Haemoglobin Word Search G11 E Q N C D T D G K M Y O G L O B I N E U Z Z N E G Y X O Y B M Q T O X Y H A E M O G L O B I N I P P X Y A W I Q M E V W H V X E C U A N N B F L Z J Z L U H U A X G X J B R G J H N H A E M O G L O B I N V D G H C U R V E M Y V K L E B E O S N C A AA C V P Y C K X X F A B X K Y N M D Y I D D Y F L C C V V J N U L I R H T C I C H B Y H G R J O R P V B D E P P U G W L T A J M W A V L I J Y I K D Z D S F Y G I L J F S G W O M G S Q L H O T K K E X D K W C J A I B D Q K O J G P O Z K W M Z X D F M X Y C H F R T B L V E B W M R R O Q S L H L A A H G O Q S N A I E W N O O Y N P W B L S M F D T E D R I R K M Z M R O X W H S F B G Z F N U F Z E Q K N C C D T D P A R T I A L P R E S S U R E C G K E U Z C Z P N E Y B M Q B O H R E F F E C T T I P P N A X Y A W F I I A O L Q M E V W H V X E C U A N N B F L Z C R J Z L U E N H U I L A X G X J B G J H N V D G H M Y V K A B L B E O T I S N T C A AA C V Y C K X X F A B X K Y N M R O D Y I D A B Y F A L C C V V J N U I R H T C I C B Y H G B X R J C O L O R P I V D E P P U G W L T J M W A V L I J I O Y K D A Z D L S F C A Y G I J F S G W O M T G Q L H O T K N H K E R N X G K W O F C J A I B D Q K J G P L O Z K W N Z A A X D B O P O F M S F X Y C H F T B L A V E B U W M O Q R T E R Q O I R M S L S I H L A H G O Q S T N A I E D R W U N E M O Y N T O E N P I N W B L S M F T E N D R I R I A K A M Z O M R D A T A O X D I W H S F B Z F N E U E L C S U M T F Z G E Q I R E H N C D T T D G K E U Z Z C Y B M Q T I P E P X L Y A O U I W I Q M Y E V W H V X E C A U A N N B F L R Z J O Z L X T N U H U A X G X J B G J H N L V D G H M Y V N K L B B E I A O S N C A AA C V Y C K X X P F A B X K Y N A M D I Y I D S D Y F L C C V V J N U I R H T C I C B Y H G R R J N O R E M E A H P V D E P P U G W L T J M W A V L I J Y I K D Z D S F Y G I J F S G W O M 25 Words to find PLACENTA SATURATION AFFINITY REDBLOODCELL HYDROGENCARBONATE CARBONDIOXIDE IRON DISSOCIATION MUSCLE PLASMA PARTIALPRESSURE CURVE OXYGEN KPA HAEMOGLOBIN CARBOXYHAEMOGLOBIN HAEMOGLOBINIC QUATERNARY FETAL PROTEIN MYOGLOBIN HAEM ADULT OXYHAEMOGLOBIN BOHREFFECT Myoglobin is a haemoglobin-like, iron-containing pigment found in muscle fibres. It consists of a single alpha polypeptide chain and binds only one oxygen molecule (as opposed to haemoglobin which binds 4 oxygen molecules). The oxygen dissociation curve for myoglobin is hyperbolic (as opposed to the sigmoidal curve for haemoglobin) and is to the left of that for haemoglobin. Myoglobin takes up oxygen from the haemoglobin in the blood and stores oxygen within the muscle itself. S-shaped (sigmoidal) curve that shows the partial pressures of oxygen ( pO2) in relation to the % saturation of haemoglobin. At 50 % saturation (indicated on the curve by p50), half of the haemoglobin binding sites contain oxygen molecules. From the curve you can see that at high pO2, as in the pulmonary capillaries, haemoglobin is nearly 100 % saturated. This point is shown by the red arrow. You can also see that at low pO2, as in exercising muscles, haemoglobin saturation is much lower and oxygen is released. This point is shown by the blue arrow. The dissociation curve is sigmoidal in shape because binding of the 1st O2molecule increases the affinity of haemoglobin for oxygen, making it easier for the next oxygen molecule to bind. Changes in blood CO 2 and hydrogen ion concentration (pH) cause shifts in the oxygen dissociation curve. These shifts enhance oxygen release in tissues and enhance oxygen uptake in the lungs. This is known as the BOHR EFFECTIn exercising tissues, pCO2is high and hydrogen ion concentration, [H + ], is also high due to the formation of carbonic acid which dissociates to form bicarbonate ions and hydrogen ions (there is more information on this reaction in the carbon dioxide transport section). This increase in CO 2and decrease in pH shifts the dissociation curve to the right for a given pO 2 , releasing more oxygen to the tissues. In the lungs, pCO2is low and hydrogen ion (H + ) concentration is also low. This decrease in CO2and increase in pH shifts the dissociation curve to the left for a given pO2, enhancing oxygen uptake. Haemoglobin-Oxygen Dissociation Curve
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