• Grants/strategies Grants/strategies NIH NIH AHA AHA • Transition from postdoc to independent Transition from postdoc to independent investigator investigator Scientific direction Scientific direction Independence from former mentor Independence from former mentor Need for continued mentorship Need for continued mentorship Institutional support Institutional support Road to Independence
Road to Independence. Grants/strategies NIH AHA Transition from postdoc to independent investigator Scientific direction Independence from former mentor Need for continued mentorship Institutional support. NIH Grants for Early Career Investigators. - PowerPoint PPT Presentation
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• Grants/strategiesGrants/strategiesNIHNIHAHAAHA
• Transition from postdoc to independent investigatorTransition from postdoc to independent investigatorScientific directionScientific directionIndependence from former mentorIndependence from former mentorNeed for continued mentorshipNeed for continued mentorshipInstitutional supportInstitutional support
Road to Independence
• NIH grants for early investigatorsNIH grants for early investigatorsK series (K01, K08, K23, etc.)K series (K01, K08, K23, etc.)K99/R00 (Pathway to Independence Award)K99/R00 (Pathway to Independence Award)R21R21R01R01DP2 (NIH Director’s New Innovator Award)DP2 (NIH Director’s New Innovator Award)
• NHLBI “discount”NHLBI “discount”New investigator (NI) – no prior R01 or similar grantNew investigator (NI) – no prior R01 or similar grantEarly stage investigator (ESI)Early stage investigator (ESI) – NI within 10 years of degree or residency – NI within 10 years of degree or residency - payline 5 percentile points higher - payline 5 percentile points higher
• NIH website for early career investigatorsNIH website for early career investigatorshttp://grants.nih.gov/grants/new_investigators/index.htmhttp://grants.nih.gov/grants/new_investigators/index.htm
NIH Grants for Early Career Investigators
• 12 page NIH application12 page NIH applicationchallenge for young investigatorschallenge for young investigators
• Only one resubmission allowedOnly one resubmission allowed
• Importance of clarity and readabilityImportance of clarity and readability
• Institutional supportInstitutional supportacademic position of PIacademic position of PIlab space, protected time, core facilities, etc.lab space, protected time, core facilities, etc.
• Independence/separation from former mentorIndependence/separation from former mentor
• Mentoring planMentoring plan
• Common flaws (overambitious, dependency of aims, Common flaws (overambitious, dependency of aims, significance)significance)
• Get application done early and reviewed internallyGet application done early and reviewed internally
• Talk to your NIH program officerTalk to your NIH program officer
• Plan to resubmit or try again!Plan to resubmit or try again!
Grant application strategies
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Age
at
Firs
t R0
1 A
war
d
Fiscal Year
Age at First R01 Equivalent Award from NIHFY 1980 to 2009
MD-PhD
MD Only
PhD Only
Age data for FY 2009 are preliminary
Development of the ESI Development of the ESI PolicyPolicy
• Concern about the number of New Investigators Concern about the number of New Investigators • Related concern about increasing age at first Related concern about increasing age at first
awardaward• Search for age-independent policySearch for age-independent policy• Develop ESI policyDevelop ESI policy
– Modeled on NIH Director’s New Innovator AwardModeled on NIH Director’s New Innovator Award– Ten years from most recent doctoral degree or Ten years from most recent doctoral degree or
medical residencymedical residency
• Enrich the applicant pool with enough ESIs to Enrich the applicant pool with enough ESIs to reduce the average age at first awardreduce the average age at first award
• Designed to encourage individuals and Designed to encourage individuals and institutions to accelerate the period of training institutions to accelerate the period of training leading to independenceleading to independence
ESI PolicesESI Polices• NOT-OD-08-121 (September 2008)NOT-OD-08-121 (September 2008)–Set the definition of NI and ESISet the definition of NI and ESI
NI: NI: PD/PI who has not yet competed successfully PD/PI who has not yet competed successfully for a substantial, competing NIH research grantfor a substantial, competing NIH research grant
ESI: ESI: NI within 10 years of completing his/her NI within 10 years of completing his/her terminal research degree or is within 10 years of terminal research degree or is within 10 years of completing medical residency (or the equivalent)completing medical residency (or the equivalent)
• NOT-OD-09-013 (October 2008)NOT-OD-09-013 (October 2008)–Set expectations for FY2009:Set expectations for FY2009:
New and established investigators to be New and established investigators to be supported at equivalent success ratessupported at equivalent success rates
Majority of NIs to be ESIsMajority of NIs to be ESIs6
ESI PolicesESI Polices
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NIH strongly encourages Early Stage Investigators seeking NIH funding for the first time to apply for traditional research project (R01) grant awards, instead of applying for small grants (R03) or Exploratory/Developmental Research Awards (R21).
ESI Polices – Pioneer and ESI Polices – Pioneer and NI AwardsNI Awards
Number of New and Experienced Investigators and New Investigators as a Percentage of All Investigators on Competing R01 Equivalent Awards (FY 1990 to 2009)
New Investigators Experienced Investigators New as a Percent of All Investigators
Data from the Success Rate File December 24, 2009
New and Early Stage New and Early Stage Investigator Policy for FY Investigator Policy for FY
New and Early Stage New and Early Stage Investigator Policy for FY Investigator Policy for FY
20102010
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For All ESI A0/A1/A2 For All ESI A0/A1/A2 Applications Applications ESIESI
Payline:5 percentile points Payline:5 percentile points above the regular R01 A0 above the regular R01 A0 payline, regardless of the payline, regardless of the
amendment status of the ESI amendment status of the ESI applicationapplication
YesYes
Expedited Review:to resolve Expedited Review:to resolve comments in the summary comments in the summary
statement if >5 but <=10 statement if >5 but <=10 percentile to resolve percentile to resolve
comments in the summary comments in the summary statement if >5 but <=10 statement if >5 but <=10
percentile percentile
YesYes
Duration of GrantsDuration of Grants
Funded Funded for all for all years years
recommrecommendedended
ESI Extension ESI Extension ImplementationImplementationNOT-OD-09-034 (December 2008)NOT-OD-09-034 (December 2008)
–Set process for requesting an extension of Set process for requesting an extension of the ESI 10-year periodthe ESI 10-year period
–Established web based application formEstablished web based application form–Described factors to be consideredDescribed factors to be considered–Frequently Asked Questions developed Frequently Asked Questions developed http://grants.nih.gov/grants/new_investigators/investigator_policies_faqs.htmhttp://grants.nih.gov/grants/new_investigators/investigator_policies_faqs.htm
–First extension requests received on January First extension requests received on January 16, 200916, 2009
–First meeting of ESI Extension Committee on First meeting of ESI Extension Committee on January 21, 2009January 21, 2009
Reasons for Granted Reasons for Granted ExtensionsExtensions
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MisperceptionsMisperceptions• My tenure clock was extended by 1 year so My tenure clock was extended by 1 year so my ESI status should be extended.my ESI status should be extended.
• Clinical responsibilities associated with a Clinical responsibilities associated with a faculty appointment are eligible for an faculty appointment are eligible for an extension. extension.
• In order to be with my spouse I took an In order to be with my spouse I took an inferior research position and that should inferior research position and that should count for an extension. count for an extension.
• Time of a Career Award (K series) is eligible Time of a Career Award (K series) is eligible for extension.for extension.
• FAQs are constantly evolving to address FAQs are constantly evolving to address these and other issues. these and other issues.