Harnessing the Power of Data From Our Bodies –Toward Personalized Preventive Medicine Invited Talk 8 th Latin American Seminar on Science and Health Journalism Institute of the Americas on UCSD Campus La Jolla, CA November 1, 2010 Dr. Larry Smarr Director, California Institute for Telecommunications and Information Technology Harry E. Gruber Professor, Dept. of Computer Science and Engineering Jacobs School of Engineering, UCSD Follow me on Twitter: lsmarr 1
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Harnessing the Power of Data From Our Bodies –Toward Personalized Preventive Medicine
Harnessing the Power of Data From Our Bodies –Toward Personalized Preventive Medicine. Invited Talk 8 th Latin American Seminar on Science and Health Journalism Institute of the Americas on UCSD Campus La Jolla, CA November 1, 2010. Dr. Larry Smarr - PowerPoint PPT Presentation
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Harnessing the Power of Data From Our Bodies –Toward Personalized Preventive Medicine
Invited Talk
8th Latin American Seminar on Science and Health Journalism
Institute of the Americas on UCSD Campus
La Jolla, CA
November 1, 2010
Dr. Larry Smarr
Director, California Institute for Telecommunications and Information Technology
Harry E. Gruber Professor,
Dept. of Computer Science and Engineering
Jacobs School of Engineering, UCSD
Follow me on Twitter: lsmarr1
Leading Causes of Preventable Deaths in the United States in the Year 2000
Mokdad AH, Marks JS, Stroup DF, Gerberding JL (March 2004). "Actual causes of death in the United States, 2000". JAMA 291 (10): 1238–45.
Sensor data +Clinical & Personal Health Record Data + Ecological data on determinants of health + Analysis & comparison of parameters in near-real time (normative and ipsative) +Sufficient population-level data to comprehend trends, model them and predict health outcomes +Feedback in near real-time via SMS, audio, haptic or other cues for behavior or change in Rx device
= True Preventive Medicine!
Sensors embedded in the environment
Geocoded data on safety, location of recreation, food, hazards, etc
Over the Next Decade and Explosion of Health Sensing:Center for Wireless &Population Health Systems
CitiSense –New NSF Grant for Fine-Grained Environmental Sensing Using Cell Phones
CitiSenseCitiSense
contributecontribute
distributedistribute
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““display”
display” disc
over
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retrieve
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Seacoast Sci.Seacoast Sci.4oz
30 compounds4oz
30 compounds
EPA
CitiSense TeamPI: Bill Griswold
Ingolf KruegerTajana Simunic Rosing
Sanjoy DasguptaHovav Shacham
Kevin Patrick
C/A
L
S
W
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Intel MSPIntel MSP
LifeChips: the merging of two major industries, the microelectronic chip industry
with the life science industry
LifeChips medical devices
Lifechips--Merging Two Major Industries: Microelectronic Chips & Life Sciences
65 UCI Faculty
The Future of Health Care Will be Dominated by a Vast Expansion in Human Health Data
• Growth of Digital Data is Exponential– “Data Tsunami”
• Driven by Advances in Population-Wide Digital Detectors, Networking, and Storage Technologies
• Making Sense of it All is the New Imperative– Data Analysis Workflows– Data Mining– Visual Analytics– Multiple-Database Queries– Data-Driven Applications– From Individual Data to
Health Outcomes
Source: SDSC
Measuring the State of Your Body So You Can “Tune” Your Body to Have a Healthier Longer Life
Goal: Improve My Omega-3 ScoresTo Protect Against Future Heart Disease
If your Omega-3 Score
is at least 7.2 and your DHA Score is
at least 4.5, you are 32% less likely to
develop heart disease
If your EPA+DHA Score is at least 4.6,
you are 70% less likely of dying from a
heart attack.
Ref: Based on Lemaitre et al., n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am. J. Clin. Nutr. 77:319-325 (2003).
Graphics from www.anne-marie.ca/ratiokits/
= My Values Tested by yourfuturehealth.com
Goal: Lower Ratio of Arachidonic Acid to EPA to Reduce Pro-Inflammatory Potential of Your Cells
Range Source: Barry SearsMy Tests by www.yourfuturehealth.com
Chronically IllAmerican
Average “Healthy”American
Ideal RangeMy Range
“Silent Inflammation”
I take 6 Fish OilPills Per Day
hsCRP Should Be <100
Goal: Quantitatively Monitor the State of Your Inflammation and Immune System
“Come Back When You Have a Symptom”
Invisible Episodic
Colon Immune
Response
Symptom: Acute Diverticulitis
Antibiotics
hsCRP from Blood Tests
Others from Stool Tests by
yourfuturehealth.com
Lactorferrin Should Be <73
25x Normal
15x Normal
Future Challenge: Danger of Persistent hsCRP Inflammationand Destabilized Microbiome
?
Blood Tests I Do Quarterly to AnnuallyIn Addition to hsCRP, Lipids, Minerals, & Omegas
Organ-Specific Blood Proteins Will Make the Blood a Window into Health and Disease
• Perhaps 50 Major Organs or Cell Types– Each Secreting Protein Blood Molecular Fingerprint
• The Levels of Each Protein in a Particular Blood Fingerprint Will Report the Status of that Organ – Probably Need Perhaps 50 Organ-Specific Proteins Per Organ
• Will Need to Quantify 2500 Blood Proteins from a Drop of Blood– Use Microfluidic/Nanotechnology Approaches
Key Point: Changes in The Levels Of Organ-Specific Markers Can Assess Virtually All
Disease Challenges for a Particular Organ
Source: Lee Hood, ISB
You Can Download This Presentation at lsmarr.calit2.net