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Harvard-MIT Division of Health Sciences and Technology HST.121: Gastroenterology, Fall 2005 Instructors: Dr. Raymond Chung
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Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most

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Page 1: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most

Harvard-MIT Division of Health Sciences and Technology HST.121: Gastroenterology, Fall 2005 Instructors: Dr. Raymond Chung

Page 2: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 3: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 4: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 5: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 6: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 7: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 8: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most

Image removed due to copyright reasons.

Features of chronic liver injury leading to stellate cell (lipocyte) activation and induction of fibrosis (from Friedman)

Page 9: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 10: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 11: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 12: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 13: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 14: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 15: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 16: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 17: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 18: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 19: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most

Image removed due to copyright reasons. Please see:

Carithers, R. L., Jr., et al. "Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial."

Ann Intern Med 110 (1989): 685-90.

Page 20: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 21: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 22: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most

PTX

PLA

Page 23: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 24: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 25: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 26: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 27: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most

Alcoholic cirrhosis: treatment

• no effective treatments identified

l ici– Corticosteroids – Co ch ne

Page 28: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 29: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 30: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 31: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 32: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 33: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 34: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 35: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most
Page 36: Harvard-MIT Division of Health Sciences and Technology HST ... · Alcoholic cirrhosis: clinical features silent in up to 40% o frequently manifests as portal H TN, liver failure most

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