Healthy Aging: Role of Soy Protein Suresh Itapu, Ph.D. Consulting Scientist – DuPont Nutrition & Health Copyright © 2012 Solae, LLC. All rights reserved. Solae™ and the Solae logo are trademarks of Solae, LLC.
Healthy Aging: Role of Soy Protein Suresh Itapu, Ph.D.
Consulting Scientist – DuPont Nutrition & Health Copyright © 2012 Solae, LLC. All rights reserved.
Solae™ and the Solae logo are trademarks of Solae, LLC.
© Datamonitor and Solae, 2010
Developing a lifestyle of good behaviors
… nutrition, exercise, preventative healthcare, etc.
that will enable consumers age 40+ to
enjoy full health and vitality
while extending life expectancy and quality of life
What Is the Healthy Living Segment?
New opportunities are developing as a consequence of our aging society.
Awareness of the aging process begins to impact consumer mindset
around 40, and adapts based on health state going forward.
Healthy Aging: A Hot Topic In Today’s Media
April 25, 2011 February 10, 2010
Healthy Living
A Large and Rapidly Growing Market Segment: Nearly 769 Million Consumers Over the Age of 65 by 2020
North America 61,558,900, +36.2%
Latin America 57,165,000, +42.8%
Mid East & Africa 61,543,600, +42.0%
Western Europe 93,655,800, +18.6%
Eastern Europe 52,950,300, +14.6%
Asia Pacific 437,558,800 , +52.1%
Australasia 4,991,100, +39.4%
2020 Projected Population >65 Years of Age
% Change 2010-20
Source: Euromonitor, 2012
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Who Represents the “Aging” Segments?
40-50’s
Milind Soman
Born 1965
50-60’s
Shashi Tharoor
Born 1956
60-70’s
Sunil Gavaskar
Born 1949
70-80’s
Amitabh Bachchan
Born 1942
Madhuri Dixit
Born 1967 Hema Malini
Born 1948
100+
Fauja Singh
Born 1911
Healthy Living
How is the Aging Opportunity Impacting
the Food Industry?
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Healthy Living
Market Analysts See Opportunities For Food
Marketers Across The Aging Spectrum
“FORTY IS THE
NEW TWENTY” “SENIORS DRAW
ATTENTION”
• Consumers’ desire to hold
onto youth, maintain an
active, vibrant lifestyle, &
defy the aging process is
creating demand for
products that speak to their
mental, not physical, age.
• Growing number of seniors
is creating demand for
targeted nutritional products,
products with adapted taste,
texture, packaging.
2 of the Top 10 Trends Shaping the Future
of the Food and Beverage Industry
Source: Innova Market Insights, 2012
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Healthy Living
How Food Marketers Are Positioning Today to
Capitalize on The Aging Opportunity
“FORTY IS THE
NEW TWENTY” “SENIORS DRAW
ATTENTION”
Example positioning for health maintenance –
bone, eye; energy, anti-aging, mental sharpness
Example positioning for more serious & multiple health
issues, joint health, calorie/nutrient density, easy-open
packaging
Source: Innova Market Insights, 2012
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Healthy Living
Consumer Perception of Protein Needs as They Age
Q: We would like to know more about your attitudes toward
proteins. How much do you agree with each of the following
statements . . .
47%
87%
73%
57%
40%
55%
66%
69%
42%
75%
• India, China, Brazil,
South Korea –
indicate higher levels
of agreement >70%
(top-2 box).
• North America and
Western European
countries indicate
lower agreement,
overall.
• Across all markets,
consumer education
on this issue will be
key to product
success.
Source: Solae’s Global Healthy
Aging Consumer Survey, 2011
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Healthy Living
The Market Opportunity
• Population trends indicate that the aging market is growing in
numbers and influence and will be a key force in shaping
future opportunities in the health and wellness market.
• Targeting & positioning will be challenge, as the market
represents very diverse needs, niches and interests.
• The market for protein enhanced foods and beverages
targeting aging populations is one analysts predict is well
positioned for future growth.
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Healthy Living HEALTHY LIVING
• Soy Protein Opportunities for
the Aging Population Copyright © 2012 Solae, LLC. All rights reserved.
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Healthy Living
World Health Organization Report (2002) Active Aging: A Policy Framework. WHO/NMH/NPH/02.8
Realities of Aging
Functional capacity increases in childhood, peaks in early adulthood and then declines
Rate of decline is determined by lifestyle (diet, physical activity, smoking), external and environmental factors
The acceleration in decline can be influenced, even reversed, at any age
In the realities of aging, one must consider that older people are not
a homogeneous group, individual diversity tends to increase with
age and one’s health choices are important at all stages of life.
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Healthy Living
Theories of Aging
Native Protein &
DNA
Damaged Protein &
DNA
↑ROS
Antioxidant
X Oxidative
Stress
Oxidative Status of Older Cells 3 molecular mechanisms
An increase in oxidative stress
A decreased resistance to DNA
damage and/or ability to repair
damaged DNA
A decreased resistance to
prevent protein damage
↑ X
Ryan-Borchers et al. (2006) compared
consumption of (2 X353 ml/day) soy milk
or cow’s milk in post-menopausal women
over 16 weeks
↓ 8-deoxy-
guanosine
Soymilk
Ames et al. (2010) J Nucleic Acids 2010: 1-10 Ryan-Borchers et al. (2006) AJCN 83(5): 1118-25
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Metabolic syndrome is rapidly
becoming a major global health
problem.
Soy protein could play a role in effective lifestyle intervention.
Metabolic Syndrome
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Healthy Living
Metabolic Syndrome – A Vicious Cycle Adapted from Gong Z et al. (2012) Int J Endocrinol. 2012:1-13 discovermagazine.com/2007/feb/visceral-fat
Aging Chronic
Inflammation
Visceral
Fat
There’s a link between aging, accumulation of visceral fat,
inflammation and development of metabolic syndrome.
Metabolic Syndrome
Obesity
Hypertension
Cardiovascular Disease
Insulin Resistance
Type II Diabetes
Visceral fat increases with age
Increased visceral fat induces inflammation
Chronic inflammation accelerates aging process
Visceral or “intra-abdominal” fat, is thought to be the primary fat depot
related to obesity co-morbidities
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Healthy Living
Metabolic Syndrome & Soy Protein (SP)
Consumption
Obese, postmenopausal, women
Casein (n=16) vs soy (n=17)
20g protein/day in shakes
No weight loss or gain was noted (no change in BMI)
SP induced a significant reduction in total and abdominal fat after 3 months
Sites CK et al. (2007) Fertil Steril 88: 1609-1617
Assessed by CT Scan
Soy protein decreases abdominal fat.
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Healthy Living
Metabolic Syndrome & Soy Protein (SP)
Consumption
Criteria Thresholds Soy Protein (SP) Impact vs Control Diets
Abdominal Obesity Men > 40 in (102 cm); Women > 35 in (88 cm)
SP can be useful in weight management programs1
Plasma Triglycerides (TG)
≥ 150 mg/dL (1.7 mM) SP consumption is associated with lower TGs2
HDL-Cholesterol (HDL-C)
Men < 40 mg/dL (1.03 mM); Women < 50 mg/dL (1.29 mM)
SP consumption maintains HDL-C levels2
Blood Pressure (BP) ≥ 130 / ≥ 85 mm Hg SP consumption is associated with lower BP3
Fasting Blood Glucose (FBG)
≥ 110 mg/dL SP consumption is associated with lower incidence of diabetes in
some populations4,5,6
1Cope MB et al. (2008) Obes Rev 9:219-235; 2Harland JI et al. in Soy: Nutrition, Consumption & Health, Nova Publishers, in press; 3Dong JY et al. (2011) Br J Nutr 106: 317-326; 4Villegas R et al. (2008) Am J Clin Nutr 87: 162-167; 5Nanri A et al. (2010) J Nutr 140: 580-586; 6Mueller NT et al. (2012) Eur J Nutr, doi 10.1007/s00394-011-0276-2
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Heart Health
Heart Disease is the number one cause of death
globally.
In 2004, 7.2 million and 5.7 million people died
due to coronary heart disease and stroke,
respectively.
By 2030, it is projected that 23.6 million people
will die due to heart disease and stroke.
http://www.who.int/mediacentre/factsheets/fs317/en/index.html (2009)
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Healthy Living
A Number of Meta-Analyses Confirm Cholesterol
Lowering Property of Soy Protein Anderson JW (1995) NEJM 333:276; Zhan S & Ho SC (2005) AJCN 81:397; Balk E et al. (2005) AHRQ Pub No 05-E024-2;
Reynolds K (2006) Am J Card 98:633; Harland JL & Haffner TA (2008) Atherosclerosis 200: 13; Anderson JW et al. (2011) J
Am Coll Nutr 30: 79-91; Harland JI et al. (2012) in Soy: Nutrition, Consumption & Health, Nova Publishers
13/29 (45%) 16/20 (80%) 33/50 (66%) 24/27 (89%) 18/30 (60%) 26/43 (61%) 16/27 (59%)
Studies using
Solae® soy
protein
Soy protein consumption is associated with lower cholesterol.
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Healthy Living
Soy Protein Consumption and Blood Pressure
Consumption of soy
protein is associated
with a reduction in
Systolic and Diastolic
Blood Pressure (SBP &
DBP) when it replaces
carbohydrate or a non-
dairy protein in the diet
Studies show that soy
lowers BP similarly to
dairy protein so that
there is a more modest
or no net effect of soy
protein when compared
to dairy protein Data summarized from studies using soy protein isolate
Adapted from: Dong J-Y et al. (2011) Br J Nutr 106: 317-326
Soy protein consumption is associated with lower blood pressure.
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Healthy Living
Soy Protein Consumption Reduces Progression of
Carotid Atherosclerosis in Postmenopausal
Women
Parallel design (3 years)
Postmenopausal women
25 g/protein: 2 x 12.5 g
protein as bar or
beverage:
Total milk protein
(Placebo) (N=163)
Soy protein (ISP)
(N=162)
Carotid intima-media
thickness (CIMT) every 6
months
Hodis HN et al. (2011) Stroke 42: 3168-3175
These data are the first
to show a direct effect of
soy protein consumption
on a physical measure of
blood vessel health and
provide support for the
heart health benefit of soy
protein. Copyright © 2012 Solae, LLC. All rights reserved.
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Healthy Living
Soy Protein Diet Increases Skilled Forelimb
Reaching Function After Stroke in Rats
*
* * *
*p<0.04
Cheatwood JL et al. (2011) Behav Brain Res 216: 681-684
Improvement in stroke outcome, if translated to humans, could have a
significant impact on the quality of life post-stroke.
Male Long Evans hooded
rats
2 diet groups (21% PROT;
12% FAT):
Caseinate
Soy protein
While on diet rats trained to
reach for sugar pellet until
consistent success
achieved
Surgical stroke induced by
occluding middle cerebral
artery
Forelimb reaching
measured daily for 8 weeks
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Muscle Loss and Sarcopenia
Nutritional intervention and exercise can
help alleviate muscle loss.
Soy protein can supply adequate amino
acids needed to maintain muscle.
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Healthy Living
Muscle Loss and Sarcopenia
A complex, multi-factorial process facilitated by a more sedentary lifestyle and less than optimal diet
Involuntary muscle loss
After age 30, there is a 3-8% reduction in lean muscle mass per decade
Affects about 30% of individuals over 60 years of age and more than 50% of those over 80 years
Dietary derived amino acids are the primary source of muscle protein synthesis
Amount of dietary protein needed appears to be greater in the aging populations
Paddon-Jones D et al. (2009), Curr Opin Clin Nutr Metab Care, 12(1) 86-90 . Narici MV et al. (2010) Br Med Bull. 95:139-59
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Healthy Living
Body weight decreases in 60% of the population after age 60-65.
Much of the weight loss is loss of muscle mass.
Changes in Body Weight over Lifespan
Adapted from Wittert GA: Obesity in older adults. In Geriatric Nutrition. CRC Press; 2007: 46-58 Adapted from Morley JE et al: Sarcopenia and cachexia. In Geriatric Nutrition. CRC Press; 2007: 59-68
Birth Adolescence Adulthood ‘Aging’
Ch
an
ges in
Weig
ht
Age-related
weight gain
Growth
spurt
Age-related
weight loss
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Healthy Living
Sarcopenia – Muscle Loss, Fat Accretion
Muscle
(light
gray)
Fat
(dark
gray)
Roubenoff R et al. (2003) J of Gerontology, 58(11) 1012-1017, 2003
MRI images of a 25-yr old vs a 75-yr old (both healthy)
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Healthy Living
Mechanism for Development of Sarcopenia
Healthy Skeletal Muscle
Anabolism (muscle
synthesis)
Catabolism (muscle
breakdown)
Physical Activity Insulin Resistance
Skeletal Muscle Atrophy
Inflammation Oxidative Stress (ROS)
Aging Process
Increased protein intake, along with exercise, is essential to
maintain or increase muscle mass in the sarcopenic elderly.
Adapted from Roubenoff R et al. (2000) J. Gerontol A Biol Med Sci. (12):M716-24. Jackman RW et al. (2004) Am J Physiol Cell Physiol 287:C834-C843
Protein Intake
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Healthy Living
Effect of Protein Source on Exercise-Induced
Changes in Muscle Strength in Older Men
Baseline
12-week
New
ton
•se
c-1
New
ton
met
er•
sec-1
Men (age 51-69)
Replaced 50% of protein intake with soy (n=11) protein meat analog or beef (n=10) protein
Included resistance training over the 12-week study duration
Diet Diet
Assessment of Upper and Lower Body Muscle Strength
0
500
1000
1500
2000
2500
VEG BEEF 0
500
1000
1500
2000
2500
VEG BEEF
Knee Extension Arm Pull
Both diet groups showed increased muscle strength and cross-sectional area
Serum LDL, TC and HDL increased with beef-containing diet but not with soy
D ( POST – Baseline ) P value
CHOL ( mmol /L) VEG – 0.06 + 0. 7 0.160 BEEF – 0.30 + 0. 3
HDL - C ( mmol /L) VEG – 0 .10 + 0. 1 0.0 04 BEEF – 0 .08 + 0 . 1
LDL - C ( mmol /L) VEG – 0 .08 + 0. 6 0. 102 BEEF – 0 .3 0 + 0. 4
( POST – Baseline ) P value
CHOL ( mmol /L) VEG – 0.06 + 0. 7 0.160 BEEF – 0.30 + 0. 3
HDL - C ( mmol /L) VEG – 0 .10 + 0. 1 0.0 04 BEEF – 0 .08 + 0 . 1
LDL - C ( mmol /L) VEG – 0 .08 + 0. 6 0. 102 BEEF – 0 .3 0 + 0. 4
Adapted from Haub M, et al. (2005) Metab Clin Exp. 54:769-74
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Clinical Nutrition Soy is a high quality protein.
Clinical data for soy protein in enteral
(tube feeding) nutrition is limited.
Soy/dairy blends are used in many
enteral products.
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Healthy Living
Protein Energy Malnutrition (PEM) in the
Elderly Population
Nu
rsin
g H
om
e
Ho
spit
al
Co
mm
un
ity
Reh
abili
tati
on
50.5%
38.7%
13.8%
5.8%
Sample of elderly people from 12 countries by nourishment status. The prevalence of malnutrition was 22.8% overall with variability noted
between the settings above.
Kaiser MJ et al. (2010). J Am Geriatr Soc 2010, 58:1734-1738
Confirms that there is a persistent and significant incidence of
PEM in the elderly population. Copyright © 2012 Solae, LLC. All rights reserved.
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Healthy Living
Mean Intake of Energy and Macronutrients, by
Age, Sex, and Race/Ethnicity: Protein
0
20
40
60
80
100
120
140
20-29 30-39 40-49 50-59 60-69 70-79 80+
Age, y
Gra
ms
of
Pro
tein
In
tak
e/D
ay
White Men
White Women
Black Men
Black Wome
Wakimoto P et al. (2001) J Gerontol A biol Sci Med Sci,56 Spec No 2; p 65-68
This may be an indication that protein adequacy is compromised
for a majority of older adults.
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Healthy Living
Aging and Age-Associated Diseases and
Conditions
Protein Energy Malnutrition (also Vit D, Vit B12, Ca++)
Chronic Inflammation Immune Dysfunction (Immunosenescence)
Pro-inflammatory cytokines
• Cardiovascular Disease • Renal Disease • Osteoporosis • Arthritis • Metabolic syndrome/Type 2 Diabetes • Alzheimer’s disease/cognitive decline
• Frailty (sarcopenia, sarcodynia) • Body composition changes ( adipose, muscle)
• Susceptibility to infections • Response to vaccines • Cellular aging • Susceptibility to cancer • Chronic pain
Schiffrin EJ et al. (2010) MutRes 690: 50-56; Morley JE (2002) Curr Opin Gastroenterol 18: 240-245; Marik PE et al. (2010) JPEN 34: 378-386
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Healthy Living
Reduced Gastrointestinal (GI) Symptoms in
Soy-Based vs Casein-Based Enteral Nutrition Espin NV G-T et al. (2010) Nutr Hosp 25: 606-612
Parallel design; tube
feeding (enteral)
Mean age = 79 yrs
14-28 days on enteral
nutrition
Casein-based tube
feed (N=24)
Soy-based tube
feed (N=26)
Formulations differed
only in protein source
Soy protein based enteral formula equally effective at restoring
nutritional status as casein-based formula.
*p<0.05
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Healthy Living
Soy is a High Quality Protein - PDCAAS (Protein
Digestibility-Corrected Amino Acid Score)
Soy protein is a high
quality protein
Solae’s SUPRO ISP
(Isolated Soy Protein) has
a PDCAAS score of 1.00
SUPRO ISP is
comparable to high
quality animal proteins
(casein, egg white, beef)
ISP is the only widely
available high quality
plant-based protein
ISP is low in fat and
saturated fat and is both
lactose- and cholesterol-
free
PDCAAS is the globally recognized method for
determining protein quality based on amino
acid profile and digestibility
Hughes GJ et al. (2011) J Agric Food Chem. 59(23):12707-12
(ISP)
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How to Translate the Opportunity and Science Into Foods and Beverages Consumers will Love
Applications for Soy Protein Targeting Aging Consumers
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Healthy Living
Soy Protein Product Forms
• Example Applications:
– Powders:
• Beverages
• Liquid/Semi-Liquid Systems
• Nutrition Bars
• Bakery
• Extruded Systems
• Meat/Poultry
– Textured Flake
• Meat/Poultry
• Breakfast Cereal
– Extruded Crisp
• Nutrition Bars
• Breakfast Cereal
• Snack Mixes
• Toppings
Powders
Textured
Flake
Extruded Crisp
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Healthy Living
Solae’s Broad Application Expertise
Solae maintains a library of concepts
targeting adults, demonstrating the
versatility and application depth of our
soy proteins.
Beverages:
Ready-to-Drink, Dry-Blended,
Spray-Dried, Acidic (i.e.,
Smoothies) & Neutral (Milk-
Type)
Nutrition Bars:
Baked, Extruded, Slab (Sheet & Cut) Snacks & More:
Extruded Snacks,
Snack Mixes &
Toppings, Crackers,
Cookies, Puddings,
Soups & More
Protein Supplements: Powders,
Chews & Novel Formats
Breakfast Cereal:
Hot/Cold, Extruded,
Flake, Granola Type
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Healthy Living
Where Are the Strongest Opportunities for
Protein?
Market Predictions:
• New Formats for Protein Fortification Will Emerge:
Food and Beverage Forms Familiar to Target
• Protein Supplements Will Also Play a Key Role; New
Delivery Formats Will Emerge (i.e., Chews,
Gummies, Shots)
• Foods, Beverages, Supplements to Address Specific
Health Concerns & Conditions of Aging
• Taste, Texture, Nutrient Density Execution in
Formulation Will Play A Key Role In Market Success
• Products Targeting Specific Day-Parts, Particularly
Breakfast and Snacks
• Active lifestyle support – products addressing energy,
endurance and performance needs
• Positioning To Benefit & Mindset, Not Age Will
Enhance The Appeal of Brands
Supple-ments
Novel Formats
Condi-tion
Specific
Meal Occasions
Taste, Texture
Execution
Nutrient Density
Benefit Position-
ing Snacks
Breakfast Active
Lifestyle
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Why Soy
Protein?
Protein Quality
Health Benefits
Economic Value
Perform-ance
Applica-tion
Versatility
Sustain-ability
To Execute on the Opportunity,
You’ll Need Proteins that Deliver . . .
• High-Quality, Plant-Based
• Unique Health Benefits
• Economic Value (Price, Supply Stability) vs. Dairy
• Excellent Flavor & Functional Performance
• Versatile Across Multiple Applications
• Sustainability – Requires less land, energy & natural resources to produce than animal-based proteins
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Healthy Living
Summary
Soy protein has many health and nutrition
benefits for the aging population
Including soy protein in the diet as a high-
quality protein source helps aging adults:
• Improve Heart Health
• Intervene in the development of Metabolic
Syndrome
• Maintain muscle mass especially with resistance
training
• Benefit enteral nutrition
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Healthy Living
Summary
• The future is bright for protein-enhanced foods and beverages targeting aging consumers:
• Spurred by market growth, emerging science, consumer awareness, ingredient technology
• Science suggests that protein needs increase with aging, and soy protein has unique benefits for aging consumers
• The diverse needs, interests and lifestyles of aging consumers will create opportunities to deliver the benefits of protein in many different food, beverage and supplement formats
• Solae can help further explore the opportunity:
• Consumer Insights, Concept Ideas, Marketing, Nutrition and Product Development Support
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Healthy Living
Thank You