-for-reversing-age-related-immune-senescence/
Serious infections, Cancers &
Inflammatory Disease Leading
Causes of Premature Death
Immunosenescence of Aging
•“Aging is a complex process that negatively impacts the
development of the immune system and its ability to function.
The mechanisms that underlie these age-related defects are
broad and range from defects in the haematopoietic bone
marrow to defects in peripheral lymphocyte migration,
maturation and function. The thymus is a central lymphoid
organ responsible for production of naïve T cells, which play a
vital role in mediating both cellular and humoral immunity.”
• https://www.ncbi.nlm.nih.gov/pubmed/14996423
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931833/
Aging & Autoimmune
Disorders
• With aging immune competence fades
• Thymic T cell & B cell greatly reduced
• https://www.ncbi.nlm.nih.gov/pubmed/22466672
AGING = < IMMUNE FX
•More Vulnerable To Infection, Chronic Dx & Malignancy
•Bu Zhong impact - IMPROVES IMMUNOLOGICAL
RESPONSE
•120 days of 7.5gm daily
•Natural Killer Cell Activity against K562 target cells
significantly enhanced
•Significant increase in serum IFN-gamma level (interferon)
• https://www.ncbi.nlm.nih.gov/pubmed/14996423
TCM
PATHOGENIC SLAYER
• Shang Han Lun - Six Divisions (3rd century)
• Wen Bing - Four Levels (18th century)
Yin Qiao Jie Du Pian vs.
Gan Mao Ling
ANTI VIRAL
Gan Mao Ling
HEAT CLEARING
• Gang Mei Gen (Radix Ilex Asprella)
• San Cha Ku (Radix Evodia Lepta)
• Ban Lan Gen (Radix Isatis)
• Jin Yin Hua (Flos Lonicera)
ANDROGRAPHIS FORMULA
CHUAN XIN LIN
• ACHYRANTHES - Huai Niu Xi
• ANDROGRAPHIS - Chuan Xin Lin
• COPTIS - Huang Lian
• LICORICE - Gan Cao
• PLATYCODON GRANDIFLORUS - Jie Geng
• RHIZOMA CORYDALIS - Yanhusuo
Bu Zhong Impact on
Lung Inflammation•These results suggests the possibility that BZ may enhance
inhibition of pulmonary-alveolar macrophage inflammation
response to TLR-ligands stimulus in conditions of high blood
glucose.
•Note: We know asthma is a complex disease of the lungs, which
is characterized by airway inflammation and airway
hyperresponsiveness (AHR). Alveolar macrophages (AMs), one
of the prominent immune system cells found in the airways, have
been implicated in the development and progression of asthma.
• EARTH FEEDING METAL
• http://erj.ersjournals.com/content/38/Suppl_55/p3865
Higher IL-6 Levels Associated With a
2 Fold Increased Risk of Death
Centenerians have
unusually LOW levels of
Interleukin 6
Pu-Erh Tea - Yunnan Province
Hei Cha
• Inhibits Interleukin 6
• Increases Natural Killer Cells
• Increases Naive T Cells
QUERCETIN
• Plant flavonoid shown to protect against the damaging
influence of pesticides.
• Improves liver & kidney fx
• Inhibits oxidative stress
QUERCETINRheumatoid Arthritis
500MG. Daily 8 Weeks
<Early morning stiffness
<Morning pain
Inflammatory Biomarkers Reduced
https://www.ncbi.nlm.nih.gov/pubmed/24146468
Dihydroquercetin
1)Flavonoid that allows Vitamin C greater
longevity & efficacy
2) Inhibits lipid peroxidation
3) Lowers LDL
4) Reduces oxidative stress
5) Aids in inhibition of chronic bacterial & viral
infections
Cistanche
Rou Cong Rong
• Supports increased lifespan in
animals
• Optimizes the ratio of CD4 to CD8
cells = younger immune system.
Protective Effects of Ancient Common
Kidney Tonic
Cistanche - Rou Cong Rong
Epimedium - Yin Yang Huo
Polygonatum - Yu Zhu
Significantly protects against neurological damage
Parkinson’s Researchhttps://www.ncbi.nlm.nih.gov/pubmed/28386511
THE EARTH
THE BREAST
BREAST Arterial Calcification Is A Strong
Indicator of
Coronary Arterial Calcification•76% of the 371 women scanned,
those with breast arterial calcification
score of 0 also had a coronary artery
calcification score of 0.
•As the breast arterial calcification
score increased there was a similar
increase in the coronary artery
calcification score.
AGING & THE EARTH
HEARTBURN60% of US Adults will experience
Gastroesophageal Reflux Disease
(GERD) within a 12 month period
20-30% - weekly symptoms
GERD speeds the
Aging of Blood Vesselshttp://circres.ahajournals.org/content/early/2016/04/19/CIRCRESAHA.116.308807
PPIS
• PPIs inhibit proton pumps
• Specifically the
• proton/potassium pump of the
• parietal cells of the stomach.
PPIs
HERE LIES THE RUB
Shutting down the EARTH
• PPIs are not only found in the stomach.
• They are in almost every cell in the body with the
exception of the RED BLOOD CELLS.
• With the shutting down of PPIs energy systems - ATP
cycle is compromised and the TRANSPORTATION of
nutrition and energy substances must rely on other
systems such as anaerobic secondary systems which
don't function very efficiently.
PPIs meant to be prescribed for 8-
12 weeks but are often used for
years
Proton Pump Inhibitors
Speed the Aging of Blood
Vessels
Proton Pump Inhibitors> Dementia
>Cognitive Impairment w short term PPIs
(Nexium, Prevacid, Prilosec)
http://jamanetw ork.com/journals/jamaneurology/fullarticle/2487379?version=meter%20at%200&module=meter-
Links&pgtype=Blogs&contentId=&mediaId=%%EF%BF%BDID%%&referrer=https://w w w.google.com/&priority=true&action=click&contentCollection=meter-links-click
Patients 75 & older who use PPIs
Have a 44% greater risk of dementia
Including Alzheimer’s
60% of people using
PPIs don’t require them
Proton Pump Inhibitors
Among Top 10 Prescribed Classes of Drugs
• PPIs second only in sales to Statins
• Used to treat
• Indigestion
• Acid Reflux
• Peptic Ulcers
ABOUT 20 million
Americans Suffer With
GERD
Proton Pump Inhibitors
Popular Heartburn Drugs Linked to >ed
Early Death Risk
• Prevacid; Prilosec; Nexium Etc.
• Linked to a variety of health problems:
• Kidney Damage
• Bone Fractures
• Dementia
• WHY?
• Resulting cascade from Diminishment of the Earth?
• Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Yan Yan, Ziyad Al-Aly. Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans. BMJ
Open, 2017; 7 (6): e015735 DOI: 10.1136/bmjopen-2016-015735
Alternatives to PPIs
• 1. Resolve Stomach Heat & Harmonize Wd/Earth
• TCM Calcium Carbonate - Hai Jiao Xiao https://www.redpinechineseherbs.com/blogs/chinese-herb-blog/6340188-hai-piao-xiao-good-for-stomach-acid
• 2. Calcium Carbonate, Magnesium Carbonate,
Deglycyrrhizinated Licorice Extract - neutralize stomach
acid without shutting down production of stomach fx.
• 3. Melatonin -protects epithelial tissue of GI Tract
https://www.ncbi.nlm.nih.gov/pubmed/25562159
FARE YOU
DIETARY
STRATEGIES
Dietary Oxidative Stress
Contributes to Age Related
Degenerative Dx
• CANCER
• DIABETES TYPE 2
• MACULAR DEGENERATION
• ALZHEIMER’S
• PARKINSONS
BASIC DIETARY
STRATEGIES• DELETE HEAT CREATING FOODS (INFLAMMATORY)
• Sugar
• Overcooked, burnt meats
• Elimination of processed foods, food additives
• Elimination of plastic & toxic metals: arsenic, aluminum,
etc.
CASE HISTORY
ELISABETH
“Foods are not drugs but over a
lifetime of repetitive consumption
they can alter the trajectory and
development of disease.”
Super Food
Or
Super Habits
The RESET Button
RESEARCHED FOODS• POMEGRANATE
• CILANTRO
• PARSLEY
• GARLIC
• GINGER
• CELERY
• WILD BLUEBERRIES
• RASPBERRIES
• ASPARAGUS
• SPINACH
• BROCCOLI
Higher Dietary Potassium Linked
to Lower Risk of Death, Stroke
• “High potassium intake is associated with a lower risk of
all stroke and ischemic stroke, as well as all-cause
mortality in older women, particularly those who are not
hypertensive.”
• https://www.ncbi.nlm.nih.gov/pubmed/25190445
SUPPLEMENTS and
Western BOTANICALS• CURCUMIN
• RED CLOVER
• ELDERBERRY
• NETTLE LEAF
• LICORICE ROOT
• CAT’S CLAW (alkaloid removed)
• LEMON BALM
• ZINC
• SELENIUM
• L-LYSINE
• ESTER C (BUFFERED C)
• OMEGA 3’S , DHA, EPA & ESSENTIAL FATTY ACIDS
• METHYLCOBALAMIN
• METHYLFOLATE - 5-MTHF - (5-METHYLTETRAHYDROFOLATE)
• VITAMIN B1 (Benfotiamine)
DANG SHEN
CODONOPSIS
•TONIFY MIDDLE BURNER
•Regulated Liver Enzymes & Alkaline
Phosphatase better than placebo
•Improved biomarkers associated
with senescence • https://www.ncbi.nlm.nih.gov/pubmed/28671103
DIETARY
STRATEGIES•KETOGENIC DIET
•LOW CARBOHYDRATE/MEDITERRANEAN DIET
•GLUTEN FREE DIET
•MAPS DIET
•VEGAN DIET
•VEGETERIAN DIET
•CALORIE RESTRICTION DIET
•BLOOD TYPE DIET
•ATKINS DIET
•RAW FOOD DIET
•WEIGHT WATCHER’S DIET
•SOUTH BEACH DIET
•HIGH PROTEIN DIET
CALORIE RESTRICTION
BENEFITS NON-OBESE
Giving The Center A Rest•218 subjects (30% men & 70% women) BMI 22-28
•2/3 of subjects 25% calorie restriction for 2 years
•1/3 no restriction for 2 years
•Calorie Restriction Group lost 16.7 pounds
•Improved Sleep after 1 year
•Decreased tension/stress
•Improved Mood
•Increased Energy
•Improved Sex Drive
• http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2517920
DIETARYFISH EATING VEGETARIANS
Lowest Risk of Colorectal Cancer
•77,659 Pescaterians
•Vegetarians who also ate fish - men
and women had 27% lower risk of
contracting colorectal cancer.
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420687/
Fish Eating Vegetarians Have
Lowest Risk of Colorectal Cancer
•Compared to non-vegetarians
43% reduced risk of colorectal
cancer with vegetarian diet &
fish once or more a month
• http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2174939
NUTRIENT
TIMING
FAT SOLUBLE
VITAMINS• Fat soluble supplements such as Omega 3’s, Vitamin E,
Vitamin A, Vitamin D, CoQ10, Vitamin K, Lycopene
• Absorbed differently than water soluble vitamins
• Best taken w meal providing the most dietary fat - heaviest
meal of the day
• Note: Heaviest meal usually contains more dietary
mutagens - fried, overcooked etc. - so fat soluble
vitamins ideally taken with DNA protective supplements
such as chlorophyl, blueberry, pomegranate
Offending Substances
YIN & YANG
SODIUM
• Average American consumes 10 times minimum
requirement for SODIUM AND 2x as much sodium than
potassium
• Consuming 5x more potassium than sodium is
recommended for individuals with hypertension
PROCESSED MEATS
Group 1 Carcinogen
•Eating only 50 grams
(2oz) daily of processed
meats increases risk of
colorectal cancer by 18%
Artificial Sweeteners•Because artificial sweeteners are SWEET,
they encourage sugar craving. Repeated
exposure creates flavor preference. The more
of one flavor we eat - the more we desire it.
•In order for us to reverse obesity epidemic -
do we have to retrain the universal
tastebuds?
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892765/
ALCOHOL
• “Although excessive drinking has negative health
consequences, these results suggest that regular,
moderate drinking may play a role in cognitively healthy
longevity.”
• https://www.ncbi.nlm.nih.gov/pubmed/28671111 (June 28, 2017)
CARDIOVASCULAR
DISEASE
(CVD)
Contributors to CVD• Hypertension
• Hyperlipidemia
• Hypergylcemia (Dysglycemia)
• Stress
• Hypersympathetic Nervous System
• Elevated Cortisol (PM)
• Lifestyle
• Diet
• Exercise
HYPERTENSION
Marker for Vascular Dysfunction• Often first biomarker to be detected
• Normal 120/80 mmHg but risk for CVD has been noted
beginning at 110/70 mmHg.
• Each > of 20/10 doubles cardiovascular risk
• **Before age 50 diastolic (pressure in your arteries
between beats) BP is best predictor of risk
• **After age 50 systolic (maximum pressure your heart
exerts while beating) BP is best predictor of risk
TCM Increased BP
PHASE 1
• Excess Syndromes - Hyperfunctioning
• Liver Yang Excess >
• Qi Stagnation
• Blood Stasis
• Accumulation of Phlegm & Dampness
TCM Increased BP
PHASE 2
• Deficiency
• Qi Deficiency W/ Blood Stagnation
• Yin Deficiency sets in
• Phlegm accumulates & causing
obstruction
TCM Increased BP
PHASE 3
• Deficiencies & Stagnations more pronounced
• Liver & Kidney Qi & Yin Deficiencies
TCM Strategies To
Lower BP
• Resolve Dampness & Phlegm
• Activate Blood & Resolve Stagnation
• Rid Wind & Harmonize Liver
• Nourish Yin
24 Hr. BP Monitoring
• Early Detection
• Most Important Issue
CASE HISTORY
RICHARD
Resistant Hypertension
Hx: 3 cardiologists over 7 years
Rx: Diuretic
&
3 Hypertensive Medications
BP Medications
TIMING
• Most meds should be given at night (Exception Diuretics)
• Taking meds at night - 25-50% < in CV risk due to
stroke & MI.
• WHY? (Reinforcing Yin Function?)
• Down regulates ̂ BP morning reactions
Jiang Ya Pian
MELATONIN LOWERS
BLOOD PRESSURE In Male Patients
9 MG. controlled release melatonin daily 6 weeks
7.3 - 13.3mmHg lowers systolic
http://hyper.ahajournals.org/content/43/2/192
DAN SHENhttps://www.ncbi.nlm.nih.gov/pubmed/19943333
http://www.worldscientific.com/doi/abs/10.1142/s0192415x86000053
MAGNESIUM
• 4th most abundant mineral in body
• 300 enzymes need magnesium to fx properly
• Regulates Blood Sugar
• Protects Blood Vessels
• Regulates Heart Function
• Brain’s Neurological Activity
Magnesium
Over Age 70
• 80% of men & 70% of women FAIL to get the minimum
requirement of 350 mg. for men & 265mg. for women
Drugs Interfering With
Magnesium Absorption
•Proton Pump Inhibitors
Higher Risk of Death
With Magnesium Deficiency
• Low Mg. accelerates aging at the cellular level
• Harder for good cells to replicate and provide in healing
Magnesium
• The risk of death is significantly higher in people 65 and
older who have lower Mg. blood levels.
• 55% of hospitalized patients who had <levels of Mg. died
• VS.
• 35% of hospitalized patients who had normal levels of Mg.
died
MAGNESIUM
• 50 mg. > of daily MG. intake decreased calcification of the
heart’s main arteries by 22% AND
• 12% reduction in calcification of the aorta
• Highest MG. intake = 58% less likely to have calcification
of the coronary arteries AND
• 34% less likely to have any calcification of the abdominal
aorta
MAGNESIUM
• BLOOD SUGAR
• BONES
• DENTAL
• MIGRAINES
• https://www.ncbi.nlm.nih.gov/pubmed/26082204
Magnesium Helps to
Reduce Wiry Pulse
LIPIDS
Is measurement of
Total Cholesterol Obsolete?
CHOLESTEROL - ESSENTIAL FOR LIFE
NO CHOLESTEROL = NO LIFE
•We eat it
•We make it
•We store it
•We excrete it
ENDOGENOUS
SYNTHESIZED CHOLESTEROL
• Dominant source of cholesterol is in our body
• Most of the cholesterol in our body was made by our body
• Dietary cholesterol has relatively little impact on the
cholesterol levels in our body
Cholesterol Transport In Plasma
• Cholesterol travels from
• the liver (wood) and
• small intestine (fire)
• towards the periphery
• and back to the liver and
• small intestine.
CONVENTIONAL BIOMARKERS
Cholesterol Normals
Analyte Optimal Desirable Threshold for Intervention
Total ≤ 150 ≤ 200 ≥ 200
HDL (female) ≥ 50 ≤ 50
HDL (male) ≥ 40 ≤ 40
TG ≤ 100 ≤ 100 ≥ 100
TG/HDL ≤ 3 ≤ 4 ≥ 4
LDL ≤ 100 ≤ 130 ≥ 160
Units are mg/dl
Wood Earth
Relationship
?
STATIN
EZETIMIBE
Lowers blood cholesterol interfacing and
preventing absorption in the
Small Intestine
Hyperlipidemia
Blood Stasis
Xuefuzhuyu Decoction
•LDL Reduction
• https://www.ncbi.nlm.nih.gov/pubmed/28707604
WHY IS THE EARTH SO
IMPORTANT TO COMBAT AGING?
•TRANSFORMATION &
TRANSPORTATION OF
NUTRITION
•THE RESOLUTION OF JUNK
Transformation
&
Transportation
•EXTRACELLULAR JUNK
•INTRACELLULAR JUNK
PASTY LOOKING
RATS
•Pasty loose stools, decrease in endurance, lackluster, loose
stool, loose & disorderly behavior, <ed weight of liver & spleen.
•The restorative effect of BZYQT in rats w spleen deficiency
confirmed. Four identified biomarkers correlated w sp. qi xu.
These biomarkers are all identified as playing a role in energy,
protein assimilation & glycolytic metabolisms.
•Treatment with BZYQT restored compromised biomarkers.
• https://www.ncbi.nlm.nih.gov/pubmed/24333365
EXTRACELLULAR JUNK
EJ
• Accumulations of sticky, malformed proteins that no longer
serve their function, but instead impair cell or tissue
function by their presence.
• Most EJ is known as AMYLOID
• Beta Amyloid - most well known EJ - identified with the
brain plaques of Alzheimer’s & all of us aging - slowing
our mental function
WARFARIN
BLOOD THINNER
Inhibits the Vitamin K dependent synthesis of clotting
factors
TURNING TO STONE
Warfarin
Increased Peripheral Calcification
With RX: WARFARIN
• Warfarin blocks Vitamin K.
• After 30 days: Warfarin 50% increased prevalence of
arterial calcification
• Warfarin use associated with increased breast calcification
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859382/
OTHER AMYLOIDS
• CARDIOVASCULAR DISEASE
• Senile Cardiac Amyloidosis (closely associated w heart
failure)
• TYPE 2 DIABETES
• Islet Amyloids (EJ accumulating on the pancreas)
Lifestyle Markers Predict Cognitive Function
9/17
“Modifiable biomarkers that impact cognitive performance favorably include greater aerobic
fitness & strength, lower blood sugar levels, lower body fat, avoidance of tobacco and alcohol
intake.”
https://www.ncbi.nlm.nih.gov/pubmed/28910193
HIGH FAT DIET
Heat
INTRACELLULAR JUNK
IJ
Heat & Stagnation
• BIOCHEMICAL MISHAPS during normal metabolism
• Our cell constituents are all ultimately damaged and compromised
• We have exceptional mechanisms for clearing debris & reusing
what is useable.
• LYSOSOMES
• Cellular debris eaters
• With age the functionality of the lysosome is not always
perfect - leading to an accumulation of debris and/or the cell
implodes from excess debris burden.
LYSOSOMES
STAGNATION MONITORING
•The debris that has not been destroyed and disposed
of or recycled accumulates in the wrong places
(STAGNATION).
•Stagnation is the lesser problem. More importantly:
•Cells that are meant to last a lifetime (eyes, heart,
lungs, brain)
•Compromised - garbage disposal - junk accumulates
- impairs inherent cell function - and ultimately tissue
function -and then organ function = AGING
STRATEGY FOR IMPROVING
GARBAGE IN & GARBAGE
OUT
•Strengthening Water
•Strengthening Earth
•Smoothing Wood/Earth
Case History
Melissa
Non Alcoholic Fatty Liver Disease (NAFLD)
• Most common cause of abnormal liver function among US
adults
• 32% of general population in India
• Ultrasound - radiation free; cost effective
Chronically Elevated
Cortisol = Inflammation =
Aging
Strategies
For Balancing Cortisol
Botanical
Magnolia Xin Yi Hua
Phellodendron Huang Baihttps://www.ncbi.nlm.nih.gov/pubmed/23924268
ALZHEIMER’S & NUTRIENTSVitamins A, C, E, D3, B1, B6, B9, B12,
Magnesium, Choline, Inositol, Anthocyanins,
Isoflavones
VITAMIIN D3
Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis.
Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated
with an increased risk of age-related chronic diseases, including Alzheimer’s disease,
Parkinson’s disease, cognitive impairment, and cancer.
http://w w w.cell.com/cell-reports/fulltext/S2211-1247(16)31362-6
D3Engages Longevity Genes To > Lifespan
Prevents Accumulation of Toxic Proteins
Associated with Chronic DX (e.g.Alzheimer’s)
VITAMIN B12• Peripheral Nerves
• Spinal Cord
• Impaired Mental Function: memory; slower thinking; confusion
• Inhibition of methionine synthase, key enzyme responsible for the
conversion of homocysteine to methionine. High Homocysteine correlated with damaged blood vessel lining (endothelial tissue) and
more susceptible to clotting.
• Compromised methylation (one molecule passes a methyl group, which is a carbon atom linked to three hydrogens, to another molecule, it’s a
basic biochemical process)- takes place a billion times a second in our bodies.
• https://www.researchgate.net/profile/C_L_Chao/publication/51360581_Effect_of_short-term_vitamin_folic_acid_vitamins_B6_and_B12_administration_on_endothelial_dysfunction_induced_by_post-
Methionine_load_hyperhomocysteinemia/links/54d9b6b00cf2970e4e7c886c/Effect-of-short-term-vitamin-folic-acid-vitamins-B6-and-B12-administration-on-endothelial-dysfunction-
induced-by-post-Methionine-load-hyperhomocysteinemia.pdf
METHYLFOLATE
Vitamins C & E Lower Risk of
Developing Cognitive Decline
23% Lower
http://journals.sagepub.com/doi/full/10.1177/1060028016673072
Vitamin C May Encourage Compromised
Blood Stem Cells To Die
• Vitamin C speaks to compromised stem cells in the bone
marrow to mature and die normally.
• https://www.sciencedaily.com/releases/2017/08/170817141722.htm
Reduced Risk of ALZHEIMER’S With Use
of
ANTIOXIDANT VITAMIN SUPPLEMENTS
•Antioxidants (Vit. E&C)
protect the brain against
oxidative damage preventing
Alzheimer’s cascade
ALZHEIMER’S
PREVENTATIVE STRATEGIES
• METAL CHELATORS
• ANTIOXIDANTS
• ANTIHYPERTENSIVES
• VITAMINS: E, B12, B6, FOLATE
• NEUROTRANSMITTER SUPPORT
• HERBS (Ginkgo biloba)
• COLD WATER FISH (reduces beta-amyloid plaques)
• DHA***
ALZHEIMER’S & SATURATED FAT DIET
• High intake of processed saturated fat - doubles the risk of
Alzheimer’s disease.
• Moderate intake of trans fat > risk by 2-3 times
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140705/
OBESITY
&
ALZHEIMER’S DISEASE
• After age 40 - obesity associated with a reduction in gray matter
(neurons) in the brain.
• High insulin levels associated with higher incidence of Alzheimer’s
Dx.
• Insulin deficiency or Insulin resistance can increase aggregation of
the amyloid beta or tau proteins associated with Alzheimer’s Dx.
• Dr. Suzanne Craft - use of moderate doses of insulin to improve
cognition in early onset Alzheimer’s Dx.
• https://www.ncbi.nlm.nih.gov/pubmed/28372335
SEX
•Frequent Sexual Activity
Improves Mental Cognition
in Older Adults
• http://neurosciencenews.com/aging-brain-sex-6960/
Higher DHEA Levels Associated with
Lower Risk of Diabetes 210 yr. study - top 1/3 serum DHEA =
27% lower risk of diabetes
Testosterone
Improves Insulin Sensitivity
in Diabetic Men
• PARTICIPANTS WITH LOW TESTOSTERONE RECEIVED A
WEEKLY TESTOSTERONE INJECTION OR PLACEBO FOR 24
WEEKS.
• Body weight, body fat, inflammatory markers, insulin sensitivity
assessed before & after.
• Loss of 6 pounds & > in muscle mass.
• Decreased C Reactive Protein (CRP)
• DRAMATIC increase in insulin sensitivity
• 32% increase in the uptake of glucose by tissues in response to
insulin
Hormonal
Replacement Therapy
• Optimize gut & liver/GB physiology prior and during HRT
• Improve adrenal & insulin physiology prior & during HRT
• Benefits & Risks of HRT
• Delivery systems for HRT: topical; ingestible; pellets