Human Papillomavirus Vaccine-associated Neuroimmunopathic Syndrome in Japan Shumpei Yokota Professor Emeritus, Yokohama City University Professor of Medicine, Institute of Medical Science, Tokyo Medical University Trustee of Japan Medical Research Foundation HANS Syndrome from Clinical and Pathophysiological View Points 薬害オンブズパースン会議 シンポジウム(2015.11.23.於東京) 「子宮頸がんワクチン」問題を考える」 1
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Human Papillomavirus Vaccine-associated Neuroimmunopathic Syndrome
in Japan
Shumpei Yokota Professor Emeritus, Yokohama City University
Professor of Medicine, Institute of Medical Science, Tokyo Medical University
Trustee of Japan Medical Research Foundation
HANS Syndrome from Clinical and Pathophysiological View Points
Number of Synptoms & Signs of 88 Patients with HANS
Each patient has 10~29 manifestations. Each symptoms & signs is getting worse or better independently. The main manifestations come and go during the course of the disease.
Symptoms due to Locomotor, Sensory and Autonomic Nervous System Disorders, and Cognitive Dysfunction
Symptoms & Signs of HANS Systems disordered
10
Symptomatological Analysis Responsible Locus in CNS of HANS
Cerebral cortex
Basal ganglia
Thalamus Limbic system
Brain stem
cerebellum Hypo-
thalamus Hypo-physis
Locomotor system symptoms
++ ++ + ― ++ ++ ++ ―
Somatosensory system symptoms
+ + ++ + + ― + ―
Optic/auditory/gustation system symptoms
+ ― + + + ― + +
Allergic symptoms ― ― ― ― ― ― + ―
Autonomic nerve system symptoms
+ ― + ― ++ ― ++ ―
Endocrine system symptoms
― ― ― ― ― ― ++ ++
Emotional/cognitive symptoms
++ + + ++ + + ++ +
(黒岩義之) 11
Symptomatological Analysis Responsible Locus in CNS of HANS
Cerebral cortex
Basal ganglia
Thalamus Limbic system
Brain stem
cerebellum Hypo-
thalamus Hypo-physis
Locomotor system symptoms
++ ++ + ― ++ ++ ++ ―
Somatosensory system symptoms
+ + ++ + + ― + ―
Optic/auditory/gustation system symptoms
+ ― + + + ― + +
Allergic symptoms ― ― ― ― ― ― + ―
Autonomic nerve system symptoms
+ ― + ― ++ ― ++ ―
Endocrine system symptoms
― ― ― ― ― ― ++ ++
Emotional/cognitive symptoms
++ + + ++ + + ++ +
The primary central locus of HANS will be the hypothalamus-hypophysis axis.
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We proposed a new clinical disease entity ; the HPV-associated neuroimmunopathic syndrome
( HANS )
Sum total of these symptoms and signs is a collection of them, and has a unique consistent pattern that does not readily fit into an existing diagnostic entity.
The same set of manifestations was seen in different patients.
They have been completely in normal physical condition and neuropsychiatric status before HPV vaccination. Their disorders were started just after the HPV vaccination.
The complex of of these symptoms and signs were manifested in young females, but not in males no males.
The age of patients were mostly between 14 ~ 19 years of age, and rarely below 13 and over 20. Thus, they belong to HPV vaccine-recommended age group.
⇒ HANS is a new disease entity occurred following HPV vaccination.
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CRPS or POTS is merely a psychosomatic functional disorder, and thus excercising will be the best way of treatment alternatives !
Why are the severe adverse events of HPV vaccine reported solely from Japan
but not from other foreign countries?
Question 2
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Frequency of Adverse Events in Denmark and UK
Denmark UK Japan
No. of Vaccination 1,635,768 7,632,759 8,898,150
No. of People Vaccinated
630,000 2,670,000 3,380,000
No. of Patients with AE
1,730 8,243 (reported cases: 2,600)
No. AE 11,529 19,359
AD Patients/1,000 vaccinated
2.7 3.1 Suspected No. of Patients 9,126 ~ 10,478/3,380,000
DK: DHMA, Drug Analysis Print:Data lock 2015/7/31 UK: MHRA, Case Series Drug Analysis Print:Data lock 2015/6/5 JP: PMDA AE Data Base:Data lock 2015/4/30
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AEs Reported from DM, FR, and UK DHMA / ANSM / MHRA