Graduate Program in Molecular BioSciences: A Self Study

Graduate Program in

Molecular BioSciences: A Self Study

Prepared for Dr. Andrew Sustich, Dean of the Graduate School

by the Molecular BioSciences Program Committee

after consultation with: Dr U Dr. es

. Carole Cramer, Director, Arkansas BioSciences Institute at AS R con Johnson, Associate Chair, Department of Biological ScienDr. Greg Phillips, Dean, College of Agriculture and Technology Dr. Joh ysics

Dr. Aldemaro Romero, Chair, Department of Biological Sciences n Pratte, Chair, Department of Chemistry and Ph

Dr. Andrew Sustich, Dean, Graduate School and Interim Dean, College of Science and Mathematics

Members of the Molecular BioSciences Program Committee

Dr. Roger Buchanan, Director Graduate Program in Molecular BioSciences Dr. Anne Grippo, Associate Director Graduate Program in Molecular BioSciences

Dr. Maureen Dolan (at‐large member) Dr. Beth Hood (representing the College of Agriculture and Technology)

Ms Taylor Ingle (student member) Dr. Ron Johnson (representing the Department of Biological Sciences)

Dr, Argelia Lorence (representing the Department of Chemistry and Physics) Ms Maria Isabel Ferrand Malatesta (student member)

Dr. Fabricio Medina‐Bolivar (at‐large member)

March 2, 2009

Graduate Program in Molecular BioSciences Self Study 3/02/09

Table of Contents

History of the Molecular BioSciences Program ` Page 3 Present Structure of the Molecular BioSciences Program Page 5 Goals Objectives and Activities Page 7 Curriculum and Degree Requirements Page 16 Student Recruitment, Admission and Retention Page 18 Faculty Page 21 Intellectual Property Page 26 Program Resources Page 27 Program Assessment Page 30 Recommendations Page 33 Content of Appendices Page 41

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HISTORY OF THE MOLECULAR BIOSCIENCES PROGRAM

A committee comprised of representatives from several colleges and departments was assembled in 2004 to begin exploring the potential for a graduate program in Molecular BioSciences. In 2005, Dr. Tom Wheeler (then Dean of the Graduate School) was charged with developing a proposal for submission to the Arkansas Department of Higher Education (ADHE) seeking their approval of a terminal, research-based multi/cross-disciplinary PhD granting Molecular Biosciences Program (MBS). This effort was led by Dr. Hector Flores (then Dean of the College of Science and Mathematics) and Dr. Greg Phillips (Dean of the College of Agriculture and Technology) and the proposal was reviewed by an external panel of experts. The resulting proposal was reviewed by a panel of outside experts before submission to the ADHE in early 2005. Because redundancy of program offerings by the Institutions within the state is a major concern for the ADHE, and that programs in Molecular Biology already existed at two AR institutions (UAMS and U of A) it was critical that ASU position this program so that it was distinctive from those existing programs. Therefore the strategy of developing a program that was not just focused on molecular biology but that was administratively positioned to build on existing and planned strengths in other disciplines was a cornerstone of that proposal. Therefore the proposal to the ADHE defined the program as

“…an interdisciplinary Doctor of Philosophy degree program in Molecular Biosciences to begin in August of 2005... This will be an interdisciplinary program integrating the knowledge and technical skills of several disciplines in the science and techniques related to biotechnology.”1 “The University receives applications from many highly qualified graduate students who seek advanced training and degrees in a field such as that proposed. However, most faculty members are limited to offering degrees within their highly defined, specialized discipline or commodity-based departments. This "specialized" degree may not always be most suitable for an applicant who desires training in a more generalized field of research. Indeed, the more generalized training received in an interdisciplinary degree program is better suited to changing either the research realm (that is, target species or area of work) or model in subsequent research efforts. The students in an interdisciplinary graduate program would receive broad training and receive a degree that is more translatable to other fields of interest. Cell Biology is a broad area of interest that covers not only basic but applied sciences. Molecular Biology is not only an area of research but also a tool used in research in many different fields. Molecular Biosciences is an area that encompasses these other fields, providing a means to unite researchers from different disciplines for educational purposes as well as common research efforts. Moreover, the field of biotechnology requires graduates capable of cross-disciplinary thinking. Students will, therefore, receive excellent training and be afforded a degree that suits their needs in an area that is part of the rapidly expanding field of biotechnology.”2

1 From Proposal for a New Academic Program “Doctor of Philosophy in Molecular BioSciences” to the ADHE (updated Jan 10, 2005) p 1. 2 Ibid, pg. 5.


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“There are similar doctoral programs at other ABI partner institutions, but each has a distinctive focus. The Cell and Molecular Biology doctoral program at UAF has a strong focus on agricultural animal systems, such as poultry. The Biochemistry and Molecular Biology doctoral program at UAMS focuses on biomedical systems. The proposed Molecular Biosciences program at ASU will focus primarily on plant biotechnology systems - including graduate training emphases on plant-made pharmaceuticals, nutriceuticals, and molecular diagnostics tools for food science - but with sufficient breadth of training to permit students to understand animal and biomedical systems as well. The ASU program will complement the existing doctoral programs at UAF and UAMS...”3

From the outset, this program was fully integrated into and carefully aligned with the mission of the University, the state of AR and the ABI mandate. For example:

“The University is continuing to expand its research and teaching capacities and is continuing to recruit and hire new faculty members in this area, primarily 'in the College of Agriculture, the College of Sciences and Mathematics and the ABI Research Center. Taken together, the increased need for trained Molecular and Cell Biologists in Arkansas and nationally has made it apparent that degree programs are required to foster interdepartmental and intercollegiate graduate student training and research. The proposed doctoral program in Molecular Biosciences at ASU will serve both state economic development and student educational needs.”4

As the discussion with the ADHE proceeded the argument that this program was vital to the development of high-tech, crop and food related industries in the agriculturally intensive landscape of northeastern AR was a critical factor in securing their approval of the program. Thus the multi/cross-disciplinary foundation of this program and its connection to agriculture and the food industry have been cornerstones from the very beginning. The proposal was reviewed and accepted by the ADHE and began in August 2005. The first Director of MBS was Dr. Tom Wheeler, then Dean of the Graduate School. He was assisted in implementing the program by an advisory committee comprised of representatives from the Arkansas BioSciences Institute (ABI), the Colleges of Agriculture and Technology and Science and Mathematics and the Department of Biological Sciences and Chemistry and Physics. The first two students were admitted to the program in Jan, 2006. In 2006 a search for an outside Director of the MBS Program resulted in the appointment of Dr. Pamela Weathers (Worcester Polytechnic Institute, Worcester, MA) as director. She was charged with establishing courses, establishing policies, recruiting faculty and students and acquiring funding to support the program. She was assisted by Dr. Anne Grippo, Assistant Program Director, and a half-time staff assistant (Ms Marty Wolfe) and supported by an advisory committee that included representatives of the Colleges of Agriculture and Technology, and Science and Mathematics (Deans Greg Phillips and then Associate Dean Jerry Farris) the Arkansas BioSciences Institute (Executive Director Carole Cramer), the Office of Organized Research and Technology Transfer (then led by Associate Vice Chancellor Elizabeth Hood) and representatives of the departments of Biological

3 Ibid. pg. 4. 4 Ibid. pg. 2.


Science (Drs. Roger Buchanan and Anne Grippo) and Chemistry and Physics (Dr. Robyn Hannigan). Drs. Weathers and Grippo worked with the advisory committee to develop core courses, institute guidelines for student admission and progress through the degree program, recruit students and write a student handbook. In July 2008 Dr Weathers returned to her position at Worcester Polytechnic Institute and an internal search for her replacement began. After consultation with interested faculty from several colleges (including Agriculture and Technology, Science and Mathematics, and Engineering), the Chairs of the Departments of Biological Sciences and Chemistry and Physics and that Vice Chancellor for Academic Affairs and Research, Dr. Roger Buchanan was selected as program Director. He began serving in that capacity in September, 2008 as a half-time appointment. Thus, this program is in its infancy—just entering its fourth year. From the very earliest stages of planning this program was conceived as being a multi/cross-disciplinary program that could support any faculty member from any academic or research unit who was interested in working with graduate students in the broad field of Molecular BioSciences. The program now has 16 students, and is supported by an active and involved faculty. From the beginning, this program has, by design, been positioned to maximize its multi/cross-disciplinary mission by incorporating the expertise of faculty from several academic units.

PRESENT STRUCTURE The Director: The MBS program is directed by a Program Director appointed, after consultation with faculty and administrators in the College of Science and Mathematics (Associate Dean and Chairs of the Departments of Biological Sciences, and Chemistry and Physics), and the Vice Chancellor for Academic Affairs and Research, by the Dean of the College of Agriculture and Technology. The Director has a primary half-time (12 month) appointment as director, while the remaining 50% of his appointment is as a member of an academic department. The latter commitment may be “bought out” using grant funds, 80% of which are forwarded by Academic Affairs to the department. The position of the director within the “chain of command”, his responsibilities to the Department holding his academic appointment, and procedures for evaluating the Director’s performance are carefully and fully delineated in the current Director’s letter of appointment.

“As MBS Director, you will report to and through the Dean’s office in the College of Agriculture & Technology. However, the Dean of Agriculture & Technology will coordinate program policies, program assessment, and MBS Director annual evaluations with the Dean of Sciences & Mathematics and the Executive Director of ABI due to the shared multi/cross-disciplinary nature of the MBS program. The Dean of Sciences & Mathematics also will coordinate with the Chair of Biological Sciences for your annual evaluations.” “You currently have extramural grants to buy-out your teaching time in Biological Sciences, which we hope and expect to continue. Your individual PI grants will continue to flow through Biological Sciences (e.g., INBRE-- IDeA Network of Biomedical Research Excellence)…” “You are encouraged to maintain at least a minimal presence in the classroom on an annual basis. This may be accomplished via a team-taught course(s), or a new

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course you may develop on behalf of the MBS program. In the event that your research buy-outs decline significantly, you may be obligated to teach one or two courses for Biological Sciences.”5

Because this program is fundamentally multi/cross-disciplinary this arrangement provides direct oversight of the program (and the director) while providing a mechanism by which other academic units interested in the MBS program can have significant input at an appropriate administrative level to adequately supervise and direct this program. The current Director has also made a practice of regularly consulting with the chairs, deans and directors of the academic units (Colleges of Agriculture and Technology and Science and Mathematics, Executive Director of the ABI, Dean of the Graduate School and Chairs of the Departments of Biological Sciences, Chemistry and Physics) that contribute most heavily to the MBS program. In fact, the advice and input of the heads of those units was sought before preparing this report. Advisory Committee: The director is supported by an Advisory Committee comprised of the Deans of the Colleges of Agriculture and Technology and Science and Mathematics, the ABI Director and the Dean of the Graduate School. This committee is responsible for the overall direction of the program, to ensure that the program is adequately meeting the needs of its constituents, regardless of academic affiliation and to ensure that the program is positioned and acting in accordance with the University mission and priorities. Program Committee: The function of the Program Committee is to provide day-to-day direction to the program. This includes setting policies and making decisions relevant to curriculum, student issues, student acceptance, assignment of student stipends, recruiting, publicity, budgeting, etc. The program committee is designed to allow MBS faculty and students and academic units interested in MBS maximum input into program direction and policies. Thus, it is comprised of departmental representatives appointed by the Chairs of the Departments of Biological Sciences, Chemistry and Physics and the Associate Dean of the College of Agriculture and Technology. Two at-large members are selected by the MBS faculty and two students are selected by MBS students. The Associate Director of MBS is also a member of this committee. This composition insures that the program can be informed by the departments in which its faculty are housed and that it can be responsive to the needs of students and faculty. This committee was formed in Dec 2008 and has just begun assessment, review and, as necessary, revision of all aspects of this program6. Faculty: Because this is a young program, the requirements for being a member of the MBS faculty are not yet well-defined. This is by design. In keeping with the goal of establishing a program that is available to any faculty member interested in MBS and having the necessary background and resources to support MBS student research, requirements for inclusion in the MBS faculty are minimal. Our experience with the multi/cross-disciplinary Graduate Program in Environmental Sciences program (EVS) 5 Quoted from the assurances letter presented by Dr. Greg Phillips to Dr. Roger Buchanan, current director of the Graduate Program in Molecular BioSciences. 6 Because this review is in process some of the statements in this document represent the results of that review but have not yet been incorporated in written documents (e.g. the student handbook). The process of updating documents to reflect results of policy review by the Program Committee will be completed before the beginning of the Fall 2009 semester.


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suggests that this will be a temporary arrangement and that as MBS matures, more definitive requirements for inclusion in the faculty will become appropriate. For purposes of clarity and accurate reporting this study divides MBS faculty into two groups. The first is the “Core faculty”—defined as faculty members who are now mentoring students in the program, teach one or more core courses or serve on the program committee. “Associated faculty” are those who, during the process of designing this program, elected to associate themselves with the program, or who are newly recruited faculty whose training and research interests are consistent with MBS goals. Associate faculty do not have students in the program or teach any of the MBS core courses, however a few of them serve on dissertation committees or teach elective courses. Based on our experience with the more mature, but similarly designed EVS program, most of these individuals will either recruit students and remain involved with the program or will pursue other interests and become involved in other programs. While this governing structure and definition of “program faculty” differ in several important aspects from traditional academic structures, it is an excellent mechanism for developing and supporting multi/cross-disciplinary programs. The shared governance of the program and optional involvement of faculty members from a number of disciplines allows academic units to inform the direction of and develop “ownership” of the program while using the program to supplement and strengthen their units. It allows faculty and academic units to take advantage of collaborative and co-operative opportunities with individuals from many different disciplines, provides maximum flexibility in training and recruiting students and is an excellent training experience for students as it ensures that their training will be truly multi/cross-disciplinary. For example, a student with a background in agriculture who are interested in genetic engineering of plants to enhance their agricultural utility are attracted to and comfortable in this program, while they might be much less likely to consider a program housed in a biology department. Similarly students with a biochemistry background interested in studying metabolomics, who would not ordinarily be interested in a program housed in agriculture, are able to find a home in this program.

GOALS, OBJECTIVES, AND ACTIVITIES Mission Statement: Molecular Biosciences is a multi- and cross-disciplinary field that is revolutionizing discovery and technological advances in disciplines ranging from agriculture to medicine, from forensics to environmental sciences, from food sciences to renewable energy. The Molecular Biosciences Graduate Program (MBS) provides training and research opportunities that integrate cellular, molecular, developmental, biochemical and genomic information and knowledge that are available to students and faculty whose research interests are compatible with these disciplines regardless of academic affiliation or background. The program has a strong emphasis on multi-, cross- and interdisciplinary approaches, state-of-the-art technologies and innovation to address real world problems. MBS and the mission of Arkansas State University: The “Strategic Plan for Academic Affairs and Research”7 directing strategic planning for the University includes several institutional priorities to which MBS directly contributes. For example: Priority

7 Presented by Dr. Dan Howard, Vice Chancellor for Academic Affairs and Research to the Academic Affairs and Research Council on Dec, 8, 2008. The text of this document is included in Appendix G


1.1.3 “Provide increased opportunities for service learning, research, and scholarly activities outside the classroom” at the graduate level, MBS is clearly a key contributor to this priority. Graduate training in a research-based program MUST provide opportunities for research and scholarly activities outside the classroom for student and faculty participants. In addition MBS faculty are heavily invested in “outside the classroom” education of undergraduate (and even high school) students. At present there are over 50 undergraduate and high school students involved in MBS-related research projects. MBS is also a significant contributor to Priority 1.4.4 “Develop a strategy for establishing and maintaining Centers of Excellence”. MBS students support research in the Center for BioFuels and BioBased Products and in the Remote Detection of Volatile Chemicals Laboratory. These projects are, by definition, multi/cross-disciplinary efforts consistent with the MBS mission and enhanced by the participation of MBS students. As ASU develops additional research centers, MBS students and participating faculty are ideally positioned to assume leadership and supporting roles. The MBS program also contributes significantly to priority 2.1 “Globalize the University under the Complementary Themes of ‘Bring the World to ASU’ and ‘Take ASU to the World’ ". The student body of the MBS program is one of the most diverse on campus. The director works closely with the Office of International Programs to enhance recruitment of international doctoral students. This effort has been successful, 10 of the 16 MBS students are International Students. Those students are mentored by 9 faculty members, 5 of whom are international faculty. Thus, although still small, diversity has been and will remain a focus of MBS thereby making a significant contribution to this priority. Probably the most significant contribution of MBS to ASU priorities is to Priority 2.2 “Transform Arkansas State University into a More Research Intensive and Globally Prominent University”. Extramural grant funding awarded to MBS faculty has grown from ~$2,000,000 in 2006 to ~14,000,000 in 2009 (to date). (These data are presented more fully below and in Appendix D). Though still a very young program, MBS has already proven to be a major engine for increasing grant funding at ASU and for raising ASU’s institutional profile. Every MBS faculty member who directs a dissertation is already linked to other institutions within the state by their involvement in multi/cross-disciplinary, multi-university research teams. Several MBS faculty are involved in similar national and International teams. MBS students and mentors are strongly encouraged to include researchers from other institutions in student dissertation committees, and all do. This alone enhances ASU’s reputation as science faculty at other institutions become intimately aware of the quality of faculty, students and research being done in MBS and on the ASU campus. ASU faculty’s ability to compete successfully for statewide and national funding has been significantly enhanced in recent years. While this is the result of significant efforts by several units, the MBS is a key player in this effort as it provides a home for a key component of any University research program—quality graduate students. The significance of the multi- and multi/cross-disciplinary foundation of MBS to this effort cannot be overstated. Much of modern scientific research depends on answering questions that can only be addressed by multi- and multi/cross-disciplinary teams of researchers. Federal and state funding agencies make no secret of their emphasis on such teams and efforts. MBS’s dedication to supporting and fostering this kind of research is crucial to continued growth of research resources at ASU.

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MBS is also a significant contributor to Priority 2.2.2 “Identify and pursue graduate programs that have the potential to be high demand and cost effective”. The rapid growth of MBS and the increase in funding awarded to active MBS faculty are testaments to the demand and need for this program. The MBS budget is very small; therefore nearly all the funding that supports student and faculty research is derived from grants. This is a significant strength of the MBS program and is discussed in more detail below. Lastly MBS emphasizes entrepreneurial activities by students and faculty, including (in co-operation with the College of Business) development and delivery of entrepreneurial courses to ASU students. These contributions are discussed in more detail below, and directly support Priorities 3.2.5 “Develop and budget infrastructure to support entrepreneurial technology transfer to commercial application” and 3.2.6 “Develop a model to train and equip science and technology areas with entrepreneurship capability”. In summary, MBS is fully integrated into and already is making significant contributions to the University’s mission and strategic plan. Several key components of that plan are recognized as being crucial to the MBS mission. MBS contributions to realizing the University’s strategic plan can reasonably be expected to increase as the program grows and matures. Definitions: As a discipline, Molecular Biosciences “can be viewed as a dynamic continuum in which approaches derived from chemistry, physics and biology address fundamental mechanisms of living things.”8 Molecular Biosciences encompasses the disciplines of cell and molecular biology, biochemistry and biophysics. It is the study of various aspects of cell function, structure, metabolism, and chemical functions on, within, and between cells, the study of biomolecular interactions, the relationships between biomolecular reactions and observed cellular properties, molecular genetics, protein chemistry, and biological structures, as well as the use of molecular detection methods to detect or characterize biological states in animal and plant sciences, systematics, forensics and health care. Cell Biology and Molecular Biology are the fundamental bases for biotechnology and are expanding areas of research. Thus, rapid growth has sprung out of the biotechnology revolution which has affected state, national and international aspects of agriculture, life sciences, human health, and commercial enterprises. Molecular Biosciences is fundamental to many fields of endeavor and careers in today's knowledge-based economy, with a focus on the interfaces between agriculture, biochemistry and medicine, including: discovery and production of pharmaceuticals, diagnostic tools in food science, nutrition and public health, environmental sciences, bioinformatics, biodefense, education and science literacy, forensics, archeology, and the genetic basis of modern agribusiness. MBS as ASU addresses classical and contemporary problems in biology through creative integration of biochemical, cellular, molecular, developmental and genomic information and techniques. As such it has both multi- and multi/cross-disciplinary features that support research topics in Molecular Biosciences including the study of biomolecular interactions, dissection, engineering and design of metabolic pathways, effects of environmental stimuli on molecular and genetic responses, discovery and development of novel biomaterials, development of methods for molecule detection and

8 http://molecular.biosciences.wsu.edu/

http://molecular.biosciences.wsu.edu/


diagnostics, and tools for bioinformatics, and genetic engineering technologies. As such, Molecular Biosciences contributes fundamental knowledge contributing to the basis for biotechnological applications, including novel biological patents. . Goals: The overall goal of this program is to train graduate students who are able to excel at the highest levels of academia, government and industry. To accomplish this goal, MBS strives to become competitive nationally and internationally, capable of attracting the highest quality students, productive and creative faculty who together are able to successfully compete for national research funding. This program seeks to meet a well-established need for broadly based and interdisciplinary technical training of graduate students who contribute to state, regional and national needs in the coming years. Specifically our goal is that students earning the Ph.D. degree from MBS will compete successfully for top postdoctoral research positions in both academia and industry and/or become employed by universities, industry, and federal and state research agencies. Specifically, students earning the Ph.D. degree at ASU in Molecular Biosciences will:

1) Master theoretical aspects within the linked disciplines of chemistry, biology, physics, computer science and agriculture.

2) Devise and complete independent research that culminates in the preparation of a written dissertation of novel scientific value.

3) Demonstrate the ability to approach scientific problems in an hypothesis-driven manner, employing state-of-the-art experimental approaches.

4) Communicate effectively, orally and in writing, the overall significance of their independent scientific research.

5) Compete successfully for top postdoctoral research and/or teaching positions in both academia and/or industry.

Student learning: One of the important goals of this program is to provide students with broadly based, multi- and multi/cross-disciplinary technical training based on the disciplines of cell and molecular biology, biochemistry and informatics. These disciplines are central to Molecular Biosciences so graduates of this program must have the knowledge and skills needed to become leaders in these fields. One of the central strategies adopted by this program to achieve this goal is that students become participating members of multi- and multi/cross-disciplinary research teams focused on addressing important questions that can only be answered using molecular biosciences techniques. To achieve this goal we have assembled a group of diverse faculty from a wide variety of disciplines and academic programs. This diversity of faculty interests is critical to training students in this program. Maintaining a faculty and student body characterized by ethnic, racial and gender diversity is also crucial to the success of this program. We also emphasize involvement of faculty in entrepreneurial activities needed to support economic development in the region and state. Students are encouraged to be active in this endeavor. Research: This program seeks to incorporate a wide variety of faculty and student research interests. Although we have developed a focus on plant molecular biology as a distinctive strength, MBS, while in its infancy already incorporates a wide variety of research interests. Faculty whose interests range from analytical chemistry,

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neuroscience, psychology and computer science have all found a research home in this program. Entrepreneurial emphasis: ASU is uniquely located and positioned to promote economic development in Northeast Arkansas. The strengthening of the state's economy is envisioned by the Arkansas Department of Economic Development to involve expansion of knowledge-based industries that require a well-educated workforce. The innovations that feed the expansion of knowledge-based industries arise through basic and applied research endeavors fueled by university faculty and graduate student research programs. Intellectual property that supports industry expansion and development of research innovations arises primarily at the highest ends of the educational system, i.e., through graduate research and especially doctoral student research. MBS is dedicated to meeting the challenge of achieving economic development outcomes fueled by university research innovations and education of the knowledge-based workforce. The symbiosis of the state-wide Arkansas Biosciences Institute (ABI) system, the academic programs already available at ASU and MBS is envisioned to lead to the spin-off of new companies in eastern Arkansas and the Delta region, powered by regional Arkansas residents who have received their educational training at ASU. By combining economic development with community development (educational training of regional students), these spin-off companies are more likely to persist within the region over time. Agriculture and food processing are the mainstays of the existing economy in eastern Arkansas, and ASU has a long tradition of educating regional residents involved in agribusiness. MBS enables ASU to expand its role in the region as an engine for economic development. Objectives The program is in direct support of the state of Arkansas mandate to Arkansas State University. Historically, MBS has been closely associated with the state's ABI mandate9 and funding. However, MBS is a logical extension of recent ASU faculty recruitment and increased focus on Molecular Biosciences at the department and college levels, and is available to any faculty member, regardless of academic affiliation, whose research is compatible with the MBS mission. MBS is also envisioned to support the development of technology intensive industries in northeast Arkansas. As such, a major focus of dissertation research is on plant-made pharmaceuticals, nutriceuticals, industrial products and other high-value modifications of plant products through metabolic engineering, and molecular diagnostics for food science through

9 The creation of the Arkansas Biosciences Institute (ABI) by statewide referendum in 2000 provided funding from AR share of tobacco settlement dollars and statewide support for the mission of integrating research, education and economic development, and strongly indicates the support of degree programs to meet the challenge at each of the partner institutions: "The mission of the ABI is to improve the health of Arkansans through biomedical and agricultural research initiatives. ABI will become recognized internationally as a leader in health and life sciences research. Its multifaceted programs will strengthen Arkansas through science-based economic, development including research, education, and technology." ASU is one of the five state institutions mandated and funded to advance the ABI mission. The other institutions are the University of Arkansas for Medical Sciences (UAMS, Little Rock), the University of Arkansas, Division of Agriculture (Fayetteville), the Arkansas Children’s Hospital (Little Rock), and the University of Arkansas (Fayetteville). Two research buildings were constructed to meet this mandate. One was located on the campus of UAMS and the other at ASU. In order for ABI to meet its statewide mandate, ASU is the partner ABI institution mandated to serve eastern Arkansas and the Delta region, the region of the state in most need of economic development expansion. The establishment of the ASU-ABI has already resulted in the relocation of two plant biotech companies to Northeast Arkansas, with additional start-ups anticipated as a result of ABI activities in the coming years.


biotechnology. This research training focus complements the strengths of other graduate institutions in the state and region, our partner institutions in the ABI consortium and ASU's existing masters programs. As discussed in more detail above, ASU’s strategic priorities are consistent with the MBS mission, goals and objectives. The MBS director, advisory and program committees are charged with insuring all MBS activities are aligned with those priorities. Overview of Activities Teaching; MBS offers a set of required “Core courses” designed to be taught without prerequisites to ensure that all students entering the program have an adequate foundation in disciplines fundamental to the Molecular biosciences. These courses are taught almost exclusively by ABI faculty who actively support the program in this way. A broad selection of elective courses is also available. These courses are regularly scheduled courses offered by academic units in the Colleges of Agriculture and Technology and Science and Mathematics in support of their majors. Research: As a terminal, research-based degree, MBS is a research intensive program. All students are required to complete an intensive, research project that is supervised by a multi/cross-disciplinary committee, presented to and reviewed by peers and defended before receiving their degree. All MBS faculty are expected to develop extramurally funded research programs capable of supporting their students. Support: The University offers wide-ranging support to all graduate programs and students. These include the library, the Office of International Programs the Graduate School, student Counseling services, information technology services (ITS) and support of too many other campus programs and units to be described in detail here. MBS is supported by a half-time staff assistant. This assistant is shared by the other multi/cross-disciplinary science graduate program (Environmental Sciences). She is responsible for support for the MBS Director, faculty and students and assists in a wide variety of activities from secretarial support, to course scheduling, coordinating student record-keeping, budgeting and procurement. All MBS faculty and students, regardless of academic affiliation, have access to quality research space and instrumentation. The funds to purchase most of the equipment and instrumentation supporting this program were provided by the ASU ABI and have been supplemented by grant funds secured by MBS faculty members. MBS is also supported by a Science Seminar Series where scientists from all disciplines are invited to present their research. Most of the speakers in this seminar series are from off campus. The seminar series is supported by funds from the ABI, ASU and NIH (AR INBRE). Further support is provided by two research groups; a plant molecular biology group and an animal biology group that meet biweekly. Nearly all MBS faculty and students participate in one or both of these groups. The function of these groups is to provide a forum where research results and plans, in progress grant proposals, new technologies, and student and faculty presentations can be discussed with interested colleagues, researchers and students. These groups are excellent training grounds for MBS students who regularly present their research results and plans to a supportive but critical audience.

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MBS is also supported by the Office of Research and Technology Transfer (ORTT) led by Associate Vice Chancellor, Dr. Michael Dockter. This office not only provides pre-award administration, but also is responsible for assisting in the development of protectable intellectual property. This office is also responsible for the ASU IACUC and IRB and the ASU institutional BioSafety committees that insure compliance with applicable regulations for animal- and human-based research and research dependent on recombinant DNA technology and genetically modified organisms. The Office of Grants and Contracts (Division of Finance and Administration, led by Ms Renita Gray) is responsible for post award administration and is available to assist MBS faculty in developing budgets and supervising expenditures of awards. Other post award support is provided by the staff of academic units and the ABI. ASU Procurement services assists in the purchasing of supplies and equipment. Budget: The 2008-2009 MBS budget is:

$16,628 (50% Staff Assistant) plus $4,988 (fringe benefits) $5,000 Supplies

In addition ASU provides 4 12 month graduate student stipends ($18,360 each). These are budgeted through the Graduate School. The ASU ABI provides an additional 6 stipends. Thus the total available for student stipend support is $183,600 per year. At the beginning of the fall 2008 semester there were 14 students in the program. ASU (Graduate School and ABI) provided $112,770 in student stipends, $122,470 of student stipends were supplied by grant funds (one student is ABD and does not require stipend support). Three more students entered in spring 2009, one of those students is supported by ASU funds, another’s support is 50% ASU/50% grant and the third student’s support is 100% from a grant. Demand for this program: According to the US Department of Labor the category of "Biological and Medical Scientists" employed about 138,000 professionals in 2000, with an anticipated 21-35% increase (roughly 28,000 to 48,000 new jobs in the US) by 2010. The Ph.D. degree is strongly encouraged in this area as having the strongest growth potential and advancement opportunities. According to recent US Department of Labor statistics, there is a projected increase of 20-35% in the demand for advanced degree positions in the agricultural and biopharmaceutical industries over the next 10 years. This demand is supported by additional statistics indicating a projected 20% increase in salaries for these positions over the same time period. Graduates from this program will help to meet this projected highly-educated workforce need in biotechnology related areas. In 2000 up to 17% of medical scientists and 40% of biological scientists worked for government agencies (federal, state, and local). The remainder was employed by pharmaceutical and biotechnology industries, research and testing laboratories, educational institutions, and hospitals. Graduates from this program are needed as research and development scientists to staff new biopharmaceutical companies that are expected to locate or originate in Arkansas as a result of technology transfer from ASU and other state institutions. As such, this program will have a direct positive effect on economic development in Arkansas. Student demand for this program: At present are 16 students in the program. Five applications for the 09-10 academic year have already been processed and there are

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three other applications pending (See Table 1). This table shows a continued increase in the number of applicants to the MBS program each year. The applicant pool has more than doubled between fall 2007 and fall 2009. This is consistent with the goal of achieving an enrollment of 15-20 students within 5 years of the beginning of the program. There has been an encouraging and steady growth in the number of inquiries and applicants to this program. There is no reason to expect this growth to abate. Because of its multi/cross-disciplinary nature, MBS can be central to faculty and student recruitment by a number of academic units. Since growth in research and research funding is a University priority, MBS is poised to make a significant contribution to this effort. Already several academic programs have used the existence of MBS at ASU as a powerful recruiting tool and have been able to attract active junior faculty members who contribute simultaneously to their academic units and to MBS. Research funding acquired by MBS faculty has grown significantly since the inception of the program. This trend is expected to continue as quality research programs capable of attracting funding from a number of sources continue to develop, and as ASU evolves into a more research intensive institution as it strives to meet the stated goal of achieving $100M in research funding within 10 years, and as the research profile of the institution, its programs and its faculty continues to grow.

Table 1: Applicants, Admissions and Class Size since the Inception of MBS

Academic Year

Number of Students (Data as of 2/10/09)

Inquiries Applications Accepted Cumulative

Class Size

Graduates

Spring ‘06 unknown 3 2 2 none

Fall 2006 unknown 5 2 3 none

Spring 2007 unknown 6 3 5 none

Fall 2007 20 8 6 11 none

Spring 2008 27 5 1 11 none

Fall 2008 52 10 6 14 none

Spring 2009 44 18 5 16 ???

Totals 143 55 25 16

Note 2 students have withdrawn from the program, 1 was dismissed in spring 2008, a 2nd withdrew at the beginning of the fall 2008 semester.

Student Progress: Because MBS has not yet produced graduates, Table 2 is included to show that steady progress toward their degree is being made by each student in the program. Based on these data we project that the first MBS students should graduate during 2009 and that the program will have no trouble meeting the ADHE requirement or 2 graduates per year (over a 3 rolling average) for minimum number of graduates to demonstrate viability. The program presently serves a diverse group of students coming from the local region, throughout the state of Arkansas, and the nation. In addition, a sizeable percentage of our students are international students.

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Student Advisor Entry

Committee POS Qualifier Proposal Defense

Core Complete

Candidacy Dissertation Defense

Taylor Ingle Buchanan Spring ‘06 Yes Yes Spring ‘09 Spring ‘09 Yes Fall ‘09

Katherine McKeon‐Huber Buchanan Spring ‘06 Yes Yes Yes Yes Yes Yes

Spring or Summer ‘09

Sangwoong Yoon Hood Fall ‘06 Yes Yes Yes Yes Yes Fall ‘09

Audrei Dabul Hood Spring ‘07 Yes

Guillermo Trujillo Lorence Spring ‘07 Yes Yes Spring ‘09 Yes Yes Fall ‘09

Walter Acosta‐Gamboa Cramer Fall ‘07 Yes Yes Yes Yes Yes Fall ‘09

Jose Condori Medina‐Bolivar Fall ‘07 Yes Yes Yes Yes Yes Fall ‘09

Siddique Imran Lorence Fall ‘07 Yes Yes Spring ‘09 Spring ‘09 Fall ‘09

Caser Nopo‐Olazabel Medina‐Bolivar Fall ‘07 Yes Yes Yes Spring ‘09 Yes Fall ‘09

Timothy Ashby Huang Summer ‘08 Fall ‘09 Fall ‘09

Maria Ferrand Dolan/Medina‐Bolivar

Fall ‘08 Fall ‘09 Fall ‘09

Katherine Lisko Lorence Fall ‘08 Fall ‘09 Fall ‘09

Seth Schirmer Srivatsan Summer ‘08 Fall ‘09 Fall ‘09

Madhumita Paul Srivatsan Spring ‘09 Spring ‘10 Spring ‘10

Kenton Leigh Buchanan Spring ‘09 Spring ‘10 Spring ‘10

Zhiqiang Zhoa XU Spring ‘09 Spring ‘10 Spring ‘10


CURRICULUM AND DEGREE REQUIREMENTS The MBS curriculum is designed to prepare students for independent research careers in Molecular Biosciences. By its very nature, this is a multi- and multi/cross-disciplinary program that currently involves aspects of chemistry, biology, physics, computer science and agriculture. The MBS curriculum is designed to provide the academic basis from which all graduates can achieve the goals described above. All candidates for a Ph.D. degree in Molecular Biosciences are required to complete or have completed the specified core courses. They must also complete a set of elective courses, or their equivalent, as directed by the student's Doctoral Advisory Committee. All candidates must attend every Molecular Biosciences Seminar (at present this is the Science Seminar Series described above) when in residence on campus. Each Ph.D. student must complete a minimum of 13 hours of Molecular Biosciences approved course work (including the specified 9 credits in Core Technical courses, 1 credit in Responsible Conduct in Research and a minimum of 4 credits from the Techniques in Molecular Biosciences course). Students must also take the Seminar in Molecular Biosciences every semester plus a minimum of 18 hours of dissertation research credits along with any other courses required by the student’s Doctoral Advisory Committee. Every student is required to complete 72 credit hrs of post-baccalaureate courses before they can be awarded the PhD. Their Dissertation Committee may alter or require additional academic work as it deems appropriate to meet the student’s specific educational needs. The committee also provides a written plan of study by semester for each student. MBS Courses:

MBS Core Courses required of all MBS Students (10 hrs) MBS 6213 Advanced Cell Biology (last offered spring ’09; 3 credit hours) MBS 6233 Specialized Biochemistry (last offered spring ’09; 3 credit hours) MBS 6243 Molecular Genetics and Genomics (last offered fall ’08); 3 credit hours MBS 7151 Responsible Conduct in Research (last offered fall ’08; 1 credit hour)

Supplementary Courses required of all MBS students (27-28 hrs min) MBS 6251-3 Techniques in Molecular Biosciences (3-4 required—last offered

fall ‘08) MBS 7111 Seminar in Molecular Biosciences (required every semester, last

offered spring ‘09) MBS 8891-12 Dissertation in Molecular BioSciences (18 credit hours minimum)

Other MBS courses MBS 7121-3 Topics in Molecular BioSciences (last offered spring ’08; 1-3 credit hours) MBS 7131-3 Independent Study in Molecular BioSciences

Syllabi for these courses are in Appendix C. Degree Progression: There are a series of projects and examinations that are meant to prepare and test the student’s potential for continued success in the program (please see Table 2). The first of these is a research proposal describing the student’s

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dissertation research. This is prepared in consultation with the student’s dissertation advisor and committee. It is submitted to and reviewed by the student’s dissertation committee and must be presented in a public defense. Together these constitute the “Qualifying Examination”. This is followed by course work, extensive research, preparation, submission and review of another research proposal describing a research project different than the student’s dissertation research (the Candidacy Examination). The capstone requirement is preparation and defense of a dissertation describing the completed research. The dissertation is prepared in consultation with the student’s dissertation advisor and committee, is submitted to them for their review and approval. Ultimately the work is publicly defended. The PhD degree is conferred after the dissertation committee evaluates and approves the dissertation and its defense. Details about the requirements for each step in this progression are in the MBS student handbook found in Appendix A Table 3: Summary of Degree Requirements Event Notes and required Forms Before first semester Identify dissertation advisor (will be

assigned by the Director if necessary)

Most students enter the program having already chosen a Research advisor.

By end of 2nd semester Choose a Research Advisor and assemble PhD Advisory Committee

Submit “PhD Advisory Committee Composition” form

By end of 1st year • Program of study defined by PhD Advisory Committee

• Set date for Qualifying Exam

• Submit “Program of Study” form to MBS office

• Submit “Intent to Take Qualifying Exam” form to MBS office

During 3rd semester Research proposal to Committee; Qualifying Exam and public defense of proposal

• Defines student’s intended research; • Submit “Pass Qualifier” form to MBS

office Within 1 year of passing Qualifying Exam

Candidacy Exam and public defense

• Focused on research outside student’s dissertation research area

• Submit “Pass Candidacy” form to MBS office

In last semester Dissertation to Committee and public dissertation defense.

• Submit “Intent to Graduate” form to Graduate School;

• Submit “Intent to Defend” form to MBS office;

• Submit “Pass Defense” form to MBS office

Notes 1) Detailed descriptions of degree requirements are found in the “MBS Student Handbook”, Appendix A).

2) Projected dates for completion are suggestions. 3) Failure to meet suggested deadlines will result in review of student’s progress by the

Program Committee followed by consultation with the student’s dissertation advisor. Continued failure to make progress will result in student’s dismissal from program.

Introduction of new courses: In keeping with ASU policies governing the introduction of new courses, academic program curriculum changes are originated by the program. ASU policy is that curriculum changes for this program require approval of the MBS Program committee, the MBS Program Director, college graduate curriculum committee, dean of the college, the Graduate Council, and the Vice Chancellor for

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Academic Affairs and Research. More details about this process are included in Appendix C Curriculum review and Development: Internal curriculum review is an ongoing process. To reduce the need for regularly introducing new courses while allowing for advances in this rapidly changing discipline, several courses are designed to allow for flexibility and variability in course content. These include; MBS 6251-3 Techniques in Molecular Biosciences, MBS 7111 Seminar in Molecular Biosciences and MBS 7121-3 Topics in Molecular BioSciences. These courses allow MBS to take advantage of visiting scholars with expertise in relevant areas, topics of special interest to students and faculty and newly developing areas of investigation or interest. Techniques courses are offered by MBS faculty sometimes assisted by outside experts and are focused on teaching students specific techniques applicable to their education and research. Recent techniques courses include: “Essential Tools for Protein Analysis and Purification”, “HPLC”, “Genomics and Bioinformatics”, and “Hairy Roots: Culture and Applications”. Planned techniques courses include courses in light and fluorescence microscopy and MALDI-TOF that will be taught this summer (2009). Course content is defined by needs expressed by students and faculty and to provide training in the use and application of newly acquired equipment. To meet the requirements of the required seminar course students must attend the weekly Science Seminar series. This seminar series offers exposure to a wide variety of invited (~80%) and ASU (~20%) speakers representing a wide variety of science topics and is designed to expose students to a wide variety of cutting edge science within and without their research areas. Topics in Molecular BioSciences is a team-taught course designed to introduce students to a variety of topics. 2-3 week units are taught by MBS faculty, other faculty at ASU or researchers from other institutions. Depending on the instructors expertise these units may cover a wide variety of topics, incorporate reading of current literature and have proven useful in expanding student’s research horizons, keeping students current in advancing fields and introducing them to fertile areas of experimentation and research. Elective courses are taught by faculty in other departments and may include any graduate level courses that are deemed appropriate by the student’s dissertation committee. Typically these courses are in the College of Agriculture and Technology, and the College of Science and Mathematics. For example, students are often required to take statistics courses or courses in cell biology. However, the dissertation committee has the responsibility of requiring student to take courses that are relevant to her/his career and research goals.

STUDENT RECRUITMENT, ADMISSION AND RETENTION Recruitment: Because this is a terminal research-based degree, the most important mechanisms for recruiting quality students are the faculty who contribute to the program. The second most important recruitment feature is grant funding available to individual faculty members to support student research. There are a large number of competing molecular biology programs housed at large, prestigious institutions. Thus it is critical that MBS have distinctive features that set it apart from other potentially competing programs. At the early stages of planning for this program two such distinctives were identified;

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1) The multi/cross-disciplinary nature of this program with significant contributions from colleges and departments is foundational to this program. The ability to attract students from agriculture, biology and biochemistry (housed in different departments at ASU) has had significant impact on the growth, development and competitiveness of this program. 2) The emphasis on plant biotechnology is a distinction critical to the success of this program. While there are many molecular biology programs from which prospective students may choose, there are far fewer multi/cross-disciplinary programs offering a specialty in plant molecular biosciences. This foundation is well-supported by the ABI and the College of Agriculture and Technology who supply faculty having significant expertise in this discipline, linkages to the agribusiness in northeastern AR, as well as equipment and expertise. This has proven to be especially attractive to students from agricultural backgrounds.

The Director and faulty have engaged in a variety of activities designed to enhance the reputation and visibility of MBS. Several of these efforts have been in conjunction with the Graduate School. For example, the program director attended the annual Oak Ridge Summer Student Research Poster Session and graduate fair, attended a graduate fair in Puerto Rico and has contacted nearby 4 year institutions with information about MBS. An MBS brochure was developed in 2006 (see Appendix G) and is being assessed, reviewed, revised and updated by the MBS Program Committee. Successful student recruitment to a graduate program such as MBS is directly related to the research success and visibility of the faculty. The best students are attracted to this program because they wish to do research with one of our faculty members and faculty are able to recruit the best students as they identify students who are interested in their research. This fit between student and faculty research interests is critical to student recruitment and retention especially in the early years of a research-based graduate program. This has been, and will continue to be, our most successful recruitment strategy. Therefore, increasing the visibility of faculty and students by supporting faculty and student presentations at scientific meetings, website visibility,10 participation in scientific organizations, publications, and grantsmanship are high priorities for continuing to improve student recruitment. The availability of student stipends is also an important component of student recruitment. ASU support in the form of funded student stipends and tuition waivers has proven sufficient to allow the program to grow to its present size and is projected to allow the program to continue to grow. Generally, these funds are used to provide support students for a total of 12 months and are regularly leveraged by combining with funds from faculty grants to provide partial support for a more extended period of time. Although funds from this pool can be used to support students who need funding after the 12 months have expired, this will impact our ability to recruit new students and support new faculty seeking to establish their research program at ASU. Typically, faculty wishing to recruit and retain a graduate student must have acquired sufficient funds to support that student within a year. Usually these funds are part of the faculty

10 As this document is being written (February, 2009), ASU Information and Technology services is revising the structure of the ASU website. As a result information on many ASU web pages cannot be found by Google and other widely-used search engines. We believe this is a temporary situation that will soon be rectified.


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member’s start-up package so that most new faculty effectively have at least two years to acquire the needed funds. The availability of student stipends creates considerable demand for faculty to successfully compete for research funding. This is neither unusual nor inappropriate for a program of this type. It is doubtful that a faculty member without sufficient research funding can adequately prepare an MBS student to be successful in the highly competitive fields targeted by MBS. To date MBS faculty have been successful in competing for over $14,000,000 (as PIs awarded extramural funding) in research funding which is adequate to support the current number of students and allow for significant increases in student enrollment in the near future. However, as is the case for many science graduate programs, growth in student numbers in this program will be directly linked to successful competition for research funding. Admission Policies11: For Admission to Program: Each applicant must have a minimum of a B.S. in a basic or applied science, although preference may be given to M.S. level applicants. Applicants must present Graduate Record Examination (GRE) scores for the Verbal, Analytical and Quantitative tests. The minimum combined Verbal and Quantitative scores must be 1000. Although not required, scores from an advanced test related to Molecular Biosciences may increase a candidate's chance for admission. Prospective students must also submit three letters of recommendation, and a personal statement (maximum of two pages) describing their academic and research goals, as well as a $50 non-refundable application fee. Once the basic Graduate School application requirements are met, applications will be forwarded to the Molecular Biosciences Program Committee for review and determination of student admission and funding. The deadline for receipt of all application materials for consideration for Fall admission is February 15. For American Citizens: Visit http://graduateschool.astate.edu/application.htm. For International Students: International Student Application Information: http://international.astate.edu/International_Students.htm. The academic requirements for admission of international students are as follows:

1. The academic preparation of applicants must be the equivalent of a four-year bachelor's degree from an institution of the United States.

2. The records of previous studies must reveal appropriate standards of academic achievement.

3. Applicants must meet all Graduate School and all program admission requirements.

Applicants for admission from a foreign country must submit: 1. A completed application for admission. 2. A $50 (United States currency) non-refundable application fee. 3. Official transcripts of all school, college, and university records of the applicant.

11 Admissions policies from the MBS and Graduate School websites.

http://graduateschool.astate.edu/application.htm

http://international.astate.edu/International_Students.htm


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4. An official report of the score on the Test of English as a Foreign Language (550 or higher) unless a degree has been earned from an American institution, the native language is English, or admission to CESL is also requested.

5. A certification of adequate financial resources, at least $26,300 (U.S.) for each year, to support the individual during the period of study in the United States.

6. Students born in January 1957 or later are required to present written documentation of measles and rubella immunization. This immunization must have been received after the first birthday and after January 1, 1968.

Retention: Like student recruitment, student retention is directly related to the research success of MBS faculty, the student, the availability of student stipends and the resources available to students. To date retention has not been a problem. The two students who left the program were dismissed for academic reasons. The MBS faculty strives to create an environment that encourages and facilitates student participation in scientific meetings and publication. These activities motivate students to continue their research and are powerful factors in successful retention. The MBS Program Committee has begun assessing and reviewing student activities, and will be conducting surveys and interviews so that we can better gauge student impressions, needs and desires. This effort will be led by the student members of the MBS Program Committee and, when completed, will inform decisions and strategies for improving the development of esprit de corps and identification with MBS by our students.

FACULTY This program is highly multi/cross-disciplinary and benefits greatly from contributions of faculty from numerous departments and colleges. Most MBS Core courses are team taught by faculty from several disciplines, graduate students are mentored by faculty from several Departments and Colleges and Dissertation Committees comprised of faculty from a wide variety of academic units at ASU and other Universities. The nature of the material and research presented to our students requires this cross-jurisdictional participation. At present, our graduate students benefit maximally from this emphasis on cross- and multi/cross-disciplinary training. As described above, at present the membership in the MBS faculty members is self selected and voluntary. The responsibilities and role of each of the “Core faculty”12 are briefly described below. curriculum vitae of all faculty members associated with the program can be found in Appendix B. Director

Dr. Roger Buchanan (Appointment as Director in the College of Agriculture and Technology, academic appointment in the Department of Biological Sciences). Dr Buchanan directs the MBS program, is supervised by the Dean of the College of Agriculture and Technology. His performance is evaluated by the Deans of the College of Agriculture and Technology and Science and Mathematics (assisted by the Chair of the Department of Biological Sciences) and the Director of the ABI. He has a well-funded research program (over $6,100,000 in research funding)

12 In this report the designation of “Core Faculty” is reserved for those faculty members who teach a core course, act as a mentor for one or more MBS students or serve on the MBS Program Committee. Other faculty members who have indicated their interest in being affiliated with the MBS program are designated as “associated faculty”.


directs the shared analytical facility and mentors 3 MBS students. He teaches the core course “Responsible Conduct in Research” (MBS 7151)

Arkansas BioSciences Institute (ABI) Faculty: The primary appointment of these individuals is in the ASU ABI. As a matter of convenience for purposes of tenure and promotion, most of them hold appointments in academic departments. Their salaries are paid by from ABI funds and most are, by letter of assurance, expected to support MBS.

Dr. Fabricio-Medina Bolivar (Secondary appointment: Department of Biological Sciences). Dr. Medina-Bolivar was hired by the ABI in 2005. He teaches a core course (MBS 6233 Specialized Biochemistry), has taught MBS 6251 Techniques in Molecular Biosciences, and participated in the team taught course Topics in Molecular BioSciences (MBS 7123). He has built an extensive research program (total funding over $1,500,000), mentors 3 MBS students and is a member of the MBS Program Committee. Dr. Carole Cramer, Director of the ASU ABI. She holds secondary appointments in the College of Agriculture and Technology and the College of Science and Mathematics (Department of Biological Sciences). She has directed the team taught “Topics in Molecular BioSciences” (MBS 7123), has built a well-funded research program (total funds >$4,500,000) and mentors 1 student. She represents the ABI on the MBS Advisory Committee. Dr. Maureen Dolan Assistant research professor. She co-mentors an MBS student and is an at-large member of the MBS Program Committee Dr. Argelia Lorence (Secondary appointment in the Department of Chemistry and Physics; College of Science and Mathematics). She teaches a core course, (MBS 6243 Molecular Genetics and Genomics), has participated in the team taught Topics in Molecular BioSciences (MBS 7123) and has built an extensive research program (total funding >$1,500,000) and mentors 3 MBS students. Dr. Lorence represents the Department of Chemistry and Physics on the MBS Program Committee. Dr. Brett Savary (Secondary appointment in the College of Agriculture and Technology) He has taught MBS 6251 Techniques in Molecular Biosciences. Dr. Savary has an active research lab with >$400.000 in funding Dr Jianfeng (Jay) Xu (Secondary appointment in the College of Agriculture and Technology). Dr. Xu joined the ABI faculty in 2008 and mentors 1 MBS student. Dr Shiguang Yu, will be joining the ABI faculty (immunologist) in March, 2009. He has already begun recruiting an MBS student.

College of Agriculture and Technology Faculty Dr. Soohyoun Ahn is the coordinator of the team taught course Advanced Cell Biology (MBS 6213) Dr. Elizabeth Hood holds an appointment as the Lipscomb Distinguished Professor of Agriculture (2008-present). She is also the Director of the Center for BioFuels and BioBased products. She has built a well-funded research program (total funding >$2,000,000) and mentors 2 MBS students. Dr. Hood represents the College of Agriculture and Technology on the MBS Program Committee.

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Dr. Greg Phillips (Dean College of Agriculture and Technology). Dr Phillips mentors 1 MBS student, serves on the MBS Advisory committee, and has maintained an active laboratory (>$500,000 in funding).

College of Science and Mathematics Faculty Department of Biological Sciences

Dr. Anne Grippo Associate Director of MBS and a member of the MBS program committee. She supervises Seminar in Molecular Biosciences (MBS 7111). Dr. Ron Johnson Associate Chair, Department of Biological Sciences. Dr. Johnson represents the Department of Biological Sciences on the MBS Program Committee Dr. Malathi Srivatsan Dr. Srivatsan has built a well-funded research program (>$1,400,000 in funding) and mentors 3 MBS students.

Department of Computer Science Dr. Xiuzhen Huang. Dr Huang mentors 1 MBS student (research funding >$600,000). She has taught the techniques course “Genomics and Bioinformatics” (MBS 6251)

Dr. Andy Sustich, Interim Dean College of Science and Mathematics and Dean of the Graduate School. Dr Sustich is a member of the MBS Advisory Committee and contributes to the evaluation of the Director’s performance.

Associated Faculty These faculty members have requested that they be associated with MBS. However, to date, they do not mentor an MBS student or teach a core course. Drs Tom Risch and Tanja McKay (Department of Biological Sciences), Amy Pearce and Kris Biondolillo, (Department of Psychology and Counseling), and Ellis Benjamin (Department of Chemistry and Physics).

Faculty Productivity In addition to information about student mentoring (presented elsewhere) informative measures of faculty participating in a research-based doctoral program include funding, peer-reviewed publications, book chapters and patent applications. Therefore these metrics are presented in Figures 1-3. A complete compilation of faculty funding and publications is found in Appendix D.

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Figure 1. Total Annual Funding of All MBS Faculty. This graph shows all (intra-and extramural on which a MBS faculty member served as Pi or Co-PI) in US dollars funding active in the designated year. We appreciate that this is not the most informative way to count faculty funding, but this method has been used by other academic units at ASU. Therefore, to allow comparisons with those data this accounting method is used. The reader is referred to Figure 2 for a more useful accounting. Data for 2009 are funds secured through 02/26/2009.

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Figure 2. Total Annual Extramural Funding of MBS “Core Faculty”. This graph shows only extra-mural funding (in US dollars of funding active in the designated year) which a MBS “Core Faculty” member served as PI. Intramural funds and grants on which MBS faculty members were Co-PIs are NOT included. Departmental designations refer to each faculty member’s primary appointment. This method of accounting is more accurate as it eliminates duplication and only “counts” funds for which ASU faculty are primarily responsible. Previous to 2008, the director’s grants were included in the total for the Department of Biological Sciences. Data for 2009 are funds secured through 02/26/2009 only so the amount received in 2009 should increase significantly by the end of the year. “Extramural grants” are defined as those that were competitively awarded and include federal and state sources.

Figure 3: Publications (peer-reviewed, book chapters and patent applications of MBS “core faculty”.

The data in Figures 1-3 show that productivity of MBS faculty isgrowing rapidly. Some of this growth can be attributed to an increase in the number of “core faculty” in MBS; however an inspection of the data shown in Appendix D will show that most of the increase is due to increased productivity of existing faculty members, not the aof new faculty. In many

ddition


respects, Figure 2 is the most informative as it describes the increase in extramural funding by MBS core faculty who serve as PIs on grants. This figure also shows the relative contributions of units where MBS faculty members have primary appointments. These data show that the most rapid growth in funding is occurring as a result of activity by MBS and College of Agriculture and Technology faculty and that faculty whose primary appointment is in the Department of Biological Sciences are major contributors. For these purpose extramural grants are Faculty Orientation and Evaluation: All new ASU faculty members must participate in a 2 day faculty orientation held at the beginning of each Fall semester. This is a comprehensive orientation to life as a faculty member at ASU. In addition, the ABI, Colleges and other academic units have orientation procedures for all their new faculty members. ASU also has a 1 day orientation for all new employees that must be attended by new faculty who are hired after the annual faculty orientation. These faculty members must also participate in the fall faculty orientation when it is next offered. The most recent ASU guidelines for faculty evaluation are contained in the 2008 Plan for Annual Faculty Performance Review. This document may be found in Appendix G. Student evaluations for elective courses are conducted by the departments offering the courses. In some cases these evaluations also include peer evaluations. Student evaluations of MBS core courses are conducted by the MBS program and reviewed by the director. Faculty performance evaluations are conducted by chairs or deans of academic units (for those holding primary appointments in an academic department) or the ASU ABI director (for those holding a primary appointment in the ASU ABI).

INTELLECTUAL PROPERTY The MBS has an entrepreneurial mission. The nature of the research of MBS faculty lends itself to invention and product applications. Several MBS faculty hold patents or have recently filed patent of provisional patent applications. MBS faculty inventors are encouraged to file SBIR/STTR applications. At present, MBS faculty members are involved with high-tech start-up companies that have 2 SBIR phase 1 proposals and 1 SBIR Phase 2 proposal funded. Inventions from faculty and students are governed by the Intellectual Property policy of the university (See Appendix G). Briefly, faculty, staff and student inventors are required to file disclosures of inventions to ASU’s ORTT, and the university will determine whether a patent will be filed. If not, the invention is returned to the inventor, and the inventor is free to pursue patent filing. If ASU files a patent application, ASU owns the IP and is responsible for patenting the invention. An example of entrepreneurial activities at ASU is that in-house start-up companies are licensing their inventions and applying for and receiving SBIR support to move those inventions into products. This is a relatively new activity for ASU—technology companies developed from the life sciences-based research. In support of this mission and ASU strategic priorities, MBS and the College of Business (Dr. Bill Roe, Associate Dean, Graduate Director) are partnering to provide student training in intellectual property (IP) and entrepreneurship. Entrepreneurial courses are being developed as a joint venture between the MBS program and the College of Business. Two courses are being proposed to the curriculum committees. The first will be an MBS course (Fundamentals of Entrepreneurship for Scientists) and will cover the process of IP development from initial discovery through patenting. This course will be

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taught by MBS faculty with assistance from the ORTT and the College of Business. We hope to be able to offer this course during the fall 2009 semester. The second course deals with start-up company activities that turn IP into products. This course will be housed in the College of Business and will be targeted to graduate and undergraduate students from all disciplines. It will be taught primarily by College of Business faculty with assistance from ORTT and MBS. We hope to offer this course in the spring 2010 semester. These courses are yet another example of the multi/cross-disciplinary foundation of MBS and require the cooperation of multiple departments, colleges and programs. This type of activity is enabled and facilitated by adopting an administrative structure that provides maximum flexibility and positions MBS to be able to reach across traditional academic boundaries to provide courses and training for ASU students.

PROGRAM RESOURCES Considering the broadly interdisciplinary nature of the program and our ability to draw upon a wide range of colleges and departments, the classrooms and other instructional resources are adequate to meet the immediate needs of the program. In addition to the Faculty affiliated with MBS, several other research staff members are involved in research and training MBS students. These include Research Assistant Professors, Postdoctoral Research Associates, laboratory technicians and as well as adjunct Faculty from other institutions who serve on dissertation committees and who collaborate with MBS faculty and students. Research Assistant Professors pursue their own research agendas and share laboratory space with MBS faculty and students. In many case these non-tenure track Faculty work in tight collaboration with a tenured-faculty. In keeping with MBS goals and ASU priorities, MBS faculty members are expanding collaborations with researchers from other state, national and international institutions. At present there are 10 adjunct Faculty from other institutions who serve on MBS student dissertation committees. The office of the MBS Director, many MBS students and MBS faculty research labs are housed in the Arkansas State University Biosciences Institute (ABI) building. This is a 94,000 ft2 state-of-the-art research building that opened on September 18, 2004, is dedicated to basic and applied research at the interface of agriculture and medicine. Space and resources within this facility are not limited to ABI faculty or those associated with MBS, but are available to any ASU researcher whose interests are compatible with the ABI mission. The ABI has invested over $4,000,000 in equipment used for research and teaching and the ABI building houses an extensive, modern suite of equipment that supports research in a number of different disciplines13. Thus, this building is an important resource for researchers from science-based graduate and undergraduate programs and has proven to be an important asset in the recruitment of faculty and students for a number of academic units. The ABI mission,14 the role it plays in ASU’s mission and in MBS and even the architecture of the ABI building are designed to foster the development of multi/cross- 13 A complete list of inventoried equipment purchased with ABI funds is in Appendix E. 14 The ABI at ASU has been directed by the state ABI Board of Directors to focus on plant-made pharmaceuticals (pharmaceutical compounds such as vaccines, produced cost-effectively in crop plants) and nutriceuticals (health-promoting foods and food components). This mission complements that of the ABI at the University of Arkansas: Division of Agriculture (U of A Ag), which is charged with developing improved crop varieties and crop production practices aimed at the biopharmaceutical and health food


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disciplinary research clusters. To date active clusters comprised of faculty and students from many different departments, disciplines and subdisciplines include groups focused on:

• Plant-based protein bioproduction, • Plant metabolic engineering for enhanced nutrition and medically active

compounds, • Treatment of human diseases using naturally occurring plant products and

engineered plant-derived compounds • Addiction especially as linked to development of potential plant and plant-derived

compound-based treatments, • Application of modern analytics to questions of plant and animal cell biology,

metabolomics, and biochemistry • Molecular technologies for food science, • Immune modulation and assessment especially as impacted by plant-based

products. The research laboratories are serviced by shared equipment rooms (with Sorvall RC5C and Revolution centrifuges, a Beckman Ultracentrifuge, -80 and -20 freezers, ice machines, etc.), 2 dark rooms with automated film-processors, RO and ultra-pure water purification systems, a containment laboratory for radio-isotope use, a central dishwashing/ autoclave facility, and several specialize support facilities (described below). Additionally, the building contains conference and seminar rooms, journal reading areas, break rooms, and office/desk areas to foster a highly interactive research environment. The building is fully “wired” with potential for more than 400 data ports. Wireless internet access is available throughout the building. MBS students and faculty are able to use several ABI Specialized Support Facilities that facilitate research from plant-or microbe based production, purification, analytical characterization to analysis of bioactivity in animal cells, tissues or small animal. These research facilities are available to faculty and students from all departments on campus so that MBS faculty and students who are housed in other buildings have free access to them. Plant Transformation and Propagation Facilities include two equipped clean rooms for biolistic and Agrobacterium-mediated plant transformation and cell culture and dedicated rooms for lighted growth chambers and for shakers and hairy root biofermentors. For larger scale propagation, ABI has a 1,100 ft2 plant growth room with two walk-in growth chambers, 10 fully-computerized 3x8’ Conviron environmental chambers, and space/plumbing for an additional 4 walk-in chambers to be added as needed. A roof top greenhouse provides almost 4,000 ft2 of computer-control glasshouse space with an adjacent 1,680 ft2 head-house area including a large walk-in cold room and pesticide/soil storage areas. Animal Cell Culture Facilities include two clean rooms with laminar flow hoods, CO2 incubators, roller-bottle systems, centrifuges and microscopes and adjacent support markets, and ASU and the U of A Ag are developing collaborative projects to support this ABI mission. Pharmaceutical and biomedical expertise at UAMS and the Arkansas Children's Hospital are needed to interface with plant biotechnology at ASU to accomplish the ABI mission. ASU currently has collaborative research projects ongoing with all 4 of the partner institutions.


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room for storage of media, dedicated refrigerators, and liquid N2 storage of cells. An additional clean room is housed within the animal care facility to facilitate establishment of primary cultures. The Small Animal Facility is a 3,800 ft2 complex that includes a gowning area, surgery and surgery prep room including anesthesia machines, large automatic cage-washing systems, five animal housing rooms (quarantine room, 2 rat rooms, 2 mice rooms), and two procedures rooms (one outfitted for primary cell culture). Initial outfitting provides individually vented high-density caging systems with a capacity of more than 800 mice and 800 rats in addition to the quarantine area (NIH Animal Welfare Assurance #A4506-01). Microscopy Facilities within the ABI building house a Nikon Eclipse E800 laser confocal scope and camera system, a Zeiss Axiovert 200M inverted fluorescence scope fitted with a BioVision CARV confocal system and SensiCam SVGA high-speed cooled digital camera, and a Zeiss Axiovert 40C for brightfield, fluorescence, DIC and phase contrast. The Shared Analytical Laboratory supports separation, detection and measurement ranging from small molecules to macromolecules and includes a Varian Saturn GC-MS (Q-it), 2 Perkin Elmer Clarus 500 GC-MS, a PerkinElmer 9000 ICP-MS, a Dionex 1000 HPLC (with PDA detector, ECD and fluorescence detectors), Cetac LSX 500 266nm and LSX213 Laser Ablation systems, a Thermo Fluorometer, FTIR, an autotitrator and a clean room with laminar flow hood for sample and standard preparation, and 2 miniature time of flight spectrometers. This facility also houses equipment for homogenization, microwave assisted digestion, extraction and derivatization of plant and animal tissues. A Waters MALDI-Micro TOF MS is housed in Dr. Savary’s lab. Additional HPLCs and FPLCs are housed within investor-dedicated laboratories. Shared Molecular Biology Research Laboratory will support molecular biology research for faculty and students who may not have access to their own instruments and is currently being developed. MBS faculty and have secured grant funding to purchase a Bio-Rad CFX 96 RT-PCR, power supplies and electrophoresis equipment, a spectrophotometer, mixers, etc. The College of Agriculture has generously contributed a portion of its share of the student infrastructure fees to purchase additional support equipment. Although individual researchers have needed equipment, no other laboratory equipped for molecular biology that can be shared by research faculty and their students exists on the ASU campus. This facility may also be used to support teaching of MBS and department graduate courses. 15 A Shared Bioinformatics computer laboratory (purchased with funds supplied by the AR INBRE, the ABI, the department of Computer Science and MBS) houses computers, printers, software and ancillary equipment needed to perform and instruct students to perform database searches (BLAST, TAIR, etc.), sequence analysis (Sequencher, WorkBench) modeling, primer design, structural analysis, etc.

15 A complete list of inventoried equipment housed in the ABI building is in Appendix E. This is not a complete list of available equipment—some equipment is inventoried in various academic units, but probably captures ~90% of the available equipment purchased through 11/2008.


Other major equipment: A TESCAN Vega TS 5136 XM Scanning Electron Microscope (SEM) with Oxford Instruments INCA x-sight X-ray Microanalysis Detector and a Veeco/Digital Instruments Multimode Scanning Probe Microscope purchased by ABI and are housed in the EM facility in the nearby Biology Department. Additional analytical equipment is housed in the Department of Chemistry and Physics. Access Grid classroom (purchased with funds supplied by the NIH though the AR INBRE, supported by the library and IT Services) is in the library and is available to all University faculty and students needing access to distance learning, participation in symposia and remote conferencing. This infrastructure has been successfully used to develop multi-institutional research grant proposals. Cyber-Infrastructure Supported by IT Services, ASU provides excellent cyber infrastructure. Wireless access is available in nearly all parts of the campus, there are substantial student computer laboratories and the University has software agreements with several software suppliers so that students have free access to a variety of critical software (e.g. MS Office, MS operating systems, Symantec Anti-virus packages). ITS also provides purchasing and service support for faculty, staff and student computers. ASU is connected by Internet 2 to the World Wide Web. ITS also maintains necessary firewalls, email service (local and remote) and the ASU web presence. Library Resources: The MBS program does not presently have a library budget allocation (although Dr. Greg Philips, Dean College of Agriculture and Technology has requested one for the next academic year). However, most of the units in which MBS faculty hold primary or secondary appointments do have library budgets. Each of those units receives an allocation per year which can be used to purchase books, media, databases and online-journal subscriptions. In addition each MBS student can also order up to 3 books (expenditure limited to less $100 per book) per enrolled semester. The library provides access to a limited number of relevant journals. Therefore the most pressing need is to increase online-subscriptions to electronic journals in disciplines relevant to MBS. As a substitute, many of the research journals not available at the library can be accessed through the interlibrary loan system. This method of information access has significantly improved in the last 2 years so that many requested articles are now received via e-mail as .pdf files within 24-72 hours after ordering. The ABI at ASU is part of the state-wide Arkansas Biosciences Institute consortium funded by Arkansas’ tobacco settlement funds with a mandate to facilitate agriculture and biomedical research with a long-term goal of enhancing the health of Arkansans. Through this consortium, ASU researchers can access specialized facilities at member institution including the Advanced NMR and Protein Structure/Function Center at UA, Fayetteville and the Genomics Facilities at UAMS in Little Rock.

PROGRAM ASSESSMENT The assessment philosophy directing MBS assessment is one of using measures of output to judge success thus allowing participants the maximum flexibility in terms of the process or inputs that are used to achieve agreed upon goals. Even given the emphasis on outputs as the primary measure of success, discussions on inputs and processes in the context of MBS will often be presented so as to communicate and to provide information about shared views on the way to achieve success. The primary purpose of this assessment is to provide information to the Deans of the Colleges

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supporting MBS, the Advisory Committee, the Program Director, Program Committee, faculty, and students so that the success of the multi/cross-disciplinary MBS program can be adequately and objectively evaluated. Reports of student and faculty productivity will be prepared annually by the Director and Program Committee. These reports will be circulated to the members of the Advisory Committee, chairs of departments contributing to the program, the Associate Vice Chancellor for Research and Technology Transfer, and the Vice Chancellor of Academic Affairs and Research. Placement: The primary measure of success of a Ph.D. program is the quality of positions into which the PhD graduates are placed. The goal of our program is to consistently place our students at the higher ranked Universities or in positions of leadership in industry or government. Following the example of EVS, our record keeping will formally ask for feedback when students leave and as students move through their careers, so that we can better assess how we prepare students for their research careers. Each student will be interviewed by their committee when they complete their degree to obtain the student's evaluation of the Ph.D. program. The program secretary will maintain a list of contact information for our graduates and they will be contacted and asked for updated information on current positions and future prospects. Additionally students will be asked to provide us with brief comments regarding their view of the quality of their training as they gain some distance from their ASU experience. This will be done at one, three, five, and ten years after graduation. Director’s Performance: The Director’s performance is assessed annually by the Dean of the College of Agriculture and Technology in concert with the Dean of the College of Science and Mathematics (assisted by the chair of the Department of Biological Sciences), and the Director of the ABI. As is standard ASU practice for evaluating directors, deans and chairs, faculty active in MBS will also be surveyed for their opinions of the Director’s performance. This “360o” evaluation of the Director’s performance provides a mechanism by which all MBS stakeholders have input into the evaluation process. This process is coordinated by the Dean of the College of Agriculture and Technology. Student Performance: In a research-based program offering a terminal degree, research outcomes (peer-reviewed papers and presentations) are a primary means of assessing student performance. Receipt of scholarships, fellowships and other awards from professional societies are also important indicators of quality student performance. Every student in the MBS program is required to present at least 3 public defenses of their research. In addition they are expected to make regular presentations at appropriate scientific meetings and to have published at least one peer-reviewed manuscript before graduation. If students are not meeting these milestones, the Dissertation Committee must provide the MBS Program Committee with an explanation of why this requirement has not been met (e.g. student’s research was proprietary and cannot be published until appropriate disclosures and patent applications have been filed, the funding agency supporting the research would not allow publication of research results, etc). The program committee must approve the rationale before the degree can be granted. The MBS Program Committee discourages agreements that interfere with publication of research results and expects to be informed of the existence of such agreements before the student begins the research.

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Outcomes of current assessment efforts: This program is still in its infancy so assessment efforts have focused on student recruitment, student retention, student progress through their program, curriculum, and interactions with the contributing departments and colleges. These efforts have led to several important initiatives that have just been completed or are currently underway. Some of these include:

1) Establishment of the MBS Program Committee to provide direction and oversight for the program. The MBS Program Committee is critical to program and student assessment. For example, one of the most important functions of this committee is provide an avenue for students and faculty from any academic unit to have direct input into program direction and strategic planning. The program committee is developing more formal mechanisms for assessing faculty and student opinion, including regular surveys of Deans, directors, department chairs, faculty of supporting academic and research units and MBS students.

2) Development and introduction of the entrepreneurial courses described above. 3) Assessment, review and revision of student handbook and guidelines 4) Assessment review and revision of the administrative structures to ensure that

program personnel remain responsive to the needs of academic and research units who support this program and aligned with the ASU mission and strategic plans

5) Development of a shared molecular biology laboratory to support course work and student and faculty research. A combination of extramural, College of Agriculture and ABI funds are being used to outfit this shared facility.

6) Initiatives to enhance faculty grantsmanship 7) Designing and implementing a Teaching Assistantship program for MBS

students. This will provide a mechanism by which departments that need, but do not have sufficient expertise in molecular and cellular techniques to more effectively access the rich pool of expertise developed by MBS.

8) MBS faculty members have been surveyed to gauge their impressions about the multi-cross-disciplinary focus of this program, to all them direct feedback into the present review process and to assess their feelings about the administrative structures governing the MBS program. The results of that survey are described briefly below. The survey instrument and a compilation of faculty responses is in Appendix F

9) Begin tracking undergraduate and high school student participation. Research: A measure of success of the program will be the involvement of PhD students in producing high quality publication records during or shortly after the students' time in the program. An additional measure of success will be the number of students who are supported by self-generated funding through fellowships and scholarships (e.g. National Science Foundation Graduate Fellowships, Southern Regional Educational Board Doctoral Scholars Graduate Program etc.). Student Teaching: The development of teaching skills is an element of a quality Ph.D. program, so MBS students are expected to teach. Student teaching will be evaluated in the semester that they are teaching and evaluation results will be made available to the student, chair of the unit in which the student taught, dissertation committee members,

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the director and MBS program committee members. Additional program level evaluation will be made as described below. Assessment of student progress and learning outcomes: Based on the goals of the PhD program each student is evaluated each academic year by the student’s mentor, Dissertation Committee and the MBS Program Committee. This assessment allows the program to monitor the progress of each student and to ensure that the student is on-time for completion of the degree and that all academic stages are met in a timely manner. Nearly all MBS students are provided with financial support on a competitive basis through Teaching and/or Research Assistantships. Laboratory instructional performance by Teaching Assistants is assessed through student evaluations administered by the department providing the course. Students are counseled by a Program Director and their mentor in the area(s) in which they need improvement. Assessment at the Time of Admission: Admission into MBS is competitive and evaluated at several levels, including the ASU Graduate School, the MBS Program Committee, and faculty members in the applicant's area of interest. Applicants are evaluated based on undergraduate and/or graduate performance, academic background, score at least 1000 on the GRE (combined verbal and analytical), meet or exceed minimum TOEFL scores (if required), written communication skills and overall enthusiasm for the program. Ultimately, a faculty mentor agrees to accept and supervise the student's dissertation research program before a student will be admitted into the program. In some cases, students who are deemed deficient in one area may be admitted on a provisional basis, with clear directives for overcoming provisional status. Assessment of Student Dissertation Research: In consultation with the faculty supervisor, the student prepares and defends a dissertation research proposal, which is evaluated and approved by the student's committee. This research proposal is normally presented and defended by the student, usually in their second year in the program. The student's progress toward completion of the dissertation research is reviewed periodically by the student's committee. The student must prepare a written dissertation describing the original research, its findings and scientific significance. These results are presented and defended by the student in a public forum, and the student's committee votes on approval. A written dissertation that represents an original scientific contribution and that conforms to accepted University format is reviewed and approved by the student's committee. As a measure of the scientific quality of the dissertation research, it is expected that MBS students will have at least one paper published or in-press in the peer-reviewed primary literature from their dissertation research at the time of graduation.

RECOMMENDATIONS 1. Enhanced support for contributing units. Instruction of most of the program-specific courses is supplied by ABI faculty. Other core courses are taught by faculty with appointments in the College of Agriculture and Technology, while elective courses are regular offerings of participating departments. MBS student enrollment in elective courses contributes to the student credit hour production of the contributing departments. Thus, MBS is not dependent on teaching

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provided by academic units, while at the same time MBS enhances departmental productivity at little or (in most cases) no cost to the department. However, the situation with respect to the MBS Director is very different. Since the Director position is a 50% appointment, the academic unit supplying the Director loses 50% of the director’s services. In return for this loss, the unit receives $1,650 per semester to be used to hire replacement instructor(s) to teach the courses the Director no longer has time to teach. The Director would usually be a senior level faculty member; one who is capable of contributing teaching of upper level and graduate courses, thus, this compensation is clearly inadequate to hire a “replacement” instructor. Although there are clear advantages to the unit that may accrue from their relationship with the Director and from their participation in MBS, this seems to place an undue burden on the unit. This situation is not the result of any particular administrative structure and can only be resolved by increasing the funding available to the unit. Mentoring PhD-level students requires a significant investment of time, effort and money by unit faculty. In many cases this may require “reassignment” of faculty from teaching duties to insure that they have the time to effectively mentor students. This situation may become particularly acute if a faculty member takes responsibility for more than 1 student. As it is consistent with ASU strategic priorities to increase graduate student enrollment, mentoring graduate students is a practice that the University wishes to encourage. Also, according to state funding formulas, graduate student credit hours are funded at a higher level than undergraduate student credit hours, with PhD credits being funded at the highest level. As ASU seeks to move toward a designation as a “research intensive” institution, it seems prudent to make every possible effort to increase graduate student enrollments in existing graduate programs including MBS. Therefore we suggest that the University should return some of the money derived from increased graduate student enrollment to the units of the faculty member directing the student. This would allow units greater flexibility in hiring temporary faculty to teach courses and be another incentive for departments to encourage their faculty to participate in graduate programs in general and in MBS in particular. Increased compensation to academic units in return for their support of multi/cross-disciplinary graduate programs would also encourage the units to make strategic, targeted faculty hires that would position them for maximum benefit from MBS and other similar existing and yet to be developed programs. It is important to stress that this recommendation could encourage unit involvement without compromising the critical multi/cross-disciplinary nature of the graduate programs. 2. Enhanced support for MBS: The MBS budget is very small. This severely limits the ability of the program to support student recruitment, travel and faculty development. To date, MBS enrollment has been growing in spite of this challenge. This is primarily because grant funding available to support student stipends and research has grown rapidly, thereby allowing student recruitment by MBS faculty so that program growth has kept pace with (or exceeded) initial expectations. However, as the program continues to grow, at some point it will become necessary to invest additional funds in increasing program visibility, student recruitment and professional development efforts. The lack of library resources also has an impact on MBS. We are not alone in this concern; all research at ASU would be enhanced by increased access to electronic journal subscriptions. The library has been very responsive to needs of MBS faculty and

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students by providing quick and easy access via interlibrary loan. While this is significant assistance, it cannot fully replace the advantages resulting from electronic access. Expansion of these resources is expensive and will require allocating significant funds to the library, however as our research enterprise continues to grow, the need also increases. 3. Coordinated faculty recruitment: The growth of all of ASU’s multi/cross-disciplinary programs depends on targeted recruitment of new faculty. Certainly the productivity, development and progression toward tenure and promotion of all new faculty members are impacted by graduate student researchers. Thus, ASU needs to continue to stress that all new hires in the sciences should target positions that can complement and are easily assimilated by one or both of our multi/cross-disciplinary science programs. Additionally these programs provide an important resource and support group for new faculty thereby enhancing training and retention of new hires. The diversity of the MBS faculty is also a valuable asset as we seek to increase the diversity of ASU’s faculty. 4. Administrative structure: As part of this self-study considerable effort has been invested in exploring alternate administrative structures governing the MBS program. These explorations have been informed by consultation with Dr. Carole Cramer (Director of the ASU ABI), Dr. Ron Johnson (Associate Chair, Department of Biological Sciences), Dr. Greg Philips (Dean, College of Agriculture and Technology), Dr. John Pratte (Chair, Department of Chemistry and Physics), Dr. Al Romero (Chair, Department of Biological Sciences), Dr. Andrew Sustich (Interim Dean of the College of Science and Mathematics and Dean of the Graduate School), and the MBS program committee. Three options were been presented for administration of this program. In addition, faculty opinions about the suitability of these 3 options were assessed by surveying MBS faculty. The survey instrument and the results of the survey (including some very informative faculty comments) are described in more detail in Appendix F, but briefly the key findings are:

1) When asked about the importance of the multi/cross-disciplinary nature of the program 71% responded that it was “fundamental to them, their students and their research”, 33% responded that it was “nice, but didn’t really matter that much”, no one responded that they “didn’t care one way or the other”, or that it was a “problem”.

2) Faculty responses about their feelings about the current structure were: 47% were “enthusiastic” about it, 42% responded that they hadn’t known of the structure, “that it had had no effect on them, their students and their research” and 10% responded that it was “difficult for them, their students and their research”.

3) When asked about whether they would support moving the program to the Graduate School, 45% responded that they “preferred the present structure”, 40% responded that they would be “enthusiastic” about the move, 15% said they didn’t think it would make any “difference to them, their students or their research”, 5% responded that they preferred that MBS be moved to a department.

4) Responses to the possibility of moving MBS to a department showed that 90% of the respondents were concerned that moving MBS to a department would “dilute the multi-cross-disciplinary nature of the program and have a negative

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impact on them, their students and their research”, 5% responded that they thought that move would have no effect, 5% responded that they preferred moving MBS to the Department of Biological Sciences.

5) When asked about their general preferences about the administration of MBS 29% responded that they preferred the present administrative structure, 63% preferred moving to the graduate school, and 5% preferred moving to the Department of Biological Sciences. No one responded that they preferred moving MBS to the Department of Chemistry and Physics, or that they preferred to move MBS to another college or department.

Conclusions from survey results: Response to the survey was very good (21 of 22 responded). Faculty members clearly feel strongly about the importance of the multi/cross-disciplinary foundation of the program. They are satisfied with the current administrative structure governing MBS, but when presented with options, are about evenly split about the value of leaving MBS in its present position or moving it to the Graduate School. They are very concerned about the negative impact of moving MBS to a department; only 1 person supported that option. Director Evaluation and Oversight: The current administrative structures responsible for overseeing, informing, and evaluating MBS (described above) have been carefully crafted and are clearly defined to provide adequate oversight while simultaneously enhancing the multi/cross-disciplinary interactions that are foundational to the continued success of this program. The functionality of this system will only be enhanced as the search for the new Dean of the College of Science and Mathematics is completed and a new dean is hired. However, it may useful for the contribution of the MBS director to his academic unit to be more fully defined. This is easily accomplished by executing a document defining the contribution of the director to the teaching and service mission of the unit and by defining which aspects of the director’s performance the unit head is to evaluate. This strategy has been successfully implemented in the past to clarify the relationship between the Director of the Graduate Program in Environmental Sciences and the Chair of the Department of Biological Sciences. In that instance the Chair requested a clarification from the Dean responsible for oversight of the program. It was a simple, straightforward matter to formalize and clarify the arrangement between the dean, the chair and the director. Although this strategy is not currently in use, if a more formal understanding is deemed necessary it seems a simple matter for the unit head to request a clarification from the dean. Again, this strategy may be used to inform all particulars without compromising the critical multi/cross-disciplinary nature of MBS. Alternatively, because the director is likely be a senior level faculty member with significant research experience who is required to maintain a research program, any potential misunderstandings could be obviated if Director Appointments were full-time. However this will require additional resources. It this strategy was implemented, it may be possible to construct this position so that the director was required to derive a proportion of her/his salary from extramural funds. This would reduce the financial burden on the University while the director would be free to devote 100% of his time to the program and research and the academic unit from which the director came would be able to use at least a portion of the vacated salary line to hire a replacement instructor.

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Strengths and Weaknesses of Administrative Options 1) The existing structure

Strengths • Although it might be argued that placement of this program with major

oversight provided by the Dean of the College of Agriculture and Technology might interfere with the multi/cross-disciplinary mission of this program, to date, data do not support this conclusion.

• This placement allows maximal exposure of the program’s focus on plant molecular bioscience. This also enhances the ability of the ASU ABI to fulfill its state mandate. To date, this structure has preserved and enhanced the crucial multi/cross-disciplinary foundation of MBS.

• The “chain of command” is clearly defined, • The College of Agriculture and Technology has supplied resources (both

financial and human) to support the program. • Structures already exist that allow deans of other colleges and the Director of

the ABI to have direct input into the program. • The College of Agriculture and Technology has the necessary resources to

provide financial oversight for the program. Each of the dean’s has a full-time accountant responsible for college finances. The size of the Program budget is such that it would not be burdensome.

• The College of Agriculture and Technology has been the college most supportive of the entrepreneurial focus of MBS. This focus is becoming increasingly important to realizing ASU’s strategic plan and to institutional and program alignment state and regional priorities.

Weaknesses • At the time this structure was implemented there was a single Dean of the

Colleges of Agriculture and Technology and Science and Mathematics (the major contributing colleges). That situation has changed. The hiring of a new Dean of the College of Science and Mathematics may alter the dynamic between the colleges in such a way that MBS is seen as an “Agriculture” program. This may limit the ability of MBS to reach “across colleges” to maintain its multi/cross-disciplinary focus. How this situation develops will depend very much on cooperation between college deans to protect the multi/cross-disciplinary foundation of MBS and is difficult or to impossible to accurately predict.

2) Placing the MBS program into the Graduate school so that the Dean of the Graduate School provides direct supervision.

Strengths: • This is the option most preferred by MBS faculty. • As a long-term strategy, this move would best position MBS to maintain and

enhance its multi/cross-disciplinary mission. No college, department or faculty member could question the parochial nature of the program if it were placed in the Graduate School.

• This strategy has been used successfully on other campuses to build and maintain similar multi/cross-disciplinary programs.

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Weaknesses: At present there are some significant challenges to this move. However, all of these challenges can be met if the graduate school receives additional resources. Thus the wisdom of this move becomes one of logistics, not educational philosophy. • The Graduate School has no academic programs and therefore has no

experience administering them. At present this is an obstacle, however, it is not insurmountable. In fact, as ADHE concern about redundancy of graduate programs shows no sign of abating, ASU will continue to design, propose and develop multi/cross-disciplinary graduate programs. Enhancing the Graduate School resources may be strategically advisable and is could become home to a number of Graduate programs. Therefore, giving the Graduate school the resources necessary to administer this program might be a very good place to begin that process.

• The Graduate School has insufficient resources for financial administration of graduate programs. Unlike colleges, the graduate school does not have a full time accountant who can fulfill this need.

• The Graduate School does not have access to several important sources of funds derived from fees charged of all students—including those in the MBS program. For example, at present the program benefits from receiving a portion of the student Infrastructure fees, IT fees and library fees through the College of Agriculture and Technology. Since the Graduate School is not included in these distributions, access to these fees would be restricted. Obviously, this challenge could be met by altering the distribution system so that the graduate school was included in distribution of these fees.

3) Move MBS into an existing academic department. There is widespread agreement that this is the least desirable option, the MBS faculty are almost universally opposed to this move. A major concern is that moving MBS to a department would significantly decrease the ability of MBS to “reach across” academic units to offer truly multi/cross-disciplinary learning and research experiences for students and participating faculty. Moreover, one of the most important concerns raised by the suggestion to move MBS to a department is that because of the reluctance of ADHE to approve “redundant” graduate programs, ASU has worked diligently to identify and establish graduate programs that are unlike those offered by other institutions in the state. A key part of this strategy has been to propose programs that are truly multi/cross-disciplinary and that do not sit within departments. By developing multi/cross-disciplinary graduate programs, ASU has been “allowed” to become a PhD granting institution. Included in the ASU strategic plan is a priority of strengthening graduate, PhD level education. Realizing this priority will require the growth of existing programs and the development of new programs. Strategically, having multi/cross-disciplinary programs approved, in part because they are NOT traditional departmental programs, and then converting those programs into departmental-based programs seems rather difficult. This is not a trivial concern. It is probably in the best interests of the University to avoid being perceived as using a “bait-and-switch” tactic with the ADHE.

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Strengths: While there are no apparent advantages associated with this arrangement, a few arguments have been raised in favor of this move. • It has been suggested that a department could provide additional resources to

support this program. However, departments have fewer disposable resources than colleges. Investment of new funds in a department home for MBS would do little to enhance the multi/cross-disciplinary foundation of the program, but would likely be seen as benefitting the recipient department and not all the stakeholders in the program. If additional resources are available it would seem far more prudent to invest them in the Graduate School and transfer MBS to that unit.

• It has been suggested that oversight of the program is inadequate. That somehow having the program director answer to a college dean is not as effective as having the program director answer to a department chair.

• It has been suggested that evaluating the director’s performance would be simplified by placing MBS within a department. In some sense this might be true, however placing the program into a department seems more likely to complicate effective evaluation of the director by making it more difficult for deans and chairs of other departments to provide feedback critical to evaluating the director’s performance and informing program direction. In any case, any effective evaluation system will require input from many constituencies and administrators. Although a strategy to facilitate evaluation by multiple stakeholders can be envisioned, adequate evaluation will neither be simplified nor enhanced by moving MBS to a department.

• It has been suggested that placement of MBS within a department would simplify the administrative structure. However, deans have a much broader set of responsibilities and view of the needs of students and faculty in their units than would a department chair. Thus, unless the goal is to reduce MBS to a departmental program, an adequate administrative structure must include input from various levels of stakeholders. This is more easily accomplished by having the program housed within a college (or the graduate school) than in a department. Thus, the structure might be simpler, but would hardly be adequate for input by all stakeholders. Any confusion about the responsibilities of the director to the department can easily be handled by developing shared arrangements specifying the duties of the director and the compensation provided to the department for the director’s involvement.

• It has been suggested that moving MBS to a department would enhance faculty recruitment. That is probably true for the department home. It is unlikely that other units would perceive that recruiting faculty whose goals were constituent with those of another department as being in accord with their own self interest.

Weaknesses: Moving MBS to a department would severely impact the multi/cross-disciplinary nature of this program. This is apparent to those most closely involved in the program—the faculty. By associating MBS with a traditional academic department, faculty and students from other disciplines would be less likely to consider MBS as an option. For example, it is difficult to see how a student interested in Chemistry, or faculty in Chemistry would feel comfortable participating in a Biology program.

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• No single department has the financial and equipment resources needed to adequately support this program. The investment in state-of-the-art equipment needed to adequately train students enrolled in this program is considerable. As new technologies develop, as equipment becomes outdated or worn out new equipment must be purchased. No department on campus has the resources needed to support this ongoing expense.

• No department has the personnel to support the emphasis on cell and molecular biology (especially plant molecular biology), biochemistry and bioengineering needed for this program.

• Departmental resources for administering funds are already overburdened. Adding another program to their portfolio only exacerbates this situation.

Conclusion: Strategically, the best place for this (and other multi/cross-disciplinary programs) appears to be within the Graduate School. However additional resources will have to be allocated to the Graduate School so that it can meet the increased workload. Leaving the program where it is does not seem to be a problem at present, but could also impact MBS multi/cross-disciplinary foundation if other colleges are not convinced of the advantages that accrue to them as they support MBS. Whichever of these options is chosen, there are some minor additions that can be made to more clearly define the director’s contribution to the department that has lost a portion of her/his effort. There is no advantage, and serious and significant disadvantages, to moving MBS to a department.

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Appendices

Appendix A: MBS Student handbook (Last updated in 2008, the handbook is currently under assessment, review and revision by the MBS Program Committee.) Appendix B: Curriculum Vitae of “Core faculty” Appendix C: Course Syllabi

ASU policies for Introduction of New Courses Appendix D: Faculty Productivity Appendix E: Equipment Inventory Appendix F: Results of the MBS Faculty Survey Appendix G: Miscellaneous Documents: ASU Strategic Plan ASU Intellectual Property Policy MBS Brochure ASU Faculty Performance Evaluation Guidelines

Appendix A

MBS Student handbook

1

STUDENT HANDBOOK

MOLECULAR BIOSCIENCES

Ph.D. PROGRAM

Revision 8-20-07

2

Table of Contents

I. Program Overview and Student Progression A. Program Overview B. Degree Progression

1. General Advisor and Research Advisor 2. Assembling a PhD Advisory Committee 3. Research Proposal 4. Qualifying and Oral Proposal Examination 5. Final Oral Examination for the Ph.D.

C. Academic Performance

II. Getting Started and Knowing the Rules A. Registration and Tuition B. Student Conduct C. E-Mail Accounts D. Fee Statement E. Outside Employment F. Space G. Keys H. Mail Boxes I. Forms J. Supporting and Teaching K. Plagiarism

III. Working Conditions and Responsibilities A. Preamble B. Information About Policies and Procedures C. Communication About Academic Status D. Research Contributions E. University Governance F. Respectful Working Conditions G. Conditions of Employment H. Safe Working Environment I. Grievances

IV. Graduate Assistantships A. Teaching Assignments B. Term of Service C. Grievances D. Teaching Appointments E. Teaching Assistant Development F. Summer Support G. Research Assistantships H. Fellows I. Graduate Assistant Health Care Plan J. Benefits

V. Guidelines for Good Practice in the Graduate Student-Faculty Advisor Relationship A. Faculty Advisor’s Role B. Graduate Student’s Role C. The MBS Program’s Role

VI. Scientific Integrity

A. Academic Authorship B. Retention of Access to Research Data C. Relationship Between Students and Outside Entities D. Scientific Misconduct E. MBS Graduate Student Publication/Presentation Policy

SECTION I. PROGRAM OVERVIEW AND STUDENT PROGRESSION

A. PROGRAM OVERVIEW The cross-disciplinary Molecular Biosciences field is revolutionizing discovery and technological advances in disciplines ranging from agriculture to medicine, from forensics to environmental sciences, from food sciences to renewable energy. The Molecular Biosciences Graduate Program provides training and research opportunities that integrate molecular, genomic, cellular, and developmental information. The program has a strong emphasis on interdisciplinary approaches, state-of-the-art technologies and innovation to address real world problems. Most PhD Advisory Committees recommend that each student take all the core courses (see mbs.astate.edu). The remainder of the student’s course of study is determined by the PhD Advisory Committee and may be altered at any time at their discretion.

B. DEGREE PROGRESSION There are a series of projects and examinations that are meant to prepare and test the student’s potential for success in the program. Talk to your advisor to ensure that you know the steps and the importance of each. In general there is a Research proposal to be prepared and defined. This is part of the Qualifying Examination. This is followed by course work, extensive research, and ultimately, defense of a dissertation. The table below outlines the steps which are defined in more detail in the following paragraphs. (See MBS website http://mbs.astate.edu/ for forms)

TIMELINE EVENT NOTES Before first semester Assigned General Advisor (if

necessary) Most MBS students will have entered the program having already chosen a Research advisor.

By end of 2nd semester Choose a Research Advisor and assemble PhD Advisory Committee

Submit PhD Advisory Committee Composition form

By end of 1st year • Program of study outlined by PhD Advisory Committee

• Set date for Qualifying Exam

• Submit Program of Study form to MBS office

• Submit Intent to Take Qualifying Exam form to MBS office

During 3rd semester Research proposal to Committee; Qualifying Exam public defense

Focused on student’s intended research; submit Pass Qualifier form to MBS office

Within 1 year of passing Qualifying Exam

Research proposal to Committee; Candidacy Exam public defense

Focused on research outside student’s dissertation research area; submit Pass Candidacy form to MBS office

In last semester Dissertation to Committee; public defense of dissertation

Submit Intent to Graduate form to Graduate School; Submit Intent to Defend form to MBS office; submit Pass Defense form to MBS office

1. General Advisor and Research Advisor General Advisor: Students who are not recruited to work with a specific advisor or who did not identify an advisor at the time of application will be assigned a “general advisor”. This faculty mentor will be a member of the Program Committee and will be cognizant of all program policies and regulations. The “general advisor” will be assigned to the student before his or her arrival and will meet with the student prior to the start of the first semester in residence to be advised on program policies, expectations, and to develop a basic program of study plan to be followed until the research advisor has been selected. Some of the responsibilities which can be assumed by the “general advisor” are: 1. Advising students on their course program and discussion of specialty area requirements. 2. Working with the student to identify a research advisor. 3. Serving as a point of contact for the student throughout their program of study. 4. Ensuring that the student is aware of program policies, procedures, and regulations. 5. Ensuring that the student gets a broad range of learning experiences.

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6. Reviewing student performance as a teaching assistant as well as in courses. 7. Recommendations to the Graduate Program Committee regarding a student’s progress. Research Advisor: A student must select a permanent research advisor by the end of the first semester. Failure to choose a permanent research advisor before the second week of the second (normally spring) semester will cause the student to no longer be in good academic standing and could result in no summer support from the program. The advisor will often, but not always, be a member of the specialty area nearest to the student’s research interests. The research advisor automatically becomes chair of the PhD Advisory Committee and assumes primary responsibility for advising the student on coursework and other academic matters. During graduate student orientation, a series of sessions may be held at which all faculty members who wish will give a brief overview of their research programs. All new graduate students are encouraged to attend these sessions, as they are particularly useful in helping to identify faculty who should be interviewed at length about their research. The selection of the research advisor should be made no later than the end of the first semester in residence and the Advisor should notify the Program Office when the selection has been made. Finally, program policy limits the total period of time for which any one student can hold a Graduate Assistantship from the Program Office (typically six semesters for PhD students). Therefore, it is important and entirely appropriate for you to inquire about and consider carefully the ability of a given potential faculty advisor to support new students entering the research group as Research Assistants. Feel free to ask faculty about details of how long the average student has spent earning the degree in that group in the past and how many semesters of support were provided via the program, a teaching assistantship from the host department or the graduate school vs. a research assistantship. Secondly, you should inquire about existing and pending research grants of the faculty member. Lastly you should become informed about fellowships and scholarships available from external sources for which you are eligible to apply.

2. Assembling a PhD Advisory Committee: No later than the end of the second semester in residence, prior to taking qualifying examinations, each students and his or her advisor should assemble a PhD Advisory Committee. PhD Advisory Committees are comprised of a minimum of five members of which one may be external to the institution. The PhD Advisory Committee’s responsibilities include, but are not limited to: 1. Advising students on their course program and discussion of specialty area requirements. 2. Determining the nature of the qualifying and oral proposal defense examinations. 3. Ensuring that each student gets an appropriate range of learning experiences. 4. Review of performance in teaching, courses, examinations, and research. 5. Recommendations to the Program Committee regarding a student’s progress. 6. Establishing the qualifying and oral proposal defense examination deadlines for students entering the

program and ensuring that students complete these milestones in a timely manner 7. Recommending to the Director of the Graduate Program in Molecular Biosciences the inclusion or

exclusion of previous graduate level coursework as part of the Program of Study. Changes in Committees: To petition for a change of an PhD Advisory Committee the student should submit the Petition to Change PhD Advisory Committee Form. This form must be submitted with the reason for the request and must include the signatures of the advisor, the faculty member who is to be added to the committee, and the member who is being replaced, if applicable. This form is available in the Program Office and on-line (mbs.astate.edu). The completed and signed form should be submitted to the Director of the Graduate Program in Molecular Biosciences. Be aware that it is virtually impossible (by Graduate School policy) to change the membership of the PhD Advisory Committee between an initially failed qualifying or candidacy examination and the retake (if permitted) of the exam. Students and faculty alike should consider this in their planning when faculty will be on leave in the semester/year subsequent to the first examination date. The Graduate School also requires that a minimum of ten weeks pass before retaking a qualifying or candidacy exam.

3. Research Proposal The purpose of the Qualifying Examination, consisting of the student’s research proposal and subsequent oral examination of the proposal, is to evaluate whether the student has begun to acquire the skills

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necessary to complete and defend a Ph.D. dissertation appropriate to the student’s degree plan. These skills are demonstrated by the preparation of a written document which describes the background and current status of the student’s research problem. In addition, the student must present and defend his or her research plans orally to a public forum. The Qualifying Examination must be scheduled by the third semester of the student’s program.

Within one year of successfully passing the Qualifying Examination, each student must prepare and defend a hypothesis-driven research proposal outside the area of his or her thesis project. The topic of the proposal must be approved by the student’s PhD Advisory Committee, and follow the format of an approved federal agency. Successful completion of this Candidacy Examination will qualify the student for candidacy to the Ph.D. in Molecular Biosciences. Therefore, for Ph.D. students there are two sets of examinations. These tests are administered by faculty and defended publicly. Passing these exams implies that the student has acquired sufficient knowledge in the research area, as well as in another area of Molecular Biosciences. The student will have shown the development of the critical thinking skills to be able to solve any problems that might arise during the research. It is the purpose of the faculty to assess whether the graduate student has the necessary knowledge and skills to successfully obtain a Ph.D. A Ph.D. degree is granted only after someone has demonstrated the ability to critically examine a problem and solve it. Implicit in the Ph.D. degree is the ability to form a research hypothesis based on previous knowledge in the area, design the critical experiments necessary to test the hypothesis, analyze the experimental data, propose additional experiments based on the given data, and come to a successful resolution of the problem. The outline for both proposals and oral exams should follow the above strategy. The format that has been chosen by most Molecular Biosciences faculty is that typical of a National Science Foundation proposal.

The first step in solving any problem is the ability to correctly identify the problem and state the steps necessary to solve the problem. The next step is to analyze the problem as it relates to previous research in the field. The third step is to state how any preliminary results that have been obtained relate to the potential success of the project. The final step is to use the preliminary results to design future experiments, and extrapolate from the future results how the problem will be solved. The critical points that the faculty expects to see in the proposals and the oral exams include: What are the key experiments necessary to answer the problem, and why are they the key experiments?

Because each project is unique, it is impossible to specify exactly what should be contained in a proposal. However, there are guidelines that are usually common to all proposals. These include: i. Brief abstract (0.5 - 1 page) ii. Specific aims (1 page) iii. Background and significance (3-4 pages) iv. Preliminary results (3-5 pages) v. Research design and methods (3-5 pages) vi. Cited Literature (pages as needed and not part of page limit) Experimental design, anticipated results, and how these results relate to the goals and objectives should be discussed. The entire document should have a maximum of 15 single spaced pages (font ≥ 11, inclusive of figures, and tables. Added pages for references are appropriate.

4. Qualifying and Candidacy Written and Oral Proposal Examinations At the time that the Program of Study Form is submitted (by the end of the first year), Ph.D. students should submit the Intent Form to take the Qualifying Examinations. The form should include the names of the faculty members who will administer the examination. It is the student’s responsibility to obtain the required signatures before submitting the form. Please note that you should ask permission of each faculty member whose name appears on any Form submitted to the Program Office. Doctoral students should submit an Intent to Defend the Research Proposal Form to the Program Office and Graduate School in a timely manner, which includes the date of the public proposal seminar. Oral Proposal Examination: The oral examination for Ph.D. candidacy in Molecular Biosciences will consist of the presentation of the student’s research proposal (not to exceed 30-35 minutes) with a follow-

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up period for questioning. This presentation is public and the examination may include questions from the general audience as well as the requisite closed door proposal examination. After the presentation and a short break, there will be an additional period of general questioning by the advisor committee on topics such as coursework, seminars, current literature or other matters of timely interest to Molecular Biosciences. Within one year of passing the Qualifying Examination, students should submit the Intent to Take the Candidacy Examination form. The format of this exam is very similar to the Qualifying Exam, except that the research proposal is expected to be written in the form of a grant proposal to an approved federal agency, and must describe a research project outside the field of the student’s proposed research. Again, a public oral defense must be undertaken. Passing this exam qualifies the student as a Candidate for the Ph.D. in Molecular Biosciences.

5. Final oral examination for the Ph.D. (The Defense) After an extensive research project, the student is required to present the written dissertation to his or her PhD Advisory Committee, and hold the final public defense. The Intent to Defend Form must be submitted to the MBS Program Office and Graduate School a minimum of three weeks before the defense date, in compliance with Graduate School requirements for graduation in that semester. All members of the PhD Advisory Committee must be in attendance unless an outside member is unable to attend, in which case the Program Office must be notified at least two weeks in advance of the member’s proxy. Questions provided by the absent member must be asked by the proxy, and answers recorded for review by the absent member. It is the student’s responsibility to contact all members of the PhD Advisory Committee regarding their willingness to give the final oral examination. All signatures should be obtained before the final acceptance of dissertation form is submitted to the Graduate School.

C. ACADEMIC PERFORMANCE What follows is a guide to the level of academic performance expected of graduate students. If a student is doubtful about his or her present academic status, the student should consult with the PhD Advisory Committee, research advisor, or with the Director of the MBS Graduate Program. In the following, whenever grade point average (GPA) is mentioned, it means the GPA in actual courses graded on a letter scale system, exclusive of research credits.

Academic performance: If a student’s record indicates any of the items listed below, the student’s performance may be considered unsatisfactory, is a cause for concern, and may jeopardize a student’s standing as a graduate student in the Molecular Biosciences Program. Review of the student’s progress: Each semester the MBS Director reviews the progress of graduate students and the MBS Program Committee reviews the first-year students. Other than in exceptional circumstances, a decision to reassign a student from the Ph.D. to a suitable M.S. degree program is not made until the end of the first year. Following the first year, academic review is done annually at the end of Spring semester. Reassignment from the Ph.D. to a suitable M.S Degree Program: At the following points in a student’s career, the Ph.D. student faces the possibility of being assigned to a suitable M.S. program if academic progress has not been satisfactory.

1. Any course grade below B. A grade of C will result in the student being placed on academic probation. A second C or a grade of D will results in the student’s dismissal from the Graduate Program in Molecular Biosciences and may result in dismissal from the Graduate School.

2. Failure to pass the qualifying examinations by the end of the fourth semester in residence. 3. A cumulative GPA below 3.00 (minus research credits). 4. Completion of fewer than 18 credits with a grade of B or better at the end of the first year in

residence. Insufficient progress toward a degree as manifested by too few course credits of B or better beyond the first year.

5. Students who have not demonstrated English proficiency by the end of their first year of residency as determined by the PhD Advisory Committee and MBS Program Committee will not be eligible for further program support (although Research Assistantships may still be arranged with individual faculty members).

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SECTION II. GETTING STARTED AND KNOWING THE RULES This section contains essential information for all graduate students in the Graduate Program in Molecular Biosciences (MBS). Most MBS graduate students hold Graduate Assistantships in the form of externally funded research assistantships (RA) or University supported Teaching Assistantships (TA). All graduate students are responsible for knowing and complying with information in this manual that relates to their academic and service responsibilities.

A. Registration and Tuition Graduate Assistants: If you are a graduate assistant, carefully review this section. If you have questions, contact the Arkansas State University Graduate School (972-3029) or the Graduate Program in Molecular Biosciences (972-2007). To hold an assistantship, you must be registered for 9 hours each fall or spring semester you hold an appointment. If you are supported during the summer sessions as a graduate assistant you must register for one credit hour per summer session in which you receive support. If you do not register in a semester, or if you drop below the full time minimum, your assistantship will automatically be terminated retroactive to the beginning of the semester, your job classification will change to a non-student title, you will be billed for any tuition benefit received that term, and social security taxes will be withheld from your wages. Nonresident students receive a full waiver of non-resident tuition and will receive the resident tuition waiver as outlined above. Contact the Arkansas State University Graduate School with questions about appointments, tuition benefits, or any billing problems associated with the above. Registration is a web-based procedure. Course offerings should be reviewed before the student’s first meeting with his or her PhD Advisory Committee, so that the first semester program may be filled in and approved at the PhD Advisory Committee meeting. Note that your registration will be delayed if the Graduate School has not received a final transcript from your previous college or university that shows you received your degree. The Graduate School requires students to register no later than the 11th day of classes. This date is the last day to register, add a course, change a section, or cancel a course without a “W” appearing on the transcript. Graduate students may cancel courses through the eighth week of the semester with the advisor’s signature. Courses canceled after the eighth week require the signatures of both the advisor and the course instructor. No registration changes are permitted after the last day of class of the semester. Active status is required for students to be able to register for courses, take exams, submit progress forms, file for graduation, or otherwise participate in the University community as a Graduate Student. All graduate assistants are eligible for resident tuition rates regardless of source of funding, MS or PhD status. NOTE: Faculty or graduate students applying for funding from an external agency for which request of tuition is allowed are required to include this request in their grant proposal. Please see Office of Research and Technology Transfer staff for assistance with all grant proposal submissions. B. Student Conduct You are responsible for abiding by the Student Conduct Code in the Student Handbook which can be accessed on-line at http://studentconduct.astate.edu/handbook2005-2006.html.

C. E-Mail Accounts Instructions to activate your account are at: http://its.astate.edu

D. Fee Statements All doctoral level graduate assistants receive a tuition waiver. Fulltime enrollment for a doctoral student is 9 hours per semester. Student account balances are provided to the student through the Banner system. Students are responsible for ensuring that their tuition and fees are paid in full as per University deadlines.

E. Outside Employment Graduate Assistants (TA, RA and Fellows) are strongly discouraged from accepting outside employment during the term of their appointment or award. This reflects the faculty’s conviction that prompt completion of graduate degree requirements should be the only demand on a graduate student’s time other than service as a graduate assistant. Should you decide to be a private tutor for pay, etc., consult with your advisor prior to doing so. Outside employment without the prior approval of the Primary Faculty Advisor and Director of the Graduate Program in Molecular Biosciences may jeopardize your position in the graduate program.

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http://studentconduct.astate.edu/handbook2005-2006.html

http://its.astate.edu/

F. Space Upon arrival, first-year Graduate Assistants may be assigned office and study space. When a research advisor is chosen (ideally done prior to admission to the program, but no later than the end of the first academic semester in residence), office and research space may be re-assigned by the Research Advisor. Please notify the Program Office if your office space has been re-assigned. Also notify the Program Office whenever you change office, office phone, local off-campus address, or off-campus phone. This notification is necessary to insure proper routing of communication and prompt updating of the program directory.

G. Keys Upon arrival, Graduate Assistants are issued keys to their assigned Program Office space. A deposit of $2.00 per key (in cash) is charged, refundable upon return of the keys and the deposit receipt to the Program Office. Office keys also open the outside doors of Laboratory Sciences West and East. Copying or altering of keys is not permitted. Loss of a key requires the payment of a $5.00 fine, as well as the cost of re-keying including all new locks and replacement keys. All GA’s sign a form signifying agreement of this policy when receiving keys (see back of Handbook). Additional keys, e.g., for research offices, may be obtained as needed with the proper authorization through the student’s host department.

H. Mail Boxes Students may be assigned a mailbox in their host department or may receive mail through the MBS program office. Please inform the office once you have chosen a mail drop location so that we can ensure that your mail arrives in a timely manner.

I. Forms From time to time it will be necessary to file various forms requiring the approval of the Director of the Graduate Program in Molecular Biosciences. All of this paperwork should be submitted directly to and picked up from the Program Office (rather than to and from the mailbox, secretary, office, or head of the host department).

J. Support and Teaching All Program support (TA and Program Fellow) is arranged by the Director of the Graduate Program in Molecular Biosciences and the Program Committee, and is based in part on information provided by the Graduate School and the student’s Research Advisor. Doctoral students typically receive a maximum of 6 semesters of Program funded support, however, additional support beyond 6 semesters is often provided by research grants. Summer support is also awarded based on availability of funds and student merit. Students and Research Advisors are encouraged to seek external funds to ensure continuity of student support throughout the length of graduate study.

K. Plagiarism Students who commit plagiarism are engaging in serious academic misconduct. They risk disciplinary action from the Program Office and the Graduate School, including the possibility of being removed from the graduate program. Students are often under the impression that plagiarism is simply the unattributed, verbatim quoting of published work. In fact, the definition is considerably broader. Rather, plagiarism is the act of presenting someone else’s ideas or data without acknowledgment. It is not sufficient simply to paraphrase. This is not to say that you must never paraphrase. You may, as long as you do so with appropriate attribution. Direct quotes of more than two or three words should include quotation marks. Whenever you draw on someone else’s ideas, you must attribute your source. The above guidelines apply to all work, whether it is published or not. If your research results, whether published or not, draw upon work described in a lab-mate’s thesis, you must reference it. If it contains an idea that you heard expressed at a scientific meeting, you should seek that person’s permission and then attribute it. The only exception is that you need not attribute facts that are so widespread as to be common knowledge. To give a trivial example, you need not attribute the periodic table should you cite the atomic mass of hydrogen. Graduate students enrolled in the Molecular Biosciences Program will be REQUIRED to complete a 1 credit hour course as part of their core in Responsible Conduct in Research which is offered each year. With this background and the above guidelines, you should now have a clear idea of what constitutes good professional conduct in scientific writing. Additional guidance is available from the University Office of Research and Technology Transfer as well as in other sections of this handbook. If you have any doubts about whether your writing is acceptable, you should consult your advisor, the

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professor of a course if the work is for class assignment, or the Director of the Graduate Program in Molecular Biosciences.

SECTION III. WORKING CONDITIONS AND RESPONSIBILITES A. Preamble A major purpose of graduate education at Arkansas State University is to instill in each student an understanding of and capacity for scholarship, independent judgment, academic rigor, and intellectual honesty. Graduate education is an opportunity for the student to develop into a professional scholar. Graduate research and teaching assistantships offer an “apprenticeship” experience in the academic profession as well as financial support. It is the joint responsibility of faculty and graduate students to work together to foster these ends through relationships that encourage freedom of inquiry, demonstrate personal and professional integrity, and foster mutual respect. This shared responsibility with faculty extends to all of the endeavors of graduate students, as students and members of the larger academic community. High quality graduate education depends on the professional and ethical conduct of the participants. Faculty and graduate students have complementary responsibilities in the maintenance of academic standards and the creation of high quality graduate programs. Excellence in graduate education is achieved when both faculty and students are highly motivated, possess the academic and professional backgrounds necessary to perform at the highest level, and are sincere in their desire to see each other succeed. The following principles illustrate what students should expect from the MBS Program and what the program expects from our students, to help achieve this excellence.

B. Information about Policies and Procedures The Graduate Program in Molecular Biosciences is responsible for providing access to information about graduate student financial support in the program, such as the prospects for fellowships, assistantships or other financial support and the proportion of students receiving financial support. All such information should be presented in a format that does not violate the privacy of individual students. The Program will make these materials available on our website or other readily accessible formats. Students are responsible for keeping themselves informed about current policies of the Program and the Graduate School that affect graduate students. Students and alumni also have a responsibility to respond to program inquiries about their career development.

C. Communication about Academic Status The Graduate Program in Molecular Biosciences is responsible for providing students with information about their individual academic status. Students are responsible for communicating with the Graduate School and the Program about changes in their circumstances that affect their status and progress toward the degree.

D. Research Contributions Individual faculty as research directors are responsible for providing students with appropriate recognition for their contributions at conferences, in professional publications, or in applications for patents. Students and faculty should be familiar with the University Intellectual Property Policy found on-line at http://researchoffice.astate.edu/policies.htm. It is the faculty member’s responsibility to clarify the principles for determining authorship and recognition at the beginning of any project. Students are responsible for discussing their expectations regarding acknowledgment of research contributions or intellectual property rights with the appropriate person(s) in the research team, preferably early in the project.

E. University Governance The Graduate Program in Molecular Biosciences and participating departments and Colleges are responsible for defining specific opportunities for student participation on committees as they deem appropriate. The University recognizes that graduate students make important contributions to governance and decision making at the program, department, college, Graduate School and University level; specific roles for participation are defined at each level by the relevant governing bodies. Students are eligible and encouraged to participate in University governance and decision making that enrich the campus community through service on committees etc.

F. Respectful Working Conditions

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http://researchoffice.astate.edu/policies.htm

University faculty and staff are responsible for assuring that graduate students are able to conduct their work in a manner consistent with professional conduct and integrity, free of intimidation or coercion. Students have the protection of University policies. The Program is responsible for providing clear communication to students about the possibility for appeal to a third party for assistance in resolving disputed issues. Students are responsible for reporting unprofessional conduct to the appropriate body or person, as defined in the University Grievance Policy; they should be able to do so without fear of reprisal. Students are responsible for acting in a respectful and fair manner toward other students, faculty, or staff in the conduct of their academic work or work they may do in connection with an assistantship.

G. Conditions of Employment The University (through its departments and Colleges, research projects or other employing units) is responsible for providing to prospective graduate assistants a written offer of financial support before a response to the offer is required. Such communication must indicate the stipend, and the terms and conditions of the appointment, including the general nature of the work they will be performing, duration of employment, and whether and how this employment is tied to their academic progress. The details of specific teaching or research assignments may need to await later written clarification. Students are responsible for accepting the conditions of appointment only if they believe they are qualified and able to complete the tasks assigned. Students have a responsibility for communicating in writing any changes in their circumstances that affect their ability to fulfill the terms and conditions of their appointment.

H. Safe Working Environment Supervisors are responsible for providing a safe working environment for graduate students, and for developing and publicizing safety policies and training programs to achieve that goal. Graduate students are responsible for helping to maintain a safe working environment, for adhering to safety policies, for participating in training programs and for reporting safety violations to the proper authority. University Documents providing further information and guidance relevant to the graduate education experience include the following:

Graduate Student Bulletin: http://www.collegesource.org/displayinfo/catalink.asp Student Handbook: http://studentconduct.astate.edu/handbook2005-2006.html Chemical Compliance Manual: http://ehc.astate.edu/indexbook.html Biological Safety Manual: http://ehc.astate.edu/ehc.html Intellectual Property Policy: http://researchoffice.astate.edu/policies.htm Faculty Handbook: http://academicaffairs.astate.edu/facultyhandbookdraft.htm I. Grievances If a conflict should arise between a graduate student and another member of the Graduate Program regarding a course, a teaching assignment, or a matter of research supervision, the student should make every effort to resolve this with the party or parties involved. If the problem remains unsolved at this level and it does not directly involve the Research Advisor, the student should consider the Research Advisor the first point of contact in resolving a grievance. If the issue is irresolvable by the student and Research Advisor or directly involves the Research Advisor, the student may request a meeting with the Program Director. In particular, grievances should be brought to the Director of the MBS Graduate Program, the chair of the host department, or Dean of the Graduate School as appropriate to the problem. Issues irresolvable at the Program or College level will be brought to the Dean of the Graduate School.

SECTION IV. GRADUATE ASSISTANTSHIPS A. Teaching Assistant Assignments Teaching Assistant (TA) assignments are made by the Director of the Graduate Program in Molecular Biosciences in collaboration with the student’s advisor and host department. If you have a strong preference for the type of teaching assignment you are given, it should be made known to the host department chair and your Research Advisor, and communicated to the Director. The initial teaching assignment occasionally conflicts with the graduate student’s course program. Since such cases are likely to involve laboratory sections in a multiple section course to which more than one Graduate Assistant is assigned, conflicts can usually be resolved by an exchange of sections among the assistants assigned to the same course. These exchanges should be handled by the person in charge of the TA

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http://www.collegesource.org/displayinfo/catalink.asp

http://studentconduct.astate.edu/handbook2005-2006.html

http://ehc.astate.edu/indexbook.html

http://ehc.astate.edu/ehc.html

http://researchoffice.astate.edu/policies.htm

http://academicaffairs.astate.edu/facultyhandbookdraft.htm

assignments for the particular course or for departmental TA assignments. Conflicts that cannot be resolved should be reported to the chair of the department in which the course is taught so that assignments can be rearranged. In case of foreseeable, unavoidable absences, the TA must notify the faculty member in charge of the course as early as possible, and arrange for a substitute. In case of illness or other emergencies, notify the host department office and/or the faculty member responsible for the course as early as possible so that a substitute can be found. When a substitute is arranged, it is assumed that the graduate student will repay the substitute by taking some of the substitute’s hours at a later date. Absences from assigned duties without an arrangement for having the duties covered by another TA are very serious infractions and may result in termination of the appointment. Any and all questions which arise concerning a TA’s teaching duties in a course should be referred to the faculty member in charge of that course. It is the TA’s responsibility to obtain information on the proper operation and grading of the course to which he or she is assigned. All TAs will have their teaching duties reviewed and rated each semester by the course instructor and/or the students. Consistently poor ratings or student complaints will be taken into consideration before reappointments are made.

B. Term of Service Appointments as a TA is typically offered on a semester basis, August 15-December 15, and January 1-May 15. Some summer teaching appointments may be available in connection with the limited offering of departmental courses in the summer. TAs should expect to devote a total of about 20 hours per week to a full graduate teaching assistantship or 10 hours per week to a half-time assignment. This time requirement will probably vary considerably from week to week. Full-time TAs generally teach no more than one lecture course or two to three laboratory sections per semester. Assignments which significantly differ from this estimate should be brought to the attention of the faculty in charge of the course or to the Director of the Graduate Program in Molecular Biosciences. Students who are transitioning from grant support and intend to request MBS support should contact the MBS office immediately to ensure consideration by the MBS Program Committee.

C. Grievances In the event that a TA has an issue with a student that they cannot solve on their own, or do not feel comfortable handling on their own, they should immediately contact their teaching supervisor and/or the instructor of record for the course, as well as their Research Advisor at the same time. If the problem cannot be solved at this level, the TA should contact, in collaboration with the Research Advisor, the host department chair. Only after the problem has been brought to the chair of the teaching host department and the issue remains unresolved should the TA bring the issue to the MBS Director. If the problem remains unresolved, the Director will take the issue to the College Dean and the Program Committee for further action. If the issue cannot be solved at the program or college level, the issue will be brought to the Dean of the Graduate School. Similarly, teaching supervisors who encounter issues with TAs should first consult the student, followed by the Research Advisor. If the problem remains unresolved, the supervisor should contact the teaching host department chair followed by the MBS Director. If the issue cannot be solved at the program or college level the issue will be brought to the Dean of the Graduate School.

D. Teaching Appointments Appointments of graduate assistants with classroom or laboratory teaching duties use the official title “Teaching Assistant”. No restrictions on the type of assignment should be inferred from the title. The graduate student may be assigned to grading, developing written solutions to problem sets, instructing laboratory or lecture sections, developing new laboratory or field activities, other educational duties, or a combination of any or all of these. TAs for whom English is a second language may be required to take a spoken English examination upon arrival to campus. Students who cannot demonstrate proficiency in this area may be re-assigned to other duties until such proficiency is demonstrated. Students who show no proficiency with spoken English after one year of residency in the program may be required to take English language courses (eg., Speech Communication) with additional costs being the responsibility of the student.

E. Teaching Assistant Development Resources provided in support of TA development include a collection of practical teaching tips housed in the Program office. Additional training is provided to new graduate students as part of the MANDATORY graduate student orientation program. Also host departments may provide additional training to students

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serving courses in these departments. TAs can request additional training through the Program Office, Graduate School, and host departments. There are also Teaching Suggestions in Appendix B.

F. Summer Support Support for the summer is independent of academic year support and may come from some combination of three different sources: Teaching Assistantships, Research Assistantships, and Program Fellowships. The sources of support for students will normally be communicated to them by their advisors. Summer support for Graduate Assistants is based on merit and availability of funds. Students who maintain timely progress towards completion of their degree may receive summer support from the Program as either a TA or fellow. Fellows do not have summer teaching responsibilities. Fellowships will be awarded to those students who have made exemplary progress and who have demonstrated outstanding scholarship. The award of Program summer support is based on recommendations from your Research Advisor and are awarded by the Graduate Program Committee. Students who receive summer support must register for 1-credit hour during the summer session in which support is awarded. Research Assistants will also be paid according to regular payroll dates, but appointments may begin and end at different times during the summer and stipend amounts may differ from the academic year. You should check with your Research Advisor to learn the schedule of payroll dates for individual situations.

G. Research Assistantships Appointments as Research Assistants (RA) are made from funds granted by government agencies, non-profit foundations, or industry with specific research projects proposed by members of the faculty. Such appointments are normally arranged between the Research Advisor and the student. The research performed under these appointments may be used to satisfy thesis and/or dissertation requirements. Research Assistantships are nearly always made at the 50% time level (i.e., 20 hours per week), and the stipend levels may be somewhat higher (~10%) than those provided by a combined 12 months of Teaching Assistantship/summer support. The continuity of a Research Assistantship is subject to the continued availability of funds. The Graduate Program in Molecular Biosciences will, however, work with students and Research Advisors to identify sources of alternative support in case of an unexpected termination/interruption of a research grant or program. To ensure reappointment in subsequent periods as an RA, it is expected that Research Assistants will remain on duty during periods of employment. Discharge of Research Assistants, with the exception of a lapse in funding, is the decision of the Research Advisor. However, criteria for selection, continuity, and discharge should be provided to both the Program and student at the start of the appointment. Terms of appointment must be commensurate with University and State regulations. If a Research Assistant is to be discharged, a letter from the Research Advisor must be entered into the student file. The letter of explanation must be signed by the student and the Research Advisor. It is recommended that Research Advisors who are providing grant support to students sign a formal contract indicating the responsibilities of the student and advisor, clarifying responsibilities of both parties and ensuring communication of expectations. Contact the Office of Research and Technology Transfer for assistance in crafting the appropriate document, and file a copy of this document with the MBS Program Office.

H. Graduate Assistant Health Care Plan International students are required to have hospitalization insurance. International students should contact the International Programs office regarding these arrangements (see the International Student section of this Handbook). At this time, University supported graduate students are not eligible for participation in the University Health Care Plan. Graduate Assistants are encouraged to purchase a private insurance plan. Research Assistants supported through external funds may be provided insurance coverage at the discretion of the funding agency and Research Advisor.

I. Benefits Graduate Assistants are covered by Workers’ Compensation but do not qualify for unemployment compensation. Graduate students injured in the laboratory or in the field should immediately notify the Office of Human Resources. Parental leave: A man or woman may take up to six weeks leave without pay related to the birth or adoption of his/her child. If Graduate Students wish to take leave they must make the proper arrangements with their Research Advisor, host department, MBS Program Office, and Graduate School to ensure continuity of Graduate Assistantship upon return. Emergency Leave: Should students encounter issues which preclude their ability to fulfill the obligations of their teaching, research assignment, or course work, students must inform the Graduate Program office that they wish to take

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Emergency Leave. Emergency Leave will effectively place the student on “hold” and will ensure that the semester(s) in which the student is on Emergency Leave do not count towards the number of enrolled semesters used towards timely completion of their degree. Students may receive an incomplete for courses or may withdraw and should discuss options with their instructors prior to taking Emergency Leave. The Program office will handle the paperwork associated with taking Emergency Leave. The student must leave current contact information with the office and periodically check in to inform of us the status of possible return or continuation of leave. Travel: Travel Accident Insurance is provided to Graduate Assistants on Arkansas State University business. A Travel Authorization form should be submitted to the MBS Program office in advance of travel to ensure coverage. Students should also be aware of the policies and procedures associated with field work (see the Travel Section of this Handbook for more information). Vacation: Although Graduate Assistants are afforded no “formal” vacation leave, this does not imply that they cannot take vacation time. Students should consult with their advisors regarding the time they wish to take for vacation.

SECTION V. GUIDELINES FOR GOOD PRACTICES IN THE GRADUATE STUDENT-FACULTY ADVISOR RELATIONSHIP

This discussion includes guidelines for:

Faculty Advisors Graduate Students Program and Host Departments High-quality graduate education depends upon the professional and ethical conduct of the participants. Although the University is composed of many distinct disciplinary “cultures,” its faculty and students together form a community of scholars. As such, they have complementary responsibilities for upholding academic standards and sustaining a creative and collegial environment. Focused on the professional academic relationship between faculty and graduate students, the following guidelines are based on the collective experience and wisdom of a number of major research universities. Their purpose is to encourage a heightened awareness of, and conscious commitment to, practices routinely followed by the great majority of faculty and students here and elsewhere as a matter of common sense, courtesy, and basic honesty. Although a few of these guidelines have more direct relevance to some fields than to others, most are applicable across the entire disciplinary spectrum.

A. Faculty Advisors should • serve as intellectual and professional mentors to their graduate students, by:

1. helping students develop laboratory, field, writing, oral, quantitative, or other relevant professional skills required by the discipline;

2. helping more advanced students design research programs that take advantage of their individual interests and strengths and that can be completed in a timely manner;

3. encouraging, by example and precept, a dedication to high-quality teaching; 4. encouraging faculty-graduate student collaborations which entail the sharing of authorship or

rights to intellectual property developed in research or other creative activity; 5. encouraging students to be open about any problems in their working relationships (including the

relationship with the advisor), and being open to making accommodations to deal with such problems;

6. providing students with evaluation of their progress and performance in regular and informative ways.

The Program recommends two meetings each semester at a minimum. It is especially important for faculty to provide students with timely and candid advice when their performance is deficient or their lack of progress might prevent them from attaining the desired degree.

• be knowledgeable concerning the academic and non-academic policies that pertain to graduate students, including: 1. helping students understand the requirements and timetable that each must meet, including

coursework, research tools, specific research responsibilities, examinations, and thesis or dissertation,

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2. discussing laboratory, departmental, Program, or University authorship policy with graduate students in advance of entering into collaborative projects;

3. drawing student’s attention to University policies on Intellectual Property, Environmental Health and Safety, Scientific Misconduct, the Honor Code, and requiring that they be followed.

• prepare students to be competitive for employment, by:

1. promoting free inquiry and the free exchange of information, subject to the University’s policies regarding secrecy and confidentiality of research;

2. acknowledging student contributions to research presented at conferences, in professional publications, or in applications for copyrights and patents;

3. encouraging graduate students to participate in professional meetings, perform or display their work in public settings, and publish the results of their research;

4. providing a realistic view of the field and the current job market and making use of professional contacts for the benefit of their students.

• maintain a high level of professionalism, including:

1. excusing themselves from participating in committee decisions regarding any student with whom they have a relationship that could result in a conflict of interest;

2. never impeding a graduate student’s progress toward the degree or toward employment in order to benefit from the student’s proficiency as a Teaching or Research Assistant;

3. interacting with students, staff, and faculty colleagues in a professional and civil manner, and in accordance with University policies.

B. Graduate Students should • understand faculty advisor’s central role, as well as their constraints. This includes:

1. recognizing that the faculty advisor provides the intellectual and instructional environment in which the student conducts research, and, through access to teaching and research funds, may also provide the student with financial support;

2. recognizing that the faculty advisor is responsible for monitoring the accuracy, validity, and integrity of the student’s research, and for ensuring that the contributions of all participants in the research are properly acknowledged in any publications. For these reasons and because the quality of that research reflects on the student, the faculty advisor, and the University, students should always consult with their advisors before attempting to publish the results of work carried out under the advisor’s direction and/or in the advisor’s laboratory;

3. being aware of time constraints and other demands imposed on faculty members and program staff;

4. taking the initiative to arrange meetings with the Faculty Advisor as often as necessary and to keep the advisor informed of any factors that might affect the progress of their research or time to degree. A suggested minimum is twice a semester.

• recognize the importance of seeking an early and informal resolution of any problems in their working

relationships with their advisor or others by first consulting with the advisor. • take primary responsibility for informing themselves of the regulations, policies, and practices

governing their financial aid, degree and course requirements, research activities, and conflict resolution. This may involve: 1. consulting departmental notes or guidelines for Graduate Students, the Molecular Biosciences

Graduate Student Handbook, the research policies set forth by the Office of Research and Technology Transfer, and the Graduate Student Bulletin;

2. seeking clarification from the Faculty Advisor when they are uncertain about the precise meaning or application of a regulation or policy statement.

• exercise high professional standards in all aspects of their work. This includes:

1. observing the University’s policy on scientific misconduct. This policy applies to researchers in all disciplines and to students as well as faculty and staff;

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2. maintaining absolute integrity in taking examinations and in collecting, analyzing and presenting research data;

3. taking special care to preserve the data collected during experiments or noted during research (with precise identification of sources) in order to avoid future confusion or disputes about access or ownership.

4. acknowledging the contributions of the faculty advisor and other members of the research team to the student’s work in all publications and conference presentations. It is also appropriate to acknowledge the sources of financial support. Students should familiarize themselves with the statement on Academic Authorship information provided in the MBS Graduate Handbook.

• maintain the confidentiality of the Faculty Advisor’s professional activities and research prior to

presentation or publication, in accordance with existing practices and policies of the discipline. • inform faculty of conflicts and work towards a clear resolution. • interact with faculty, staff and other students in a mature, professional, and civil manner in

accordance with University policies. C. The MBS Program should • introduce new graduate students to the policies, practices, and resources of the program by means of

an orientation session; • provide students with written documentation of program policies, designating one or more members

of the faculty as resources for graduate students and faculty to call on to help resolve conflicts. This role may be filled by the Program Director, the Graduate School Dean, or a specially designated program ombudsperson. Problems are usually resolved most quickly and effectively at the program level, but in exceptional circumstances a student may wish to consult the Graduate School.

SECTION VI. INTELLETUAL PROPERTY AND SCIENTIFIC INTEGRITY A. Academic Authorship Issues related to academic authorship, i.e., the allocation of responsibility and credit for scholarly publications, can be complex. University faculty seek to foster the intellectual growth and independence of students through authorship credit and adherence to standards for citation and acknowledgment. Where multiple authors contribute to a paper, the guidelines below should be followed: Principal Investigators and senior faculty have special responsibilities to assure the overall cohesiveness and validity of the publications on which they appear as coauthors. All authors in a group effort have a shared responsibility for the published result and should have the opportunity to review all sample preparation procedures and data, as well as all data acquisition and analysis procedures. Each author in a group effort should have access to the manuscript prior to its being submitted for publication, and should agree to his or her inclusion as a coauthor. All the participants in the program should know that the paper is being prepared for publication. Early in the project, each research group should define appropriate practices for the maintenance of data. The following discussion of Academic Authorship is extracted from a statement by Donald Kennedy, then President of Stanford University, that was circulated to faculty in September 1985: “The understanding in my laboratory was this: If I had contributed to the idea of the project and had also contributed significantly to the hands-on work, coauthorship was justified; but any coauthor had to have a complete enough grasp of the whole effort to defend it effectively in a scientific meeting”. This test, of course, is tailored to an experimental science and surely is not the only one applicable even there. Whatever the agreement, it is necessary also that there be a prior understanding of the scope of the particular project or sub-project; that is, all prospective authors should know the anticipated product to which the agreement applies.

Another aspect of the same cluster of issues (i.e., who may publish first, who must consent, what connections with the work need to be acknowledged and how) is associated particularly with review articles, books (or chapters of books), or symposium contributions, especially “state of the discipline” pieces. Where the piece deals with data or results of others that are already published as a paper or

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dissertation, or which have been accepted for publication, then employing them with appropriate citation is obviously proper.

B. Retention of/Access to Research Data Accurate and appropriate research records are an essential component of any research project. Both the University and the Principal Investigator (PI) have responsibilities and rights concerning access to, use of, and maintenance of original research data. The PI is a member of the University faculty unless the funds for the research were secured in total by the graduate student. Except where precluded by the specific terms of sponsorship or other agreements, tangible research property, including the scientific data and other records of research conducted under the auspices of Arkansas State University, belongs to the University. The PI is responsible for the maintenance and retention of research data in accord with this policy. Questions on the interpretation of this policy may be directed to the Vice Chancellor of Research and Academic Affairs.

Definitions and Applicability: This policy shall apply to all University faculty, staff, students and any other persons at the University involved in the design, conduct or reporting of research at or under the auspices of Arkansas State University, and it shall apply to all research projects on which those individuals work, regardless of the source of funding for the project. Research data include laboratory notebooks and field notes, as well as any other records that are necessary for the reconstruction and evaluation of reported results of research and the events and processes leading to those results, regardless of the form or the media on which they may be recorded. The University must retain research data in sufficient detail and for an adequate period of time to enable appropriate responses to questions about accuracy, authenticity, primacy and compliance with laws and regulations governing the conduct of the research. It is the responsibility of the Principal Investigator to determine what needs to be retained under this policy. Where research is funded by a contract with the University that includes specific provision(s) regarding ownership, retention of and access to technical data, the provision(s) of that agreement will supersede this policy.

Ownership: The University’s ownership and stewardship of the scientific record for projects conducted at the University, under the auspices of the University, or with University resources are based on both regulation (OMB Circular A-110, Sec. 53) and sound management principles. Arkansas State University’s responsibilities in this regard include, but are not limited to: • complying with the terms of sponsored project agreements; • ensuring the appropriate use of animals, human subjects, recombinant DNA, etiological agents,

radioactive materials, and the like; • protecting the rights of students, postdoctoral scholars, and staff, including, but not limited to, their

rights to access to data from research in which they participated; • securing intellectual property rights; • facilitating the investigation of charges, such as scientific misconduct or conflict of interest. Collection and Retention: The Principle Investor (PI) is responsible for the collection, management and retention of research data. Although a graduate student may work on the project, the ultimate responsibility for the research is that of the PI. PIs should adopt an orderly system of data organization and should communicate the chosen system to all members of a research group and to the appropriate administrative personnel, where applicable. Particularly for long-term research projects, PIs should establish and maintain procedures for the protection of essential records in the event of a natural disaster or other emergency. Research data must be archived for a minimum of three years after the final project close-out, with original data retained wherever possible. In addition, any of the following circumstances may justify longer periods of retention: • data must be kept for as long as may be necessary to protect any intellectual property resulting from

the work; • if any charges regarding the research arise, such as allegations of scientific misconduct or conflict of

interest, data must be retained until such charges are fully resolved; and; • if a student is involved, data must be retained at least until the degree is awarded or it is clear that the

student has abandoned the work.

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Beyond the period of retention specified here, the destruction of the research record is at the discretion of the PI and his or her department or laboratory.

Records will normally be retained in the unit where they are produced. Research records must be retained on the University campus, or in facilities under the auspices of the University, unless specific permission to do otherwise is granted by the Vice Chancellor of Research and Technology Transfer.

Access: Where necessary to assure needed and appropriate access, the University has the option to take custody of the data. When individuals involved in research projects at Arkansas State University leave the University, they may take copies of research data for projects on which they have worked. Original data, however, must be retained at the University by the Principal Investigator. If a Principal Investigator leaves Arkansas State University, and a project is to be moved to another institution, ownership of the data may be transferred with the approval of the Vice Chancellor of Research and Technology Transfer, and with written agreement from the PI’s new institution that guarantees: 1) its acceptance of custodial responsibilities for the data, and 2) Arkansas State University access to the data, should that become necessary.

C. Relationships between Students and Outside Entities As part of their University education, graduate students, as well as undergraduates and postdoctoral scholars, may establish relationships with outside entities, such as private companies or non-profit organizations (including government agencies, foundations, public action organizations, school systems, etc.). These relationships may range from student internships that are part of a formal Program of Study in Molecular Biosciences to the actual conduct of a student’s research or scholarship project at the outside entity. In addition to these activities, which are part of the student’s academic program, students may have the opportunity to serve as consultants to outside entities, independent of their academic programs at the University. All of these relationships may have considerable educational value for the student, providing unique educational or research resources and familiarizing students with the work environment of private companies or non-profit organizations. However, the establishment of these relationships with outside entities, as part of or outside the student’s academic program at the University, raises issues concerning the open vs. proprietary nature of the work, the ownership of any intellectual property that may result, and possible conflicts of commitment and interest. No student may initiate a relationship, for research purposes, between the University and a private, government, or non-profit organization. These arrangements should be made by the PI through the Office of Research and Technology Transfer.

Conflict of Commitment: Full-time University graduate students and faculty members owe their primary professional allegiance to the University, and their primary commitment of time and intellectual energies should be to the education, research and scholarship programs of the institution. The specific responsibilities and professional activities that constitute an appropriate and primary commitment will differ across departments within the MBS program, but they should be based on a general understanding between the student, faculty member, their department chair, their College Dean, and the MBS Program Director.

Conflict of Interest: A conflict of interest occurs when there is a divergence between an individual’s private interests and his or her professional obligations to the University such that an independent observer might reasonably question whether the individual’s professional actions or decisions are determined by considerations of personal gain, financial or otherwise. A conflict of interest depends on the situation, and not on the character or actions of the individual. Conflicts of interest are common and practically unavoidable in a modern research university. At Arkansas State University, conflicts of interest can arise out of the fact that a mission of the University is to promote public good by fostering the transfer of knowledge gained through University research and scholarship to the private sector. Two important means of accomplishing this mission include faculty consulting and the commercialization of technologies derived from faculty and student research. It is appropriate that faculty and student be rewarded for their participation in these activities through consulting fees and sharing in royalties resulting from the commercialization of their work. It is wrong, however, for an individual’s actions or decisions made in the course of his or her University activities to be determined by considerations of personal financial gain. Such behavior calls

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into question the professional objectivity and ethics of the individual and it also reflects negatively on the University. Arkansas State University is an institution of public trust; faculty must respect that status and conduct their affairs in ways that will not compromise the integrity of the University. Graduate students and MBS faculty will conduct their affairs so as to avoid or minimize conflicts of interest, and must respond appropriately when conflicts of interest arise. (If a situation raising questions of conflict of commitment or interest arises, faculty and students are urged to discuss the situation with the MBS program director, their department chair, College dean, or the Vice Chancellor of Research and Technology Transfer).

Policy on Allegations, Investigations and Reporting: As its title indicates, the MBS policy on scientific misconduct focuses on problems that sometimes arise in the conduct of research in the sciences and engineering. However, its fundamental principles of honesty and conscientious observance of good research practices apply to scholarship across the University and to students as well as faculty and staff. These principles are articulated in the paragraphs below. Each member of the MBS community has a responsibility to foster an environment which promotes intellectual honesty and integrity, and which does not tolerate misconduct in any aspect of research or scholarly endeavor. Scientific misconduct is extremely troubling, in spite of its infrequency, because when it occurs, it is very destructive of the standards we attempt to instill in our students, of the esteem in which academic science in general is held by the public, and of the financial support of the government and other sponsors for academic scientific enterprise. The importance of integrity in research cannot be overemphasized.

D. Scientific Misconduct “Scientific misconduct” is defined as fabrication, falsification, plagiarism, or other practices that seriously deviate from those commonly accepted within the scientific community in proposing, performing, or reviewing research, or in reporting research results. It does not include honest error or honest differences in interpretations or judgments of data. Also included as “scientific misconduct” for this purpose is retaliation of any kind against a person who, acting in good faith, reported or provided information about suspected or alleged misconduct. The MBS policy addresses only scientific misconduct. The Program’s statement on faculty discipline has been interpreted to include such other violations as reckless disregard for accuracy, failure to supervise adequately, and other lapses from professional conduct or neglect of academic duties. Allegations or suspicions of misconduct outside the scope of this policy should be directed to the cognizant Dean or Vice Chancellor for investigation, although the process of investigation and reporting obligations may differ from those required for scientific misconduct cases.

Determination of Discipline: The determination as to whether discipline is to be imposed is governed by existing policies. In cases involving faculty, sanctions may only be imposed through the faculty disciplinary process. The MBS Program Director will refer cases of significant student misconduct to the Dean of the Graduate School. Cases involving faculty or staff members will be referred to the appropriate administrator (i.e., department chair or College Dean).

Cautions and Assistance The gathering and assessing of information in cases of alleged scientific misconduct can be extremely difficult. It is essential to protect the professional reputations of those involved, as well as the interests of the public and of any who might be harmed by the alleged misconduct. In the course of conducting inquiries or investigations, the following provisions are applicable: Expert assistance should be sought as necessary to conduct a thorough and authoritative evaluation of all evidence. Precautions should be taken to avoid real or apparent conflicts of interest on the part of those involved in the inquiry or investigation. The anonymity of accused individuals and, if they wish it, the confidentiality of those who in good faith reported the alleged misconduct, should be protected as much as possible, and care should be taken to protect their positions and reputations. Except as required in the reporting provisions above, only those directly involved in an inquiry or investigation should be aware that the process is being conducted or have any access to information obtained during its course. Where appropriate, efforts should be made to restore the reputations of those accused when allegations are not confirmed. Questions on the interpretation of this policy should be directed to the Office of Research and Technology Transfer or the Graduate School.

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E. MBS Graduate Student Publication/Presentation Policy Upon acceptance into the program, all Graduate Students in the Arkansas State University Molecular Biosciences Program automatically agree to abide by the policy that their advisor, with input by their PhD Advisory Committee and/or MBS Program Director as deemed applicable, will exercise purview and controlling interest over all data and scientific inquiry obtained or performed by said student, and all conclusions, ramifications, or benefits arising from such data or inquiry. The advisor will also exercise such over all research or scholarship, dissemination, conference attendance, professional consulting or outside employment, and public appearances by the student in any role related at all to his participation in any capacity in the Molecular Biosciences Program. All MBS graduate students will sign an intellectual property agreement within the first week of residence. In general, students will not pursue opportunities for dissemination or other professional or public activities without the full knowledge, agreement, and appropriate degree of participation by the advisor. Specifically, students will not independently pursue other secondary scholarly investigation, other than routine course activities, or dissemination over any topic with other faculty or students at the University or elsewhere without the advisor’s prior full approval and appropriate degree of participation, for example co-authorship. Conversely, advisors and other faculty will respect the student’s contribution to the total research effort and grant the student appropriate credit, opportunities, and benefits for the contribution. All parties should always keep in mind that they are ambassadors for the program and examples for others and should always strive to abide by a high-level of scientific integrity and professionalism.

Appendix B

Curriculum Vitae of MBS “Core Faculty”

CURRICULUM VITAE SOOHYOUN AHN

Assistant Professor in Food Science and Technology College of Agriculture

Arkansas State University P.O. BOX 1080

State University, AR 72467 Phone: (870) 972-2802 Email: [email protected]

EDUCATION

Ph. D. in Food Science and Technology, March 2003 Cornell University, Ithaca, NY

Specialization: Food microbiology and bio-analysis Minors: Biochemistry, Microbiology

M. S. in Food Science and Biotechnology, February 1998 Yonsei University, Seoul, South Korea

Specialization: Food Microbiology

B. S. in Food Science and Technology, February 1996 Yonsei University, Seoul, South Korea

WORK EXPERIENCE

Adjunct Faculty in Food Science, July 2007 to present Department of Food Science, University of Arkansas, Fayetteville, AR

Appointed Faculty in Agriculture Research, July 2007 to present

University of Arkansas Division of Agriculture, Jonesboro, AR

Assistant Professor (joint appointment), August 2006 to present Molecular Diagnostics in Foods, Arkansas Biosciences Institute, Jonesboro, AR

Assistant Professor, August 2006 to present Food Science Program, College of Agriculture, Arkansas State University, Jonesboro, AR

Postdoctoral Associate, September 2005 to July 2006 School of Molecular Biosciences, Washington State University, Pullman, WA

Postdoctoral Associate, April 2003 to September 2005 Department of Chemistry, Tufts University, Medford, MA

Graduate Research Assistant, August 1999 to December 2002 Department of Food Science and Technology, Cornell University, Ithaca, NY

Laboratory Technician, March 1998 to July 1998 Korean Federation of Culture Collections, Seoul


TEACHING EXPERIENCE

Assistant Professor, August 2006 to present Food Science Program, College of Agriculture, Arkansas State University, Jonesboro, AR

“Food Chemistry” “Food and Health” “Food Quality Assurance” “Introductory Food Science” “Principles of Food Processing” “Practicum in Food Technology” (internships and professional experiences)

“Special Problems; Food Quality and Safety”

Biology Program, Department of Biology, Arkansas State University, Jonesboro, AR “Biology of the Cell” “Biology of the Cell – lab”

Interdisciplinary Molecular Biosciences Graduate Program, Arkansas State University, Jonesboro, AR “Advanced Cell Biology” “Molecular Genetics and Genomics” “Topics in Molecular Biology”

Guest Lectures, College of Agriculture, Arkansas State University, Jonesboro, AR “Feeding the Planet” “Seminar: Making Connections”

Postdoctoral Associate March 2006

School of Molecular Biosciences, Washington State University, Pullman WA Guest lecture, “Medical Microbiology”

November 2005 Department of Civil and Environmental Engineering, Tufts University, Boston, MA

Invited lecture, “Biology of Water and Health” Graduate Teaching Assistant

January 1999 to June 1999 Department of Food Science, Cornell University, Ithaca, NY

“Understanding Wine”

March 1996 to February 1998 Department of Food Science and Biotechnology, Yonsei University, Seoul, South Korea

“Biochemistry” “Advanced Biochemistry” “Laboratory in Food Microbiology” “Laboratory in Food Science”


RESEARCH EXPERIENCE

Current Research Interests • Developing DNA microarray system for simultaneous detection of multiple foodborne pathogens and

biological toxins • Developing an organizing system for food tracking/traceability • Developing portable biosensor system to detect pathogens and biological toxins for field application • Evaluation of sterilization/cleaning method for fresh produce to prevent microbial contamination

Post-doctoral Research

Location: School of Molecular Biosciences, Washington State University, Pullman, WA Advisor: Dr. Michael E. Konkel • Studying pathogenesis of Campylobacter jejuni in human epithelial cells • Developing gene expression array for Campylobacter jejuni grown in different conditions • Performing RT-PCR to study expression of virulence genes in Campylobacter jejuni in different

growth time-course and different conditions Location: Department of Chemistry, Tufts University, Medford, MA Advisor: Dr. David R. Walt • Developed fiber optic-based microarray for detection of food or water pathogens causing infectious

diseases, and microarray for detection of harmful algal bloom species • Developed multiplexed high-density arrays for multiple bio-warfare agents. • Developed universal arrays for gene expression and array for serotyping of Listeria monocytogenes • Developed multi-disease detection system from clinical samples (saliva sample)

Doctoral Research

Location: Department of Food Science & Technology, Cornell University, Ithaca, NY Dissertation: “Development of bioassays using ganglioside-liposomes for detection of biological toxins” Advisor: Dr. Richard A. Durst Co advisors: Dr. David B. Wilson and Dr. Randy W. Worobo • Developed test-strip immunoassay for detection of biological toxins using ganglioside-liposomes • Developed detection assay for E.coli O157:H7 and Salmonella detection from environmental water

using immunoliposomes and immunomagnetic beads • Purified bacteriocins and antimicrobials produced by bacteria and cloned their encoding genes

Master’s Research

Location: Department of Food Science and Biotechnology, Yonsei University, Seoul, South Korea Thesis: “Purification and characterization of halophilic protease produced by bacteria isolated from Korean traditional fermented food” Advisor: Dr. Ju-Hyun Yu, Dr. Sang-Kyou Lee, and Dr. Doo-Hwan Oh (deceased) • Screened protease-producing halophilic bacteria from food samples • Purified and characterized bacterial proteins • Cloned bacterial genes encoding chitinase and chitosanase


AWARDS and HONORS

Institute of Food Technologists (IFT) annual meeting, student paper competition (Toxicology & Safety evaluation division), 1st winner, 2003.

IAEAC workshop on biosensors and biological techniques in environmental analysis, poster competition, 1ST winner, 2002.

Cornell University, Ithaca, NY, graduate research assistantship, 1999-2003. Yonsei University Highest Honors, 1996 Yonsei University Presidential Honors, 1994, 1995, 1996

ACADEMIC SOCIETIES

Memberships • American Society for Microbiology, 2007 – present • American Chemical Society, 2006 – present • Northeast Arkansas-Association for Women in Science, 2006 – present • International Association for Food Protection, 2006 – present • IFT Mid-South Section, 2006 – present • IFT Biotechnology subdivision, 2005 – present • IFT Food Microbiology subdivision, 2003 – present • IFT Toxicology and Safety Evaluation subdivision, 2003 – present • Institute of Food Technologists (IFT), 2001 – present • American Dairy Science Association, 1999 – 2001

Services

• Member of The Science Advisory Board, 2007 – present • Reviewer for Scientific Journals International, 2007 – present • Advisory Board Member of Scientific Journals International, 2007 – present

- “Agriculture, Botany, Zoology, Food, Ecology, and Environmental Sciences” section • Reviewer for Journal of Agriculture, Food and Environmental Sciences, 2007 – present • Reviewer for Journal of Food Quality, 2007 – present • Reviewer for Journal of Food Biochemistry, 2007 – present

PEER-REVIEWED PUBLICATIONS

“Campylobacter jejuni invade chicken LMH cells inefficiently and stimulate differential expression of the chicken CXCLi1 and CXCLi2 cytokines”, C. L. Larson, D. H., Shah, A. S. Dhillon, D. R. Call, S. Ahn, G. J. Haldorson, C. Davitt, and M. E. Konkel, Microbiology, 2008. 154, 3835-3847.

“Detection of cholera toxin in seafood using a ganglioside-liposome immunoassay”, S. Ahn and R. A. Durst,

Analytical and Bioanalytical Chemistry, 2008, 391, 473-478.


PEER-REVIEWED PUBLICATIONS (continued)

“Fiber-Optic Microarray for Simultaneous Detection of Harmful Algal Bloom Species Using Sandwich-Hybridization”, S. Ahn, D. M. Kulis, D. L. Erdner, D. M. Anderson, and D. R. Walt, Applied and Environmental Microbiology, 2006, 72, 5742-5749.

“Fiber optic microarrays for the detection and enumeration of harmful algal bloom species”, D. M. Anderson,

D. Kulis, D. Erdner, S. Ahn, and D. Walt, In G. C. Pitcher, T. A. Probyn, and H. M. Verheye (eds). 11th International Conference on Harmful Algae, Cape Town, South Africa. November 2004. Special issue of South African Journal of Marine Science, 2006, 28, 231-235.

“Fiber-optic microsphere-based arrays for multiplexed biological warfare agent detection”, L. Song, S. Ahn

and D. R. Walt, Analytical Chemistry, 2006, 78, 1023-1033. “Detecting biological warfare agents”, L. Song, S. Ahn and D. R. Walt. Emerging Infectious Diseases. 2005,

11:1629-1632. “Detection of Salmonella spp. using microsphere-based, fiber-optic DNA array”, S. Ahn and D. R. Walt,

Analytical Chemistry, 2005, 77, 5041-5047. “Ganglioside-liposome immunoassay for the detection of botulinum toxin”, S. Ahn-Yoon, T. R. DeCory, and R.

A. Durst, Analytical and Bioanalytical Chemistry, 2004, 378, 68-75. “Ganglioside-liposome immunoassay for the ultrasensitive detection of cholera toxin”, S. Ahn-Yoon, T. R.

DeCory, A. J. Bauemner, and R. A. Durst, Analytical Chemistry, 2003, 75, 2256-2261.

“Detection of femto-/attomolar concentration of botulinum neurotoxin and cholera enterotoxin using ganglioside-nanovesicle immunoassay”, R. A. Durst, S. Ahn, T. R. DeCory, and A. J. Bauemner, 2003, Proceedings of the institute of biological engineering.

“Development of capillary migration strip assay using ganglioside-incorporated liposomes for detection of

biological toxins”, S. Ahn-Yoon, T. R. DeCory, and R. A. Durst, 2002, Proceedings of the IAEAC 5th workshop.

PAPERS PRESENTED AT MEETINGS

"Detection of E. coli O157:H7 and Salmonella spp. using PCR and fiber-optic DNA microarray”, S. Ahn, L. Song and D. R. Walt, Food Safety Consortium 2006 Symposium, Fayetteville, AR, Oct. 1-3, 2006 (Invited presentation)

"Development of bio-assays using ganglioside-liposomes for detection of biological toxins”, S. Ahn, T.R.

DeCory and R. A. Durst, Food Safety Consortium 2006 Symposium, Fayetteville, AR, Oct. 1-3, 2006 (Invited presentation)


PAPERS PRESENTED AT MEETINGS (continued)

"An overview of biophotonic & fiber optic sensing in the Walt laboratory at Tufts University”, D. J. Monk, S. Ahn, S. Bencic-Nagale, Y. Kuang, L. Song, D. R. Walt, OIDA Biophotonic Sensors and Smart Fiber Optic Sensor Networks Workshop, Rochester, NY, Aug. 17-18th, 2005 (Invited talk)

“Detection of Escherichia O157:H7 and Salmonella spp. using PCR and fiber-optic DNA microarray”, S. Ahn,

L. Song, and D. R. Walt, Pittcon annual meeting, Orlando, FL; Feb 28 -March 5, 2005. (Oral presentation) “Detection of harmful algae bloom species using fiber-optic microarrays”, S. Ahn and D. R. Walt, Pittcon

annual meeting, Orlando, FL; Feb 28-March 5, 2005. (Oral presentation) “Fiber optic microarrays for the detection and enumeration of harmful algal bloom species”, D. Anderson, D.

Kulis, D. Erdner, S. Ahn and D. R. Walt, 11th International conference of harmful algae, Cape Town, South Africa; Nov 2004. (Plenary speaking)

“Detection of Salmonella spp. using fiber-optic DNA microarray”, S. Ahn and D. R. Walt, IFT annual meeting,

Las Vegas, NV; July 2004, Technical oral presentation in food microbiology division. “Development of bio-assays using ganglioside-liposomes for detection of biological toxins”, S. Ahn, T. R.

DeCory, and R. A. Durst, IFT annual meeting, Anaheim, CA; June 2003, Technical poster presentation in toxicology & safety evaluation division.

“Development of capillary migration strip assay using ganglioside-incorporated liposomes for detection of

biological toxins”, S. Ahn, T. R. DeCory, and R. A. Durst, IAEAC 5th workshop on biosensors and biological techniques in environmental analysis, Ithaca, NY; May-June 2002. (Poster presentation)

“Rapid bioassay using ganglioside-liposomes for the detection of botulinum and cholera toxin”, S. Ahn, T. R.

DeCory, and R. A. Durst, IAEAC 5th workshop on biosensors and biological techniques in environmental analysis, Ithaca, NY; May-June 2002. (Oral presentation)

PATENTS “A new halophilic protease and a new bacterium which produces the enzyme”, Korean Patent No.10-1998-

0009547, Mar 1998, S. Ahn, H. S. Lee, S. W. Choi, I H. Yeo, D. H. Bae, D. H. Oh, and J. H. Yu. FUNDING AND GRANTS FOR RESEARCH ACTIVITIES

“Molecular technology in food microbiology III” (Principal investigator), Arkansas Biosciences Institute, $17,385.60, July 2008 – June 2009.


FUNDING AND GRANTS FOR RESEARCH ACTIVITIES (continued) “Development of bioassays using liposomes for detection of pathogens and biological toxin from foods”

(Principal investigator), Arkansas State University – ASU Faculty Research Award, $8,900.00, July 2008 – June 2009.

“Molecular-based diagnostics of foodborne pathogens” (Principal investigator), USDA-CRIS – Arkansas

Agricultural Experiment Station, $50,000.00, July 2007 – June 2012.

“Undergraduate research and mentoring in the biological sciences – Cross disciplinary research at the interface of biotechnology and the environment” (Collaborator), National Science Foundation (NSF), $810,170.00, January 2008 – January 2013.

“Multiplexed detection of foodborne pathogens using bead-based DNA microarrays” (Principal investigator),

Arkansas State University – ASU Faculty Research Award, $5,178.00, July 2008 – June 2009.

“Molecular technology in food microbiology II” (Principal investigator), Arkansas Biosciences Institute, $17,916.80, July 2007 – June 2008.

“Molecular technology in food microbiology I” (Principal investigator), Arkansas Biosciences Institute,

$36,190.66, Mar 2007 – June 2007.

“Establishment of Food Science and Technology Education – Development of Associate degree program” (Principal investigator), College of Agriculture, Arkansas State University, $30,000.00, July 2006 – June 2009.

SKILLS

Microarray development; immunoassay (including ELISA); biosensors including DNA sensors and immuno-sensors; cell-based assays; pathogen detection assay development; molecular diagnostics; probe/primer design; bacterial cell culture; tissue culture; PCR; RT-PCR; real-time PCR; protein purification; immunoblotting; Western blot; Southern blot; cloning


REFERENCES

Dr. Gregory C. Phillips Dean of the Colleges of Agriculture; Engineering; Sciences and Mathematics College of Agriculture Arkansas State University P.O. BOX 1080 State University, AR 72467 Email: [email protected] Phone: (870) 972-2375

Dr. Carole L. Cramer

Executive Director of Arkansas Biosciences Institute Arkansas Biosciences Institute Arkansas State University P.O. BOX 639 State University, AR 72467 Email: [email protected]

Phone: (870) 972-2025 Dr. David R. Walt

Robinson Professor of Chemistry Tufts University Department of Chemistry 62 Talbot Avenue Medford, MA 02155 Email: [email protected] Phone: (617) 627-3470

Dr. Richard A. Durst Professor Cornell University (NYSAES) Department of Food Science and Technology Geneva, NY 14456 Email: [email protected] Phone: (315) 787-2297

mailto:[email protected]




CURRICULUM VITAE ROGER A. BUCHANAN, PH.D. DEPARTMENT OF BIOLOGICAL SCIENCES, ARKANSAS STATE UNIVERSITY Associate Professor of Biology Biological Sciences PHONE 870 680-4297 P.O. Box 599 FAX 870 680-4347 Arkansas State University E-MAIL [email protected] State University, Arkansas 72467

EDUCATION 1992 MBL Post-Doctoral Fellow Marine Biological

Lab (Woods Hole, MA) 1990-1992 National Institutes of Health, Bethesda, MD IRTA Postdoctoral Fellow (Laboratory of Neurobiology) 1990 University of Delaware, Newark DE Postdoctoral Fellow 1985-1990 University of Delaware Ph.D. (Cell Biology) 1981 University of Delaware B.A. (Biology)

ACADEMIC POSITIONS 2008- Present Judd Hill Endowed Chair of BioTechnology Arkansas State University 2007- present Professor of Zoology Arkansas State University 1996-2007 Associate Professor of Zoology Arkansas State University 1992-1996 Assistant Professor of Zoology Arkansas State University 1985-1988 Graduate Teaching Assistant University of Delaware 2003-Present Adjunct Associate Professor, Department of Neurobiology and Developmental Sciences University of Arkansas for Medical Sciences 2007 Affiliate Scientist, Nanotechnology Center University of Arkansas at Little Rock

ADMINISTRATION 2008-Present Director, Molecular BioSciences Program Arkansas State university 1998-2002 Chair, Department of Biological Sciences Arkansas State University 1999-2000 Interim Director, Environmental Sciences Program Arkansas State University

ADVISORY BOARDS AND STEERING COMMITTEES 2000-Present Arkansas Biomedical Research Initiative Network Steering Committee (AR

INBRE). Oversees the distribution of over $8,000,000 in NIH funding to Arkansas colleges and universities

1999-Present Member, Arkansas Watershed Advisory Group. Provides assistance and expertise to individuals and watershed groups seeking assistance in ensuring the water quality of Arkansas’ streams, lakes and rivers.

2000-Present Member, Arkansas Department of Soil and Water Conservation Commission NonPoint Source Pollution Support Group.

1999-2005 Technical Advisor to the L’Anguille River Watershed Project (Cross, Crittenden and Phillips counties, AR).

COURSES TAUGHT (SINCE 2000) Topics in Molecular Bioscience Responsible Conduct in Research

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Human Functions and Structure 1 & 2 Human Functions and Structure 1 & 2 Labs Animal Physiology Animal Physiology Lab Human Anatomy and Physiology 1 & 2 Human Anatomy and Physiology 1 & 2 Labs Cell Biology Cell Biology Lab Mammalian Neurobiology Comparative Anatomy JOURNAL REVIEWER

Analytical and Bioanalytical Chemistry

PATENT PENDING Ref No. 170007, SSN: 12/036,509, Application serial number 60/891,684 "Method and apparatus to detect chemical vapors"

PEER REVIEWED PAPERS (Since 1996) Jennifer L. Bouldin, Taylor M. Ingle, Regina Alexander, Roger A. Buchanan, 2008 Absorption of

Semiconductor Nanocrystals by the Aquatic Invertebrate Ceriodaphnia dubia. Bulletin of Environmental Contamination and Toxicology 27(9):1958-1963.

Jennifer L. Bouldin, Taylor M. Ingle, Anindita Sengupta, Regina Alexander, Robyn E. Hannigan, Roger A. Buchanan, 2008. Aqueous toxicity and food chain transfer of quantum dots in freshwater algae and Ceriodaphnia dubia. Environmental Toxicology and Chemistry 81(3):249-252.

Akash Shah and Roger Buchanan, 2008. Localization of Nicotine-Sensitive Cells in the Brainstem. Journal for Young Investigators 18(2):47-52.

Ingle, Taylor; Hannigan, Robyn; Buchanan, Roger; and Bouldin, Jennifer. 2007. Detection, measurement and toxicology of semiconductor nanocrystals in Ceriodaphnia dubia. Proceedings of NSTI Nanotechnology 2007 2:612-616.

E. Garcia-Rill, R. Buchanan, K. McKeon, R.D. Skinner and T. Wallace, 2007. Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems. Neurotoxicology 28(5):915-923.

Edgar Garcia-Rill, Cameron H Good; Kevin D Bay; Roger Buchanan, Robert D Skinner. Muscarinic and nicotinic responses in the developing pedunculopontine nucleus (PPN), 2007. Brain Research 1129:147-155.

Smolinski TG, Boratyn GM, Milanova M, Buchanan R, and Prinz AA, 2006. Hybridization of Independent Component Analysis, Rough Sets, and Multi-Objective Evolutionary Algorithms for Classificatory Decomposition of Cortical Evoked Potentials. Proc. of the 2006 Workshop on Pattern Recognition in Bioinformatics 2006 (PRIB 2006), Lecture Notes in Bioinformatics 4146:174-183.

CH Good, KD Bay, RA Buchanan, KA McKeon, RD Skinner and E Garcia-Rill, 2006. Prenatal exposure to cigarette smoke affects the physiology of pedunculopontine neurons in development. Neurotoxicology and Teratology, 28(2):210-9.

Mamiya N, RA Buchanan, RD Skinner and E Garcia-Rill, 2005. Nicotine suppresses the P13 auditory evoked potential by acting on the pedunculopontine nucleus in the rat. Exp Brain Res, 164(1):109-119 3 Citations

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http://www.springerlink.com/content/101156/


Pozzo-Miller LD, NB Pivovarova, RD Leapman, RA Buchanan, TS Reese and SB Andrews, 1997. Activity-dependent Calcium Sequestration in Dendrites of Hippocampal Neurons in Brain Slices. Journal of Neuroscience 17(22):8729-8738. 48 citations

Trauth, SE and RA Buchanan, 1997. Characterization of Spermatazoa of the Lizard Cnemidophorus sexlineatus Using Fluorescence Microscopy. Journal of Herpetology 31(1):98-102.

CONFERENCE PROCEEDINGS, BOOK CHAPTERS AND INVITED CONTRIBUTIONS (Since 1996) Ingle T, Hannigan R, Buchanan R and J Bouldin, 2007. Detection, Measurement and Toxicology of

Semiconductor Nanocrystals in Ceriodaphnia dubia. Proceedings of NSTI Nanotechnology 2007 2:612-616. (Peer-reviewed).

Smolinski, T.G., Buchanan, R., Boratyn, G.M., Milanova, M., and Prinz A.A., 2006. “Independent Component Analysis-Motivated Approach to Classificatory Decomposition of Cortical Evoked Potentials,” BMC Bioinformatics, 7 (Suppl 2):S8, 2006. 1 citation

McMickle A and R Buchanan, 2006. Stop and Investigate (invited response to “Protocol Review”) Lab Animal 35(10):15-18.

Tomasz G. Smolinski, Mariofanna Milanova, Grzegorz M. Boratyn, Roger Buchanan, and Astrid A. Prinz, 2006. Multi-Objective Evolutionary Algorithms and Rough Sets for Decomposition and Analysis of Cortical Evoked Potentials. Proceedings of the IEEE International Conference on Granular Computing (GRC 2006) 2006:635-638.

PUBLISHED ABSTRACTS (Since 1996; Student authors and co authors are italicized) K Huber, K McKinney, E Weiss, K Blackwood, P Scrape, S Ali, and RA Buchanan, 2008. Maternal

Cigarette Smoke Exposure and Methamphetamine: Effects on monoamine concentrations in PND 30 and 60 rat pups. Neuroscience Abstracts 34:In Press.

Sonali Gera, Roger Buchanan, and Robyn Hannigan, 2008. Trace element chemistry of human teeth—leaching of metals from dental amalgam. 2008 Meeting of the Geological Society of America 40(6):249.

Taylor Ingle, David Clarke, Robyn Hannigan and Roger Buchanan, 2008. Headspace-Chromatography Mass-Spectrometry Detection and Quantification of Nicotine and Organic Substances in Serum. 2008 Annual Meeting of the American Association of Pharmaceutical Scientists, In Press

David Clarke, N Gupta, Vipin Nair, Boyd Haley, Roger Buchanan and Robyn Hannigan, 2008. Porphyrin Profiling of Rats Exposed to Inorganic Mercury and a Novel Chelation Agent. 2008 Annual Meeting of the American Association of Pharmaceutical Scientists, In Press

David Clarke, Paula Williamson, Lindsey Beall, N Gupta, Roger Buchannan, Robyn Hannigan , 2007. Effect of a novel mercury chelator on mercury excretion and distribution in rats exposed to inorganic mercury. 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry Abstracts, 28:69

Taylor M. Ingle, Leonette O. Cox, Robyn E. Hannigan and Roger A. Buchanan, 2007. Detection and measurement of semiconductor nanocrystals in aqueous solutions using DRC-ICP-MS. 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry Abstracts, 28:67

K. A. McKeon, B. L. Robinson, P.D. Williamson, S. F. Ali, R. A. Buchanan, 2007. Significant changes in monoamine turnover rates in postnatal rat brains are associated with in-utero exposure to cigarette smoke. Neuroscience Abstracts 33:38.4

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Bouldin, J. L., Ingle, T.M., Cox, L.O., Buchanan, R.A., Hannigan, R.E. 2007. Toxicological Effects of Nanoparticles as Measured with Standard Laboratory Biomonitoring. 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry Abstract, 28:67.

K Mckeon, E Weiss, K Nicholson, P Williamson, S Ali and R Buchanan, 2007. Changes in regional brain concentrations and turnover rates of dopamine, serotonin and their metabolites associated with maternal exposure to cigarette smoke in rats. Proceedings of the 6th Annual Conference of the Internationals Society for the Prevention of Tobacco induced Diseases 6:51.

JL Bouldin, T Ingle, L Cox, R Buchanan, RE Hannigan, 2006. Toxicological effects of nanoparticles as measured with standard laboratory biomonitoring. Proceedings of the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry 27:P819

M Milanova, TG Smolinski, RA Buchanan, GM Boratyn, and AA Prinz, 2006. Using classificatory decomposition to determine the influence of in utero exposure to nicotine on auditory evoked potentials recorded from the rat cerebral cortex. Neurosci Abst 32:836.02

KA McKeon, B Robinson, SF Ali, RA Buchanan, 2006. Changes in regional brain concentrations of dopamine, serotonin and their main metabolites associated with maternal exposure to cigarette smoke in rats. Neurosci Abst 32:416.07

oy Roger Buchanan, Mariofanna Milanova, Tomasz G Smolinski, Grzegorz Boratyn and Astrid A

Prinz, 2006. Decomposition and Analysis of Cortical Evoked Potentials using ICA. Proceedings of the MidSouth Computational Biology and Bioinformatics Society.

Pate M, T Jackson, K McKeon, RD Skinner, E Garcia-Rill, and R. Buchanan, 2005. Effects of 17β-estradiol on P13 potential amplitude and habituation in ovariectomized rats. Neurosci Abst 31:683.2

Good, CH, KD Bay, RA Buchanan, KA McKeon, RD Skinner and E Garcia-Rill, 2005. Nicotine (NIC) expo sure in utero affects postnatal firing properties in the pedunculopontine nucleus (PPN). Neurosci Abst 31:684.1.

McKeon K, R. Skinner, E Garcia-Rill, R Buchanan, 2005. Effects of cigarette smoke on P13 potential amplitude and habituation in rats. Neurosci Abst 31:1028.15

Ingle, T, N Enger-Luster, R Alexander, J Farris and R Buchanan, 2005. Nanoparticle absorption by the aquatic invertebrate, Ceriodaphnia dubia. Proceedings of the 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry 26:P381.1.

Mamiya N, Buchanan R, Wallace T, Skinner RD, Garcia-Rill E, 2004 Novel site of action for nicotine: inhibition of pedunculopontine (PPN) output, blockade by mecamylamine. Associated Professional Sleep Societies Annual Meeting, Sleep 27:A21.

Pate M, Skinner RD, Garcia-Rill E and Buchanan R, 2004. Changes in P13 amplitude and habituation during the reproductive cycle of female rats. 34th Annual Meeting of the Society for Neuroscience, Neurosci Abst 30:546.9.

Mamiya N, R. Buchanan, R. D. Skinner and E. Garcia-Rill, 2004. Inhibition of pedunculopontine (PPN) output by 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) in the rat. 34th Annual Meeting of the Society for Neuroscience, Neurosci Abst 30:546.11

Mamiya, N, R Buchanan, R Skinner and E Garcia-Rill, 2003. Novel Site of Action for Nicotine: Inhibition of Cholinergic Pedunculopontine (PPN) Output. 33rd Annual Meeting for the Society for Neuroscience. Neurosci Abst 29:387.4

PRESENTATIONS AT INTERNATIONAL MEETINGS (Student presenters and coauthors are italicized)

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K Huber, K McKinney, E Weiss, K Blackwood, P Scrape, S Ali, and RA Buchanan, 2008. Maternal Cigarette Smoke Exposure and Methamphetamine: Effects on monoamine concentrations in PND 30 and 60 rat pups. 38th Annual Meeting of the Society for Neuroscience, Nov 15-19, 2008, Washington DC.

David Clarke, N Gupta, Vipin Nair, Boyd Haley, Roger Buchanan and Robyn Hannigan, 2008. Porphyrin Profiling of Rats Exposed to Inorganic Mercury and a Novel Chelation Agent. 2008 Annual Meeting of the American Association of Pharmaceutical Scientists, Nov 16-20, 2008 Atlanta, GA

Taylor Ingle, David Clarke, Robyn Hannigan and Roger Buchanan, 2008. Headspace-Chromatography Mass-Spectrometry Detection and Quantification of Nicotine and Organic Substances in Serum. 2008 Annual Meeting of the American Association of Pharmaceutical Scientists, Nov 16-20, Atlanta, GA

Horton, Matthew, Al Romero, Roger Buchanan, Robyn Hannigan, 2008. Comparison of Thermoelectrically Cooled Cryocell Assisted LA-ICP-MS and Liquid ICP-MS Analysis of Metals in Kidney and Liver Samples from Beached Porpoise Carcass. Poster presented at the 35th Federation of Analytical Chemistry and Spectroscopy Societies Conference, Reno, NV.

Sonali Gera, Roger Buchanan, and Robyn Hannigan, 2008. Trace element chemistry of human teeth—leaching of metals from dental amalgam. Platform presentation at the 2008 Meeting of the Geological Society of America, Houston, TX Oct 5-9, 2008..

Taylor Ingle, Leonette Cox, Kenton Leigh, Marisa Wawrzyniak, Robyn Hannigan, Roger Buchanan, 2008. Use of Dynamic Reaction Cell™ Inductively Coupled Plasma Mass Spectrometry (DRC ICP-MS) to Detect and Measure Cadmium in Tissues of Mice that Inhaled Semiconductor Nanocrystals. 2nd Biennial National INBRE Conference, Washington DC August 2008.

K McKinney, KA Huber, KC Blackwood1, P Scrape, B Radin, S Holland, SF Ali, RA Buchanan, 2008. Effects of Exposure to Cigarette Smoke and Methamphetamine on Monoamine Neurotransmitter Concentrations in Rats. 2nd Biennial National INBRE Conference, Washington DC August 2008.

Jennifer L. Bouldin, Taylor M. Ingle, Anindita Sengupta, Regina Alexander, Robyn E. Hannigan and Roger A. Buchanan, 2008. Aqueous toxicity and food chain transfer of fluorescent nanocrystals in freshwater algae and Ceriodaphnia dubia. North American Benthological Society 56th Annual Meeting. Salt Lake City, Utah, May 2008.

Taylor M. Ingle, Leonette O. Cox, Robyn E. Hannigan and Roger A. Buchanan, 2008. Detection and measurement of semiconductor nanocrystals in aqueous solutions using DRC-ICP-MS. PITTCON 2008, New Orleans, LA March 2008.

David Clarke, Robyn Hannigan and Roger Buchanan, 2008. “Speciation of Organometals using GC-coupled to a plasma MS through a custom made transfer line”. Poster at 2008 Winter Conference on Plasma Spectrochemistry, Temecula, CA, Jan 2008

T Ingle, D Clarke, R Hannigan and Roger Buchanan, 2007 “Measurement of Nicotine in Serum Using Headspace Trap Gas-Chromatography Mass-Spectrometry” Platform presentation at PITTCON 2007. Chicago, IL

M Horton, J Stirrat, R Buchanan, and R Hannigan, 2007. “Use of cryocell assisted LA-ICP-MS to detect semiconductor nanocrystals metals accumulated in tissues of exposed animals” Poster at PITTCON 2007. Chicago, IL

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R Buchanan, T Ingle, J Stirrat, K Trammel, N Reed, and R Hannigan, 2007. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) detection of cadmium in animals exposed to semiconductor nanocrystals” Platform presentation at PITTCON 2007. Chicago, IL

L Heard, M Hoskett, R Buchanan and R Hannigan, 2007. Rapid GC-MS detection of drugs of abuse. Poster at PITTCON 2007. Chicago, IL

David Clarke, Paula Williamson, Lindsey Beall, N Gupta, Roger Buchannan, Robyn Hannigan , 2007. Effect of a novel mercury chelator on mercury excretion and distribution in rats exposed to inorganic mercury. 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry. Nov, 2007. Milwaukee, WI..

Taylor M. Ingle, Leonette O. Cox, Robyn E. Hannigan and Roger A. Buchanan, 2007. Detection and measurement of semiconductor nanocrystals in aqueous solutions using DRC-ICP-MS. 28th Annual Meeting of the Society of Environmental Toxicology and. Nov, 2007. Milwaukee, WI.

Anil T Mangla, Robyn Hannigan and Roger Buchanan, 2007. The correlation of same-visit tests with laboratory-based measurements. 13th Annual Maternal and Child Health (MCH) Epidemiology Conference, Atlanta, GA Dec 2007

K. A. McKeon, B. L. Robinson, P.D. Williamson, S. F. Ali, R. A. Buchanan, 2007 SFN 2007 Significant changes in monoamine turnover rates in postnatal rat brains are associated with in-utero exposure to cigarette smoke. Poster at Society for Neuroscience, Nov 2007

Bouldin, J. L., Ingle, T.M., Cox, L.O., Buchanan, R.A., Hannigan, R.E. 2007.Toxicological Effects of Nanoparticles as Measured with Standard Laboratory Biomonitoring. Society of Environmental Toxicology and Chemistry. Nov, 2007. Milwaukee, WI.

K Mckeon, E Weiss, K Nicholson, P Williamson, S Ali and R Buchanan, 2007. Changes in regional brain concentrations and turnover rates of dopamine, serotonin and their metabolites associated with maternal exposure to cigarette smoke in rats. Proceedings of the 6th Annual Conference of the Internationals Society for the Prevention of Tobacco induced Diseases 6:51.

JL Bouldin, TM Ingle, LO Cox, RA Buchanan and RE Hannigan, 2007. Use of standard laboratory biomonitoring to measure toxicological effects of nanoparticles. Poster at North American Benthological Society. Columbia, SC

Ingle T, Hannigan R, Buchanan R and J Bouldin, 2007. Detection, Measurement and Toxicology of Semiconductor Nanocrystals in Ceriodaphnia dubia. Poster at NSTI Nanotechnology 2007.

JL Bouldin, T Ingle, L Cox, JM Stirrat, R Buchanan, RE Hannigan, 2006. Toxicological effects of nanoparticles as measured with standard laboratory biomonitoring. Poster at the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry, Montreal, Canada.

Garcia-Rill, E. and Buchanan, R, 2006. Smoking during pregnancy: Effects on arousal and attentional brain systems. Platform presentation at the 23rd NeuroToxicology Conference, Little Rock, AR.

KA McKeon, B Robinson, SF Ali, RA Buchanan, 2006. Changes in regional brain concentrations of dopamine, serotonin and their main metabolites associated with maternal exposure to cigarette smoke in rats. Platform presentation at Neuroscience 2006, Atlanta, GA.

M Patel, M.D. McLane, K.A. McKeon, M Hausman, R.D. Skinner, E. Garcia-Rill and R.A. Buchanan, 2006. Effects of in utero exposure to the constituents of cigarette smoke on the rat N40 and P13 evoked potentials during puberty. Poster at Neuroscience 2006, Atlanta, GA.

MD McLane, KA McKeon, M Hausman, RD Skinner, E. Garcia-Rill and RA Buchanan, 2006

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Effects of in utero exposure to the constituents of cigarette smoke on sensory gating during puberty. Platform presentation at the 12th Annual Meeting of the Society for Nicotine and Tobacco Research, Orlando, FL.

D. Clarke, RA Buchanan and R Hannigan, 2006. Headspace extraction GC-MS detection of drugs in serum. Platform presentation at Pittcon on Analytical Chemistry and Applied Spectroscopy, Orlando FL.

T Jackson, Pate M, K McKeon, RD Skinner, E Garcia-Rill, and R Buchanan, 2005. Effects of 17β-estradiol on P13 potential amplitude and habituation in ovariectomized rats. Poster at the 35th Annual Meeting of the Society for Neuroscience, Washington, DC.

Good, CH, KD Bay, RA Buchanan, KA McKeon, RD Skinner and E Garcia-Rill, 2005. Nicotine (NIC) exposure in utero affects postnatal firing properties in the pedunculopontine nucleus (PPN). Poster at the 35th Annual Meeting of the Society for Neuroscience, Washington, DC

McKeon K, R. Skinner, E Garcia-Rill, R Buchanan, 2005. Effects of cigarette smoke on P13 potential amplitude and habituation in rats. Poster at the 35th Annual Meeting of the Society for Neuroscience, Washington DC.

Ingle, T, N Enger-Luster, R Alexander, J Farris and R Buchanan, 2005. Nanoparticle absorption by the aquatic invertebrate, Ceriodaphnia dubia. Poster at the 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry Annual Meeting, Baltimore, MD.

Mamiya N, R Buchanan, T Wallace, RD Skinner and E Garcia-Rill, 2004. Novel site of action for nicotine: inhibition of pedunculopontine (PPN) output, blockade by mecamylamine. Poster ta the Associated Professional Sleep Societies, Philadelphia, PA.

Pate M, T Jackson, RD Skinner, E Garcia-Rill and R Buchanan, 2004. Changes in P13 amplitude and habituation during the reproductive cycle of female rats. Poster at the 34th Annual Meeting of the Society for Neuroscience, San Diego CA

Mamiya N, R Buchanan, RD Skinner and E Garcia-Rill, 2004. Inhibition of pedunculopontine (PPN) output by 1, 1-dimethyl-4-phenylpiperazinium iodide (DMPP) in the rat. Poster at the 34th Annual Meeting of the Society for Neuroscience, San Diego CA

K McKeon, N Mamiya, RD Skinner, E Garcia-Rill and R Buchanan, 2004. Novel Site of Action for Nicotine. Poster at the 11th Annual Meeting of the Society for Research on Nicotine and Tobacco. Scottsdale, AZ.

Mamiya, N, R Buchanan, R Skinner and E Garcia-Rill, 2003. “Novel Site of Action for Nicotine: Inhibition of Cholinergic Pedunculopontine (PPN) Output”, New Orleans, LA, Nov, 2003.

Beach P, Jamell, S and R Buchanan, 2000. Effects of MK-801 on the Limb Use Patterns of Swimming Young Rats. Poster at the 30th Annual Meeting of the Society for Neuroscience, November.

Phillips, C and R Buchanan, 1997. Simulated Microgravity Exposure-induced Changes in Limb Movement Patterns of Swimming Adult Rats. Poster at the 38th Annual Meeting of FASEB, New Orleans, LA.

Presentations at Regional and State Meetings Taylor Ingle, Enkeleda Dervishi, Kenton Leigh, Alexandru S. Biris, and Roger Buchanan, 2009.

Detection and Bio-Distribution of Inhaled Carbon Nanotubes in Lungs by Raman Spectroscopy. Nanotechnology for Healthcare Conference. Petit Jean, AR

Anindita Sengupta, Jennifer L. Bouldin, Taylor M. Ingle, and Roger A. Buchanan, 2008. "Uptake and distribution of Quantum Dots in Artemia franciscana and Pimephales promelas and a

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comparative study of dietary vs aqueous uptake in Pimephales promelas." Proceedings of the 3rd BioNanoTox and Applications Research Conference, Little Rock, AR, October 2008.

Bouldin, J.L., Ingle, T.M., SenGupta, A., Alexander, R., Hannigan, R.E., Buchanan, R.A, 2008. Food Chain Transfer and Aqueous Toxicity of Quantum Dots. MidSouth Society of Environmental Toxicology & Chemistry annual meeting. Vicksburg, MS. 14-16 May 2008.

Bouldin, J.L., Ingle, T.M., SenGupta, A., Alexander, R., Hannigan, R.E., Buchanan, R.A,. 2008. Aqueous toxicity and food chain transfer of quantum dots™ in freshwater algae and Ceriodaphnia dubia. 3rd Annual BioNanoTox Conference. Little Rock, AR. 23-24 October 2008.

S. Gera, M Horton, R Buchanan and R Hannigan, 2008. Trace element chemistry of human teeth. Poster at the 4th Annual Meeting of the Arkansas BioSciences Institute. Little Rock, AR Oct 7, 2008.

M Milanova, R Buchanan, S Haran, G Boratyn and T Smolenski, 2007. “Multi-objective evolutionary algorithms to decomposition and analysis of cortical evoked potentials”. Platform presentation at ARBIOS 2007. Jonesboro, AR.

Roger Buchanan, Mariofanna Milanova, Tomasz G Smolinski, Grzegorz Boratyn and Astrid A Prinz, 2006. Decomposition and Analysis of Cortical Evoked Potentials using ICA. Proceedings of the MidSouth Computational Biology and Bioinformatics Society.

Bouldin, J. Ingle TM, Cox LO, Buchanan R and R Hannigan 2007. Use of Standard Laboratory Biomonitoring to Measure Toxicological effects of nanoparticles”. Annual Meeting of the MidSouth Society of Environmental Toxicology and Chemistry. May 2007

Burton B, Parker A, Ingle T, Hannigan R and R Buchanan, 2007. Use of ICP-MS to measure cadmium from semiconductor nanocrystal in arerosol-exposed mice. INBRE Summer Research Seminar, Little Rock, AR, July 2007

Trammel K, Williamson P and R Buchanan, 2007. Characterizing the effects of a novel mercury chelator. INBRE Summer Research Seminar, Little Rock, AR, July 2007

Blackwood KC, Williamson P, Carey A, Hobbs, J, Hannigan R and R Buchanan, 2007. Effects of a novel mercury chelator on mercury excretion and distribution: A preliminary report. INBRE Summer Research Seminar, Little Rock, AR, July 20

McKeon AR SFN

AWARDED RESEARCH GRANTS (Since 1996)

Year Extramural (PI) Extramural (CO-I) Intramural (PI) Program Dev 2009 $3,187,395 2008 $2,494,824 $41,000 $27,954 2007 $327,163 $22,000 $33,100 2006 $141,197 $11,200 $1,000 2005 $139,328 $27,592 $10,790 2004 $142,747 $75,800 2003 $36,295 $8,900 $344,505 $45,000 2002 $42,054 $108,000 $200,000 2000 $4,950 $15,000 $95,113 1999 $7,800 $15,000 1998 $2,500 $2,220 1997 $3,325 $15,000 $3,650 1996 $12,417 $15,000

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Total $6.532,995 $218,900 $544,371 $354,553 Pending (Submitted during 2008) Buchanan, Roger PI, “Standoff Hazardous Agent Detection and Evaluation System” DOD PI R Buchanan, Co-PIs C Miller and M Dolan “Nanotechnology in Grades 7 – 12 Classrooms” SMET

proposal Arkansas Science & Technology Authority, STEM Professional Development Program. Funded during 2009 PI R Buchanan, Co-PIs C Miller and M Dolan “Biotech in A Box” Arkansas Department of Higher

Education Grant Competition - FY2009 No Child Left Behind: Improving Teacher Quality: P-16 Education Partnerships $105,128

PIs R Buchanan, M Srivatsan and A Lorence, INBRE equipment “INBRE Equipment Proposal qRT-PCR

and Electrophysiology” NIH, AR INBRE $65,362

Submitted and Funded during 2008: PI R Buchanan, Co-PI A Hayar. “Novel treatment for smoking dependence and relapse”. AR ABI

Collaborative Project Grant $74,500 PI S Blossom, R Buchanan and M Dolan. ”Maternal smoking and neuroimmune modulation involving

altered expression of nicotine sensitive acetylcholine receptors in the developing brain and immune system”. AR ABI Collaborative Project Grant $60,000

Buchanan, Roger PI, ABI summer student research fellowships. ASU ABI $13,400 Buchanan, Roger PI A Biris, Alex, Dolan, Maureen and Medrano, Giuliana Co-PIs. “Characterization of

Absorption and Clearance of Inhaled Carbon Nanotubes Arkansas BioSciences Institute Seed Grant $9,200

Buchanan, Roger PI, Boulden, Jennifer CoI “Supplement to URM RISE-UP to fund Minority High School Student Research Fellows”. NSF DBI 01731603 (Supplement) $12,450

Active 2008 (previously awarded): Effects of Nicotine on Processes Mediated by the Reticular Activating System” (through 4/30/09) L Cornett,

PI; R Buchanan, PL NIH through the IDeA Networks of Biomedical Research (NIH-INBRE), NCRR 1P20-RR022058 $129.450

Buchanan, Roger PI A Biris, Alex, Dolan, Maureen and Medrano, Giuliana Co-PIs. “Characterization of Absorption and Clearance of Inhaled Carbon Nanotubes ASU Arkansas BioSciences Institute Seed Grant $9,200

Buchanan, Roger PI, Standoff Hazardous Agent Detection and Evaluation System” DOD $2,000,000 Buchanan, Roger PI, 2008 Research Support for International Graduate Students. ASU $1,600 Buchanan, Roger PI Upgrade for HPLC. ASU OORTT $5,300 Buchanan, Roger, Lorence Argelia, Srivatsan, Malathi PIs “Acquisition of New Equipment for Shared

Facilities”. AR INBRE $24,518 Buchanan, Roger PI. “ABSORPTION, ACCUMULATION AND EXCRETION OF NANOPARTICLES BY LIVING

ANIMALS” UALR Nanotechnology Center. $23,600 Buchanan, Roger PI , R Hannigan, Co-PI..NSF URM NSF DBI 01731603 “URM: Cross disciplinary

research at the interface of biotechnology and the environment. $194,734 Written, and submitted during 2008 but not funded Buchanan, Roger PI, Clarke, David and Hannigan, Robyn CoIs “Development of a Fluorescence GC

Detector for High Throughput, Automated Speciation of Mercury Containing Compounds”. CETAC, Inc

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PI R Buchanan, Co-PIs A Biris and V Zharov. “Delivery by Inhalation and Bio-Distribution of Carbon Nanostructural Materials”.

Dowling, Carolyn, PI, Buchanan, Roger CoI “Supplement to REU RISE to fund Minority High School Student Research Fellow”.

Active 2007: NSF URM NSF DBI 01731603 “URM: Cross disciplinary research at the interface of biotechnology and the

environment. R Buchanan, PI (Project Director), R Hannigan, Co-PI. $309,863 2007-6 ABI equipment grant $10,800 2007-5 (through 6-30-070 ABI Undergraduate $19,720 2007-4 (through 8/31/070 Honors Summer Undergraduate Research Internship in Biotechnology $ 5,000 2007-3 (through 5/31/08) RAHSS $12,000 2007-2 (through 06/30/08) “Effects of In Utero Exposure to a Novel Chelator” R Buchanan, PI

Affinity Labeling Technologies $17,688 2007-1 (through 03/31/08) “Effects Of Novel Chelator On Mercury Fate And Distribution” R Buchanan, PI,

Affinity Labeling Technologies $40,230 Written, and submitted during 2007 but not funded Hannigan, Robyn and Buchanan, Roger PIs “Rapid Onsite Detection and Identification of Illicit Drugs and

Associated Components” Dept of Justice $1,3000,000 (Submitted Oct 2007) Bouldin, Jennifer, PI, Buchanan, Roger Co-PI, Hannigan, Robyn, Co-PI. “Environmental Fate and Effect of

Miscible Nanoparticles in Aqueous and Mammalian Models“ EPA Mariofana Milanova, PI, Buchanan, Roger, Co-I “Neurodynamics and Brain Studies Laboratory in

Arkansas” NSF NSF MRI “MRI: Acquisition of a Laser Ablation ICP-MS” R Buchanan, PI NIH STTR “Rapid detection of smoked residues in biological fluids” Hyphenated Solutions. R Hannigan and

R Buchanan, PIs Funded: 2008-10 PI R Buchanan, Co-PI A Hayar. “Novel treatment for smoking dependence and relapse”. AR ABI

Collaborative Project Grant $74,500 2008-9 PIs S Blossom, R Buchanan and M Dolan. ”Maternal smoking and neuroimmune modulation

involving altered expression of nicotine sensitive acetylcholine receptors in the developing brain and immune system”. AR ABI Collaborative Project Grant $60,000

2008-8 Buchanan, Roger PI, ABI summer student research fellowships. ASU ABI $13,400 2008-7 Buchanan, Roger PI, Boulden, Jennifer CoI “Supplement to URM RISE-UP to fund Minority High

School Student Research Fellows”. NSF DBI 01731603 (Supplement) $12,450 2008-6 Buchanan, Roger PI A Biris, Alex, Dolan, Maureen and Medrano, Giuliana Co-PIs. “Characterization

of Absorption and Clearance of Inhaled Carbon Nanotubes ASU Arkansas BioSciences Institute Seed Grant $9,200

2008-5 Buchanan, Roger PI, Standoff Hazardous Agent Detection and Evaluation System” DOD $2,000,000 2008-4 Buchanan, Roger PI, 2008 Research Support for International Graduate Students. ASU $1,600 2008-3 Buchanan, Roger PI Upgrade for HPLC. ASU OORTT $5,300 2008-2 Buchanan, Roger, Lorence Argelia, Srivatsan, Malathi PIs “Acquisition of New Equipment for

Shared Facilities”. AR INBRE $24,518 2008-1 Buchanan, Roger PI. “ABSORPTION, ACCUMULATION AND EXCRETION OF NANOPARTICLES BY

LIVING ANIMALS” UALR Nanotechnology Center. $23,600

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2007-7 (through Sept 30, 2010) NSF URM NSF DBI 01731603 “URM: Cross disciplinary research at the interface of biotechnology and the environment. R Buchanan, PI (Project Director), R Hannigan, Co-PI. $309,863

2007-6 ABI equipment grant $10,800 2007-5 (through 6-30-070 ABI Undergraduate $19,720 2007-4 (through 8/31/070 Honors Summer Undergraduate Research Internship in Biotechnology $ 5,000 2007-3 (through 5/31/08) RAHSS $12,000 2007-2 (through 06/30/08) “Effects of In Utero Exposure to a Novel Chelator” R Buchanan, PI

Affinity Labeling Technologies $17,688 2007-1 “Effects Of Novel Chelator On Mercury Fate And Distribution” R Buchanan, PI

Affinity Labeling Technologies $40,230 2006-1. “Effects of Methamphetamine Challenge on Regional Neurotransmitter Distribution in Rat Pups

Exposed to the Constituents of Cigarette Smoke In Utero” R Buchanan PI ASU OORTT Undergraduate Minority Research grant for Tamika Keener $1,000

2005-1. “Effects of exposing pregnant rats to cigarette smoke on the behavior and brain neurotransmitter concentrations of their offspring” R. Buchanan PI

ASU ABI $27,922 2005-2. “Effects of in utero exposure to the constituents of cigarette smoke on sensory gating during

puberty” AR SILO/Undergrad Res Fellowship (AR SILO/SURF) for Melissa McClane $1,631 2004-1. “Localization of nicotine-sensitive cells in the brain stem”

AR SILO/SURF (with Akash Shah, ASU undergraduate) $3,750 2004-2. “Water quality sampling, analysis and annual load determination for TSS, nitrogen and phosphorus

at the L’Anguille River near Palestine, AR” J Farris and R Buchanan PIs AR Soil and Water Cons Comm (through the Arkansas Water Resources Center) $68,000 2004-3. “Effects of environmental tobacco smoke on reticular activating system–mediated processes

underlying arousal and attention in rats” R Hannigan PI, R Buchanan Co-I NSF RAHMMS $7,800 2004-4. “Effects of nicotine on arousal: continuous exposure and tobacco smoke” R Buchanan PI ABI $152,528 2004-5. (Through 04/30/09) “Effects of Nicotine on Processes Mediated by the Reticular Activating System”

(through 4/30/09) L Cornett, PI; R Buchanan, PL, NIH through the IDeA Networks of Biomedical Research (NIH-INBRE)

NCRR 1P20-RR022058 Project total $693,485 2003-1. “Common mechanisms in arousal and movement: The role of pedunculopontine stimulation-induced

prolonged responses.” R. Buchanan, PI NIH through the Arkansas Biomedical Research Infrastructure Network (NIH BRIN) $24,900 2003-2. “Arousal and sensory gating: Effects of acute and chronic exposures to nicotine” R Buchanan, PI

Arkansas Biosciences Institute $178,156 2003-3. Equipment Grant R Buchanan, PI Arkansas Biosciences Institute $169,349 2003-4. “Arousal and sensory gating: Single unit recordings from PPN neurons in awake rats” R Buchanan,

PI NIH BRIN $11,395 2003-5. “Effects of Effects of Agricultural Chemicals on Animal Behavior” R Hannigan, PI, R

Buchanan CoI NSF RAHMMS $8,900 2002-1. “Investigation of Cellular Mechanisms Underlying the P13 Evoked Potential of Rats” R Buchanan,

PI Arkansas State University $4,000

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2002-2. “Common Mechanisms in Arousal and Movement: The Role of PPN Stimulation-Induced PRs” R Buchanan, PI NIH BRIN Faculty Research Award $22,000

2002-3. “Common Mechanisms in Arousal and Movement: The Role of PPN Stimulation-Induced PRs” R Buchanan, PI NIH AR BRIN Laboratory Equipment Award $24,759

2002-4. “Effects of Nicotine on Auditory Evoked Potentials in Rats” AR SILO/SURF for V Zachary $3,900 2002-5. “Effects of Nicotine on Arousal and Sensory Gating” R. Buchanan, PI Arkansas Biosciences Institute $104,000 2002-6. “Arousal and Sensory Gating: Single Unit Recordings from PPN Neurons in Awake Rats” R

Buchanan, PI NIH BRIN $11,395 2000-1. “Physiologic Response to Simulated Microgravity: Locomotor Responses” R Buchanan, PI NASA, Arkansas Space Grant Consortium (NASA ASGC) $4,950 1999-1. "Physiologic Response to Simulated Microgravity Phase 2” (Through 12/31/2000), M. Soulsby PI, R

Buchanan, CoI NASA ASGC . Project total $30,000, Annual budget 15,000 1999-2. “Physiologic Response to Simulated Microgravity: Locomotor Responses R Buchanan, PI NASA ASGC $7,800 1998-1. “Effects of an NMDA Receptor Antagonist on Behavioral Development in Young Rats”. ASU Faculty Research Grant, $2,220 1998-2. “Changes in Patterned Limb Movements: Transition from Juvenile to Adult Patterns”, AR SILO/SURF for Shalla Lindley $2,500 1997-1. “Effects of Prenatal Alcohol Exposure on the Development of Locomotor Behaviors in Young Rats”

AR SILO/SURF for Valerie Turnbow. $3,325 1997-2. “Software for use in Animal Physiology and Human Anatomy and Physiology courses”. ASU University Academic Computing Software Grant, 1997. $3,650 1996-1. "Physiological Adaptations to Weightlessness" Phase 1, J. Pasley, PI R Buchanan, CoI NASA ASGC (Through 12/32/1997) Project total $30,000, Annual budget $15,000 1996-2. "Effects of Hypergravity-induced Increases in CNS Thyroxin Releasing Hormone (TRH) on

Cerebellar Development and Locomotor Skill Acquisition by Young Rats" R Buchanan, PI NASA ASGC $9,414 1996-3. "CNS Responses to Altered Gravity Environments: Effects of Increased TRH Levels on Locomotor

Behavior Development" R Buchanan, PI. NASA ASGC $1,224 1996-4. "Responses of the CNS to Altered Gravity Environments: Analysis of Swimming Skill Acquisition

by Young Rats” R Buchanan, PI. NASA ASGC $2,379 Awarded Program Improvement Grants 2005 “Upgrade Access Grid Conference Center” R Buchanan PI NIH through the IDeA Networks of Biomedical Research (NIH-INBRE) $10,790 2003 “Access grid classroom” R Buchanan, PI NIH BRIN $45,000 2002 New Faculty Recruitment Award

NIH BRIN $200,000 2000 “Implementing Problem Based Learning in the Introductory Biology Laboratory” National Science Foundation (NSF) $95,113 1997 “Software for use in Animal Physiology and Human Anatomy and Physiology courses” ASU University Academic Computing Software Grant, 1997. $3,650

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PHD DISSERTATION COMMITTEES Chair (In progress) Katherine A McKeon (Projected graduation date, May 2008) Taylor Ingle (Projected graduation date May 2010) Kenton Leigh Member (In progress) David Clarke (Projected graduation date May 2009) Alejandra Ratti (Projected graduation date May 2009) Walter Acosta Seth Schirmer Member (Completed) Mai Elobied Jonathon Maul Malcolm McCallum William Stephens MASTER’S THESIS COMMITTEES

Chair (Completed) Jeremy Jackson (“Effects of wildlife stand improvements and prescribed burning on bat

and insect communities; Buffalo River Range District Ozark-St Francis National Forest, Arkansas”)

Drew Reed (“Roosting Ecology of the Southeastern Myotis (Myotis austroriparius) in Southwest Arkansas with Emphasis on the U.S. Army Corps of Engineers’ Lake Greeson Project Area”)

Lann Wilf (“The species composition and habitat use of bat populations in Delta National Forest”)

Will Williams (“A morphological comparison of spermatozoa representing two different populations of Hyla cinerea”)

David Swindle (“"Morphological Characterization of Testicular Spermatozoa of Selected Rana Species (Amphibia, Anura, Ranidae) Using Fluorescence Microscopy").

Chair (In progress) Tammy Jones (“Natural History Aspects of the Southeastern Bat (Myotis austroriparius) in

Southwestern Arkansas”)

Member (Completed) Sonya Baker Nova Goosby

Larissa Clark Sarah Clem Wat Hardin Ranjini Murthy (MS Chemistry) Jerry Leech Christy Milam Sherrie Oleson-Ming Thomas J Robinson Lynn Heard (MS Chemistry)

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UNDERGRADUATE HONORS THESES COMMITTEES

Member (in Progress) Sarah Holland Chair (Completed) Pamela Beach (“Physiologic Response to Simulated Microgravity—Muscular Function”) Akash Shah, (“Localization of nicotine-sensitive cells in the brain stem”) Victoria Zachary, (“Effects of Continuous Exposure to Nicotine on the P13 MAEP in Rats”) Hemabh Mishra (“Effects of Prenatal Exposure to Cigarette Smoke on the Development of

Pedunculopontine Nucleus in the Rat”) Josh Mosley (“The Effects of Prenatal Tobacco Smoke Exposure on the Postnatal Development

of Hippocampal Pyramidal Neurons”) Member (Completed) Michelle Mary Melissa McDade Clay Riley Sam Snipes Brent Stewart

. SELECTED UNIVERSITY COMMITTEES

Present Molecular BioSciences Program Committee Information Technology Services Advisory Committee Technology Appropriation Committee Athletic Committee Institutional Animal Care and Use Committee (Chair since 1996) Graduate School Program Committee Past Faculty Research Committee General Education Task Force Program Committee for the Arkansas Soil and Water Education Conference ABI Director Search Committee Biosciences Research Building (ABI) Planning Committee Arkansas BioSciences Animal Facility Director Search Committee

SELECTED DEPARTMENT AND COLLEGE COMMITTEES Present Selection committee for Honors Summer Research Fellowships in Biotechnology (Chair) Biology Graduate Program Committee (Chair) Department of Biological Sciences Promotion, Tenure and Retention Committee Biology Scholarship Committee Environmental Sciences Program Committee Past Biology Strategic Planning Committee (Chair) Department Curriculum Committee

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Infrastructure Fund Committee (Chair) AR Department of Higher Education Biology Department Self-Study Committee (Chair) Department of Biological Sciences Chair Search Committee (Chair) 2002 Department of Biological Sciences Cell Biologist Search Committee (Chair) Department of Biological Sciences INBRE Faculty Search Committee Department of Chemistry and Physics Chair Search Committee Dean’s Advisory and Planning Committee Computing Advisory Committee Pre-professional committee ABI tour Marion HS 2/27/08 22 students; 2 hrs Director of Environmental Sciences Director Search Committee (Chair)

SELECTED SERVICE TO REGION & STATE 2000-Present Arkansas Biomedical Research Initiative Network Steering Committee (AR

INBRE). Oversees the distribution of over $8,000,000 in NIH funding to Arkansas colleges and universities

1999-Present Member, Arkansas Watershed Advisory Group. Provides assistance and expertise to individuals and watershed groups seeking assistance in ensuring the water quality of Arkansas’ streams, lakes and rivers.

2000-Present Member, Arkansas Department of Soil and Water Conservation Commission NonPoint Source Pollution Support Group.

2004 STRIVE program sponsor 1999-2005 Technical Advisor to the L’Anguille River Watershed Project (Cross, Crittenden

and Phillips counties, AR). PROFESSIONAL MEMBERSHIPS Adjunct Professor, Department of Anatomy, University of Arkansas for Medical Sciences Arkansas Chapter of the Society for Neuroscience Arkansas Academy of Science Society for Neuroscience Visiting Scientist, National Institutes of Health, Laboratory of Neurobiology, Bethesda, MD.

Undergraduate Student Researchers who have worked in my lab

Student Area of study Institution Cristy Phillips†† 1995-1997 (BS Biology, MS Physical Therapy,

completed)

1995-1997 (BS Biology, MD, UAMS, completed)

Arkansas State University

Valerie Turnbow Rebecca Smith 1995-1996 (BS Psychology)Shalla Lindley 1997-1998 (BS Biology)Stasia Jammell 1997-1998 (BS Biology)Sara Adams 1999-2000 Florida State UnivPamela Beach 1999-2000 (BS Biology)Michelle Pate³, º.†† 2003-2005 (BS Biology, UT Memphis Dental

School)

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Student Area of study Institution Victoria Zachary 2003-2005 (BS Biology. U Mo Vet School)Tracy Jacksonº, †† 2004-2006 (BS Biology, MS, U North Carolina)Megan Hausman†,º, †† 2003-2006 (BS Biology, MS Physical Therapy)Akash Shah1,²,†† 2003-2006 (BS Biology), PhD George

Washington University

Taylor Ingle**, º 2005-present (BS Chemistry, PhD MBS) Arkansas State University Danielle Smith** 2005 (BS Chemistry)Leslie Knod†† 2006 (BS Biology, MD UAMS)Allison Smith†† 2004-2006 (BS Biology, MS ASU Biology)Joshua Mosley² 2004-2006t (BS Biology)Nekia Shewmaker 2005-2006 Arkansas State UniversityMelissa McLane**,¹,†,º 2004-2006 (BS Biology, MD Mercer Univ, GA)Kelly Moran 2002-2003 (Pharm, UAMS)Kelli VanHouten 2004-2005 (BS Biology)Madhvi Patelº,†† 2005-2007 (BS Biology) Arkansas State UniversityKelly Smith 2005-2007 Arkansas State UniversityPaula Williamson 2006-2007 Arkansas State UniversityJessica Stirrat* 2006 Worcester Polytech Inst.Brandi Cooksey** 2006 Arkansas State UniversityHemabh Mishra² 2004-2006 (BS Biology, Podiatry)Shannon Cook** 2006 Arkansas State UniversityTamika Keener** 2006 Arkansas State UniversityRegina Alexander**,º 2005-Present Arkansas State UniversityBridgette Harris* 2005, BS Biology Univ. AR at Pine BluffMichael Balfour* 2004 Morgan State UniversityBrielan Smeichowski 2006-Present Arkansas State UniversityScott Gairhan 2007, (BS Biology) Arkansas State UniversityAmanda Polston** 2006-2007, (BS Psychology, MS Psychology) Arkansas State UniversityAlbert (EJ) Carey** 2007 Arkansas State UniversityAnthony Parker* 2007t Brittany Burton 2007 (UT Memphis Dental School) Arkansas State UniversityEmily Weiss 2006-Present Texas A&M UniversityKelly Nicholson 2006-Present Arkansas State University

Kenton Leigh 2008 Arkansas State University

Sarah Holland 2008 Arkansas State University

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Student Area of study Institution Benjamin Radin 2008 Virginia Tech University

High School StudentsKiandra Trammell 2007-Presemt Nettleton HS Saria Santos 2004 Roosevelt HS, Chicago, ILSarah VanWinkle 2005 Nettleton HS Kara Taylor 2055 Jonesboro HSKeith Trammell 2006 Nettleton HS Nick Reed 2006 Nettleton HS KC Blackwood 2007-Present Jonesboro HSJose Hobbs 2007 RayMor HS, MOPreston Scrape 2007-Present Jonesboro, HSTJ Eskridge 2008 Nettleton HS William Ryan 2008 Jonesboro HSStacey Lewis 2004 Jonesboro, HS

* Minority participant in NSF REU ** Ronald McNair Minority Achievement Program Fellow ¹ SILO/Student Undergraduate Research Fellowship Award winner ² Honors student, sponsor of Honors thesis research ³ Winner, Faculty for Undergraduate Neuroscience Travel Award to the Society for Neuroscience Annual meeting º Poster Presenter at International meeting † Poster presenter at State/Regional meeting †† Presently pursuing post-baccalaureate degree Bold denotes students who are members of under-represented minorities.

Peer Reviewed Papers (Before 1996) Mink, LA and RA Buchanan, 1995. An Effective, Reliable, Inexpensive Cryofixation Device.

Proceedings of the Arkansas Academy of Science. S.E. Trauth, Ed. 48:257-258. Andrews, SB, RA Buchanan, and RD Leapman, 1994. Quantitative Dark-Field Mass Analysis of

Ultrathin Cryosections in the Field Emission STEM. Scanning Microscopy International. 8:13-24. 8 citations

Buchanan RA, RD Leapman, M. O'Connell, TS Reese, and SB Andrews, 1993. Quantitative Scanning Transmission Electron Microscopy of Ultrathin Cryosections: Subcellular Organelles in Rapidly Frozen Liver and Cerebellar Cortex Journal of Structural Biology 110(3):244-255. 22 citations. IF 3.5

Leapman, RD, JA Hunt, RA Buchanan and SB Andrews, 1993. Measurement of Low Calcium Concentrations in Cryosectioned Cells by Parallel-EELS Mapping. Ultramicroscopy. 49:225-234. 24 citations IF 1.9

Buchanan, RA and RC Wagner, 1990. Morphometric changes in pericyte-capillary endothelial cell associations, correlated with vasoactive stimulus. Microcirculation, Endothelium and Lymphatics. 6:159-181. 14 citations IF 2.8

Buchanan, RA and RC Wagner. Associations between Pericytes and Capillary Endothelial Cells in the Eel Rete Mirabile, 1990. Microvascular Research. 36:60-76. 3 citations IF 1.9

Wagner, RC, RA Buchanan, and R Froehlich, 1988. Preparations of Isolated Blood Capillaries. Scanning Microscope 2(4):2109-2116.

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Froehlich, R, RA Buchanan and RC Wagner, 1988. Isolation and Separation of Fenestrated and Continuous Capillary Endothelium by Using Magnetic Beads. Microvascular Research. 35:242-245. IF 1.9

Buchanan, RA, RC Wagner, SB Andrews, J Frǿkjær-Jensen, 1988. Effect of Section Thickness on the Morphological Characterization of the Vesicular System. Microvascular Research. 35:191-196. 4 citations IF 1.9

Conference Proceedings and Book Chapters (Before 1996) Buchanan, RA, 1994. Quantitative Scanning Transmission Electron Microscopy in Neurobiology:

Measurements of Synaptic Activity-induced Intracellular Calcium Redistributions. Proceedings Segundo Congreso Mexicano de Microscopia Electronica., pg 56.

Andrews, SB, RA Buchanan, and RD Leapman, 1993. Quantitative STEM of Ultrathin Cryosections: High Resolution Elemental and Water Measurements. (Invited review presented at the 1993 Pfefferkorn Conference, Cambridge, UK.)

Leapman, RD, SQ Sun, SL Shi, RA Buchanan and SB Andrews, 1993. STEM measurement of subcellular water distributions. In: Proceedings of the 51st Annual Meeting of the Microscopy Society of America. G.W. Bailey, & C.R. Reider, Eds. San Francisco Press, San Francisco. pp 568-569.

Andrews SB, RA Buchanan and RD Leapman, 1993. Characterization of Cryosections in the FE-STEM: Specimen Damage during Freeze-drying and Analysis. Microbeam Analysis 2:S250-251.

Andrews SB, RA Buchanan, RD Leapman, 1993. Characterization of Calcium-release Organelles in Purkinje Cells by Combined X-ray and Mass Analysis. Microbeam Analysis 2:S210-211.

Leapman, RD, JA Hunt, RA Buchanan and SB Andrews. Parallel-EELS Mapping of Calcium in Cryosectioned Cells, 1992. In: Proceedings of the 50th Annual Meeting of the Electron Microscopy Society of America. G.W. Bailey, J. Bentley & J.A. Small, Eds. San Francisco Press, San Francisco. pp 1566-1567.

Andrews, SB, RA Buchanan, MF O'Connell and RD Leapman, 1992. Quantitative Mass Analysis of Cryosections in the Field Emission STEM. In: Proceedings of the 50th Annual Meeting of the Electron Microscopy Society of America. G.W. Bailey, J. Bentley & J.A. Small, Eds. San Francisco Press, San Francisco. pp 1574-1575.

Leapman, RD, JA Hunt, RA Buchanan and SB Andrews, 1992. Quantitative Dark-field and EELS Mapping of Biological Cryosections. 32nd Annual Meeting of the Societe Francaise de Microscopie Electronique, Rouen-Mont St. Aignan, July 3, pp. 7-8. (Invited Symposium)

Wagner, RC and RA Buchanan. Microvascular Pericytes in the Eel Retia Mirabile, 1992. In: Microvascular Pericytes in Ocular Microcirculation. R.N. Weinreb and W.L. Joiner, Eds. Elsevier Science Publishers B.V. pp 49-57.

Presentations to learned forums Before 1996 "Techniques for Analysis of Alterations in the Locomotor Behaviors Associated with Exposure to

Altered Gravity Environments". 3rd Annual Arkansas Space Grant Symposium, April 1995. "An Effective, Reliable, Inexpensive Cryofixation Device" with LA Mink. Arkansas Academy of

Science. April, 1994. "Effects of Altered Gravity Environments on Rat Locomotor Behaviors". 2nd Annual Arkansas

Space Grant Symposium. April, 1994. "Quantitative Scanning Transmission Electron Microscopy in Neurobiology: Measurements of

Synaptic Activity-induced Intracellular Calcium Redistributions." Invited symposium at the II Congreso Mexicano de Microscopa Electronica, in Cancun Mexico, September, 1994.

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"Water Content of Cells in Intact Brain Tissue" with C Chamberlain. SILO/SURF Undergraduate Research Conference. October, 1994.

"Drug Testing: Developing Systems for Determining the Effects of Substances used to Treat Brain Injuries". Presentation to the Arkansas State University Technology Transfer Conference. April, 1993.

“Actin stinaing patters of pericuytes and endothelial cells in the rete mittaboli of the eel. Buchanan R and Wagner RC, 1988. J Cell Biol 107:581a

Buchanan r, wagner, R,m andres SB and Froekjaer_JensenJ, 1987. Effect or section thichness on morphometric estimation of vesicle desnity in rapidly-frozen and prefixed capillaries. Federatino Proceddings, 46:1634.

Buchanan R, Froehlich R and Wagner RC, 1987. Purificatin of franctinosof fenestrated and conintuous capillariy endothelium for the rete mirabile. J Cell Biol 105:329.

Buchanan R and Wagner RC, 1990. Epinephrine and histamine induced changes in the capillary bedo f the eel rete mirabile are correclate with alterains in periciyte morphology. Fed Proc. 50:2308.

Shepard J, Fosnacht B, Buchanan R, Chen S and Wagner R, 1990. Primary culture of pericytes and endothelial cells derived from the eel rete mirablile. J Cell Biol 111:1851.

Awarded Research Grants (Before 1996) 1990-92 "Ion Fluxes During Synaptic Activity and Long-term Potentiation in the Hippocampus" National Institutes of Health IRTA Fellowship $78,500 1992 "Pericyte Function in the Eel Rete Mirabile" Marine Biological Laboratory, Woods Hole, MA $15,400 1993 "Relationships Between Neuronal and Astrocytic Calcium Activity in the Intact Brain" Arkansas State University Faculty Research Grant $8,900 1993 "Coordinated Astrocytic and Neuronal Calcium Activity" Arkansas Science and Technology Authority $35,500 1993 "Cerebellar Function and Structure: Adaptation to Chronic Altered Gravity Environments" NASA, Arkansas Space Grant Consortium $4,400 1993 "Construction of Incubation Chambers for the Short-term Maintenance of Intact, Isolated Mammalian Cerebellar Hemispheres" Nathan Deutsch Faculty Research Award (Arkansas State University) $450 1994 "Water Content of Cells in Intact Brain Tissue" SILO Undergraduate Research Fellowship $3,802 1995 "Effects of Hyper-gravity on Development of Locomotor Behaviors in Young Rats" Arkansas Space Grant Consortium $11,517 1995 "Application of Techniques Used for Measuring Locomotor Responses to Hypergravity Environments: Swimming Skill Acquisition by Young Rats" NASA, Arkansas Space Grant Consortium $5,698 1995 "Physiological Adaptations to Weightlessness," with Drs. J. Pasley, M. Shock, N. Reese and G. Anderson. NASA, Arkansas Space Grant Consortium $15,000 1995 "Analytical Electron Microscopy Measurements of Synaptic Activity Dependent Changes in Calcium Concentrations within Dendritic Compartments of Hippocampal CA3 Neurons." Laboratory of Neurobiology, National Institutes of Health $4,800

Principal Investigator/Program Director:

PHS 398 (Rev. 04/06) Page _ Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME

Carole L. Cramer POSITION TITLE Professor Executive Director, Arkansas Biosciences Institute at Arkansas State University, Jonesboro

eRA COMMONS USER NAME

ccramer EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY

University of California, Berkeley BA 1974 Biological Sciences University of California, Irvine PhD 1982 Molec. Biology & Biochem. The Salk Institute, La Jolla, CA Postdoc 1982-86 Plant Molecular Biology

A. Positions and Honors: Positions & Employment. 1974-1976 Laboratory Assistant, Research Associate, Genetics, Univ. of California, Berkeley 1976-1981 Teaching Assistant, Biological Science, Univ. of California, Irvine 1981-1982 Research Assistant, Molecular Biology & Biochemistry, Univ. of California, Irvine 1982-1986 Postdoctoral Research Fellow, Plant Biology Lab, Salk Institute for Biological Studies, San Diego, California (with C. J. Lamb) 1986-1990 Assistant Professor, Plant Pathology and Physiology, Virginia Tech, Blacksburg, VA 1990-1997 Associate Professor, Plant Pathology and Physiology, Virginia Tech, Blacksburg, VA 1993-1998 Vice President for Research, Co-Founder, CropTech Development Corp., Blacksburg, VA 1997-2004 Professor, Plant Pathology and Physiology, Virginia Tech, Blacksburg, VA 1998-2002 Chief Scientific Officer, CropTech Corporation, Blacksburg, VA 2001-2004 Chief Scientific Officer, Co-founder, BioDefense Technologies Inc., Blacksburg, VA 2004-pres Executive Director, Arkansas Biosciences Institute, ASU, Jonesboro, AR 2004-pres Professor, Department of Biology and College of Agriculture, ASU, Jonesboro, AR 2007-pres Chief Scientific Officer, Co-founder, BioStrategies LC, Jonesboro, AR Awards, Honors and Recognition. 1977-1981 NIH Cellular and Molecular Biology Graduate Traineeship, Univ. of California, Irvine, CA 1983-1986 NSF Postdoctoral Fellow in Plant Biology, Salk Institute, San Diego, CA 1989 Henderson Award, Departmental Award for Outstanding Faculty Member 1988-1993 NIH FIRST (New Investigator) Award, Virginia Tech , Blacksburg, VA. 1998 U.S. Patents (2 awarded) for plant-based transgene expression system (Virginia Tech) 1999 U.S. Patent awarded for plant-based production of lysosomal enzymes (CropTech/VA Tech) 1999 WHO Temporary Consultant and speaker, Seminar on Biotechnology and its Impact on

Human Health, World Health Organization, Geneva, November 19-20, 1999. 2000 Invited speaker and panelist, FDA Public Hearing on Plant-Derived Biologics, Ames, Iowa. 2002 Invited speaker, participant, National Academy of Sciences Workshop on “Exploring Genetic

Modification of Plants: New Approaches and Implications”, August 15, 2002. 2002 Most Cited Authors, Institute for Scientific Information (ISI) 2003-07 Appointed, US Department of Agriculture’s Advisory Committee on Biotechnology and 21st

Century Agriculture (reappointed for 2004-2006 and 2006-2007 term). 2005, 07 Scientific Advisory Panel, International Conference on Plant-based Vaccines & Antibodies Federal Peer Review Panels. U.S. AID, Plant Path. Panel, 1990; NIH Biochemistry (ad hoc member), 1992; NIH AREA Grants, 1992; NSF SBIR Grants (Integrative Biology), 1995, 1997; NIH/NIAID BioDefense Partnership Grants (Vaccines, Adjuvants, Therapeutics Panel), 2002 and 2003; ad hoc (1 grant) reviewer for 2007, 2008 panels.

Principal Investigator/Program Director (Last, First, Middle): Cramer, Carole L.

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

B. Selected Peer-Reviewed Publications in the Area of Plant-based Bioproduction: 1. Cramer, C.L., Weissenborn, D.L., Oishi, K.K., Grabau, E.A., Bennett, S., Ponce, E., Grabowski, G.A. and

Radin, D.N. 1996. Bioproduction of human pharmaceutical enzymes in tobacco. In: Engineering Plants for Commercial Products and Application (G. Collins, R. Shepherd, eds.), Ann. N.Y. Acad. Sci. 792:62-71.

2. Cramer, C.L., Weissenborn, D.L., Oishi, K.K., and Radin, D. 1996. High-level production of enzymatically active human lysosomal proteins in transgenic plants. In: Transgenic Plants: A Production System for Industrial and Pharmaceutical Proteins, M. Owens & J. Pen, eds., John Wiley & Sons, Ltd., pp. 299-310.

3. Cramer, C.L., Boothe, J., and Oishi, K.K. 2000. Transgenic plants for therapeutic proteins: Linking upstream and downstream strategies. Curr. Top. Microbiol. Immunol., 240:95-118.

4. Medina-Bolivar, F. R. Wright, V. Funk, D. Sentz, L. Barroso, T.D. Wilkins, W. Petri, and C.L. Cramer. 2003. A non-toxic lectin for antigen delivery of plant-based mucosal vaccines. Vaccine 21:997-1005.

5. Houpt, E., L. Barroso, L. Lockhart, R. Wright, C. Cramer, D. Lyerly, and W. Petri, Jr. 2004. Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin. Vaccine 22:611-617.

6. Medina-Bolivar, F. and C.L. Cramer. 2004. Production of recombinant proteins in hairy roots cultured in plastic sleeve bioreactors. In: Recombinant Gene Expression: Reviews and Protocol, Method in Molecular Biology, Vol. 267, P. Balbas and A. Lorence, eds., Humana Press, pp. 351-364.

7. Zhang, C. F. Medina-Bolivar, S. Buswell, and C.L. Cramer. 2005. Purification and stabilization of Ricin B from tobacco hairy root culture medium by aqueous two-phase extraction. J. Biotechnol. 117:39-48.

8. Reed, D., L. Nopo-Olazabal, B. Woffenden, V. Funk, V, M. Reidy, M. Dolan, C. Cramer, and F. Medina-Bolivar. 2005. Expression of functional hexahistidine-tagged ricin B in tobacco. Plant Cell Rep. 24:15-24.

9. Cramer, C.L. 2007. Antigens and therapeutics – its all in the delivery, Internat. Conf. on Plant-Based Vaccines and Antibodies (PBVA 2007), Univ. of Verona, Italy, June 18-20 2007. (Invited symp. speaker)

10. Cramer, C.L., M.J. Reidy and M.C. Dolan. 2007. Methods of delivery of molecules to cells using ricin subunit and compositions relating to same, US Provisional Patent 60/944193; pending; full filing 2008.

11. Liu, J., M.C. Dolan, M. Reidy, and C.L. Cramer. 2008. Expression of bioactive single-chain murine IL-12 in transgenic plants. J. Interferon Cytokine Res., 28:27–38.

12. Medrano, G., M.J. Reidy, J. Liu, J. Ayala, M.C. Dolan and C.L. Cramer. 2009. Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants. In Methods in Biotechnology: Recombinant Proteins from Plants, L. Faye, V. Gomond, eds., Humana Press, USA, pp. 51-68.

13. Liu, C., M. Towler, G. Medrano, C. Cramer, P.J. Weathers. 2009. Production of mouse interleukin-12 is greater in tobacco hairy roots grown in a mist reactor than in an airlift reactor. Biotechnol. Bioeng.102:1074-1086.

C. Research Support and Grantsmanship. Cramer has had continuous research funding since 1988. As a faculty member at Virginia Tech, she generated in excess of $2M of competitive research funding as PI or co-PI from NIH (including NIH FIRST Award), NSF, USDA and USDA’s BARD programs. During her tenure as VP for Research or Chief Scientific Office of CropTech Corp., the company successfully competed for 5 Phase I SBIRs (NIH, DOD, NCI), 4 Phase II SBIRs and an Advanced Technology Program grant totaling more than $10M in research funding.

Current Research Support NAME

AGENCY &

PROPOSAL # TOTAL $AMOUNT

EFFECTIVE DATES

%TIME

TITLE OF PROJECT

Cramer, M Dolan

ARK Biosciences Inst. ABI 262118 $110,400 7/1/08 to

6/30/09 10% Plant Transgenics for Vaccines, Adjuvants and Therapeutics

McClure (ASTA), Cramer* (ASU), Varadan (UofA)

NSF EPSCoR RII EPS 0701890 ARK Match

$9M

$4.5M

8/14/07 to 8/14/10 20%

RII: Arkansas ASSET Initiative *Cramer leads “Plant-Powered Production” Center, one of two multi-institutional projects supported

Radin, Cramer, (BioStrategies)

USDA SBIR Phase II to BioStrategies LC

$350,000 9/1/08 to 8/31/10 5% Phase II: Plant-based Bioproduction of Chicken Il-12

Adjuvant for Bird Flu Vaccine

Huang, Cramer, Jennings (UALR)

EPSCoR P3 Collab. Seed Grant P3-101

$229,791 5/15/08 to 3/15/10 5%

Efficient Algorithms for Protein Structure Prediction and Applications in RTB Binding Occupancy Determination

Maureen C. Dolan

Research Assistant Professor Arkansas Biosciences Institute at Arkansas State University

P.O. Box 639, Arkansas State University, State University, AR 72467 (870) 680-4359, [email protected]

Professional Preparation. B.S. 1987 Biology and Chemistry, Quincy University, Quincy IL Graduated with honors: Summa Cum Laude and Bonaventure Award M.S. 1990 Biochemistry: Muscle Biology, Iowa State University Thesis Advisor: Dr. Richard M. Robson Thesis: Isolation & Characterization of Mammalian Smooth Muscle Talin Ph.D. 1996 Biochemistry and Molecular Biology, University of Florida Mentor: Dr. Harry S. Nick Dissertation: Glucocorticoid & Cytokine Regulation of Cytoplasmic Phospholipase A2 Gene Expression Postdoc 1999 Plant Molecular Biology, Horticultural Sciences, University of Florida Laboratory of Dr. Robert Ferl Appointments and Employment. 2004- Research Assistant Professor at the Arkansas Biosciences Institute, Arkansas State University 2005- Co-founder, Nature West, Inc., Jonesboro, AR 2004- Co-founder, Applied Food Technologies, LLC., Blacksburg, VA 2001- Co-founder and VP Research, Nature Diagnostics, Inc. Blacksburg, VA 2000-2004 Faculty Research Scientist in the laboratory of Dr. Carole Cramer Fralin Biotechnology Center, Virginia Tech University 1996-1999 Post-doctoral Associate in the laboratory of Dr. Robert Ferl, Department

of Horticultural Sciences, University of Florida 1990-1996 Graduate Assistant in the laboratory of Dr. Harry Nick, Department of

Biochemistry and Molecular Biology, University of Florida 1993 Collaborative project in the laboratory of Dr. Kenneth Adler, College of

Veterinary Medicine, North Carolina State University 1987-1990 Graduate Assistant in the laboratory of Dr. Richard Robson, Department

of Biochemistry and Biophysics, Iowa State University 1987 Summer Lab Assistant in the laboratory of Dr. David McCarroll American Red Cross, Peoria, IL 1986 Undergraduate Summer Research Internship-American Red Cross in laboratory of Dr. David McCarroll University of Illinois Medical Center, Peoria, IL

1 M.Dolan, Feb. 2009


Publications. Medrano, G., Dolan, M.C., Stephens, N.T., McMickle, A., Erf, G., Radin, D. and Cramer C.L.

Efficient plant-based production of chicken IL-12 yields a strong immunostimulatory cytokine. submitted to J Immunol. February 2009

Medrano, G., Reidy, M.J., Liu, J., Ayala, J., Dolan, M.C. and Cramer C.L. 2008 Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants. In: “Recombinant Proteins from plants”, L. Faye, and V. Gomord, eds. Methods and Protocols. Series: Methods in Molecular Biology. Humana Press, Totowa, NJ; 483:41-50.

Woffenden B.J., Ñopo L.H., Cramer C.L., Dolan M.C. and Medina-Bolivar, F. 2008. Expression of a ricin B:F1:V fusion protein in tobacco hairy roots: steps toward a novel pneumonic plague vaccine. . Electronic J Integrative Biosci. 3:10-19.

Liu, J., Dolan, M.C., Reidy, M., and Cramer, C.L.. 2008. Production of bioactive single-chain murine IL-12 in transgenic plants. J Interferon Cytokine Res 28(6):381-92..

Medina-Bolivar F., Condori J., Rimando A., Hubstenberger J., Shelton K., Bennett S., Dolan M.C. 2007. Production and secretion of resveratrol in hairy root cultures of peanut. Phytochemistry 68:1992-2003.

Reed, D., Nopo-Olazabal, L., Funk, V., Woffenden, B., Reidy, M., Dolan, MC., Cramer, C.L. and Medina-Bolivar, F. 2005. Expression of functional hexahistidine-tagged ricin B in tobacco Plant Cell Reports 24:15-24.

Dolan-O’Keefe, M., Chow, V., Monnier, J., Visner, G.A., and Nick, H.S. 2000. Transcriptional regulation and structural organization of the human cytosolic phospholipase A2 gene. Amer. J. Physiol. 78, L649-L657.

Dolan-O’Keefe, M. and Nick, H.S. 1999. Inhibition of cytoplasmic phospholipase A2 expression by glucocorticoids in rat intestinal epithelial cells. Gastroenterology 116:855-64.

Fisher, B.M., Krunkosky, T.M., Wright, D., Dolan-O'Keefe, M.C. and Adler, K.B. 1995. Tumor Necrosis Factor (TNF-α) Stimulates Mucin Secretion and Gene Expression in Epithelium In Vitro. Chest 107:133S-135S.

McCarroll, D.R., Lathrop, S.A., Dolan, M.C., and McDonald, T.P. 1987. Canine von Willebrand Factor Expresses a Multimeric Composition Similar to Human Homolog. Exper. Hemat. 15:1060-1067.

Book Chapters Dolan, M.C. 2007 Contributor of Features in: Criminalistics: Forensic Science and Crime Scene Investigation, Ed. James Girard, Jones and Barlett, Inc. Sudbury, MA. Patent Applications (pending). Medina-Bolivar F., Dolan M.C., Bennett S., Condori J., Hubstenberger J. (2007) “Production

of stilbenes in hairy roots” Patent Application N. 11773178/PCT/US07/72756. Cramer,C.L., Reidy M.J. and Dolan M.C.. (2008) “Methods of delivery of molecules to cells

using ricin subunit & compositions relating to same” Patent Application N. 60/944193. Cramer,C.L., Radin, D., Dolan, M.C., Medrano, G. (2008) “Plant-based expression of avian interleukin-12 and methods of producing and using same” Provisional N. 170008P. Recent National/International Meeting Presentations/Posters. Medrano, G., Stephens, N., Radin, D., Dolan, M.C., and Cramer, CL. “Bioactive chicken IL-

12: Plant-based production platform compatible with veterinary vaccine applications” International Cytokine 2008 Meeting; Montreal Canada; Oct. 12-16, 2008 Poster.


Medina-Bolivar F, Srivatsan M, Condori J, Sivakumar G, Badanavalu M, Dolan M.C. 2008. “Production and Neuroprotective Properties of Natural Resveratrol Analogs from Hairy Root Cultures”. World Congress on In Vitro Biology. June 2008. Presentation

Medina-Bolivar F., Condori J., Sivakumar G., Badanavalu M., Srivatsan M, Dolan M.C. 2008 “Production of Bioactive Resveratrol Analogues in Hairy Roots of Peanut”. SAAS Conference. Dallas, Texas. Feb 4, 2008 Presentation.

Cramer, C.L., Reidy M., and Dolan, M.C. 2007. “Delivery of proteins and small molecules to animal cells using ricin subunit B as a carrier”, Biocontact Quebec 2007 –Quebec City Canada Oct. 3-5, 2007. Presentation.

Dolan, M.C. , Medina-Bolivar, F. and Bennett, S. 2007. “Production of bioactive stilbenes in hairy root cultures of plants”, Biocontact Quebec 2007 –Quebec City Canada Oct. 3-5, 2007. Presentation.

Sivakumar, G. and Condori, J., Hannigan, R., Dolan, M.C. Medina-Bolivar, F. 2007. HPLC-MS screening for resveratrol and its derivatives in hairy root cultures of peanut, Phytochemical Society of North America Meeting St. Louis, MO, July 21-25, 2007. Poster.

Medrano, G., Reidy, M., Liu, J., Ayala, J., Dolan, M.C., and Cramer, C.L. 2007. “Test Driving your Transgene for Productivity in Plants” PBVA 2007 Meeting; Verona, Italy Jun 18-20, 2007. Poster.

Reidy, J.J., Liu, J., Dolan, M.C., and Cramer, C.L. 2007. Carrier/delivery potential of non-toxic, recombinant ricin B subunit for plant-derived vaccine components. PBVA 2007, Verona, Italy, June 18-20, 2007. Poster.

Dolan, M.C., S. Green, A. Christian, R. Hannigan. 2006. Undergraduate education at the agriculture- environmental science- biotechnology crossroads. National Academies of Sciences Leadership Summit to Effect Change in Agricultural Undergraduate Education. October 2006. Washington, DC. Poster and Invited ASU Representative

Dolan, M.C., J. Liu, M. Reidy, J. Ayala, G. Medrano, and C.L. Cramer. 2006. Integrative adjuvant and carrier technologies empowering plant-based vaccines, IAB 2006 Meeting –New Cells for New Vaccines: Focus on Plant and Insect Cell Technologies, Coral Gables, FL. September 23-25, 2006. Poster.

Medina-Bolivar, F, Dolan, M.C, and S. Bennett “Development of a streamlined, DNA-based diagnostic platform for black cohosh authentication” International Conference for Quality and Safety Issues Related to Botanicals; Aug 2005 Poster.

Dolan, M.C., 2005. “Advantages of DNA-based methods for species identification of fish and seafood products” 2005. International Food Technologists Meeting; New Orleans, LA July 2005. Invited Speaker

Dolan, M.C., Liu J, Russell M, and Cramer CL, 2005. “Transgenic plants for the bioexpression of human interleukins as adjuvants and immunomodulators”, International Conference on Plant-based Vaccines and Adjuvants, Prague, Czech Republic, Jun, 2005. Poster.

Dolan, M.C., 2005. “Finding Nemo with FTA: Seafood Species Identification with FTA Technology”, Plant&Animal Genome Conference, 2005. San Deigo, CA Jan. 2005. Invited Speaker.


Grantsmanship. Current Arkansas Biosciences Institute (ABI 5-45031) C.L. Cramer (PI), M. Dolan (coPI)

“Plant Transgenics for Vaccines, Adjuvants and Therapeutics” 7/1/07– 6/30/09 $ 110,400 Role: coPI NSF EPSCoR ASSET Project 2: Plant-based Bioproduction and the Arkansas P3 (Plant-Powered Production) Center C.L. Cramer (PI) $1,900,000; 9/15/07-6/30/08

i. NSF-EPSCoR P3/Outreach subaward “Linking Plant-based Bioproduction to Multi-Institutional K-14 Science Outreach” Coordinating Educational Outreach linked with the NSF EPSCoR P3 grant that focuses on the P3 Center institutions’ strengths in biotechnology applied to agriculture & medicine. 8/1/08-7/31/09 $9,024 Role: Interim Outreach Coordinator

ii. NSF P3 Seed Grant #P3009, A. Lorence, M. Dolan, V. Srivastava “Role of Ascorbate in mitigating ER and cellular stress associated with transient and stable plant-based protein production” 5/16/08-11/15/09 $249,860 Role: coPI

iii. NSF P3 Seed Grant #P3003, F. Medina-Bolivar, J. Carrier, M. Dolan

“Regulation, production and purification of bioactive stilbenoids from hairy root cultures of peanut”

5/16/08-11/15/09 $248,250 Role: coPI

USDA SBIR Phase II ARKK-2008-02304, BioStrategies LC/D. Radin (PI) ASU Subcontract: C. Cramer & M. Dolan

“Plant-based Bioproduction of Chicken Il-12 Adjuvant for Bird Flu Vaccine”. 9/1/08–8/31/10 $350,000 (ASU Subcontract $119,347) Role: coPI of ASU subcontract Arkansas Biosciences Institute Seed Grant, PIs: R. Buchanan, M. Dolan, Sarah Blossom “Maternal smoking and neuroimmune modulation involving altered expression of nicotine sensitive acetylcholine receptors in developing brain and immune system 12/1/08–11/31/10 $60,000 (ASU: $30,000) Role: coPI of ASU grant


Arkansas Science & Technology Authority ASTA08-WRF-STEM023 CL Cramer (PI) coPIs: MC Dolan, E Benjamin, and C Dowling “ASU’s CSI Summer Camp – Attracting Young Investigators to Science and Technology through Crime Scene Investigation” 5/16/08–12/16/08 $10,000 Recently Completed Grants USDA SBIR Phase I 2007-33610-17978 BioStrategies LC/D. Radin (PI) ASU Subcontract: C. Cramer (PI) and M. Dolan (coPI) “Plant-based Bioproduction of Chicken Il-12 Adjuvant for Bird Flu Vaccine” 7/1/07 – 2/28/08 $79,875 (ASU subcontract: $26,619) Role: coPI of ASU subcontract Company Commercialization Grants: Products (kits and services) developed on completion of the following USDA SBIR’s for crab, catfish and tuna speciation grants listed below are currently being commercially sold and distributed as kits and as an in-house testing service through our company Applied Food Technologies, LLC; Blacksburg, VA. USDA SBIR Phase II 2004-33610-15071, APL Science; LeeAnn Applewhite (PI) Nature Diagnostics Subcontract: S. Bennett (PI); M. Dolan (coPI) “Species Authentication of Catfish Using Protein and DNA Based Diagnostics” 09/04 – 08/06 $296,000 Role: coPI of Nature Diagnostic subcontract USDA SBIR Phase II 2003-33610-14015, APL Science; LeeAnn Applewhite (PI) Nature Diagnostics Subcontract: S. Bennett (PI); M. Dolan (coPI) “Species Identification of Canned Crabmeat by a Discriminating PCR-Based Diagnostic” 09/03 – 08/05 $296,000 Role: coPI of Nature Diagnostic subcontract Teaching Experience. 2005- Guest Lecturer at Arkansas State University

Survey of Forensic Science (FOSC2013) Special Topics in Molecular Biosciences (MBS7121) Immunology Lab (BIOL4282/5282) Soil Microbiology (PSSC4883/5883) Biology of the Cell (BIOL1013)

2002-2004 Guest Lecturer at Virginia Tech University: Molecular Biology (BIOL3774); Biotechnology Applications (BCHM4784) 1991-1993 Teaching Assistant at University of Florida


Advanced Biochemistry (BCH4024) 1988-1989 Teaching Assistant at Iowa State University Advanced Radiobiochemistry (BB524); General Biochemistry (BB352) 1987 Teaching Lab Assistant at Quincy College Introductory Chemistry (CHEM 160) Research Mentorship/Advisor Activity. Arkansas State University

Graduate student advisees 2008- Ph.D. Co-Advisor – Maria-Isabelle Ferrand; MBS Ph.D. student

Ph.D. Dissertation Committee Member

Dr. Jianyen Liu – Ph.D. May 2007, PPWS, Virginia Tech University Mr. Jose Condori –MBS Ph.D. candidate; 2006- Mr. David Clarke – EVS Ph.D. candidate; 2005- Mr. Walter Acosta –MBS Ph.D. candidate; 2007- Mr. Audrei Dabul -MBS Ph.D. student; 2007- Mr. Siddique Aboobucker-MBS Ph.D. student; 2008- Mr. Cody Ashby –MBS Ph.D. student: 2008-

Undergraduate Research Advisor

Lindsey Beall – FOSC (Spring, ‘07) William Wilson – BIOL (Spring ‘009)

Prior Research Mentorship Activity 2001-2004 Virginia Tech University, Fralin Biotechnology Center Undergraduate Research Mentor: Natalie Warholic (Biol.’02), Sarah Baas

(Honors Biol. ‘04), Alan Sheeley (Biol. ‘04), Alison Colanduoni (Biol. ‘03) 1992-1995 University of Florida, Biochemistry and Molecular Biology Department Undergraduate and Clinical Fellow Research mentor while in the laboratory of Dr. Harry Nick: 2 undergraduates; 2 Clinical Fellows K-14 Educational Outreach Activity. Arkansas State University 2005-present Coordinator of ABI Biotechnology Educational Outreach Program.

This K-14 Outreach program brings more than K-12 students/5-50 teachers per month as well as supporting a number of campus-wide educational activities including tours/demos for our a number of ASU undergraduate programs. The major effort of the program involves offering ~4days/month an opportunity for school groups and science clubs to visit and tour the ABI research facility and do a hands-on biotechnology-based lab exercise. This unique and free venue for middle and high school students is done in collaboration with the Delta and Crowley’s Ridge Educational Science Specialists. In addition to coordinating the program, I designed several laboratory hands-on activities for students and serve as a regular tour guide and demo instructor.


2005-present Faculty Instructor - ASU Crime Scene Investigation (CSI) Summer Camp Involved in the original concept design and serve as lead instructor of the Biological Crime Scene Evidence Lab Team. There are 2-1 week sessions offered to high school (grade 10-12) where students learn basic forensic science lab skills to “solve the crime” by weeks end. This camp is sponsored by the College of Arts and Humanities in collaboration with the Forensic Science Program, Departments of Criminology, Chemistry, Biology and Health Sciences and ABI.

2007 Electrophoresis Basics Workshop – Instructor; 1 day science teacher workshop sponsored by the ASU K-12 Delta Education Specialist.

2006 CSI Teachers Workshop – Biological Lab; 2 day teacher science workshop sponsored by the Crowley’s Ridge Co-op; July 2006

2006-present Faculty Science Mentor for ASU campus Girls of Promise annual event for 8th grade girls. 2005 & 2007 Faculty Science Mentor for ASU Women in Science and Technology day event for 5th-6th grade girls. Prior Educational Outreach 2001-2004 Instructor for Beginners Plant DNA Biotechnology Summer Workshop (teachers); Fralin Biotech Center; Virginia

Tech University 2003-2004 Instructor for Advanced Plant DNA Biotechnology Summer Workshop (teachers); Fralin Biotech Center; Virginia Tech University 2003 Laboratory Mentor (high school students) for National DNA Day at Fralin Biotech. Center, Virginia Tech University 2003 Volunteer Science Advisor and Instructor for St. Mary’s Grade School, Blacksburg, VA

• Grade K – Germs Lesson • Grade 4-5 – DNA and Microscope Workshop at Fralin Biotech

Honors and Awards. 2008 Faculty Service Award from the Forensic Science Program; College of Sciences and Mathematics 1994 American Gastroenterology Association Foundation 1994 Student Abstract Award 1992-1993 Division of Sponsored Research Grant, University of Florida 1987 Bonaventure Award and Summa Cum Laude, Quincy College 1987 Who’s Who Among Students In American Universities and Colleges 1983-1987 Solano Award Scholarship, Quincy College 1982 American Cancer Society Young Scientist Award

Summer Internship Program; St. Mary's Hospital, Quincy, Illinois Professional Affiliations. 2001-present International Food Technologist 2000-present International Society for Interferon and Cytokine Research



CURRICULUM VITAE ANNE AURIEMMA GRIPPO

Professional Experience 2008 Interim Director, Arkansas State University Environmental Science Doctoral Program 2007-present Associate Director, ASU Molecular Biosciences Doctoral Program 2006 Interim Director, ASU Molecular Biosciences Doctoral Program 2000-present Associate Professor of Biology, Arkansas State University 1995-2000 Assistant Professor of Biology, Arkansas State University 1992-1995 Instructor of Biochemistry, Department of Biochemistry & Molecular Biology, Pennsylvania State University 1987-1992 Postdoctoral Scholar, Dairy Breeding Research Center, Departments of Dairy & Animal Science and Physiology, Pennsylvania State University 1986-1987 Postdoctoral Scholar, Department of Molecular & Cell Biology, Pennsylvania State University 1984-1986 Research Assistant, Department of Medicinal Chemistry, University of North Carolina, Chapel Hill Academic Training 1987 Ph.D. Medicinal Chemistry, University of North Carolina, Chapel Hill, NC

Dissertation Title: Sesquiterpene lactones: Mechanism of antineoplastic activity; relationship of cellular glutathione to cytotoxicity; and disposition

1979 B.S. Chemistry; Biology minor, Fairleigh Dickinson University, Madison, NJ Honors Research Title: Synthesis of some allenic retinoids as possible antitumor agents

Grants 2009 NSF EPSCOR P3 (co-I/Devareddy)($107,964) 2009-2010 2007 NSF GK-12 Proposal (co-I/Christian) ($445,082) 2005- AR INBRE (co-I/Buchanan)($24,920 yearly) 2008 2004 ASU/AR Biosciences Research Grant (co-PI) ($132,918) 2003 ASU/AR Biosciences Research Grant (co-PI) ($219,320) 2003 AR BRIN Faculty Academic Year Research Award (co-PI) ($11,330) 2002 AR BRIN Equipment Grant ($23,300) 2002 AR Biomedical Research Infrastructure Network (BRIN) Summer Research Mentoring Award

(co-PI) ($13,110) 2001 NSF Chemistry Instrumentation Grant (co-PI) ($79,624) 2000 ASU Faculty Research Grant (co-PI) ($10,000) 1999 SURF-Silo Undergraduate Research Grant ($3,862) 1999 Arkansas Science and Technology Authority Basic Research Award ($26,084) 1998 Nathan Deutsch Research Award ($400) 1996 ASU Faculty Research Grant ($9,750) Scholarly Publications 1. Brown, CE, S Trauth, RS Grippo, BJ Gurley, AA Grippo. 2008. Combined effects of ephedrine-containing dietary supplements, caffeine, and nicotine on morphology and ultrastructure of rat hearts. Tox. Sciences (submitted for review) 2. Grippo, AA, K Capps, B Rougeau, BJ Gurley. 2007. Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplements. Ann. Pharmacother. 41:1375-82. 3. Grippo, AA, B Hamilton, R Hannigan, BJ Gurley. 2006. Metal content of ephedra-containing dietary

supplements and other select botanicals. Am. J. Health Syst. Pharm. 63:635-644. 4. Grippo, AA, Y Luo, B Rougeau WV Wyatt. 2000. HPLC analysis of mono-saccharides in whole and regional, staged bovine oviductal fluid. Theriogenology. 35:717-721. 5. Grippo, AA, Y Xie, B Rougeau WV Wyatt. 1999. Analysis of phytoestrogens by high pressure liquid chromatography. J. AR Acad. Sci. 53:61-66. 6. Grippo, AA, AL Way G.J Killian. 1995. Effect of bovine ampullary and isthmic oviductal fluid on motility, acrosome reaction and fertility of bull spermatozoa. J. Reprod. Fertil. 105:57-64. 7. Grippo, AA, SH Anderson, M.A Henault, G.JKillian. 1994. Cholesterol, phospholipid and phosphor-lipase activity of ampullary and isthmic fluid from the bovine oviduct. J. Reprod. Fertil. 102:87-93. 8. Grippo, AA, M.A Henault, SH Anderson, GJ Killian. 1992. Cation concentrations in fluid from the oviduct ampulla and isthmus of cows during the estrous cycle. J. Dairy Sci. 75:58-65. 9. Kavanaugh, JF, AA Grippo, GJ Killian. 1992. Cannulation of the bovine ampullary and isthmic oviduct. J. Invest. Surg. 5:11-17. 10. Grippo, AA, IH Hall, H Kiyokawa, O Muraoka, Y-C Shen, K-H Lee. 1992. The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells. Drug Design Disc. 8:191-206. 11. Grippo, AA, SD Wyrick, KH Lee, RP Shrewsbury, IH Hall. 1991. Disposition of an antineoplastic sesquiterpene lactone, [3H]-plenolin, in BDF1 mice. Pl. Med. 7:299-314. 12. Hall, IH, AA Grippo, DJ Holbrook, JJ Chang, LM Yang, SG Chaney, K.H Lee. 1990. Renal, hepatic, cardiac and thymic acute toxicity afforded by bis(helenalinyl) malonate in BDF1 mice. Toxicology 65:205-216. 13. Hall, IH, AA Grippo, DJ Holrook, GB Roberts, HC.Lin, HL Kim, KH Lee. 1989. Role of thiol agents in protecting against the toxicity of helenalin in tumor-bearing mice. Planta Med. 5:513-517. 14. Wedler, FC, BW Ley and AA Grippo. 1989. Manganese (II) dynamics and distribution in glial cells cultured from chick cerebral cortex. Neurochem. Res. 14:1129-1135. 15. Tholey, G, M Ledig, P Kopp, L Sargentini-Maier, M Leroy, AA Grippo , FC Wedler. 1988. Levels and subcellular distribution of physiologically important metal ions in neuronal cells cultured from chick embryo cerebral cortex. Neurochem. Res. 13:1163-1167. 16. Tholey, G, M Ledig, P Mandel, L Sargentini, AH Frivole, M Leroy, AA Grippo , FC Wedler. 1988. Concentrations of physiologically important metal ions in glial cells cultured from chick cerebral cortex. Neurochem. Res. 13:45-50. 17. Williams, WL, IH Hall, AA Grippo, CB Oswald, KH Lee, D Holbrook and S Chaney. 1988. Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl) malonate in vivo. J. Pharm. Sci. 77:178-184. 18. Chapman, DE, GB Roberts, DJ Reynolds, AA Grippo, DJ Holbrook, IH Hall, SG Chaney, J Chang, K. H. Lee. 1988. Acute toxicity of helenalin in BDF1 mice. Fund. App. Toxicology 10:302-312. 19. Hall, IH, WL Williams, Jr., AA Grippo, K-H Lee, DJ Holbrook and SG Chaney. 1988. Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia cells in culture by sesquiterpene lactones. Anticancer Res. 8:33-42. 20. Wyrick, SD, FT Smith, WE Kemp and AA Grippo. 1987. Effects of [(N-alkyl-1H,3H-isoindolin-1,3-dione-5-yl)oxy]-alkanoic acids, [(N-alkyl-1H,3H-isoindolin-1-one-5-yl)oxy]-butanoic acids and related derivatives on chloride influx in primary astroglial cultures. J. Medicinal Chem. 30:1798-1806. 21. Hall, IH, AA Grippo, K-H Lee, SG Chaney and DJ Holbrook. 1987. Effect of helenalin and bis(helenalinyl) malonate on nucleic acid and protein synthesis in human KB carcinoma cells. Pharm. Res. 4:509-515. Presentations 1. A Ratti, B Hill, AA Grippo. Early cardiovascular changes with estrogen depletion. Endocrine Society; P2-505; p. 523 (2008) 2. A Ratti, B Hill, A Grippo. Estrogen depletion: Physiological and molecular cardiovascular changes. Arkansas Biosciences Institute Fall Research Symposium (2007)

3. AA Grippo, C Brown, S Trauth, R Grippo, B Gurley. Metabolife and Its Constituents Increase Atypical Cardiac Cells, An Effect Exacerbated by Nicotine. Soc. Toxicol. (2006) 4. B Gurley, SF Gardner, K Williams, A Grippo, Hemodynamic and electrocardiographic effects of an “Ephedra-free” dietary supplement (Metabolife UltraTM). Am. Soc. Clin. Phamacol. Ther. (2006) 5. C Brown, P MacFarland, S Trauth, R Grippo, A Grippo, Cardiovascular effects of combined nicotine and ephedra on male and female rats. SCC Soc. Toxicol. (2005) 6. AA Grippo, S Snipes, R Raeven, W Kennedy, W Humphrey. Genistein effects on sheep reproduction. Invited lecture: So. Assoc. Agric. Sci. (2005) 7. AA Grippo, AA Stokes, CE Brown, L Rosa, M Mary, RS Grippo, S Trauth, BJ Gurley. Does ephedra alone effect rat cardiovascular physiology and tissue morphology differently than ephedra contained in Metabolife? AR Biotech. Inst. Symposium (2004). 8. AA Grippo, S Snipes, A Davis, W Humphrey. Detection of genistein in serum and oviductal fluid of ewes administered Biochanin A. Biol. Reprod. 64 (Suppl. 1):89 (2004). 9. AA Grippo. Studies of the effects of phytoestrogens on mammalian reproduction. Invited lecture: University of Memphis Biology Seminar Series (2003). 10. K Capps, B Rougeau, B Gurley, A Grippo. Bioflavonoids in herbal supplements. Southern Regional Discussion Group, Amer. Assoc. Pharm. Sci. (2003). 11. BT Hamilton, RE Hannigan, BJ Gurley, AA Grippo. Metals concentrations in over-the-counter herbal preparations. Southern Regional Discussion Group, Amer. Assoc. Pharm. Sci. (2003). 12. AA Grippo. Reproductive toxicology of phytoestrogens. Invited lecture: UC Davis Toxicology Seminar Series (2001). 13. WD Bryant, W Humphrey, AA Grippo. The effect of estrogenic agents on ram sperm acrosome reaction. 21st Annual Meeting, Soc. Env. Tox. & Chem. (2000). 14. Y Luo, B Rougeau, W Wyatt, A Grippo. Availability of monosaccharides in whole and regional, staged bovine oviductal fluid. Biol. Reprod. 60 (Suppl. 1):158 (1999). 15. AA Grippo, Y Xie, B Rougeau, WV Wyatt. Analysis of phytoestrogens by high pressure liquid chromatography. Proc. AR Acad Sci.: 92 (1999) 16. W Hayes, J Pierce, J Farris, A Grippo. Vitellogenin purification from the slider turtle Trachemys scripta. Proc. AR Acad. Sci.:18 (1998) 17. A Strecker, A Grippo. Displacement of steroid hormones from sex hormone binding globulin by phytoestrogens. Proc. AR Acad. Sci.:36 (1998) 18. E Winchester, J Farris, A Grippo, R. Grippo. Effects of aldicarb on cholinesterase activity of two freshwater molluscs (Ligumia subrostrata and Corbicula fluminea). Soc. Env. Tox. & Chem. (1997) 19. GJ Killian, AA Grippo. Incubation in ampullary oviductal fluid improves the ability of sperm to fertilize bovine oocytes in vitro. Proc. of the 12th Int. Congress on Animal Repro. 2:650-652 (1992) 20. MA Henault, AL Way, AA Grippo, G. J. Killian. A heterospermic, competitive penetration assay utilizing zona-free bovine oocytes. Biol. of Reprod. 46(Suppl. 1):74 (1992) 21. RS King, AA Grippo, GJ Killian. Bovine estrus-associated protein stimulates capacitation of bull sperm. Biol. of Reprod. 44(Suppl. 1):135 (1991) 22. AA Grippo, DA Chapman, GJ Killian. An improved assay for phospholipase A2 activity in sperm. J. Andrology 10:47 (1989) 23. SD Wyrick, FT Smith, AA Grippo. Synthesis of agents affecting astrocytic chloride influx. Proc. of the Meeting in Miniature, ACS Research Triangle Section (1986) 24. DE Chapman, GB Roberts, AA Grippo, IH Hall, SG Channey, J Chang, DJ Reynolds, DJ Holbrook. Acute toxicity of helenalin in BDF1 mice. The Toxicologist. 5:299 (1986) 25. AA Grippo, SD Wyrick, RP Shrewsbury, SG Chaney, DJ Holbrook, KH Lee, IH Hall. The disposition of [3H]-11,13-dihydrohelenalin, a derivative of the sesquiterpene lactone helenalin. The Pharmacologist. 27:109 (1985) 26. AA Grippo, W Williams, KH Lee, S Chaney, D Holbrook, IH Hall. Antineoplastic activity of the natural product helenalin. Proc. of the International Res. Congress on Natural Products (1985) 27. AA Grippo, IH Hall, DJ Holbrook, SG Chaney. The role of cellular levels of reduced glutathione on

the efficacy of an antitumor sesquiterpene lactone. Proc. of the ACS Southeastern Regional Meeting (1984) 28. AA Grippo, IH Hall, KH Lee, DJ Holbrook. The toxicology and mechanism of helenalin, an antitumor sesquiterpene lactone. Proc. of the ACS Southeastern Regional Meeting (1983) 29. JR Dyer, DR King, AM Auriemma. Studies of the reaction between carbon disulfide and sodium hydroxide. Proc. of the ACS Northeastern Regional Meeting (1979)

ELIZABETH E. HOOD, Ph.D. Arkansas State University

PO Box 2760 State University, AR 72467

Phone: 870-972-2694 Fax: 870-972-2336 [email protected]

SUMMARY

Thirty years experience in biology. Lipscomb Distinguished Professor of Agriculture at Arkansas State University. Previously, Associate Vice Chancellor for Research and Technology Transfer at ASU. Program Director in Molecular and Cellular Biosciences at the National Science Foundation. Leader in forming one of the world’s foremost transgenic plant research groups at ProdiGene, a plant biotechnology start-up company. Director of the cell biology group for plant production of therapeutic proteins at Pioneer Hi-Bred International, a Fortune 500 Company. Excellent communication skills. Internationally recognized for research program and associated expertise as evidenced by over 75 publications and patents as well as invitations to speak nationally and internationally. Advisor for Biotechnology graduate programs at several universities. Ph.D. in Plant biology awarded by Washington University and Master of Science in Botany awarded by Oklahoma State University.

PROFESSIONAL EXPERIENCE

ARKANSAS STATE UNIVERSITY—Jonesboro, Arkansas 2004-present Lipscomb Distinguished Professor of Agriculture (2008-present) Senior faculty in agricultural biotechnology; Director, Center for BioFuels and BioBased products Associate Vice Chancellor for Research and Technology Transfer. 2004-2008 Chief research officer for ASU responsible for grant proposal submission compliance; funding information dissemination; committees for compliance with federal guidelines in research; implementation of conflict of interest policy, contracts, invention disclosures and patent filing, and technology transfer in the interest of regional economic development. • Established the ASU Research and Innovation Foundation and associated infrastructure • Instituted an Intellectual Property policy • Instituted a Conflict of Interest and Commitment policy • Filed several patent applications based on invention disclosures, a new activity for ASU • Lead discussions on Business Incubator and Research Park implementation plan • Instituted an ORTT Newsletter • Composed new RFPs for internal funding sources • Generated database for pre-award tracking and reporting • Manage government relations for Congressional funding

o $6 MM in FY 2005 o $7 MM in FY 2006 o $4 MM in FY 2007 (Dept. of Defense and Homeland Security) o $3.5 MM with Dept. of Energy

• Spear-headed Symposium and Workshop on Identity Solutions with grant from AR Science and Technology Authority.

• Spear-headed effort to secure state-wide EPSCOR infrastructure grant from NSF • Mentored 3 start-up technology companies. • Established research investment with indirect cost recovery budget. • Established an active research laboratory in plant-based enzyme production technologies. • Established a start-up company to produce enzymes in transgenic plants for bio-based

products. NATIONAL SCIENCE FOUNDATION – Arlington, Virginia 2003-2004 Program Director, Molecular and Cellular Biosciences, Signal Transduction/Cellular Regulation program. Responsible for funding decisions on proposals submitted to the NSF from non-industry groups. Worked with colleagues to assign proposals to appropriate panels, solicit peer reviews, assemble and direct

ELIZABETH E. HOOD, Ph.D. review panels, make funding decisions, manage program budget (~$10 million). Conducted site visits and outreach. PRODIGENE - College Station, Texas 1997 - 2004 Consultant, Industrial Proteins (2003-2004) Responsible for oversight and advice for the industrial enzymes program; assisted with progress reports, strategy, grant writing and project review. Principal Investigator, SBIR grants, Industrial Proteins (2003) Responsible for achieving objectives laid out in each of 2 Phase I SBIR awards from the USDA. Projects: 1) Cellulases for Biomass Conversion from the Transgenic Maize Production System; and 2) Efficacy of Recombinant Redox Enzymes from Corn in Wood and Textile Applications. • Wrote applications meriting the awards—two awards from one panel. • Organized applications trials for two redox enzymes with three collaborators and established

contracts. • Organized employees at ProdiGene to develop and perform assays to determine expression of

cellulases in transgenic maize. • Wrote successful Phase II application for the cellulase project. Vice President, Industrial Proteins Business Unit (2002) Responsible for setting business unit goals and writing the business plan for this unit within ProdiGene. Established and maintained business unit budget. Also managed the program in biomass conversion. • Developed the product plan for two protein products from research and negotiated a contract for

commercialization of products developed through a collaborator. • Established and managed contractual applications testing in numerous industries resulting in

identification of lucrative product markets to pursue. • Established and managed critical contracts for research collaborations resulting in added value to the

company. • Evaluated invention disclosures and filed intellectual property documentation. • Participated fully in the management of the company and represented the company and business unit

at scientific and trade meetings generating increased interest in the company. • Assembled a deregulation package for first product to present to USDA, meeting all time and

budgetary constraints. Vice President, Technology (1999 - 2002) Responsible for setting priorities and goals for 30 full and part-time staff; Functional groups included: Molecular Biology, Transformation, Biochemistry, Genetics, Greenhouse, Laboratory Support Services and New Technologies. • Developed, implemented and managed a technology program that addressed goals in foreign protein

expression, plant health and research efficiency. • Represented the company in developing new collaborative efforts by presenting talks on the

technology of the company, developing collaborator confidence in company technology. • Reviewed and implemented programs that improved the efficiency of the process for developing

products in the research group. • Wrote business rules for, implemented and managed database for company research groups that

contained over two million entries. • Managed product projects for major company collaboration on two products, motivating the

collaborator to increase the project numbers three-fold. • Acted as liaison with outside patent counsel for searches, disclosures and patent writing. • Developed a program in biomass conversion that encompassed design of research,

applications for funding, gathering tools and identification of collaborators. Director, Cell Biology (1997 - 1999) • Developed and implemented a transformation system for maize suitable for commercial production of

protein products. • Hired personnel and set up group to perform transformation and cell biology experiments, including

DNA hybridization screening of transgenic plants.

ELIZABETH E. HOOD, Ph.D. • Led effort to achieve USDA approval for greenhouse and laboratory facilities to conduct experiments

with transgenic plants. • Designed the laboratory layout and greenhouse for new building. Set up greenhouse operations in

first ProdiGene location. PIONEER HI-BRED INTERNATIONAL - Johnston, IA 1994 - 1996 Research Manager, Cell Biology • Set up cell biology group for new functional area, Protein Products, within Pioneer research. • Set up transformation systems for soybean, canola and corn. • Redesigned laboratory for more efficient use of space and to allow addition of equipment. • Managed product development for first Protein Products collaborator comprising four products. One

of the products, avidin, was the first protein commercialized from a transgenic plant. Two other products were the second and third protein products commercialized from transgenic plants.

UTAH STATE UNIVERSITY, Logan UT 1988 – 1994 Assistant Professor of Biology SWEDISH UNIV. OF AGRICULTURAL SCIENCES, Uppsala, Sweden 1988 Visiting Researcher WASHINGTON UNIVERSITY, St. Louis MO 1981 - 1988 Ph.D. student and Post doctoral research associate

EDUCATION

Ph.D. Washington University, St. Louis, MO, Plant Biology 1985 M.S. Oklahoma State University, Stillwater, OK, Botany 1980 B.A. University of Oklahoma, Norman, OK, Sociology 1974

ELIZABETH E. HOOD, Ph.D.


SUPPLEMENTAL INFORMATION

OTHER PROFESSIONAL EXPERIENCE

2005-2007 Handling Editor, Reviews Editor, Plant Biotechnology Journal 2004-present Specialty Crops Regulatory Assistance Steering committee 2003 USDA Risk Assessment Panel 2003-Present Editorial Board, Transgenic Research 2002-2005 Advisory Board-TAMU Institute of Food Science and Engineering 2002 Development Board-TAMU Center for Teaching Excellence 2002-present Advisory Board, Plant Biotechnology Journal 2002 NSF, BES panel member 2000-2007 Member, Faculty of 1000, Agricultural Biotechnology 2001 Member NRI, Non-Food Uses of Crops Panel, USDA, CSREES 2000-2003 Editorial Board, Molecular Breeding 2000-2002 Member, TAMU, Center for Nutrition, Health and Food Genomics 2000 Workshop organizer, IBC conference; Agricultural Genomics 2000-2002 Advisor, Univ. of South Carolina Professional Master's Program 1999 Adjunct Professor, Dept. of Biology, Texas A&M University 1997-2005 Adjunct Professor, Dept. of Biochem/Biophys Texas A&M Univ. 1997-2004 TAMU Molec and Environmental Plant Sciences (MEPS) Faculty 1992 Specialist on Review Panel; Nordic Fund, Sweden 1990 NSF panel member, Teacher Preparation and Enhancement

RESEARCH INTERESTS

Renewable resources—particularly biomass to ethanol Foreign gene expression in transgenic plants Plant cell wall structure and function Plant cell biology and protein targeting

HONORS AND PROFESSIONAL AFFILIATIONS

Member, American Society of Plant Biologists (ASPB) 1977-present Chair, Board of Trustees, ASPB 2004-2005 Board of Trustees, ASPB 2002-2005 Candidate for President, ASPB 2002 Executive Committee, ASPB 2002, 2005 Chair, ASPB Women in Plant Biology Committee, 2001-2002 Member, International Society for Plant Molecular Biology Member, Society for In Vitro Biology 2000-Woman to Watch, Business & Professional Women, Brazos County, TX Sigma Xi, Phi Kappa Phi

REFEREED PUBLICATIONS

Molecular farming

Hood, E.E., D.R. Witcher, S. Maddock, T. Meyer, C. Baszczynski, M. Bailey, P. Flynn, J. Register, L.

Marshall, D. Bond, E. Kulisek, A. Kusnadi, R. Evangelista, Z. Nikolov, C. Wooge, R.J. Mehigh, R. Hernan, W.K. Kappel, D. Ritland, C.P. Li and J.A. Howard 1997 Commercial production of avidin from transgenic maize: Characterization of transformant, production, processing, extraction and purification. Molecular Breeding 3:291-306

ELIZABETH E. HOOD, Ph.D. Witcher, D.R., E.E. Hood, D. Peterson, M. Bailey, D. Bond, A. Kusnadi, R. Evangelista, Z. Nikolov,

C. Wooge, R. Mehigh, W. Kappel, J.C. Register, and J.A. Howard 1998 Commercial production of β-glucuronidase (GUS): A model system for the production of proteins in plants. Molecular Breeding 4:301-312

Kusnadi, A.R., E.E. Hood, D.R. Witcher, J.A. Howard and Z.L. Nikolov 1998 Production and

purification of two recombinant proteins from transgenic corn Biotechnol. Prog. 14:149-155 Kusnadi, AR, RL Evangelista, EE Hood, JA Howard and ZL Nikolov 1998 Processing of transgenic

corn seed and its effect on the recovery of recombinant β-Glucuronidase Biotechnol and BioEngineering 60:44-52

Zhong, G.Y., D. Peterson, D.E. Delaney, M. Bailey, D.R. Witcher, J.C. Register III, D. Bond, C.-P. Li,

L. Marshall, E. Kulisek, D. Ritland, T. Meyer, E.E. Hood and J.A. Howard 1999 Commercial production of aprotinin in transgenic maize seeds Molecular Breeding 5: 345-356

Hood, E. and J. Howard 1999 Protein products from transgenic plants Agro-Food-Industry Hi-Tech,

3, Vol.10, May/June pp. 35-36 Hood, E. and J. Jilka 1999 Plant based production of xenogenic proteins Current Opinion in

Biotechnology, 10:4, 382-386 Jilka, J.M., E.E. Hood, R. Dose and J.A. Howard 1999 The benefits of proteins produced in

transgenic plants. AgBiotechNet, Vol. 1, September, ABN 027 Streatfield, S. J., J. M. Jilka, E. E. Hood, D. D. Turner, M. R. Bailey, J. M. Mayor, S. L. Woodard, K.

K. Beifuss, M. E. Horn, D. E. Delaney, I. R. Tizard and J. A. Howard 2001 Plant-based vaccines: unique advantages Vaccine 19:2742-2748

Streatfield, S.J., J.M. Mayor, D.K. Barker, C. Brooks, B.J. Lamphear, S.L. Woodard, K.K. Beifuss,

D.V.Vicuna, L.-A. Massey, M.E. Horn, D.E. Delaney, Z.L. Nikolov, E.E. Hood, J.M. Jilka and J.A. Howard 2002 Development of an edible subunit vaccine in corn against enterotoxigenic strains of Escherichia coli. In Vitro Cell. Dev. Biol.-Plant 38:11-17 (Highlighted in ‘In Vitro Report’)

Hood, E.E. 2002 From Green Plants to Industrial Enzymes Enzyme and Microbial Technology

30:279-283 Hood, E.E., Z.L. Nikolov 2002 Making therapeutic proteins in transgenic corn. Tutorial:

Manufacturing low-cost, high-purity, clinical-grade proteins in corn Genetic Engineering News 22:48

Hood, E.E., S.L. Woodard and M.E. Horn 2002 Antibody manufacturing in transgenic plants: Myths

and Realities Current Opinion in Biotechnology, 13, 630-635 Lamphear, B.J., Streatfield, S.J., Jilka, J.M., Brooks, C.A., Barker, D.K., Turner, D.D., Delaney, D.E.,

Garcia, M., Wiggins, B., Woodard, S.L., Hood, E.E., Tizard, I.R., Lawhorn, B. and Howard, J.A. 2002 Delivery of subunit vaccines in maize seed. J. Controlled Release, 85. 169-180

Hood, E.E., M.R. Bailey, K. Beifuss, M. Horn, M. Magallanes-Lundback, C. Drees, D. E. Delaney, R.

Clough and J. A. Howard 2003 Criteria for high-level expression of a fungal laccase gene in transgenic maize Plant Biotechnology Journal. 1, 129-140

Streatfield, S.J., Lane, J.R., Brooks, C.A., Barker, D.K., Poage, M.L., Mayor, J.M., Lamphear, B.J.,

Drees, C.F., Jilka, J.M., Hood, E.E. and Howard, J.A. 2003 Corn as a production system for human and animal vaccines Vaccine 21:812-815

Bailey, M.R., S.L. Woodard, E. Callaway, K Beifuss, D. Delaney, M. Magallanes-Lundback, J. Lane, M.E. Horn, M. Ward, F. Van Gastel, J.A. Howard, E.E. Hood 2004 Improved recovery of

ELIZABETH E. HOOD, Ph.D. active recombinant laccase from maize seed Applied Microbiology and Biotechnology 63(4):390-7, (2003 Epub)

Woodard, S.L., J.M. Mayor, M.R. Bailey, D.K. Barker, R.T. Love, J.R. Lane, D.E. Delaney, J.M.

McComas-Wagner, H.D. Mallubhotla, E.E. Hood, L.J. Dangott, S.E. Tichy and J.A. Howard. 2003 Maize-derived bovine trypsin: Characterization of the first large-scale, commercial protein product from transgenic plants. Biotechnology and Applied Biochemistry 38:123-130

Streatfield, S.J., M.E. Magallanes-Lundback, K.K. Beifuss, C.A. Brooks, R.L. Harkey, R.T. Love, J.

Bray, J.A. Howard, J.M. Jilka and E.E. Hood. 2004 Analysis of the maize polyubiquitin-1 promoter heat shock elements and generation of promoter variants with modified expression characteristics. Transgenic Research 13(4):299-312

Lamphear, BJ DK Barker, CA Brooks, DE Delaney, JR Lane, K Beifuss, R Love, K Thompson, J

Mayor, R Clough, R Harkey, M Poage, C Drees, ME Horn, SJ Streatfield, Z Nikolov, SL Woodard, EE Hood JM Jilka, and JA Howard. 2005 Expression of the Sweet Protein Brazzein in Maize for Production of a New Commercial Sweetener Plant Biotechnology J 3:103-114

Hood, EE 2004 Bioindustrial and Biopharmaceutical Products from Transgenic Plants Online

publication at 4th ICSC, Brisbane Australia http://www.cropscience.org.au/icsc2004/symposia/3/5/1955_hoode.htm

Howard, JA and Hood, EE. 2005 Bioindustrial and Biopharmaceutical Products Produced in Plants

Adv in Agron 85:91-124 Clough, RC, Beifuss, K, Lane, J, Pappu, K, Thompson, K, Bailey, MR, Delaney, DE, Harkey, R,

Drees, C, Howard, JA and Hood, EE. 2006 Recombinant manganese peroxidase from the white-rot fungus Phanerochaete chrysosporium is enzymatically active and accumulates to high levels in transgenic corn seed. Plant Biotechnology Journal 4:53-62

Hood, EE and Woodard, SL 2006 Commercialization of a Protein Product from Transgenic Maize, NABC

Report 17: Agricultural Biotechnology: Beyond Food and Energy to Health and the Environment: 147-158.

Howard, JA and Hood, EE 2007 Methods for growing nonfood products in transgenic plants; Crop

Science; 47:1255-1262. Hood, EE, Love, R, Bray, J, Lane, J, Clough, RC, Pappu, K Drees, C, Hood, KR, Yoon, S, Ahmad, A and

Howard, JA; 2007 Subcellular targeting is a key condition for high-level accumulation of cellulase protein in transgenic maize seed. Plant Biotechnology J; 5:709-719

Agrobacterium

Hood, E.E., G. Jen, L. Kayes, J. Kramer, R.T. Fraley, and M.-D. Chilton 1984 Restriction

endonuclease map of pTi Bo542, a potential Ti plasmid vector for genetic engineering of legumes. Bio/Technology 2:702-708

Chilton, W.S., E.E. Hood and M.-D. Chilton 1985 Absolute stereochemistry of leucinopine, a crown

gall opine. Phytochem. 24:221-224 Chilton, W.S., E.E. Hood, K.L. Rinehart, Jr., and M.-D. Chilton 1985 L,L-succinamopine: An epimeric

crown gall opine. Phytochem. 24:2945-2948 Hood, E.E., G.L. Helmer, R.T. Fraley and M.-D. Chilton 1986 The non-T-DNA portion of pTiBo542 is

responsible for the hypervirulence of Agrobacterium tumefaciens A281. J.Bacteriol. 168:1291-1301

http://www.cropscience.org.au/icsc2004/symposia/3/5/1955_hoode.htm

ELIZABETH E. HOOD, Ph.D. Hood, E.E., W.S. Chilton, M.-D. Chilton and R.T. Fraley 1986 T-DNA and opine synthetic loci in

tumors incited by Agrobacterium tumefaciens A281 on soybean and alfalfa plants. J. Bacteriol. 168:1283-1290

Hood, E.E., R.T. Fraley, and M.-D. Chilton 1987 Virulence of Agrobacterium tumefaciens strain A281

on legumes. Plant Physiol. 83:529-534 Hood, E.E., D.H. Clapham, I. Ekberg and T. Johansson 1990 T-DNA presence and opine production

in tumors of Picea abies (L.) Karst induced by Agrobacterium tumefaciens A281. Plant Mol. Biol. 14:111-117

Clapham, D., I. Ekberg, G. Eriksson, E.E. Hood, and L. Norell 1990 Within-population variation in

susceptibility to Agrobacterium tumefaciens A281 in Picea abies (L.) Karst. Theor. Appl. Genet. 79:654-656

Hood, E.E., S.B. Gelvin, L.S. Melchers, and A. Hoekema 1993 New Agrobacterium helper plasmids

for gene transfer to plants. Trans. Res. 2:208-218 Smith, R.H., and E.E. Hood 1994 Agrobacterium tumefaciens transformation of monocotyledons

Crop Science 35:301-309

Plant cell walls Hood, E.E., Q.X. Shen and J.E. Varner 1988 A developmentally regulated hydroxyproline-rich

glycoprotein in maize pericarp cell walls Plant Physiol. 87:138-142 Hood, E.E., K.R. Hood and S.E. Fritz 1991 Hydroxyproline-rich glycoproteins in cell walls of pericarp

from maize. Plant Science. 79:13-22 Fritz, S.E., K.R. Hood, and E.E. Hood 1991 Localization of soluble and insoluble fractions of

hydroxyproline-rich glycoproteins during maize kernel development. J. Cell Sci. 98:545-550 Hood, K.R., R.A. Baasiri, S.E. Fritz, and E.E. Hood 1991 Biochemical and tissue print analyses of

hydroxyproline-rich glycoproteins in cell walls of sporophytic maize tissues. Plant Physiol. 96:1214-1219

Murphy, J.M. and E.E. Hood 1993 Molecular basis of the size heterogeneity of extensin from two

maize vatieties. Plant Mol. Biol. 21:885-893 Hood, E.E., J.M. Murphy and R.C. Pendleton 1993 Molecular characterization of maize extensin

expression. Plant Mol. Biol. 23:685-695

Other Hood, E.E., S. Armour, J. Ownby, A. Handa, and R. Bressan 1979 Cyclic adenosine 3', 5'-

monoshosphate in Anabaena variabilis: Effects of nitrogen starvation Biochem Biophys. Acta 588:193-200

Ownby, J., M. Shannahan, and E.E. Hood 1979 Protein synthesis and degradation in Anabaena

during nitrogen starvation. J. of Gen Microbiol. 110:225-261 Lanoue, K.Z., P.G. Wolf, S. Browning and E.E. Hood 1996 Phylogenetic analysis of restriction site

variation in wild and cultivated Amaranthus species (Amaranthaceae). Theor. Appl. Genet. 93:722-732

Fitzgerald, M.S., E.V., Shakirov, E.E. Hood, T.D. McKnight and D.E. Shippen 2001 Different modes of de novo telomere formation by plant telomerase. Plant J. 26(1): 77-87

Hood, E.E. 2000 Riding the Waves. Science’s Next Wave June 2, 2000

ELIZABETH E. HOOD, Ph.D. Hood, E.E. “Selecting the Fruits of Your Labors” 2003. Trends in Plant Science. 8:357-358. Hood, E.E. “Where, Oh Where Has My Protein Gone?” 2004. Trends in Biotechnology 22:53-55.

BOOK

Hood, E.E. and J. Howard, Eds. Plants as Factories for Protein Production. 2002. Kluwer Academic Publishers, Dordrecht, The Netherlands. 209 pp.

BOOK CHAPTERS

Varner, J.E. and E.E. Hood. 1988. Gel properties of the cell wall. In: J.E. Varner, (ed),

Developmental Biology Series: Self assembling architecture. Alan R. Liss, Inc., New York. pp. 97-103.

Hood, E.E., K.R. Hood and S.E. Fritz. 1992. Localization of Extensin in Maize Cell Walls Using

Monoclonal Antibodies. In: P. Reid, R. Pont-Lezica, E. del Campillo and R. Taylor, eds., Tissue Printing, Tools for the Study of Anatomy, Histochemistry and Gene Expression. Academic Press, Inc., San Diego. pp. 32-35.

Hood, E.E., K. Lanoue, K.R. Hood, S.E. Fritz and R.A. Baasiri. 1994. Molecular Similarities among

Amaranthus Species. In: Biotechnology for Aridland Plants, T.J. Mabry, H. T. Nguyen, R. A. Dixon, and M.S. Bonness, eds. IC2 Institute, The University of Texas at Austin, Austin, TX.

Hood, E.E. 1996. Biochemical, immunological and molecular characterization of extensin. In: H.F.

Linskins and J.F. Jackson, eds., Modern Methods of Plant Analysis. Vol. 17: Plant Cell Wall Analysis. pp.117-128.

Hood, E.E., A. Kusnadi, Z. Nikolov and J.A. Howard. 1999. Molecular Farming of Industrial Proteins

from Transgenic Maize. In: P. Kolodziejczyk, Shahidi, et al eds., Chemicals via Higher Plant Bioengineering, Kluwer Academic/Plenum Publishers, N.Y.

Hood, E.E., 1999. Analysis of Plant Transformation Systems in "Application of transformation

technology in plant breeding". Published as Proceedings of the 30th Annual Symposium of the Korean Breeding Society, held in Suwon, Korea, November 18-21, 1999. pp. 33-38.

Hood, E.E. and Woodard, S. 2002. Industrial proteins produced from plants. In: Plants as Factories

for Protein Production. E.E. Hood and J. A. Howard, Eds., Kluwer Academic Publishers, Dordrecht, The Netherlands. pp. 119-135.

Hood, E.E., M.E. Horn and J.A. Howard. 2003. “Production and Application of Proteins from

Transgenic Plants" In: I. Vasil, Ed., Plant Biotechnology 2002 and Beyond, Proceedings of the 10th IAPTC&B Congress, Orlando, FL. Kluwer Academic Publishers, Dordrecht, The Netherlands. pp. 377-382.

Delaney, D., J. Jilka, D. Barker, P. Irwin, M. Poage, S. Woodard, M. Horn, A. Vinas, K. Beifuss, M.

Barker, B. Wiggins, C. Drees, R. Harkey, Z. Nikolov, E. Hood and J. Howard. 2003. “Production of aprotinin in transgenic maize seeds for the pharmaceutical and cell culture markets” In: I. Vasil, Ed., Plant Biotechnology 2002 and Beyond, Proceedings of the 10th IAPTC&B Congress, Orlando, FL. Kluwer Academic Publishers, Dordrecht, The Netherlands. pp. 393-394.

Hood, E.E., Plants as Enzyme Factories, In: Handbook of Plant Biotechnology Vol. 2; R. Fischer and

N. Emans, Eds., John Wiley & Sons Ltd., West Sussex, 2004. Hood, E.E. and J.A. Howard; 2008; “Over-expression of Novel Proteins in Maize” In: A. Kriz and B.

Larkins, Eds., Molecular Genetic Approaches to Maize Improvement Springer—Berlin, Heidelberg, Germany pp. 91-105


PATENTS 1. Commercial Production of Avidin in Plants—5,767,379: C. Baszczynski, E. Hood, S. Maddock, T.

Meyer, J. Register, D. Witcher, J. Howard. 2. Commercial Production of B-Glucuronidase in Plants—5,804,694: W. Bruce, E. Hood, D.

Peterson, J. Register, D. Witcher, J. Howard. 3. Commercial Production of Aprotinin in Plants — 5,824,870: C. Baszczynski, T. Czapla, E. Hood,

T. Meyer, D. Peterson, G. Rao, J. Register, D. Witcher, J. Howard. 4. Commercial Production of Proteases in Plants — 6,087,558: E. Hood, J. Howard. 5. Commercial Production of Laccase in Plants — 6,800,792: E. Hood, J. Howard, J. Jilka 6. Novel Plant Promoter Sequences and Methods of Use for Same—6,977,325: E. Hood, J. Jilka,

J. Howard. 6,977,325 7. Method of Increasing Recovery of Heterologous Active Enzymes Produced in Plants—6,632,930:

E. Hood, J. Howard, M. Bailey, F. van Gastel, H. Wang, M. Ward, S. Woodard. 8. Method of Increasing Heterologous Protein Expression in Plants—published: 20030145346 E.

Hood, J. Howard, D. Delaney. 9. Commercial production of recombinant manganese-dependent peroxidase in plants— 7,067,226

E. Hood, J. Howard, R. Clough, K. Pappu. 10. E. Hood and J. Howard; Commercial production of polysaccharide degrading enzymes in plants

and methods of using same published—20060026715 11. Methods for commercial production of heterologous laccase in plant tissue and extraction of the

laccase from plant seed—7,071,384; J. Howard, E. Hood, M. Bailey-Piatchek 12. Methods of commercial production and extraction of protein from seed—20030110537; J.

Howard, E. Hood, M. Piatchek 13. Methods for the cost effective saccharification of lignocellulosic biomass—20030109011; E.

Hood, J. Howard 14. Commercial production of polysaccharide degrading enzymes in plants and methods of using

same. Published—20060026715 E. Hood and J. Howard

INVITED PRESENTATIONS—International, Keynote

Hood, E.E. A comparison of transformation methods for plants, 30th Annual Symposium of the Korean Breeding Society, Suwon, Korea, Nov. 18-21, 1999

Hood, E.E. New century, new technology and new products. Plenary presentation - 6th

International Congress of Plant Molecular Biology, Québec, Canada, June 18-24, 2000 Hood, E.E. Plant Production Platforms for Industrial Applications; Plenary presentation;

Genome Alberta annual meeting. Banff, Canada, March 18-21, 2007

INVITED PRESENTATIONS—International

Hood, E.E., A. Kusnadi, Z. Nikolov and J.A. Howard. Molecular farming of industrial proteins from transgenic maize. Molecular Farming Conference, Saskatoon, Canada. October, 1997

Hood, E.E. The history and host range of Agrobacterium strains. Brassica Genetic

Technologies for the Future. Montreal Canada, October, 1998 Hood, E.E. Molecular farming of industrial proteins from transgenic maize. IX Pacific Science

Inter-Congress: Sustainable development in the Pacific. Taipei, Taiwan. November, 1998 Hood, E.E. A most a-maize-ing system, Advances in Plant Production Systems, International

Molecular Farming Conference, London, Ontario, Canada, Aug. 29-Sept. 1, 1999

ELIZABETH E. HOOD, Ph.D. Hood, E.E. The maize production system for edible vaccines and industrial enzymes. Intl.

Symposium of Plant Molecular Farming, Tsukuba, Japan, March 7-8, 2000. Hood, E.E. From green plants to industrial enzymes. Third International Symposium on

Industrial Proteins, Netherlands Congress Centre, The Hague, The Netherlands, March 15-16, 2001

Hood, E.E. New Century, New Technology and New Products. Crucell Holland BV. Leiden, The

Netherlands. March, 2001 Hood, E.E. New Century, New Technology and New Products. Nestle Research Center,

Laussane, Switzerland. March, 2001 Hood, E.E. New Century, New Technology and New Products. Syngenta BV. Leiden, The

Netherlands. March, 2001 Hood, E.E. Molecular farming in corn to produce industrial enzymes. High Value-Added

Proteins, Cambridge University, UK, July, 2002. Hood, E.E. Maximizing recombinant protein accumulation in corn. NIAS-COE International

Symposium "Protein Trafficking Mechanism and its Application to Molecular Farming" Tsukuba, Japan, November 11-12, 2003

Hood, E.E. Bioindustrial and Biopharmaceutical Products from Transgenic Plants 4th

International Crop Science Congress, Brisbane Australia, Sept. 26-October 1, 2004

INVITED PRESENTATIONS —National, Keynote Hood, E.E. Maize production system for edible vaccines & industrial enzymes, Keynote

speaker at the Annual Meeting of the Arkansas Biotechnology Association, Little Rock, Arkansas, September 15, 1999.

INVITED PRESENTATIONS - National

Hood, E.E. Molecular similarities among Amaranthus species. Applications and Prospects of

Biotechnology for Arid and Semi-arid Lands., Texas Tech University, 1992 Hood, E.E. Commercial production of avidin from transgenic maize. Dept. of Biochem. and

Biophysics, Texas A&M University. March, 1997 Hood, E.E. and J.A. Howard. Transgenic corn: A new source of valuable industrial products.

Corn Utilization and Technology Conference. St. Louis, MO June, 1998 Hood, E.E. Production of industrial proteins from transgenic maize. Dept. of Plant Pathology,

Texas A&M University. September, 1998 Hood, E.E. and J.A. Howard. Commercial production of industrial proteins from transgenic

corn, 90th AOCS Annual Meeting & Expo, Marriott’s Orlando World Center, Orlando, Florida, May 9-12, 1999

Hood, E.E. Novel uses of agricultural crops through biotechnology, Texas State Extension

Conference, Texas A&M University, College Station, TX, July 14-16, 1999 Hood, E.E. The maize production system for edible vaccines and industrial enzymes.

219th ACS National Meeting, March 26-30, 2000 Hood, E.E. New century, new technology and new products. Horticulture and Landscape

Architecture Seminar, Purdue University, West Lafayette, Indiana, September 21, 2000

ELIZABETH E. HOOD, Ph.D. Hood, E.E. New century, new technology and new products. IBC's Agricultural Genomics, Coral

Gables, Florida, December 6-8, 2000 Hood, E.E. Maize as a production system for biopharmaceuticals and industrial enzymes.

Workshop presentation. IBC’s Agricultural Genomics, Coral Gables, Florida, December 6-8, 2000

Hood, E.E. Riding the Waves. WISE Conference at TAMU (Achieving your vision), College Station,

Texas, February 17, 2001 Hood, E.E. Functional products from transgenic plants PITTCON 2002, New Orleans, Louisiana,

March 2002 Hood, E.E. Challenges for commercialization of products from a new technology—

pharmaceuticals, vaccines and industrial enzymes from transgenic maize USPTO Tech Fair, Washington, D.C., August 2002

Hood, E.E. Molecular Farming in Corn to Produce Industrial Enzymes. Bioengineering group,

Iowa State University, Ames, Iowa, Sept. 18, 2002 Hood, E.E. Enzymes from the Transgenic Maize Production System—Advantages for

producers Iowa Biotechnology Association Annual Meeting Sept. 19, 2002 Hood, E.E. Enzymes from the Transgenic Maize Production System Iowa Quality Producer’s

Association Annual Meeting March 28, 2003 Hood, E.E. Transgenic plant-produced cellulases for biomass conversion SIVB Society for In

Vitro Biology Portland, OR June 4, 2003 Hood, E.E. Production and Application of Proteins from Transgenic Plants Ohio State

University, Dept. of Plant molecular and cellular biology, May, 2004 Hood, E.E. Commercialization of a Protein Product from Transgenic Maize 17th National Agricultural

Biotechnology Council, Nashville, TN, June 27-29, 2005 Hood, E.E. Bioethanol as a Sustainable Energy Alternative, for the Memphis BioWorks Development

Council series luncheon at the University of Memphis, Memphis TN. July 26, 2006 Hood, E.E. Plant Production Platforms for Industrial Applications; MAESC, Oxford, MS May 17-

18, 2007 Hood, E.E. Cellulase Enzymes from the transgenic maize production system; Syngenta invited

seminar, Raleigh, NC, January 15, 2008 Hood, E.E. Process for Commercialization of Products from Transgenic Plants; LSU invited

seminar, Baton Rouge, LA, April 8, 2008 Hood, E.E., JA Howard, R Jimenez-Flores, G McChesney Maize-Produced Cellulases Degrade

Lignocellulosic Feedstocks; BIO World Congress for Industrial Biotechnology and Bioprocessing, Chicago, IL April 28-30, 2008

Hood, E.E. "Cellulase enzymes for biomass conversion from the transgenic maize production

system; Worcester Polytechnic Institute conference: Growing Fuel and Medicine: Advancing Biofuels and Plant-Produced Therapeutics; Worcester, MA, October 27, 2008

Hood, E.E.”New Applications of Plants—Bio-Factories for Bio-Based Products”; Planting Seeds for

the Future--New Crops Conference; November 13, 2008 Hood, E.E. “Biomass-based ethanol and renewable resources for the Bio-Economy”; North Delta

AgExpo, Arkansas Farm Bureau; February 5, 2009


OTHER RELEVANT ABSTRACTS Murphy, J.M. and E.E. Hood. 1991. Protein size heterogeneity of cell wall extensin protein in 2

maize varieties. American Society of Plant Physiologists Annual Meeting, Albuquerque, New Mexico

Hood, E.E. and R.A. Baasiri. 1991. Similarity among 24 breeding lines of grain amaranth based

on leaf and seed protein heterogeneity. American Society of Plant Physiologists Annual Meeting, Albuquerque, New Mexico

Hood, E.E., K.R. Hood, W. McManus and J.M. Murphy. 1991. Position and regulation of

extensin in the structure of maize pericarp. International Conference of Plant Molecular Biology, Tuscon, Arizona

Hood, E.E., J.M. Murphy and R.C. Pendleton. 1992. Cell and molecular biology of maize

extensin. VIth International Conference on Plant Cell Walls, Nijmegen, The Netherlands Hood, E.E., J.M. Murphy and R.C. Pendleton. 1993. Molecular characterization of maize

extensin expression. Keystone Symposium on Cell Wall Structure and Function, Santa Fe. New Mexico

Hood, E.E. and S.B. Gelvin. 1993. EHA105, A Versatile Ti Helper Plasmid Useful in

Transformation of a Wide Variety of Plants. Plant Cell and Tissue Culture Gordon Conference, Wolfeboro, New Hampshire

Lanoue, K.Z. and E.E. Hood. 1994. Phylogenetic relationships in the genus Amaranthus by

restriction site analysis. American Society of Plant Physiologists Annual Meeting, Portland, OR

Hood, E.E., H.G. Levine, K.Z. Lanoue and D.L. Bishop. 1995. Wheat cell wall structure in

microgravity: Chromex-06, STS-63. I. Plant growth parameters, morphology and carbohydrate analysis. ASGSB Annual Meeting, Washington, D.C.

Bishop, D.L., W. McManus, H.G. Levine, A.J. Anderson and E.E. Hood. 1995. Wheat cell wall

structure in microgravity: Chromex-06, STS-63. II. Lignin and hydrogen peroxide accumulation, calcium localization and cell wall ultrastructure. ASGSB Annual Meeting, Washington D.C.

Hood, E.E., A. Singh-Cundy, K.Z. Lanoue and D.L. Bishop. 1995. Wheat cell wall structure in

microgravity: Chromex-06, STS-63. III. Peroxidase activity and isozymes and cell wall extensibility. ASGSB Annual Meeting, Washington D.C.

Hood, E.E., D.R. Witcher, B. Kappel, C. Wooge, S. Maddock and J.A. Howard. 1996. Commercial

production of avidin from transgenic maize. SIVB Annual Meeting, San Francisco, CA. Hood, E.E., D.R. Witcher, M. Bailey, Z. Nikolov, A. Kusnadi, D. Peterson and J.A. Howard. 1997.

Commercial production of β -glucuronidase from transgenic maize. SIVB Annual Meeting, Washington D.C.

Hood, E.E. 2005 Bio-industrial Products from Genetically Engineered Plants The World

Congress on Industrial Biotechnology and Bioprocessing, Orlando FL Hood, E.E. 2005 Production of enzymes in transgenic maize for industrial applications

American Society of Plant Biologists, Annual Meeting, Seattle, WA Hood, E.E.and J.A. Howard 2007 Cellulases from the transgenic maize production system;

World Congress on Industrial Biotechnology and Bioprocessing; Orlando FL March 21-24, 2007

ELIZABETH E. HOOD ARKANSAS STATE UNIVERSITY

CURRENT AND PENDING SUPPORT Support: Current Project/Proposal Title: Delta Center for Identity Solutions--ASU; PI--Hood; co-PI--Moeeni Source of Support: AR Science and Technology Authority Total Award Amount: $150,000 Total Award Period Covered:10/1/06-6/30-09 Location of Project: Jonesboro, AR and other state locations Person-Months Per Year Committed to the Project: 0.5 Support: Current Project/Proposal Title: Ethanol from Agriculture for Arkansas and America Source of Support: Dept. of Energy, Walton Family Foundation and Walmart Foundation Total Award Amount: $1,845,000 Total Award Period Covered: 7/1/08-12/31/09 Location of Project: Jonesboro, AR; San Luis Obispo, CA; College Station, TX Person-Months Per Year Committed to the Project: 5 Support: Current Project/Proposal Title: Determination of Factors Affecting High-Level Protein Accumulation in corn Source of Support: P3 subaward--NSF Total Award Amount: $150,000 Total Award Period Covered: 4/1/09-4/30/10 Location of Project: Jonesboro, AR Person-Months Per Year Committed to the Project: 1 Support: Current Project/Proposal Title: Crop Deregulation with Software: a Prototype Source of Support: P3 subaward—NSF D. Berlean, PI, E. Hood and R. Segall, co-PIs Total Award Amount: $91,571 Total Award Period Covered: 5/1/09-5/31/2010 Location of Project: Jonesboro, AR and other state locations Person-Months Per Year Committed to the Project: 0.5 Support: Pending Project/Proposal Title: Expansin Synergy with Cellulases for Biomass Conversion Source of Support: Consortium for Plant Biotechnology Research Total Award Amount: $94,500 Total Award Period Covered: 1/1/09-12/31/09 Location of Project: Jonesboro, AR Person-Months Per Year Committed to the Project: 1

Xiuzhen Huang Assistant Professor

Computer Science Department Arkansas State University

P.O.Box 9, State University, AR 72467 Phone: 870-972-3978 Fax: 870-972-3950

[email protected]

Education PhD in Computer Science, Texas A&M University, College Station, TX, 2004. MS in Computer Engineering, Shandong University, China, 1999. BS in Computer Science (with honor), Shandong University, China, 1996. Employment 2004 – Current Assistant Professor, Computer Science Department,

Arkansas State University, Jonesboro, AR 2001 – 2004 Research/Teaching Assistant, Department of Computer Science

and Engineering, Texas A&M University, College Station, TX 1999 – 2000 Lecturer, Computer Science Department, Shandong University of

Finance, China Joint Appointment Graduate Faculty of the Arkansas Bioscience Institute (ABI) Molecular Biosciences PhD Program, Arkansas State University, Jonesboro, AR Adjunct Faculty of Information Science Department, University of Arkansas at

Little Rock (UALR), Little Rock, AR Graduate Faculty of University of Arkansas for Medical Sciences (UAMS) and

University of Arkansas at Little Rock (UALR) Joint PhD Program in Bioinformatics, Little Rock, AR

Academic Award Dean’s Distinguished Faculty Achievement Award for Scholarship, College of Sciences and Mathematics, Arkansas State University, 2007 Research Interests

Bioinformatics and Computational Biology Algorithm Analysis and Design

Main Funds and Grants

PI: X. Huang (Co-PIs: C. Cramer, S. Jennings), Efficient Algorithms for Protein Structure Prediction and Applications in RTB Binding Occupancy Determination, Supported by NSF ESPCoR P3, $229,791, 2008-2010.

Co-PI: X. Huang (PI: E. Hood), Determination of Factors Affecting High-Level Protein Accumulation in Transgenic Maize Seed, Supported by NSF ESPCoR P3, $150,000, 2009-2010.

Co-PI: X. Huang (PI: H. Wang, Other Co-PIs: S. Grace, N. Ali), Metabolomic and Genomics Empowered Platform for Phytochemical and Gene Network Discovery in Medicago Truncatula, Supported by NSF ESPCoR P3, $222,584, 2008-2010.

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PI: X. Huang, NSF ESPCoR equipment funds for the Bioinformatics Lab at Arkansas Biosciences Institute (ABI) of Arkansas State University, $30,000, 2008-2009.

PI: X. Huang, College Support for Molecular Biosciences (MBS) Techniques Modules in Bioinformatics, College of Sciences and Mathematics, Arkansas State University, $7,000, 2008.

PI: X. Huang, NIH grant from IDeA Network of Biological Research Excellence (INBRE) Summer Research Fellowship, Efficient Algorithms for RNA/Protein Structure Prediction, $21,063 (including $2,500 Research Support, College of Sciences and Mathematics, Arkansas State University), 2007.

PI: X. Huang, NIH grant from IDeA Network of Biological Research Excellence (INBRE) Summer Research Fellowship, Efficient Algorithms for Protein Tertiary Structure Prediction, $18,563, 2006.

Current Research Assistant Students One PhD student in Molecular Biosciences at Arkansas State University One PhD student in Bioinformatics at University of Arkansas at Little Rock One Master student in Computer Science at Arkansas State University One Undergraduate in Computer Science at Arkansas State University

Selected Peer-reviewed Journal Publications (2004-current) Parameterized complexity and biopolymer sequence comparison, L. Cai, X.

Huang, C. Liu, F. A. Rosamond, and Y. Song, The Computer Journal 51, 2008.

Fixed-parameter approximation: conceptual framework and approximability results, L. Cai and X. Huang, Algorithmica, 2008.

A practical comparison of two K-means clustering algorithms, G. A. Wilkin and X. Huang, BMC Bioinformatics 9(Suppl 6), 2008.

Protein tertiary structure prediction by protein threading: a survey, X. Huang, L. Cai, and E. Hood, to appear in Plant Biotechnology Journal, 2008.

Maximum common subgraph: some upper bound and lower bound results, X. Huang and J. Lai, Steven Jennings, BMC Bioinformatics 7(Suppl 4), 2006.

Efficient parameterized algorithms for biopolymer structure-sequence alignment, Y. Song, C. Liu, X. Huang, R. L. Malmberg, Y. Xu, and L. Cai, IEEE/ACM Transactions on Computational Biology and Bioinformatics 3: 423-432, 2006.

Polynomial time approximation schemes and parameterized complexity, J. Chen, X. Huang, I. A. Kanj, G.Xia, Discrete Applied Mathematics 155: 180-193, 2007.

Strong computational lower bounds via parameterized complexity, J. Chen, X. Huang, I. A. Kanj, G. Xia, Journal of Computer and System Sciences 72: 1346-1367, 2006.

On the computational hardness based on linear FPT-reductions, J. Chen, X. Huang, I. A. Kanj, G. Xia, Journal of Combinatorial Optimization 11: 231-247, 2006.

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Tight lower bounds for certain parameterized NP-hard problems, J. Chen, B. Chor, M. Fellows, X. Huang, D. W. Juedes, I. A. Kanj, G. Xia, Information and Computation 201: 216-231, 2005.

Selected Peer-reviewed Conference Publications (2004-current) A relational approach for pathway analysis, C. Ashby, X. Huang, J. Jenness

and J. Kerby, Proceedings of Symposium of Computations in Bioinformatics and Bioscience, IEEE Computer Society, Shanghai, 2008.

Addressing bio-sequence and bio-structure problems, X. Huang, Proceedings of Symposium of Computations in Bioinformatics and Bioscience, IEEE Computer Society, Shanghai, 2008.

K-means clustering algorithms: implementation and comparison , G. A. Wilkin and X. Huang, Proceedings of Symposium of Computations in Bioinformatics and Bioscience, IEEE Computer Society, Iowa, 2007.

Parameterized graph problems in computational biology, X. Huang and J. Lai, Proceedings of Symposium of Computations in Bioinformatics and Bioscience, IEEE Computer Society, Iowa, 2007.

Fixed-parameter approximation: conceptual framework and approximability results, L. Cai and X. Huang, Proceedings of the International Workshop on Parameterized and Exact Computation (IWPEC’06), Lecture Notes in Computer Science 4169, pp. 96-108, Zurich, Switzerland, 2006.

Parameterized computation of LCS for two sequences, Y. Lin, J. Jenness, and X. Huang, Proceedings of the International Conference on Bioinformatics and Computational Biology, Las Vegas, Nevada, 2006.

Lower bounds and parameterized approach for longest common subsequence, X. Huang, Proceedings of the 12th Annual International Computing and Combinatorics Conference (COCOON’06), Lecture Notes in Computer Science 4112, pp. 136-145, Taipei, Taiwan, 2006.

Negative-weight cycle algorithms, X. Huang, Proceedings of the 2006 Proceedings of International Conference on Foundations of Computer Science (FCS’06), 2006.

On PTAS for planar graph problems, X. Huang and J. Chen, Proceedings of the 4th IFIP International Conference on Theoretical Computer Science, published by Springer Science and Business Media, pp. 299-314, Santiago, Chile, 2006.

Structural study on proteins in maize silk, X. Huang, Proceedings of the 4th World Congress of Computers in Agriculture, pp. 803-806, Orlando, FL, 2006.

Maximum common subgraph: upper bound and lower bound results, X. Huang and J. Lai, Proceedings of Symposium of Computations in Bioinformatics and Bioscience, IEEE Computer Society, pp. 40-47, Hangzhou, China, 2006.

Linear FPT-reductions: structural properties and applications, J. Chen, X. Huang, I. A. Kanj, G. Xia, Proceedings of the 11th Annual International Computing and Combinatorics Conference, Lecture Notes in Computer Science 3153, pp. 500-512, Kunming, China, 2005.

Efficient parameterized algorithm for biopolymer structure-sequence alignment, Y. Song, C. Liu, X. Huang, R. L. Malmberg, Y. Xu, L. Cai,

3

Tight lower bounds for certain parameterized NP-hard problems, J. Chen, B. Chor, M. Fellows, X. Huang, D.W. Juedes, I. A. Kanj, G.Xia, Proceedings of the 19th IEEE Conference on Computational Complexity (CCC’04), pp. 150-160, Amherst, MA, 2004.

Polynomial time approximation schemes and parameterized complexity, J. Chen, X. Huang, I. A. Kanj, G. Xia, Proceedings of the 29th International Symposium on Mathematical Foundations of Computer Science (MFCS’04), Lecture Notes in Computer Science 3153, pp. 500-512, Prague, Czech Republic, Europe, 2004.

Linear FPT reductions and computational lower bounds, J. Chen, X. Huang, I. A. Kanj, G. Xia, Proceedings of the 36th ACM Symposium on Theory of Computing (STOC’04), pp. 212-221, Chicago, IL, 2004.

Invited Talks and Presentations (2005-current): Addressing bio-sequence and bio-structure problems, at Symposium of

Computations in Bioinformatics and Bioscience, Shanghai, China, 2008. Efficient algorithms for protein structure prediction and applications in

RTB binding occupancy determination, NSF EPSCoR Annual Meeting, Little Rock, Arkansas, 2008.

Algorithms for protein structure prediction and applications in RTB, at Arkansas Biosciences Institute of Arkansas State University, Arkansas, 2008.

Microarray data analysis in bioinformatics, at Arkansas Biosciences Institute of Arkansas State University, Arkansas, 2007.

Efficient parameterized algorithms for structure-sequence alignment, at University of Arkansas for Medical Sciences, Little Rock, AR, 2007.

Parameterized computational lower bounds and some applications in bioinformatics, at University of Georgia, Athens, Georgia, 2007.

Efficient algorithms for protein tertiary structure prediction, at University of Arkansas for Medical Sciences, Little Rock, Arkansas, 2006.

Structure-sequence alignment, at University of Arkansas at Fayetteville, Fayetteville, Arkansas, 2006.

Fixed-parameter approximation: conceptual framework and approximability results, at the International Workshop on Parameterized and Exact Computation, Zurich, Switzerland, 2006.

Structural study on proteins in maize silk, at the 4th World Congress of Computers in Agriculture, Orlando, Florida, 2006.

Parameterized computation in bioinformatics, at Arkansas Biosciences Institute of Arkansas State University, Jonesboro, Arkansas, 2005.

Linear FPT-reductions: structural properties and applications, at Annual International Computing and Combinatorics Conference, China, 2005.

Parameterized computation and bioinformatics, at School of Computer Science and Technology, Shandong University, China, 2005.

Vertex cover and clique - a flavor of bioinformatics, at School of Computer Information and Engineering, Shandong University of Finance, China, 2005.

Finding maximum common subgraph, at Combinatorics in the South-Central U.S. Annual Conference, San Marcos, Texas, 2005.

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5

Professional Societies, Awards and Recognition Member of International Society for Computational Biology (ISCB) Member of Association for Computing Machinery (ACM) and ACM Special

Interest Group on Algorithms and Computation Theory (ACM SIGACT) Member of Society of Women Engineers (SWE) Member of Society for Industrial and Applied Mathematics (SIAM) NSF travel award to attend CRA-W Career Mentoring Workshop & STOC’03 SIGACT travel award to attend STOC’04 Invited speaker, participant, Dagstuhl Seminar on Parameterized complexity

and approximation algorithms in Germany

RONALD L. JOHNSON PROFESSOR OF ZOOLOGY

ACADEMIC TRAINING

BS Calif. State Univ., Long Beach 1977 Marine Biology MA University of Northern Colorado 1981 Biology DA University of Northern Colorado 1985 Biology

PROFESSIONAL EXPERIENCE

Assistant Professor of Biology Sterling College 1981-1985 Associate Professor of Biology Springfield College 1985-1992 Assistant Professor of Biology Arkansas State Univ. 1992-1998 Associate Professor of Biology Arkansas State Univ. 1998-2002 Professor of Biology Arkansas State Univ. 2002-Present Interim Chair of Biology Arkansas State Univ. 2002-2003 Assistant Chair of Biology Arkansas State Univ. 2003-Present

SCHOLARLY PUBLICATIONS B. Kaimal, R.L. Johnson, and R. Hannigan. 2009. Distinguishing breeding populations of mallards (Anas platyrhynchos) using trace elements. Journal of Geochemical Exploration (in press). R.L. Johnson, A.D. Christian, S.D. Henry and S.W. Barkley. 2009. Distribution and ecology of black basses (Micropterus) in the lower Eleven Point River, Arkansas. Southeastern Naturalist (in press). R.L. Johnson and T. Kennon. 2008. Teaching population genetics and evolution in the biology classroom using Drosophila. American Biology Teacher (In press). M.S. Wine, M. Weston and R.L. Johnson. 2008. Population dynamics and ecology of a species of darter endemic to Arkansas. Southeastern Naturalist 7:665-678. S.D. Henry, S.W. Barkley, J.B. Koppelman and R.L. Johnson. 2008. Assessment of stocking success of walleye (Sander vitreus) in the Eleven Point River, Arkansas. North American Journal of Fisheries Management 28:1498-1505. J B. Trauth, R.L. Johnson, and S. E. Trauth. 2007. Conservation implications of a morphometric comparison between the Illinois chorus frog (Pseudacris streckeri illinoensis) and Strecker=s chorus frog (P. s. streckeri) (Anura: Hylidae) from Arkansas, Illinois, Missouri, Oklahoma, and Texas. Zootaxa 1589:23-32. M.R. Weston and R.L. Johnson. 2007. Visible implant elastomer as a tool for marking Etheostomine darters (Actinopterygii: Percidae). Southeastern Naturalist 7:159-164.

R. L. Johnson, S.M. Coghlan and T. Harmon. 2007. Spatial and temporal variation in prey selection of brown trout in a cold Arkansas tailwater. Ecology of Freshwater Fish 16:373-384. R. L. Johnson, S. C. Blumenshine S. M. Coghlan. 2006. A bioenergetic analysis of factors limiting brown trout growth in an Ozark tailwater river. Environmental Biology of Fishes 77:121-132. R.L. Johnson, R.M. Mitchell, and G.L. Harp. 2006. Genetic variation and genetic structuring of a numerically declining species of darter, Etheostoma moorei Raney & Suttkus, endemic to the Upper Little Red River, Arkansas. American Midland Naturalist 156:37-44. J. B. Trauth, S. E. Trauth, and R. L. Johnson. 2005. Best management practices and drought combine to silence the Illinois Chorus Frog in Arkansas. Wildlife Society Bulletin 34:514-518. S.D. Henry, S.W. Barkley and R.L. Johnson. 2005. Exploitation of Nile Tilapia in a closed system, public fishing reservoir in northern Arkansas. North American Journal of Fisheries Management 25:853-860. R. L. Johnson and G. L. Harp. 2005. Spatio-temporal changes of benthic macroinvertebrates in a cold Arkansas tailwater. Hydrobiologia 537:15-24.

R.L. Johnson and T. Fulton. 2004. Incidence of Florida largemouth alleles in two northern Arkansas populations of largemouth bass, Micropterus salmoides Lacepede. American Midland Naturalist 152:425-429. A. Sako, C.M. O=Reilly, R. Hannigan, N. Bickford and R.L. Johnson. 2005. Variations in otolith elemental compositions of two clupeid species, Stolothrissa tanganicae and Limnotrhrissa miodon in Lake Tanganyika. Geochemistry: Exploration, Environment, Analysis 5:91-97. R.L. Johnson and K. A. Williams (ASU undergraduate). 2003. Genetic relationships of some common Arkansas freshwater sunfishes (Centrarchidae: Lepomis) inferred from restriction endonuclease analysis of mitochondrial DNA. Arkansas Academy of Sciences 57:95-99. R.L. Johnson and C. F. Cavenaugh (ASU undergraduate). 2003. Genetic similarity of shadow and Ozark basses (Ambloplites) as determined by mitochondrial DNA analysis. Arkansas Academy of Sciences 57:204-208. Johnson, R.L., J. Magee and T. A. Hodge. 2002. Phylogenetics of freshwater black basses (Centrarchidae: Micropterus) inferred from restriction endonuclease analysis of mitochondrial DNA. Biochemical Genetics 39:396-406.

Mitchell, R.M., R.L. Johnson and G.L. Harp. 2002. Population structure of an endemic species of yellowcheek darter, Etheostoma moorei (Raney and Suttkus), of the upper Little Red River, Arkansas. American Midland Naturalist 148:129-137.

Johnson, R.L. and R.S. Staley. 2001. Identification of Florida largemouth bass alleles in Arkansas public and private aquaculture ponds. Arkansas Academy of Sciences 55:82-85.

Johnson, R.L., D. Ward and R. S. Grippo. 2000. Physicochemical and macroinvertebrate assemblages of riffles upstream and downstream of a streambank impacted by unrestricted cattle access. Arkansas Academy of Sciences 54:68-76. Johnson, R.L. and W.T. Fulton. 1999. Persistence of Florida largemouth bass alleles in a northern Arkansas population of largemouth bass. Ecology of Freshwater Fish 8:35-42. Johnson, R.L., F.Q. Liang and J.L. Farris. 1999. Genetic relationships of several Amblemini species (Bivalvia: Unionidae) in Arkansas. Journal of Shellfish Research 17: 1237-1242. Johnson, R.L., F.Q. Liang, C.D. Milam and J.L. Farris. 1999. Genetic diversity and cellulolytic activity among several species of Unionid bivalves in Arkansas. Journal of Shellfish Research 17:(5):1375-1382. Johnson, R.L., F.Q. Liang, and J.L. Farris. 1998. Genetic diversity among four Amblemini species (Bivalvia: Unionidae) in the Cache and White rivers, Arkansas. Southwestern Naturalist 43(3):321-332. Johnson, R.L. and R.M. Davis. 1997. Age, growth and condition of largemouth bass, Micropterus salmoides, of Lake Ashbaugh, Arkansas. Arkansas Academy of Sciences 51:95-102. Johnson, R.L. 1997. Science and criminal investigation. Science Scope 21(3):22-25. Johnson, R.L. and J. Pignatare. 1994. Restriction fragment length polymorphisms in the largemouth bass, Micropterus salmoides salmoides, in a small Massachusetts kettlehole. American Midland Naturalist 133:364-367. Johnson, R.L. 1994. The puzzle of man's past: An exercise for introducing evolution of the human species. Journal of College Science Teaching 25(2):111-113. Johnson, R.L. 1993. Directed student research at the undergraduate level. Journal of College Science Teaching. March/April 1993. Johnson, R.L. and E.E. Peeples. 1987. The role of scientific understanding in college

student acceptance of evolution. American Biology Teacher 49(2):93-98. GRANTS FUNDED: Arkansas Game and Fish Commission. Genetic analysis of Florida and largemouth basses of southern Arkansas lakes using microsatellites. 8/1/08-present. $12,766. ASU Faculty Research Grant. Relationship of gene flow to geographic distance in two species of polychaetes with different dispersal capabilities. 8/1/08-present. $6,000. Arkansas Game and Fish Commission. Genetic analysis of Florida and largemouth basses of southern Arkansas lakes using microsatellites. 6/1/07-7/31/08. $25,200. Completed. Arkansas Game and Fish Commission. Gene flow and genetic structuring of yellowcheek darters (Etheostoma moorei) in the Little Red River watershed. Completed. $5,665. SURF/SILO Arkansas Department of Higher Education. Introduction of Florida largemouth bass in an Arkansas population of northern largemouth bass and the performance of bass with those alleles. Co-PI. 12/31/06-12/31/07. $3,900. Beckman Coulter Corp. Genomics educational grant- Beckman DNA sequencer. Co-PI. $65,100. 2005. Arkansas Game and Fish Commission. Genetic and Morphologic Diversity and Relatedness in and Among Populations of Illinois Chorus Frogs (Pseudacris streckeri illinoensis) and Strecker=s Chorus Frogs (P. s. streckeri) in Arkansas. Co-PI. Completed. $65,994. Arkansas Department of Higher Education. Introducing molecular biology into the secondary classroom. Co-author. Completed. $44,479. US Fish and Wildlife Service. Migration of yellowcheek darters (Etheostoma moorei) in the Little Red River watershed. Completed. $17,000. US Fish and Wildlife Service. Gene flow and genetic structuring of yellowcheek darters (Etheostoma moorei) in the Little Red River watershed. Completed. $5,000. Arkansas Game and Fish Commission. A bioenergetic and food web analysis of factors limiting brown trout growth in the Little Red River, AR tailwaters: Potential for management options? Co-author. Completed. $2,500. Arkansas Game and Fish Commission. Species limits and phylogeography of Lampsilinae (Bivalvia: Unionidae) in Arkansas with emphasis on species of Lampsilis. Co-author. Completed. $58,935.

SILO Undergraduate Research Fellowship. Genetic relationships of the rock basses (Ambloplites) as determined by mitochondrial DNA analysis. Co-author. Completed. $3,751. SILO Undergraduate Research Fellowship. Genetic relationships of several species of Lepomis as determined by mitochondrial DNA analysis. 12/00-8/01; $3,592. Completed. ASU Faculty Research Grant. Relationship of gene flow to geographic distance in two species of polychaetes with different dispersal capabilities. 8/1/00-7/31/01. $8,200. Completed. Arkansas Game and Fish Commission. A survey of the macroinvertebrates and brown trout feeding habits within the Little Red River. 9/99-6/01.; $10,764. Completed. Arkansas Soil and Water Conservation Commission. Demonstration of streambank restoration on the Southfork of the Spring River, Arkansas. 1/1/98-5/02. $60,000. Completed. ASU Faculty Research Grant. Genetic and meristic variation between and within populations of Etheostoma moorei, the yellowcheek darter. Coauthor. 12/1/97-present. $2,500. Completed. SILO Undergraduate Research Fellowship. Genetic distance for the blue and channel catfishes (Genus: Ictalurus) as determined by mitochondrial DNA analysis. 12/1/97- 5/30/99. $3,100. Completed. Arkansas Science and Technology Authority. Genetic distance of and evolution of the Micropterid basses as determined by mitochondrial DNA analysis. 5/96-9/97; $35,406. Completed. ASU Faculty Research Grant. Genetic distance of and evolution of the Micropterid basses as determined by mitochondrial DNA analysis. 8/96-9/97. $6,340. Completed.

Arkansas Game and Fish Commission. Genotype, growth, condition and health of largemouth bass in Lakes Ashbaugh and SWEPCO, Arkansas. 10/95-4/96; $1,350. Completed. Arkansas Department of Higher Education: The Dwight D. Eisenhower Mathematics and Science Education Act. A summer training program for secondary teachers in molecular biology and biotechnology. Summers 1995-1996; $16,923. Completed. SILO Undergraduate Research Fellowship. Restriction fragment length polymorphism of mitochondrial DNA in the smallmouth bass, Micropterus dolomieu. 11/94-10/95; $2,677. Completed.

SILO Undergraduate Research Fellowship. Detection of interspecific DNA sequence variation in the mitochondrial cytochrome B gene of the Micropterid basses. 11/93-10/94; $2,794. Completed. ASU Faculty Research Grant. Allozyme analysis of freshwater mussels: Modeling of genotypic diversity in aquatic ecosystems. Coauthor. Fall 1993; $10,664. Completed. Southwestern Bell Minority Internship Program in Science and Mathematics- Molecular Biology Applications in Field Biology. Coauthor. 2 yrs, Summers 1993-1994; $100,000 Renewed 1995-1996; $100,000. Completed. PRESENTATIONS TO LEARNED FORUMS C. Cato, R. Allen, and R.L. Johnson. 2009. Genetic structure of largemouth bass (Micropterus salmoides) populations in several Arkansas lakes following the stocking of Florida bass (Micropterus floridanus): insight to the extent and effects of hybridization. American Fisheries Society, Arkansas Chapter, February 6; Bentonville, ARTunica. G. Harp, R. Mitchell, M. Wine, S. Blumenshine, M. Weston and R.L Johnson. 2008. Ecology and genetic structure of the darter Etheostoma moorei of the upper Little Red River, Arkansas. Arkansas Wildlife Action Conference, September 4, Mt. Magazine, Arkansas. J. Trauth, S.E. Trauth and R.L. Johnson. 2008. Diversity and relatedness of Illinois Chorus Frogs (Pseudacris streckeri illinoensis) and Strecker’s Chorus Frogs (P. s. streckeri). Arkansas Wildlife Action Conference, September 5, Mt. Magazine, Arkansas. Allen, R., C. Cato, R.L. Johnson, and A.D. Christianson. 2008. Genetic structure of largemouth bass (Micropterus salmoides) populations in several Arkansas lakes following the stocking of Florida bass (Micropterus floridanus): insight to the extent and effects of hybridization. American Fisheries Society, Southern Division, February 29; Wheeling, West Virginia.

Allen, R., C. Cato, R.L. Johnson, and A.D. Christian. 2008. Genetic structure of largemouth bass (Micropterus salmoides) populations in several Arkansas lakes following the stocking of Florida bass (Micropterus floridanus): insight to the extent and effects of hybridization. American Fisheries Society, Arkansas Chapter, February 21; Tunica. R.L. Johnson and N.T. Stephens. 2007. Genetic analysis of yellowcheek darter populations using AFLPs. American Fisheries Society, Southern Division, February 10; Memphis. Stephens, N.T. and R. L. Johnson. 2005. High resolution analysis of yellowcheek darter population structure using AFLPs. Joint Meeting of Herpetologists and

Ichthyologists. July 10; Tampa, FL. Poster. Henry, S.D., S.W. Barkley and R.L. Johnson. 2005. Exploitation of Nile tilapia in a closed system, public fishing reservoir in northern Arkansas. American Fisheries Society, September 11; Anchorage, AL. Poster. Henry, S.D., S.W. Barkley and R.L. Johnson. 2004. Exploitation of Nile tilapia in a closed system, public fishing reservoir in northern Arkansas. Southeastern Association of Fish and Wildlife Agencies. November 1; Hilton Head, SC. Poster. Blumenshine, S and R.L. Johnson. 2004. Factors affecting growth rates in Little Red River brown trout and potential benefits of forage base enhancement. North American Benthological Society. June 8; Vancouver, British Columbia. Sanders, T.N. and R.L. Johnson. 2004. Phylogenetic systematics of certain Lampsilis species in Arkansas as determined by amplified fragment length polymorphisms. Joint meeting of Freshwater Mollusk Conservation Society and U.S. Fish and Wildlife Service; June 29-30; Shepherdstown, WV. Poster. Trauth, J.B., M.L. McCallum, S.E. Trauth and R.L. Johnson. 2004. Population decline and taxonomic status of the Illinois chorus frog (Pseudacris streckeri illoensis) in Arkansas. Joint meeting of Ichthyologists and Herpetologists. May 26-31; Norman, OK. Poster. Sako, A., C. O'Reilly and R. L. Johnson. 2004. Behavior of rare earth and trace elements in Lake Tanganyika and its three major tributaries. American Geophysical Union; February 13-17; San Francisco, CA. Poster. Weston, M. and R.L. Johnson. 2004. Migration of yellowcheek darters (Etheostoma moorei) in the Little Red River watershed. Arkansas American Fisheries Society meeting, February 4, Pine Bluff. Johnson, R.L. and S. Blumenshine. 2003. Population estimates/genetic structure of an endemic species of darter, Etheostoma moorei Raney & Suttkus, of the upper Little Red River, Arkansas. American Fisheries Society, August 13, Quebec City Blumenshine, S and R.L. Johnson. 2003. Factors affecting growth rates in Little Red River brown trout and potential benefits of forage base enhancement. American Fisheries Society, August 14, Quebec City R.L. Johnson and K. A. Williams (former ASU undergraduate). 2003. Genetic relationships of some common Arkansas freshwater sunfishes (Centrarchidae: Lepomis) inferred from restriction endonuclease analysis of mitochondrial DNA. Arkansas Academy of Sciences, April 5, Fayetteville, AR. C. F. Cavenaugh (ASU undergraduate) and R.L. Johnson. 2003. Genetic similarity of shadow and Ozark basses (Ambloplites) as determined by mitochondrial DNA analysis. Arkansas Academy of Sciences, April 5, Fayetteville, AR.

C. F. Cavenaugh (ASU undergraduate) and R.L. Johnson. 2003. Genetic similarity of shadow and Ozark basses (Ambloplites) as determined by mitochondrial DNA analysis. Joint meeting of Arkansas and Tennessee Chapters of American Fisheries Society, March 4, Jackson, TN. L. Kanieski, R. Grippo, and R.L. Johnson. Effects of streambank stabilization and reduction of cattle access as a best management plan on the South Fork of the Spring River, AR. Arkansas Soil and Water Education Conference, January 15, 2002. T. Harmon and R.L. Johnson. A survey of the macroinvertebrates and brown trout (Salmo trutta) feeding habits, condition and growth within the Little Red River. American Fisheries Society, Southern Division, February 23, 2002. L. Kanieski, R. Grippo, and R.L. Johnson. The effects of streambank stabilization and reduction of cattle access as a best management plan on the South Fork of the Spring River, AR. American Fisheries Society, Southern Division, February 23, 2002. R.L. Johnson and S. Blumenshine. A bioenergetic and food web analysis of factors limiting brown trout growth in the Little Red River, AR tailwaters: Potential for management options? Arkansas Game and Fish Commission: Fish and Wildlife Research Symposium, October 15, 2002. Harmon, T. and R.L. Johnson. A survey of the macroinvertebrates and brown trout feeding habits within the Little Red River. American Fisheries Society, Arkansas Chapter, February 6, 2001. Staley, R. and R.L. Johnson. Identification of Florida largemouth bass alleles in hatcheries and reservoirs in Arkansas. 2001 Arkansas Academy of Sciences. April 14, 2001. Staley, R. and R.L. Johnson. Use of allozyme markers to evaluate largemouth bass populations in private and public ponds in Arkansas. 2001 Arkansas Undergraduate Research Conference. April 20, 2001. Williams, A. and R.L. Johnson. Genetic characteristics of and phylogenetics of sunfishes (Centrarchidae: Lepomis). 2001 Arkansas Undergraduate Research Conference. April 20, 2001. Johnson, R.L. R. Mitchell, and G.L. Harp. Genetic structure of an endemic species of darter Etheostoma moorei Raney and Suttkus of the upper Little Red River, Arkansas. American Fisheries Society, National Meeting, August 22, 2001 Harmon, T. and R.L. Johnson. A survey of the macroinvertebrates and brown trout feeding habits of the Little Red River, AR. Arkansas Game and Fish Commission: Fish and Wildlife Research Symposium, September 19, 2001. Mitchell, R.M., G.L. Harp, and R.L. Johnson. Genetic and meristic variations between

and within populations of Etheostoma moorei (Yellowcheek darter). American Fisheries Society, Arkansas Chapter, February 6, 2000. Johnson, R.L., R.M. Mitchell, and G.L. Harp. Genetic variation in a bottlenecked endemic species of darter (Etheostoma moorei) of the Little Red River, Arkansas. American Fisheries Society, Southern Division, February, 2000. Johnson, R.L., D. Ward, and R.S. Grippo. Physicochemical characteristics and macroinvertebrate assemblages of riffles upstream and downstream of a streambank impacted by unrestricted cattle access. Arkansas Academy of Sciences, April 8, 2000. Harmon, T. and R.L. Johnson. A survey of the macroinvertebrates and brown trout feeding habits of the Little Red River, AR. Arkansas Game and Fish Commission: Fish and Wildlife Research Symposium, June 20, 2000. Johnson, R.L., J.B. Magee and T.A. Hodge. 1999. Genetic relationships among several species of freshwater black basses (Genus Micropterus)as determined by mitochondrial DNA analysis. Am. Fish. Soc., Southern Division, February 28. Chattanooga, TN. Johnson, R.L. 1999. Icthyofaunal distribution on the upper, middle and lower reaches of the Strawberry River, AR. Am. Fish. Soc., Arkansas Chapter, February 9. Little Rock, AR. Mitchell, R., G.L. Harp and R.L. Johnson. 1999. Genetic and meristic variations between and within populations of Etheostoma moorei (Yellowcheek darter). Am. Fish. Soc., Arkansas Chapter, February 9. Little Rock, AR. Dye, D. and R.L. Johnson. 1999. Genetic distance for the blue and channel catfishes (Genus: Ictalurus) as determined by mitochondrial DNA analysis. 1999 Arkansas Undergraduate Research Conference and Space Grant Symposium. April 24. Arkadelphia, AR. Magee, J. and R.L. Johnson. 1998. Genetic relationships of the freshwater black basses (Genus Micropterus) as determined by mitochondrial DNA analysis. Am. Fish. Soc., Arkansas, Kansas and Oklahoma Chapters, February 11. Fayetteville, AR. Hodge, T. and R.L. Johnson. 1997. Genetic distance between the largemouth, smallmouth and spotted basses (Genus Micropterus) as determined by mitochondrial DNA analysis. Am. Fish. Soc., Southern Division., February 14. San Antonio, TX. Johnson, R.L. 1997. Comparison of growth, relative weight and health of largemouth bass in two Arkansas Lakes. Am. Fish. Soc., AR Chapter., February 26. Yellville, AR. Hodge, T. and R.L. Johnson. 1997. Genetic distance between the largemouth, smallmouth and spotted basses (Genus Micropterus) as determined by mitochondrial DNA analysis. AR Acad. Sci.; April 5. Montecello, AR.

Davis, R. and R.L. Johnson. 1997. A study of age, growth and condition of largemouth bass, Micropterus salmoides, of Lake Ashbaugh, Arkansas. AR. Acad. Sci.; April 5. Montecello, AR. Johnson, R.L., F.Q. Liang, K. Milam, and J.L. Farris. 1997. Genetic diversity, and cellulolytic activity among several species of Unionid mussels in Arkansas. National Shellfisheries Association, April 23. Fort Walton Beach, FL. Johnson, R.L. 1996. Genetic structure correlated with age and growth of the largemouth bass population in Lake Ashbaugh, Arkansas. American Fisheries Society, Southern Division, Mobile, AL. Liang, F.Q. and R.L. Johnson. 1996. Allozyme studies of selected species in Unionidae in the Cache and White Rivers, Arkansas. American Fisheries Society, Southern Division, Mobile, AL. Johnson, R.L. 1996. Comparison of growth, relative weight and health of largemouth bass in two Arkansas Lakes. Am. Fish. Soc., AR Chapter., February 15. Jonesboro, AR. Johnson, R.L. 1996. Phenotype, relative weight, length at age and health of largemouth bass in Lake Ashbaugh, AR. Am. Fish. Soc., Southern Division., February 23. Mobile, AL. Johnson, R.L. and T. Hodge. 1996. Genetic distance for the largemouth and smallmouth basses (Genus: Micropterus) as determined by analysis of mitochondrial DNA. Poster. Southeastern Association of Fish and Wildlife Agencies., October 5-9. Hot Springs, AR. Johnson, R.L. 1995. Genetic structure correlated with age and growth of the largemouth bass population in Lake Ashbaugh, Arkansas. Am. Fish. Soc., AR Chapter., Pine Bluff, AR. Johnson, R.L. 1995. Genetic structure correlated with age and growth of the largemouth bass population in Lake Ashbaugh, Arkansas. AR Acad. Sci., Pine Bluff, AR. Petty, C. and R.L. Johnson. 1995. Genetic distance between the blue and channel catfish as determined by mitochondrial DNA analysis. AR Undergrad. Res. Conf., Henderson St. U.

Liang, F.Q. and R.L. Johnson. 1995. Allozyme studies of selected species in Unionidae in the Cache and White Rivers, Arkansas. AR Acad.Sci., Pine Bluff, AR. Johnson, R.L. 1995. Genotype, condition and health of largemouth bass in two northern Arkansas lakes. Southeastern Association of Fish and Wildlife Agencies. Nashville, TN.

Poster. Johnson, R.L. 1994. Chain termination sequencing of DNA using silver sequencing technique. AR. Acad. Sci.; Jonesboro, AR.

Davis, R. and R.L. Johnson. 1994. Age and growth of the largemouth bass of Lake Ashbaugh, Arkansas. AR. Acad. Sci.; Jonesboro, AR. Parker, M. and R.L. Johnson. 1994. Rapid isolation of mitochondrial DNA suitable for amplification by way of n-butanol. SILO Undergrad. Res. Fellow. Little Rock, AR. ROLE AS ADVISOR/RECRUITER Chair, Pre-professional Committee

1. Meet with prospective students and their parents to describe departmental programs. 2. Coordinate our departmental component of New Student Orientations. 3. Serve as primary advisor for ~ 70 preprofessional emphasis majors and as secondary advisor for whomever needs additional help. 4. Perform many graduation check sheets to verify student graduation. 5. Advise transfer and potential transfer students. 6. Determine the suitability of courses for transfer students. 7. Meet with prospective graduate students 8. Development of course, Techniques for Medical Exam Test Taking, to enhance preparedness for professional standardized exams. 9. Development of career development component of First Year Experience. 10. Schedule interviews for and evaluations of students applying for professional programs. 11. Send evaluation packets to professional schools. 12. Coordinate professional speakers and representatives of professional schools to speak to our students. 13. On-campus participation in the Select-A-Major Fair and Senior Preview Days for prospective students. 14. Off-campus speaker to AHEC Mash Program and students of Nettleton High School for Career Days.

Argelia Lorence, Ph.D. Assistant Professor in Metabolic Engineering

Arkansas Biosciences Institute and Department of Chemistry and Physics Arkansas State University

PO Box 639, State University, AR, 72467, USA Office 870 680 4322, Fax 870 680 4348, [email protected]

Birth date and place of birth September 4, 1969, Mexico City, Mexico

Languages English, Spanish

Education PhD, Biotechnology (December, 1997) Instituto de Biotecnología (IBT), Universidad Nacional

Autónoma de México (UNAM), Cuernavaca, Mexico. Advisor: Prof. Alejandra Bravo. Dissertation: “Analysis of the Pore-forming Activity of Bacillus thuringiensis Cry Proteins in the Presence of their Native Receptor”

MS, Biotechnology (March, 1995), Instituto de Biotecnología (IBT), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Mexico. Advisor: Prof. Rodolfo Quintero-Ramírez. Dissertation: “Design of a Novel Screening Method for New Bacillus thuringiensis δ-Endotoxins”

BS, Biochemical Engineering, Universidad Autónoma Metropolitana-Iztapalapa(UAM-I), Mexico, 1991.

Continuous education “Teaching that Promotes Learning”, workshop organized by the Faculty Center for Learning and

Teaching. Speaker: Dr. Maryellen Weimer, author of the book “Learner-Centered Teaching” from Penn State University. Arkansas State University, Jonesboro, AR, September 13, 2007.

“Finding Out How Well Students Are Learning What We Are Teaching: An Introduction to Classroom Assessment”, and “Making Real the Scholarship of Teaching and Learning: Developing Your Own Classroom Research Agenda”. Speaker: Dr. Thomas Angelo from Victoria University of Wellington, New Zeeland. Workshops organized by Mrs. Barbara Doyle, Director of Assessment Arkansas State University, Jonesboro, April 4, 2007.

“Designing Courses for More Significant Learning Experiences” organized by the Office of Research and Academic Affairs. Presenter Dr. Dee Fink, author of the book “Creative Significant Leaning Experiences: An Integrated Approach to Designing College Courses”, Arkansas State University, Jonesboro, September 14, 2006.

“Coaching Strong Women in the Art of Strategic Persuasion” organized by the Committee On the Advancement of Women Chemists (COACh) Annual Spring Meeting of the American Chemical Society. Atlanta, GA, March 25, 2006.

“Communicating Science to the Public” organized by Drs. Aldemaro Romero and Amy Pierce, Arkansas State University, Jonesboro, March 4, 2006.

“Process Oriented Guided Inquiry Learning in the Classroom and the Laboratory” SE-SW Joint Regional Meeting of the American Chemical Society, Peabody Hotel, Memphis, TN, November 4th, 2005.

Inter-Agency Conference on Metabolic Engineering 05, February 3, 2005. National Science Foundation. Arlington, VA.

“Realizing the Vision: Leading Edge Technologies in Biological Systems” organized by the National Science Foundation. December 13-14, 2004. Cosmos Club, Washington, D.C.

Inter-Agency Conference on Metabolic Engineering 2004. February 6, 2004. National Science Foundation. Arlington, VA.

Training course for scientists to facilitate their abilities to communicate science to the media imparted by Fleishman-Hillard of Mexico. Organized by AgroBio México and the Mexican Society of Biotechnology and Bioengineering (SMBB). September 9, 2001, Veracruz, Mexico.

“Biosynthesis of Plant Secondary Metabolites” imparted by Prof. Robert Verpoorte. Organized by CINVESTAV-IPN. July 23-25 2001, Mexico City, Mexico.

“Cloning and characterization of strictosidine synthase from Camptotheca acuminata cell cultures”, visiting scientist, laboratory of Dr. Edmundo Lozoya-Gloria, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-Irapuato, June 19 - July 9 1999, Irapuato, Mexico.

“3rd International Symposia of Phytomedicines” Organized by Instituto Mexicano del Seguro Social (IMSS) and Farmasa Schwabe. May 21 1999, Mexico City, Mexico.

“Priorities of Research and Development in Agrobiotechnology” Organized by Centro Para la Innovación Tecnológica/UNAM. September 24-25 1993, Mexico City, Mexico.

“3rd Advanced Course of Biotechnological Processes: Scale-Up” Organized by Biotechnology Program for Latin America and the Caribbean/UNIDO, IBT/UNAM, and CEIB/UAEM, October 12-23, 1992, Cuernavaca, Mexico.

Professional Experience August 2005 to present Tenure-Track Assistant Professor in Metabolic Engineering Arkansas Biosciences Institute (ABI), Arkansas State University (ASU), Jonesboro, AR.

- Study of the role of ascorbate in the control of aging and reproductive activity in plants - Metabolic engineering of vitamin C in plants - Study of the role of ascorbate at conferring plants tolerance to environmental pollutants (TCE phytoremediation project in collaboration with Drs. Carole Cramer and Fabricio Medina-Bolivar, ABI/ASU, and Kathleen Gilbert, ACHRI) - Survey of the vitamin C foliar content of plants of the mustard family growing in Arkansas - Study of the role of ascorbate in mitigating ER and cellular stress associated with plant-based protein production (in collaboration with Dr. Maureen Dolan, ABI/ASU, and Vibha Srivastava, UAF) - Intersection of ascorbate regulation, jasmonate-signaling, and defense against herbivores in plants (in collaboration with Dr. Fiona Goggin, UAF) - Arabidopsis as a model to study toxicity and fate of selected nanomaterials (collaboration with Dr. Alex Biris, Center of Nanotechnology, UALR) - Metabolite profiling of the vitamin C metabolic network in plants (collaboration with Drs. Robyn Hannigan and Vipin Nair, ABI/ASU) - Metabolic engineering of taxanes produced by hazelnut cell cultures (collaboration with Dr. Mariangela Miele, University of Genova, Italy) - Metabolic engineering of triterpenes with sedative properties produced by Galphimia glauca cell and hairy roots cultures (collaboration with Dr. María Luisa Villarreal (CEIB-UAEM, Cuernavaca, Mexico) - Study of the pore-forming activity of resin glycosides (collaboration with Dr. Rogelio Pereda-Miranda, Facultad de Química-UNAM, Mexico City, Mexico) - Molecular speciation of selected Mexican medicinal plants (collaboration with Dr. Rachel Mata, Facultad de Química-UNAM, Mexico City, Mexico)

- Metabolic engineering for the enhancement of nutritional and agronomical traits of rice varieties (collaboration with Dr. Gregory Phillips, ASU-Agriculture, and Dr. Helen Miller, USDA-Stuttgart, AR) - Use and development of analytical tools to measure antioxidant activity of plant extracts - Survey about fruits and vegetable consumption among children and adults in the Delta region of Arkansas (collaboration with Dr. Patrick Steward, University of Arkansas –Fayetteville) - Extensive teaching and mentoring activities (high school, undergraduate and graduate students).

April 2002 – July 2005 Post-doctoral Research Associate, Department of Plant Pathology,

Physiology and Weed Science (PPWS), Virginia Tech, Blacksburg, VA - Discovery and study of a new biosynthetic pathway for vitamin C in plants using myo-inositol as a precursor - Metabolic engineering of the vitamin C biosynthetic network in Arabidopsis and crop plants - Metabolic engineering of the biosynthetic pathway of opiates in opium poppy (Papaver somniferum) - Extensive advising and mentoring of laboratory technicians, graduate and undergraduate students, visiting scholars and summer interns.

April 1998- March 2002 Assistant Professor, Centro de Investigación en Biotecnología (CEIB), Universidad Autónoma del Estado de Morelos (UAEM), Cuernavaca, México. - Metabolic engineering of the indole alkaloid pathway in Camptotheca acuminata cell cultures. This research was funded via a Grant Award for Young Investigators (equivalent of the CAREER-NSF award) to A Lorence (PI) from Consejo Nacional de Ciencia y Tecnología (CONACYT)-Mexico (1999-2001) - Set-up of a laboratory of metabolic engineering in the Department of Natural Products at CEIB/UAEM

- Extensive teaching and mentoring activities (undergraduate and graduate students). August 2000 – June 2001 Visiting Scientist, Department of Plant Pathology, Physiology and

Weed Science (PPWS), Virginia Tech (VT), Blacksburg, VA - Metabolic engineering of indole and opiate alkaloid biosynthetic pathways. - Development of C. acuminata hairy roots (collaboration with Dr. Fabricio Medina-Bolivar). - Move and set-up of the Nessler lab at Virginia Tech and training of all new personnel. January - July 2000 Visiting Scientist, Department of Biology, Texas A&M University (TAMU),

College Station, TX - Metabolic engineering of indole-alkaloid biosynthesis: activation tagging of C. acuminata to identify transcription factors that regulate the pathway.

Awards and honors 2008 Winner Dean’s Horizons Award 2008, College of Sciences and Mathematics,

Arkansas State University. 2007- Elected Secretary of the Faculty Research Committee, Arkansas State University,

September 2007. Re-elected for the period 2008-2009. 2007 Ad-honorem external reviewer, National Council of Science, Technology and

Innovation (Secretaría Nacional de Ciencia, Tecnología e Innovación, SENACYT), Panama City, Panama, May 2007 to date.

2007 Featured member, Who’s Who among American Teachers and Educators, 11th edition.

2007 Co-author of finalist work nominated to Best Paper Award, Agribusiness Symposium, 17th Annual World Forum and Symposium: Food Culture: Tradition, Innovation and Trust- A positive Force for Modern Agribusiness, International Food and Agribusiness Management Association (IAMA), Parma, Italy. C. Schroeter, LA House and A Lorence. Fruits and Vegetable Consumption among College Students in Arkansas and Florida: Food Culture vs. Health Knowledge.

2006 Featured mentor in the book The Paths We Tread II, Minority Environmental Leadership Development Initiative (MELDI), University of Michigan.

2006 Member Sigma Xi, June 2006 to present. 2006 Travel Award, Committee on the Advancement of Women Chemists (COACh). 2002 Arthur Neish Young Investigator Award, Phytochemical Society of North America

(PSNA). 2002 Post-doctoral Travel Award, Virginia Tech. 2000 Post-doctoral Fellowship, UAEM, México. 1999-2001 Young Investigator Award (equivalent of the CAREER-NSF award) Consejo Nacional de Ciencia y Tecnología, (CONACYT), México 1999 Teaching Award, Facultad de Biología, Universidad Autónoma del Estado de

Morelos. 1998 "Alfonso Caso Medal” 1st place PhD, class of 1997, UNAM, México. 1997 "Gabino Barreda Medal” 1st place MS, class of 1995, UNAM, México. 1995-2001 Scholar, Sistema Nacional de Investigadores (SNI), México. 1992-1997 Scholar, CONACYT, México. Funding for MS and PhD studies. 1993 1st place "Maestro Jesus Silva Herzog Economy Award” Participant in the winner

project: “The Technological Change in the Mexican Agriculture and Agro-industry”. Research sponsors Current

Title: “Role of Ascorbate in Coordinating Growth and Senescence in Arabidopsis thaliana” Agency: National Institute of Health (NIH), Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE), A Lorence (PI) Sub-award: $93,487.00 (05/01/08- 04/30/09) Total sub-award: $603,574.00 (01/01/06 – 04/30/10) General Award No: NIH-NCCR 5 P20 RR016460-05 to L Cornett “Partnerships for Biomedical Research in Arkansas” (05/01/05 – 04/30/10).

Title: “Unraveling Sedative Triterpene Synthesis in Galphimia glauca: Phytochemistry and Functional Genomics Join Forces” Agency: Faculty Research Fund, Arkansas State University A Lorence (PI) Award: $6,500.00 (07/01/06 – 12/31/08).

Title: Collaborative Seed Grant: Mechanisms of Toxicity and Remediation of Superfund Environmental Toxicants”

Agency: Arkansas Biosciences Institute, Arkansas State University A Lorence, F Medina-Bolivar and K Redeker (Co-PIs) Award: $57,336.00 (07/01/06 – 06/30/09).

Title: “Arabidopsis as a Tool to Assess Toxicity and Fate of Nanomaterials” Agency: Nanotechnology Center, UALR A Lorence (PI) Award: $25,000.00 (10/01/07 – 12/31/08).

Title: “Role of Ascorbate in Mitigating ER and Cellular Stress Associated with Transient and Stable Plant-Based Protein Production” Agency: NSF EPSCoR P3 Center Collaborative Seed Grant Program Overall Statewide Project headed by Carole Cramer (ASU), Steve Grace (UALR) and Kenneth Korth (UAF) A Lorence (PI, ASU), M Dolan (Co-PI, ASU), and V Srivastava (Co-PI, UAF) Award: $249,860.00 (05/15/08 – 11/14/09). Title: “Intersection of Ascorbate Regulation, Jasmonate-Signaling, and Defense Against Hervibores in Plants” Agency: NSF EPSCoR P3 Center Collaborative Seed Grant Program Statewide Project headed by Carole Cramer (ASU), Steve Grace (UALR) and Kenneth Korth (UAF) Fiona Goggin (Co-PI), and Argelia Lorence (Co-PI) Award: $249,978.00 (05/15/08 – 03//14/10). Title: “TCE toxicity and remediation” Agency: Arkansas Biosciences Institute at the Arkansas Children’s Hospital Research Institute (ACHRI) A Lorence, F Medina-Bolivar and C. Cramer (Co-PIs ASU), K Gilbert (PI ACHRI) Award: $180,000.00 (08/01/08 – 06/30/10). Title: “Acquisition of qRT-PCR and Electrophysiology Equipment” Agency: NIH, Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE) M Srivatsan (Co-PI), A Lorence (Co-PI) and R Buchanan (Co-PI) Award: $50,000.00 (01/01/00-04/30/09).

Participation in funded proposals led by others

Title: “Undergraduate Research and Mentoring in the Biological Sciences: Cross-disciplinary Research at the Intersection of Biotechnology and the Environment” Agency: NSF – Undergraduate Research and Mentoring in the Biological Sciences R Hannigan (PI), and Roger Buchanan (Co-PI) A Lorence one of 10 faculty mentors participating in two areas of this project: molecular diagnostics and metabolite identification Award: $810,170 (01/15/08 – 12/15/10). Title: “GK12: Land Use, Land Cover, and Biodiversity in the Mississippi Embayment” Agency: NSF-DGE A Christian (PI), and R Hannigan (Co-PI) Award: $2,242,565.00 A Lorence one of the faculty mentors participating in this project. Rodney Shea Harris, EVS-MS student at the Lorence Lab, received one of the GK12 scholarships for the period 07/01/08-06/30/09.

Pending Title: “A Center for Bio- and Phytoremediation Research in Arkansas: Challenges and Opportunities” Agency: NSF EPSCoR (white paper for next NSF EPSCoR competition) GJ Thoma (PI UAF), KM Gilbert (Co-PI UAMS/ACHRI), and A Lorence (Co-PI ASU) Submitted: December 1st, 2008 Selected as one of 8 finalists of a total of 21 proposals; an 8-page follow up pre-proposal is due February 16, 2009. Title: “Strategies for the Development of Rice Varieties with Enhanced Biomass, Antioxidant Content and Tolerance to Abiotic Stresses” Agency: Arkansas Rice Research and Promotion Board (RRPB) A Lorence (PI), G Phillips (Co-PI), and V Srivastava (Co-PI) Amount requested: $186,144.40 (03/01/09-02/28/11) Submitted: January 12, 2009. Title: “Mechanisms leading to enhanced tolerance to oxidative stress and increased lifespan in Arabidopsis: Role of mitochondrial, ER, and chloroplastic enzymes involved in ascorbate biosynthesis” Agency: National Institute of Health (NIH), Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE), A Lorence (PI) Pre-proposal submitted: February 4, 2009 Title: “Artemisinin Biosynthesis: Role of Reactive Oxygen” Agency: NIH AREA P Weathers (PI), A Lorence (Consultant) Amount requested: $3851 Submitted: February 2009

Past

Title: “Acquisition of New Equipment and Shared Facilities” Agency: NIH, Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE) R Buchanan (Co-PI), M Srivatsan (Co-PI) and A Lorence (Co-PI) Award: $24,518.00 (01/01/08-04/30/08).

Title: “Developing an Immunotoxicology Center in Arkansas”

Agency: Arkansas Biosciences Institute at the Arkansas Children’s Hospital Research Institute (ACHRI) K Gilbert (PI), S Blossom, and B Przybyla (ACHRI), N Pumford (University of Arkansas at Fayetteville), J Fuscoe (National Center for Toxicological Research), F Medina-Bolivar, K Redeker, and A Lorence (Arkansas State University). Award: $200,000.00 (07/01/07 – 06/30/08). Title: “Study and Manipulation of the Vitamin C – Cell Wall Metabolic Network for the Development of Plants with Enhanced Nutritional and Agronomical Properties” Agency: Arkansas Biosciences Institute A Lorence (PI) Award: $230,000.00 (08/01/05 – 06/30/08, set-up package).

Title: Funding to attend “Workshop on HPTLC-MS”, October 9-11, 2006, Berlin, Germany Agencies: ASU Sponsored Research Assistance and ASU Research Foundation A Lorence (PI) Award: $2,000.00 (July - October 2006). Title: “Metabolic Engineering for the Discovery of Human Therapeutics in Tobacco” Agency: Tobacco Initiative Fund, Virginia Tech F Medina-Bolivar (PI), and A Lorence (Co-PI) Award: $29,000.00 (November 2004 - July 2005).

Title: “Transformation of Camptotheca acuminata Cell Lines for the Production of

Camptothecin, A Terpene with Anticancer and Antiretroviral Activities" Agency: Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico Young Investigator Award Project, A Lorence (PI) Award: $100,000.00 (January 1999 - December 2001). Title: “Characterization of Regions in the Domain I of Bacillus thuringiensis Cry Proteins

Involved in Their Pore- Forming Activity” Agency: Dirección General de Estudios de Posgrado, UNAM, Mexico A Lorence (PI) Award: $4,000.00 (1995 - 1997). Consulting November 01 – March 02

Bioskinco, SA de CV, Mexican biotechnological company producer of “Epifast” skin substitute for the treatment of diabetic foot, burns and other skin conditions. Main activity: preparation of grant proposals to the Mexican government.

1995-1998 CAMBIOTEC, initiative of the International Development Research Center (IDRC, Canada). International network with the mission to facilitate biotechnology-based applications in the agri-food and environmental management fields in Latin America. Advisor: Dr. José Luis Solleiro-Rebolledo. Main activity: development of “state of the art” reports published in Spanish and distributed in México, Colombia, Chile, Argentina and Canada. Topics: biopesticides (1996), potato (1997) and agrobiologicals (1998).

October 91 – January 92 Advisor: Prof. Rodolfo Quintero-Ramírez, Director of the Biotechnology Regional Program

for Latin America and the Caribbean of the United Nations (UNIDO). Main activities: design of an industrial plant to produce Bacillus thuringiensis-based biopesticides to satisfy the demand of the countries of “Pacto Andino” (Bolivia, Colombia, Ecuador, Peru, and Venezuela). Make a directory of Mexican biotechnological companies.

Scientific publications - English (*student authors) Peer-reviewed articles 1. Suza W, Harris RS*, and Lorence A (2008) Hairy roots: From high-value metabolite

production to phytoremediation. Electronic Journal of Integrative Biosciences. Published online November 21, 2008. http://clt.astate.edu/electronicjournal/Articles.htm

http://clt.astate.edu/electronicjournal/Articles.htm

2. Dabul ANG*, Belefant-Miller HB, RoyChowdhury M, Hubstenberger JF, Lorence A, and Phillips GC (2008) Screening of a broad range of rice (Oryza sativa L.) germplasm for in vitro rapid regeneration and development of an early prediction system. In Vitro Cellular and Developmental Biology – Plant, Vol. 44. Online November 21, 2008. DOI 10.1007/s11627-008-9174-6.

3. Schroeter C, House LA and Lorence A (2007) Fruits and Vegetable Consumption Among College Students in Arkansas and Florida: Food Culture vs. Health Knowledge. International Food and Agribusiness Management Review 10: 63-89.

4. Lorence A, Mendes P, Chevone BI, and Nessler CL (2004) myo- Inositol Oxygenase Offers a Possible Entry Point into Plant Ascorbate Biosynthesis. Plant Physiology 134: 1200-1205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14976233

5. Lorence A, Medina-Bolivar F, and Nessler CL (2004) Camptothecin and 10-Hydroxycamptothecin from Camptotheca acuminata Hairy Roots. Plant Cell Reports 22: 437-441.

6. Lorence A and Nessler CL (2004) Camptothecin, Over Four Decades of Surprising Findings. Phytochemistry 65: 2735-2749. Review paper by invitation to section Molecules of Interest.

7. Lorence A, and Verpoorte R (2004) Gene Transfer and Expression in Plants. Methods in Molecular Biology 267: 329-350.

8. Radzio J*, Lorence A, Chevone BI, and Nessler CL (2003) L-Gulono-1,4-lactone Oxidase Expression Rescues Vitamin C Deficient Arabidopsis (vtc) Mutants. Plant Molecular Biology 53: 837-844.

9. Soberón M, Pérez RV, Núñez-Valdéz ME, Lorence A, Gómez I, Sánchez J, and Bravo A (2000) Evidence for Intermolecular Interaction as a Necessary step for Pore-Formation Activity and Toxicity of Bacillus thuringiensis Cry1Ab Toxin. FEMS Microbiology Letters 191: 221-225.

10. Lorence A, Darszon A, and Bravo A (1997) Aminopeptidase Dependent Pore Formation of Bacillus thuringiensis Cry1Ac Toxin on Trichoplusia ni Membranes. FEBS Letters 414: 303-307.

11. Lorence A, Darszon A, Díaz C, Liévano A, Quintero R, and Bravo A (1995) δ-Endotoxins Induce Cation Channels in Spodoptera frugiperda Brush Border Membrane in Suspension and in Planar Lipid Bilayers”. FEBS Letters 360: 217-222.

12. Bravo A, Lorence A, and Quintero R (1995) Biopesticides Compatible with the Environment: Bacillus thuringiensis a Unique Model. Biocontrol 1: 41-55.

Peer-reviewed abstracts 1. Lisko KA*, Harris RS*, Yactayo-Chang J* and Lorence, A (2008) “Engineering ascorbate for

enhanced growth, nutritional content, and stress tolerance in crops” In Vitro Cellular and Developmental Biology Animal 44: S28.

2. Nessler CL, Lorence A, Chevone B, and Mendes P (2005) “The vitamin C network: New branches in plant biochemistry”. In Vitro Cellular and Developmental Biology Animal 41: 18A.

3. Lorence A, Sánchez J, Darszon A, and Bravo A (1996) Pore Formation of the Bacillus thuringiensis Cry1Ac Toxin in Presence of the Trichoplusia ni Toxin-Receptor in Planar Lipid Bilayers” Medical Microbiology and Immunology 185: 114.

Peer-reviewed articles (submitted) 1. Mannan A, Liu C, Towler MJ, Vail D, Lorence A, Weathers PJ (2009) DMSO stimulates

production of artemisinin suggesting that the sesquiterpene may also function as a ROS sink in Artemisia annua. Submitted to Plant Cell Reports.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14976233

2. Zhang W, Lorence A, Gruszewski HA, Chevone BI and Nessler CL (2009) AMR1, an Arabidopsis gene that coordinately and negatively regulates the mannose/L-galactose ascorbic acid biosynthetic pathway. Submitted to Plant Physiology.

3. Lisko KA*, Jullian B*, Vaughan MM*, Belisle M*, Chevone BI, Mendes P, Nessler CL and Lorence A (2009) Higher foliar vitamin C content leads to enhanced growth and stress tolerance. Submitted to Plant Cell Reports.

Manuscripts in preparation 1. Lorence A, Trujillo G*, Yactayo-Chang J*, Reidy M, Mendes P, Chevone BI, Cramer, C, and

Nessler CL (2009) Identification and characterization of a glucuronic acid reductase in Arabidopsis thaliana”. In preparation to Plant Physiology.

2. Pereda-Miranda R, Villatoro-Vera R*, Bah M, and Lorence A (2009) Cell membrane disruption by morning glory resin glycosides. In preparation to Phytochemistry.

3. Lorence A, Woffenden BJ, Martínez-Quintana J*, Nopo-Olazabal L, Nessler CL, and Medina-Bolivar F (2009) Enhanced production of specialized metabolites in tobacco over-expressing an AP2-type transcription factor. In preparation to Plant Molecular Biology.

4. Nopo-Olazabal L, Simeon S*, Hannigan R, Lorence A, and Medina-Bolivar F (2009) Elicitation and secretion of sesquiterpenes in hairy roots cultured in the Liquid LabTM bioreactor. In preparation to Acta Horticulturae.

Co-editor of book and special issue of peer-reviewed journal Book

Co-editor of the book: “Recombinant Gene Expression. Reviews and Protocols” (2004) P Balbás and A Lorence (eds). Molecular Biology Series. Humana Press, Totowa, 535 pp. ISBN 1-58829-262-2. Included in the list of the 2004-2005 best sellers of Humana Press.

Special issue of scientific journal Co-editor of a special issue “Hairy Roots: Recent Applications in Plant Biotechnology” of the

Electronic Journal of Integrative Biosciences (http://clt.astate.edu/electronicjournal/). A Lorence and F Medina-Bolivar (co-editors), vol. 3, special issue 1. October 2008.

Book chapters 1. A Lorence and CL Nessler (2007) Pathway engineering of the plant vitamin C metabolic

network. In “Applications of Plant Metabolic Engineering” R Verpoorte, AW Alfermann and TS Johnson (eds). Springer, Dordrecht, chapter 8, pp 197-217.

2. E Aranda, A Lorence, and MR Trejo (2000) Rural Production of Bacillus thuringiensis by Solid State Fermentation. In "Entomopathogenic Bacteria: From Laboratory to Field Application". JF Charles, A Delecluse, and C Neilsen-Le Roux (eds). Kluwer Academic Publishers, Dordrecht, p. 317-332. ISBN 0-7923-6523-2.

3. A Lorence and R Quintero (2000) In Search of Novel and Better Bioinsecticides. In “Environmental Biotechnology and Cleaner Bioprocesses”. EJ Olguín, G Sánchez, and E Hernández (eds). Taylor & Francis, London, p. 275-284. ISBN 0-7484-0729-4.

4. R Quintero, A Lorence, and C Wacher (1999) Cereal Fermentation in Latin American Countries. In “Fermented Cereals- A Global Perspective”. Food and Agriculture Organization of the United Nations (FAO). Agricultural Services Bulletin 138, Rome, p. 99-114. ISBN 92-5-104296-9.

5. A Lorence and R Quintero (1997) Development of New Bioinsecticides. In “International Course: Biochemical Engineering Applications in Environmental Biotechnology and Cleaner Production”. COBIOTECH Scientific Committee for Biotechnology of the International Council of Scientific Unions ICSU. Electronic course, available at: http://www.icaiti.org.gt.

http://clt.astate.edu/electronicjournal/

6. Bravo A, J Cerón, E Aranda, A Lorence, and R Quintero (1995) Screening of Bacillus thuringiensis Strains With Novel Insecticidal Activities. In “Bacillus thuringiensis Biotechnology and Environmental Benefits”. T-Y Feng et al. (eds). Hiang Yuan Publishing, Taipei, p. 87-103.

Intellectual property 1. US Patent Application No. 10/538,885 (June 14, 2005). Publication numbers

WO/2004/061098 and PCT/US03/027779 “Manipulation of Ascorbic Acid Level in Plants” CL Nessler, A Lorence, P Mendes, and BI Chevone.

2. US Patent Application No. 11/908,551 (September 13, 2007). Publication numbers WO/2006/104503 and PCT/US2005/022179. “Increase in Plant Growth Rate, Biomass Accumulation and Stress Tolerance in Plants Over Expressing Genes of Ascorbic Acid-Cell Wall Biosynthetic Network” CL Nessler, A Lorence, P Mendes, and BI Chevone.

Technical Reports 1. Report 2007-2008 “Role of Ascorbate in Coordinating Growth and Senescence in

Arabidopsis thaliana”. Agency: Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE), National Institute of Health (NIH). February 11th, 2008.

2. Report 2006-2007 “Role of Ascorbate in Coordinating Growth and Senescence in Arabidopsis thaliana”. Agency: Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE), National Institute of Health (NIH). February 5th, 2007.

Outreach

A Lorence (2005) “Metabolic Engineering for the Improvement of the Nutritional and Agronomical Value of Crops” Annual Report of the Arkansas State University Foundation.

Scientific publications (Spanish) Peer-reviewed articles 1. A Lorence, RL González and JL Solleiro (1993) Basic Elements for the Development and

Spreading of Biotechnology, A Comparative Analysis (Los Elementos Básicos para el Desarrollo y Difusión de la Biotecnología: Un Análisis Comparativo). Biotecnología 3: 1-7.

2. A Bravo, A Lorence and R Quintero (1992) Perspectives for the Use of Bacillus thuringiensis as Bioinsecticide (Perspectivas en la Utilización de Bacillus thuringiensis como Bioinsecticida). Biotecnología 2: 139-154.

Technical Reports 1. A Lorence (1999) Agrobiologicals (Agrobiológicos). Cuadernos de Vigilancia Tecnológica.

JL Solleiro and R Castañón (eds). Iniciativa Canadá-América Latina de Biotecnología para el Desarrollo Sustentable (CAMBIOTEC). International Development Research Center (IDRC) and Núcleo de Innovación Tecnológica del Instituto de Ingeniería/UNAM, Mexico City, 58 p.

2. A Lorence (1996) Biopesticides in the Context of Sustainable Agriculture (Los Biopesticidas en el Marco de la Agricultura Sustentable). Cuadernos de Vigilancia Tecnológica. JL Solleiro and R Castañón (eds). Iniciativa Canadá-América Latina de Biotecnología para el Desarrollo Sustentable (CAMBIOTEC), International Development Research Center (IDRC) and Centro Para la Innovación Tecnológica/UNAM, Mexico City, 72 p.

Book chapters 1. P Balbás and A Lorence (2002) Corn Genetically Improved: Implications for the Agriculture

in the State of Morelos (Maíz Genéticamente Mejorado: Implicaciones para la Agricultura en

el Estado de Morelos). In “Land, Water and Corn II, Reality and Utopy” (“Tierra, Agua y Maíz II. Realidad y Utopia”). UNICEDES/UAEM, Cuernavaca, p. 167-182. ISBN 968-878-136-3.

2. P Balbás, C Abarca, AD Caro* and A Lorence (2000) Applications of Molecular Genetics in Medicine (Aplicaciones de la Genética Molecular en la Medicina). In “Biological Sciences: From Life Origin to Genetic Therapy” (“Ciencias Biológicas. Del Origen de la Vida a la Terapia Génica”). E Sánchez-Salinas and ML Ortiz-Hernández (eds). Universidad Autónoma del Estado de Morelos, Cuernavaca, p. 223-255. ISBN 968-878-055-3.

3. P Balbás and A Lorence (2000) Protein Biosynthesis by Recombinant DNA (La Biosíntesis de Proteínas por DNA Recombinante). In “Biological Sciences: From Life Origin to Genetic Therapy” (“Ciencias Biológicas, Del Origen de la Vida a la Terapia Génica”). E Sánchez-Salinas and ML Ortiz-Hernández (eds). Universidad Autónoma del Estado de Morelos, Cuernavaca, p. 182-222. ISBN 968-878-055-3.

4. A Lorence and P Balbás (1998) Molecular Biology, A General Overview (La Biología Molecular: Una Visión General). In “Biology. Molecular Bases at the Threshold of the XXI Century” (“Biología. Sus Bases Moleculares en el Umbral del Siglo XXI”). E Sánchez-Salinas and ML Ortiz-Hernández (eds). Universidad Autónoma del Estado de Morelos, Cuernavaca, p. 40-125. ISBN 968-878-038-3.

5. A Lorence (1997) Relevance and Potential of Biotechnology for Potato Crop (Importancia y Potencial de la Biotecnología para el Cultivo de Papa). In “Potato and Chilli Pepper” ("Papa y Chile"). Cuadernos de Vigilancia Tecnológica. JL Solleiro and R Castañón (eds). Iniciativa Canadá-América Latina de Biotecnología para el Desarrollo Sustentable (CAMBIOTEC), International Development Research Center (IDRC) and Centro para la Innovación Tecnológica/ UNAM. Mexico City, p. 11-78

6. A Bravo, M Ortíz, A Ortíz, J Cerón, E Aranda, J Sánchez, R Meza, ME Nuñez and A Lorence (1996) Search and Construction of New Insecticidal Proteins from Bacillus thuringiensis (Búsqueda y Construcción de Nuevas Proteínas Insecticidas de Bacillus thuringiensis). In “Frontiers in Biotechnology and Bioengineering” (“Fronteras en Biotecnología y Bioingeniería”). E Galindo (ed). Sociedad Mexicana de Biotecnología y Bioingeniería, Mexico City, p. 375-379. ISBN 968-7735-00-7.

7. A Lorence and R Quintero (1996) Molecular Mechanism of Action of Bacillus thuringiensis δ-Endotoxins (Mecanismo Molecular de Acción de las δ-Endotoxinas de Bacillus thuringiensis). In “Recent Progress in Biotechnology of Bacillus thuringiensis” ("Avances Recientes en la Biotecnología de Bacillus thuringiensis"). Luis J Galán-Wong, C Rodríguez-Padilla and HA Luna-Olvera (eds). Universidad Autónoma de Nuevo León (UANL), Monterrey, p. 63-113. ISBN 968-6337-98-9.

8. A Lorence (1992) Potential of Biotechnology for Tomato Production (Potencialidades de la Biotecnología Para la Producción de Tomate). In “Biotechnology and Its Socioeconomical and Political Consequences” (“La Biotecnología y sus Repercusiones Socioeconómicas y Políticas”). R Casas, M Chauvet and D Rodríguez (coords). Departamento de Sociología/UAM-A, Instituto de Investigaciones Económicas/UNAM, Instituto de Investigaciones Sociales/UNAM. Mexico City, p. 301-317. ISBN 968-36-2703-X.

Presentations at professional meetings and invited lectures (*student authors) Lectures (A Lorence, otherwise indicated) 1. Seminar (G Trujillo*, RS Harris*, G Wilson*). Plant Biotechnology Discussion Group,

Arkansas Biosciences Institute, Jonesboro, AR, January 23, 2009. “Progress in the study of the inositol pathway to vitamin C in plants”.

2. INVITED, lecture to be presented at the Symposium “Biofuels and Plant Produced Products”, Worcester Polytechnic Institute, Worcester, MA, October 27, 2008. “The many reasons why plants also need their vitamin C”.

3. INVITED, lecture presented at the Arkansas Biosciences Institute Fall Research Symposium, Science and Industry Advisory Committee Meeting, Little Rock, AR, October 7, 2008. “Leveraging vitamin C metabolism to develop plants that are better for us and the environment”

4. INVITED lecture presented at the Arkansas NSF EPSCoR Annual Meeting, Little Rock, AR, October 7, 2008. “Phytoremediation and Ecological Engineering in Arkansas: Challenges and Opportunities”

5. INVITED (F Goggin) lecture presented at the Arkansas NSF EPSCoR Annual Meeting, Little Rock, AR, October 6, 2008. “Intersection of Ascorbate Regulation, Jasmonate-Signaling, and Defense Against Hervibores in Plants” F Goggin and A Lorence.

6. INVITED (M Dolan) lecture presented at the Arkansas NSF EPSCoR Annual Meeting, Little Rock, AR, October 6, 2008. “Role of Ascorbate in Mitigating ER and Cellular Stress Associated with Transient and Stable Plant-Based Protein Production” M Dolan, V Srivastava and A Lorence.

7. Seminar (A Lorence, G Trujillo*, SI Aboobucker*, KA Lisko*, and W Suza). Plant Biotechnology Discussion Group, Arkansas Biosciences Institute, Jonesboro, AR, September 19, 2008. “Progress in the study of the inositol pathway to vitamin C in plants”.

8. INVITED, lecture presented at the Pan American Symposium Mexico 2008 “Pharmaceutical environment for students in pharmacy: current and future perspectives”, event organized by the Pan American Regional Office of the International Pharmaceutical Student’s Federation, September 8-11, 2008, Cuernavaca, Morelos, Mexico. “Progress in the study and manipulation of vitamin C biosynthesis in plants”.

9. INVITED, lecture presented at the state wide Arkansas EPSCoR P3 Training Conference, August 20-22, Petit Jean, AR. “The 101 in how to mine the Arabidopsis TAIR database”.

10. INVITED, lecture to scholars of the NSF-funded Research Internships in Science of the Environment (RISE), July 22, 2008, Arkansas State University, Jonesboro, AR. “The importance of networking”.

11. INVITED World Congress on In Vitro Biology, Society for In Vitro Biology, Tucson, AZ, June 14-18, 2008. “Engineering ascorbate for enhanced growth, nutritional content, and stress tolerance in crops” KA Lisko*, RS Harris*, J Yactayo-Chang* and A Lorence.

12. Oral presentation (G Wilson*), April 10, 2008, Undergraduate Scholar’s Day Conference, ASU, Jonesboro, AR. “Identification and cloning of glucuronolactonases of Arabidopsis thaliana” G Wilson*, G Trujillo*, M Belisle*, A Lorence.

13. Oral presentation (G Trujillo*), April 9, 2008, Graduate Scholar’s Day Conference, ASU, Jonesboro, AR. “Spatial and temporal expression patterns of genes in the myo-inositol pathway to ascorbate in Arabidopsis thaliana” G Trujillo* and A Lorence.

14. Oral presentation (SI Aboobucker*), April 9, 2008, Graduate Scholar’s Day Conference, ASU, Jonesboro, AR. “Identification and characterization of a functional L-gulono-1,4-lactone oxidase in Arabidopsis” SI Aboobucker* and A Lorence.

15. Seminar (KA Lisko*, RS Harris*, G Trujillo* and SI Aboobucker*), Plant Biotechnology Discussion Group, Arkansas Biosciences Institute, Jonesboro, AR, March 7, 2008. “Vitamin C biosynthesis in plants: An unfolding story” KA Lisko*, RS Harris*, G Trujillo*, SI Aboobucker*, and A Lorence.

16. INVITED, seminar Department of Entomology, University of Arkansas Fayetteville, January 29, 2008. “Vitamin C biosynthesis in plants: An unfolding story” A Lorence.

17. Seminar (M Belisle*, RS Harris*, J Yactayo*, and A Lorence), Plant Biotechnology Discussion Group, Arkansas Biosciences Institute, Jonesboro, AR, October 12, 2007.

“Engineering vitamin C and taxanes levels in plants: An update” KA Lisko*, G Trujillo*, G Wilson*, M Belisle*, RS Harris*, F Crawford, J Yactayo*, F Bestoso*, and A Lorence.

18. INVITED (F Medina-Bolivar) 2007 Phytochemical Society of North America Annual Meeting, July 21-25, 2007, St. Louis, MO. “Thichloroethylene induces stilbenoid compounds and antioxidant activity in peanut roots”. F Medina-Bolivar, C Nopo-Olazabal, S Ganapathy, L Nopo-Olazabal, R Hannigan, K Redeker, A Lorence, C Purnell, RS Harris*, and S Simeon*.

19. INVITED, lecture for scholars of the NSF-funded Research Internships in Science of the Environment (RISE), Arkansas State University, Jonesboro, AR. Topic: “The importance of networking”. July 24, 2007.

20. Oral presentation ( G Wilson), McNair Scholars 2007 Summer Research Symposium, July 25-26, 2007, Jonesboro, AR “Glucuronolactonase, a gene family encoding enzymes involved in vitamin C biosynthesis and degradation”. GA Wilson*, G Trujillo-Luján*, M Belisle*, and A Lorence.

21. KEYNOTE ADDRESS INVITED (C Cramer), June 25-29, 2007, XII National Congress of Biotechnology and Bioengineering, Mexican Society of Biotechnology and Bioengineering, Morelia, Mexico. “Biotechnology at the interface of agriculture and medicine”. C Cramer, M Dolan, A Lorence, F Medina-Bolivar and P Weathers.

22. INVITED (L Offenbach), 17th Annual World Symposium, International Food and Agribusiness Management Association, June 23-26, Parma, Italy. “Fruits and vegetable consumption among college students in Arkansas and Florida: food culture versus health knowledge” C Schroeter, L Offenbach and A Lorence. Nominated to Best Paper Award in Agribusiness Symposium.

23. INVITED, June 7, 2007, National Council of Science, Technology and Innovation (Secretaría Nacional de Ciencia, Tecnología e Innovación, SENACYT) and Institute of Advanced Scientific Reseach and High Technology Services (Instituto de Investigaciones Científicas Avanzadas y Servicios de Alta Tecnología, INDICASAT). “Manipulation of the vitamin C content in plants: Implications for human health, agriculture and environment”. A Lorence.

24. Seminar, April 13, 2007, Plant Biotechnology Discussion Group, Arkansas Biosciences Institute, Jonesboro, AR. “An update in the science of vitamin C” G Trujillo*, G Wilson*, K Lisko*, RS Harris*, S Simeon*, J Yactayo* and A Lorence.

25. INVITED, February 12, 2007. University of Arkansas at Little Rock, Biosciences and Bioinformatics Spring Seminar Series, Little Rock, AR. “Engineering vitamin C levels in plants: New roles for an old molecule”. A Lorence.

26. INVITED, Dec 20, 2006. Symposium on Biological, Chemical Defense and Homeland Security, 2006 International Conference on Bio and Pharmaceutical Science and Technology (ICBPST), San Diego, CA, Dec 18-21, 2006. “Harnessing the potential of plant genomics in detection and remediation of explosives and chemical weapons” RS Harris*, T Moss, R Hannigan, and A Lorence.

27. Seminar, October 20th, 2006, Plant Biotechnology Discussion Group, Arkansas Biosciences Institute, Jonesboro, AR. “The role of ascorbate in coordinating growth and senescence in Arabidopsis thaliana: an update” A Lorence.

28. Seminar, October 5th, 2006, POI Aging Work Group at UAMS, Little Rock, AR. “The role of ascorbate in coordinating growth and senescence in Arabidopsis thaliana: an update” A Lorence.

29. INVITED, lecture to scholars of the NSF-funded Research Internships in Science of the Environment (RISE), Arkansas State University, Jonesboro, AR. Topic: “The importance of networking”. July 20, 2006.

30. INVITED, July 11, 2006. Phytochemical Society of North America Meeting, July 8-12, 2006, Oxford, MS. “Enhanced production of specialized metabolites in tobacco over-expressing an AP2-type transcription factor”. A Lorence, BJ Woffenden, J Martínez-Quintana*, L Nopo-Olazabal, CL Nessler, and F Medina-Bolivar.

31. Seminar, July 7, 2006, Plant Biotechnology Discussion Group, Arkansas Biosciences Institute, Jonesboro, AR. “What is an ORCA doing in my tobacco?” A Lorence.

32. Seminar, June 1st, 2006, POI Aging Work Group at UAMS, Little Rock, AR. “Role of ascorbate in coordinating growth and senescence in Arabidopsis thaliana” A Lorence.

33. Seminar, May 26, 2006, Plant Biotechnology Discussion Group, Arkansas Biosciences Institute, Jonesboro, AR. “Synopsis of Symposium: RNA Biology – Novel Insights from Plants” A Lorence.

34. INVITED, October 14, 2005 American Chemical Society Student Meeting, Arkansas State University, Jonesboro, Arkansas “Vitamin C, a master nutrient for humans and a crossroad in plant biochemistry” A Lorence.

35. INVITED, September 30, 2005 Department of Chemistry, University of Memphis, Memphis, TN “Vitamin C biosynthesis in plants, a tale of many routes” A Lorence.

36. INVITED (F Medina-Bolivar) 2005 Meeting of the Phytochemical Society of North America “Integrative Plant Biochemistry as We Approach 2010” July 30 – August 3, 2005, Salk Institute, CA “Over-expression of transcription factors to manipulate specialized metabolite biosynthesis” A Lorence, BJ Woffenden, M Smith, CL Nessler, and F Medina-Bolivar.

37. INVITED (CL Nessler), 2005 In Vitro Biology Meeting, June 5-7, 2005, Baltimore, MD “The vitamin C network – new branches in plant biochemistry” CL Nessler, A Lorence, BI Chevone and P Mendes.

38. INVITED, 2nd National Meeting of Chemistry of Natural Products, “Dr. Alfonso Romo de Vivar Romo”, May 25-28, 2005, Cocoyoc, Mexico “Manipulation of the metabolic network of vitamin C for the production of plants with enhanced properties” A Lorence, BI Chevone, P Mendes and CL Nessler.

39. INVITED INTERVIEW SEMINAR, May 16th, 2005. Clemson University, Clemson, SC. “Manipulating the vitamin C metabolic network for the nutritional and agronomical enhancement of plants” A Lorence.

40. INVITED INTERVIEW SEMINAR, April 21st, 2005. Arkansas Biosciences Institute (ABI), Arkansas State University (ASU), Jonesboro, AR. “Manipulating the vitamin C metabolic network for the nutritional and agronomical enhancement of plants” A Lorence.

41. INVITED INTERVIEW SEMINAR, April 14th, 2005 University of Texas – San Antonio (UTSA), San Antonio, TX “Manipulating the vitamin C metabolic network for the nutritional and agronomical enhancement of plants” A Lorence.

42. INVITED INTERVIEW SEMINAR, March 4th, 2005. Polytechnic University, Brooklyn, NY “Manipulating the vitamin C metabolic network for the nutritional and agronomical enhancement of plants” A Lorence.

43. AWARD ADRESS Arthur Neish Young Investigator Symposium Speaker, 2002 Annual Meeting,

Phytochemical Society of North America (PSNA). July 20-24, 2002, Mérida, México “Holes in the membranes: how allelochemicals in the morning glory family dispose of enemies?” A Lorence, R Villatoro-Vera*, and R Pereda-Miranda.

44. INVITED, Molecular Biology Seminar Series, CINVESTAV- Irapuato, México, March 20, 2002 “The relationship between ORCAs and the joy tree” A Lorence.

45. INVITED, CEIB, UAEM, Cuernavaca, México, December 13, 2001. “Metabolic engineering of medicinal plants” A Lorence.

46. INVITED, 1St Engineering Congress, Universidad Iberoamericana, Mexico City, México, September 20, 2001. “Applications of molecular biology and biotechnology” A Lorence.

47. INVITED, Morelos Delegation of the Mexican Society of Biotechnology and Bioengineering, Cuernavaca, México, October 22, 1999. “Introduction of insect-resistant corn in Mexico”. A Lorence and R. Quintero.

48. INVITED, Centro de Investigación Biomédica del Sur/IMSS, Xochitepec, México, October 21, 1999. “Evaluation of the socio-economical impact of the introduction of Bt corn to Mexico” A Lorence and R Quintero.

49. INVITED, Molecular Biology Seminar Series, CINVESTAV- Irapuato, México. July 9, 1999. “The mechanism of action of Bacillus thuringiensis Cry proteins: implications for the management of Bt corn in Mexico” A Lorence and R Quintero.

50. INVITED, International Symposium “Modern strategies for contamination control and development of clean technologies”, Instituto de Ecología, Boca del Río, México, March 11-13, 1996. “In search of novel and better bioinsecticides” A Lorence and R Quintero.

51. INVITED, 5th Week of Scientific Research, CONACYT and UAEM, Cuautla, México, April 1994. “Alternatives to chemical pest control”. A Lorence and R Quintero.

52. INVITED, V Congress of Biotechnology and Bioengineering, Puerto Vallarta, México, September 1993. “Basic elements for the development and diffusion of biotechnology in Mexico, a comparative analysis” A Lorence, RL Gonzalez, and JL Solleiro.

53. INVITED, Instituto de Investigaciones Económicas (UNAM), Instituto de Investigaciones Sociales (UNAM) and Departamento de Sociología (UAM-A), Mexico City, México, November 25-27, 1991. “Feasibility study of the production and commercialization of insect-resistant tomato seeds” A Lorence, and H Rojas.

Discussion Panels 1 INVITED, Lorence A, Benjamin E, and Schroer J, panelist who participated in the discussion

“The Minority Under-represented Experience as a Faculty Member” for students participating in the 2008 NSF-funded Research Internships in Science of the Environment (RISE), Arkansas State University, Jonesboro, AR, July 25, 2008.

Posters 1. 2009 Society for In Vitro Biology Annual Meeting, June 6-10, Charleston, SC. “DMSO

stimulates production of artemisinin and also suggesting that the sesquiterpene may function as a ROS sink in Artemisia annua” PJ Weathers, A Mannan , CZ Liu, MJ Towler, D Vail, and A Lorence.

2. Fall 2008 INBRE – Undergraduate Research Conference, University of Arkansas, November 7-8, 2008, Fayetteville, AR. “A holistic approach to understand the roles of vitamin C in plant physiology and development” J Yactayo-Chang*, G Trujillo*, SI Aboobucker*, K Lisko*, RS Harris*, A Parbatani*, S Kulkarni*, G Wilson*, J Radin*, W Suza, and A Lorence.

3. Fall 2008 INBRE – Undergraduate Research Conference, University of Arkansas, November 7-8, 2008, Fayetteville, AR. “Phytoremediation potential of plants with elevated vitamin C content” RS Harris*, G Wilson*, J Radin*, W Suza and A Lorence.

4. ABI 2008 Fall Symposium October 7, 2008, Little Rock, AR. “Identification and characterization of a functional L-gulono-1,4-lactone oxidase in Arabidopsis” S Aboobucker*, W Suza and A Lorence.

5. NSF EPSCoR Annual Meeting Poster Session, Little Rock, AR, October 6 2008. “Insect defense and recombinant protein production in plants in the realm of ascorbate metabolism” W Suza, G Medrano, J Yactayo-Chang*, A Parbatani*, J Underwood, V Srivastava, F Goggin, D Dolan and A Lorence.

6. Cotton Field Day, Judd Hill Foundation, August 28, 2008, Truman, AR. “Vitamin C is essential not only for human health, but also for cotton growth and stress tolerance” K Lisko*, RS Harris*, R Buchanan, and A Lorence.

7. Arkansas EPSCoR P3 Training Conference, August 20-22, Petit Jean, AR. “Leveraging Arabidopsis genetic resources to identify a functional glucuronolactonase” G Trujillo-Lujan*, G Wilson* and A Lorence.

8. Arkansas EPSCoR P3 Training Conference, August 20-22, Petit Jean, AR. “Study of ascorbic acid capacity in Nicotiana species” C Willis*, J Yactayo-Chang*, MC Dolan and A Lorence.

9. Arkansas EPSCoR P3 Training Conference, August 20-22, Petit Jean, AR. “Harnessing the power of vitamin C for enhancing human and plant health” K Lisko*, RS Harris*, F Crawford*, J Yactayo* and A Lorence.

10. 2nd Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE), August 6-8, 2008, Washington, DC. “Elevated vitamin C enhances growth, stress tolerance and phytoremediation potential in Arabidopsis” K Lisko*, RS Harris* and A Lorence. K Lisko won a Student Travel Award from NISBRE.

11. 2nd Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE), August 6-8, 2008, Washington, DC. “Leveraging Arabidopsis Genetic Resources to Identify a Functional Glucuronolactonase” G Trujillo-Lujan*, G Wilson* and A Lorence.

12. RISE Scholars 2008 Summer Research Symposium, August 7, 2008, Jonesboro, AR. “Study of Ascorbic Acid Capacity in the Nicotiana Species” C Willis*, J Yactayo-Chang*, MC Dolan and A Lorence.

13. RISE Scholars 2008 Summer Research Symposium, August 7, 2008, Jonesboro, AR. “Impact of introduction of vitamin C in transient recombinant RTB fusion protein expression” E Fawcett*, J Ayala, MC Dolan, and A Lorence.

14. Poster Competition, Departments of Biology and Biotechnology and Chemistry and Biochemistry, Worcester Polytechnic Institute, April 15, 2008, Worcester, MA. “Cloning and characterization of two putative glucuronolactonases from Arabidopsis thaliana involved in ascorbate degradation” M Belisle*, G Wilson*, G Trujillo* and A Lorence.

15. Fall 2007 INBRE – Undergraduate Research Conference, University of Arkansas, November 9-10, 2007, Fayetteville, AR. “Exploring the plasticity of the myo-inositol pathway to vitamin C in plants” G Trujillo*, G Wilson*, M Belisle*, S Imran-Aboobucker*, J Yactayo*, S Simeon* and A Lorence. G Wilson got a Travel Award from the Honors College at ASU.

16. Fall 2007 INBRE – Undergraduate Research Conference, University of Arkansas, November 9-10, 2007, Fayetteville, AR. “Harnessing the power of vitamin C for enhancing human and plant health” K Lisko*, RS Harris*, F Crawford*, J Yactayo* and A Lorence.

17. Einstein’s in the City 2 International Students Research Conference 2007, City College of New York, October 30-31, 2007, New York, NY. “Mustards for better human health and a cleaner environment” F Crawford*, J Yactayo-Chang*, S Vanderpool, and A Lorence. F. Crawford won Award to Best Undergraduate Poster.

18. ABI 2007 Fall Symposium October 23, 2007, Little Rock, AR. “Harnessing the power of vitamin C for enhancing human and plant health” K Lisko*, RS Harris*, F Crawford*, J Yactayo* and A Lorence.

19. ABI 2007 Fall Symposium October 23, 2007, Little Rock, AR. “Environmental contaminants, autoimmune disease and phytoremediation” KM Gilbert, B Pzybyla, N Pumford, T Han, J Fuscoe, L Schnackenberg, JC Dosss, LA Macmillan-Crow, A Lorence, F Medina-Bolivar, C Cramer, and SJ Blossom.

20. RISE Scholars 2007 Summer Research Symposium, August 9, 2007, Jonesboro, AR. “Searching for the “C” in mustards” F Crawford*, J Yactayo-Chang*, S Vanderpool, and A Lorence.

21. Arkansas Bioinformatics Society (ARBIOS) Symposium: Building Careers in Bioinformatics, Arkansas State University, Jonesboro, AR, April 19-21, 2007. “Glucuronolactonase, a gene family encoding enzymes involved in vitamin C biosynthesis and degradation” G Wilson*, J Martínez-Quintana*, and A Lorence. G Wilson received Award for Best Undergraduate Poster.

22. 21st National Conference on Undergraduate Research (NCUR), April 12-14, Dominican University of California, San Rafael, CA. “Vitamin C biosynthesis in mustard species”. J

Uwase*, G Wilson*, J Martínez-Quintana*, S Simeon*, S Hill*, S Vanderpool, and A Lorence.

23. Pittsburgh Conference (Pittcon 2007) Meeting, February 25 – March 1, 2007, Chicago, IL “HPTLC method for simultaneous cellular redox and energy state determination of plant samples” S Simeon*, R Hannigan, J Martínez-Quintana*, F Medina-Bolivar, and A Lorence.

24. Fall 2006 INBRE – Undergraduate Research Conference, University of Arkansas, November 3-4, 2006, Fayetteville, AR. “Screening of Arabidopsis thaliana knockout lines looking for genes encoding glucuronolactonase, the third enzyme in the myo-inositol pathway to ascorbate” G Wilson*, J Uwase*, S Simeon*, J Martínez-Quintana*, and A Lorence.

25. Fall 2006 INBRE – Undergraduate Research Conference, University of Arkansas, November 3-4, 2006, Fayetteville, AR. “Elevated foliar vitamin C content confers plants tolerance to stresses” KA Lisko*, J Martínez-Quintana, B Jullian*, M Vaughan*, BI Chevone, CL Nessler, and A Lorence.

26. ABI 2006 Fall Symposium, October 25, 2006, Little Rock, AR. “ORNA: a master regulator of genes in the tobacco plant” A Lorence, BJ Woffenden, J Martinez-Quintana*, L Nopo-Olazabal, CL Nessler and F Medina-Bolivar.

27. ABI 2006 Fall Symposium, October 25, 2006, Little Rock, AR. “Vitamin C biosynthesis in mustard species” J Uwase*, G Wilson*, J Martínez-Quintana, S Simeon*, S Hill, S Vanderpool, and A Lorence.

28. ABI 2006 Fall Symposium, October 25, 2006, Little Rock, AR. Seeding success… from people to products” C Cramer, E Hood, M Dolan, and A Lorence.

29. Society for Advancement of Chicanos and Native Americans in Science Meeting, October 26-28, 2006, Tampa, FL “Screening of Arabidopsis thaliana knockout lines looking for genes encoding glucuronolactonase, the third enzyme in the myo-inositol pathway to ascorbate” G Wilson*, J Uwase*, S Simeon*, J Martínez-Quintana*, and A Lorence.

30. Society for Advancement of Chicanos and Native Americans in Science Meeting, October 26-28, 2006, Tampa, FL “Elevated foliar vitamin C content confers plants tolerance to stresses” KA Lisko*, J Martínez-Quintana*, B Jullian*, M Vaughan*, BI Chevone, CL Nessler, and A Lorence.

31. International Symposium on High Performance Thin Layer Chromatography, October 9-11, 2006, Berlin, Germany ”HPTLC as a tool to rapidly assess the elicitor responsiveness of hairy roots cultured in the Liquid LabTM reactor” F Medina-Bolivar, L Nopo-Olazabal, S Simeon*, K Shelton, J Condori, R Hannigan, and A Lorence.

32. RISE Scholars 2006 Summer Research Symposium, August 11, 2006, Jonesboro, AR. “Vitamin C biosynthesis in mustard species” J Uwase*, G Wilson*, J Martínez-Quintana*, S Simeon*, S Hill*, S Vanderpool, and A Lorence.

33. McNair Scholars 2006 Summer Research Symposium, July 26-27, 2006, Jonesboro, AR “Screening of Arabidopsis lines looking for genes encoding glucuronolactonase, the third enzyme in the myo-inositol pathway to ascorbate” G Wilson*, J Uwase*, S Simeon*, J Martínez-Quintana*, and A Lorence.

34. Phytochemical Society of North America Meeting, July 8-12, 2006, Oxford, MS “Elicitation and secretion of sesquiterpenes in hairy roots cultured in the Liquid LabTM bioreactor”. L Nopo-Olazabal, S Simeon*, R Hannigan, A Lorence, and F Medina-Bolivar. S Simeon won a Student Travel Award from PSNA.

35. 16th Penn State Symposium in Plant Physiology, May 18-20, 2006, State College, PA “Myo-Inositol oxygenase and D-glucuronic acid reductase, the two first enzymes in a new route to vitamin C formation in plants” A Lorence, A Rogers*, J Martínez-Quintana*, J Robinson, W Zhang, P Mendes, BI Chevone, and CL Nessler.

36. 2005 Fall Symposium, Arkansas Biosciences Institute, September 28-29, 2005, Little Rock, AR. “Myo-inositol oxygenase and glucuronic acid reductase, the two first enzymes in a new

route to vitamin C formation in plants” A Lorence, A Roger*, J Robinson*, W Zhang, P Mendes, B Chevone, and CL Nessler.

37. 1st Gordon Conference in Plant Metabolic Engineering, July 10-15, Tilton, NH “A novel F-box gene, osf1, regulates leaf ascorbate in Arabidopsis and alters ozone sensitivity” W Zhang, A Lorence, CL Nessler, and BI Chevone.

38. 37th Air Pollution Workshop, April 25-28, Banff, Alberta, Canada “A novel F-box gene, osf1, regulates leaf ascorbate in Arabidopsis and alters ozone sensitivity” W Zhang, A Lorence, CL Nessler, and BI Chevone.

39. 21st Annual Research Symposium and Exposition of the Graduate Student Assembly of Virginia Tech, March 23, 2005. Blacksburg, VA “Metabolic engineering of specialized metabolite biosynthesis, a novel approach for the discovery of human therapeutics” M Smith, B Woffenden, CL Nessler, A Lorence, and F Medina-Bolivar.

40. 15th International Conference on Arabidopsis Research. July 11-14 2004, Berlin, Germany “Contribution of the myo-inositol oxygenase (miox) gene family of Arabidopsis thaliana to ascorbate biosynthesis” A Lorence, J Robinson*, BI Chevone, P Mendes, and CL Nessler.

41. 15th International Conference on Arabidopsis Research. July 11-14 2004, Berlin, Germany “Identification and characterization of a putative glucuronic acid reductase in Arabidopsis thaliana” A Lorence, A Rogers*, P Mendes, W Zhang, BI Chevone, and CL Nessler.

42. 2004 International Congress on Natural Products Research. July 31-August 4 2004, Phoenix, AZ “Convolvulaceous resin glycosides induce non-selective pore formation in cell membranes” RA Villatoro-Vera*, M. Bah, A Lorence, and R Pereda-Miranda.

43. 2003 Symposium, Undergraduate Summer Research Internship of the Multicultural Academic Opportunities Program. Summer, 2003, Blacksburg, VA “Genetic engineering of an alternative vitamin C pathway in Arabidopsis” J Robinson*, A Lorence, BI Chevone, P Mendes, and CL Nessler.

44. First International Congress on Plant Metabolomics, April 7-11 2002, Wageningen, The Netherlands “Production of camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots” A Lorence, F Medina-Bolivar, and CL Nessler.

45. 42nd Annual Meeting of the American Society of Pharmacognosy “Exploring Natural Products from Latin American Biodiversity”, July 14-18 2001, Oaxaca, México “Camptothecine production by Camptotheca acuminata cell suspensions” JS Angeles*, ML Villarreal, R Quintero, R Pereda-Miranda, and A Lorence.

46. First Congress of Principal Investigators of Research Projects in Applied Biological Sciences, CONACYT, Acapulco, México “Tranformation of Camptotheca acuminata cell cultures for the production of camptothecin, a terpene with anticancer and antiretroviral activities” A Lorence, JS Angeles*, ML Villarreal, CL Nessler, and R Quintero.

47. Perspectives and Limitation of Biotechnology in Developing Countries, January, 24-28, 2000, San José, Costa Rica. “Camptothecine production by Camptotheca acuminata cell line cultures, a case of study of economic feasibility”. JS Angeles*, R Quintero, and A Lorence.

48. X Week of Scientific Research, UAM-X, September 27 – October 1st, 1999, Mexico City, México “Technological innovation in Mexican agriculture and agroindustry” JL Solleiro, C Del Valle, I Nuñez, H Hernández, R López, R Calderón, A Lorence, R Castañón, and G Pérez-Jerónimo.

49. 30th Annual Meeting SIP Banff' 97, Society for Invertebrate Pathology, August 24-29 1997, Banff, Alberta, Canada "Phylogenetic and functional analysis of the Bacillus thuringiensis insecticidal crystal protein family" A Bravo, A Lorence, J Sánchez, H Flores, L Güereca, and ME Nuñez.

50. 12th World Congress on Animal, Plant and Microbial Toxins, International Society on Toxinology. September 21-26, 1997, Cuernavaca, México."Is aminopeptidase N the

receptor of Cry1Ac δ-endotoxin in Trichoplusia ni midgut?" A Lorence, A Darszon, and A Bravo.

51. 12th World Congress on Animal, Plant and Microbial Toxins, International Society on Toxinology. September 21-26, 1997, Cuernavaca, México "The insecticidal crystal protein family from Bacillus thuringiensis" A Bravo, A Lorence, J Sánchez, H Flores, L Güereca, and ME Nuñez.

52. XXI National Congress of Biochemistry, November 3-7, 1996, Manzanillo, México “Ionic channels formed by the Cry1Ac toxin in presence of its receptor in black lipid bilayers” A Lorence, J Sánchez, A Darszon, and A Bravo.

53. XX International Congress of Entomology. August 25-31, 1996, Florence, Italy "Functional and phylogenetic studies of the pore formation domain from the Bacillus thuringiensis delta-endotoxins" A Bravo, A Lorence, J Sánchez, and ME Nuñez.

54. Third International Workshop on Pore-Forming Toxins, September 26-28, 1996, Mainz, Germany “Pore formation of the Bacillus thuringiensis Cry1Ac toxin in presence of the Trichoplusia ni toxin-receptor in planar lipid bilayers” A Lorence, J Sánchez, A Darszon, and A Bravo.

55. XX National Congress of Biochemistry, SMB, October 30, November 4, 1994, Zacatecas, México “Permeability changes on Spodoptera frugiperda BBMV caused by Bacillus thuringiensis δ-endotoxins” A Lorence, A Darszon, R Quintero, and A Bravo.

56. International Cooperation for Development of Biotechnology Conference organized by the National Steering Committee for Biotechnology, the Chief Scientist Ministry of Industry and Trade, the Ministry of Science and the Arts, the Israel Center for R&D (MATIMOP), the Israel Export Institute and the Rashi Foundation, October 30 – November 3, 1994, Jerusalem, Israel “Cry toxins induce an increase in cation membrane permeability involving ion channels in BBMV containing functional receptors” C Díaz, A Lorence, A Darszon, A Liévano, R Quintero, and A Bravo.

57. Second Meeting of the Mexican Society of Cell Biology, October 5-7, 1994, Mexico City, Mexico “Effects of Bacillus thuringiensis δ-endotoxins on the permeability of Spodoptera frugiperda brush border membrane vesicles” A Lorence, A Darszon, R Quintero, and A Bravo.

58. VIth International Colloquium on Invertebrate Pathology and Microbial Control y IIth International Conference on Bacillus thuringiensis, Society for Invertebrate Pathology (XXVIIth Annual Meeting). August 28 – September 2, 1994, Montpellier, France “Effects of Bacillus thuringiensis δ-endotoxins on the permeability of Spodoptera frugiperda midgut brush border membrane vesicles” A Lorence, A Darszon, R Quintero, and A Bravo.

59. Academic Meeting, X Anniversary of the Graduate Program in Biotechnology, CCH/UNAM, June 2-3, 1994, Mexico City, México “Design of a detection system of new Bacillus thuringiensis δ-endotoxins” A Lorence, A Darszon, R Quintero, and A Bravo.

60. Second Workshop on Pore-Forming Toxins. September 29 - October 2, 1993, Mainz, Germany. “Fluorometric assay of potential changes of Spodoptera frugiperda midgut brush border membrane shows that δ-endotoxin from Bacillus thuringiensis induces cation selective pore formation” A Lorence, A Darszon, R Quintero and A Bravo.

61. First Meeting of the Mexican Society of Cell Biology, June 14-16, 1993, Mexico City, México “Design of a detection system for new Bacillus thuringiensis δ-endotoxins based on changes in ion transport of brush border membrane vesicles” A Lorence, R Quintero, A Darszon and A Bravo.

62. The Ninth International Biotechnology Symposium, American Chemical Society. August 16 – 21, 1992, Crystal City, VA “Biotechnology for the development of Mexico” JL Solleiro, RL González, A Lorence, and G Gómez.

63. IV National Congress of Biotechnology and Bioengineering, SMBB, September 8-12, 1991, Mexico City, México “Comparative kinetic study of Candida utilis and Saccharomyces

cerevisiae cultures in different carbon sources” A López-Baca, M Trejo-Loyo, A Lorence, and J Gómez.

64. II Week of Experimental Biology, Universidad Autónoma Metropolitana, Iztapalapa, May 6-9, 1991, Mexico City, México “Effect of the carbon source concentration in the biochemistry and physiology of Saccahromyces cerevisiae biomass production” A Lorence, A Medina, M More, T Roldán, and J Gómez.

Attention of the media to my research Newspapers, magazines, and newsletter articles

1. “Highlights in Research and Sponsored Programs”, 2007-2008 Report, Arkansas State University Jonesboro, a picture of myself and one of my PhD students was chosen to illustrate this article in page 12 of this annual report.

2. “ABI Faculty Attend World In Vitro Congress”, “P3 Symposium” “Arkansas EPSCoR P3 Seed Grants” and “2008 Arkansas NSF EPSCoR Annual Conference”, these short articles highlight conferences I have presented, and proposals I have gotten funding for. Arkansas EPSCoR, Volume 1, Fall/Winter 2008.

3. “CSI: ASU” A photo highlighting Dr. Maureen Dolan and my participation at the CSI Summer camp was published in this article. Voices, the Magazine of ASU Alumni Association- Fall 2008.

4. “ASU researchers study nanoparticles and their effects in the environment” by Jennifer Bouldin. The Jonesboro Sun, October 5th, 2008.

5. “New science program designed to peak interest” by David Pierce, The Osceola Times, September 25, 2008. This article describes the work that Shea Harris, one of my MSc students has been doing by teaching science to 4th and 5th grade students.

6. “Lisko receives Student Travel Award”, article describing the award winning abstract that Katherine Lisko, one of my students received from the NIH-INBRE. The Grand Prairie Herald, August 27, 2008.

7. “A better understanding: ABI research seeks to find solutions to environmental concerns” by Susan O’Connor. Jonesboro Occasions magazine, April 2008. Article describing the research my group is doing in the area of phytoremediation.

8. “The power of green”. My photo was chosen to be included in recruiting materials designed by ASU to highlight research carried out at various academic departments in plant biotechnology. AY Magazine, Volume XIX, Number 12, April 2008. Also published in the Jonesboro Occasions magazine.

9. “Visitors from Arkansas Biosciences Institute” by Dr. Rosa Buxeda. The visit Dr. Pamela Weathers and I paid to the University of Puerto Rico campus Mayagüez was highlighted. Newsletter of the Industrial Biotechnology Program, UPR-Mayagüez, December 2007.

10. “New path for vitamin C production can improve crop values” by Siddique Imran. The Jonesboro Sun, November 11, 2007. S. Imran is one of the PhD students of my group.

11. “Research at A-State gets $9 million boost” by Susan O’Connor. Lead story (picture of my group in the front page) of the Jonesboro Sun, September 3rd, 2007.

12. “Biosciences board tours ASU campus” by Sherry F. Pruitt. Lead story (my picture in the front page) of The Jonesboro Sun, August 1st, 2007.

13. “2006 Proves to be year of achievements for A-State” by Aldemaro Romero, my research mentioned in this article published by the Jonesboro Sun, December 31, 2006.

14. “A-State teaching students how to investigate crime scenes” by Sherry F. Pruitt. Lead story (my picture in the front page) of The Jonesboro Sun, July 1st, 2006.

15. My research program was chosen by Dr. Elizabeth Hood, Associate Vice Chancellor for Research and Technology Transfer to represent ASU in the American Association of State Colleges and Universities, July 2006.

16. “ABI reaches out to future leaders” by Sherri F. Pruitt. My participation in the ABI/ASU Outreach Program is highlighted. The Jonesboro Sun, June 20, 2006.

17. “Biosciences Center researchers optimistic about work in plants” by Sherry F. Pruitt. Lead story of The Jonesboro Sun, March 12, 2006.

18. “Biosciences director describes research” by Grover Welch. The Jonesboro Sun, January 19th, 2006.

19. Interview for “The Herald” (ASU Newspaper), September 15th 2005, Jonesboro, AR. 20. “The Arkansas Biosciences Institute” by Tom Moore. Arkansas Agriculture, 2005, Vol. 3,

Issue 1, p. 15-18. 21. Book I co-edited: “Recombinant Gene Expression. Reviews and Protocols” featured at

Virginia Tech Magazine, 2004, Vol. 27, No. 1 (section books by alumni, faculty and staff). ASU press releases, University Communications 1. “Drs. Cramer, Hood, Lorence participate in symposium” October 29, 2008 2. “Dr. Lorence serves as invited speaker at conference” October 10, 2008 3. “Dr. Lorence serves as advisor, co-author” August 11, 2008 4. “ASU’s Lisko receives INBRE student travel award for biomedical research work”, August 7,

2008 5. “Dr. Lorence Receives Grants”, August 2008 6. “Dr. Lorence speaks, initiates collaborative agreement” July 7, 2008 7. “ABI faculty attend, present at World Congress on In Vitro Biology” July 2, 2008 8. “Convocations of Scholars Award – Dr. Lorence” April 14, 2008 9. “ASU professors secure National Science Foundation grant for recruiting minority students”

November 12, 2007 10. “Gov. Beebe releases funds for EPSCoR projects” October 22, 2007 11. “Dr. Medina-Bolivar speaks at phytochemical conference” August 28, 2007 12. “ABI director gives keynote presentation in Mexico” July 16, 2007 13. “Dr. Lorence reviews and presents in Panama” June 13, 2007 14. “Medicinal plants expert to present biotechnology conferences at ASU” October 27, 2006 15. “Medical plants expert to present conferences” October 25, 2006 16. ”Dr. Argelia Lorence selected as ‘featured mentor” October 23, 2006 17. “Dr. Rachel Mata to speak in ABI seminar series” October 16, 2006

TV appearances 1. “ABI”, my students and research highlighted during the interview to Dr. Carole Cramer,

Executive Director of ABI. Aired on August 1st 2008 at the KAIT TV 8, local TV station, Jonesboro, AR.

2. The “CSI Summer Camp 2006” was the lead story on Monday June 26, 2006 of KAIT TV 8, local TV station, Jonesboro, AR.

3. Participant of the televised panel discussion entitled: “Clash of the Minorities”. Event organized as part of the Hispanic Heritage Week Celebration, Arkansas State University, TV Studio at the College of Communications Building. September 14th 2005, Jonesboro, AR.

4. TV and radio interview: “Biotechnology in Mexico”. TV and Radio Show entitled: “Detrás de la Noticia con Ricardo Rocha”, Grupo IMER Radio 660 AM and 94.5 FM and Cable TV. Guesses: Drs. Argelia Lorence and Enrique Galindo. November 10, 2001, Mexico City, México.

Radio interviews

“Vitamin C and aging”, interview aired on November 6, 2006 at KASU. Papers published in newspapers 1. “ASU team seeks keys to aging process” by Argelia Lorence, The Jonesboro Sun, April 30,

2006. 2. “The Monarch Butterfly and Genetically Modified Corn” by Paulina Balbás and Argelia

Lorence, La Jornada - Investigación y Desarrollo, December, 2001. Advisory activities Current (Primary Advisor) Lab technicians Gwendolyn Wilson February 2009 to date Jessica Yactayo-Chang March 07 to January 2009 Shannon Hill (part time) September 05 to December 06 Javier Martínez-Quintana January 06 to February 07 Graduate students Guillermo Trujillo PhD-Molecular Biosciences January 07 to date Siddique I Aboobucker PhD-Molecular Biosciences August 07 to date Katherine Lisko PhD-Molecular Biosciences August 08 to date Scott Simeon MS-Chemistry January 06 to June 08 Rodney Shea Harris MS-Environmental Sciences January 07 to date Shashank Kulkarni MS-Chemistry August 08 to date Jessica Yactayo-Chang MS-Chemistry January 2009 to date Arzoo Parbatani* MS-Chemistry May-October 2008 * co-advised in collaboration with Dr. Maureen Dolan Baccalaureate students Katherine Lisko BS-Forensic Science January to August 08 Gwendolyn Wilson BS-Biology May 08 to January 09 Undergraduate students Katherine Lisko BS-Forensic Science October 05 to December 07 Gwendolyn Wilson BS-Biology August 06 to May 08 Casey Robinson BS-Chemistry August to September 07 Hillary Colvard BS-Chemistry January to February 07 Rodney Shea Harris BS-Biology July to December 06 Jonathan Radin BS-Chemistry Summer 08 to date Summer interns Gwendolyn Wilson McNair Scholar ASU-Biology Summers 06 and 07 Jeannette Uwase RISE Scholar Ivy Tech CC Summer 06 Melinda Belisle WPI-Scholar Worchester May to October 07 Polytechnic Institute Fayeann Crawford RISE Scholar Brooklyn Summer 07 College of CUNY Emily Fawcett* RISE Scholar St Mary’s Summer 08

College, MD Corinna Willis* RISE Scholar Lincoln Univ. Summer 08 MO *co-advised in collaboration with Dr. Maureen Dolan Visiting scholars (main advisor) Federica Bestoso University of Genova PhD candidate July to August 07 (Italy) Bioengineering Guillermo Trujillo International Potato BS Biology Oct. to December 06 Center (Peru) In collaboration with Drs. Gregory Phillips and Helen Miller

Audrei Nisio State University of BS-Agronomy July to December 06 Ponta Grossa (Brazil) In collaboration with Dr. Maureen Dolan Aydin Akbudak UA-Fayetteville PhD July 21-25, 2008 High school student Jonathan Radin Jonesboro High School Summer 06 to May 08 Committee Member (current and past)

USA Alejandra Ratti ASU PhD-EVS February 07 to date Anindita Sengupta ASU PhD-EVS January 2009 to date Allison Asher ASU MSc-EVS October 07 to date

Mexico Ashutoshi Sharma CEIB/UAEM PhD- Biotechnology December 08 to date

Yeni Santos Mendoza CINVESTAV MSc-Biochemical Eng June 08 to date Janet María León M CEIB/UAEM MSc-Biotechnology June 06 -February 08

External reviewer of a PhD thesis Sonia Malik, PhD Candidate, Guru Nanak Dev University, India (2008) As an Assistant Professor (Mexico) 1999-2003 Primary Advisor Student Major Degree Year granted Ana Lilia Mercado-Sánchez Chemical Engineering BS 2002 Alejandra Rueda-Deagüeros Chemistry BS 2003 1998-2003 Committee Member Student Degree Period Year granted Nubia C Moreno-Sarmiento MSc 1998-1999 March 99 Rubí Hernández-Rubio MSc 1998-1999 Sep 99 Alfredo Regalado-Páramo MSc 1998-2001 Aug 01 Víctor H Chávez-Tovar MSc 2001-2003 July 03 María Alejandra Brito-Cruz MSc 2000-2002 Dec 03 Ricardo Villatoro-Vera PhD 1999-2002 Deceased

Lucila Valdéz-Castro PhD 1999-2003 June 03 As a Post-doctoral Research Associate April 02 – July 05

Supervisor of lab technicians, graduate students, undergraduate students and summer interns in Craig Nessler laboratory at Virginia Tech

Lab technicians Martha Vaughan March to August 05 Amy Vance November 02 to February 05 Karen Stump April to July 02

Graduate students Jessica Radzio MS 2002 to 2003 Michelle Raymond MS 2002 to 2004 Visiting scholars Berangère Jullian BS-Bioinformatics April to August 05 Universite D’Auvergne (France) Undergraduate students Catherine O’Mara March 04 to August 05 James A Gardner August 04 to August 05 Joseph D Wood January to August 05 Jennifer A Witten March to August 05 Thomas R Evans April to August 05 Amber M Rogers September 02 to May 05 Martha Vaughan September 03 to February 05 Melanie Turner May 02 to January 05 Katherine Mitchell May 02 to July 04 Jefferson Stroud May 03 to February 04 Courtney Rudd April 02 to April 03 Kristos Vaughan February to December 04 David Harbourt February to August 04 Jessica Caldwell September to December 02 Rebecca Miller August to December 02 Summer Interns (Minority students, Multicultural Academic Opportunities Program, MAOP) Janeth Carranza Prairie View A&M Summer 04 Jon Robinson Cornell University Summer 03 Deanna Conquest Delaware State University Summer 02 High school students Laura Nessler Blacksburg High School Summer 05 August 00 – June 01 Supervisor of lab technician, and undergraduate students in Craig Nessler laboratory at

Virginia Tech Lab technician

Jocelyn Fraga-Müller October 00 to June 01 Undergraduate student workers Jessica Radzio August 00 to June 01 Scott McFarlain October 00 to June 01 Teaching experience At ASU I taught Molecular Genetics and Genomics (MBS 6243; 12 students), fall 2008. I taught Advance Biochemistry (CHEM 4913; 2 students), Department of Chemistry and

Physics, ASU, January to May 2008. I developed the syllabus of Advanced Biochemistry (CHEM 4913), Department of Chemistry

and Physics, ASU, fall 2007. I taught the second half of Molecular Genetics and Genomics (MBS 6243; 11 students), fall

2007. Dr. Soo Ahn taught the first half. I participated in the 2007 CSI Camps I and II, Arkansas State University, June 18-29,

Jonesboro, AR. I developed a class and hands-on module on molecular speciation of cultivars of Arabidopsis.

I taught a section of Topics in Molecular Biosciences (MBS 7123, 6 students), ASU, March 13-29, 2007.

I taught Making Connections. PSCH 1913 sections 001 and 003 (24 students), Department of Chemistry and Physics, ASU, fall 2006.

I taught Topical Seminar in Phytoremediation ( ESCI 7121-002; 6 students).The co-instructors were Drs. Robyn Hannigan, Fabricio Medina-Bolivar, Jennifer Bouldin, David Gilmore, and Kelly Redeker. ASU, fall 2006.

I taught Research in Chemistry: Phytoremediation (CHEM 427V 005 to Rodney S. Harris, undergraduate). ASU, fall 2006.

I presented an invited lecture to Agriculture and the Environment (AGRI 4223), course led by Dr. William Baker “Genetically modified plants: issues and opportunities”. ASU, November 14, 2006.

Co-organized 1st International Workshop on Hairy Roots: Exploiting Plant Metabolism for Agriculture and Medicine in collaboration with Dr. Fabricio Medina-Bolivar. Undergraduate and graduate students were able to get credit for enrolling in the workshop and attending additional sessions of classes and approving a test and final project. The name of the classes and corresponding codes are: “Biotechnological applications of hairy root cultures” BIOL 4441 (undergraduates) and BIOL 5441 (graduates), also “Exploiting Plant Metabolism for Agriculture and Medicine” ESCI 7121 (graduates).

I participated in the 2006 CSI Advanced Camp, Arkansas State University, June 26-30, Jonesboro, AR. I developed class and hands-on module on thin layer chromatography of plant pigments. The CSI Camp was the lead story on Monday June 26 of KAIT TV 8 and also the lead story at the front page of The Jonesboro Sun on July 1st, 2006.

I developed the syllabus of Molecular Genetics and Genomics (course 6243), Molecular Biosciences Graduate Program, ASU, to start on fall 2007.

I presented an invited lecture for McNair Scholar: “Studying and manipulating vitamin C levels in plants”.

Arkansas State University, Jonesboro, AR, April 17, 2006. Past

September 28-30, 2004. Invited lectures in the advance course: Advanced Plant Physiology and Metabolism I. Fall 2004. PPWS/HORT 5524. Lecture: “Genome Organization and Expression”. Virginia Tech.

March 4, 2004. Invited lecture in the advanced course: Topics in Molecular, Cell Biology and Biotechnology Spring 2004. ALS/BCHM/BIOL/PPWS Departments. Lecture: “Metabolic Engineering of Plant Antioxidants”. Virginia Tech.

August – December 2001, January – July 1999. Co-lecturer for the advanced course in Molecular Biology for graduate students, CEIB/UAEM.

September 19, 2001. Lecturer of course “Applications of Genetic Engineering in Health, Agriculture, Food Production and Protection of the Environment” for high school Biology teachers. AgroBio México.

August 21, 2001. Co-lecturer for the workshop “Teaching Methodologies, Genetics and Environmental Impact” for high school Biology teachers. Dirección de Educación Media Superior/UAEM.

July – August 2001. Co-lecturer for the introductory course in Molecular Biology for freshman Biology students, Facultad de Biología/UAEM.

May – September 1999. Lecturer for the course “Mexican Biotechnology Today” for graduate students. CEIB/UAEM.

January 1999. Co-lecturer for the advanced course “Introduction to Modern Genetics and Biodiversity” for high school Biology teachers. Coordinación del Nivel Medio Superior/UAEM.

July- September 1998. Lecturer for the course “Biotechnology and Its Applications” for graduate students. CEIB/UAEM.

August 10-15, 1998. Co-lecturer for the course “Advanced Topics of Modern Biology” for Biology high school teachers. Coordinación del Nivel Medio Superior/UAEM.

February – July 1999, August 1998 – January 1999, February – July 1998. Lecturer for the basic course in Physicochemistry for Biology Majors, Facultad de Biología/UAEM.

November 3-7, 1997. Co-lecturer for the Theoretical-Practical Course “Biotechnology of Bacillus thuringiensis”. Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL).

October 3-14, 1994. Co-lecturer for the 5th Advanced Course of “Biotechnological Processes: Biotechnological Applications in Integrated Pest Management for Crops”, Instituto de Biotecnología (IBT/UNAM), Biotechnology Program for Latin America and the Caribbean/UNIDO, and CEIB/UAEM.

Manuscript reviewer for refereed journals African Journal of Biotechnology Biochemical Engineering Journal Biotechnology Progress Engineering in Life Sciences In Vitro Plant

International Journal of Experimental Pathology Journal of Agricultural and Food Chemistry Journal of Plant Physiology Nanomedicine Phytochemistry Plant Cell Reports Plant Physiology and Biochemistry Transgenic Research Trends in Plant Sciences

ARS/USDA (reviewed paper submitted to Phytochemistry)

Grant proposal reviewer External Evaluator Ad-Honorem, Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Panama, Panama (March 2007 to date) National Science Foundation, Integrative Organismal Systems – Physiological and Structural System Cluster (2009). National Science Foundation, Integrative Plant Biology - Functional and Regulatory Systems Cluster (2006). National Science Foundation, Division of Biological Infrastructure – Research Experience for Undergraduates Sites (2005). BARD, the United States - Israel Binational Agricultural Research & Development Fund (2004).

Universidad Autónoma del Estado de Morelos, Cuernavaca, México (1997). Service Service to Arkansas State University

Service to the University - Member of the Molecular Biosciences (MBS) Graduate Program Committee, December

2008 – present. - Member of the Arkansas State University Biosafety Committee (IBC), June 2006 –

March 2009. - Member of the Faculty Research Awards Committee, September 2006 to date. - Secretary (elected) of the Faculty Research Awards Committee, September 7, 2007 to

2008. Re-elected for next academic year. - Collaborator with Dr. Marty Allen and Lenore Shoults in organizing celebration of “Día de

Muertos” (Day of the Death) at the ASU Museum, August 2007-November 2007; 350 people attended the event the night of November 2nd from 6 to 9 pm. Participation on this event on November 1st, 2008, 500 people attended the second event.

- Master of ceremony, at the “Convocation of Scholars 2006 Honors Banquet” of the College of Science and Mathematics, ASU, Jonesboro, AR, April 12, 2006.

- Coordinator of all First Year Experience (FYE) instructors of the College of Sciences and Mathematics, ASU, Fall semester 2006.

Service to the Arkansas Biosciences Institute - Member of Search Committee, Professor and Director of Molecular Biosciences

Graduate Program, Arkansas Biosciences Institute, January - August 2006. - Member of Search Committee, Post-doctoral Research Associate for the laboratory of

Dr. Robyn Hannigan, July – December 2007. - Member of Search Committee, Post-doctoral Research Associate for the laboratory of

Dr. Elizabeth Hood, January – February 2007. - Member of Search Committee, Post-doctoral Research Associate for the laboratory of

Dr. Elizabeth Hood, May – June 2008. - Chair and member of Search Committee, Post-doctoral Research Associate for my

laboratory (June-July 2008) - Member of Search Committee, Post-doctoral Research Associate for the laboratory of

Dr. Elizabeth Hood, July – August 2008. - My laboratory was selected as one of the highlights for the “ABI Board Tour” by Dr.

Carole Cramer, Executive Director of ABI, July 30, 2007.

- My laboratory was selected as one of the highlights for the “Legislative ABI Tour” by Dr. Carole Cramer, Executive Director of ABI, October 7, 2006.

- Participation on recruitment tour to Universidad de Puerto Rico - Río Piedras (San Juan, Puerto Rico) and Universidad de Puerto Rico - Mayagüez (Mayagüez, Puerto Rico) to bring students to the Molecular Biosciences PhD Program, Nov 28 to Dec 1st, 2007.

- Host of Dr. Michael Vickery. Dr. Vickery demonstrated and trained ABI faculty, staff and students in SmartCycler technology for real time detection of nucleic acids. December 12, 2006.

- On-site administrator of the Promega Freezer. This freezer serves several laboratories doing molecular biology at ASU (November 2005 – present).

- Helped design the Safety Training Form all ABI staff/students must fill out before they start doing experimental work within the facilities.

Service to the Department of Chemistry and Physics - Member of the Search Committee for an Assistant Professor in Analytical Chemistry.

Department of Chemistry and Physics, November 2008 to date. - Chair, Search Committee that selected a candidate for the Assistant Professor position

in Chemistry/Forensics. Department of Chemistry and Physics, August 2007 to May 2008.

- Main coordinator of the Advanced Biochemistry class, and consultant on the preparation of a proposal for a new Biochemistry Major.

- Member of the Search Committee for an Assistant Professor in Organic Chemistry. Department of Chemistry and Physics, August 2006 – January 2007.

- Member of the Search Committee of an Assistant Professor in Analytical Forensic/Environmental Chemistry, Department of Chemistry and Physics, August 2005 – January 2006.

- Main coordinator of content design and printing of brochures and posters to recruit students to both the undergraduate and the graduate programs in Chemistry, Department of Chemistry and Physics, ASU. Among other activities I searched for funds in the office of Dr. Glen Jones, gathered pictures from all colleagues and co-wrote wording for the brochure and poster in collaboration with Drs. John Pratte and Robyn Hannigan.

Outreach

I am one of the most active faculty members at leading tours of the ABI building. In multiple

cases in addition to showing the highlights of the four focus areas in which research concentrates at ABI, I have developed teaching materials (posters, flyers, installations, etc) and hands-on activities for visitors of various ages. Date and time School or affiliation # Students,

teachers or visitors Contact information

Tour/Demo

10/11/05 9:30 – 11:30 am

Craighead and Green Counties High School Honors Students

20 students Ford Mundy Tour: M Dolan, A Lorence Demo: D Rogers and L Kellim

10/17/05 2:00 – 3:00 pm

Journalism class 20 students Dr. Bonnie Thrasher

Tour: A Lorence No demo

10/24/05 6:00 – 7:30 pm

ASU Faculty Women Club

20 visitors Dr. Jenifer Rice-Mason


11/15/05 4:30 – 5:30 pm

Introduction to Biology Class, Paragould, AR

28 students Kendall Hood Tour: A Lorence No demo

12/05/05 Biochemistry I class 38 students/ Dr. Anne Grippo Tour: A Lorence

11:00 – 12:00 pm 1 teacher No demo 01/09/06 8:30 – 9:00 am

Dr. Kelly Redeker, University of Belfast, Ireland

1 visitor Dr. Robyn Hannigan


01/12/06 10:00 – 10:30 am

Dr. Darcey Wayment, Our Lady of the Lake University, TX



01/17/06 9:00 – 11:00 am

Bay High School ,10th grade

25 students N.D. Tour: A Lorence Demo: D Rogers and L Kellim

01/17/06 11:30 – 12:00 pm

Dr. Joseph Simeonsson, Advanced Monitoring, NC



01/18/06 9:30 – 10:00 am

Dr. Lateefah Stanford, Florida State University, FL



01/25/06 10:00 – 11:00 am

Drs. Helen Benes and Larry Cornett, University of Arkansas for Medical Sciences, AR

2 visitors Dr. Argelia Lorence


4/14/06 8:00 - 10:00 am

Jonesboro High School Interservice

30 teachers Laura Cremmens Tour: A Lorence and L Kellim No demo

4/20/06 9:00 - 11:00 am

Paragould High School Science Club, 9th-12th grades

27 students/ 2 teachers

Sharon Rondone Michelle Guinn

Tour: M Dolan and A Lorence Demo: D Rogers and L Kellim

5/09/06 9:00 - 11:00 am

Calico Rock High School, 11th-12th grades

23 students/ 3 teachers

Rebecca Koelling Tour: M Dolan and A Lorence Demo: D Rogers and L Kellim

6/09/06 11:50 - 12:00 pm

Lyon College Upward Bound Math and Science

22 students Jerrod Lockard Tour: A Lorence No demo

6/19/06 10:30 - 12:30 pm

CNHP Summer Health Day Camp Area, 9th – 10th grades

9 students/ 1 instructor

Judith Pfriemer Tour: M Dolan and A Lorence Demo: L Kellim

6/26/06 8:30 - 12:00 pm

Teachers touring industry 30 teachers Debby Rogers Tour: M Dolan, A Lorence, C Cramer Demo: D Rogers and L Kellim

07/13/06 4:30 - 5:30 pm

Drs. María Luisa Villarreal (Universidad Autónoma de Estado de Morelos, Mexico), Sandra Pitta (Fundación Pablo Cassará, Argentina), and Joel Cuello (University of Arizona)

3 visitors Dr. Argelia Lorence


10/07/06 1:00 - 3:00 pm

Legislative ABI Tour DEVELOPMENT OF NEW MATERIALS

20 visitors Dr. Carole Cramer Tour: A Lorence Progress on vitamin C metabolic engineering program

10/11/06 10:00 - 11:00 am

Dr. Wayne Landis, Washington State University

1 visitor Dr. Richard Grippo Tour: A Lorence No demo

10/12/06 11:00 – 12:00 pm

First Year Experience: Biological Science Class

20 students/ 1 teacher

Dr. Richard Grippo Tour: A Lorence No demo

10/13/06 2:15 - 3:15 pm

Master Gardener Advanced Training

50-60 guests Dr. Kim Pittcock Tour: M Dolan, J Hubstenberger, A Lorence, L Kellim,

and D Rogers No demo

10/17/06 9:30 – 10:15 am

Dr. Rachel Mata, Universidad Nacional Autónoma de México, Mexico

1 visitor Dr. Argelia Lorence

Tour: C Cramer and A Lorence No demo

10/23/06 11:00 - 12:15 pm

First Year Experience – Chemistry Major Class

25 students Dr. Argelia Lorence

Tour and demo: A Lorence

10/25/06 9:00 - 11:00 am

Armorel High School, 7th-12th grades gifted/talented

30 students Kelly Belew Tour: A Lorence Demo: L Kellim and D Rogers

11/02/06 10:00 – 11:00 am

Dr. Rodolfo Quintero, Universidad Autónoma Metropolitana campus Cuajimalpa, Mexico


Tour: C. Cramer and A Lorence No demo

11/11/06 9:00 - 3:00 pm

Women in Science and Technology Event, 5th-7th grades DEVELOPMENT OF NEW MATERIALS

6 groups, 7-15 students each

Dr. Maureen Dolan

Hands on activity “plant pigments fun and colors”

12/01/06 9:00 – 10:00 am

Dr. Rogelio Pereda-Miranda, Universidad Nacional Autónoma de México, Mexico



12/12/06 9:00 - 11:00 am

Armorel Elementary , 4th – 6th grades gifted/talented

30 students Kelly Belew Tour: A Lorence Demo: L Kellim and D Rogers

03/31/07 8:00 - 3:00 pm

Girls of Promise, 9th -11th grade DEVELOPMENT OF NEW MATERIALS

4 groups, 10 students each

Dr. Carole Cramer Hands on activity “Colors in food”

04/24/07 12:30 - 2:30 pm

Blessed Sacrament, 6th grade

21 students/ 1 teacher/4 parents

Bonnie Kline Hands on activity “Colors in food”

07/30/07 10:00 - 12:00 pm

Statewide ABI Board DEVELOPMENT OF NEW MATERIALS

20 visitors Dr. Carole Cramer Tour: A Lorence Progress on vitamin C metabolic engineering research program

8/13/07 11:00 - 11:30 am

ASU New Faculty 20 teachers Louis Scivally Tour: A Grippo and A Lorence No demo

09/05/07 9:00 – 10:00 am

Dr. Mario De Tullio, University of Bari, Italy



11/05/07 11:00 - 11:50 am

Human Genetics Class DEVELOPMENT OF NEW MATERIALS


Dr. Ron Johnson Tour: L Nopo, A Lorence, J Yactayo, G Medrano and M Dolan

11/13/07 12:30 - 1:45 pm

First Year Experience Class – Chemistry Majors DEVELOPMENT OF NEW MATERIALS

58 students Dr. John Pratte Tour: A Lorence Demo: M Dolan, J Yactayo and A Lorence

11/26/07 3:30 - 4:00 pm

Dr. Allyn Ontko, University of Wyoming, WY



12/11/07 10:00 - 10:40 am

Dr. Farhana Chowdhury, University of Tennessee, TN



12/13/07 4:00 – 5:00 pm

Dr. Mark Sabo, Salisbury College, NC



02/27/08 Dr. Margaret Allen 1 visitor Dr. Argelia Tour: A Lorence

11 am – 12 pm USDA, Stoneville, MS Lorence No demo 04/12/08 8:30 am - 3:00 pm

Girls of Promise, 9th -11th grade DEVELOPMENT OF NEW MATERIALS

3 groups, 12 students each

Dr. Carole Cramer Hands on activity “The Science and Fun of Fruits and Vegetables” A Lorence

05/01/08 12:30 – 2:30 pm

Blessed Sacrament, 6th grade


Bonnie Kline No tour Hands on activity “The Science and Fun of Fruits and Vegetables” A Lorence

05/14/08 9:00 – 10:00 am

Dr. Dimuth Siritunga, University of Puerto Rico Mayagüez



05/23/08 11:15 – 12 :00 pm

Leadership Jonesboro 75 visitors Dr. Carole Cramer Short demo vitamin C research program

09/17/08 10:30 – 11:30 am

Dr. Alan Tackett, UAMS 1 visitor Dr. Argelia Lorence


11/04/08 First Year Experience Class

39 visitors 1 teacher

Joy Trauth Tour: A Lorence, F Medina, R Buchanan, A Grippo No demo

11/20/08 Blessed Sacrament, 6th grade


Bonnie Kline No tour Hands on activity “Plant pigment chromatography” A Lorence, K Lisko, M Dolan

TOTAL # PEOPLE SERVED

1013

- Attended Field Day organized by the Judd Hill Foundation, September 1st, 2006. - Participated in the Career Fair, organized by Drs. Karen Yanowitz and Staria

Vanderpool as part of the Creating Student Investigators Institute Evening Program Series, ASU, Jonesboro, AR. Summers of 2007 and 2008.

- Participating in the Science Fair of Nettleton Junior High School, organized by Annette Holder, September 21, 2007. One of my students presented a poster and demo materials I developed to illustrate the importance of vitamin C for human and plant health.

Service to the Society for In Vitro Biology

- I co-organized a session on “New Strategies for the Production of Specialized Metabolites” and organized and served as convener of the session on “Biodiversity for Improving Human Health”, at the World Congress on In Vitro Biology Meeting, Society for In Vitro Biology, Tucson, AR June 14-18, 2008. My activities included inviting speakers, fund rising, coordinating travel arrangements, and hosting speakers during the meeting. I served as main negotiator of support from Fisher Scientific ($3000) to partially cover the expenses of speakers from Mexico (Drs. Maria Luisa Villarreal, and Ana Ramos Valdivia) and Brazil (Dr. Claudia Simoes).

Service to Universidad Autónoma del Estado de Morelos (UAEM)

- Member of Centro de Investigación en Biotecnología (CEIB/UAEM)-Graduated Students Admission Committee (1998-2002).

Community Service Judge of the 2006 Science Fair, Blessed Sacrament School, Jonesboro, AR, March 10, 2006. Judge of the 2007 Science Fair, Blessed Sacrament School, Jonesboro, AR, March 15, 2007. Judge, best undergraduate posters in Chemistry and Biochemistry, Fall 2008 INBRE –

Undergraduate Research Conference, University of Arkansas, November 7-8, 2008, Fayetteville, AR.

Judge of the 2009 Science Fair, Blessed Sacrament School, Jonesboro, AR, March 6, 2009. Synergistic activities Co-organized “1st International Workshop on Hairy Roots: Exploiting Plant Metabolism for

Agriculture and Medicine” in collaboration with Dr. Fabricio Medina-Bolivar, July 13 2006, Jonesboro, AR. My activities included planning of the content of the workshop, inviting international speakers, hosting speakers during their visit, fund raising (got $1,500 support from state wide Arkansas Biosciences Institute and $300 from Fisher Scientific), lead one of the hands-on exercises in the afternoon and planning all logistic aspects of the meeting (advertising, coffee breaks, meals, design of certificates for all attendees).

Main coordinator of signature of Memorandums of Agreement and Understanding between

Arkansas State University and Universities in México, Brazil, and Puerto Rico: - Division of Natural Sciences and Engineering, UAM-Cuajimalpa, México (liaison Dr.

Rodolfo Quintero), signed: April 2007. - Academic Body of Natural Products, UAEM, Cuernavaca, México (liaison Dr. María

Luisa Villarreal), signed: April 2007. - Universidad de Puerto Rico campus Mayagüez (liaison Dr. Rosa Buxeda). Process

started: December 2007. - Universidad Federal de Santa Catarina (liaison Dr. Claudia Simoes). Process started

June 2008.

Main coordinator and host of visits of well known speakers to ABI/ASU - Dr. Rachel Mata (October 16-18, 2006) - Dr. Rodolfo Quintero (November 1-4, 2006) - Dr. Rogelio Pereda-Miranda (November 30 - December 9, 2006) - Dr. Mario De Tullio (September 4-6, 2007) - Dr. Robert Reis (February 20, 2008) - Dr. Dimuth Siritunga (May 13-16, 2008) - Dr. Walter Suza (June 23-24, 2008) - Dr. Rogelio Pereda-Miranda (July 1st-12, 2008) - Dr. Alan Tackett (September 17, 2008) - Dr. Mariya Khodakovskaya (November 5th, 2008) - Dr. Fiona Goggin (December 2nd-4rd, 2008) - Dr. Paul Miller (February 18, 2009) Co-organizer of the “International Consortium of Collaboration in Plant-Powered Production”

This effort involves research institutes and universities from Argentina, Brazil, Peru, Mexico, and USA.

Provided molecular expertise to Hector Estrada, Jane Anfinson, and Troy Bader, students of Dr.

James Bednarz (Dept. of Biological Sciences, ASU), in the development of molecular speciation assays for their respective projects (Summer 2006 –Spring 2007).

Membership in professional societies International Phytochemical Society of North America (PSNA), 2002 to present. National American Association for the Advancement of Science (AAAS), 2001 to present. American Chemical Society (ACS), 2005 to present. American Society of Pharmacognosy (ASP), 2001 to present. American Society of Plant Biologist (ASPB), 2000 to present.

Society for the Advancement of Chicanos and Native Americans in Science (SACNAS), 2006 to present. Society for In Vitro Biology (SIVB), 2008 to present.

Regional Arkansas Academy of Science, 2006 to present. Arkansas Native Plant Society, 2006 to present. Faculty Women’s Club, Arkansas State University, October 2005 to present. Women in Science - ASU Chapter, September 2006 to present.

February, 2009.

FABRICIO MEDINA-BOLIVAR, Ph.D. Assistant Professor of Plant Metabolic Engineering

Arkansas Biosciences Institute and Department of Biological Sciences Arkansas State University, Jonesboro, AR

A. EDUCATION Cayetano Heredia Univ., Lima, Peru B.S. 1990 Biology Cayetano Heredia Univ., Lima, Peru Licenciate 1991 Biology Penn State University, State College, PA Ph.D. 1997 Plant Physiology Virginia Tech Postdoctorate 2001 Plant Biotechnology B. POSITIONS AND HONORS 2005-present Assistant Professor, Arkansas Biosciences Institute/ Dept. of Biological Sciences,

Arkansas State University, Jonesboro, AR 2005-present Co-Founder, Nature West Inc., Jonesboro, AR 2002-2005 Research Assistant Professor, Dept. of Plant Pathology, Virginia Tech,

Blacksburg, VA 2001-present Co-Founder/Vice President Plant Diagnostics, Nature Diagnostics Inc.,

Blacksburg, VA 1997-2001 Postdoctoral Research Scientist, Virginia Tech, Blacksburg, VA 1992-1997 Research Assistant, Pennsylvania State University, State College, PA Recent invited talks (in chronological order): The 2005 Phytochemical Society of North America Meeting, The Salk Institute, La Jolla, CA. August, 2005 (Invited Speaker) Arkansas Biosciences Institute Fall 2005 Research Symposium, Little Rock, AR. September, 2005 (Selected to represent Arkansas State University, Invited Speaker) National Center for Natural Products Research, Oxford, MS. October, 2005. (Invited Lecturer) Symposium on Medicinal Plants. American Society of Horticultural Sciences Annual Meeting, New Orleans, LA, July 25, 2006. (Invited Speaker) First International Workshop on Hairy Roots, Jonesboro, AR, July 13, 2006. (Invited Speaker) Phytochemical Society of North America Annual Meeting, Oxford, MS, July 8-12, 2006. (Invited Speaker) University of Arkansas for Medical Sciences. Little Rock, AR. November 16, 2006. (Invited Speaker) University of Arkansas, Little Rock, AR. January 29, 2007. (Invited Speaker). International Symposium on Medicinal and Nutraceutical Plants. Fort Valley, Georgia. March 2007. (Invited Speaker). 61st Tobacco Science Research Conference. Charlotte. NC. September 23-26, 2007. (Invited Speaker) VI Encuentro Latinoamericano y del Caribe de Biotecnologia Agroprecuaria. REDBIO/FAO. Vina del Mar, Chile. October 22-26, 2007. (Invited Speaker) Pablo Cassara Foundation. Buenos Aires, Argentina. October 30-31, 2007. (Invited Speaker). Southern Association for Agricultural Scientists, SAAS. February 2008. (Invited Speaker).

Society for In Vitro Biology, Tucson, AZ. June 2008. (Invited Speaker and Session Chair) – this talk was highlighted by Agricell Report on June 2008. International Drug Discovery Science and Technology Conference, Beijing, China. October 2008. (Invited Speaker). Chinese Academy of Sciences, Beijing, China. October 2008. (Invited Speaker) Honors: Co-Editor, Hairy Roots Special Issue, Electronic Journal of Intergrative Biosciences Recipient of the 2006 Arthur Neish investigator award from the Phytochemical Society of North America. Coordinator of an International Collaborative Research Agreement between Arkansas State University and the International Potato Center (Lima, Peru). Co-Organizer, First International Workshop on Hairy Roots, Jonesboro, AR, 2006. Primary coordinator of an International Collaborative Research Agreement between Arkansas State University and the National Council on Scientific and Technical Research (Argentina). Primary coordinator of an International Collaborative Research Agreement between Arkansas State University and the Universidad Nacional Agraria La Molina (Lima, Peru). Invited proposal application reviewer: North Carolina Biotechnology Center, American Institute of Science, US Army Medical Research and Materiel Command, Austrian Science Fund. Invited manuscript reviewer: Plant Physiology, Plant Cell Reports, In Vitro Plant Cellular and Developmental Biology, Planta Medica, Applied Biochemistry and Bioengineering, Planta Medica. Professional and Honor Memberships: American Consortium of Medicinal and Aromatic Plants (Elected membership) Phi Beta Delta - Honor Society of International Scholars (Elected membership) Sigma Xi – The Scientific Research Society (Elected membership) Gamma Sigma Delta - Honor Society of Agriculture (Elected membership) Cambridge Who’s Who (Elected membership) Who’s Who in Agriculture Higher Education (Elected membership) Professional Memberships: Phytochemical Society of North America, Society for In Vitro Biology, American Society of Plant Biologists, International Society for Horticultural Science C. STUDENTS AND ADVISEES: Current undergraduate students: Jordan Baker (Biology) Current graduate students: Jose Condori (Ph.D., Molecular Biosciences) Cesar Nopo-Olazabal (Ph.D., Molecular Biosciences) Maria Ferrand-Malatesta (Ph.D., Molecular Biosciences) Luis Nopo-Olazabal (Ph.D., Biochemistry and Molecular Biology/UPCH-Peru Shuchi Wu (M.S., Biology, ASU) Current visiting scholars: Hector Villagarcia (Peru)

Total post-doctoral researchers supervised: 3 Total graduate students supervised: primary 4; secondary 6 Total research assistants/associates supervised: 3 Total undergraduates supervised: 23 Total high school students supervised: 1 D. PUBLICATIONS Peer-reviewed publications (graduate students in the Graduate Program of Molecular Biosciences are shown in italics) 1. Porobo Dessai A, Gosukonda R, Blay E, Dumenyo C, Medina-Bolivar F, Prakash C. 1995.

Plant regeneration of sweet potato (Ipomoea batatas L.) from leaf explants in vitro using a two-stage protocol. Sci. Hort. 62: 217-224.

2. Medina-Bolivar F, Flores H. 1995. Studies on the manipulation of tropane alkaloid biosynthesis in hairy roots of Hyoscyamus muticus. In: Phytochemicals and Health. D.L. Gustine and H. Flores (eds). American Society of Plant Physiology, MD. pp 297-299.

3. Flores H, Medina-Bolivar F. 1995. Root culture and plant natural products: "Unearthing" the hidden half of plant metabolism. Plant Tiss. Cult. Biotechnol. 1: 59-74.

4. Medina-Bolivar F, Flores H. 1995. Selection for hyoscyamine and cinnamoyl putrescine overproduction in cell and root cultures of Hyoscyamus muticus. Plant Physiol. 108: 1553-1560.

5. Medina-Bolivar F, Flores H. 1998. Biosynthesis of constitutive versus inducible metabolites in hairy root cultures of Hyoscyamus muticus. In: Radical Biology: Advances and Perspectives on the Function of Plant Roots. H.E. Flores, J.P. Lynch, D. Eissenstat (eds), American Society of Plant Physiologists, Rockville, MD, pp. 430-431.

6. Medina-Bolivar F, Wright R, Sentz D, Barroso L, Wilkins T, Petri Jr. W, Cramer C. 2003. A non-toxic lectin for mucosal antigen delivery of plant-based vaccines. Vaccine 21:997-1005.

7. Lorence A, Medina-Bolivar F, Nessler C. 2004. Camptothecin and 10-hydroxycampthotecin from Camptotheca acuminata hairy roots. Plant Cell Rep. 22:437-441.

8. Medina-Bolivar F, Cramer C. 2004. Production of recombinant proteins in hairy roots cultured in plastic sleeve bioreactors. In: Recombinant Gene Expression: Reviews and Protocols. P. Balbas and A. Lorence, (eds.). Humana Press, Totowa, pp 351-363.

9. Reed D, Nopo-Olazabal L, Woffenden B, Funk V, Reidy M, Cramer C, Medina-Bolivar F. 2004. Expression of functional hexahistidine-tagged ricin B in tobacco. Plant Cell Rep. 24:15-24

10. Zhang C, Medina-Bolivar F, Buswell S, Cramer C. 2005. Purification and stabilization of ricin B from tobacco hairy root cultures by aqueous two phase extraction. J Biotech. 117:39-48

11. Buswell S., Medina-Bolivar F, Van Cott K, Zhang C. 2005. Expression of porcine prorelaxin in transgenic tobacco. Ann N Y Acad Sci. 1041:77-81.

12. Medina-Bolivar F. 2006. Rooting for new medicines. In: J. Trauth and A. Romero (eds.). Adventures in the Wild: Tales from Biologists of the Natural State. The University of Arkansas Press. pp. 83-88.

13. Medina-Bolivar F, Condori J, Rimando A, Hubstenberger J, Shelton K, Bennett S, Dolan M. 2007. Production and secretion of resveratrol in hairy root cultures of peanut. Phytochemistry. 68:1992-2003.

14. Medina-Bolivar F, Nopo-Olazabal C, Nopo-Olazabal L, Sivakumar G, Condori J. 2007. Screening for bioactives stilbenes in the genus Nicotiana. Recent Advances in Tobacco Science. 33:93-100.

15. Woffenden B, Nopo L, Cramer C, Dolan M, Medina-Bolivar F. 2008. Expression of a ricin B:F1:V fusion protein in tobacco hairy roots: steps toward a novel pneumonic plague vaccine. Electronic J Integrative Biosciences 3:10-19.

16. Pitta-Alvarez S, Medina-Bolivar F, Alvarez M, Scambatto A, Marconi P. 2008. In vitro shoot culture and antimicrobial activity of Berberis buxifolia Lam. In Vitro Cellular & Developmental Biology 44:502-507.

17. Sivakumar G, Christopher S, Medina-Bolivar F, Uccella N. 2008. Plant-based Small Molecules and Proteins: A Source for Natural Medicines. In: Plant Secondary Terpenoids. (in press).

18. Condori J, Medrano G, Sivakumar G, Nair V, Cramer C, Medina-Bolivar F. 2008. Functional characterization of a stilbene synthase gene using a transient expression in planta. Plant Cell Reports DOI 10.1007/s00299-008-0664-0.

Patent:

Medina-Bolivar F, Dolan M, Bennett S, Condori J, Hubstenberger J. 2007. Production of stilbenes in hairy roots. US Patent Application N. 11773178 International Patent Application N. PCT/US07/72756 A. Research Support Funded Grant Proposals Medina-Bolivar, F. (PI) “Metabolic engineering for the overproduction of medicinal phytochemicals” Arkansas Biosciences Institute $ 200,000 07/01/05-6/30/08 Medina-Bolivar, F. (PI), Grippo, A. “Effects of resveratrol-containing extracts from peanut hairy roots on human leukemia cells” Arkansas State University, Undergraduate Research Proposal $ 1,000 07/01/06-12/31/06 Medina-Bolivar, F. (PI) “Advanced training in HPTLC techniques for phytochemical analyses” Arkansas State University/Eleanor Lane Travel Award

$ 750 Sep 2006 Lorence, A., Medina-Bolivar, F. (Co-PI), Redeker, K. “Collaborative Seed Grant: Mechanisms of Toxicity and Remediation of Superfund Environmental Toxicants” Arkansas Biosciences Institute at Arkansas State University $ 34,500 07/01/06-06/30/08 Medina-Bolivar, F. (PI) “Development of Transgenic Sorghum Root Cultures for Production of Herbicides” Arkansas State University $ 7,000 07/01/06-06/30/07 Gilbert, K (AR Children’s Hospital Research Institute), Blossom S, Przyyla B, Pumford N, Fuscoe J, Medina-Bolivar F, Redeker K, Lorence A “Developing an immunotoxicology center in Arkansas” Arkansas Biosciences Institute at Arkansas Children’s Hospital Research Institute $ 200,000 (Note: funding provided to AR Children’s Hospital Res. Inst.) 07/01/07-06/30/08 Nirmal, J. (Fort Valley State Univ.), Prahlad, P. (Karmanos Cancer Inst. at Wayne State Univ.), Medina-Bolivar, F. (Co-PI, ASU), Shannon, D. (Auburn Univ.), Ellis, B. (USDA), Rimando (USDA) “Scutellaria as a medicinal crop: Cryopreservation, hairy root culture, organic farming and anticancer activity” United States Department of Agriculture (USDA), Cooperative State Research, Education and Extension Service (CSREES), 1890 Capacity Building Grant, National Competitive Proposal $ 434,258 10/01/08-09/30/11

Medina-Bolivar, F. (PI), Carrier, J. (Univ. of Arkansas, Fayetteville), Dolan, M. “Regulation, production and purification of bioactive stilbenoids from hairy root cultures of peanut” National Science Foundation, EPSCoR-P3 Center for Plant-Powered Production Competitive Proposal $ 248,250 05/16/08-11/15/09 Gilbert, K., Lorence, A., Medina-Bolivar, F. (Co-PI), Cramer, C., Phytoremediation of trichloroethylene Arkansas Children’s Hospital Research Institute $ 180,000 07/01/08-06/30/10

Khodakovskaya, M. (PI, UALR); Medina-Bolivar, F. (Co-PI, ASU). “Enhancing abiotic stress tolerance and production of antioxidant in plants for Advanced Life Support in Space Exploration”. Arkansas Space Grant Consortium $ 45,000 04/15/08-4/14/11 Khodakovskaya, M. (PI, UALR); Grace, S. (Co-PI, UALR); Ali, N. (Co-PI, UALR); Medina-Bolivar, F. (Co-PI, ASU). “Regulation of secondary metabolism in tomato by genetic manipulation of the phosphoinositol pathway”. NSF-EPSCoR P3 $ 149,928 Hannigan, R. (PI), Buchanan, R. (Co-PI), Cramer, C. (Mentor), Dolan, M. (Mentor); Bouldin, J. (Mentor), Christian, A. (Mentor), Lorence, A. (Mentor), Medina-Bolivar, F. (Mentor), Anh S. (Mentor), Green, S. (Mentor), Dowling, C. (Mentor), Phillips, G. (Mentor), Young, N. (Mentor) “Undergraduate Research and Mentoring in the Biological Sciences: Cross-disciplinary Research at the Intersection of Biotechnology and the Environment” National Science Foundation $ 1,112,685 01/15/08-12/15/13 Note: Dr. Medina-Bolivar was in charge of writing the Metabolite Identification section; Project 4, subproject 1 (“Development of chemical markers for black cohosh”) Cramer, C. (PI), Thompson, G., Korth, K Note: This proposal includes 21 scientists. Dr. F. Medina-Bolivar was involved in writing Objective II/Project 2 (“Manipulating of the terpenoid pathway for discovery and bioproduction of valuable phytochemicals in hairy roots”) and Objective III/Objective 2/Aim 2 (“Elicitation as a gene discovery tool for master regulators of terpenoid biosynthesis in hairy roots”). “Arkansas ASSET Initiative” – Plant Bioproduction Project National Science Foundation EPSCoR Research Infrastructure Improvement Program $ 9,000,000 05/01/07-04/30/10 Grant Proposals Submitted (Funding pending as of Feb 2009) Cramer, C. (PI, ASU), Chappell, J. (Co-PI, Univ. of KY), Medina-Bolivar, F. (Co-PI, ASU); Lorence, A. (Co-PI, ASU), Weathers, P. (Co-PI, Wocester Polytech. Inst.); Xu, J. (Co-PI, ASU). Note: Collaboration with Mexico and Peru. “Phyochemical adaptations: Discovering how environments and genetics interact to promote biochemical diversifications” National Science Foundation – Partnership for International Research and Education (PIRE) $ 4.1 Million (preproposal submitted 2/26/09)

Medina-Bolivar, F. (PI, ASU); Srivatsan (Co-PI, ASU). “Neuroprotective activity of natural stilbenoids”. National Institute of Health – R21 Exploratory National Competitive Grant Proposal Priority score: 238 $ 339,322 (Submitted 7/16/08) Khodakovskaya, M. (PI, UALR); Ali, N. (Co-PI, UALR); Medina-Bolivar, F. (Co-PI, ASU). “Enhancing abiotic stress tolerance, biomass production and accumulation of antioxidants in plants for Advanced Life Support in Space Exploration”. NASA-EPSCoR $ 673,360 (Submitted 12/3/08) Funded Grant Proposals From Previous Appointment (at Virginia Tech) Cramer, C. (BioDefense Technologies, PI), Medina-Bolivar, F. (Virginia Tech, PI), Dolan, M. “Nasally-delivered mucosal vaccine for plague” Sub-Contract from NIH/Small Business Technology Transfer (STTR) national competitive grant (STTR, R41 AI 52958-01) to BioDefense Technologies, Inc. Funding: $108,121 (sub-contract) $ 108,121 (to Medina-Bolivar) 1/1/03-12/31/03 Petri Jr., W. (Univ. of Virginia), Buck, G. (VA Commonwealth Univ.), Nessler, C. (VA Tech) “The Virginia Consortium for Mucosal Therapy of Infectious and Autoimmune Diseases” State of Virginia, Commonwealth Technology Research Fund $ 3.6 Million ($ 1.2 Million to Medina-Bolivar) 1/1/02-5/30/05 Note: Dr. Medina-Bolivar participated in writing part of this proposal. He was appointed as Research Director for the Virginia Tech component of this project.

BRIEF BIO-DATA FOR DR. GREGORY C. PHILLIPS Dr. Gregory C. Phillips was named the ASU Dean of the Colleges of Agriculture & Technology; Engineering; and Sciences and Mathematics in July 2005. Dr. Phillips has served as the Dean of the College of Agriculture at Arkansas State University since July 2003. Since his arrival in 2003, he has modified the College of Agriculture & Technology undergraduate core curriculum, implemented inquiry-based seminars, strengthened the research component of the graduate curriculum, added a food technology program, renovated the campus farm, and added petting zoo and farmers’ market service programming. He has forged interdisciplinary research programs at the interface of agriculture and the environment, expanded cooperative research efforts with the University of Arkansas Division of Agriculture, and provided co-leadership for research and a new doctoral program (Molecular Biosciences) at the interface of agriculture and medicine. He has reoriented the Technology Program to be more supportive of regional economic development. He has overseen a successful accreditation visit by ABET to the College of Engineering, and the development and implementation of new discipline-specific engineering degrees. He has overseen the expansion of extramural grants and contracts by four-fold in the Colleges of Sciences & Mathematics and Agriculture & Technology. As dean over the three colleges, Dr. Phillips provides leadership to recruit excellent faculty and staff, promoting interdisciplinary curricula and research structures across campus, inquiry-based and experiential learning in curricula, and entrepreneurial training embedded in the sciences and technology disciplines. He manages the three colleges as independent units with unique missions, cultures and needs; and he urges collaboration across units as a mechanism for self-improvement and to achieve synergies where possible.

Previously, he was a professor in the Department of Agronomy and Horticulture at New Mexico State University, where he was located for 22 years. During 2001-2003, he served as a co-chair of the NMSU Nanotechnology Steering Committee, aimed at coordinating campus wide research efforts across relevant disciplines. From 1992-1999, he served as the Director of the NMSU Molecular Biology Program, an interdisciplinary academic and research training program encompassing faculty and students from several departments in three colleges. From 1996-1998 he was the Science Coordinator for the National Biotechnology Information Facility at NMSU involving bioinformatics research and outreach, and participated in campus wide efforts related to information science during 2002-2003. Previously he served as the interim director (1983-1985) and then associate director (1986-1990) for the Plant Genetic Engineering Laboratory at NMSU, a research institute with an economic development mission. Dr. Phillips received a B.A. degree in Philosophy (1975) and a Ph.D. degree in Crop Science (1981) with a major in plant breeding and genetics and a minor in plant physiology, both degrees awarded from the University of Kentucky. Dr. Phillips' research has focused on the development and application of cell genetics and biotechnology to improve crop plants. His extramural research support (over $6,000,000) has been awarded by various competitive grants panels and private companies. He has authored or co-authored 40 refereed journal articles, 30 invited chapters, co-edited a lab manual on plant tissue culture methods, and has over 85 other miscellaneous publications and abstracts. He has been an ad-hoc reviewer for 15 different journals and for 23 panels or divisions of 8 different federal funding agencies. He has served as an officer for the Plant Division of the Society for In Vitro Biology, and for the NMSU chapter of the honor society Gamma Sigma Delta. Dr. Phillips has been active for over 20 years as an editor for the journal Plant Cell Reports, and 1999-2007 he assumed the role of editor-in-chief for the society-based journal In Vitro Cellular and Developmental Biology – Plant after serving as an associate editor for 10 years. In 2004 Dr. Phillips was inducted as a Fellow of the Society for In Vitro Biology.

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SUMMARY OF ADMINISTRATIVE EXPERIENCE Gregory C. Phillips

Formal Administrative Appointments:

Department of Horticulture, New Mexico State University (NMSU), Acting Co-Head, 1982-1983 during search for new department head ● Primary responsibility for analysis and management of departmental budgets ● Primary responsibility for renovation of departmental facilities and acquisition of equipment ● Assisted the other acting co-head in administrative meetings, meeting administrative deadlines, personnel matters, etc. as needed

Plant Genetic Engineering Laboratory, NMSU, Interim Director, 1983-1985, during launch of the Rio Grande Research Corridor state economic development initiative as one of five Centers of Excellence ● PI for $1.5M budget ● Developed a strategic plan for budgeting, initiating interdisciplinary research program, development of facilities, acquisition of equipment, and recruitment of world-class Director/Lead Scientist ● Coordinated and managed inaugural rounds of interdisciplinary research programs ● Coordinated hiring of junior faculty and personnel ● Led the search for the permanent Director/Lead Scientist ● Represented PGEL at university and state legislative meetings, coordinated with Los Alamos National Labs, developed industry partners, etc.

Plant Genetic Engineering Laboratory, NMSU, Associate Director, 1986-1990

● Co-PI for $3.5M budget ● Assisted in hiring of faculty and personnel ● Assisted in developing a mechanism for evaluation of PGEL faculty jointly appointed with academic departments ● Assisted in implementing and coordinating interdisciplinary research and development programs ● Assisted in developing R&D spin-off business plans

Molecular Biology Graduate Program, NMSU, member of Steering Committee, 1987-1988

● Assisted in developing proposals for new interdisciplinary M.S. and Ph.D. degree programs, the first such cross-unit graduate programs on campus ● Assisted in developing model for administrative oversight and faculty evaluations for the interdisciplinary graduate programs ● Assisted in successful adoption of these proposals through the university and state systems

Molecular Biology Program, NMSU, Director, 1992-1999

● Managed $120,000 annual operating budget ● Supervised two office personnel and six Graduate Teaching Assistants ● Coordinated participation of 26 faculty from three colleges ● Contributed annual performance assessments for participating faculty, coordinating with six department heads and four college deans ● Increased the number of M.S. and Ph.D. majors by 50% through implementation of recruitment and funding strategies ● Involved the graduate students in representative governance of the program

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● Implemented a formal undergraduate minor as a feeder/preparatory program ● Coordinated the revision of the requirements for the Qualifying/Core Exam, the Comprehensive Exam, and the graduate seminars such that the students had better defined expectations for each step and the faculty had better information for decision- point making related to retention and academic progress ● Launched a regional symposium series, the Zia Symposia in Molecular and Cellular Biology, drawing graduate and undergraduate students and faculty and scientists from numerous institutions ● Developed and managed a 7,200 sf Core Research and Training Facility for interdisciplinary projects ● Coordinated the acquisition of multi-user instrumentation and assisted in multi-user access policies ● Initiated the Bioinformatics/Computational Biology Graduate Minor ● Served as an informal ombudsman for students and staff, etc.

National Biotechnology Information Facility, NMSU, Biotechnology Science Coordinator,

1996-1998 ● Co-PI for $8.5M budget ● Developed strategic plan for implementing web-based depository of biotechnology information ● Coordinated the design and oversight of content material ● Coordinated the design and oversight of novel databases ● Assisted in NBIF outreach programs

Editor-in-Chief, In Vitro Cellular & Developmental Biology - Plant journal, Society for In Vitro

Biology, 1999-2007 ● Oversaw the scientific content and policies related to publication of the scientific journal ● Instituted the first Editorial Board ● Improved and formalized the editorial procedures and policies ● Redefined the editorial scope and peer review criteria used by the journal ● Involved with two rounds of RFPs for new contract publishing services and advising the Society’s Board on publication issues and finances ● Coordinated the implementation of an online version of the journal to complement the existing print version ● Expanded the scope of the journal from a national to an international base ● Improved the journal impact factor rating by 100% ● Developed a cooperative publication mechanism within the journal via special issues for the International Society for Plant Biotechnology under its independent Editorial Board and Editor ● Developed a Professional Code of Conduct and Editorial Guidelines for Plant Tissue Culture and Biotechnology Journals in conjunction with editors from four related society and private journals ● Transitioned the journal to a web-based automated submission and editorial tracking system ● Established and oversaw an Editorial Office including copyediting support ● Marshalled the journal’s finances to become a self-sustaining profit-center for the Society, in the black for the past three consecutive years and well into the future, for the first time in the journal’s history ● Developed a job description for the successor Editor-in-Chief and participated on the screening

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committee

Editor-in-Chief Emeritus, In Vitro Cellular & Developmental Biology - Plant journal, Society for In Vitro Biology, 2008-present ● Redefined the editorial scope and peer review criteria used by the journal to integrate the policies of the two cooperating societies into a single seamless and consistent editorial process ● Implementing a streamlined workflow process to integrate the two societies into every issue of the journal ● Integrating the list of Reviewing Editors across both societies while maintaining independent Editorial Boards for each society

Dean of the College of Agriculture and Director of Agricultural Research, Arkansas State

University, 2003 – present ● Oversee 16 faculty and 15 staff in five academic program areas offering B.S. and M.S. degrees ● Coordinate research and extension activities with University of Arkansas Division of Agriculture ● Oversee ASU Farm Complex, ASU Equine Center, and Delta Center for Agricultural Water Use ● Oversee annual academic and research budgets in excess of $2 million including salaries and operations ● Oversee the cross-college Doctoral Program in Molecular Biosciences ● Renamed College of Agriculture & Technology in 2008, adding 3 faculty in Technology ● Participated in private fundraising in excess of $1.3 million to date (deans at ASU were not encouraged to participate in private fundraising until 2007) ● Renovated the ASU Farm and generated a positive revenue flow for the past three years, reversing a decades-long trend in the red regarding revenue expectations ● Developed an Animal Science classroom, teaching lab and surgery room to complement the existing Plant Sciences classroom and teaching lab at the ASU Farm ● Renovated research facilities and expanded research infrastructure at the ASU Farm ● Initiative to establish renewable energy sources at the ASU Farm ● Doubled the number of ASU faculty involved in University of Arkansas Division of Agriculture sponsored research ● Coordinated a major research emphasis on agricultural water use and quality in conjunction with the Environmental Sciences Program ● Coordinated a major research emphasis on biofuels and bio-based products in coordination with the Arkansas Biosciences Institute ● Oversaw the quadrupling of extramural funded grants and contracts ● Assisted in the recruitment of Nice-Pak, Inc. to Jonesboro ● Restructured the college capstone into a seminar emphasizing information literacy, interpretation of technical articles, and professional presentations both written and verbal ● Restructured the college core curriculum to include emphases on experiential learning, entrepreneurship, and service learning as well as science and agribusiness ● Initiated new academic programs in food science/technology and metallurgical technology, and new courses in biotechnology and spatial technology ● Hosted international Fulbright Scholars, student exchanges with Brazil, study tours of Costa Rica, sponsored ASU faculty for international programs and Fulbright Scholars ● Co-developed the campus’ first Bachelor of Applied Science degree to articulate with

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Associate of Applied Science degrees in a true 2+2 manner ● Initiated new scholarships in Entrepreneurship, Leadership, and Career Development Event Performance ● Initiated a college Student Ambassadors program ● Initiated a Summer Youth Horse Camp at the ASU Equine Center ● Re-established the ASU Rodeo Team at the ASU Equine Center ● Initiated the ASU Petting Zoo, held once per semester, for both public school field trips and the general public, as a service learning/public outreach program, hosting nearly 4,000 visitors at each event ● Co-sponsored the ASU Regional Farmers’ Market by hosting at the ASU Farm and providing faculty and staff support, hosting about 1,000-1,200 visitors each week ● Co-sponsored the North Delta Ag Expo at the county fairgrounds, hosting about 1,000 visitors annually ● Established a college newsletter, written by students with faculty supervision, for alumni and friends of the college, with two issues annually ● Strengthened the support for student club activities, service learning, experiential learning and public outreach through fundraising events

Dean of the Colleges of Agriculture & Technology; Engineering; and Sciences & Mathematics,

Arkansas State University, 2005 – 2009; in anticipation of a major institutional Capital Campaign in 2009 and the recognized need to free up additional time for deans to be involved in fundraising activities, the College of Sciences & Mathematics will transition to an Interim Dean effective January 1, 2009, and the College of Engineering will transition to a new permanent Dean as soon as the incumbent is identified later in 2009 ● Oversee 92 faculty and 24 staff in 16 academic program areas offering a variety of bachelor’s, master’s and doctoral degrees ● Oversee annual academic budgets in excess of $8.5 million in salaries and operations, and research budgets in excess of $12 million ● Oversee Ecotoxicology Research Facility, and Arkansas Center for Laser Applications and Science, both in Sciences & Mathematics, in addition to the ASU Farm Complex and Delta Center for Agricultural Water Use ● College of Engineering Highlights: • Oversaw a successful accreditation visit by ABET for the Bachelor of Science in Engineering degree • Oversaw the development of successful proposals for and implementation of discipline-specific undergraduate degrees in Electrical Engineering, Civil Engineering, and Mechanical Engineering • Oversaw the development of successful proposals for and implementation of a Master’s in Engineering Management degree • Established a college Student Ambassadors program • Hosted an Earthquake Awareness and Preparedness Conference with 150 attendees from regional government agencies and universities • Assisted in strengthening experiential and service learning in the capstone Senior Design course by expanding from one to two semesters and incorporating design projects suggested by regional companies • Assisted in recruiting Nordex Industries wind turbine plant to Jonesboro ● College of Sciences & Mathematics Highlights: • Oversaw the quadrupling of extramural grants and contracts, with major emphases on

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Science Education, chemical residue detection (weapons, explosives, drug applications), and laser science • Received national recognition from COPUS (Coalition on the Public Understanding of Science) for series of articles and reports highlighting ASU research and outreach activities appearing weekly in 30 regional newspapers, and periodically in radio and TV spots • Developed the science building lobby areas into the Hall of Science, with exhibits from various departments, as well as a series of posters illustrating how research and discovery are integrated with professional development and academics, highlighting research results from college students • Became a regional hub for the BEST (Boosting Engineering, Science and Technology) Robotics Competitions • Initiated outreach with local elementary Magnet Schools in Environmental Science, Science and Math • Initiated plan for and reallocated resources to support request for accreditation in Computer Science • Provided support and leadership for major international exchange initiative with institutions in China and Taiwan

Administrative Support Roles as a Faculty Member:

Faculty Senate, member (two terms) University Research Council, member Molecular Biology Curriculum Committee, Chair Plant Genetics Option in the Undergraduate Majors of Horticulture and Agronomy, Chair Agronomy & Horticulture Graduate Studies Committee, Chair Gamma Sigma Delta, NMSU Chapter, Vice President, 1994-1995; President, 1995-1996 Society for In Vitro Biology – Plant Division, Secretary/Treasurer, 1996-1998 Institutional Academic Program Review of the Department of Philosophy, Chair University Interdisciplinary Programs Committee, Chair Fluorescence Imaging Facility (nee: Confocal/Multi-Photon Microscopy Resource) Users Committee,

Chair Electron Microscopy Laboratory Users Committee, Chair Skeen Hall Research Equipment Committee, co-Chair Skeen Hall Teaching Equipment Committee, co-Chair University Equipment Committee, member (provided leadership for development of Multi-User Facilities

Policies for campus) Nanotechnology Steering Committee, co-Chair Joint University Research Council-Equipment Committee Ad-hoc Committee on Institutional Indirect

Costs Recovery and Use, member Information Science Strategic Planning Committee, member Research/Academic Collaborative Centers Policies Ad-hoc Committee, member

Administrative Philosophy:

Participatory Input and Management Facilitation – Help Others to Navigate the System and Realize their Creative Potential Problem Solving and Brainstorming People Are Our Most Valuable Resource and Most Critical Investment Promote Professional Development and Ethical Conduct Plan Implement Review Improve Repeat Cycles

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Brief Mission Statement:

Prepare capable students for the workplace and for a life worth living Generate new knowledge and technology Solve problems and do the right thing Support economic development and desirable industry

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CURRICULUM VITAE I. Gregory Conrad Phillips Professor of Plant Biotechnology Dean of the Colleges of Agriculture & Technology; Engineering; Sciences & Mathematics

Director of Agricultural Research

Arkansas State University P.O. Box 1080 Home Address: 119 S. Caraway Road 2111 Spring Hollow Drive State University, AR 72467-1080 Jonesboro, AR 72404

Telephone: (870) 972-2085 (870) 932-4451 (mobile 870-897-2265) FAX: (870) 972-3885 E-mail: [email protected] II. Date and Place of Birth: 11 September 1954 Covington, KY United States Citizen III. Marital Status: Married to Louise Dedman Phillips, CPA Children: Isaac Clarke, b. 07-06-81 Daniel Conrad, b. 10-30-84, d. 10-30-84 Jessalyn Kai, b. 10-23-86 IV. Hobbies: Guitar, musical composition and performance Fishing Billiards V. Education University of Kentucky, 1971-1975, Bachelor of Arts Major: Philosophy Emphasis: Epistemology Member: Honors Program GPA: 3.62 (4 point scale)

Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, April-July 1978, Graduate Research Training

Topic: Plant Protoplasts and Cell Cultures Advisors: O.L. Gamborg and D.A. Evans University of Kentucky, 1976-1981, Doctor of Philosophy Program: Crop Science Major: Plant Genetics and Breeding Minor: Plant Physiology GPA: 3.62 (4 point scale)

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Advisors: G.B. Collins and N.L. Taylor Dissertation Title: Hybridization of red clover with a perennial Trifolium species using in vitro embryo rescue

Objectives: 1. Develop cultural routine for rescue of immature embryos of the wide cross, prior to seed abortion, using a defined media sequence

2. Provide genetic, cytological and biochemical evidences for the hybrid nature of rescued plants

VI. Employment Record and Background

Family, farm work, part-time summers through 1970, Grant County, Kentucky

University of Kentucky, Department of Agronomy, part-time 1971-1975, tobacco field and laboratory research, Lexington, Kentucky

University of Kentucky, Department of Agronomy, 1976-1981, Research Assistant in Plant Cell Genetics, Lexington, Kentucky

New Mexico State University, Department of Horticulture, 1981-1985, Assistant Professor of Plant Tissue Culture and Cell Genetics, Las Cruces, New Mexico

New Mexico State University, Plant Genetic Engineering Laboratory, 1983-1985, Interim Director, Las Cruces, New Mexico (PI on $1,500,000 contract)

New Mexico State University, Department of Agronomy and Horticulture, 1985-1990, Associate Professor of Plant Cellular and Developmental Biology, Las Cruces, New Mexico

New Mexico State University, Plant Genetic Engineering Laboratory, 1986-1990, Associate Director, Las Cruces, New Mexico (Co-PI on $3,500,000 contract)

EuCl∩nIt™, consultants in plant biotechnology research and development, 1987-2003, co-founder and principal consultant, Las Cruces, New Mexico

University of Kentucky, Department of Agronomy, 1989-1990, Research Sabbatical in Plant Molecular and Cellular Genetics, Lexington, Kentucky

New Mexico State University, Department of Agronomy and Horticulture, 1990-2003, Professor of Plant Cellular and Molecular Genetics, Las Cruces, New Mexico

New Mexico State University, Molecular Biology Program, 1992-1999, Director, Las Cruces, New Mexico (responsible for $120,000 annual budget, 7,200 s.f. core facility, 22 Ph.D. majors, 12 M.S. majors, 24 undergraduate minors, interdisciplinary program involving 26 faculty in six departments from three colleges)

New Mexico State University, National Biotechnology Information Facility, 1996-1998, Science Coordinator, Las Cruces, New Mexico (Co-PI on $8,455,000 grant) Arkansas State University, Dean and Director of Agricultural Research, College of Agriculture,

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2003-present, Professor of Plant Biotechnology, Jonesboro, Arkansas Arkansas State University, Dean of the Colleges of Agriculture & Technology, Engineering, and Sciences & Mathematics, 2005-2008, Jonesboro, Arkansas. (Currently searches are underway for dedicated deans for Engineering and Sciences & Mathematics in preparation for a major Capital Campaign at ASU) Arkansas Agriculture Board, ex-officio member, 2005-present

VII. Institutional and Public Professional Activity Community Jonesboro Regional Chamber of Commerce Jonesboro University Rotary Club, board member 2007-present, secretary 2008-2009, vice president 2009-2010 North Delta Ag Expo (non-profit), ex-officio board member 2007-present University Graduate Faculty

Center of Technical Excellence - Plant Genetic Engineering, Chair of Planning Committee; Interim Director; Associate Director

Search Committee, Plant Genetic Engineering Laboratory Lead Scientist/Director Molecular Biology Graduate Program, Steering Committee Molecular Biology Curriculum Committee, Chair Molecular Biology Program, Director Faculty Senate University Research Council Westhafer Award Committee Chemistry Building Addition Construction Committee Institutional Academic Program Review of the Department of Philosophy, Chair Interdisciplinary Programs Committee, Chair Fluorescence Imaging Facility/Confocal Microscopy Resource Users Committee, Chair University Safety Committee Electron Microscopy Laboratory Users Committee, Chair University Equipment Committee Nanotechnology Steering Committee Joint URC-Equipment Ad-hoc Committee on Institutional Indirect Costs Recovery and Use Information Science Strategic Planning/Umbrella Committee Research/Academic Collaborative Centers Policies Ad-hoc Committee, member Doctoral Program in Molecular Biosciences, ASU Co-coordinator University Calendar Committee University Planning Committee (budget) Faculty Handbook Committee (shared governance) Academic Deans Council, member, chair 2008-2009

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College Horizons and All-College Conferences Panels AES State and Regional Project Reviews Search Committee, AES Director CSDAL Building Tissue Culture Teaching Equipment Subcommittee, Chair CSDAL Building Research Equipment Committee, Co-Chair CSDAL Building Teaching Equipment Committee, Co-Chair Curriculum Committee Department Acting Co-Head, Horticulture, 1982-1983 Budget Analysis and Accountability, Chair Major Equipment and Growth Chambers, Chair Facilities and Space Utilization Laboratory Safety Curriculum, including development of Plant Genetics Options; Chair Promotion and Tenure Graduate Studies, Chair Safety Liaison Faculty and Staff Awards Professional Societies American Society of Agronomy (not current) Crop Science Society of America (not current) American Society for Horticultural Science (not current) International Association for Plant Tissue Culture & Biotechnology Society for In Vitro Biology; Secretary/Treasurer, Plant Division, 1996-1998 Gamma Sigma Delta; New Mexico Chapter Vice President, 1994-1995; New Mexico Chapter President, 1995-1996 Professional Service Editor, Plant Cell Reports journal, 1985-present Associate Editor, In Vitro Cellular and Developmental Biology - Plant journal, 1989-1998 Editor-in-Chief, In Vitro Cellular and Developmental Biology - Plant journal, 1999-2007 Editorial Board, Kertiszeti Tudomany (Hungarian Journal of Horticultural Science), 1994-1997

Editorial Board (ex officio), Journal of the International Association of Plant Tissue Culture and Biotechnology, 1998-2010

Plant Cell, Tissue and Organ Culture journal reviewer Crop Science journal reviewer Journal of the American Society for Horticultural Science reviewer HortScience journal reviewer Plant Physiology journal reviewer Journal of Plant Physiology reviewer Theoretical and Applied Genetics journal reviewer

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Plant Science journal reviewer Physiologia Plantatrum journal reviewer Annals of Botany journal reviewer Canadian Journal of Forest Research reviewer Environmental and Experimental Botany journal reviewer Plant Growth Regulator Society of America Quarterly journal reviewer Peanut Science journal reviewer Plant Foods for Human Nutrition journal reviewer Journal of Arid Environments journal reviewer North American Alfalfa Improvement Association, Tissue Culture Committee Crop Science Society of America, Crop Biotechnology Terminology Committee Society for In Vitro Biology, Plant Division, Ad-hoc Committee on Terminology, Chair Society for In Vitro Biology, Publications Committee American Peanut Research and Education Society, Panel on Tissue Culture, Chair International Congress of Plant Tissue and Cell Culture 1986, Paper Session Chair USDA-CRGO Plant Genetic Mechanisms and Molecular Biology Review Panel 1989 USDA-CRGO/NRI Genetic Mechanisms for Crop Improvement and Plant Molecular Biology;

Plant Genome; Biotechnology; North Central Biotechnology Consortium; Growth and Development of Plants; Biologically Based Pest Management; Biological Stress on Plants; Entomology/Nematology; Assessing Pest Control Strategies; Forest Biology; Caribbean Basin Advisory Group; SBIR; ARS Cooperative Research Agreements; Ad-hoc reviewer

NSF Cellular Biosciences; Integrative Plant Biology; Bioengineering and Environmental Systems; International Programs Cooperative Science; Research Opportunities for

Women; Instrumentation; SBIR; Ad-hoc reviewer NIH Biological and Chemical Studies of Taxol, Ad-hoc reviewer

NRC Science and Technology for International Development, Ad-hoc reviewer DOE Basic Life Sciences, Ad-hoc reviewer International Arid Lands Consortium, Ad-hoc reviewer Universities Council on Water Resources, Ad-hoc reviewer North Carolina Biotechnology Center, Ad-hoc reviewer

Consortium for Plant Biotechnology Research, Ad-hoc reviewer Tobacco Health and Research Institute, Ad-hoc reviewer Harper Collins Publishers; Addison-Wesley-Longman Publishers; John Wiley & Sons

Publishers; Ad-hoc reviewer Symposia Organized Applications of Cellular and Molecular Genetic Engineering in Agriculture, New Mexico State University, April 1982, Chair of Organizing Committee First Rio Grande Research Corridor Plant Biotechnology Conference, Los Alamos National Laboratory, October 1984, Organizing Committee

First Zia Symposium on Molecular and Cellular Biology at New Mexico State University: Plant Cell Biology, January 1995, Organizing Committee

Second Zia Symposium on Molecular and Cellular Biology at New Mexico State University:

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Emerging and Diverging Microbes, January 1997, Organizing Committee Selected Invited Seminars and Consulting Tissue and cell culture applications in crop improvement as illustrated with red clover (Trifolium pratense L.). USDA, Beltsville, MD, September 1978

In vitro tissue culture and plant regeneration in Trifolium pratense L. NSF-CNRS Seminar on Plant Regeneration, Orsay, France, June 1980

The development and use of in vitro breeding approaches for the improvement of red clover (Trifolium pratense L.). Molecular Genetics, Inc., Minnetonka, MN, September 1981

The role of plant tissue culture methods in genetic engineering. Oklahoma State University Biotechnology in Agriculture Symposium, Stillwater, OK, March 1982

Studies on somatic embryogenesis in clover, soybean and onion. Monsanto Agricultural Products, St. Louis, MO, August 1982

A modeled approach to legume plant regeneration in vitro. SunGene Technologies Corp., Palo Alto, CA, July 1983

A strategy to bridge molecular and cellular approaches to crop improvement. S-179 Regional Project Meeting, Atlanta, GA, October 1983

Tissue and cell culture approaches aimed at onion improvement. Thirty-fifth Annual Meeting of the Tissue Culture Association, Houston, TX, June 1984

Applications of cellular and molecular genetics to crop improvement. United AgriSeeds, Inc., Champaign, IL, October 1984

Totipotency is expressed by manipulation of discrete developmental stages in clovers, onions and Pinus. Louisiana State University Biotechnology Seminar Series, Baton Rouge, LA, March 1986

Developmental models for the expression of totipotency and plant regeneration in vitro. Eighty-fifth Annual Meeting of the Southern Association of Agricultural Scientists, Biochemistry and Biotechnology Section, New Orleans, LA, January 1988

Opportunities for cellular and molecular biology research in Pinus eldarica to develop genetic resistance to insect pests. Thirty-ninth Annual Western Forest Insect Work Conference, Flagstaff, AZ, March 1988

Key biosynthetic enzymes involved in plant abiotic stress tolerances: ammonia detoxication and polyamine syntheses. Southwest Consortium on Plant Genetics and Water Resources, Third Annual Symposium, Las Cruces, NM, April 1988

Biosynthesis of uncommon polyamines: potential role in plant tolerances to drought and heat.

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Sixty-fifth Annual Meeting Southwestern and Rocky Mountain Division, AAAS, Las Cruces, NM, April 1989

Micropropagation of threatened and endangered species of the Cactaceae. Fortieth Annual Meeting Tissue Culture Association, Orlando, FL, June 1989

Biosynthesis of uncommon polyamines in higher plants and their relation to abiotic stress responses. Annual Penn State Univ. Symposium in Plant Physiology: Polyamines and Ethylene, University Park, PA, May 1990

Uncommon polyamine biosynthesis is induced in association with plant abiotic stress tolerances. CIBA-GEIGY Corporation, Research Triangle Park, NC, February 1991

Drought and heat stresses influence polyamine metabolism in plants. University of New Mexico, Albuquerque, NM, April 1991

Micropropagation of rare and endangered cacti. International Symposium: Applications and Prospects of Biotechnology for Arid and Semiarid Lands, Lubbock, TX, November 1992

Applications of biotechnology for propagation and conservation of rare and endangered cacti. Symposium on Horticulture and Plant Biotechnology, Universidad Autonoma de Chihuahua, Chihuahua, Mexico, October 1993

Biochemical and genetic regulation of uncommon polyamines in higher plants and their relation to abiotic stress responses. Pioneer Hi-Bred International, Johnston, IA, October 1993

Uncommon polyamines may be involved in adaptation of crop plants to extreme environments. Institute of Biotechnology and Department of Plant & Soil Sciences, Texas Tech University, Lubbock, TX, October 1994

Agrobacterium-mediated transformation of forage and grain legumes to improve protein quality. Second International Plant Tissue Culture Conference, Dhaka University, Dhaka, Bangladesh, December 1995

Publishing in the SIVB journal In Vitro Cellular and Developmental Biology - Plant. 1996 World Congress on In Vitro Biology, Society for In Vitro Biology, San Francisco, CA, June 1996

Single-point access to biotechnology information and analysis tools via the world wide web. 1997 Congress on In Vitro Biology, Society for In Vitro Biology, Washington, DC, June 1997.

Web-based single-point access to biotechnology information and analysis tools. Annual Meeting of the American Society for Horticultural Science, Salt Lake City, UT, July 1997. Guidelines for publishing original research in plant tissue culture and biotechnology journals. BioVeg 2003, Cuba (via distance delivery), June 2003 Panel: The role of regional industries, institutions, and universities in economic development.

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Mississippi Delta Regional Issues Fall Conference, Little Rock, AR, October 2003 VIII. Recognitions

Pen and Scroll Award, Tates Creek High School, Lexington, KY, 1972

Undergraduate Honors Program, University of Kentucky, Graduated with High Distinction, 1972-1975; Editor, Honors Program Newsletter and Assistant Editor, The Jar (Honors Program Creative Writing Magazine), 1974-1975

Oswald Undergraduate Research and Creativity Award, First Place, Biological Sciences, University of Kentucky, In vitro ovule culture of N. tabacum by anther culture technique, 1974

Graduate Research Assistantship, Department of Agronomy, University of Kentucky, 1976-1981

Induction to Gamma Sigma Delta, Honor Society of Agriculture, 1984

Distinguished Service Award, College of Agriculture and Home Economics, New Mexico State University, 1991

Vice President 1994-1995, President 1995-1996, NMSU Chapter of Gamma Sigma Delta Secretary/Treasurer 1996-1998, Plant Division, Society for In Vitro Biology

Fabian Garcia Founders’ Award of Excellence, College of Agriculture and Home Economics, New Mexico State University, 2001 Recognition of Outstanding Coordination and Presentation of the Departmental Seminar Series, Department of Agronomy & Horticulture, New Mexico State University, 2002 Fellow Award, Society for In Vitro Biology, 2004 Rotarian Newcomer of the Year, Jonesboro University Rotary Club, 2007 Board Member, Jonesboro University Rotary Club, 2007 – present; Secretary, 2008 – 2009; Vice President 2009 – 2010

IX. Teaching Experience

Courses

Agronomy 697, Tissue and Cell Culture Methods in Plant Improvement, 3 credits, lecture and laboratory, new course, University of Kentucky, Fall 1979

Horticulture/Agronomy/Biology 340, Plant Tissue Culture Methods, 3 credits, lecture and laboratory, ew course, New Mexico State University, Fall 1983, Fall 1985, Fall 1991, Spring 1994, Spring 1996, Fall 1998, Spring 2001, Spring 2003

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Horticulture 520/598, Plant Cell Genetics, 3 credits, new course, New Mexico State University, Fall 1983, Fall 1985

Horticulture/Crop and Soil Sciences 485, Genetic Engineering of Plants, 3 credits, new course, New Mexico State University, Spring 1984, Spring 1986

Horticulture/Biology/Crop and Soil Sciences 531, Plant Physiology: Growth and Development, 3 credits, revised course, New Mexico State University, Fall 1984

Horticulture/Agronomy 685, Plant Genetic Engineering, 3 credits, revised course, New Mexico State University, Spring 1988

Horticulture/Agronomy/Biology 585, Plant Cell, Tissue and Organ Culture, 3 credits, New Mexico State University, Fall 1991, Spring 1994, Spring 1996, Fall 1998, Spring 2001, Spring 2003

Agronomy/Animal Science/Biology/Horticulture 305, Principles of Genetics, 3 credits, New Mexico State University, Fall 1992, Fall 1993, Fall 1994, Fall 1995, Fall 1996

Molecular Biology 597, Laboratory Rotations/Research Discussions, Fall 1992, Spring 1993, Fall 1993, Spring 1994, Fall 1994, Spring 1995, Fall 1995, Spring 1996, Fall 1996, Spring 1997, Fall 1997, Spring 1998, Fall 1998, Spring 1999

Molecular Biology 690, Current Topics in Molecular Biology, Fall 1992, Spring 1993, Fall 1993, Spring 1994, Fall 1994, Spring 1995, Fall 1995, Spring 1996, Fall 1996, Spring 1997, Fall 1997, Spring 1998, Fall 1998, Spring 1999

Agricultural Genetics (short courses), Academy for Learning in Retirement, Spring 1995

Agronomy/Horticulture/Soil Science 447, Undergraduate Seminar, Fall 2001, Spring 2002, Fall 2002, Spring 2003 Agronomy/Horticulture/Soil Science 590, Graduate Seminar, Fall 2001, Spring 2002, Fall 2002, Spring 2003 Agriculture 6902, Biotechnology in Crop Agriculture, Spring 2004 Agriculture 3711, Seminar in Agriculture: Information Literacy, Fall 2004 Agriculture 3721, Seminar in Agriculture: Research Interpretation, Spring 2005, Spring 2006 Agriculture 4721, Seminar in Agriculture: Professional Presentations, Fall 2005 Agriculture 3723, Seminar in Agriculture: Technical & Professional Skills, Fall 2007, Spring 2008, Fall 2008, Spring 2009 Agriculture 6351, Graduate Seminar: Orientation, Fall 2008

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Guest Lectures

HORT 250, Plant Propagation, NMSU, Fall 1981, Fall 1982, Spring 1984, Spring 1992, Spring 1994, Spring 1995, Spring 1997, Spring 1998

AXED 110, Modern Agriculture, NMSU, Fall 1982 HORT 201, Plant Science Techniques, NMSU, Spring 1984

Board of Regents Special Program, Frontiers of Science, NMSU, Summer 1986, Summer 1987 CHEM 649, Plant Biochemistry, NMSU, Spring 1987, Spring 1988 HORT 431, Nursery Crops, NMSU, Fall 1988

AGRO 462L, Plant Breeding Lab, NMSU, Fall 1991 MOLB 520, Molecular Cell Biology, NMSU, Spring 1995, Fall 1997, Fall 1998, Fall 1999

AGRO 685, Plant Genetic Engineering, NMSU, Spring 1994 HORT 532, Plant Physiology: Growth and Development, Spring 1997 Computational Science Workshop, Fall 1997 AGRO 698, Biotechnology for Plant Breeders, Fall 2000 BIOL 560, Cell and Organismal Biology Seminar, Spring 2002 Undergraduate Students Director of 29 Special Research Problems Advised 7 students in Horticulture: Plant Genetics Option Supervised 49 Laboratory Research Aides Graduate Students Juan Jose Ramirez, M.S., 1983, pecan tissue culture (employed by INIA, Mexico) David W. Still, M.S., 1985, desert willow tissue culture (Ph.D., Texas A&M Univ.) Julia M. Gourd, M.S., 1986, in vitro onion resistance to pink root toxins (USDA, Beltsville)

Heather J. Gladfelter, M.S., eldarica pine tissue culture, 1987 (Westvaco, Summerville, SC) Philip W. Clayton, M.S., 1987, cactus micropropagation (US Fish and Wildlife) Judith Corte-Olivares, M.S., 1987, pecan tissue culture (Orchids and Ferns Co., Houston) Rebecca M. Sellars, M.S., 1987, peanut tissue culture (NMSU Foundation) Kent J. Luteyn, M.S., 1989, onion pink root greenhouse screening (US Border Patrol) Andrew C. Ludwig, M.S., 1989, onion tissue culture screening for pink root resistance (Univ. of

Florida, Lake Alfred) Rosalia Velasquez, M.S., 1990, onion and pepper protoplast culture (PRODETEC, Venezuela) Benjamin C. Eggett, M.S., 1991, tobacco cell selection to alter polyamines and alkaloids (Univ. of Tennessee, Greenville)

Ming Cheng, Ph.D., 1993, peanut regeneration and genetic transformation (Monsanto Co., Mystic, CT)

Elizabeth E. Hansen, M.S., 1993, onion protoplast culture and fusion (Lab of Nobel Laureate Dr. Philip Sharp, MIT)

Raul Saavedra, Ph.D., 1994, cotton cell selection for overproduction of uncommon polyamines (ICA, Colombia) Rakesh Kuruba, M.S., 1996, genetic transformation of alfalfa (PowerSolve, Inc., Alexandria,

VA) Ahmed El-Sharif, Ph.D., 1997, genetic transformation of onion by particle acceleration (Agricultural Research Centre, Egypt)

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Isaac Reyes, M.S., 1997, cellular morphogenesis of endangered cacti (Ph.D. candidate, NMSU) Subramani Jayashankar, Ph.D., 1998, genetic transformation of pepper (Univ. of Arizona,

Maricopa) Hu Wei, Ph.D., 1999, transgenic expression in tomato of polyamine oxidase gene (freelance

programmer and web site developer, CA) Luis Valera-Montero, Ph.D., 2003, novel regeneration system and genetic transformation of

pepper (ICT, Aguascalientes, Mexico) Michael Greenway, M.S., current, BDS basal medium as general improvement over B5

Post-doctoral Students Yan-San Chyi, 1984-1987, tomato transformation (Mycogen, Inc.) Benjamin Rodriguez-Garay, 1985-1988, plant polyamines and stress tolerance (CIATEJ,

Mexico) Suman Bagga, 1988-1991, plant uncommon polyamine biochemistry and relation to stress tolerance (PGEL, NMSU) Govindan Balakrishnamurthy, 1989-1991, tomato and onion protoplast culture (Tamil Nadu Agricultural Univ., India) Camille Hyde, 1992-1993, pepper regeneration in vitro (freelance writer)

Niu Dong, 1993-1998, antifungal gene constructs and gene transfer in onion (USDA-ARS) Richard Richins, 1999-2002, plant genomics (NMSU) X. Current Research Funding Arkansas Biosciences Institute Metabolic engineering for rice nutritional improvement 07-01-03 to 06-30-09 PI: G.C. Phillips (10%) $330,000 total My research career grantsmanship, including all grants and contracts as sole PI as well as a pro- rata proportion of grants and contracts as a co-PI, totals $6,372,571. Grants have been received from USDA, DOD, USGS, WRRI, NIH, other federal and state agencies, and private companies. XI. Publications Refereed Journal Articles 1. Phillips, G.C. and G.B. Collins. 1977. The influence of genotype and environment on

haploid plant production from anther cultures of Nicotiana tabacum. Tob. Sci. 21:112-116. 2. Collins, G.B., W.E. Vian, and G.C. Phillips. 1978. Use of 4-amino-3,5,6-

trichloropicolinic acid as an auxin source in plant tissue cultures. Crop Sci. 18:286-288. 3. Phillips, G.C. and G.B. Collins. 1979. In vitro tissue culture of selected legumes and

plant regeneration from callus cultures of red clover. Crop Sci. 19:59-64. 4. Phillips, G.C. and G.B. Collins. 1979. Virus symptom-free plants of red clover using

meristem culture. Crop Sci. 19: 213-216.

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5. Phillips, G.C. and G.B. Collins. 1980. Somatic embryogenesis from cell suspension cultures of red clover. Crop Sci. 20: 323-326.

6. Phillips, G.C. and G.B. Collins. 1981. Induction and development of somatic embryos

from cell suspension cultures of soybean. Plant Cell Tissue Organ Culture 1:123-129. 7. Phillips, G.C., G.B. Collins, and N.L. Taylor. 1982. Interspecific hybridization of red

clover (Trifolium pratense L.) with T. sarosiense Hazsl. using in vitro embryo rescue. Theor. Appl. Genet. 62:17-24.

8. Phillips, G.C. and K.J. Luteyn. 1983. Effects of picloram and other auxins on onion

tissue cultures. J. Amer. Soc. Hort. Sci. 108:948-953. 9. Phillips, G.C. and J.F. Hubstenberger. 1985. Organogenesis in pepper tissue cultures.

Plant Cell Tissue Organ Culture 4: 261-269. 10. Phillips, G.C. and J.F. Hubstenberger. 1987. Plant regeneration in vitro of selected

Allium species and interspecific hybrids. HortScience 22:124-125. 11. Chyi, Y.S. and G.C. Phillips. 1987. High efficiency Agrobacterium-mediated

transformation of Lycopersicon based on conditions favorable for regeneration. Plant Cell Reports 6: 105-108.

12. Gladfelter, H.J. and G.C. Phillips. 1987. De novo shoot organogenesis of Pinus eldarica

Medw. in vitro. I. Reproducible regeneration from long-term callus cultures. Plant Cell Reports 6:163-166.

13. Wagley, L.M., H.J. Gladfelter, and G.C. Phillips. 1987. De novo shoot organogenesis of

Pinus eldarica Medw. in vitro. II. Macro- and micro-photographic evidence of de novo regeneration. Plant Cell Reports 6:167-171.

14. Gourd, J., G.M. Southward, and G.C. Phillips. 1988. Response of Allium tissue cultures

to filtrates of Pyrenochaeta terrestris. HortScience 23:766-768. 15. Rodriguez-Garay, B., G.C. Phillips, and G.D. Kuehn. 1989. Detection of norspermidine

and norspermine in Medicago sativa L. (alfalfa). Plant Physiol. 89:525-529. 16. Munyon, I.P., J.F. Hubstenberger, and G.C. Phillips. 1989. Origin of plantlets and callus

obtained from chile pepper anther cultures. In Vitro Cell. Devel. Biol. 25:293-296. 17. Clayton, P.W., J.F. Hubstenberger, G.C. Phillips, and S.A. Butler-Nance. 1990.

Micropropagation of members of the Cactaceae subtribe Cactinae. J. Amer. Soc. Hort. Sci. 115:337-343.

18. Sellars, R.M., G.M. Southward, and G.C. Phillips. 1990. Adventitious somatic

embryogenesis from cultured immature zygotic embryos of peanut and soybean. Crop Sci. 30:408-414.

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19. Corte-Olivares, J., G.C. Phillips, and S.A. Butler-Nance. 1990. Somatic embryogenesis from pecan zygotic embryo explants. HortScience 25:983.

20. Corte-Olivares, J., G.C. Phillips, and S.A. Butler-Nance. 1990. Micropropagation of

pecan. HortScience 25:1308. 21. Kuehn, G.D., B. Rodriguez-Garay, S. Bagga, and G.C. Phillips. 1990. Novel occurrence

of uncommon polyamines in higher plants. Plant Physiol. 94:855-857. 22. Liu, W., D.F. Hildebrand, W.S. Grayburn, G.C. Phillips, and G.B. Collins. 1990. Effects

of exogenous auxins on expression of lipoxygenases in cultured soybean embryos. Plant Physiol. 97:969-976.

23. Bagga, S., A. Dharma, G.C. Phillips, and G.D. Kuehn. 1991. Evidence for the

occurrence of polyamine oxidase in the dicotyledonous plant Medicago sativa L. (alfalfa). Plant Cell Reports 10:550-554.

24. Ludwig, A.C., J.F. Hubstenberger, G.C. Phillips, and G.M. Southward. 1992. Screening

of Allium tester lines in vitro with Pyrenochaeta terrestris filtrates. HortScience 27:166-168. 25. Phillips, G.C., B.C. Eggett, and G.B. Collins. 1992. Effects of polyamine metabolic

inhibitors on growth and alkaloid accumulation in tobacco callus cultures. Tobacco Sci. 36:1-5. 26. Woods, S.H., G.C. Phillips, J.E. Woods, and G.B. Collins. 1992. Somatic

embryogenesis and plant regeneration from zygotic explants in Mexican Weeping Bamboo. Plant Cell Reports 11: 257-261.

27. Phillips, G.C., J.W. Grosser, S. Berger, N.L. Taylor, and G.B. Collins. 1992.

Interspecific hybridization between red clover and Trifolium alpestre using in vitro embryo rescue. Crop Sci. 32:1113-1115.

28. Cheng M., D.C.H. Hsi, and G.C. Phillips. 1992. In vitro regeneration of valencia-type

peanut (Arachis hypogaea L.) from cultured petiolules, epicotyl sections and other seedling explants. Peanut Sci. 19:82-87.

29. Cheng, M., D.C.H. Hsi, and G.C. Phillips. 1994. Recovery of primary transformants of

valencia-type peanut using Agrobacterium tumefaciens. Peanut Science 22:84-88. 30. Hansen, E.E., J.F. Hubstenberger, and G.C. Phillips. 1995. Regeneration of shoots from

cell suspension-derived protoplasts of Allium cepa L. Plant Cell Reports 15:8-11. 31. Hyde, C. and G.C. Phillips. 1996. Silver nitrate promotes shoot development and plant

regeneration of chile pepper (Capsicum annuum L.) via organogenesis. In Vitro Cell. Devel. Biol. - Plant 32:72-80.

32. Bagga, S., J. Rochford, Z. Klaene, G.D. Kuehn, and G.C. Phillips. 1997. Putrescine

aminopropyltransferase is responsible for biosynthesis of spermidine, spermine and multiple uncommon polyamines in osmotic stress-tolerant alfalfa. Plant Physiol. 114:445-454.

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33. Koc, E., S. Bagga, D.D. Songstad, S.R. Betz, G.D. Kuehn, and G.C. Phillips. 1998.

Occurrence of uncommon polyamines in cultured tissues of maize. In Vitro Cell. Devel. Biol. - Plant 34:252-255.

34. Lucero, M.E., W. Mueller, J. Hubstenberger, G.C. Phillips, and M.A. O'Connell. 1999.

Tolerance to nitrogenous explosives and metabolism of TNT by cell suspensions of Datura innoxia. In Vitro Cell. Devel. Biol. - Plant 35:480-486.

35. Hu, W., and G.C. Phillips. 2001. A combination of overgrowth-control antibiotics

improves Agrobacterium tumefaciens-mediated transformation efficiency for cultivated tomato (L. esculentum). In Vitro Cell. Devel. Biol. - Plant 37:12-18.

36. Phillips, G.C. 2004. In vitro morphogenesis in plants - recent advances. In Vitro Cell. Devel. Biol. – Plant 40:346-358. (Reprint of: Encyclopedia of Plant and Crop Science, R.M. Goodman (ed), Vol. 1, part 7, pp. 579-583. Marcel Dekker, Inc., New York.)

37. Valera-Montero, L. and G.C. Phillips. 2005. Long-lasting Capsicum baccatum

‘organogenetic callus’ formation. In Vitro Cell. Devel. Biol. – Plant 41: 470-476.

38. Kuehn, G.D. and G.C. Phillips. 2005. Role of polyamines in apoptosis and other recent advances in plant polyamines. Crit. Rev. Plant Sci. 24:1-8.

39. Roy Chowdhury, M., A. Dabul, J. Hubstenberger, and G.C. Phillips. 2006. Development

of in vitro regeneration protocols for Arkansas rice varieties (Oryza sativa L.). J. Arkansas Acad. Sci. 60:108-112.

40. Dabul, A.N.G., H. Belefant-Miller, M. RoyChowdhury, J.F. Hubstenberger, A. Lorence, and G.C. Phillips. 2008. Screening of a broad range of rice (Oryza sativa L.) germplasm for in vitro rapid plant regeneration and development of an early prediction system. In Vitro Cell. Devel. Biol. – Plant 44 (In press).

41. Armah, P., A. Archer, and G.C. Phillips. 2009. Drivers leading to higher food prices:

Biofuels are not the main culprit. (Invited article) In Vitro Cell. Devel. Biology – Plant: Special Issue on Biofuels 45 (In press).

Chapters in Books and Published Symposia 1. Collins, G.B. and G.C. Phillips. 1982. In vitro tissue culture and plant regeneration in

Trifolium pratense L. In: Variability in Plants Regenerated from Tissue Cultures, E.D. Earle and Y. Demarly (eds), pp. 22-34. Praeger Scientific, New York.

2. Collins, G.B., N.L. Taylor, and G.C. Phillips. 1983. Successful hybridization of red

clover with perennial Trifolium species via embryo rescue. Fourteenth Internat. Grassl. Cong. Proc., A. Smith and V. Hays (eds), pp. 168-170. Westview Press, Boulder, CO.

3. Phillips, G.C. and J.J. Ramirez. 1983. Pecan tissue culture. Seventeenth Western Pecan

Conf. Proc., E. Herrera-Aguirre (ed), pp. 101-109. New Mexico State Univ. Coop. Ext. Serv.,

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Las Cruces, NM. 4. Phillips, G.C. and G.B. Collins. 1984. Red clover and other forage legumes. In:

Handbook of Plant Cell Culture, Vol. 2, D.A. Evans, W.R. Sharp, P.V. Ammirato, and Y. Yamada (eds), pp. 169-210. MacMillan Publ., New York.

5. Phillips, G.C. 1985. Genetic engineering for drought tolerance. Symposium: Water and

Science Proc., L. Harris (ed), pp. 76-84. New Mexico Water Resources Research Institute, Las Cruces, NM.

6. Phillips, G.C. and H.G. Herrera. 1985. Asexual reproduction of the Afghan pine through

tissue culture. Afghan Pine and Christmas Tree Symposium 1985 Proc., F.B. Widmoyer (ed), pp. 46-49. New Mexico State Univ., Las Cruces, NM.

7. Hildebrand, D.F., G.C. Phillips, and G.B. Collins. 1986. Soybeans [Glycine max (L.)

Merr.]. In: Biotechnology in Agriculture and Forestry, Vol. 2, Crops I, Y.P.S. Bajaj (ed), pp. 283-308. Springer-Verlag, Heidelberg.

8. Gladfelter, H.J., G.C. Phillips, and J.D. Kemp. 1987. Trees of the future: tissue culture

cloning and genetic engineering. Afghan Pine and Christmas Tree Symposium 1986 Proc., F.B. Widmoyer (ed), pp. 31-37. New Mexico State Univ., Las Cruces, NM.

9. Clayton, P.W., J.F. Hubstenberger, S.A. Butler-Nance, and G.C. Phillips. 1987. Tissue

culture cloning of native cacti: implications for conservation or commercialization. Proc. Southwestern Native Plant Symp., L. Johnston and J. Phillips (eds), pp. 77-79. Native Plant Society of New Mexico, Belen, NM.

10. Fisher, J.T., J.G. Mexal, and G.C. Phillips. 1988. High value crops from New Mexico

pinyon pines. I. Crop improvement through woodland stand management. In: Pinyon-Juniper Woodlands of New Mexico: A Biological and Economic Appraisal, NM Agric. Exper. Sta. Special Report 73, J.T. Fisher, J.G. Mexal, and R.D. Pieper (eds), pp. 13-23. New Mexico State Univ., Las Cruces, NM.

11. Phillips, G.C., J.T. Fisher, and J.G. Mexal. 1988. High value crops from New Mexico

pinyon pines. II. Crop improvement through biotechnology. In: Pinyon-Juniper Woodlands of New Mexico: A Biological and Economic Appraisal, NM Agric. Exper. Sta. Special Report 73, J.T. Fisher, J.G. Mexal, and R.D. Pieper (eds), pp. 39-44. New Mexico State Univ., Las Cruces, NM.

12. Phillips, G.C. 1988. Developmental models for the expression of totipotency and plant

regeneration in vitro. In: SAAS Bulletin: Biochemistry and Biotechnology, Vol. 1, S.K. Ballal (ed), pp. 12-16. Tennessee Tech. Univ., Cookeville, TN.

13. Kuehn, G.D., S. Bagga, B. Rodriguez-Garay, and G.C. Phillips. 1990. Biosynthesis of

uncommon polyamines in higher plants and their relation to abiotic stress responses. In: Polyamines and Ethylene: Biosynthesis, Physiology, and Interactions, H.E. Flores, R.N. Arteca, and J.C. Shannon (eds), pp. 190-202. Amer. Soc. Plant Physiologists, Rockville, MD.

23

14. Phillips, G.C. and H.J. Gladfelter. 1991. Eldarica pine, Afghan pine (Pinus eldarica Medw.). In: Biotechnology in Agriculture and Forestry, Vol. 16, Trees III, Y.P.S. Bajaj (ed), pp. 269-287. Springer-Verlag, Heidelberg.

15. Phillips, G.C. and G.D. Kuehn. 1991. Uncommon polyamines in plants and other

organisms. In: Biochemistry and Physiology of Polyamines in Plants, R.D. Slocum and H.E. Flores (eds), pp. 121-136. CRC Uniscience, Boca Raton, FL.

16. Hubstenberger, J.F., P.W. Clayton, and G.C. Phillips. 1992. Micropropagation of cacti

(Cactaceae). In: Biotechnology in Agriculture and Forestry, Vol. 20, High-Tech and Micropropagation IV, Y.P.S. Bajaj (ed), pp. 49-68. Springer-Verlag, Heidelberg.

17. Phillips, G.C. 1993. Micropropagation of rare and endangered cacti: applications in

conservation and commerce. In: Biotechnology for Aridland Plants, T.J. Mabry, H.T. Nguyen, R.A. Dixon, and M.S. Bonness (eds), pp. 135-152. IC2 Institute, Univ. of Texas at Austin, Austin, TX.

18. Phillips, G.C. 1994. Plant genetic engineering research at NMSU. In: The Importance

of Agricultural Science in New Mexico's Economy, E. Herrera (ed), NM J. Sci. 34:119-125. New Mexico Academy of Sciences, Albuquerque, NM.

19. Gamborg, O.L. and G.C. Phillips. 1995. Laboratory facilities, operation and

management. In: Plant Cell, Tissue and Organ Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 3-20. Springer-Verlag, Heidelberg.

20. Gamborg, O.L. and G.C. Phillips. 1995. Media preparation and handling. In: Plant

Cell, Tissue and Organ Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 21-34. Springer-Verlag, Heidelberg.

21. Gamborg, O.L. and G.C. Phillips. 1995. Sterile techniques. In: Plant Cell, Tissue and

Organ Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 35-42. Springer-Verlag, Heidelberg.

22. Phillips, G.C. and J.F. Hubstenberger. 1995. Micropropagation by proliferation of

axillary buds. In: Plant Cell, Tissue and Organ Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 45-54. Springer-Verlag, Heidelberg.

23. Phillips, G.C., J.F. Hubstenberger, and E.E. Hansen. 1995. Adventitious shoot

proliferation. In: Plant Cell, Tissue and Organ Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 55-65. Springer-Verlag, Heidelberg.

24. Phillips, G.C., J.F. Hubstenberger, and E.E. Hansen. 1995. Plant regeneration by

organogenesis from callus and cell suspension cultures. In: Plant Cell, Tissue and Organ Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 67-79. Springer-Verlag, Heidelberg.

25. Phillips, G.C., J.F. Hubstenberger, and E.E. Hansen. 1995. Plant regeneration from

callus and cell suspension cultures by somatic embryogenesis. In: Plant Cell, Tissue and Organ

24

Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 81-90. Springer-Verlag, Heidelberg.

26. Phillips, G.C. and O.L. Gamborg. 1995. Glossary of terms used in plant cellular and

developmental biology. In: Plant Cell, Tissue and Organ Culture - Fundamental Methods, O.L. Gamborg and G.C. Phillips (eds), pp. 337-348. Springer-Verlag, Heidelberg.

27. Hansen, E.E., J.F. Hubstenberger, and G.C. Phillips. 1996. Regeneration of plantlets

from protoplasts of Allium cepa (onion). In: Biotechnology in Agriculture and Forestry, Vol. 38, Plant Protoplasts and Genetic Engineering VII, Y.P.S. Bajaj (ed), pp. 3-13. Springer-Verlag, Heidelberg.

28. Phillips, G.C., M.A. O’Connell, I.M. Ray, R.G. Cantrell, and C. Sengupta-Gopalan. 1999. The importance of plant biotechnology in the future development of arid lands. In: Ensuring Sustainable Development of Arid Lands through Time, E.A. Herrera and J.G. Mexal (eds), NM J. Sci. 39:310-339. New Mexico Academy of Sciences, Albuquerque, NM.

29. Phillips, G.C. 2004. In vitro morphogenesis in plants - recent advances. In: Encyclopedia of Plant and Crop Science, R.M. Goodman (ed), Vol. 1, part 7, pp. 579-583. Marcel Dekker, Inc., New York.

30. O’Connell, M.A., R. Richins, P.W. Bosland, G.C. Phillips, and L. Valera-Montero.

2004. Red or green? A molecular genetics answer to the state question of New Mexico. NM J. Sci., vol. 44. New Mexico Academy of Sciences, Albuquerque, NM.

Technical Reports 1. Tanksley, S.D. and G.C. Phillips. 1985. Evaluation of the potential for the genetic

improvement of salt tolerance in chile pepper (Capsicum annuum) using wild germplasm and cell selection procedures. Technical Completion Report No. 187, New Mexico Water Resources Research Institute, Las Cruces, NM.

2. Phillips, G.C. 1987. Somatic cell selection criteria for water use efficiency using

genetically differential alfalfas. Technical Completion Report No. 221, New Mexico Water Resources Research Institute, Las Cruces, NM.

3. Phillips, G.C., P.W. Clayton, and J.F. Hubstenberger. 1987. A study of the rooting and

re-establishment of Pediocactus knowltonii propagules derived from tissue culture. Technical Completion Report Cooperative Agreement 14-16-0002-86-916, U.S. Fish and Wildlife Service.

4. Phillips, G.C., R. Saavedra, and G.D. Kuehn. 1994. Somatic cell selection to genetically improve water use efficiency and tolerances to stresses. Technical Completion Report No. 289, New Mexico Water Resources Research Institute, Las Cruces, NM.

5. Peffley, E.B., M.A. Hart, T.A. Wheeler, Z. Xiang, A. El-Sharif, N. Dong, and G.C.

Phillips. 1995. Progress towards transformation of onion, Allium cepa and A. fistulosum, via particle bombardment. Allium Improvement Newsletter 5:14-16.

25

6. Dong, N., J.F. Hubstenberger, and G.C. Phillips. 1997. Apparent transformation of Allium fistulosum suspension cultures by Agrobacterium tumefaciens. Allium Improvement Newsletter 7:12-14.

7. Phillips, G.C. 1999. Final Report: “Plant biotechnology: cellular imaging and manipulation instrumentation.” Department of Defense, Army Research Office, DURIP Agreement DAAG55-97-1-0088.

Books 1. Gamborg, O.L. and G.C. Phillips (eds). 1995. Plant Cell, Tissue and Organ Culture -

Fundamental Methods. Springer-Verlag, Heidelberg, 358 pp. Book Reviews 1. O'Connell, M.A. and G.C. Phillips. 1991. Agricultural Bioethics: Implications of

Agricultural Biotechnology. Quart. Rev. Biol. 66(3):342. Magazine Articles 1. Phillips, G.C. 1987. Cloning cacti by tissue culture. Greenhouse Grower 5(4):52,55. World Wide Web Pages 1. Burlbaw, E., D. Bustamante, M. O'Connell, G. Phillips, et al. 1996-1998. National

Biotechnology Information Facility. http://www.nbif.org (25 pp.) Other Publications (Abstracts) 1. Phillips, G.C. and G.B. Collins. 1977. In vitro tissue culture and plant regeneration from

callus tissue of Trifolium pratense. Agron. Abstr. 1977:67. 2. Phillips, G.C. and G.B. Collins. 1978. Symptomless plants from virus-infected red

clover (Trifolium pratense) clones via shoot meristem-tip culture. Agron. Abstr. 1978:83. 3. Phillips, G.C. and G.B. Collins. 1979. Cell suspension cultures and plant regeneration in

red clover. Sixth Trifolium Conf. Min., p. 85. 4. Phillips, G.C., G.B. Collins, and N.L. Taylor. 1979. Virus elimination and rapid

multiplication of red clover plants using meristem culture. Sixth Trifolium Conf. Min., p. 87. 5. Collins, G.B., G.C. Phillips, and G.J. Keyes. 1979. Somatic embryogenesis and efficient

plant regeneration in red clover (Trifolium pratense L.). Agron. Abstr. 1979:59. 6. Phillips, G.C., G.B. Collins, and N.L. Taylor. 1980. The use of in vitro embryo rescue

for the hybridization of Trifolium sarosiense and T. pratense. Agron. Abstr. 1980:65. 7. Phillips, G.C. and G.B. Collins. 1981. Growth and selection of red clover (Trifolium

26

pratense L.) cells on low levels of phosphate. Agron. Abstr. 1981:187. 8. Phillips, G.C. 1982. Use of picloram as auxin in onion (Allium cepa) tissue cultures.

Beltsville Symposium VII: Genetic Engineering: Applications to Agriculture, Abstr. 56. 9. Luteyn, K.J. and G.C. Phillips. 1982. Auxin effects on onion (Allium cepa) tissue

cultures. HortScience 17:531. 10. Phillips, G.C. 1983. Screening alfalfas adapted to the southwestern United States for

regenerator genotypes. In Vitro 19:265. 11. Phillips, G.C. and G.B. Collins. 1983. The use of picloram for crop plant regeneration in

vitro. Agron. Abstr. 1983:76. 12. Phillips, G.C. and J.F. Hubstenberger. 1984. Adventitious budding and organogenesis in

tissue cultures of chile pepper (Capsicum annuum L.). In Vitro 20:277. 13. Phillips, G.C., S.D. Tanksley, I. Munyon, and J.F. Hubstenberger. 1984. The influence

of incubation environment and genotype on anther culture of chile pepper (Capsicum annuum L.). In Vitro 20:277.

14. Herrera, H.G. and G.C. Phillips. 1985. Tissue culture of Pinus eldarica (Med.). In:

Tissue Culture in Forestry and Agriculture, R.R. Henke, K.W. Hughes, M.J. Constantin, and A. Hollaender (eds), pp. 322-323. Plenum Press, New York.

15. Still, D.W., J.F. Hubstenberger, G.C. Phillips, and R.F. Hooks. 1985. Clonal

propagation of Chilopsis linearis (Cav.) through tissue culture. In: Tissue Culture in Forestry and Agriculture, R.R. Henke, K.W. Hughes, M.J. Constantin, and A. Hollaender (eds), pp. 354-355. Plenum Press, New York.

16. Phillips, G.C. 1985. Plant regeneration from Allium species cultured in vitro. In Vitro

Cell. Devel. Biol. 21:24A. 17. Rodriguez-Garay, B., J.R. Barrow, and G.C. Phillips. 1986. Heat and drought tolerant

cotton lines tolerate induced water and salinity stresses in vitro. In: Sixth Internat. Cong. Plant Tissue and Cell Culture Abstr., D.A. Somers, B.G. Gengenbach, D.D. Biesboer, W.P. Hackett, and C.E. Green (eds), p. 62. Univ of Minnesota, Minneapolis, MN.

18. Herrera, H.G., L.M. Wagley, and G.C. Phillips. 1986. De novo plantlet regeneration

from long-term callus cultures of Pinus eldarica Medw. In: Sixth Internat. Cong. Plant Tissue and Cell Culture Abstr., D.A. Somers, B.G. Gengenbach, D.D. Biesboer, W.P. Hackett, and C.E. Green (eds), p. 266. Univ. of Minnesota, Minneapolis, MN.

19. Gourd, J. and G.C. Phillips. 1986. Inoculation of Allium tissue cultures with

Pyrenochaeta terrestris filtrates. In: Sixth Internat. Cong. Plant Tissue and Cell Culture Abstr., D.A. Somers, B.G. Gengenbach, D.D. Biesboer, W.P. Hackett, and C.E. Green (eds), p. 302. Univ. of Minnesota, Minneapolis, MN.

27

20. Clayton, P.W., J.F. Hubstenberger, S.A. Butler-Nance, and G.C. Phillips. 1986. Micropropagation of endangered species of Pediocactus, Sclerocactus and Toumeya. In: Sixth Internat. Cong. Plant Tissue and Cell Culture Abstr., D.A. Somers, B.G. Gengenbach, D.D. Biesboer, W.P. Hackett, and C.E. Green (eds), p. 427. Univ. of Minnesota, Minneapolis, MN.

21. Clayton, P.W., J.F. Hubstenberger, and G.C. Phillips. 1986. Micropropagation potential

of rare or endangered cacti. HortScience 21:868. 22. Rodriguez-Garay, B., G.D. Kuehn, G.C. Phillips, C.J. Lovatt, and C.G. Currier. 1987.

Biochemical indices of water-deficiency and heat-stress tolerances in plants. Second Annual Symp. Southwest Consortium on Plant Genetics and Water Resources, p. 20. Plant Genetic Engineering Laboratory, Las Cruces, NM.

23. Rodriguez-Garay, B., G.D. Kuehn, G.C. Phillips, C.J. Lovatt, and C.G. Currier. 1987.

Biochemical indices of tolerance and susceptibility in leaf tissues of drought-stressed alfalfas and heat-stressed cottons. Agron. Abstr. 1987:99.

24. Phillips, G.C., B. Rodriguez-Garay, G.D. Kuehn, and C.J. Lovatt. 1987. Patterns of

ammonia and polyamine accumulations in cell cultures of water deficit-stressed alfalfas and heat-stressed cottons. Agron. Abstr. 1987:152.

25. Herrera, H.G. and G.C. Phillips. 1988. Regeneration potential of Afghan pine. In:

Forest and Crop Biotechnology, F.A. Valentine (ed), pp. 424-425. Springer-Verlag, New York. 26. Gladfelter, H.J. and G.C. Phillips. 1988. Pinus eldarica de novo shoot organogensis

refined and applied to other conifers. In: Genetic Manipulation of Woody Plants, J.W. Hanover and D.E. Keathley (eds), p. 468. Plenum Press, New York.

27. Phillips, G.C., B. Rodriguez-Garay, C.J. Lovatt, C.G. Currier, and G.D. Kuehn. 1988.

Key biosynthetic enzymes involved in plant abiotic stress tolerances: ammonia detoxication and polyamine syntheses. Third Annual Symp. Southwest Consortium on Plant Genetics and Water Resources, p. 18. Plant Genetic Engineering Laboratory, Las Cruces, NM.

28. Rodriguez-Garay, B., G.D. Kuehn, C.G. Currier, and G.C. Phillips. 1988. Polyamines as

indices of tolerance and susceptibility in leaf tissues of drought-stressed alfalfas. Third Annual Symp. Southwest Consortium on Plant Genetics and Water Resources, p. 36. Plant Genetic Engineering Laboratory, Las Cruces, NM.

29. Sellars, R.M., G.M. Southward, and G.C. Phillips. 1988. Adventitious somatic

embryogenesis from cultured immature sexual embryos of Arachis hypogaea L. compared to Glycine max (L.) Merr. Agron. Abstr. 1988:173.

30. Kuehn, G.D., B. Rodriguez-Garay, C.J. Lovatt, and G.C. Phillips. 1989. Nitrogen

metabolism which correlates with drought and heat tolerances in plants. Fourth Annual Symp. Southwest Consortium on Plant Genetics and Water Resources, p. 3. Plant Genetic Engineering Laboratory, Las Cruces, NM.

31. Rodriguez-Garay, B., G.C. Phillips, and G.D. Kuehn. 1989. Biosynthesis of uncommon

28

polyamines: potential role in plant tolerances to drought and heat. Proc. Sixty-fifth Annual Meeting Southwestern and Rocky Mountain Division AAAS, p. 13. Colorado Mountain College, Glenwood Springs, CO.

32. Phillips, G.C., P.W. Clayton, and J.F. Hubstenberger. 1989. Micropropagation of

threatened and endangered species of the Cactaceae. In Vitro Cell. Devel. Biol. 25:39A. 33. Bagga, S., G.D. Kuehn, and G.C. Phillips. 1989. Polyamine oxidase and

aminopropyltransferase enzymes involved in biosynthesis of uncommon polyamines in alfalfa. Agron. Abstr. 1989:173.

34. Kuehn, G.D., S. Bagga, and G.C. Phillips. 1990. Evidence for the occurrence of

polyamine oxidase in a dicotyledonous plant, Medicago sativa L. (alfalfa). Fifth Annual Symp. Southwest Consortium on Plant Genetics and Water Resources, p. 13. Plant Genetic Engineering Laboratory, Las Cruces, NM.

35. Balakrishnamurthy, G., G.C. Phillips, and M.A. O'Connell. 1990. Isolation and culture

of Allium protoplasts. VIIth Internat. Congr. Plant Tissue and Cell Culture, p. 7. Internat. Assoc. Plant Tissue Cult., Amsterdam.

36. Bagga, S., G.C. Phillips, and G.D. Kuehn. 1990. Studies on polyamine oxidase and

aminopropyl transferase enzymes for biosynthesis of uncommon polyamines in alfalfa. VIIth Internat. Congr. Plant Tissue and Cell Culture, p. 226. Internat. Assoc. Plant Tissue Cult., Amsterdam.

37. Liu, W., D.F. Hildebrand, G.C. Phillips, and G.B. Collins. 1990. Changes in

lipoxygenases and fatty acids during embryogenesis and somatic embryo development in soybean. Plant Physiol. 93:S-139.

38. Phillips, G.C., B.C. Eggett, and G.B. Collins. 1990. Inhibitors of polyamine

biosynthesis that affect growth and alkaloid accumulation in tobacco callus cultures. Agron. Abstr. 1990:201-202.

39. Kuehn, G.D., S. Bagga, A. Dharma, C.J. Lovatt, and G.C. Phillips. 1991. Uncommon polyamines in drought-tolerant alfalfa strains: a novel biosynthetic route. Sixth Annual Symp. Southwest Consortium on Plant Genetics and Water Resources. Plant Genetic Engineering Laboratory, Las Cruces, NM.

40. Bagga, S., A. Dharma, G.C. Phillips, and G.D. Kuehn. 1991. Evidence for a new biosynthetic pathway for uncommon polyamines in Medicago sativa L. (alfalfa). Sixth Annual Symp. Southwest Consortium on Plant Genetics and Water Resources. Plant Genetic Engineering Laboratory, Las Cruces, NM.

41. Bagga, S., G.C. Phillips, and G.D. Kuehn. 1991. Unique enzyme activities for

polyamine biosynthesis in drought-tolerant alfalfa. Third International Congress of Plant Molecular Biology, October 6-12, 1991, Tucson, AZ, Abstr. 1559.

42. Cheng, M., D.C.H. Hsi, and G.C. Phillips. 1992. Development of in vitro regeneration

29

approaches for valencia-type peanut (Arachis hypogaea L.) suitable for Agrobacterium-mediated transformation. American Peanut Research and Education Society Annual Meeting, July 7-10, 1992, Norfolk, VA.

43. Bagga, S., A. Dharma, R. Saavedra, L. Martinez, R. Sanchez, G.C. Phillips, and G.D.

Kuehn. 1992. Enzymatic and genetic characterization of polyamine biosynthesis in abiotically-stressed plant systems. Seventh Annual Symp. Southwest Consortium on Plant Genetics and Water Resources. Plant Genetic Engineering Laboratory, Las Cruces, NM, p. 10.

44. Dharma, A., S. Bagga, G.C. Phillips, and G.D. Kuehn. 1992. Purification of polyamine

oxidase and its genetic characterization in drought-tolerant alfalfa. Seventh Annual Symp. Southwest Consortium on Plant Genetics and Water Resources. Plant Genetic Engineering Laboratory, Las Cruces, NM, p. 19.

45. Hansen, E.E., J.F. Hubstenberger, and G.C. Phillips. 1993. Regeneration of cell

suspension-derived protoplasts of Allium cepa. In Vitro Cell. Devel. Biol. 29A:62A.

46. Cheng, M., D.C.H. Hsi, and G.C. Phillips. 1993. Genetic transformation of valencia-type peanut via Agrobacterium tumefaciens. American Peanut Research and Education Society Annual Meeting, July 13-16, 1993, Huntsville, AL.

47. Cheng, M., D.C.H. Hsi, and G.C. Phillips. 1993. Transgenic plants of valencia-type

peanut expressing a 15 kD zein gene via Agrobacterium-mediated transformation. Agron. Abstr. 1993:173-174.

48. Garnenez, P.S., J.F. Hubstenberger, J.R. Barrow, and G.C. Phillips. 1993. Fungal-root

interactions of Atriplex canescens and Escobaria sneedii. 1993 American Indian Student Research Symposium, August 12-13, 1993, Bozeman, MT.

49. Francis, M., A. Dharma, P. Donaldson, G.C. Phillips, and G.D. Kuehn. 1993. Characterization of the expression of the plant gene for polyamine oxidase in a recombinant bacterial host. MARC-MBRS Symposium, New Mexico State University, October 8, 1993, Las Cruces, NM.

50. Kuehn, G.D., A. Dharma, S. Bagga, M. Francis, and G.C. Phillips. 1994. Cloning, expression, and characterization of the gene for polyamine oxidase from Medicago sativa L. Annual Meeting of the American Society of Plant Physiologists, July 1994, Portland, OR.

51. Phillips, G.C., T.A. Wheeler, and E.B. Peffley. 1994. A system of direct gene transfer

into monocots for disease resistance. Ninth Annual Symp. Southwest Consortium on Plant Genetics and Water Resources. Plant Genetic Engineering Laboratory, Las Cruces, NM.

52. Saavedra, R., G.D. Kuehn, and G.C. Phillips. 1995. Selection for resistance to inhibitors

of polyamine biosynthetic enzymes and for adaptation to high temperatures in cotton cell cultures. 1995 Congress on In Vitro Biology, May 1995, Denver, CO. In Vitro 31(3:II):54A, Abstr. P-1021.

53. Reyes, I., J.F. Hubstenberger, and G.C. Phillips. 1995. Antiauxin effects on

30

morphogenesis in cultures of the endangered cactus Aztekium ritteri. 1995 Congress on In Vitro Biology, May 1995, Denver, CO. In Vitro 31(3:II):52A, Abstr. P-1015.

54. Bagga, S., J. Rochford, R. Saavedra, P. Donaldson, T. Croughan, G.D. Kuehn, and G.C.

Phillips. 1995. Plants exposed to different abiotic stresses exhibit similar pathways for the biosynthesis of polyamines. Annual Meeting of the American Society of Plant Physiologists, July-August 1995, Charlotte, NC. Plant Physiol. (Suppl.) 108:25.

55. Songstad, D.D., S.R. Betz, G.C. Phillips, G.D. Kuehn, S. Bagga, and E. Koc. 1995. Use of uncommon polyamines in stable transformation of maize. Annual Meeting of the Crop Science Society of America/American Society of Agronomy, October 29 - November 3, 1995, St. Louis, MO. Agron. Abstr. 1995:

56. Koc, E., N. Dong, J.Y. Gardner, A. Dharma, G.C. Phillips, and G.D. Kuehn. 1995.

Isolation and expression of the gene for polyamine oxidase from Medicago sativa L. and Avena sativa L. Annual Meeting of the American Society of Biochemistry and Molecular Biology, May 21-25, 1995, San Francisco, CA.

57. Peffley, E.B., M.A. Hart, T.A. Wheeler, A. El-Sharif, N. Dong, and G.C. Phillips. 1995.

Progress towards transformation of onion, Allium cepa, via particle bombardment. Tenth Annual Symp. Southwest Consortium on Plant Genetics and Water Resources, September 8-10. Plant Genetic Engineering Laboratory, Las Cruces, NM, p. 22.

58. Reyes, I., J.F. Hubstenberger, and G.C. Phillips. 1995. Auxin antagonists enhance in

vitro morphogenetic response of the endangered Mexican cactus Aztekium ritteri. VII National Congress on Plant Biochemistry and Molecular Biology, November 5-9. Cocoyoc, Mexico, p.201.

59. Avila, E., B. Salim, G.C. Phillips, and M. Varagona. 1995. Nuclear localization of the

C1 protein in maize. 1995 NIGMS Minorities Program Symp., October 11-15. Washington, DC.

60. Bagga, S., S. Temple, C. Sengupta-Gopalan, J.D. Kemp, and G.C. Phillips. 1995.

Agrobacterium-mediated transformation of forage and grain legumes to improve protein quality. Second Internat. Plant Tissue Culture Conf., December 10-12, 1995. Dhaka University, Dhaka, Bangladesh, p. 33.

61. Peffley, E.B., M. Hart, Z. Xiang, A. El-Sharif, N. Dong, and G.C. Phillips. 1996.

Transient expression of GUS in onion transformants. Amer. Soc. Hort. Sci. Southern Region Annual Meeting, February 4-8. Greensboro, NC.

62. El-Sharif, A., N. Dong, G.C. Phillips, E.B. Peffley, M.A. Hart, and T.A. Wheeler. 1996.

Long-term expression of GUS in putatively transformed cells of onion, Allium cepa and A. fistulosum, using particle bombardment. 1996 World Congress on In Vitro Biology, June 22-27. San Francisco, CA. In Vitro Cell. Devel. Biol. 32:102A.

63. Thorpe, T.A., and G.C. Phillips. 1996. Publishing in the SIVB journal In Vitro Cellular

and Developmental Biology - Plant. 1996 World Congress on In Vitro Biology, June 22-27.

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San Francisco, CA. In Vitro Cell. Devel. Biol. 32:31A. 64. Xiang, Z., M. Hart, A. El-Sharif, N. Dong, G.C. Phillips, and E.B. Peffley. 1996.

Development of a direct gene transfer system for onion, Allium cepa and A. fistulosum, using particle bombardment. Eleventh Annual Symp. Southwest Consortium on Plant Genetics and Water Resources, August 9-11, Lubbock, TX. Plant Genetic Engineering Laboratory, Las Cruces, NM.

65. Dong, N., J. Hubstenberger, and G.C. Phillips. 1997. Apparent transformation of Allium

fistulosum callus and suspension cultures using Agrobacterium tumefaciens. 1997 Congress on In Vitro Biology, June 14-18. Washington, DC. In Vitro Cell. Devel. Biol. 33:71A.

66. Phillips, G., M. Mendoza, D. Bustamante, M. O'Connell, and E. Burlbaw. 1997. Single-

point access to biotechnology information and analysis tools via the world wide web. 1997 Congress on In Vitro Biology, June 14-18. Washington, DC. In Vitro Cell. Devel. Biol. 33:23A.

67. El-Sharif, A. and G.C. Phillips. 1997. Apparent transformation of onion by

bombardment of zygotic embryos. 1997 Congress on In Vitro Biology, June 14-18. Washington, DC. In Vitro Cell. Devel. Biol. 33:50A.

68. Phillips, G., M. Mendoza, D. Bustamante, M. O'Connell, and E. Burlbaw. 1997. Web-

based single-point access to biotechnology information and analysis tools. Annual Meeting of the American Society for Horticultural Science, July 22-26. Salt Lake City, UT.

69. Jayashankar, S., S. Bagga, and G.C. Phillips. 1997. Pepper (Capsicum annuum L.)

transformation using Agrobacterium rhizogenes. Annual Meeting of the American Society for Horticultural Science, July 23-27, 1997, Salt Lake City, UT. HortScience 32:454

70. Gardner, J.Y., E. Koc, N. Dong, A. Dharma, S. Bagga, G.C. Phillips, and G.D. Kuehn.

1997. Isolation, cloning, and expression of the gene for polyamine oxidase from Avena sativa L. (oat). Annual Meeting of the American Society of Plant Physiologists, August 2-6, 1997, Vancouver, BC. Plant Physiol. (Suppl.) 114(3):177, Abstr. 870.

71. Dong, N., J.Y. Gardner, G.D. Kuehn, and G.C. Phillips. 1998. Transgenic tobacco

plants express an oat cDNA coding for polyamine oxidase. 1998 Congress on In Vitro Biology, May 30 - June 4. Las Vegas, NV. In Vitro Cell. Devel. Biol. 34:66A.

72. Lucero, M.E., J. Lopez, J. Hubstenberger, W. Mueller, G.C. Phillips, and M.A. O’Connell. 1999. Nitroreductase activity in plant cell and tissue cultures. Annual Meeting of the American Society of Plant Physiologists, July 24-28, 1999, Baltimore, MD.

73. Phillips, G.C., L. Valera-Montero, Z. Fan, S. Jayashankar, J.F. Hubstenberger, and D.D. Watkins. 2000. Chile improvement through biotechnology: In vitro plant regeneration and genetic transformation. New Mexico Chile Pepper Institute Chile Conference 2000, February 8, 2000, Las Cruces, NM.

74. Valera-Montero, L. and G.C. Phillips. 2001. Plant regeneration from long-term callus cultures of Capsicum. 2001 Congress on In Vitro Biology, June 16 - 20. St. Louis, MO. In

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Vitro Cell. Devel. Biol. 38:379 (P-3034).

75. Valera-Montero, L. and G.C. Phillips. 2002. Comparison of Capsicum baccatum and C. annuum for stable transformation using Agrobacterium rhizogenes. 2002 Congress on In Vitro Biology and 10th IAPTC&B Congress, June 23 - 28. Orlando, FL. In Vitro Cell. Devel. Biol. 38:139-A (P-1719). 76. Valera-Montero, L. and G.C. Phillips. 2003. Stable transformation of Capsicum annuum and C. baccatum explants inoculated with A. rhizogenes and A. tumefaciens. 2003 Congress on In Vitro Biology, May 31 - June 4. Portland, OR. In Vitro Cell. Devel. Biol. 39: (P-1009).

77. Phillips, G.C., J.L. Farris, C.R. Shumway, and J.L. Bouldin. 2004. The confluence of agricultural production and environmental impacts in the Mid-South Region: Need for coordinated research programs. Mid-South Regional Chapter, Society of Environmental Toxicology and Chemistry, May 26 - 28. Oxford, MS. Meeting Program and Abstract Book, p. 34. 78. Phillips, G.C. and J. Ranch. 2008. Interviewing basics and the differences between academia vs. business. Education symposia, 2008 World Congress on In Vitro Biology, Society for In Vitro Biology, June 14-18. Tucson, AZ. In Vitro Cell. Devel. Biol. – Animal 44:S15 (E-6).

Brett J. Savary Research Associate Professor of Protein Chemistry Arkansas Bioscience Institute and College of Agriculture Arkansas State University - Jonesboro PO Box 639 State University, AR 72467

Phone 870-680-4792 Fax 870-970-2026 Email [email protected] Web http://abi.astate.edu/people/?id=83

Research Interests My research program in the Arkansas Bioscience Institute focuses on the analytical biochemistry and protein chemistry of carbohydrate-modifying enzymes from plant and microbial sources and their application to modifying structural polysaccharide components present in agricultural processing residues. My laboratory conducts research to 1) purify and characterize enzymes active towards plant cell wall polysaccharides, 2) develop analytical tools to separate, detect, and measure enzyme activities and their substrate action patterns, and 3) apply well-defined monocomponent enzymes to understand structure-functional property relationships of cell wall polysaccharides. Application of this research involves multidisciplinary cooperation with carbohydrate, food, and polymer chemists to characterize chemical, physical, and functional properties of enzyme-modified polysaccharides. Our research accomplishments provide a foundation of fundamental knowledge to enable the rational design of valuable new polysaccharide-based bioproducts with improved performance and greater functionality. Education: Ph.D., Plant Physiology, Pennsylvania State University M.S., Botany, University of Tennessee B.S., Biology, Iowa State University Professional Experience Research Associate Professor, Arkansas State University, 2006 to present Research Plant Physiologist, USDA Agricultural Research Service, 1998 to 2006 Postdoctoral Research Associate, USDA Agricultural Research Service, 1995 to 1998 Graduate Research Assistant, Penn State University, 1990 to 1995 Research Associate, University of Tennessee, 1987 to 1990 Graduate Research Assistant, University of Tennessee, 1984 to 1986 Professional Associations American Chemical Society American Society of Plant Biologists America Society for Mass Spectrometry Institute of Food Technologists Gamma Sigma Delta Agriculture Honor Society Sigma Xi Scientific Research Society Current Funding and Agreements Arkansas Biosciences Institute, Protein Chemistry and Enzyme Systems Useful in Health and Agriculture; PI, $200,000 (October 2006 through June 30, 2009). USDA-CSREES NRI, Mapping pectin nano-structure and functionality and modeling enzyme action and properties; co-PI, $96,000 to lab (October 2008 to September 2010). USDOE Mid-South/Southeast Biofuels Consortium, Biochemical technologies for generating valuable co-products from biofuel production; co-PI, $157,000 (Sept. 1 2008 to Aug. 31, 2009). USDA-ARS, Wyndmoor, Specific Cooperative Agreement: Polysaccharide-modifying enzymes from citrus and sugar beet cell walls; PI, instrument (Oct. 2007 to Sept. 2009).


http://abi.astate.edu/people/?id=83

Invited Talks for Scientific Conferences • Prospecting for polysaccharide modifying enzymes useful for generating biobased products from plant cell walls. Presented at BIO Pacific Rim Summit on Industrial Biotechnology and Biofuels: Biorefinery Co-Products (panel co-organizer and chair), Vancouver, CA, 2008. • New technologies for identifying pectin modifying enzymes. Presented at Pacifichem 2005, Program #221: Pectin Chemistry - Relationship to Structure and Function, Honolulu, HI, 2005. • Mass spectrometry peptide profiling for identification of Valencia orange pectin methylesterase isoforms. Presented at 229th National Meeting of the American Chemical Society, Symposium on Pectins: Health and Agrichemical Applications (CELL Div.), San Diego, CA 2005. • Sustainable technologies and valuable new polysaccharide-based products from sugar beet pulp. Presented at Sugar Processing Research Institute Conference, Atlanta, GA, 2004. • Characterization of the salt-independent pectin methylesterase isolated from orange peel and its use for modifying pectin structure and related functional properties. Presented at the international symposium: Pectins and Pectinases, Rotterdam, The Netherlands, 2001. • Enzymology and technology of orange pectin methylesterase. Presented at Rocky Mountain Plant Biotechnology and Molecular Biology Symposium, Colorado State Univ., Ft. Collins, 2001. • Purification and properties of plant pectin methylesterases and their use in studying pectin structure-functional property relationships. Presented at American Chemical Society 220th National Meeting, Symposium Biochemistry of Polysaccharides (CARB Div.), Washington, 2000. Peer-Reviewed Research Publications (10 most recent) • Yoo, S.-H., B.-H. Lee, B.J Savary, A.T. Hotchkiss. Characteristics of PME-deesterified pectin gels produced in the presence of monovalent ionic salts. J. Agric. Food Chem. (Submitted 2008.) • Savary, B.J., Prasanna V., A. Nuñez, R.G. Cameron. Identification of thermolabile pectin methylesterases isolated from sweet orange fruit by mass spectrometry profiling. J. Agric. Food Chem. (Submitted 2008.) • Prasanna V., B.J. Savary, R.G. Cameron, A. Nuñez, and M.G. Bausher. Isolation, characterization, and cloning of a polygalacturonase-inhibitor protein from sweet orange fruit tissues (Citrus sinensis L.). (Prepared for submission to Biochemical Journal.) • Prasanna V., Savary, B.J., D. Anandan, A.C. Smigocki, A. Nuñez. Prospecting the sugar beet root secretome for polysaccharideactive enzymes. (In preparation for J. Sugar Beet Research.) • Savary, B.J., R.G. Cameron, G.A. Luzio, Prasanna V., A. Nuñez, and T.G. McCollum. Thermally-tolerant pectin methylesterase. U.S. patent application 11/986,187, filed November 20, 2007. (Peer-reviewed manuscript in preparation for J. Agric. Food Chem. 2008.) • Cameron, R.G., B.J. Savary, A.T. Hotchkiss, M.L. Fishman, 2005. Isolation, characterization and pectin modifying properties of a thermally tolerant pectin methylesterase from Citrus sinensis var. Valencia. J. Agric. Food Chem. 53:2255-2260. • Savary, B.J., K.B. Hicks, M.L. Fishman, A.T. Hotchkiss, L.-S Liu, 2004. Sustainable technologies and valuable new polysaccharide-based products from sugar beet pulp. Proceedings 2004 Sugar Processing Research Institute Conference, pp. 80-86. • Savary, B.J., B.R. Newswanger, A. Nuñez, 2004. Application of a new GC-MS method for determining ester contents following base- and enzyme-hydrolysis of sugar beet pulp and pectin. Proceedings 2004 Sugar Processing Research Institute Conference, pp. 449-453. • Sharma, N., S.-W. Park, R. Vepachedu, L. Barbieri, M. Ciani, F. Stirpe, B.J. Savary, J.M. Vivanco, 2004. Isolation and characterization of an RIP-like protein from Nicotiana tabacum with dual enzymatic activity. Plant Physiology 134:171-181. • Savary, B.J., and A. Nuñez, 2003. Gas chromatography-mass spectrometry determination of methanol and acetic acid content of pectin using headspace sampling with solid-phase microextraction and stable isotope dilution. J. Chrom. A. 1017:151-159.

M.Srivatsan Last Updated: 07/12/08

Malathi Srivatsan

Department of Biological Sciences/Arkansas Bioscience Institute Arkansas State University

Jonesboro, AR 72401, USA (Phone) 870-972-3167; (Fax) 870-972-2168; (Email) [email protected]

Education Bioinformatics : Stanford University, CA , Proteomics, Genomics and Certification Computational Molecular biology

Ph.D Department of Cell biology and Human Anatomy (Thesis on "An experimental

study of the neuromuscular apparatus after immobilization of a limb in young and old"), Mentor Dr. N. H. Keswani at All India Institute of Medical Sciences, New Delhi, India

M.S. Human Anatomy (major), Physiology and Biochemistry (minor) from Jawaharlal

Institute of Postgraduate Medical Education and Research, Pondicherry, India B.S Zoology (major), Botany and Chemistry (minor)from Madras University, India. Professional Experience 2008-Present Associate Professor at Dept. of Biological Sciences, Arkansas State

University , Jonesboro, AR 2003-Present Assistant Professor at Dept. of Biological Sciences, Arkansas State

University , Jonesboro, AR 2003-Present Adjunct Faculty at Dept. of Neurobiology & Developmental Sciences,

U.A.M.S. Little Rock. AR 2006-Present Adjunct Faculty, School of Bioengineering, University of Arkansas,

Fayetteville, AR 1997-2003 Research Assistant Professor at Dept. of Physiology, Univ. of Kentucky

College of Medicine, Lexington, Kentucky

1994-1997 Research Associate at Dept. of Physiology, Univ. of Kentucky College of Medicine, Lexington, Kentucky

1989-1993 Postdoctoral fellow in project funded by National Institute of Aging on “neuron survival in the aging nervous system” Mentor Dr. Bertram Peretz at Department of Physiology, Univ. of KY College of Medicine

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1987-1988 Adjunct Faculty (Anatomy), School of Medicine, University of Minnesota 1986 -1987 Teaching Specialist (Anatomy), Robert Wood Johnson School of

Medicine, University of Medicine and Dentistry, Piscataway, New Jersey 1985-1986 Adjunct Faculty (Embryology), Department of Biology and Natural

Sciences, Dowling College, Oakdale, New York 1982-1984 Reader (Associate Professor), Dept. of Anatomy, Kasturba Medical

College, Manipal, India 1980- 1982 Senior Lecturer (Assistant Professor), Dept. of Anatomy, Medical college,

University of Calabar, Calabar, Nigeria

1978 – 1980 Reader, Dept. of Anatomy, Mahatma Gandhi Institute of Medical Sciences, Sewagram, India 1976-1978 Lecturer, L.L.R.M. Medical College, Meerut, India Honors and Awards 2007 Chosen to mentor graduate students by the Diversity committee of Society

for Neuroscience 2006 Certificate of Excellence in Mentoring undergraduate research: from Faculty for

Undergraduate Neuroscience, Society for Neuroscience 2004 & 2005 Certificate of appreciation for Mentoring High School Teachers in Neuroscience Research from Arkansas STRIVE 2000 Scholarship from Cold Spring Harbor Laboratory to attend an international

workshop for young investigators on ‘Molecular Mechanisms of Human Neurological Diseases’.

1997 Travel Award from International Society for Neurochemistry 1995 Scholarship from NIH (NIA) to attend international workshop on biology of aging held at San Antanio, Texas

1990 - 1994 Postdoctoral fellowship from NIH/NIA 1993 Fellowship from training grant, NIH/NIMH 1982 Best teacher award in basic medical sciences at Kasturba Medical College,

Manipal, India 1977 Graduate students representative to Institute senate at A.I.I.M.S. India


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1974-1977 Graduate research fellowship from Director General of Health Services, India 1966-1969 National Merit Scholarship, Govt. of India

Research Interests

(1) Applications of wireless and nanotechnology to develop neuro-sensors and neuro-stimulators

(2) Environmental neurotoxicity (3) Plant –derived antioxidants for neuroprotection in oxidative stress

(4) Cholinergic mechanisms in neuron regeneration

(5) Nicotine and the developing autonomic neurons

(6) Application of Bioinformatics in neuroscience research

Research Support Extramural Pending

Co-PI on R21 (NIH/NINDS) Peanut hairy root derived antioxidants for neuroprotection, Direct cost of the grant, $250,000

Current 2008-2010 Co-PI on NSF EPSCoR grant proposal to develop infrastructure for Wireless,

Nano, Bio, Neuro sensors. Direct cost for neurosensor research $ 748,000, Direct cost of the total grant, $4,500,000

2006-2009 P.I. on NIH/NIDA R15 “Nicotine and development of autonomic neurons”.

Direct cost, $150,000. 2005-2010 P.I. on NIH/NCRR INBRE“Cholinergic mechanisms in neuroregeneration”. Direct

cost, $362,000. Completed 2004- 2005 P.I. on NIH/NCRR BRIN “Cholinergic mechanisms in neuroregeneration”.

Direct Cost, $48,000 2004-2005 PI on ABI/AR “Effects of nicotine on developing autonomic neurons” Direct cost $150,000.


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2001-2003 P.I. on grant from Kentucky Spinal cord and head injury research board to study neuroregeneration in rat dorsal root ganglion neurons. Direct cost $ 171,154. 1997– 2004 P.I. on NIH/NINDS R29 to investigate acetylcholinesterase’s novel role in neuroregeneration. Direct cost $350,000. 1999 - 2000 P.I. on NIH/NIA Pilot Grant from Alzheimer’s Disease Research Center

(Sanders Brown Center for Aging) University of Kentucky to investigate acetylcholinesterase and amyloidosis . Direct cost $ 20,000.

Intramural 2006-2007 Faculty development award, P.I. on nano material and neurotoxicity. Direct cost, $4,500. 2005 Summer ABI/ASU P.I. Faculty research award to study “nicotine and developing sympathetic neurons”. Direct cost, $12,200. 2005 Summer ABI/ASU P.I. Faculty research award to develop spinal cord and brain injury impactor. Direct cost, $11,800. 2004-2005 ABI/ASU P.I. on grant proposal to study the nicotinic effects on neuronal development and growth. Direct cost $140,156. 2004-2005 ABI/ASU Co-PI on grant proposal on “Assessing the benefits of

genetically modified crops: Effects of agricultural practices on small mammal populations”. Direct cost, $75,000.

2003-2004 ASU Faculty award P.I. on “Effects of organophosphate pesticide on

aquatic organisms”. Direct cost, $4,000.

2003 P.I. Pilot grant funding from U.K.College of Medicine for microarray analysis of gene expression profiles in rat sensory neurons exposed to acetylcholinesterase and its pesticide inhibitors. Direct cost, $5,000.

1980 – 1982 PI on Senate Research Committee Grant - Calabar, Nigeria - to investigate age-related changes at the neuromuscular junctions- $2,000 / year.

Invited Presentations (National and International) 2008 “Nano materials for Differentiation, Growth and repair in the Nervous system” at

Fifth International conference on Smart materials, sensors and systems, Bangalore, India

2008 “Survival and regeneration of neurons:Role of trophic mechanisms to counter neurodegeneration” seminar presented at Department of Bioengineering, University of Arkansas at Fayetteville, Arkansas


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2007 “ Effects of nicotine on neuro-immune interactions in sympathetic neurons of rat” at Cellular and Molecular Mechanisms of Drugs of Addiction at International Society of Neurochemistry, Merida, Mexico

2006 “Nicotine alters nicotinic receptor levels in a sub unit-specific manner in sympathetic neurons of rat” Symposium on Venice, Italy.

2003 “Novel neurotrophic functions of acetylcholinesterase” research seminar at Dept of

Biological Sciences, Arkansas State University, Jonesboro, AR 2002 “Neural and circulating acetylcholinesterase of Aplysia”. Biocatalysis -

International conference on Chemical Enzymology at Moscow State University, Moscow, Russia.

2000 “Effects of organophosphates on survival in dorsal root ganglion neurons of rat.” International symposium on applications of enzymes in chemical and biological defense at Orlando, Florida.

1998 “Effects of organophosphates on cholinesterase activity and neurite regeneration

in Aplysia”. At Third international meeting on esterases reacting with organophosphorus compounds at Dubrovnik, Croatia.

1995 “Circulating acetylcholinesterase promotes neurite growth in adult

neurons of Aplysia”. At Satellite symposium on "Novel functions of cholinesterases in development and disease" at the annual meeting of Society for Neuroscience, San Diego, CA.

1994 Neurotrophic function of circulating acetylcholinesterase in Aplysia. At Fifth international meeting on cholinesterases at Madras, India

Peer Reviewer Grants: 2003 Reviewer for Alzheimer’s Association Research Grants Program 2001 Reviewer for Cooperative Grants Program of the U.S. Civilian Research

and Development funded by NSF and US State Department 1980 - 1982 Reviewer for Senate Research Committee Grants, University of

Calabar, Nigeria

Journal Manuscripts:

1995 – present Reviewer for Neurobiology of Aging Neuroscience Letters Journal of Comparative Physiology Comparative Physiology and Biochemistry Journal of Neurochemistry Archives in Biochemistry and Biophysics


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Software and book chapters: 2004 Hole’s Human Anatomy and Physiology, McGraw Hill 2005 Anatomy & Physiology Revealed, McGraw Hill Research Mentor 2007-present Graduate Students (Ph.D., Molecular Biosciences) Mr. Chandrajit

Chowdhuri and Mr. Seth Scirmer 2004 - 2008 Postdoctoral Fellow, Dr.B.M.Prabhu

2005 Postdoctoral Fellow, Dr. Meena Arvindhakshan

2004-2005 Summer research training for High School teachers, Ms. Theresa Fuller and Ms Amanda Herring through Arkansas STRIVE funding

1982-1984 Two postgraduate students of medicine in their research and thesis for

their Master’s degree in neurobiology Name Current Status Dr. M.R. Belsare Professor of Anatomy, PRDM Medical

College, India Dr. K.M. Kulkarni Professor of Anatomy, Ramaiah Medical

College, Bangalore, India

1997-2008 Undergraduates mentored in Research

Name Current Status Rholandas Hill In Training Tracy Bianco In Training Jonathan Treece Medical Student Justin Yancey M.D.,Ph.D. student Swati Mishra In Training Trevor Wisdom In Training Eric Duncan Graduate student (NSF/RISE) Brett Williams Graduating senior (NSF/RISE) Anthony Anston Medical Student Ezekiel Shotts Medical Student Carrie Cavanaugh Graduate Student Lauren Momsen Research Associate Mark MgGinnes Medical Student Chad M. Fite Resident (Pediatrics) Tina Shrestha Graduate Student Shawna N. Billiter Clinical Psychologist Louetta Hurst Nursing Student Andrew Matiso Resident in Anesthesiology Chris Adley Resident in Pediatrics


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Thesis Committees 2007-Present Graduate dissertation of Chandrajit Choudhuri and Seth Schirmer 2007-Present Graduate dissertation of Maria Isabel Ferrand Malatesta 2006-Present Graduate dissertation of Kiran Artre, University of Arkansas, Fayetteville 2005-2008 Graduate dissertation of Alejandra Ratti, Jane Anfinson 2004-Present Graduate dissertation of Katherine McKeon 2005-2006 Undergraduate Honors thesis of Akash Shah and Hemab Mishra 1980-1982 Graduate dissertation of Dr. M.R. Belsare, Dr. K.M. Kulkarni Membership in Professional Societies Society for Neuroscience Women in Neuroscience American Association for the Advancement of Science International Society of Neurochemistry International Society for Computational Biology International Drug Abuse Research Society Society of Environmental Toxicology and Chemistry Faculty for Undergraduate Neuroscience Mid-South Chapter of Society of Environmental Toxicology and Chemistry Arkansas Academy of Science Mid-South Society of Bioinformatics Society for Neuroscience – Arkansas Offices held in Professional Organizations Society for Neuroscience - Officer in charge of Brain bee for North East Arkansas Teaching Experience 2007-present BIOL 4333/5333 Cell Signaling (ASU) 2003-2006 ZOOL 2001, 2011 Human Anatomy and Physiology I & II, Lecture & Lab

(ASU) 2004-present ZOOL 3203, ZOOL 3201, Animal Physiology (Lecture & lab), (ASU) 2006-present BIOL / CHEM 4243 Pharmacology (Neuropharmacology – Lecture) (ASU) 2006-present BIOL-4393-003 Special Problems, Research in Neurobiology (ASU)

(Independent Study Course)

2005-present ZOOL-5163 / 4163 Mammalian Neurobiology (Lecture & lab) (ASU) 2005-present ZOOL 6XX3 Advanced Cellular and Molecular Neurobiology (ASU)


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2005 BIOL-4271-003 Research in neurochemistry (Independent Study Course) (ASU) 2004 Spring ZOOL-H-3203-001 Honors Animal Physiology (ASU) 1994 - 2000 PGY 602 (Neurophysiology section) to graduate students (Ph.D.) at Department

of Physiology, College of Medicine, University of Kentucky

1994 Bio 103 Introductory biology including Neurobiology at Lexington Community College, University of Kentucky

1992-1994 PGY 502 Cell and membrane physiology to graduate students at Univ. of

Kentucky 1987 Masters course in Neuroanatomy to Nurse Anesthetists at Univ. of Minnesota 1986 – 1987 NSCI 6000 Gross and Developmental Anatomy (embryology) to Graduate Students of Medicine at Department of Anatomy and Neuroscience at Robert Wood Johnson Medical School, UMDNJ, NJ 1985 - 1986 Bio 351, Developmental Biology (embryology) to students in Biology Major,

Department of Biology and Natural Sciences, Dowling College, Oakdale, NY 1982 - 1984 Director of Histology, Taught Histology and Neuroanatomy to Medical, Dental and Pharmacy students at Dept. of Anatomy, Kasturba Medical College, Manipal, India 1980 – 1982 Neuroscience, Histology and Histochemistry to Graduate Students of Medicine and Undergraduate students in Radiology and Physiotherapy at Dept. of Anatomy, Medical college, University of Calabar, Nigeria 1978 -1980 Gross Anatomy and Histology to Graduate Students of Medicine at Mahatma Gandhi Institute of Medical Sciences, Sewagram, India 1976-1978 Gross Anatomy and Histology to Graduate Students of Medicine at L.L.R.M. Medical College, Meerut, India New Courses Developed 2006 Basics of Neuroscience for Bioengineering 2006 Pharmacology (neuropharmacology part) 2004 Cellular and Molecular Neurobiology 2004 Cell signaling 1999 Advanced Neurophysiology (team taught course) 1981 Integrated neuroscience (team taught course by faculty from Anatomy, Physiology, Biochemistry, Pathology, Neurology and Neurosurgery departments)


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Service

Department A. Departmental Committees 1. Electronic Journal (2004 - Present) 2. Strategic committee (2004 & 2005) 3. Curriculum Committee (2005- Present) 4. Committee on Ecotox facility (2005) 5. Pre Professional interview committee (2005- Present) 6. Departmental website committee (2005-2006) 7. Scholarship committee – pre professional (2004 & 2005) 8. Minority Committee / Chair (2004 – Present) 9. Graduate students / Teaching assistants task force (2003-2004)

10 In-charge of purchase, maintenance and training of users of shared equipment facility at Dept. of Physiology, University of Kentucky (1996-2003) 11.Faculty search committee, Department of Physiology, Univ. of KY (1998-1999) 12. Supervisor in-charge of delegation of duties and performance evaluation of lecturers, instructors and technical staff in medical colleges in India (1978-1982) 13. Director of graduate studies (master’s degree), Director of Histology, Kasturba Medical college, Manipal, India (1982) University 1.Research Committee (2006-Present)

2. Strategic planning committee on graduate education and research (2003-2004) 3. ABI Protein Chemist Faculty recruitment committee (2005-2006) 4. ABI Microscope facility management committee (2005-Present) 5.Member, Committee for integrated neuroscience curriculum development, Calabar Medical College, University of Calabar, Nigeria (1980-1982) 2006. Attended NCSE organized fall capitol hill meeting and communicated the importance of increased funding to ASU through NSF to the elected representatives. 2005 Attended Minority role model conference to learn and network for increasing enrollment of minorities at ASU Students Academic Clubs Faculty advisor for Medical Arts Club (2005-Present) Faculty Advisor for ASU – Society for Neuroscience Community


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2005-present Grand Prize Judge for Craighead County Science Fair

2005-present Along with Dr. Amy Pearce conducted Brain awareness day at public library for Jonesboro public. This was well received by the public with requests for several repeat performances 2005 Judged graduate student presentations for best presentation award in Biological sciences

at Annual Meeting of Arkansas Academy of Sciences, 2005, Hendrix college, Arkansas

2005 Chaired a session during undergraduate scholars day, ASU, 2005 2005 Participated in Minority access annual conference at Los Vegas, and moderated a session

on recruitment and retention of minority students 2004 Trained two high school students in neuroscience research during summer of 2004 under

Science, Society, Leadership Program

2004 Category Judge for Craighead County Science Fair 2003 As a member of the ASU environmental science forum, “ Second Nature”, have

encouraged student participants towards organizing events to promote community awareness of environment

1997 Judge for International science fair organized by Intel and GE 1993 - 1999 Judge for Science fair, Fayette county schools, KY 1994-2003 Speaker on neuroscience and research to school children at Fayette county, KY during brain awareness week Publications (non-peer reviewed) M. Srivatsan (2005) Researchers investigating enzymes to treat spinal cord injury: in Jonesboro Sun, 10/08/2005 M.Srivatsan (2006) Scientists find bad experiences may cause 'scars' in brain tissue: in Jonesboro Sun, 04/01/2006 J.Treece and M.Srivatsan (2007) ASU researchers studying effects of nicotine in cigarette smoking in newborn rats: in Jonesboro Sun, 06/15/2007 Publications (Peer Reviewed) Srivatsan, M. (2008) Additive effects of acetylcholinesterase and collagen on neurite growth in DRG Neurons of rat. Brain Research (manuscript in preparation) Eric Duncan, Jonathan Treece and Malathi Srivatsan (2008) The expression of brain cholinesterases change with age in fat head minnow (Pimephales promelas) Environmental toxicology and chemistry (submitted)


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Jining Xie, Linfeng Chen, Vijay K Varadan, Justin Yancey and Malathi Srivatsan (2008) The effects of functional magnetic nanotubes with incorporated nerve growth factor in neuronal differentiation of PC12 cells Nanotechnology 19 105101-105108 Srivatsan, M. (2006) An analysis of acetylcholinesterase sequence for predicting mechanisms of its non-catalytic actions. Bioinformation, 1(8): 281-284

M. Srivatsan, J. Treece and E.E. Shotts (2006) : Nicotine alters nicotinic receptor subunit levels differently in developing mammalian sympathetic neurons. Ann N.Y.Acad. Sci. 1074: 505-513

Jining Xie, Linfeng Chen, Kiran R Aatre, M Srivatsan and V K Varadan (2006) Somatosensory neurons grown on functionalized carbon nanotube mats. Smart Materials and Structures, 15: N85-88.

Chad Fite, Malathi Srivatsan (2003) Neural and circulating cholinesterases of the marine mollusk Aplysia californica. Chem. Bull. Vol. 44: 62 -65

Srivatsan, M. (2001) Effects of organophosphates on survival in dorsal root ganglion neurons of rat in Enzymes, 2001 (proceedings of international symposium on applications of enzymes in chemical and biological defense). Srivatsan, M. (1999) Organophosphates inhibit acetylcholinesterase and impair neurite growth of cholinergic neurons in Aplysia. Chemico-Biological Interactions, 119-120: 371-378. Srivatsan, M. and Peretz, B. (1997) Acetylcholinesterase promotes regeneration of neurites in Cultured adult neurons. Neuroscience, 77:921-931. Srivatsan, M. and Peretz, B. (1996) Effects of acetylcholinesterase inhibition on behavior is age-dependent in freely moving Aplysia . Behav. Brain Res. 77: 115-124. Peretz, B. and Srivatsan, M. (1996) Chronic stimulation increases acetylcholinesterase in old Aplysia Behav. Brain Res. 80:203-210. Srivatsan, M. and Peretz, B. (1995) Neurotrophic function of circulating acetylcholinesterase in Aplysia. pp 449-450, In " Enzymes of the Cholinesterase family" Eds. A.S. Balasubramanyan, B.P. Doctor, P. Taylor and D.M. Quinn, Plenum Publishing CO., New York, NY. Srivatsan, M., Peretz, B., Hallahan, B. and Talwalker, R. (1992) Acetylcholinesterase and other hemolymph proteins change with age in Aplysia. J. Comp. Physiol. B. 162: 29-37. Peretz B. and Srivatsan, M. (1992) Differences in aging in two neural pathways: Proposed explanations from the nervous system of Aplysia . Expr. Geront. 27:83-97. Kindy, M.S., Srivatsan, M. and Peretz, B. (1991) Age-related differential expression of

http://www.iop.org/EJ/search_author?query2=Malathi%20Srivatsan&searchfield2=authors&journaltype=all&datetype=all&sort=date_cover&submit=1


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neuropeptide mRNAS in Aplysia. Neuroreport 2:465-468. Malathi, S. and Batmanabane, M. (1988) Effects of immobilization of a limb on the maturation of a peripheral nerve in kittens. Acta Anat. 132(3):191-6. Malathi, S. and and Batmanabane, M. (1986) Influence of immobilization of limbs in kittens on the morphology of the developing neuromuscular junctions. Acta Morphol. Neerl. Scand., 24: 139-143. Batmanabane, M. and Malathi, S. (1985) Movements at the carpometacarpal and metacarpophalangeal joints of the hand and their effect on the dimensions of the articular ends of the metacarpal bones. Anat Rec. 1985;213(1):102-10. Batmanabane, M. and Malathi, S. (1983) Identification of human second, third, and fourth metatarsal bones. Anat Rec. 1983;207(3):509-11. Malathi, S. and and Batmanabane, M. (1983) Alteration in the Morphology of the neuromuscular junction following experimental immobilization in cats. Experientia, 39: 547- 549. Malathi, S. and Batmanabane, M. (1983) Effects of varying periods of immobilization of a limb on the morphology of a peripheral nerve. Acta Morphol, Neerl. Scand., 21: 185-198. Batmanabane, M,, Malathi, S. and Ekandem, G.J. (1982) Polymethyl methacrylate dissolved in chloroform as treatment for superficial digital injuries. Am J Surg. 1982 Nov;144(5):527. Malathi, S. (1982) Morphology of the Schwann cells and the myelinated fibers of a nerve supplying an immobilized muscle. Experientia, 38: 22-28. Malathi, S. (1981) A histochemical study of the acetylcholinesterase activity at neuromuscular junctions in the tibialis anterior and the soleus muscles of the dog. Curr. Sci., 50: 443-447. Presentations (Abstracts)

J. Treece, M.P. Badanavalu and M. Srivatsan (2007) Neuro immunomodulation by nicotine at Annual meeting of International Drug Abuse Research Society, Merida, Mexico, 2007 J. Treece, M.P. Badanavalu and M. Srivatsan (2007) Nicotine influences cytokine expression in sympathetic neurons of rat at satellite meeting on Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science, San Diego, CA M. P. Badanavalu, S. F. Ali , S.M. Hussain M. Srivatsan. Copper nanoparticles exert size-dependent toxicity on somatosensory neurons of rat at Society for Neuroscience annual meeting, San Diego, CA 2007


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Mahadevappa P. Badanavalu, Malathi Srivatsan, Ganapathy Sivakumar, Jose Condori, Fabricio Medina-Bolivar. Do Plants Hold The Promise To Protect Us from Parkinson’s Disease? “Yes”- Neuroprotective Effects Of Peanut Hairy Root Extract Against Oxidative Stress at ABI annual Symposium, Little Rock, AR 2007

M. Srivatsan (08/16/2007) “Neuro immunomodulation by nicotine” Annual meeting of International Drug Abuse Research Society, Merida, Mexico, 2007

M. P. Badanavalu, S. F. Ali , S.M. Hussain M. Srivatsan (2007) Copper nanoparticles and neurotoxicity in rats at Arkansas Chapter of Society for Neuroscience annual meeting, Little Rock, AR 2007

Jason Sinks, Mahadevappa B. Prabhu and M.Srivatsan Nano materials and neuron interaction. McNair Scholars Summer Research Symposium, Jonesboro, AR 2007

J.Yancey, J. Xie, L. Chen, V. Varadan and M.Srivatsan: Nanotubes as trophic molecule delivery system to promote differentiation of neurons. Second Nano Bio TechnologySymposium, Little Rock, AR 2007 Won the best poster presentation award among the three states

Hannigan, R. and Srivatsan, M. Environmental Studies at the graduate level: How is it defined? What kinds of standards or common threads run among different programs? Second Environmental Studies summit, Syracuse, NY 2007.

M. P. Badanavalu, S. Mishra, M. Srivatsan, L. Nopo-Olazabal, K. Brown, F. Medina-Bolivar: Extract from Hyoscyamus muticus Hairy Roots has a dose dependent effect on oxidative stress mediated cell death in PC12 Cell derived neurons. ABI annual symposium. Little Rock, AR, 2006. Jonathan Treece, Swati Mishra and Malathi Srivatsan (2006) Specific cytokines are synthesized and released by sympathetic neurons in cell culture. Soc. Neurosci. Abstr., 26: J. Treece, M. Arvindhakshan and M.Srivatsan (2006) Extracellular acetylcholinesterase is neurotrophic to somatosensory neurons of rat. NIH / NCRR IDeA Symposium. J. Treece, E.E. Shotts and M.Srivatsan (2005) Nicotine and developing autonomic neurons of mammalian nervous system Ark Acad Sci Abstr. E. Duncan, J.Treece and M.Srivatsan (2005) Exposure to environmental level of malathion is more detrimental to brain cholinesterase of adult, reproductive minnow (Pimephalus Promilas) than the young. Ar Soc Neurosci Abstr. M. Srivatsan; B.M. Prabhu; C. Cavenaugh; L. Mommsen; E.E. Shotts (2004) Nicotine influences survival and neurite growth differently in neonatal sympathetic neurons Soc.Neurosci.Abstr. 24: 2004. Srivatsan, M. (2001) Effects of organophosphates on survival in dorsal root ganglion neurons of rat. International symposium on applications of enzymes in chemical and biological defense at Orlando, Florida


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C. Fite, D.F. Speck and M.Srivatsan (1999): Circulating acetylcholinesterae of Aplysia- Purification and properties. Society for Neuroscience Abstr., 25: 450. Srivatsan, M.: (1999) Acetylcholinesterase binds to dissociated neurons of Aplysia. Society for Neuroscience Abstr., 25:740. Srivatsan, M. and Peretz, B. (1997) Neural and circulating acetylcholinesterase in Aplysia: Further characterization. Neuroci. Abstr. 23: 2017. Srivatsan, M., Fuller, L. Z., Jackson, B.A. and Peretz, B. (1995) Acetylcholinesterase modulates dopamine-stimulated cAMP accumulation in Aplysia gill. Neurosci. Abstr. 21:2069. Peretz, B., Brown, D.R. and Srivatsan, M. (1995) Neuromodulation by AChE in identified Cholinergic and non-cholinergic neurons. Neurosci. Abstr. 21: 1600. Srivatsan. M. and Peretz, B. (1994) Neurotrophic function of circulating acetylcholinesterase in Aplysia. Fifth international meeting on cholinesterases. Srivatsan,M and Peretz, B. (1993) Effects of acetylcholinesterase inhibition on behavior is age- dependent in Aplysia. Soc. Neurosci Abstr. 19: 569. Peretz, B. and Srivatsan, M. (1993) Chronic sensory stimulation has age related effects on acetylcholinesterase activity. Soc. Neurosci Abstr. 19: 569, 1993. Peretz, B., Srivatsan, M. and Hallahan, B. (1992) Acetylcholinesterase regulation in Aplysia: Effects of age and chronic sensory stimulation. Soc. Neurosci Abstr. 18: 583, 1992. Srivatsan M., Hallahan, B., Peretz, B. and Talwalker, R. (1990) Age and chronic stimulation affect hemolymph protein in Aplysia. Soc Neurosci Abstr 16:597. Dewey, M., F. Anapol and Srivatsan, M. (1985) Cytochemical observations on the striated muscle of Limulus. American Zoologist 25(4): 120A, 1985. Malathi, S. (1981) An Experimental study on the morphology of a peripheral nerve supplying an immobilized muscle in the cat. J. Anat. 133: p. 663, 1981. Proc. of the anatomical society of Great Britain and Ireland, Sheffield, U.K.

Jianfeng XU

Assistant Professor of Biochemical Engineering Arkansas Biosciences Institute, Arkansas State University

State University, AR 72467, USA Tel: (870)680-4812; Fax: (870)680-4348; E-mail: [email protected]

------------------------------------------------------------------------------------------------------------------------------- PERSONAL INFORMATION Gender Male

Date of Birth March 3, 1969 Place of Birth Zhejiang Province, China, P.R. Nationality China, P.R. RESEARCH INTERESTS

Plant cell/tissue culture; Plant cell wall protein and glycosylation;

Bioreactor design and operation; Recombinant protein expression and purification;

Algal culture for biodiesel production; Cell free protein expression and protein glycosylation

EMPLOYMENT August, 2008—now Assistant Professor of Biochemical Engineering

Arkansas Biosciences Institute, Arkansas State University State University, AR 72467 Projects: Plant cell/tissue culture for the production of therapeutic proteins Cell-free protein expression for synthesis of novel proteins

Algal culture for biodiesel production Anaerobic digestion for biogases production August, 2006—August, 2008 Research Associate/Senior Research Associate Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853 Mentor: Dan Luo (Associate Professor) Projects: Cell-free protein expression and site-specific protein glycosylation Protein engineering of cellulase and antimicrobial peptide Gold nanoparticle mediated gene/siRNA delivery July, 2000—August, 2006 Research Scientist

Edison Biotechnology Institute and Department of Chemistry and Biochemistry Ohio University, Athens, OH 45701 Also with Battelle Memory Institute, Columbus, OH 43201

Mentor: Marcia Kieliszewski (Professor) Projects: Plant cell culture for the expression of therapeutic proteins Molecular design and expression of biopolymers with plant cell cultures Elucidation of the Hydroxyproline-O-glycosylation code in plant cell wall proteins Molecular cloning of Gum arabic glycoprotein backbone gene

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August, 1998—June, 2000 Postdoctoral Research Associate Department of Chemical Engineering Ohio University, Athens, OH 45701 Mentor: Murray Moo-Young (Visiting Professor from University of Waterloo) Projects: Plant cell culture in bioreactor for the production of gum Arabic glycoprotein Separation and structural characterizations of Gum Arabic glycoproteins Aspergillus fermentation for the production of recombinant protein (interlukin-6, GFP) March, 1997—June, 1998 Postdoctoral Research Associate

State Key Laboratory of Biochemical Engineering, Chinese Academy of Sciences, Beijing, 100080, China Mentor: Zhiguo Su (Professor) Projects: Large-scale Taxus cell cultures for the Production of Paclitaxel (Taxol®)

Plant tissue culture for the production of peroxidase September, 1991—March, 1997 Research Assistant

Department of Biochemical Engineering, Dalian University of Technology, Dalian, 116023, China Mentor: Pusun Feng (Professor) Projects: Large scale plant cell cultures for the production of secondary metabolites

Filamentous fungi fermentation for the production of therapeutic polysaccharides EDUCATION Ph.D —1997 Biochemical Engineering Dalian University of Technology, Dalian, 116023, China Mentor: Pusun Feng Thesis: Process regulation and control of large-scale culture of Rhodiola Sachalinensis cells for the production of salidroside B.S. —1991 Environmental Engineering Dalian University of Technology, Dalian, 116023, China Mentor: Xie Quan

Thesis: Determination of prior order and classification of pullants with fuzzy mixed method INVITED LECTUERS

Hydroxyproline-O-glycosylation code of plant cell wall proteins and its novel applications. University of Arkansas at Little Rock. Little Rock, AR, Jan 26, 2009.

Plant Cell Culture--A Powerful Platform for the Synthesis of Therapeutic Proteins and Secondary Metabolites. Arkansas Biosciences Institute, Jonesboro, AR, May 11, 2008.

High-Yields and Extended Serum Half-Life of Human Growth Hormone Expressed as Fusion Glycoproteins in Plant Cells. Ambrx, La Jolla, CA, May 9, 2008.

High-Yields and Extended Serum Half-Life of Therapeutic Proteins Expressed as Fusion Glycoproteins in Plant Cells. Fraunhofer USA CMB, Newark, DE, April 17, 2007.

Plant Cell/Tissue Culture for the Production of Valuable Products. Phyton Biotech., East Windsor, NJ, Jan 28, 2006.

Design of HRGP-Based Bio-emulsifier. Battelle Memory Institute, Columbus, Columbus, OH, July 25, 2005.

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HONORS /AWARDS BP Young Scientist Award, 13th International Biotechnology Symposium & Exhibition, Dalian, China, 2008. China National Postdoctoral Research Funding granted, December, 1997 Xiang Fanglong Fellowship, Dalian University of Technology, October, 1995

An-Gang Fellowship, Dalian University of Technology, June, 1994 Excellent Graduate Student of Dalian University of Technology, July, 1991 Member of American Society of Plant Biologist (ASPB) Member of American Institute of Chemical Engineer (AIChE)

FUNDING RECEIVED

1. Laboratory Startup Funding—EPSCoR NSF, $150,000 (August, 2008--May, 2009) 2. Laboratory Startup Funding—ABI, $50,000 (June, 2009--May, 2010)

PUBLICATIONS Paper published in international journal 1 Jianfeng Xu, Shigeru Okada, Li Tan, John J. Kopchick and Marcia J. Kieliszewski. Human growth

hormone expressed in tobacco cells as a hydroxyproline glycoside fusion significantly secret into medium and has a prolonged circulating half life. Plant Biotechnol J. In revision. 2009

2 Nokyoung Park, Soong Ho Um, Hisakage Funabashi, Jianfeng Xu, Dan Luo. A Cell-free Protein Producing Gel (Full Article). Nature Materials. Accepted, 2009.

3 Jianfeng Xu, Li Tan, Derek T. A. Lamport, Allan Showalter and Marcia J. Kieliszewski. Biochemical characterization of hydroxyproline-rich glycoproteins expressed in Arabidopsis thaliana suspension cultured cells and proposed role of hydroxyprolyl-O-glycans in secretion. Phytochem. 2008, 69 (8): 1631-1640.

4 Jianfeng Xu, Li Tan, Kenneth J. Goodrum and Marcia J. Kieliszewski. High-yields and extended serum half-life of human interferon α2b expressed in tobacco cells as arabinogalactan-protein fusions. Biotechnol Bioeng. 2007, 97: 997-1008.

5 Marcia J. Kieliszewski and Jianfeng Xu, Synthetic genes for the production of novel Arabinogalactan-proteins and plant Gums. Foods and Food Ingredients Journal of Japan. 2006, 211: 32-37.

6 Jianfeng Xu, Elena Shpak, Tingyue Gu, Murray Moo-Young and Marcia Kieliszewski. Production of recombinant plant gum with tobacco cell culture in bioreactor and gum characterization. Biotechnol Bioeng. 2005, 90(5):578-588.

7 Wenxian Sun, Jianfeng Xu, Jie Yang, Marcia J. Kieliszewski and Allan Showalter. Expression and characterization of arabinogalactan proteins with a basic lysineprich subdomain in Arabidopsis. Plant Cell Physiol. 2005, 46(6)-975-984.

8 Fengwu Bai, Liping Wang, Jianfeng Xu, Jim Caesar, Darin Ridgway, Tingyue Gu, and Murray Moo-Young, Oxygen mass-transfer performance of low viscosity gas-liquid-solid system in a split-cylinder airlift bioreactor. Biotechnol. Lett. 2001, 23:1109-1113.

9 Dara O’Donnell, Liping Wang, Jianfeng Xu, Darin Ridgway, Tingyue Gu, and Murray Moo-Young, Enhanced heterologous protein production in Aspergillus niger through pH control of extracellular protease activity. Biochem Eng J. 2001, 8 (3): 187-193

10 Jianfeng Xu, Liping Wang, Darin Ridgway, Tingyue Gu and Murray Moo-Young. Increased heterologous protein production in Aspergillus niger fermentation through extracellular proteases inhibition by pelleted growth. Biotechnol. Prog. 2000, 16(2): 222-227

11 Xu Jianfeng, Ying Peiqing, Han Aiming, Su Zhiguo, Enhanced salidroside production by suspension culture of compact callus aggregates of Rhodiola sachalinensis: manipulation of plant growth regulators and sucrose. Plant Cell Tiss & Org Cult. 1999, 55(1): 53-58

12 J.F. Xu, Y. Sun, Z.G. Su, Enhanced peroxidase production by suspension culture of carrot compact callus aggregates. J Biotechnol. 1998, 65(2-3): 203-208

13 Xu, Jianfeng, Feng Pusun, Su Zhiguo, Compact callus aggregates suspension culture of Rhodiola Sachalinensis for improved production of salidroside. Enzyme Microb Technol. 1998, 23(1-2): 20-27

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14 Xu, Jianfeng, Xie Jian, Han Aiming, Feng Pusun, Su Zhiguo, Study on large-scale culture of Rhodiola sachalinensis compact callus aggregates with air-lift reactor for enhanced salidroside production. J Chem Technol Biotechnol. 1998, 72(3): 227-234

15 J. F. Xu, C. B. Liu, A. M. Han, P. S. Feng, Z. G. Su, Strategies for improvement of salidroside yield in suspension cell culture of Rhodiola sachalinensis A.Bor. Plant Cell Rep. 1998, 17(4): 288-293

16 Xu J. F., Su Z. G., Feng P. S., Activity of tyrosol glucosyltransferase and improved salidroside production through biotransformation of tyrosol in Rhodiola sachalinensis cell culture. J Biotechnol. 1998, 61(1): 69-73

17 Xu J. F., Xie J., Feng P. S., Su Z. G., Suspension nodule culture of the Chinese herb Rhodiola sachalinensis in an air-lift reactor: kinetics and technical characteristics. Biotechnol Techniq. 1998, 12(1):1-5

18 Xu J. F., Ying P. Q., Su Z. G., Self-immobilized cell culture of Taxus cuspidata for improved taxol production. Biotechnol Techniq. 1998, 12(3): 241-244

19 Zhang Zhiqiang, Wei Xingui, Tian Guilan, Xu Jianfeng, Su Zhiguo, Improved HPLC method for taxol determination with Al2O3 solid-phase extraction. Biotechnol Techniq. 1998, 12(8): 633-636

Paper published in Chinese journal 20 Jinafeng Xu. High-yield expression of therapeutic proteins with extended serum half-life in tobacco cells,

Chin J Biotechnol. 2008. 21 Ying Peiqing, Xu Jianfeng, Su Zhiguo. Studies on characteristics and kinetics of salvia miltiorrhiza crown

gall tissue culture. J Appl Environ Biol. 1999, 5(5): 478-482. 22 Xu Jianfeng, Xie Jie, Feng Pusun, Su Zhiguo, Study on kinetics and oxygen transfer characteristics of

suspension culture of Rhodiola sachalinensis callus aggregates with air-life reactor. Chemical Reaction Engineering and Technology. 1998, 14(3): 305-312.

23 Zhang Zhiqiang, Xu Jianfeng, Su Zhiguo. Decoloration and separation of Paclitaxel from Taxus Yunnanensis extract by macroreticular adsorbent resin. Journal of Chemical Engineering of Chinese Universities. 1999, 13(2):161-164.

24 Xu Jianfeng, Xie Jian, Li Ning, Feng Pusun, Structured model for compact callus aggregate suspension culture of Rhodiola sachalinensis. Journal of Dalian University of Technology. 1999, 39(1):43-48.

25 Xu J, Xie J, Feng P, Su Z, Oxygen transfer characteristics in the compact callus aggregates of Rhodiola sachalinensis. Chin J Biotechnol. 1998, 14: 99-107

26 Xu, Jianfeng, Su Zhiguo, Feng Pusun, Production of salidroside through biotransformation of exogenous tyrosol by Rhodiola sachalinensis cell suspension culture. Acta Botanica Sinica. 1998, 40(11): 1034-1041

27 Xu, Jianfeng, Liu Chuanbin, Feng Pusun, Effects of medium pH decrease on salidroside release and cell viability in cell suspension culture of Rhodiola sachalinensis A.Bor. Acta Botanica Sinica. 1997, 39(11): 1020-1027.

28 Xie Jian, Xu Jianfeng, Feng Pusun, Study on oxygen transfer characteristics within the compact callus aggregates of Rhodiola sachalinensis. Chinese Journal of Biotechnology. 1998, 14(2):160-165

29 Xu Jianfeng, Su Zhiguo, Feng Pusun, Regulation of metabolism for improved salidroside production in cell suspension culture of Rhodiola sachalinensis A. Bor I: The effect of precursor. Nature Product Research and Development 1998, 10(2):8-13.

30 Xu Jianfeng, Yin Peiqin, Feng Pusun, Advance on research and development of Rhodiola sachalinensis resources. Zhong Cao Yao 1998, 29(3):202-205.

31 Xu Jianfeng, Su Zhiguo, Feng Pusun, Regulation of metabolism for improved salidroside production in cell suspension culture of Rhodiola sachalinensis A. Bor II: The effect of elicitors. Nature Product Research and Development 1998, 10(3):6-11.

32 Han Aiming, Xu Jianfeng, Feng Pusun, Effects of some factors on cell growth and salidroside accumulation in suspension cultures of Rhodiola sachalinensis. Plant Physiol Comm. 1997,33(1):30-33.

33 Xu Jianfeng, Han Aiming, Feng Pusun, Growth and nutrients uptake kinetics and their stoichiometrical relations in Rhodiola sachalinensis A.Bor cell suspension culture. Chin J Appl Environ Biol. 1997,3(2):100-105

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34 Xu Jianfeng, Han Aiming, Feng Pusun, Studies on kinetics and technique characteristics of Rhodiola Sachalinensis A. Bor callus suspension culture. Chin J Biotechnol 1996, 12(4): 460-465

35 Xu Jianfeng, Feng Pusun, Induction and culture of calli from Rhodiola sachalinensis A.Bor. Chin J Appl. Environ. Biol. 1995,1(1):19-25

36 Quan Xie, Xu Jianfeng, Yang Fenglin, Lang Peizheng, Determination of prior order and classification of pullants with fuzzy mixed method. Journal of Dalian University of Technology.1993, 33(4): 403-406.

Book chapter 1. Wenlong Cheng, Liang Ding, Hisakage Funabashi, Nokyoung Park, Soong Ho Um, Jianfeng Xu,

Dan Luo, Nucleic Acid Engineering-Towards Synthetic Biology. In: Systems biology and synthetic biology. Wiley, March 2009.

Patents 1. Marcia Kieliszewski, Jianfeng Xu and Gary Meyer. Methods of producing peptides/proteins and

peptides/proteins produced thereby. U.S. Utility Patent. Publication No. US-20060026719.

European Patent. Publication No. EP1711533. International Patent. Publication No. WO/2005/069845 Canadian Patent. Publication No. CA 2553257

2. Marcia Kieliszewski, Jianfeng Xu, John J, Kopchick and Shigeru Okada. Glycoproteins produced in

plants and methods of their use. U.S. Utility Patent. Publication No. US-20060148680. 3. Marcia Kieliszewski, Jianfeng Xu, Stevens Timothy, and Dupree Paul. Method of predicting Hyp-

glycosylation sites for protein expressed and secreted in plant cells, and related methods and products. International Patent. Publication No. WO/2007/008708. U.S. Utility Patent Pending. Application No. 11/995, 063. 4. Marcia Kieliszewski, Jianfeng Xu and Iver Cooper. Co-expression of proline hydroxylases to facilitate

Hyp-glycosylation of proteins expressed and secreted in plant cells. International Patent. Publication No. WO/2008/008766

U.S. PCT Patent Applications. Application No. 60/746,141. 5. Marcia Kieliszewski, Jianfeng Xu. Enhanced secretion of human growth hormone from transgenic

tobacco cells by introduction of an N-Glycosylation site. U.S. PCT Patent Applications. Application No. 60/819, 557. 6. Marcia Kieliszewski, Jianfeng Xu, Gary Meyer, Shigeru Okada, and John J, Kopchick. High-yields and

extended serum half-life of human interferon alpha-2 and human growth hormone expressed in tobacco cells as arabinogalactan-protein fusion glycoproteins.

U.S. PCT Patent Applications. Application No. 60/746,146. Meeting abstract and presentation 1. Jianfeng Xu and Marcia Kieliszewski. High-yield Expression of Therapeutic Proteins with Extended

Serum Half-life in Tobacco Cells. Presented on the 13th International Biotechnology Symposium & Exhibition. Dalian, China. October, 2008.

2. Xu JF and Kieliszewski M. A new Platform for High-Yield Secretion of Therapeutic Proteins in Plant Cell/Tissue Cultures. Presented on the Annual NSF EPSCoR meeting. Little Rock, October, 2008.

3. Xu JF, Park, N and Luo D. A Novel DNA Hydrogel Can Synthesize Proteins with High Yield and Efficiency without Living Cells. Presented on Cornell Nanobiotechnology Center (NBTC) annual meeting. Ithaca, March, 2008.

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4. Xu JF, Park, N and Luo D. Cell Free Synthesis of Bioadhesive Protein mefp-1 in High Yield via a Novel DNA Hydrogel. Presented on Materials Research Society (MRS) Fall Meeting. Boston, November, 2007.

5. Tan L, Xu JF, Qiu F, Lamport DAT and Kieliszewski M. The AGP Hyp-arabinogalactan backbone is a folded polysaccharide of reverse-turn hairpins generated by &beta-(1-6) linked repeats of &beta-(1-3) trigalactosyl units. Presented on The XIth Cell Wall Meeting (2007). Copenhagen, Denmark 12-17, August 2007.

6. J. Xu, M. J., S. Okada and J. J. Kopchick. High-yields and extended serum half-life of therapeutic proteins expressed as fusion glycoproteins. Presented on The Society of In Vitro Biology (SIVB) 2006 Meeting, June, 2006, Minneapolis, USA.

7. Jianfeng Xu and Marcia Kieliszewski. High yield production of recombinant plant gum with tobacco cell culture. Presented on the Annual meeting of American Institute of Chemical Engineers (AIChE). November, 2005, Cincinnati, USA.

8. Xu JF, Kieliszewski M. Expression of Gum Arabic Glycoprotein Analogs with Transgenic Tobacco Cells. Presented on The Annual Meeting of the American Society of Plant Biologists (ASPB). July, 2004, Orlando, USA.

9. Xu JF, Kamyab A, Kieliszewski M. Production of genetically engineered biopolymers in plant cells. Presented on The Annual Meeting of the American Society of Plant Biologists (ASPB). August, 2002, Denver, USA.

10. Jianfeng Xu, Marcia Kieliszewski, Synthetic gum arabic glycoprotein production by transgenic tobacco cell cultures: Technological characterization. Presented on The Annual Meeting of the American Society of Plant Physiologists (ASPB). July, 2000, San Diego, USA.

11. Moo-Young M, Scharer JM, Yahya A, Gu T, O'Donnell D, Papagianni M, Xu J. Enhancement of heterologous protein production with cell immobilization in filamentous fermentation processes. Abstracts of Papers of The American Chemical Society 219: U223-U223 337-BIOT Part 1, MAR 26 2000.

12. Jianfeng Xu, Dara O’Donnell, Liping Wang, Maria Papagianni, Niren Joshi, Darin Ridgway, Tingyue Gu, and Murray Moo-Young. Bioprocessing strategies for the inhibition of proteases in recombinant Aspergillus Niger fermentation. Presented on The Annual meeting of American Institute of Chemical Engineers (AIChE). December, 1999, Dallas, USA.

13. Xu Jianfeng, Han Aiming, Feng Pusun and Su Zhiguo. Suspension culture of compact callus aggregates of Rhodiola sachalinensis: a high potential for improved salidroside production. Presented on The 4thAscia-Pacific Biochemical Engineering Conference (APBioChEC’97). Octorber, 1997, Beijing, China.

14. Xu Jianfeng, Fang Xiaodan, Liu Chuanbin, Feng Pushun, Salidroside biosynthesis regulation in cell suspension culture of Rhodiola sachalinesis. Presented on The 2rd Asia-Pacific Conference on Plant Cell and Tissue Culture (APCPCTC), July, 1996, Beijing, China.

15. Jianfeng Xu, Aiming Han, Punsun Feng. Process control and technological properties in callus grain suspension culture of Rhodiola sachalinensis A. Bor. Presented on The 7th National Conference on Biochemical Engineering, July, 1996, Dalian, China

16. Jianfeng Xu, Aiming Han, Punsun Feng. Study on cell suspension culture of Rhodiola sachalinensis A. Bor. Presented on The 6th National Conference on Biochemical Engineering, July, 1995, Xi’an, China.

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http://apps.isiknowledge.com/WoS/CIW.cgi?SID=3Cmld7JlbLKi1l4jD14&Func=OneClickSearch&field=AU&val=Yahya+A&ut=000087246101061&auloc=3&curr_doc=22/1&Form=FullRecordPage&doc=22/1

http://apps.isiknowledge.com/WoS/CIW.cgi?SID=3Cmld7JlbLKi1l4jD14&Func=OneClickSearch&field=AU&val=Gu+T&ut=000087246101061&auloc=4&curr_doc=22/1&Form=FullRecordPage&doc=22/1

http://apps.isiknowledge.com/WoS/CIW.cgi?SID=3Cmld7JlbLKi1l4jD14&Func=OneClickSearch&field=AU&val=O'Donnell+D&ut=000087246101061&auloc=5&curr_doc=22/1&Form=FullRecordPage&doc=22/1

http://apps.isiknowledge.com/WoS/CIW.cgi?SID=3Cmld7JlbLKi1l4jD14&Func=OneClickSearch&field=AU&val=Papagianni+M&ut=000087246101061&auloc=6&curr_doc=22/1&Form=FullRecordPage&doc=22/1

http://apps.isiknowledge.com/WoS/CIW.cgi?SID=3Cmld7JlbLKi1l4jD14&Func=OneClickSearch&field=AU&val=Xu+J&ut=000087246101061&auloc=7&curr_doc=22/1&Form=FullRecordPage&doc=22/1

Appendix C

Syllabi of MBS Core Courses ASU Policies for the Introduction of New Courses

Course Syllabus

Advanced Cell Biology (MBS 6213)

Spring 2009

Class meetings Mon and Wed 10:30 - 11:45 pm, ABI #220

Coordinator: Dr. Soo Ahn, ABI #212, 972-2802, 680-4798, [email protected]

Instructors:

Soo Ahn 4798 [email protected]

Carole Cramer 2025 [email protected]

Anne Grippo 3493 [email protected]

Elizabeth Hood 2694 [email protected]

Malathi Srivatsan 3082 [email protected]

Guest Instructor (Mar 2nd

):

Fabricio Medina-Bolivar 4319 [email protected]

Course Goals:

The goal of this course is to develop a working knowledge of recent advances in important topics in cell

biology through study of current scientific literature. Upon completion of the course, students will be able

to critically assess the primary literature in the area of cell and molecular biology, to become familiar with

common and newly developing techniques in this field and to integrate this knowledge into their research.

Text:

There is no text; journal articles or other literature selections chosen by instructors will be available to

students prior to discussion.

Grades: 80% Take-home exam (20% 4 topics)

10% Writing assignment

10% In-class Participation








Take Home Exams:

After each topic, instructors will give out take-home exams. Each take-home exam will contain multiple

questions which require critical thinking. There will be a total of 4 take-home exams through the semester

(for Topics 3 through 6, please see the outline below), and each take-home exam will be 20% of a

student’s total grade. Details for each take-home exam (including due date) will be provided by each

instructor. There is no final exam for this course.

Writing Assignments:

Students will be given two writing assignments. For the first one (due on Jan 26th ), students will be write

a 1-page abstract of their current research project highlighting potential cell biology techniques used for

the project. For the second one (due on Feb 16th), students will be expected to write a revised 1-page

abstract of their research project. In this revised version, students should describe the techniques that may

be used in their research along with alternative techniques that could be used and why they have chosen

the specific techniques (justification).

These two writing assignments will be 10% of the total grade. Students will be graded not only on the

content of their assignments, but also on their writing skills (grammar, punctuation).

Class Attendance: Student attendance is required in every lecture. Students who miss a class should

notify the professor in advance.

Academic Integrity: Academic Integrity Policy from the Arkansas State University Student’s Handbook

will be enforced on the case of infringement of academic integrity, including plagiarism and cheating.

Disability Clause: Students who require academic adjustments in the classroom or modifications in

course requirements due to a disability must first register with ASU Disability Services. Following

registration and within the first two weeks of class, contact the professor to discuss appropriate academic

accommodations. Appropriate arrangements can be made to ensure equal access to this course.

Flexibility Clause: Circumstances may arise during the course that may prevent the instructors from

fulfilling each and every component of this syllabus. Therefore, the syllabus should be viewed as a guide

and is subject to change. Students will be notified of any changes.

Tentative course outline

Weeks Dates Topics Instructors

1 Jan 12 , 14 1. General Cell Biology Review Ahn

2 Jan 19 (no class), 21

3, 4, 5 Jan 26 to Feb 11

2. Cell Biology Techniques

(1) Molecular tools (Jan 26, 28)

- Ahn

(2) Microscopy (Feb 2) –

Srivatsan

(3) Organelle isolation and

immunological tools (Feb 4)

- Cramer

(4) Cell & Tissue culture:

Animal cell (Feb 9, Grippo),

Plant cell (Feb 11, Hood)

Ahn/ Srivatsan/Cramer/

Grippo/Hood

6, 7, 8 Feb 16 to Mar 4 3. Pathogen-Host Cell Interactions

Ahn (Feb 16 to 25)

Medina-Bolivar (Mar 2)

Cramer (Mar 4)

9 Mar 9, 11

4. Protein Trafficking/Targeting Cramer 10 Mar 16, 18

11 Spring break

12 Mar 30, Apr 1

5. Cancer /Apoptosis

Grippo (Mar 30 to Apr 6)

Srivatsan (Apr 8 to 15)

13 Apr 6, 8

14 Apr 13, 15

15 Apr 20, 22 6. Cell structure (cell walls,

cytoskeletons) and cell movement Hood

16 Apr 27

F. Medina-Bolivar MBS 6233/BIO 6123/CHEM 6233

SPECIALIZED BIOCHEMISTRY

Course Syllabus MBS 6233 / BIO 6123 / CHEM 6233 Spring 2009

Instructor: Dr. Fabricio Medina-Bolivar (680-4319; [email protected]) Course Description: An advanced study of biochemical pathways leading to specialized biologically active metabolites. Emphasis will be on specialized pathways in plants and their counterparts in animals, and microorganisms. Aspects of metabolic engineering, chemical ecology and applications of specialized metabolites in medicine and agriculture will be discussed. Lectures: T R, 9:30 – 10:45 am; 320 ABI; 3 credit hours Office Hours: W, 2:00 – 3:00 pm or by appointment Prerequisite: Biochemistry (4243/5243) or equivalent; Basic knowledge of plant physiology and molecular biology. Textbook: Biochemistry and Molecular Biology of Plants, by Buchanan, Gruissem, Jones (American Society of Plant Biologists). Additional required reading materials will include research papers, reviews and handouts. The following supporting textbooks are available free in the internet through NCBI: (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books&itool=toolbar) Biochemistry, by Berg, Tymoczko and Stryer (W.H. Freeman and Co.) Sequence-Evolution-Function, by Koonin and Galperin (Kluwer Academic Publishers)

Grading: Class participation 10 % Quizzes 10 % Paper presentation 10 % Research proposal (written 10%, oral 10%) 20 % Term exam I 15 % Term exam II 15% Final comprehensive exam 20 % Other: The Honor Code will be strictly enforced. Students with special instructional needs related to learning or testing in this course, please let the course coordinator know as soon as possible so those needs can be addressed.


PROPOSAL GUIDELIDES DEADLINE: April 21, by 5 pm - Handwritten proposals will not be accepted. Proposals need to be sent by e-mail (pdf format) to [email protected].

– NO EXTENSIONS WILL BE PROVIDED! FORMAT:

1. ABSTRACT: 400 words or less

2. NARRATIVE: Limited to five single-spaced pages explaining the project (including Figures). Font Arial 11 required.

a. Background and Hypothesis

b. Objectives (3 maximum)

c. Methodology

d. Timeline (24 months)

e. Expectations and alternate experiments

3. REFERENCES


CLASS OUTLINE

Weeks 1-2 (Jan 13, 15, 20, 22) Principles of specialized metabolism: compartmentalization, channeling, coordinated gene expression Biochemical and molecular methods used to study metabolic pathways Biotechnological and analytical tools to study metabolic pathways. Week 3 (Jan 27, 29) Terpenoids Cytosolic and plastidic terpenoid pathways Weeks 4-5 (Feb 3, 5, 10, 12) From monoterpenes to sterols Phytoalexins: the chemical defense of plants Plant versus animal sterols Terpenoids – metabolic engineering Lab demonstration Feb 12 Week 6 (Feb 17, 19) Exam I (Feb 17) Exam discussion Phenolics and phenylpropanoids Week 7, 8 (Feb 24, 26; Mar 3, 5) Phytoestrogens Plant pigments Phenolics - metabolic engineering Phenolics - medical applications Week 9 (Mar 10, 12) Non-protein amino acids Opines, Agrobacterium and genetic engineering Exam II (Mar 12)


Week 10 (Mar 17, 19) Exam discussion Alkaloid biosynthesis Week 11 (Mar 24, 26) SPRING BREAK Week 12 (Mar 31, Apr 2) Alkaloids – metabolic engineering Alkaloids – medical applications Week 13 -14 (Apr 7, 9, 14, 16) Oral Research Project Presentations Week 15-16 (Apr 21, 23, 28, 30) Chemical ecology Microbial metabolism Overall course review Written Project Deadline (April 21) Final Comprehensive Exam (April 30)

MOLECULAR GENETICS AND GENOMICS

Course Syllabus

MBS 6243 Fall 2008

Instructor

Argelia Lorence, Ph.D.

Assistant Professor in Metabolic Engineering

Office: ABI 310

Email: [email protected]

Office: (870) 680 4322

Unless special circumstances, I don’t check e-mail after 10:00 pm, so please consider that

when you send messages about urgent matters.

Class meetings Monday and Wednesday 9:30 to 11:00 am

ABI 320

Office hours M and W 3:00 to 5:00 pm and by appointment

Course description

This course will present a new approach to a graduate level course of genetics, molecular

biology and its applications to microbes, animals and plants. The course will integrate formal

genetics – the rules by which genes are transmitted; molecular genetics – the structure of DNA

and how it directs the structure of proteins and genomics and information science – the new

technologies that allow gene isolation and a comprehensive analysis of the entire gene set in an

organism. Upon completion of the course, students will be able to describe the techniques of

recombinant DNA technology and analysis of gene expression and be able to understand the

application of these tools to prokaryotic and eukaryotic systems.

Textbook

Hartwell L, Hood L, Goldberg ML, Reynolds AE, Silver LM, and Veres R (2008). “Genetics:

From Genes to Genomes”, 3rd edition, McGraw-Hill

Additional reading materials from current peer-reviewed papers, reviews and handouts

will be provided by the instructor. Support textbooks are freely available at NCBI:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books&itool=toolbar


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books&itool=toolbar

Exams and assignments

During the semester there will be four partial exams. These tests will consist primarily of

true/false and multiple choice questions, in addition to definitions, concepts, and short-answer

questions. However, the instructor has the option to use other types of evaluation tools. All

assignments are due at the beginning of the class. There will be deductions for late assignments

(10% per day).

Academic dishonesty

Academic dishonesty will not be tolerated. Examples of academic dishonesty include

but are not limited to cheating and plagiarism. Infractions will be reported and handled according

to ASU policy.

Course evaluation

Four in-class exams 12.5% each (50%)

Major assignment 1 (oral presentation) 15%

Major assignment 2 (proposal, essay) 15%

Minor assignments and class participation 20%

Grading

A= 90+, B= 80~89, C=70~79, D= 60-69, F=below 60%

Make-up exams

Students must take the exams on the scheduled days. There will be no make-up exams

except verifiable emergencies or legitimate reasons (illness, family emergency). In those

excusable circumstances, students must notify the instructor prior to the scheduled exam

and provide proper proof afterwards. There will be no exceptions.

Class attendance and cell phone policy

Student attendance is required in every lecture. Students who have an academic or a

legitimate personal reason to miss a class should notify the instructor in advance. Cell phones

must be off during classes and exams.

Disability clause

Students who require academic adjustments in the classroom or modifications in course

requirements due to a disability must first register with ASU Disability Services. Following

registration and within the first two weeks of class, students should contact the instructor to

discuss appropriate academic accommodations. Appropriate arrangements can be made to ensure

equal access to this course.

Flexibility clause

Circumstances may arise during the course that may prevent the instructor from fulfilling

each and every component of this syllabus. Therefore, the syllabus should be viewed as a guide

and is subject to change. Students will be notified of any changes to the syllabus or the

organization of the class.

Tentative course outline

Date Lecture Outline Reading Assignment/

Exam

Week 1 Genetics: Introduction & review Chapters 1,2

Week 2 Inheritance of genetic material Chapters 3,4

Week 3 DNA replication and

recombination Chapter 6

Week 4 Gene expression Chapter 8 Partial exam 1

Week 5 Prokaryotic chromosome Chapter 15

Week 6 Prokaryotic gene regulation Chapter 17

Week 7 Genomes – analyses of genomes Chapters 9, 10 Partial exam 2

Major assignment 1

Week 8 Detection of genotype/proteomics Chapters 11, 12

Week 9 Eukaryotic chromosome Chapters 13, 14

Week 10 Eukaryotic gene regulation Chapter 18

Week 11 Gene mutation Chapter 7 Partial exam 3

Week 12 Genetics of cancer Chapter 19

Week 13 Developmental genetics Chapter 20

Week 14 Evolution at the molecular level Chapters 21, 22

Last day of class Major assignment 2

Final examination Partial exam 4

F. Medina-Bolivar MBS 6251-001

TECHNIQUES IN MOLECULAR BIOSCIENCES - MBS 6251

HAIRY ROOTS: CULTURE AND APPLICATIONS – 1 CREDIT

Course Syllabus Fall 2008

Instructor: Dr. Fabricio Medina-Bolivar (680-4319; [email protected]) Course Description: Lectures, research paper discussions and laboratory practices focused on hairy root culture and its applications in biotechnology. Laboratory practices will focus on: development of hairy roots, maintenance, molecular screening, elicitation of specialized metabolites and production of recombinant proteins. Lectures and laboratory practices: ABI 320 and 332; Thursdays 9 am-10 am or as scheduled. Office Hours: Wednesday 9-10 am or by appointment. Prerequisite: Basic knowledge of plant physiology and molecular biology. Textbook: Required reading materials will include research papers, reviews and handouts. The following supporting textbooks are recommended: Hairy Roots: Culture and Applications. 1997. Dolan P (Ed.). Hardwood Academic Publishers, Amsterdam. 239 p. Agrobacterium: From Biology to Biotechnology. 2008. Tzfira T and Citovsky V (Eds.). Springer, New York. 750 p.

Grading: Class participation 10 % Quizzes 10 % Laboratory reports 50 % Research proposal (oral 10%; written 20%) 30 % Other: The Honor Code will be strictly enforced. Students with special instructional needs related to learning or testing in this course, please let the course coordinator know as soon as possible so those needs can be addressed.


PROPOSAL GUIDELIDES

DEADLINE: December 1, before 5 pm - Handwritten proposals will not be accepted.

Proposals need to be sent by e-mail (pdf format) to [email protected]. – NO EXTENSIONS WILL BE PROVIDED!

FORMAT:

1. ABSTRACT: 400 words or less

2. NARRATIVE: Limited to five single-spaced pages explaining the project (including Figures). Font Arial 11 required.

a. Background and Hypothesis

b. Objectives (3 maximum)

c. Methodology – SHOULD INCLUDE HAIRY ROOT APPLICATIONS

d. Timeline (12-18 months)

e. Expectations and alternate experiments

3. REFERENCES


CLASS OUTLINE

1. Establishment of hairy roots

2. Subculture and scale up of hairy roots

3. Molecular characterization of hairy roots

4. Elicitation and analyses of specialized (secondary) metabolites

5. Production of recombinant proteins

MBS 7151 Responsible Conduct in Research Fall 2008 Wed 5 to 7 PM Instructor: Dr. Roger Buchanan, Director Graduate Program in Molecular BioSciences

ABI 211 680.4297 [email protected] Course goals

We seek to provide a learning experience for students that will enable them to: 1. Develop and refine skills needed to solve problems involving relevant topic areas

of responsible scientific conduct 2. Be able to clearly articulate -- both verbally and in writing -- ethically and legally

acceptable solutions to problems posed about scientific conduct 3. Develop a positive attitude towards life long learning in the matters of scientific

integrity and responsible research conduct Specific Course Objectives

Students successfully completing this course will: 1. Be familiar with relevant written guidelines bearing on the conduct of scientific

research including those dealing with scientific authorship, use of humans and animals in research, academic honor standards, conflict of interest, collaborative research, and general standards of scientific conduct

2. Be familiar with statutes that govern the ownership, protection, and use of intellectual property in the arena of scientific research

3. Be able to describe conventions and normative behavior related to responsibilities in the scientific mentor-trainee relationship

4. Be able to describe the conventions of scientific record keeping and have a clear understanding of data ownership issues

5. Be able to describe the relevant issues and dilemmas related to the impact of genetic technology on human subject research and on society in general

Required Text Macrina FL (2005): Scientific Integrity, Third Edition. ISBN: 1-55581-318-6 (Available at the ASU Bookstore)

Course Structure The course consists of 8 2-hour sessions for a total of (1 cr. hr.). All sessions consist of presentation of information, issues and cases by the instructor or led by students. For some topics, students conduct surveys (e.g., survey on attitudes about mentorship responsibilities), tabulate results, and then use these data to lead class discussion. Grading The final grade (A-F) in the course is determined based on the following weighting:

• 15% of the grade is based on attendance; • 25% of the grade is based on class participation. • The remaining 60% of the grade is based on discussion summaries by the

group leader (25%), student-written case studies (10%) and a written assignment (5 page term paper, 25%).

SCHEDULE Date Topic Chapter Case Study/

Survey Week 1 Scientific

Integrity Chapter 1 Student(s)

Week 2 Ethics and the Scientist Mentoring

Chapter 2 Chapter 3

Week 3 Ownership of Data and Intellectual Property Conflict of Interest

Chapter 9 Chapter 7

Week 4 Scientific Record Keeping and Data Sharing

Chapter 11

Week 5 Collaborative Research Chapter 8

Week 6 Use of Humans in Biomedical Experimentation Use of Animals in Biomedical Research

Chapter 5 Chapter 6

Week 7 Authorship and Peer Review

Chapter 4

Week 8 Genetic Technology and Scientific Integrity

Chapter 10

Spring 2008

MBS 6251 - TECHNIQUES IN MOLECULAR BIOSCIENCES

Syllabus for MBS Techniques Module: Genomics and Bioinformatics

Instructor: Dr. Xiuzhen Huang

Office: CSM 128 Phone: 870-972-3978


Credit Hour: 1 credit

Class Meeting Room: ABI 229

Class Meeting Time: Wednesday 9:00am-12:00pm

Grading Policy:

• Three group lab projects: 100pts * 3

• Four Homework: 100pts * 4

• One quiz (tentative): 300pts

Course Description: Bioinformatics is an extensive research area, which ties together

the life sciences and makes major contributions to, functional, comparative and structural

genomics, proteomics and pharmacogenomics. Bioinformatics makes it possible for

biological research to make the transition from an area low in data intensity, to one which

is highly data-intense. This new MBS course on Techniques Module in Bioinformatics

will teach the students how to effectively search genome databases and how to apply

basic bioinformatics tools and techniques for real biological data analysis.

The following is a list of tentative topics:

DNA and Protein Sequences (3 hrs) Students will learn to find a gene within a DNA

sequence. Then they predict the function of the implied protein product and find a 3D

modeling template for this protein sequence.

BLAST Search (3 hrs) This topic covers a practical introduction to the BLAST family

of sequence-similarity search programs. Students will learn the creative uses of the

BLAST programs to perform specialized searches.

Structural Analysis (3 hrs) This topic covers how to visualize and annotate 3D protein

structures using Cn3D. We will learn how to use bioinformatics software to identify

conserved domain(s) present in a protein, and how to find proteins with similar structures

in the PDB.

MicroArray Analysis (3 hrs) This topic covers bioinformatics software and approaches

for DNA microarray analysis. We will talk about pre-processing of microarray data,

analysis of differentially expressed genes to search for up- or down- regulated genes, and

analysis of relationships between genes to identify genes or samples that behave in a

similar or coordinated manner.

Basis of Bioinformatics Algorithm Design (3hrs) Students will learn how to model a

real-life biological problem as a computer science problem, develop efficient

bioinformatics approaches, and then apply the approaches to do biological data analysis.

Other topics (3 hrs) We will cover one or two other selected topics, in which students

show great interest.

Techniques in Molecular Biosciences (MBS 6251-001)

“Essential Tools for Protein Analysis and Purification”

Spring semester, 2008

Instructors: Dr. Brett J. Savary Dr. Prasanna Vasu

307 ABI 361 ABI

680-4792 680-4793

This new 1 credit course will combine lectures with hands-on demonstrations and laboratory

exercises to emphasize acquisition of practical skills for preparing proteins, evaluating them, and

purifying them. This will be accomplished through experiments to purify the plant cell wall

enzyme pectin methylesterase from fruit tissues.

This class will meet for four weeks, Tuesdays and Thursday, 1 PM to 5 PM, March 25 and 27,

April 1 and 3, April 15 and 17, and April 22 and 24. We will meet first in rm. 320 for lecture-

type introduction to the day’s materials. Demonstration activities and laboratory exercises will

follow in rm. 361. Students will work in teams of 2 or 3 for laboratory exercises.

Laboratory activities:

LAB 1, March 25

• Enzyme extraction from plant tissue and ammonium sulfate precipitation.

LAB 2, March 27

• Determination of protein content by spectrophotometric protein assay.

LAB 3, April 1

• Determination of enzyme assay by pH-stat titration assay.

LAB 4, April 3

• Analysis of proteins by SDS-PAGE.

April 8 and 10 – No class meeting this week. Laboratory is available, if needed.

Lab 5, April 15

• Cation-exchange chromatography separation and fraction analysis.

Lab 6, April 17

• Continue sample analysis.

Lab 7, April 22

• Affinity chromatography separation and fraction analysis.

Lab 8, April 24

• Run final SDS-PAGE and complete analyses for report.

Grading:

Quizzes (2) 30% Two quizzes.

Lab 10% Participation in lecture discussion, lab participation, completing course

evaluation.

Final report 60% Technical report on enzyme analysis and purification. Due May 5.

Technical report

You will prepare a short technical report presenting the results from your laboratory exercises on

the preparation of a fruit pectin methylesterase. Please keep this simple, but be sure it is

complete for the exercises covered. If you have any questions about this – you are responsible to

check with the instructor for assistance or clarification.

Contents are to include:

Introduction

Keep brief. Identify any previous or related work with the enzyme and/or species you worked

with. State the objective or purpose of your experiments. Suggestions for this – look up (e.g.,

Google and Pubmed) what has been done with this enzyme, why it is enzyme important in (e.g.,

in plant development, biochemistry or physiology, or post harvest fruit technology.)

Materials and methods

Brief summary of methods used (general details).

Results and Discussion

Summarize the results in figures and/or tables. These must include:

1. Purification table.

2. Ion-exchange chromatogram. Includes 280 nm absorbance trace and overlay of relative

activity in fractions.

4. Affinity purification chromatogram. Similar show activity in fraction in overlays of protein

contents.

5. SDS-PAGE analysis – includes sample from each step through purification sequence to final

fraction.

Purification table:

Purification Step

Volume

Protein

(mg/ml)

Activity

(U/ml)

Specific

Activity

Step Yield

Purification

Factor

Cell wall extract

Ammonium sulfate

(25% - 85%)

Dialysis/Concentration

Cation-exchange

Peak 1

Peak 2

Affinity purification

Peak 1

Peak 2

The SDS-PAGE gel figure should include samples from the four major treatments (and a lane

with molecular weight markers) to visualize enrichment of the enzyme through the purification

sequence.

TOPICS IN MOLECULAR BIOSIENCES

MBS 7123

Spring 2007

Course Outline:

Date Instructor Topic

Jan. 9-18 Dr. Carole Cramer (BIO/AG) Avian influenza – from virus to vaccines

Jan. 23-Feb. 1 Dr. Pam Weathers (AG) In planta production using bioreactors

Feb. 6-15 Dr. Roger Buchanan (BIO)

Neurological responses to plant derived

chemicals (drugs)

Feb. 20-Mar. 1 Dr. Fabricio Medina-Bolivar

(BIO)

Hairy roots as chemical factories

Mar. 27-Apr. 5 Dr. Argelia Lorence (CHEM) Plant antioxidants: a tale of multiple

faces

Apr. 10-19 Dr. Brett Savary (AG) Plant cell wall polysaccharides and

related enzyme systems

Apr. 24-May 3 Dr. Soo Ahn (AG) Pathogen detection and biosensor

development

Time: 3:30 to 4:45 T,Th

Room: 220 ABI

Coordinator: Carole Cramer, ABI, 972-2025, [email protected]


TOPICS IN MOLECULAR BIOSCIENCES

MBS 7123 (73989 MBS 712V), Spring 2007, 3 Credits

Course Syllabus

Time: 3:30-4:45 Tu, Th

Room: 220 ABI

Instructors: Coordinator: Carole Cramer, 102 ABI, 972-2025, [email protected]

Soo Ahn 4798 [email protected]

Roger Buchanan 4297 [email protected]

Argelia Lorence 4322 [email protected]

Fabricio Medina-Bolivar 4319 [email protected]

Brett Savary 4792 [email protected]

Pam Weathers 4795 [email protected]

Course Goals: The goal of this course is to expose students to a diverse set of topics outside

of their own primary research interests by examining seven different areas in

depth. It will be assumed that students have a basic biochemistry,

genetics, molecular or cell biology background. The course will focus on a

discussion of papers. The experimental design, methodology, and conclusions

reached in the papers will be critically analyzed.

Text: There is no text; readings will consist of assigned journal articles (to be

arranged by the instructors). All journal articles will be posted on Blackboard.

It is the student’s responsibility to access all reading materials through

Blackboard.

Grades: The focus of this course will be in-class discussion of assigned papers,

therefore, participation in the discussions will constitute the major portion of

the grading. In addition, there will be written take-home exams. Each of the

seven sections is worth 15 points for a total of 105 points (each section

consisting of 10 points for in-class discussion and 5 points for the written

exam). There is no final exam. If an instructor selects to alter the distribution

of points (discussion versus exam), this change will be provided in writing to

the students at the beginning of that instructor’s section.

Discussion 70 points

Written exams 35 points

Total: 105 points

Other: The Honor Code will be strictly enforced. Students with special

instructional needs related to learning or testing in this course, please let the

course coordinator know as soon as possible so those needs can addressed.









MBS 7123 (64635 MBS 712V), Fall 2007, 2 Credits

Course Syllabus

Time: 12:30-1:45, Tuesday and Thursday

Room: 320 ABI

Instructors: Coordinator: Brett Savary, 307 ABI, 680-4792, [email protected]

Malathi Srivatsan 3167 [email protected]

Jennifer Bouldin 2570 [email protected]

Xiuzhen Huang 3978 [email protected]

Carole Cramer 2025 [email protected]


of their own primary research interests by examining seven different areas in

depth. It is assumed that students have a basic biochemistry, genetics,

molecular or cell biology background. The course will provide an

introduction to various topics in Molecular Biosciences, with focus on a

discussion of research papers. The experimental design, methodology, and

conclusions reached in the papers will be critically analyzed.

Text: There is no text; readings will consist of assigned journal articles or other

material designated by the instructors. All journal articles will be posted on

Blackboard. It is the student’s responsibility to access all reading materials

through Blackboard.

Grades: The focus of this course will be in-class discussion of assigned papers,

therefore, participation in the discussions will constitute the major portion of

the grading. In addition, there will be a written take-home quiz or related

assignment. Each of the four Sections is worth 25 points for a total of 100

points. Bonus points (5) are provided upon completion of a class evaluation

with complete comments. Each of four class meetings for each Section is

worth 5 points for in-class participation (contributing to discussion of research

articles) and 5 points for the written exam. There is no final exam. If an

instructor selects to alter the distribution of points (discussion versus exam),

this change will be provided in writing to the students at the beginning of that

instructor’s section.

Participation 80 points


Evaluation 5 points

Total: 105 points










MBS 7123

Spring 2009

Course Outline:

Date Instructor Topic

Jan. 13-22

(exam 1/27)

Dr. Carole Cramer

(ABI/BIO/AG)

Human genetic diseases and development

of replacement enzyme therapeutics

Jan. 29-Feb. 10

(exam 2/12)

Dr. Jay Xu

(ABI/AG)

Plant cell wall hydroxyproline-rich

glycoproteins and novel applications

Feb. 17-26

(exam 3/3)

Dr. Vipin Nair

(ABI)

Cytochrome P450s and their many

biological roles

Mar. 5-17

(exam 3/19)

Dr. Ganapathy Sivakumar

(ABI)

Biofuels and algal biodiesel

Mar. 31- Apr. 9

(exam 4/14) Dr. Walter Suza

(ABI)

Jasmonate metabolism and signaling in

plants

Time: 3:30 to 4:45 T,Th

Room: 220 ABI

Coordinator: Carole Cramer, ABI, 972-2025, [email protected]



MBS 7123 (14009 MBS 712V), Spring 2009, 3 Credits

Course Syllabus

Time: 3:30-4:45 Tu, Th

Room: 220 ABI

Instructors: Coordinator: Carole Cramer, 102 ABI, 972-2025, [email protected]

Dr. Jay Xu, 313 ABI, 680-4812, [email protected]

Dr. Vipin Nair, 263 ABI, 680-4362, [email protected]

Dr. Ganapathy Sivakumar, 302 ABI, 680-4809, [email protected]

Dr. Walter Suza, 334 ABI, 680,4323 [email protected]


of their own primary research interests by examining five different areas in

depth. It will be assumed that students have a basic biochemistry,

genetics, molecular or cell biology background. The course will focus on a

discussion of papers. The experimental design, methodology, and conclusions

reached in the papers will be critically analyzed.

Text: There is no text; readings will consist of assigned journal articles (to be

arranged by the instructors). All journal articles will be posted on Blackboard.

It is the student’s responsibility to access all reading materials through

Blackboard.

Grades: The focus of this course will be in-class discussion of assigned papers.

Therefore, participation in the discussions will constitute the major portion of

the grading. In addition, there will be written exams (either take-home or in

class at instructors discretion). Each of the five sections is worth 20 points

(each section consisting of 12 points for in-class discussion and 8 points for

the written exam) for a total of 100 points. There is no final exam. If an

instructor selects to alter the distribution of points (discussion versus exam),

this change will be provided in writing to the students at the beginning of that

instructor’s section.

Discussion 60 points


Total: 100 points








Procedure for Approval of New Courses The role of the program committee is to work with the director in developing the curriculum. Changes to the curriculum once approved by the department and chair will be presented to the college graduate curriculum committee. The role of the college graduate committee is to evaluate proposed changes submitted by the departmental and program committees and recommend curriculum changes to the dean. The dean has the responsibility of approving or disapproving recommendations forwarded to by the college graduate curriculum committee. Changes pertaining to graduate curriculum will be sent to the Graduate Council (GC). The GC will evaluate proposed changes and make a recommendation to the VCAAR. Regular courses may not be taught until they have been published in the University bulletins. Special courses and non-degree credit courses may be taught without inclusion in the bulletins if assigned a special course number and approved by the GC and the Vice Chancellor for Academic Affairs and Research. Such courses may be repeated upon approval of the Vice Chancellor for Academic Affairs and Research. (excerpted from the ASU Faculty Handbook. Language adapted to fit this program).

Appendix D

Faculty Productivity

Funding (since 2006, or date of hire) of MBS “Core Faculty” Savary Arkansas Biosciences Institute, Protein Chemistry and Enzyme Systems Useful in Health and

Agriculture; B Savary PI, $200,000 (October 2006 through June 30, 2009). USDA-CSREES NRI, Mapping pectin nano-structure and functionality and modeling enzyme

action and properties; B Savary, co-PI, $96,000 to lab (October 2008 to September 2010). USDOE Mid-South/Southeast Biofuels Consortium, Biochemical technologies for generating

valuable co-products from biofuel production; B Savary, co-PI, $157,000 (Sept. 1 2008 to Aug. 31, 2009).

A Grippo NSF EPSCOR P3 (A Grippo; Co-I/Devareddy, PI)($107,964) 2009-2010 NSF GK-12 Proposal (A Grippo Co-I/Christian, PI) ($445,082) R Johnson Arkansas Game and Fish Commission. Genetic analysis of Florida and largemouth basses of

southern Arkansas lakes using microsatellites. R Johnson, PI 8/1/08-present. $12,766. ASU Faculty Research Grant. Relationship of gene flow to geographic distance in two species

of polychaetes with different dispersal capabilities. R Johnson, PI 8/1/08-present. $6,000. Arkansas Game and Fish Commission. Genetic analysis of Florida and largemouth basses of

southern Arkansas lakes using microsatellites. R Johnson, PI 6/1/07-7/31/08. $25,200. Completed.

Arkansas Game and Fish Commission. Gene flow and genetic structuring of yellowcheek darters (Etheostoma moorei) in the Little Red River watershed. Completed. R Johnson, PI $5,665.

SURF/SILO Arkansas Department of Higher Education. Introduction of Florida largemouth bass in an Arkansas population of northern largemouth bass and the performance of bass with those alleles. R Johnson, Co-PI. 12/31/06-12/31/07. $3,900.

Phillips Metabolic engineering for rice nutritional Arkansas Biosciences Institute 07-01-03 to 06-30-09

PI: G.C. Phillips $330,000 Lorence Role of Ascorbate in Coordinating Growth and Senescence in Arabidopsis thaliana” Agency:

National Institute of Health (NIH), Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE), A Lorence (PI) $603,574.00 (01/01/06 – 04/30/10)

Unraveling Sedative Triterpene Synthesis in Galphimia glauca: Phytochemistry and Functional Genomics Join Forces” Agency: Faculty Research Fund, Arkansas State University A Lorence (PI) Award: $6,500.00 (07/01/06 – 12/31/08).

Collaborative Seed Grant: Mechanisms of Toxicity and Remediation of Superfund Environmental Toxicants” Agency: Arkansas Biosciences Institute, Arkansas State University A Lorence, F Medina-Bolivar and K Redeker (Co-PIs) Award: $57,336.00 (07/01/06 – 06/30/09).

Arabidopsis as a Tool to Assess Toxicity and Fate of Nanomaterials” Agency: Nanotechnology Center, UALR A Lorence (PI) Award: $25,000.00 (10/01/07 – 12/31/08).

Role of Ascorbate in Mitigating ER and Cellular Stress Associated with Transient and Stable Plant-Based Protein Production” Agency: NSF EPSCoR P3 Center Collaborative Seed Grant Program Overall Statewide Project headed by Carole Cramer (ASU), Steve Grace (UALR) and Kenneth Korth (UAF) A Lorence (PI, ASU), M Dolan (Co-PI, ASU), and V Srivastava (Co-PI, UAF) Award: $249,860.00 (05/15/08 – 11/14/09).

Intersection of Ascorbate Regulation, Jasmonate-Signaling, and Defense Against Hervibores in Plants” Agency: NSF EPSCoR P3 Center Collaborative Seed Grant Program Statewide

Project headed by Carole Cramer (ASU), Steve Grace (UALR) and Kenneth Korth (UAF) Fiona Goggin (Co-PI), and Argelia Lorence (Co-PI) Award: $249,978.00 (05/15/08 – 03//14/10).

TCE toxicity and remediation” Agency: Arkansas Biosciences Institute at the Arkansas Children’s Hospital Research Institute (ACHRI) A Lorence, F Medina-Bolivar and C. Cramer (Co-PIs ASU), K Gilbert (PI ACHRI) Award: $180,000.00 (08/01/08 – 06/30/10).

Acquisition of qRT-PCR and Electrophysiology Equipment” Agency: NIH, Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE) M Srivatsan (Co-PI), A Lorence (Co-PI) and R Buchanan (PI) Award: $65,400.00 (01/01/00-04/30/09).

Acquisition of New Equipment and Shared Facilities” Agency: NIH, Arkansas IDeA Network of Biomedical Research Excellence (Arkansas INBRE) R Buchanan (PI), M Srivatsan (Co-PI) and A Lorence (Co-PI) Award: $24,518.00 (01/01/08-04/30/08).

Developing an Immunotoxicology Center in Arkansas” Agency: Arkansas Biosciences Institute at the Arkansas Children’s Hospital Research Institute (ACHRI) K Gilbert (PI), S Blossom, and B Przybyla (ACHRI), N Pumford (University of Arkansas at Fayetteville), J Fuscoe (National Center for Toxicological Research), F Medina-Bolivar, K Redeker, and A Lorence (Arkansas State University). Award: $200,000.00 (07/01/07 – 06/30/08).

Study and Manipulation of the Vitamin C – Cell Wall Metabolic Network for the Development of Plants with Enhanced Nutritional and Agronomical Properties ”Agency: Arkansas Biosciences Institute A Lorence (PI) Award: $230,000.00 (08/01/05 – 06/30/08, set-up package).

Funding to attend “Workshop on HPTLC-MS”, October 9-11, 2006, Berlin, Germany Agencies: ASU Sponsored Research Assistance and ASU Research Foundation A Lorence (PI) Award: $2,000.00 (July - October 2006).

Huang PI: X. Huang (Co-PIs: C. Cramer, S. Jennings), Efficient Algorithms for Protein Structure

Prediction and Applications in RTB Binding Occupancy Determination, Supported by NSF ESPCoR P3, $229,791, 2008-2010.

Co-PI: X. Huang (PI: E. Hood), Determination of Factors Affecting High-Level Protein Accumulation in Transgenic Maize Seed, Supported by NSF ESPCoR P3, $150,000, 2009-2010.

Co-PI: X. Huang (PI: H. Wang, Other Co-PIs: S. Grace, N. Ali), Metabolomic and Genomics Empowered Platform for Phytochemical and Gene Network Discovery in Medicago Truncatula, Supported by NSF ESPCoR P3, $222,584, 2008-2010.

PI: X. Huang, NSF ESPCoR equipment funds for the Bioinformatics Lab at Arkansas Biosciences Institute (ABI) of Arkansas State University, $30,000, 2008-2009.

PI: X. Huang, College Support for Molecular Biosciences (MBS) Techniques Modules in Bioinformatics, College of Sciences and Mathematics, Arkansas State University, $7,000, 2008.

PI: X. Huang, NIH grant from IDeA Network of Biological Research Excellence (INBRE) Summer Research Fellowship, Efficient Algorithms for RNA/Protein Structure Prediction, $21,063 (including $2,500 Research Support, College of Sciences and Mathematics, Arkansas State University), 2007.

PI: X. Huang, NIH grant from IDeA Network of Biological Research Excellence (INBRE) Summer Research Fellowship, Efficient Algorithms for Protein Tertiary Structure Prediction, $18,563, 2006.

Srivatsan 2008-2010 Co-PI on NSF EPSCoR grant proposal to develop infrastructure for Wireless,

Nano, Bio, Neuro sensors. Direct cost for neurosensor research $ 748,000

2006-2009 P.I. on NIH/NIDA R15 “Nicotine and development of autonomic neurons”. Direct cost, $150,000.

P.I. on NIH/NCRR INBRE“Cholinergic mechanisms in neuroregeneration”. Direct cost, $362,000.

Faculty development award, P.I. on nano material and neurotoxicity. Direct cost, $4,500. Xu EPSCoR NSF, Immunology lab start-up Xu, PI, $150,000 (August, 2008--May, 2009) ASU ABI Laboratory Startup Funding, Xu, PI $50,000 (June, 2009--May, 2010) Delta Center for Identity Solutions--ASU; PI--Hood; co-PI—Moeeni, AR Science and Technology

Authority. $150,000 10/1/06-6/30-09 Hood Ethanol from Agriculture for Arkansas and America Dept. of Energy, Walton Family Foundation

and Walmart Foundation; PI--Hood. $1,845,000, 7/1/08-12/31/09 Determination of Factors Affecting High-Level Protein Accumulation in corn EPSCoR P3

subaward—NSF,PI Hood $150,000 4/1/09-4/30/10 Crop Deregulation with Software: a Prototype, EPSCOR P3 subaward—NSF D. Berlean, PI, E.

Hood and R. Segall, co-PIs, $91,571, 5/1/09-5/31/2010 “Molecular technology in food microbiology III” Ahn, PI, Arkansas Biosciences Institute,

$17,385.60, July 2008 – June 2009. Buchanan PI R Buchanan, Co-PIs C Miller and M Dolan “Biotech in A Box” Arkansas Department of Higher

Education Grant Competition - FY2009 No Child Left Behind: Improving Teacher Quality: P-16 Education Partnerships, $102,000

PIs R Buchanan, M Srivatsan and A Lorence, INBRE equipment “INBRE Equipment Proposal qRT-PCR and Electrophysiology”, $65,400

PI R Buchanan, Co-PI A Hayar. “Novel treatment for smoking dependence and relapse”. AR ABI Collaborative Project Grant, $74,500

PI S Blossom, R Buchanan and M Dolan. ”Maternal smoking and neuroimmune modulation involving altered expression of nicotine sensitive acetylcholine receptors in the developing brain and immune system”. AR ABI Collaborative Project Grant, $60,000

PI Buchanan, Roger PI, ABI summer student research fellowships. ASU ABI, $13,400 PI Buchanan, Roger, A Biris, Dolan, Maureen and Medrano, Giuliana Co-PIs. “Characterization

of Absorption and Clearance of Inhaled Carbon Nanotubes Arkansas BioSciences Institute Seed Grant, $9,200

PI Buchanan, Roger Boulden, Jennifer CoI “Supplement to URM RISE-UP to fund Minority High School Student Research Fellows”. NSF DBI 01731603 (Suppl), $12,450

Effects of Nicotine on Processes Mediated by the Reticular Activating System” (through 4/30/09) L Cornett, PI; R Buchanan, PL NIH through the IDeA Networks of Biomedical Research (NIH-INBRE), NCRR 1P20-RR022058, $690,000

Buchanan, Roger PI, Standoff Hazardous Agent Detection and Evaluation System” DOD, $2,000,000

Buchanan, Roger PI, 2008 Research Support for International Graduate Students. ASU, $1,600 Buchanan, Roger PI Upgrade for HPLC. ASU OORTT, $5,300 Buchanan, Roger, Lorence Argelia, Srivatsan, Malathi PIs “Acquisition of New Equipment for

Shared Facilities”. AR , $24,518

Buchanan, Roger PI. “ABSORPTION, ACCUMULATION AND EXCRETION OF NANOPARTICLES BY LIVING ANIMALS” UALR Nanotechnology Center. $23,600

Buchanan, Roger PI , A Grippo, Co-PI..NSF URM NSF DBI 01731603 “URM: Cross disciplinary research at the interface of biotechnology and the environment., $309,863

Buchanan, Roger PI, ABI equipment grant, $10,800 Buchanan, Roger PI (through 6-30-070 ABI Undergraduate, $19,720 Buchanan, Roger PI (through 8/31/07) Honors Summer Undergraduate Research Internship in

Biotechnology, $ 5,000 Buchanan, Roger Co-PI (through 5/31/08), RAHSS (Supplement to NSF REU), $12,000 Buchanan, Roger PI (through 06/30/08) “Effects of In Utero Exposure to a Novel Chelator” R

Buchanan, PI Affinity Labeling Technologies, $17,688 Buchanan, Roger PI (through 03/31/08) “Effects Of Novel Chelator On Mercury Fate And

Distribution” R Buchanan, PI, Affinity Labeling Technologies, $40,230 Cramer Plant Transgenics for Vaccines, Adjuvants and Therapeutics, PI Cramer,CoPI M Dolan, ARK

Biosciences Inst., $110,400, 7/1/08 to 6/30/09 RII: Arkansas ASSET Initiative, *Cramer leads “Plant-Powered Production” Center, one of two

multi-institutional projects supported. PI McClure (ASTA), PI Cramer “Plant-Powered Production” (ASU), PI Varadan (UofA, $9M (plus $4.5M state match), 8/14/07 to 8/14/10

Phase II: Plant-based Bioproduction of Chicken Il-12 Adjuvant for Bird Flu Vaccine, PIs Radin, Cramer, USDA SBIR Phase II to BioStrategies LC, $350,000, 9/1/08 to 8/31/10

Efficient Algorithms for Protein Structure Prediction and Applications in RTB Binding Occupancy Determination , PI Huang, Co-PI Cramer, Co-PI Jennings, EPSCoR P3 Collaborative Grant, $229,791. 5/15/08 to 3/15/10

Dolan “Plant Transgenics for Vaccines, Adjuvants and Therapeutics”, Arkansas Biosciences Institute

(ABI 5-45031) C.L. Cramer (PI), M. Dolan (Co-PI) 7/1/07– 6/30/09 $ 110,400 Plant-based Bioproduction and the Arkansas P3 (Plant-Powered Production) Center NSF

EPSCoR ASSET Project 2: C.L. Cramer (PI), M Dolan Co-PI $1,900,000; 9/15/07-6/30/08 “Linking Plant-based Bioproduction to Multi-Institutional K-14 Science Outreach”NSF-EPSCoR

P3/Outreach subaward 8/1/08-7/31/09, $9,024. Role: Interim Outreach Coordinator “Role of Ascorbate in mitigating ER and cellular stress associated with transient and stable

plant-based protein production” NSF EPSCoR P3, PI A. Lorence, Co-PIs M. Dolan, V. Srivastava. 5/16/08-11/15/09 $249,860

“Regulation, production and purification of bioactive stilbenoids from hairy root cultures of peanut” NSF EPSCoR P3 F. PI Medina-Bolivar, Co-PIsJ. Carrier, M. Dolan, 5/16/08-11/15/09 $248,250.

“Plant-based Bioproduction of Chicken Il-12 Adjuvant for Bird Flu Vaccine”,. USDA SBIR Phase II, D. Radin (PI) ASU Subcontract: PI C. Cramer & Co-PI M. Dolan 9/1/08–8/31/10, $350,000 (ASU Subcontract $119,347)

“Maternal smoking and neuroimmune modulation involving altered expression of nicotine sensitive acetylcholine receptors in developing brain and immune system Arkansas Biosciences Institute Seed Grant, PIs: R. Buchanan, M. Dolan, Sarah Blossom, 12/1/08–11/31/10, $60,000

“ASU’s CSI Summer Camp – Attracting Young Investigators to Science and Technology through Crime Scene Investigation” Arkansas Science & Technology Authority CL Cramer (PI) coPIs: MC Dolan, E Benjamin, and C Dowling 5/16/08–12/16/08, $10,000

“Plant-based Bioproduction of Chicken Il-12 Adjuvant for Bird Flu Vaccine” USDA SBIR Phase I 2007-33610-17978 D. Radin (PI) ASU Subcontract: C. Cramer (PI) and M. Dolan (Co-PI), 7/1/07 – 2/28/08,$79,875 (ASU subcontract: $26,619).

“Species Authentication of Catfish Using Protein and DNA Based Diagnostics” USDA SBIR Phase II APL Science; LeeAnn Applewhite (PI), S. Bennett (PI); M. Dolan (coPI), 09/04 – 08/06, $296,000

Medina-Bolivar “Metabolic engineering for the overproduction of medicinal phytochemicals”, Medina-Bolivar, F.

(PI), Arkansas Biosciences Institute, $ 200,000, 07/01/05-6/30/08 “Effects of resveratrol-containing extracts from peanut hairy roots on human leukemia cells”,

Medina-Bolivar, F. (PI), Grippo, A. “Effects of resveratrol-containing extracts from peanut hairy roots on human leukemia cells”, Arkansas State University, Undergraduate Research Proposal. $ 1,000, 07/01/06-12/31/06

“Advanced training in HPTLC techniques for phytochemical analyses”, Medina-Bolivar, F. (PI) Arkansas State University/Eleanor Lane Travel Award, $ 750. Sep 2006

“Collaborative Seed Grant: Mechanisms of Toxicity and Remediation of Superfund Environmental Toxicants”, Lorence, A., Medina-Bolivar, F. (Co-PI), Redeker, K., Arkansas Biosciences Institute at Arkansas State University, $ 34,500, 07/01/06-06/30/08

“Development of Transgenic Sorghum Root Cultures for Production of Herbicides”, Medina-Bolivar, F. (PI), Arkansas State University, $ 7,000, 07/01/06-06/30/07

“Developing an immunotoxicology center in Arkansas”, Gilbert, K (AR Children’s Hospital Research Institute), Blossom S, Przyyla B, Pumford N, Fuscoe J, Medina-Bolivar F, Redeker K, Lorence A, Arkansas Biosciences Institute at Arkansas Children’s Hospital Research Institute, $ 200,000 (Note: funding provided to AR Children’s Hospital Res. Inst.), 07/01/07-06/30/08

“Scutellaria as a medicinal crop: Cryopreservation, hairy root culture, organic farming and anticancer activity”, Nirmal, J. (Fort Valley State Univ.), Prahlad, P. (Karmanos Cancer Inst. at Wayne State Univ.), Medina-Bolivar, F. (Co-PI, ASU), Shannon, D. (Auburn Univ.), Ellis, B. (USDA), Rimando (USDA), United States Department of Agriculture (USDA), Cooperative State Research, Education and Extension Service (CSREES), 1890 Capacity Building Grant, National Competitive Proposal, $ 434,258, 10/01/08-09/30/11

“Regulation, production and purification of bioactive stilbenoids from hairy root cultures of peanut”, Medina-Bolivar, F. (PI), Carrier, J. (Univ. of Arkansas, Fayetteville), Dolan, M. , National Science Foundation, EPSCoR-P3 Center for Plant-Powered Production Competitive Proposal, $ 248,250, 05/16/08-11/15/09

“Phytoremediation of trichloroethylene”, Gilbert, K., Lorence, A., Medina-Bolivar, F. (Co-PI), Cramer, C.,Arkansas Children’s Hospital Research Institute, $ 180,000, 07/01/08-06/30/10

“Enhancing abiotic stress tolerance and production of antioxidant in plants for Advanced Life Support in Space Exploration”. Khodakovskaya, M. (PI, UALR); Medina-Bolivar, F. (Co-PI, ASU). Arkansas Space Grant Consortium, $ 45,000, 04/15/08-4/14/11

“Regulation of secondary metabolism in tomato by genetic manipulation of the phosphoinositol pathway”. Khodakovskaya, M. (PI, UALR); Grace, S. (Co-PI, UALR); Ali, N. (Co-PI, UALR); Medina-Bolivar, F. (Co-PI, ASU). NSF-EPSCoR P3, $ 149,928

Weathers Proposal to develop algal biofuels. DOE Weathers (PI on grant to ASU in Arkansas), 9/1/08-

8/31/09, $200,000 PI on this segment of the overall ASU biofuels. Funding (since 2006, or date of hire) of MBS “Associated Faculty”

McKay Yanowitz, K. S. Vanderpool, T. McKay and A. Ross. 2006. CSI: Arkansas. National Science

Foundation 04-611 ITEST program, provide training to teachers and students on STEM careers and information technology. October 1, 2006-September 30, 2009. $1,006,800

McKay, T. and D. Gilmore. 2006. Survival of experimentally introduced bacteria in the house fly, usca domestica L. Research Faculty Award, Arkansas State University. July 1, 2006 – June 30, 2007. $4,845.

McKay, T. and A. D. Christian. 2006. Macroinvertebrate Biodiversity. 2005-2006 No Child Left Behind Program from the U.S. Department of Education. Arkansas Department of Higher Education. $27,753.

Bednarz, J.C., B. L. Noel and T. McKay. 2007. The breeding and foraging ecology of Pileated Woodpeckers in the bottomland forests and swamps of eastern Arkansas with reference to the conservation of the Ivory-billed Woodpecker. U. S. Department of the Interior Fish and Wildlife Service. – July 2008. $113,000.

Wilson, L. T., Y. Yang, F. H. Arthur, James Campbell, T. Siebenmorgan, J.-F. Meullenet, B. Adam, T. E. Reagan and T. McKay. 2007. Integrated post-harvest rice management and information delivery: optimizing insect control and grain quality. United States Department of Agriculture Cooperative State Research Education and Extension Service-Risk Avoidance and Mitigation Program. October 2007-2010. $612,199.

McKay, T. and D. Gilmore. 2006. Survival of experimentally introduced bacteria in the house fly, Musca domestica L. Research Faculty Award, Arkansas State University. July 1, 2006 –June 30, 2007. $4,845.

McKay, T. 2008. Survey of mosquito vectors of dog heartworm. Novartis, Sept 2008-Sept. 2009. $68,000.

McKay, T. 2008. Molecular diagnostics of mosquitoes. Arkansas Biosciences Institute. July 2008 – June 2009. $15,000.

Benjamin E Benjamin, PI, Arkansas Louis Stokes Alliance for Minority Participation (Arkansas State

University). National Science Foundation. $606,520.00 (2008-2011) E Benjamin, PI, Faculty Research Grant - Arkansas State University "The Microwave Synthesis

and Testing of Novel Antimicrobial Agents containing Cyclic Imidies" $5,464.80. (2008-2009)

E Benjamin, Co-PI, ASU’s CSI Summer Camp – Attracting Young Investigators to Science and Technology through Crime Scene Investigation. Arkansas Science & Technology Authority and Winthrop Rockefeller Foundation. $14,726.80 (2008)

Risch Risch, T.S. Mist-Netting Surveys for Endangered Bats. US Forest Service, Ozark-Saint Francis

National Forest. 2008. $50,000 Risch, T.S. A mist-survey of bats in the Donaldson Point Conservation Area with emphasis on

potential roost trees. Missouri Department of Conservation. 2008. $6,000. Risch, T.S. Are Brighter Bluebirds More Defensive? Surf Undergraduate Research Fellowship.

2008. $2,650. Risch, T.S. Mist-Netting Surveys for Endangered Bats. US Forest Service, Ozark-Saint Francis

National Forest. 2007. $41,500.

Risch, T.S. ASU Bluebird Project – Focusing on Education, Conservation and Ecological Research. Arkansas State University. Scholarly Activity Initiative Fund. 2007-2008. $3,000

Risch, T. S. Watchable Wildlife, AGFC/ASU Bluebird Project. Arkansas Game and Fish Commission. 2007-2008. $5,000.

Risch, T. S. Arkansas State University Bluebird Project. Kays Foundation. 2007-2008. $9,022. Risch, T.S. Home Range, Dispersal, and Survival of the Ozark Pocket Gopher. Arkansas Game

and Fish Commission. 2006-2009. $59,794. Risch, T.S. Roosting Ecology of Male Indiana Bats. Arkansas Game and Fish Commission.

2003-2006. $12,000. Risch, T.S. Ecology of Male Indiana Bats During the Swarming Period. US Forest Service,

Ozark-Saint Francis National Forest. 2003-2007. $36,500. Risch, T.S. Response of Wildlife Habitat to Prescribed Burning. US Forest Service, Ouachita

National Forest. 2003-2007. $24,190 Risch T.S. Distribution and Abundance of the Rafinesque Big Eared Bat and Southeastern Bat

in the Mississippi Delta and Gulf Coastal Plain of Arkansas. Arkansas Game and Fish Commission. 2004-2007. $50,000.

Risch, T.S. Assessing Roost Habitat Conditions for Three Endangered Bat Species Buffalo National River, Arkansas. National Park Service. $16,000. 2004-2007.

Pearce Pearce, A.R., & Biondolillo, K.D. (2007-2008). Oral nicotine and multiple bottle methods,

summer research grant funded by ASU-ABI $35,196 Pearce, A.R., & Biondolillo, K.D. (2006-2007). Environmental influences on the consumption of

oral nicotine, summer research grant funded by ASU-ABI $24,850. Pearce, A.R. (2005-2006). Establishing oral nicotine as a valid means of investigating

selfadministration. summer research grant funded by ASU-ABI, $13,295. Cramer, C., Biondolillo, K.D., Dolan, M., Pearce, A.R., Srivatsan, M. (2005-2006). Novel

strategies for developing effective nicotine vaccines for prevention or treatment of nicotine addiction, summer research grant funded by ASU-ABI, $19,369.

Peer-Reviewed Publications, Patent Applications and Book Chapters Authored by MBS “Core Faculty” since 2006 (or date of hire)

Savary Yoo, S.-H., B.-H. Lee, B.J Savary, A.T. Hotchkiss. Characteristics of PME-deesterified pectin gels

produced in the presence of monovalent ionic salts. J. Agric. Food Chem. (Submitted 2008.) Savary, B.J., Prasanna V., A. Nuñez, R.G. Cameron. Identification of thermolabile pectin

methylesterases isolated from sweet orange fruit by mass spectrometry profiling. J. Agric. Food Chem. (Submitted 2008.)

Savary, B.J., R.G. Cameron, G.A. Luzio, Prasanna V., A. Nuñez, and T.G. McCollum. Thermally-tolerant pectin methylesterase. U.S. patent application 11/986,187, filed November 20, 2007. (Peer-reviewed manuscript in preparation for J. Agric. Food Chem. 2008.)

Hood Clough, RC, Beifuss, K, Lane, J, Pappu, K, Thompson, K, Bailey, MR, Delaney, DE, Harkey, R,

Drees, C, Howard, JA and Hood, EE. 2006 Recombinant manganese peroxidase from the white-rot fungus Phanerochaete chrysosporium is enzymatically active and accumulates to high levels in transgenic corn seed. Plant Biotechnology Journal 4:53-62

Hood, EE and Woodard, SL 2006 Commercialization of a Protein Product from Transgenic Maize, NABC Report 17: Agricultural Biotechnology: Beyond Food and Energy to Health and the Environment: 147-158.

Howard, JA and Hood, EE 2007 Methods for growing nonfood products in transgenic plants; Crop Science; 47:1255-1262.

Hood, EE, Love, R, Bray, J, Lane, J, Clough, RC, Pappu, K Drees, C, Hood, KR, Yoon, S, Ahmad, A and Howard, JA; 2007 Subcellular targeting is a key condition for high-level accumulation of cellulase protein in transgenic maize seed. Plant Biotechnology J; 5:709-719

Hood, E.E. and J.A. Howard; 2008; “Over-expression of Novel Proteins in Maize” In: A. Kriz and B. Larkins, Eds., Molecular Genetic Approaches to Maize Improvement Springer—Berlin, Heidelberg, Germany pp. 91-105

A Grippo Brown, CE, S Trauth, RS Grippo, BJ Gurley, AA Grippo. 2008. Combined effects of ephedrine-

containing dietary supplements, caffeine, and nicotine on morphology and ultrastructure of rat hearts. Tox. Sciences (submitted for review)

Grippo, AA, K Capps, B Rougeau, BJ Gurley. 2007. Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplements. Ann. Pharmacother. 41:1375-82.

Grippo, AA, B Hamilton, R Hannigan, BJ Gurley. 2006. Metal content of ephedra-containing dietary supplements and other select botanicals. Am. J. Health Syst. Pharm. 63:635-644.

Johnson B. Kaimal, R.L. Johnson, and R. Hannigan. 2009. Distinguishing breeding populations of mallards

(Anas platyrhynchos) using trace elements. Journal of Geochemical Exploration (in press). R.L. Johnson, A.D. Christian, S.D. Henry and S.W. Barkley. 2009. Distribution and ecology of black

basses (Micropterus) in the lower Eleven Point River, Arkansas. Southeastern Naturalist (in press).

R.L. Johnson and T. Kennon. 2008. Teaching population genetics and evolution in the biology classroom using Drosophila. American Biology Teacher (In press).

M.S. Wine, M. Weston and R.L. Johnson. 2008. Population dynamics and ecology of a species of darter endemic to Arkansas. Southeastern Naturalist 7:665-678.

S.D. Henry, S.W. Barkley, J.B. Koppelman and R.L. Johnson. 2008. Assessment of stocking success of walleye (Sander vitreus) in the Eleven Point River, Arkansas. North American Journal of Fisheries Management 28:1498-1505.

J B. Trauth, R.L. Johnson, and S. E. Trauth. 2007. Conservation implications of a morphometric comparison between the Illinois chorus frog (Pseudacris streckeri illinoensis) and Strecker=s

chorus frog (P. s. streckeri) (Anura: Hylidae) from Arkansas, Illinois, Missouri, Oklahoma, and Texas. Zootaxa 1589:23-32.

M.R. Weston and R.L. Johnson. 2007. Visible implant elastomer as a tool for marking Etheostomine darters (Actinopterygii: Percidae). Southeastern Naturalist 7:159-164.

R. L. Johnson, S.M. Coghlan and T. Harmon. 2007. Spatial and temporal variation in prey selection of brown trout in a cold Arkansas tailwater. Ecology of Freshwater Fish 16:373-384.

R. L. Johnson, S. C. Blumenshine S. M. Coghlan. 2006. A bioenergetic analysis of factors limiting brown trout growth in an Ozark tailwater river. Environmental Biology of Fishes 77:121-132.

R.L. Johnson, R.M. Mitchell, and G.L. Harp. 2006. Genetic variation and genetic structuring of a numerically declining species of darter, Etheostoma moorei Raney & Suttkus, endemic to the Upper Little Red River, Arkansas. American Midland Naturalist 156:37-44.

Phillips Dabul, A.N.G., H. Belefant-Miller, M. RoyChowdhury, J.F. Hubstenberger, A. Lorence, and G.C.

Phillips. 2008. Screening of a broad range of rice (Oryza sativa L.) germplasm for in vitro rapid plant regeneration and development of an early prediction system. In Vitro Cell. Devel. Biol. – Plant 44 (In press).

Armah, P., A. Archer, and G.C. Phillips. 2009. Drivers leading to higher food prices: Biofuels are not the main culprit. (Invited article) In Vitro Cell. Devel. Biology – Plant: Special Issue on Biofuels 45 (In press).

Lorence Book chapters A Lorence and CL Nessler (2007) Pathway engineering of the plant vitamin C metabolic network. In

“Applications of Plant Metabolic Engineering” R Verpoorte, AW Alfermann and TS Johnson (eds). Springer, Dordrecht, chapter 8, pp 197-217.

Peer-reviewed abstract Lisko KA*, Harris RS*, Yactayo-Chang J* and Lorence, A (2008) “Engineering ascorbate for

enhanced growth, nutritional content, and stress tolerance in crops” In Vitro Cellular and Developmental Biology Animal 44: S28.

Dabul ANG*, Belefant-Miller HB, RoyChowdhury M, Hubstenberger JF, Lorence A, and Phillips GC (2008) Screening of a broad range of rice (Oryza sativa L.) germplasm for in vitro rapid regeneration and development of an early prediction system. In Vitro Cellular and Developmental Biology – Plant, Vol. 44. Online November 21, 2008. DOI 10.1007/s11627-008-9174-6.

Schroeter C, House LA and Lorence A (2007) Fruits and Vegetable Consumption Among College Students in Arkansas and Florida: Food Culture vs. Health Knowledge. International Food and Agribusiness Management Review 10: 63-89.

Huang Parameterized complexity and biopolymer sequence comparison, L. Cai, X. Huang, C. Liu, F. A.

Rosamond, and Y. Song, The Computer Journal 51, 2008. Fixed-parameter approximation: conceptual framework and approximability results, L. Cai and X.

Huang, Algorithmica, 2008. A practical comparison of two K-means clustering algorithms, G. A. Wilkin and X. Huang, BMC

Bioinformatics 9(Suppl 6), 2008. Protein tertiary structure prediction by protein threading: a survey, X. Huang, L. Cai, and E. Hood, to

appear in Plant Biotechnology Journal, 2008. Efficient parameterized algorithms for biopolymer structure-sequence alignment, Y. Song, C. Liu, X.

Huang, R. L. Malmberg, Y. Xu, and L. Cai, IEEE/ACM Transactions on Computational Biology and Bioinformatics 3: 423-432, 2006.

Polynomial time approximation schemes and parameterized complexity, J. Chen, X. Huang, I. A. Kanj, G.Xia, Discrete Applied Mathematics 155: 180-193, 2007.

Strong computational lower bounds via parameterized complexity, J. Chen, X. Huang, I. A. Kanj, G. Xia, Journal of Computer and System Sciences 72: 1346-1367, 2006.

On the computational hardness based on linear FPT-reductions, J. Chen, X. Huang, I. A. Kanj, G. Xia, Journal of Combinatorial Optimization 11: 231-247, 2006.

Srivatsan Eric Duncan, Jonathan Treece and Malathi Srivatsan (2008) The expression of brain cholinesterases

change with age in fat head minnow (Pimephales promelas) Environmental toxicology and chemistry (submitted)

Jining Xie, Linfeng Chen, Vijay K Varadan, Justin Yancey and Malathi Srivatsan (2008) The effects of functional magnetic nanotubes with incorporated nerve growth factor in neuronal differentiation of PC12 cells Nanotechnology 19 105101-105108

Srivatsan, M. (2006) An analysis of acetylcholinesterase sequence for predicting mechanisms of its non-catalytic actions. Bioinformation, 1(8): 281-284

M. Srivatsan, J. Treece and E.E. Shotts (2006) : Nicotine alters nicotinic receptor subunit levels differently in developing mammalian sympathetic neurons. Ann N.Y.Acad. Sci. 1074: 505-513

Jining Xie, Linfeng Chen, Kiran R Aatre, M Srivatsan and V K Varadan (2006) Somatosensory neurons grown on functionalized carbon nanotube mats. Smart Materials and Structures, 15: N85-88.

Xu Nokyoung Park, Soong Ho Um, Hisakage Funabashi, Jianfeng Xu, Dan Luo. A Cell-free Protein

Producing Gel (Full Article). Nature Materials. In Press. Jianfeng Xu, Li Tan, Derek T. A. Lamport, Allan Showalter and Marcia J. Kieliszewski. Biochemical

characterization of hydroxyproline-rich glycoproteins expressed in Arabidopsis thaliana suspension cultured cells and proposed role of hydroxyprolyl-O-glycans in secretion. Phytochem. 2008, 69 (8): 1631-1640.

Jinafeng Xu. High-yield expression of therapeutic proteins with extended serum half-life in tobacco cells, Chin J Biotechnol. 2008.

Book chapter Wenlong Cheng, Liang Ding, Hisakage Funabashi, Nokyoung Park, Soong Ho Um, Jianfeng Xu, Dan

Luo, Nucleic Acid Engineering-Towards Synthetic Biology. In: Systems biology and synthetic biology. Wiley, March 2009.

Ahn “Campylobacter jejuni invade chicken LMH cells inefficiently and stimulate differential expression of

the chicken CXCLi1 and CXCLi2 cytokines”, C. L. Larson, D. H., Shah, A. S. Dhillon, D. R. Call, S. Ahn, G. J. Haldorson, C. Davitt, and M. E. Konkel, Microbiology, 2008. 154, 3835-3847.

“Detection of cholera toxin in seafood using a ganglioside-liposome immunoassay”, S. Ahn and R. A. Durst, Analytical and Bioanalytical Chemistry, 2008, 391, 473-478.

Buchanan Add Patent application Jennifer L. Bouldin, Taylor M. Ingle, Regina Alexander, Roger A. Buchanan, 2008 Absorption of

Semiconductor Nanocrystals by the Aquatic Invertebrate Ceriodaphnia dubia. Bulletin of Environmental Contamination and Toxicology 27(9):1958-1963.

Jennifer L. Bouldin, Taylor M. Ingle, Anindita Sengupta, Regina Alexander, Robyn E. Hannigan, Roger A. Buchanan, 2008. Aqueous toxicity and food chain transfer of quantum dots in freshwater algae and Ceriodaphnia dubia. Environmental Toxicology and Chemistry 81(3):249-252.

Akash Shah and Roger Buchanan, 2008. Localization of Nicotine-Sensitive Cells in the Brainstem. Journal for Young Investigators 18(2):47-52.

Ingle, Taylor; Hannigan, Robyn; Buchanan, Roger; and Bouldin, Jennifer. 2007. Detection, measurement and toxicology of semiconductor nanocrystals in Ceriodaphnia dubia. Proceedings of NSTI Nanotechnology 2007 2:612-616.

http://www.iop.org/EJ/search_author?query2=Malathi%20Srivatsan&searchfield2=authors&journaltype=all&datetype=all&sort=date_cover&submit=1



E. Garcia-Rill, R. Buchanan, K. McKeon, R.D. Skinner and T. Wallace, 2007. Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems. Neurotoxicology 28(5):915-923.

Edgar Garcia-Rill, Cameron H Good; Kevin D Bay; Roger Buchanan, Robert D Skinner. Muscarinic and nicotinic responses in the developing pedunculopontine nucleus (PPN), 2007. Brain Research 1129:147-155.

Smolinski TG, Boratyn GM, Milanova M, Buchanan R, and Prinz AA, 2006. Hybridization of Independent Component Analysis, Rough Sets, and Multi-Objective Evolutionary Algorithms for Classificatory Decomposition of Cortical Evoked Potentials. Proc. of the 2006 Workshop on Pattern Recognition in Bioinformatics 2006 (PRIB 2006), Lecture Notes in Bioinformatics 4146:174-183.

CH Good, KD Bay, RA Buchanan, KA McKeon, RD Skinner and E Garcia-Rill, 2006. Prenatal exposure to cigarette smoke affects the physiology of pedunculopontine neurons in development. Neurotoxicology and Teratology, 28(2):210-9.

Ingle T, Hannigan R, Buchanan R and J Bouldin, 2007. Detection, Measurement and Toxicology of Semiconductor Nanocrystals in Ceriodaphnia dubia. Proceedings of NSTI Nanotechnology 2007 2:612-616. (Peer-reviewed).

Smolinski, T.G., Buchanan, R., Boratyn, G.M., Milanova, M., and Prinz A.A., 2006. “Independent Component Analysis-Motivated Approach to Classificatory Decomposition of Cortical Evoked Potentials,” BMC Bioinformatics, 7 (Suppl 2):S8, 2006.

McMickle A and R Buchanan, 2006. Stop and Investigate (invited response to “Protocol Review”) Lab Animal 35(10):15-18.

Tomasz G. Smolinski, Mariofanna Milanova, Grzegorz M. Boratyn, Roger Buchanan, and Astrid A. Prinz, 2006. Multi-Objective Evolutionary Algorithms and Rough Sets for Decomposition and Analysis of Cortical Evoked Potentials. Proceedings of the IEEE International Conference on Granular Computing (GRC 2006) 2006:635-638.

Dolan Medrano, G., Reidy, M.J., Liu, J., Ayala, J., Dolan, M.C. and Cramer C.L. 2008 Rapid system for

evaluating bioproduction capacity of complex pharmaceutical proteins in plants. In: “Recombinant Proteins from plants”, L. Faye, and V. Gomord, eds. Methods and Protocols. Series: Methods in Molecular Biology. Humana Press, Totowa, NJ; 483:41-50.

Woffenden B.J., Ñopo L.H., Cramer C.L., Dolan M.C. and Medina-Bolivar, F. 2008. Expression of a ricin B:F1:V fusion protein in tobacco hairy roots: steps toward a novel pneumonic plague vaccine. . Electronic J Integrative Biosci. 3:10-19.

Liu, J., Dolan, M.C., Reidy, M., and Cramer, C.L.. 2008. Production of bioactive single-chain murine IL-12 in transgenic plants. J Interferon Cytokine Res 28(6):381-92.

Medina-Bolivar F., Condori J., Rimando A., Hubstenberger J., Shelton K., Bennett S., Dolan M.C. 2007. Production and secretion of resveratrol in hairy root cultures of peanut. Phytochemistry 68:1992-2003.

Cramer Cramer, C.L. 2007. Antigens and therapeutics – its all in the delivery, Internat. Conf. on Plant-Based

Vaccines and Antibodies (PBVA 2007), Univ. of Verona, Italy, June 18-20 2007. (Invited symp. speaker)

Cramer, C.L., M.J. Reidy and M.C. Dolan. 2007. Methods of delivery of molecules to cells using ricin subunit and compositions relating to same, US Provisional Patent 60/944193; pending; full filing 2008.

Liu, J., M.C. Dolan, M. Reidy, and C.L. Cramer. 2008. Expression of bioactive single-chain murine IL-12 in transgenic plants. J. Interferon Cytokine Res., 28:27–38.

Medrano, G., M.J. Reidy, J. Liu, J. Ayala, M.C. Dolan and C.L. Cramer. 2009. Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants. In Methods in

Biotechnology: Recombinant Proteins from Plants, L. Faye, V. Gomond, eds., Humana Press, USA, pp. 51-68.

Liu, C., M. Towler, G. Medrano, C. Cramer, P.J. Weathers. 2009. Production of mouse interleukin-12 is greater in tobacco hairy roots grown in a mist reactor than in an airlift reactor. Biotechnol. Bioeng.102:1074-1086.

Medina-Bolivar Medina-Bolivar F, Condori J, Rimando A, Hubstenberger J, Shelton K, Bennett S, Dolan M. 2007.

Production and secretion of resveratrol in hairy root cultures of peanut. Phytochemistry. 68:1992-2003.

Medina-Bolivar F, Nopo-Olazabal C, Nopo-Olazabal L, Sivakumar G, Condori J. 2007. Screening for bioactives stilbenes in the genus Nicotiana. Recent Advances in Tobacco Science. 33:93-100.

Pitta-Alvarez S, Medina-Bolivar F, Alvarez M, Scambatto A, Marconi P. 2008. In vitro shoot culture and antimicrobial activity of Berberis buxifolia Lam. In Vitro Cellular & Developmental Biology 44:502-507.

Sivakumar G, Christopher S, Medina-Bolivar F, Uccella N. 2008. Plant-based Small Molecules and Proteins: A Source for Natural Medicines. In: Plant Secondary Terpenoids. (in press).

Condori J, Medrano G, Sivakumar G, Nair V, Cramer C, Medina-Bolivar F. 2008. Functional characterization of a stilbene synthase gene using a transient expression in planta. Plant Cell Reports DOI 10.1007/s00299-008-0664-0.

Weathers Towler, M.J., Wyslouzil, B.E., Weathers, P.J. 2007 Using an aerosol deposition model to increase

hairy root growth in a mist reactor. Biotechnology & Bioengineering, 96:881-891. Wang, Y., Weathers, P.J. 2007 Sugars proportionately affect artemisinin production. Plant Cell

Reports. 26:1073-1081. Towler, MJ, Weathers PJ 2007 Evidence of artemisinin production from IPP stemming from both the

mevalonate and the nonmevalonate pathways. Plant Cell Reports 26:2129–2136. Sharaf-Eldin, MA, Elkholy S, Fernandez JA, Junge H, Cheetham RD, Guardiola JL, Weathers PJ

2007 The effect of Bacillus subtilis FZB24 on flower quantity and quality of saffron (Crocus sativus L.). Planta Medica 73: 1010-1011.

Sharaf-Eldin, MA, Elkholy S, Fernandez JA, Junge H, Cheetham RD, Guardiola JL, Weathers PJ 2008 Bacillus subtilis FZB24® Affects Flower Quantity and Quality of Saffron (Crocus sativus L.) Planta Medica, 74:1316-1320.

Weathers PJ, Towler M, Wang Y, Wobbe KK 2009 Artemisinin: controlling its production in Artemisia annua. In: Isoprenoid synthesis in plants and microorganisms. TERPNET 2007. Ed. T. Bach, Springer publishing, NY, NY under review, INVITED CHAPTER.

Liu CZ, Towler MJ, Medrano G, Cramer CL, Weathers PJ 2009 Production of Mouse Interleukin-12 is Greater in Tobacco Hairy Roots Grown in a Mist Reactor than in an Airlift Reactor. Biotechnol Bioengin. 102:1074-1086.

Peer-Reviewed Publications and Book Chapters Authored by MBS “Associated Faculty” since

2006 (or date of hire) McKay McKay. T, C. D. Steelman, S. M. McElroy, and A. L. Szalanski. Sustained Mass Release of Pupal

Parasitoids (Hymenoptera: Pteromalidae) for Control of Hydrotaea aenescens and Musca domestica (Diptera: Muscidae) in Broiler-Breeder Poultry Houses in Arkansas. Journal of Agricultural and Urban Entomology. In Press.

McKay, T*. and T. Herman. 2008. Thermoregulation in three species of damselflies (Odonata: Lestidae), with notes on temporal distribution and microhabitat use. Odonatologica 37 (1): 29-39.

Milanovich, J. R., S. E. Trauth and T. McKay. 2008. Diet of the western slimy salamander Plethodon albagula (Caudata: Plethodontidae), from two mountain ranges in Arkansas. Southeastern Naturalist 7 (2): 323-330.

McKay, T*. and A. B. Broce. 2008. Host size and oviposition site effects on the sex ratio of the pupal parasitoid Muscidifurax zaraptor (Hymenoptera: Pteromalidae). Annals of the Entomological Society of America. 101 (3): 650-655.

Dry, F., D. C. Steinkraus, C. D. Steelman, R. W. McNew and T. McKay*. 2007. Survey of parasitoids (Hymenoptera: Pteromalidae) of house fly (Diptera: Muscidae) pupaefrom broiler-breeder poultry houses in Northwest Arkansas. Biocontrol Science and Technology. 17 (7): 757-763.

Benjamin Y. M. Hijji, E. Benjamin, E. Benjamin, R. J. Butcher and J. P. Jasinski. 3-(2,6-Dioxopiperidin-3-yl)-3-

azabicyclo[3.2.0]heptane-2,4-dione. Acta Cryst. 2009, E65, o394-o395. Aaron M. Lineberry, Ellis T. Benjamin, Raymond E. Davis, W. Scott Kassel, and Kraig A. Wheeler.

Structural Studies of Racemates and Quasiracemates: Chloro, Bromo, and Methyl Adducts of 2-Phenoxypropionic Acid. Crystal Growth & Design. 2008, 8, 612–619.

Ellis Benjamin, and Yousef Hijji. The Synthesis of Unsubstituted Cyclic Imides Using Hydroxylamine under Microwave Irradiation. Molecules. 2008, 13, 157-169.

Ellis Benjamin, Yousef M. Hijji. A Novel Microwave Synthesis of Unsubstituted Cyclic Imides. Published in the proceedings of ECSOC-11, The Eleventh International Electronic Conference on Synthetic Organic Chemistry, November 1-30, 2007. Editor: Julio A. Seijas & M. Pilar Vázquez Tato, ISBN 3-906980-19-7.

R. J. Butcher, J. P. Jasinski, E. Benjamin, Y. M. Hijji, E. Benjamin. 5-Hydroxy-4-methyl-4-azatricyclo[5.2.2.02,6]undec-8-en-3-one. Acta Cryst. 2007, E63, o4565.

Earl Benjamin III, Aron Reznik, Ellis Benjamin, Arthur L. Williams. Mathematical Models of Cobalt and Iron Ions Catalyzed Microwave Bacterial Deactivation. Int. J. Environ. Res. Public Health. 2007, 4(3), 203-210.

Earl Benjamin, Arron Reznik, Ellis Benjamin, Arthur L. Williams. Mathematical Model of Manganese Ion Catalyzed Deactivation of Enterococcus faecalis, Staphylococcus aureus, and Escherichia coli. Cellular and Molecular Biology. 2007, 53(3), 49-54.

Earl Benjamin, Arron Reznik, Ellis Benjamin, Arthur L. Williams. Mathematical Models for Conventional and Microwave Thermal Deactivation of Enterococcus faecalis, Staphylococcus aureus, and Escherichia coli. Cellular and Molecular Biology. 2007, 53(3), 42-48.

Ray J. Butcher, Yousef M. Hijji and Ellis Benjamin. 1-Methoxy-pyrrolidine-2,5-dione Acta Cryst. 2007, E63, o1502-o1503.

Ray J. Butcher, Yousef M. Hijji and Ellis Benjamin. 3-Aminocyclopent-2-en-1-one Acta Cryst. 2007, E63, o610–o612.

Yousef M. Hijji and Ellis Benjamin. Efficient Microwave Assisted Syntheses of Unsubstituted Cyclic Imides. Heterocycles. 2006, 68(11), p2259-2267.

Raymond J. Butcher, Yousef M. Hijji, and Ellis Benjamin. cis-3-Azabicyclo[3.2.0]heptane-2,4-dione. Acta Cryst. 2006, E62, o1266-o1268.

Risch Connior, M. B., and T. S. Risch. Benefits of subcutaneous implantation of radiotransmitters in pocket

gophers. Southwestern Naturalist (in press). Connior, M. B., I. Guenther, and T. S. Risch. Lampropeltis calligaster calligaster,(Prairie Kingsnake),

Prey. Herpetological Review (in press). Connior, M. B., and T. S. Risch. A simple, new live trap for pocket gophers. Southwestern Naturalist

(in press). Medlin, R. E. Jr, and T. S. Risch. 2008. Habitat associations of bottomland bats, with focus on the

Rafinesque big-eared bat and the southeastern myotis. American Midland Naturalist 160:400-412.

Fokidis, H. B. and T. S. Risch. 2008. Does gliding when pregnant select for larger females? Journal of Zoology 275:237-244.

Fokidis, H. B. and T. S. Risch. 2008. The burden of motherhood: gliding locomotion in mammals influences maternal reproductive. Journal of Mammal 89:617-625.

Risch, T. S., G. R. Michener, and F. S. Dobson. 2007. Variation in litter size: A test of hypotheses in Richardson’s ground squirrels. Ecology 88:306-314.

Fokidis, H. B., T. S. Risch, and T. C. Glenn. 2007. Reproductive and resource benefits of female body size in a mammal exhibiting female-biased sexual size dimorphism. Animal Behaviour 73:479-488.

Medlin, E. C. and T. S. Risch. 2006. Decoration or deterrent? An experimental test of snake skin use in artificial bird nests. Condor 108:963–965.

Fokidis H. B., C. Robertson, and T. S. Risch. 2006 Keeping tabs: are redundant marking systems needed for rodents? Wildlife Society Bulletin 34:764–771.

Risch, T. S. and T. J. Robinson. 2006. First observation of cavity nesting by a female Blue Grosbeak. Wilson Journal of Ornithology 118:107-108.

Pearce Pearce, A.R., *Ramsey, A., Chuikova, T., & Galyautdinova, S. (in press). A positive psychology

perspective on mate preferences in the United States and Russia (in press). Journal of Cross-Cultural Psychology

Biondolillo, K., Pearce, A.R., *Louder, M.C., & McMickle, A. (2009). Solution concentration influences voluntary consumption of nicotine under multiple bottle conditions. Pharmacology, Biochemistry & Behavior, 92,214-218.

Biondolillo, K.D., & Pearce, A.R. (2007). The influence of availability on voluntary selfadministration of oral nicotine by female rats, Neuropsychobiology, 55, 73-80.

Pearce, A.R., & *Cline, R.L. (2006). Teaching the Statistics Laboratory– keep up the PACE. American Journal of Psychological Research, 1, 1-7.

Eubank, L. E. (in press). A review of recent advances in deep brain and vagus nerve stimulation techniques, Journal of Psychological Inquiry

Appendix E

Equipment Inventory

Camera Coolsnap Photometrics LS3020 12 599 58$

Arkansas Biosciences Institute Total 4,799,319.93$ Room Cost

Microscope Te2000‐U Inverted Product LS3190 7,290.48$ System For Visible Light Analysis LS3020 12,343.38$ Refirgerator, Chromatography LS3020 2,672.77$ Refrigerator Chromatography AB3430 2,672.77$ Centrifuge,Thermo Iec Refrigerated LS3030 3,371.95$ Centrifuge, Hermle Refrigerated LS3020 5,595.34$ Incubator, Microprocessor AB3380 3,923.67$ Incubator, Microprocessor AB3380 3,923.67$ Vwr Balance 220g X 0.01mg LS3030 6,645.67$ Spectrophotometer, Vwr #Bl517941 LS3030 7,859.45$ Freezer,Thermo Forma Model 759 LS3230 5,297.52$ Saturn 2200 Gc/Ms With 3800 Gc, Turbo AB2064 80,159.46$ Spectrometer Fiber Optic System LS3040 3,060.78$ Deuterium‐Tungsten Halogen Light Source LS3040 5,704.67$ Table 63‐500 Series High‐Performance Lab LS4300 3,403.49$ Touchgene Gradient Thermal Cyclar LS4300 5,600.60$ Nikon Smz800 With Ixapo Lens LS4050 14,408.87$ Microscope, Nikon Eclipse 600 LS1440 20,670.57$ Camera, Roper Fx Monochrome AB2058 5,726.75$ Camera Coolsnap Photometrics, LS3020 12 599 58$ , . Metamorph Basic Offline Package LS3200 3,414.00$ Camera,Nikon Dxm1200 Digital LS1440 7,329.91$ Pulverizer, Vibratory Ring LS1200 16,625.65$ Chromatography (Hplc) Liquid AB2064 25,224.28$ Thermal Cyclar, Touchgene Gradient LS3030 7,277.34$ Computer, Dell P4 Latitude C840 AB2007 2,984.25$ Computer, Dell P4 Inspiron 8200 AB101B 3,557.75$ Computer, Dell P4 Inspiron 8200 WL4090 3,557.75$ Computer, Dell Pr Inspiron 8200 BB332A 2,856.25$ Computer, Dell P4 Precision M50 AB2062 3,342.73$ Computer, Dell P4 Inspiron 8200 AB101B 2,508.87$ Radial Maze (8‐Arm) For Rats AB2061 17,761.00$ Computer, Dell P4 Inspiron 8500 AB1140 4,112.46$ Computer, Dell P4 Precision 350 AB0000 2,676.10$ Absorption Cell Astigmatic Multiple LS5430 17,106.53$ Computer, Dell P4 Inspiron 8500 AB1230 3,120.28$ Low Speed Saw,Isomet LS3390 4,319.30$ Laser, Cetac Lsx‐500 AB2059 92,560.00$ Multi‐Gauge Unit, Varian Inc.‐Basic LS5430 4,228.68$ Tandberg 1000 Presenter Package LB0000 8,881.55$ Tandberg 1000 Presenter Package LB0000 8,881.55$ Cryostat‐Deluxe Vibratone Ultrapro AB2062 22,120.99$ Osmosis System, Diamond Ro AB2062 8,114.25$ Osmosis System, Diamond Reverse AB2043 3,517.16$

Bench Labconco AB2046 $

Stereotaxic 4 Manipulator AB2062 8,750.00$ Camera, Nikon D100 Digital AB2050 18,332.70$ Balance, Proflevel Pr503 AB2062 4,487.37$ Computer, Apple G‐4 AB2063 2,877.38$ Laser, Multi‐Diode LS5430 3,760.65$ Analysis System, Dataquest LS3380 31,965.32$ Biopotential Pressure LS3380 4,938.31$ Vibratome 1500 AB2062 7,472.88$ Liquid Reinforcement System (Operant) AB2061 2,848.43$ Digidata 1322a. AB2058 6,357.50$ Axoclamp‐2b 2 Electrode Voltage AB2058 12,139.38$ Purifier Clean Bench Labconco AB3560 6,547.00$ Electron Microscope, Vega Model 5136xm LS1480 157,001.63$ Edx System, Inca Energy 200 LS1480 42,312.81$ Dual Coater System, Cressington 108 LS1480 10,515.19$ Electron Detector, Vega Tescan LS0001 14,404.69$ Oscilloscope, Digital Storage AB2058 3,069.09$ Copier, Toshiba E‐Studio 550 AB3000 9,458.69$ Analyzer, Em‐Scan Model Sa‐3000 LS3040 4,149.88$ Detection Chamber Em‐Scan Sa‐3057 LS3040 4,113.08$ Smoking Machine, Cigarette AB1160 18,128.94$ Purifier,Clean Bench LabconcoPurifier,Clean AB2046 8,133.81$ 8,133.81Thermal Cycler, Icycler AB3620 54,610.93$ Laser, Multi‐Diode LS5430 3,760.65$ Purification System, Water, Barnstead LS5430 3,042.68$ Ultracentrifuge, Optima L‐90x AB2038 50,519.71$ Micromanipulator, Narishige Mp‐2 AB2062 3,046.06$ Micromanipulator, Narishige Mp‐2 AB2063 3,046.06$ Stimulator, Dual Nerve And Muscle AB2063 5,286.84$ Routine Peltier Sys. (Spectrophotometer) AB3440 14,415.02$ Conferencing System, Imprint Systems LB0002 48,153.10$ Centrifuge, Allegra Beckman Coulter AB2058 6,620.31$ Centrifuge, Allegra Beckman Coulter AB2044 10,532.22$ Laboratory Autoclave AB3440 10,327.34$ Microscope, Nikon Smz‐1500 AB2050 15,149.59$ Microplate Reader, Stat Fax 2100 Elisa AG2450 4,155.13$ Chromatograph, Perkin Elmer Clarus AB2053 172,681.10$ Spectrometer, Elan Drc Ii AB2063 92,672.48$ Spectrophotometer, Spectronic Genesys AB2053 4,271.82$ Coolsnap Fx Hq Photometrics LS3190 37,213.27$ Crematory, Therm Tec G‐8‐P Animal EN1000 36,745.98$ Laboratory Autoclave LS3190 7,029.55$ Refrigerator, Chromatography AB2062 3,030.29$ Chromatograph, Perkin‐Elmer Clarus AB2063 72,967.33$ Vacuum Oven, Vwr Model 1430m AB2055 2,907.07$ Vacuum Oven, Vwr Model 1430m AB2040 2,907.07$ Vacuum Oven, Vwr Model 1430m AB2034 2,907.07$

Flow Clean AB3510 $

Vacuum Oven, Vwr Model 1430m AB3610 2,907.07$ Vacuum Oven, Vwr Model 1430m AB3530 2,907.07$ Vacuum Oven, Vwr Model 1430m AB3460 2,907.07$ Ventilated Cabinets For Animal Research AB2059 11,164.36$ Microscope, Nikon E600 AB0000 47,312.79$ Microscope, Nikon Eclipse E800 AB2047 233,148.95$ Distruptor, Microson Xl2000 Ultrasonic LS3020 3,115.93$ Growth Chambers Conviron Atc60 AB1400 34,968.32$ Growth Chambers Conviron Atc60 AB1400 34,968.32$ Growth Chamber Conviron Atc60 AB1400 34,968.32$ Growth Chamber Conviron Atc60 AB1400 34,968.32$ Growth Chamber Conviron Atc40 AB1400 34,968.32$ Growth Chamber Conviron Atc40 AB1400 34,968.32$ Growth Chamber Conviron Pgc20 AB1400 36,841.65$ Growth Chamber Conviron Pgc20 AB1400 36,841.65$ Growth Chamber Conviron Pgc20 AB1400 36,841.65$ Growth Chamber Conviron Pgc20 AB1400 36,841.65$ Spm Control Station, Nanoscope Iv, Veeco LS1480 106,527.96$ Microscope, Scanning Probe, Veeco LS1480 61,663.76$ Scanner, Veece, 125 Um Afm For Mmafm LS1480 10,097.85$ Microscope, Veeco Omv‐Ntsc Video Only LS1480 6,362.76$ Flow Clean Bench, Edgegard Eg6252Bench, Edgegard Eg6252 AB3510 7,152.25$ 7,152.25Flow Clean Bench, Edgegard 6320 AB3510 7,821.37$ Freezer, Ultralow ‐86c Upright AB2058 8,119.40$ Freezer, Sanyo Model #Mdf‐792c. AB2038 8,891.84$ Lock‐In Amplifier, Model Sr‐510 LS5430 5,009.35$ Biopotential, Temp & Physical Activity LS3380 3,671.88$ Biopotential, Temp & Physical Activity LS3380 2,678.13$ Centrifuge, Model 58 10r, Refrigerated LS3380 6,807.50$ Microplate Washer, Sargent‐Welch AB3020 5,548.81$ Robocycler 96 LS3550 7,126.83$ Robocycler 96 LS3550 7,126.82$ Locator Jr. W/Level Monitor Csa AB3500 3,103.60$ Transmitter, Tl11m2‐C50‐Pxt LS3380 3,083.40$ Headspace Sampler, Turbomatrix AB2059 19,330.55$ Computer, Dell Latitude D400 AB3160 2,931.23$ Anesthesia Center, Impac6 AB110A 7,936.40$ Anesthesia Center, Impac6 AB110A 7,936.40$ Konica Srx 101a Processor AB2031 4,767.00$ Konica Srx 101a Processor AB3310 4,767.00$ Autoclave, Tabletop Tuttnauer/Brinkman AB2061 4,111.92$ Kodak Image Station 440cf System AB2052 20,204.85$ Refrigerator, Chromatography AB3540 2,735.72$ Homogenizer, Brinkman Polytron AB3540 3,142.76$ Roller System, Cellr Oll Modular And AB2046 2,951.67$ Freezer, Revo Value Upright Ultralow AB3580 5,718.86$ Sterilizer, Sterilmatic AB3430 7,221.76$

Carv Confocal AB2047 $

System, Bio‐Rad, Biologic Duoflo AB3540 46,342.11$ Versadoc 4000 Pc, Bio‐Rad System AB3540 44,564.70$ Imager, Personal Molecular Fx/Pc AB3540 36,195.15$ System, Pds‐1000/He, Hepta System LS1480 19,031.70$ Spectrophotomet, Smartspec. Plus AB3540 4,572.70$ Reader, Bio‐Rad Microplate AB3540 4,299.81$ Protein Array System ‐ Bio‐Plex ‐ AB3540 58,475.01$ Counter, Liquid Scintillation AB3560 26,280.96$ Freezer, Revco Thermo Forma 3801 AB3430 2,989.12$ System: Purification , Water, Diamond AB2061 4,960.94$ System: Purification , Water, Diamond AB2061 4,960.94$ System: Purification , Water, Diamond AB3530 4,960.94$ System: Purification , Water, Diamond AB2053 4,960.94$ System: Purification , Water, Diamond AB3340 4,960.94$ System: Purification , Water, Diamond AB3350 4,960.94$ Freezer, Revco #Ult2 Kendro Products LS3530 7,125.50$ Freezer, Revco #Ult2 Kendro Products LS3580 7,125.50$ Inverted Microscope, Olympus Ix‐51 AB2031 11,713.45$ Shaker, Innova Model 5000 High‐Capacity LS3500 22,427.21$ Shaker, Innova Model 4200 Incubator LS3530 7,509.01$ Shaker, Innova Model 4230 Refrigerator LS3530 8,420.96$ Kit, Carv ConfocalKit, AB2047 66,834.24$ 66,834.24Refrigerator, Chromatography AB3530 3,097.50$ Refrigerator, Chromatography LS3020 3,097.50$ Generator,, Single Polarity AB3580 4,821.06$ Biological Cabinet Envirco AB3460 5,558.01$ Camera System, Sensicam Svga, AB2047 22,601.50$ Analyzer, Phoenix 8000,Uv‐Persulfate AB2064 22,315.30$ Labscale Tff System AB3550 4,302.72$ Centrifuge:Evolution AB3580 41,344.69$ Centrifuge:Evolution AB2038 38,325.28$ Centrifuge, Rc‐5c "Brushless" AB3380 25,328.09$ Centrifuge, Rc‐5c "Brushless" AB2058 25,328.09$ Incubator Shaker, AB3500 13,563.80$ Incubator Shaker, AB3500 13,563.80$ Centrifuge, Brinkman Tabletop AB3520 9,314.19$ Refrigerator/Freezer AB3430 3,126.59$ Chamber, Percival Tissue Incubator AB3500 8,629.64$ Chamber, Percival Tissue Incubator AB3470 8,629.64$ Chamber, Percival Tissue Incubator AB3470 8,629.64$ Chamber, Percival AB3470 9,248.95$ Chamber, Percival Tissue Incubator AB3500 9,248.95$ Chamber, Percival Tissue Incubator AB3470 10,069.65$ Chamber, Percival Scientific Ar‐89 AB1400 58,224.00$ Chamber, Percival Scientific Ar‐89 AB1400 56,336.00$ Shaker, I‐2400 AB3530 8,865.73$ Shaker, I‐2400 AB3530 8,865.73$

Axiovert 40 C AB2044 $

Mini Speedvac, Acid Concentrator AB3530 10,379.70$ Microscope,Axiovert 200m AB2047 65,744.45$ Dialer System, Auto/Predictive IS2300 49,117.40$ Mac 5000 Controller (Olympus Scope) LS4300 7,913.54$ Protean Ief Cell, Basic, Bio‐Rad AB3530 6,009.32$ Analyzer, Em‐Scan, Model Sa‐300 LS3040 4,459.60$ Detection Chamber, Em‐Scan LS3040 3,717.60$ Refrigerator, Powers Scientific AB3550 4,610.71$ Freezer Ultra‐Low Kendro Lab. Prod. AB3540 7,125.50$ Cabinet, Biological Safety AB2046 7,040.70$ Cabinet, Biological Safety AB2046 7,040.70$ Incubator, Nuaire AB2046 8,078.44$ Incubator, Nuaire AB2046 8,078.44$ Incubator, Nuaire Co2 AB2051 8,078.44$ Incubator, Nuaire Nu‐5510 AB113A 4,873.00$ Clean Bench, Edgegard 6' AB3460 6,655.13$ Balance, Mettler‐Toledo LS3430 4,380.00$ Oven: Duo‐Therm Hybridization AB3560 2,644.20$ Electrophoresis System AB3530 5,127.82$ Electrophoresis System AB3550 3,617.50$ Incubator: Percival, Lighted Tissue AB3470 2,790.00$ Microscope, Axiovert 40 CMicroscope, AB2044 3,456.23$ 3,456.23Centrifuge; Beckman Allegra 6kr AB2046 5,459.71$ Computer: Dell Precision 370 AB3110 3,614.13$ Computer: Dell Inspiron 9300 AB101B 3,153.79$ Balance, Scientech 8a310 AB3540 2,672.77$ Balance, Scientech 8a310 AB2058 2,672.77$ Balance, Scientech 8a310 AB2058 2,672.77$ Balance, Scientech 8a310 AB2058 2,672.77$ Freezer, Defrost Model Fms33sd AB3520 3,093.37$ Freezer, Defrost Model Fms33sd AB2058 3,093.37$ Robocycler 96, Gradient AB3330 7,166.28$ Shaker: Gyromax 737r Incubator Shaker, AB3330 8,169.44$ Shaker: Gyromax 737 Incubator Shaker 80 AB3330 5,445.72$ Microcentrifuge, Fisher Benchtop AB3330 3,804.22$ Filtration System, Labscale Tangential AB3300 4,335.03$ Refrigerator: Fisher Chromatography AB3330 3,514.20$ Spectrophotometer: Bio‐Tex Powerwave Xs AB3320 14,408.98$ System: Ceq 8000 Genetic Analysis AB3620 57,262.00$ Incubator Shaker: Innova 44r Series AB3470 15,327.36$ Incubator Shaker: Innova 44r Series AB3470 14,746.37$ Evaporation System, Fisher Scientific AB3440 6,799.87$ Freezer: So‐Low Upright 22 Cu.Ft AB2058 6,305.59$ Freezer: So‐Low Upright 22 Cu.Ft. AB3380 6,305.59$ Freezer: So‐Low Upright 22 Cu.Ft. AB3380 6,305.59$ Vibratory Microtome, Vibratome 1000 Plus AB3520 4,619.66$ Freezer: Lab Rsch. Product Mfp Series AB3330 3,022.77$

Pc: Gel Doc Xr AB3340 $

Freezer: Lab Rsch. Product Mfp Series AB3540 3,022.77$ Freezer: Lab Rsch. Product Mfp Series AB3340 3,022.77$ Osmometer: Wescor Vapor Pressure AB2052 6,013.56$ Refrigerator: Scimetrics Ii Lab AB3440 3,408.08$ Refrigerator: Scimetrics Ii Lab AB3520 3,408.08$ Refrigerator: Scimetrics Ii Lab AB3610 3,408.08$ Refrigerator: Scimetrics Ii Lab AB2064 3,408.08$ Refrigerator: Scimetrics Ii Lab AB2052 3,408.08$ Evaporation System, Labconco Rapidvap AB3330 7,773.02$ Freeze Dry System, Freezone Benchtop AB3330 6,164.59$ Bench: 8' Horizontal Laminar Flow Clean AB3440 9,317.58$ Centrifuge: 5810r Sp Brinkman AB3340 11,015.31$ Centrifuge: 5810r Sp Brinkman AB3440 13,162.25$ Centrifuge: Allegra X‐22r Centrifuge; AB2052 10,665.11$ Shaker: Bench Shaker AB3340 5,267.68$ Balance: Prof Bal. 110/31g X 0.1.01 Mg AB3340 5,267.67$ Spectrophotometer, Nanodrop Techn. AB3530 8,066.78$ Stereomicroscope: Zeiss Stemi 2000c AB3510 4,630.68$ Stereomicroscope: Zeiss Stemi 2000c AB3440 4,050.86$ Camera: Axiocam Mrc, AB3440 7,194.72$ Camera: Dxm 1200f AB2570 8,264.07$ Pc: Gel Doc Xr AB3340 10,310.21$ 10,310.21Centrifuge, Accuspin Micro R AB3340 4,177.78$ Biomate 3 AB3340 4,370.24$ Computer, Dell Xps M170 AB0000 3,321.55$ Kit: Liquid Lab Bioreactor AB3330 3,760.00$ Smartcycler Ii, Desktop System LS4300 33,949.79$ BioCAD 700E Chromatography Workstation AB3620 26,123.70$ CAMERA, 12 BIT COLOR FIREWIRE LS4300 2,653.35$ VIBRATION ISOLATION WORKSTATION LS4300 6,360.00$ Computer, Dell D820 NULL 2,651.42$ FLUROSPECTROMETER AB3340 10,070.00$ PLANT GROWTH CHAMBER AB1400 27,628.90$ GEL DOCUMENTATION CHROMADOC AB3320 3,518.25$ Freezer: Lab Research Product MFP Series AB3610 2,622.44$ Freezer: Lab Research Product MFP Series AB3550 2,622.44$ Freezer: Lab Research Product MFP Series AB3420 2,622.44$ Desktop System, Smartcycler II, SC2000N11. NULL 33,949.79$ Prod LC Oven Dionex AB3350 3,828.62$ C02 Incubator, Hitschfel LS4130 9,964.00$ Adaptis Chamber, Conviron AB1400 44,520.00$ Adaptis Chamber, Conviron AB3470 5,300.00$ Mini Auto Fog, Dramm Corporation AB3050 2,748.66$ Shaker, Innova Model 4200 Incubator AB2037 7,550.91$ Shaker, Innova Model 4230 Refrigerated Incubator AB2037 8,957.53$ Generator: Broad Band Ultrasonic AB3400 3,664.21$ CAMAG LINOMAT 5 AB3350 6,866.68$

Generator: Broadband Ultrasonic AB3400 $

KTO: TiraLab 854/05 AB3610 6,091.47$ Waste Management System Disposal Unit AB1090 7,585.85$ Innova Gyro Platform Shaker AB3400 5,083.98$ Innova Model 2150 Shaker AB3410 3,082.50$ Shaker, New Brunswick Excella E24 AB3610 4,934.48$ Liquid Lab Rocker Kit AB1400 3,392.00$ Liquid Lab Rocker Kit AB1400 3,392.00$ Labconco Freeze Dryer, Freezone AB3590 5,023.51$ Biological Medical Cabinet, Class II, Type A/B3 AB1130 11,410.55$ Generator: Broad Band Ultrasonic Generator AB3370 3,669.15$ PEL 2 MINI HOLDER AB3620 2,767.31$ Zeiss Stemi 2000C Stereoscope AB3440 4,415.48$ Pump System: LPG‐3400A ‐ Ultimate 3000 AB3350 8,545.41$ Sampler: WPS‐3000SL ‐ Ultimate 3000 Analytical AB3350 4,912.72$ Detector: PDA‐3000 ‐ Ultimate 3000 Photo Diode AB3350 14,800.00$ Chromeleon CHM‐1 for HPLC/GC (server, client,) AB3350 3,700.00$ Rotor Ay, TY‐70.1Ti Rotor Ay, AB3380 13,917.20$ Innova Gyro Plat Shaker AB3430 5,132.00$ Medium Animal Chamber AB2034 2,775.00$ Generator: Broadband Ultrasonic AB3400 3,657.00$ Generator: Broadband Ultrasonic AB3400 3,657.00$ Generator: Broadband Ultrasonic AB3400 3,657.00$ 3,657.00Dell Latitude D820 Computer AB0000 2,652.84$ Evolution 300 PC VISIONPRO AB3610 12,664.15$ Microcentrifuge, (IEC) AB2037 5,398.44$ New Brunswick Innova 4000 Incubator Shaker AB3590 2,962.70$ RO‐TAP II Shaker AB3620 2,960.02$ Camera: Leica DFC340 FX Digital AB3310 8,780.23$ Detector, RF2000 Fluorescence AB3350 9,496.25$ Autosampler: Prostar 410 Autosampler AB2064 11,594.44$ Savant SPD121V Speed Vac Concentrator AB3620 4,318.44$ Thermostatted Column Compartment, TCC‐3000‐UltiMate 3000 AB3330 3,593.00$ Rapidvap N2 for 600ML Tubes AB2063 9,984.24$ Spectrometer, IR100 FTIR ‐ Fisher Scientific AB2063 13,546.95$ Zeiss Stemi 2000C Steroscope AB3440 4,399.29$ Freezer, Ultra Low VLU 120 Freezer ‐ Fisher Scientific AB2037 7,882.77$ Laminar Flow Hood, Baker EG5252, 5ft AB1400 7,782.70$ Centrifuge ‐ Allegra 6KR AB1130 5,514.14$ Thermal Cycler: iCycler Thermal Cycler, Demo. 96 LS3020 4,824.50$ FCS2 Starter Set ‐ FCS2 Chamber, ‐ BioVision Technologies AB2050 4,240.00$ Microscope: IlluminatIR II FL Microscope ‐ Smiths Detection AB2050 68,266.80$ Concentrator ‐ Fisher Scientific ‐ AB3620 9,807.24$ 5417R Microcentrifuge ‐ Fisher Scientific AB3610 6,522.67$ Innova Gyro Platform Shaker AB3370 5,184.20$ Dell XPS M1330 Laptop Computer AB1010 2,575.47$ Scanner: Densitometric Evaluation System AB3320 33,999.50$ Chromatron, Model 7924T AB3330 5,294.70$

Microscope ‐ Compound Microscope‐Leica AB3310 32,000.00$ Leica M26 Microscope AB3510 5,400.00$ Leica M26 Miscoscope AB3510 5,400.00$ Freezer: ‐20 C, Manual Defrost Freezer PLUS; AB2032 4,315.36$ Freezer ‐ Upright ‐86 ValPlus 21 cu ft AB2038 9,435.55$ Freezer ‐ Upright ‐86 ValPlus 21 cu ft AB3580 9,435.55$ Mass Spectrometer: MALDI Micro TOF MS System AB3620 141,779.23$

Appendix F

Results of Survey of MBS Faculty

MBS Program 02-27-09

I am the dissertation advisor for one or more students in the MBS program.

Answer OptionsResponse Frequency

Response Count

Yes 47.6% 10No 52.4% 11

answered question 21skipped question 0


I have taught (or directed a team taught) course that is required of ALL MBS students. If so, please type in the name of

Answer OptionsResponse

Count10


Number Response DateResponse Text

1 02/26/2009 20:15:00 Specialized Biochemistry2 02/26/2009 20:19:00 Molecular Genetics and Genomics3 02/26/2009 20:22:00 Advanced Cell Biology MBS62134 02/26/2009 20:23:00 Molecular Genetics and Genomics, Topics, Advance5 02/26/2009 20:28:00 Immunology will be teached for this program6 02/26/2009 21:13:00 MBS 7123 and MBS 62517 02/26/2009 21:15:00 No8 02/26/2009 22:56:00 Advanced Cell Biology, Seminar in MBS9 02/27/2009 19:52:00 advanced cell biology

10 03/01/2009 02:14:00/ / TOPICS IN MOLECULAR BIOSCIENCES


I have taught a course that is an elective that MBS students may, but are not required to take. If so, please enter the course

Answer OptionsResponse

Count8


Number Response DateResponse Text

1 02/26/2009 20:15:00 Techniques in Molecular Biosciences2 02/26/2009 20:22:00 tOPICS IN mbs (FALL, 2007)3 02/26/2009 21:15:00 No4 02/26/2009 22:56:00 Cell Biology, Biochemistry, Pharmacology5 02/27/2009 01:45:00 Yes, MSB Topics6 02/27/2009 19:52:00 plant biotechnology7 02/27/2009 21:22:00 Human Genetics8 03/01/2009 02:14:00 TECHNIQUES IN MOLECULAR BIOSCIENCES


I serve on the MBS Program or Advisory committee.


Response Count

Yes 50.0% 10No 50.0% 10



The multi (or cross) disciplinary focus of the MBS program is:


Response Count

Fundamental to me, my students and our research. It 71.4% 15Nice, but doesn't really matter that much to me. 33.3% 7I don't care one way or the other. 0.0% 0A problem for me and my students. We would be 0.0% 0If you'd like, please add comments here! 5


Number Response Date

If you'd like, please add comments here!

1 02/26/2009 20:22:00 These days all research have become inter-disciplinary, 2 02/26/2009 20:56:00 The current focus of the program offers the necessary f3 02/26/2009 21:13:00 I think the multi disciplinary focus is critical to training/m4 02/27/2009 01:45:00/ / multi-disciplinary component is key to the students educp y p y5 02/27/2009 19:52:00 The flexibility offered by a multi-disciplinary program wo

Comments Question 5 These days all research have become inter-disciplinary, especially where tools and

techniques are concerned. Hence it is only proper our students are trained in such a way that they will not hesitate to pick up, train themselves and use a new tool or technique

The current focus of the program offers the necessary flexibility to accommodate a range of research activities, yet the core curriculum defines a molecular biosciences training that is perfectly suited to this range of research topics and students.

I think the multi disciplinary focus is critical to training/mentoring of students for competitive research jobs. I will stress multidisciplinary aspects, whether or not required by the program. However, I also see there can be situations and students that are benefitted by more narrowly focused (i.e., "traditional") programs.

multi-disciplinary component is key to the students education and their future career opportunities. It is clear the students gain significantly through the cross-disciplinary training and exposure.

The flexibility offered by a multi-disciplinary program would be compromised severely by housing the program in a department. Departments have a very different mission than a broad-based graduate program and the missions could be in conflict. In my opinion the students would suffer.


At present the Director of the MBS Program "reports directly to the Dean of the College of Agriculture and Technology." In terms of


Response Count

Enthusiastic, this arrangement has been very beneficial 47.4% 9I haven't noticed that it has any affect on me, my 42.1% 8It has been difficult. Me and my students would be 10.5% 2If you'd like, please make comments here! 4



If you'd like, please make comments here!

1 02/26/2009 20:58:00 I have no issue with the current structure because it see2 02/27/2009 01:57:00 The structure of cross-disciplinary graduate programs is 3 02/27/2009 19:54:00 This arrangement could change with the person who is 4 02/27/2009 21:23:00 I believe the best structure would be for the PhD directo

Comments Question 6 I have no issue with the current structure because it seems to be working well. The

administrative operations above the MBS Director level seem to be handled smoothly without unnecessarily involving faculty and students, which I take to be a healthy sign.

The structure of cross-disciplinary graduate programs is often a challenge and in my experience, the "higher" you place the program, the easier it is to get buy-in across colleges and departments. If the educational value to students is truely linked to educational experiences that actively cross departmental/college lines, putting the program administration at a level that can effectively encourage and reward paarticipants in multiple units is important. A department has little to incentivize faculty from other colleges or departments to take on teaching (unless the program has lots of dollars and faculty who teach or train students are well compensated which doesn't seem the case at ASU). I think we should even consider putting in real resources and "enpowering" the Graduate School to oversee our multi-disciplinary programs.

This arrangement could change with the person who is dean of the college. Dr. Phillips does a great job with open-minded multi-disciplinarity.

I believe the best structure would be for the PhD directors to report to the Dean of the Graduate School, since these are multidisciplinary programs.


One of the alternatives that has been suggested is that the MBS program would be moved to the Graduate School so that the Dean of the Graduate


Response Count

Enthusiastic. This move would really benefit me, my 40.0% 8I don't think it would really make any difference to me, 15.0% 3I prefer the present structure. I've never had a 45.0% 9My preference is that the program be moved into a 5.0% 1If you'd like, please make comments here! 5



If you'd like, please make comments here!

1 02/26/2009 20:30:00 I actually prefer the present arrangement. However if th2 02/26/2009 21:03:00 The Graduate School is an acceptable alternative to the 3 02/27/2009 02:47:00 Enthusiastic is a bit strong...moving to the Grad School w4 02/27/2009 20:00:00/ / The graduate school is an okay place to house the progrg y p p g5 02/27/2009 21:24:00 Please see previous comments.

Comments Question 7 I actually prefer the present arrangement. However if the program comes under the

graduate school, will it help in terms of admission, application evaluations, fellowship tuition etc.?

The Graduate School is an acceptable alternative to the current structure, but I prefer having an academic college directly involved in oversight. Placing MBS into a single department would have devastating effects on the cross-campus and cross-disciplinary nature of the program, and would very likely result in a much narrower focus for the program, which would likely exclude a number of current participants.

Enthusiastic is a bit strong...moving to the Grad School will only work if it is linked with real resources and staff and the ability of the Grad Dean to link program with TA-ships, support for teaching, recruitment etc.

The graduate school is an okay place to house the program--removes the politics of a particular college for oversight. However, this is a science program and our current situation is facilitated by the dean of agriculture as a scientist--a situation that is likely to always be true. If the dean of the graduate school would be a non-scientist, I believe this might be an issue.

Please see previous comments.


A third option for the administrative governance of the MBS program is that it be moved into a department. My feelings about this change are most


Response Count

That would be great!! It would really benefit me, my 5.0% 1I don't think it would make any real difference to me, 5.0% 1I am concerned that this move would result in a dilution 90.0% 18It would be disastrous for me, my students and my 5.0% 1If you'd like, please add comments here!! 4



If you'd like, please add comments here!!

1 02/26/2009 21:03:00 Departments by definition are narrowly focused disciplin2 02/27/2009 02:47:00 I think this is absolutely the wrong approach. MBS's val3 02/27/2009 20:00:00 Missions are not in alignment.4 02/27/2009 21:24:00 I doubt it would really impact me, but I think the bigger/ / y p , gg

Comments Question 8 Departments by definition are narrowly focused disciplines, so placing MBS into a single

department would be very negative and would likely destroy the cross-disciplinary nature of the current program.

I think this is absolutely the wrong approach. MBS's value is linked with the cross-disciplinary aspects. the teaching of MBS classes involve folks from multiple units and no one department is really even dominant. It would change the "stakeholder dynamics", would be more challenging to administer, and would negatively impact the students.

Missions are not in alignment. I doubt it would really impact me, but I think the bigger picture is served with broader

representation.


In general my preference about the administrative structure of the MBS program is:


Response Count

That it stays at is it (College of Agriculture). 42.1% 8That it be moved to the Graduate School. 63.2% 12That it be moved to the Department of Biological 5.3% 1That it be moved to the Department of Chemistry and 0.0% 0That it be moved to some other Department or College 0.0% 0If you'd like add comments here! 4



If you'd like add comments here!

1 02/26/2009 20:30:00 Will the students get their degree as Ph.D. in MBS from 2 02/26/2009 21:03:00 It seems to me that the majority of faculty involved in M3 02/26/2009 21:22:00/ / If there is no clear evidence or compelling rationale thatp g4 02/27/2009 02:47:00 Either keep it as it is (doesn't seem to be broke) and if n

Comments Question 9 Will the students get their degree as Ph.D. in MBS from ASU or Ph.D. from MBS

from college of Agriculture, ASU? Because our research has nothing much to do with agriculture.

It seems to me that the majority of faculty involved in MBS are members of Agriculture, so this structure makes sense to me. There are faculty from Sciences & Math as well, but not as many, so I could live with placing MBS into Sciences & Math at the dean's level for oversight, but not into one of the departments. The current Dean of Agriculture seems to be supportive and the Dean of Sciences & Math is as yet unknown, so I would prefer to stick with the known support.

If there is no clear evidence or compelling rationale that the administrative change would result in a more effective program, than I do not endorse any change.

Either keep it as it is (doesn't seem to be broke) and if need a change consider expandiing the role and resouces of the Grad School as "enpowered" home for all multi-disciplinary programs.

Appendix G

Miscellaneous Documents: ASU Strategic Plan (12/08/09) ASU Intellectual Property Policy ASU Faculty Performance Evaluation Guidelines MBS Brochure

Arkansas State University Strategic Plan for Academic Affairs and Research Project Matrix

Theme: Academic SuccessPriority 1.1: Increase Student Retention and Graduation Rates

Action Steps Timeline Resources Actions Responsible Party/Parties Status1.1.1 Develop an institutional retention

and graduation planLynita Cooksey , Associate Vice Chancellor for Academic Services; Andy Sustich , Dean of Graduate Schools; Cagri Bagcioglu , Assistant to the Vice Chancellor for Academic Affairs and Research for International Programs and Special Projects

1.1.2 Develop an institutional plan for a seamless transition of transfer students

Cagri Bagcioglu , Assistant to the Vice Chancellor for Academic Affairs and Research for International Programs and Special Projects

1.1.3 Provide increased opportunities for service learning, research, and scholarly activities outside the classroom

Lynita Cooksey , Associate Vice Chancellor for Academic Services, Dean of University College; Other Deans ; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Cagri Bagcioglu , Assistant to the Vice Chancellor for Academic Affairs and Research for International Programs and Special Projects

Priority 1.2: Improve Reputation and Quality of ASU Academic Programs

Action Steps Timeline Resources Actions Responsible Party/Parties Status1.2.1 Continue to develop a campus-

wide culture of assessmentKathryn Jones , Director of Institutional Research and Planning; Lynita Cooksey , Associate Vice Chancellor for Academic Services

1.2.2 Maximize accreditation as appropriate

Lynita Cooksey , Associate Vice Chancellor for Academic Services; All Deans

1.2.3 Develop systematic program review for all programs

Lynita Cooksey , Associate Vice Chancellor for Academic Services; All Deans

1 2/28/2009


Priority 1.3: Recruitment of Higher Quality Students

Action Steps Timeline Resources Actions Responsible Party/Parties Status1.3.1 Assess budgetary impact of

increasing entrance requirements in a staged manner to support retention and graduation planning

Lynita Cooksey , Associate Vice Chancellor for Academic Services; Tracy Finch , Registrar

1.3.2 Enhance relationships with K-12 programs to foster effective pipeline

Ruth Hawkins , Director of Delta Heritage Initiatives; John Beineke , Dean of Education; All Members of AARC

1.3.3 Create an aggressive coordination between AAR and undergraduate admissions

Tammy Fowler , Director of Admissions; Cagri Bagcioglu , Assistant to the Vice Chancellor for Academic Affairs and Research for International Programs and Special Projects; Tracy Finch , Registrar; Lynita Cooksey , Associate Vice Chancellor for Academic Services

1.3.4 Coordinate recruiting technologies between OIP, undergraduate admissions, and graduate admissions

Andy Sustich , Dean of Graduate School; Cagri Bagcioglu , Assistant to the Vice Chancellor for Academic Affairs and Research for International Programs and Special Projects; Tammy Fowler , Director of Admissions

Priority 1.4: Identify, Promote and Foster Faculty Expertise and Excellence

Action Steps Timeline Resources Actions Responsible Party/Parties Status1.4.1 Study and develop budget plan to

move faculty pay to regionally competitive level

Kathryn Jones , Director of Institutional Research and Planning; Dan Howard , Vice Chancellor for Academic Affairs and Research

1.4.2 Budget for ways to enhance faculty professional development and improvement

Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; All Deans

2 2/28/2009


1.4.3 Develop and implement flexible model for assigning and rewarding teaching, service, and research/scholarly activity

Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer

1.4.4 Develop a strategy for establishing and maintaining Centers of Excellence

Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Carole Cramer , Executive Director of Biosciences Institute; Deans Volunteering

1.4.5 Create on-line resources of faculty expertise and productivity

Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer

Priority 1.5: Expand Curricular Accessibility

Action Steps Timeline Resources Actions Responsible Party/Parties Status1.5.1 Increase number and quality of

Distance Learning OpportunitiesMark Hoeting , Associate Vice President of Information and Technology Services; Dan Howard , Vice Chancellor for Academic Affairs and Research; Henry Torres , Director of Center for Learning Technologies; Verlene Ringgenberg , Dean of Center for Regional Programs; Mike Bowman , Director of Distance Learning, All Deans

1.5.2 Coordinate delivery of existing programs to increase accessibility for non-traditional students

Mark Hoeting , Associate Vice President of Information and Technology Services; Dan Howard , Vice Chancellor for Academic Affairs and Research; Henry Torres , Director of Center for Learning Technologies; Verlene Ringgenberg , Dean of Center for Regional Programs; Mike Bowman , Director of Distance Learning, All Deans

3 2/28/2009


Priority 1.6: Enhance Teaching Technologies

Action Steps Timeline Resources Actions Responsible Party/Parties Status1.6.1 Expand Faculty training through

the Center for Learning Technology

Henry Torres , Director of Center for Learning Technologies

1.6.2 Develop teaching technology resource library and training materials

George Grant , Dean of Library; Henry Torres , Director of Center for

Learning Technologies

1.6.3 Implement and support emerging teaching/learning technologies

George Grant , Dean of Library; Henry Torres , Director of Center for

Learning Technologies; Mark Hoeting , Associate Vice President of Information and Technology Services;

Lynita Cooksey , Associate Vice Chancellor for Academic Services

Theme: Campus CulturePriority 2.1: Globalize the University Under the Complementary Themes of "Bring the World to ASU"

and "Take ASU to the World"

Action Steps Timeline Resources Actions Responsible Party/Parties Status2.1.1 Develop a program to provide

cultural awareness training both to incoming international students and existing faculty and students

Carl Lindquist , Academic Advisor for Office of International Programs; Tugrul Polat , Director of International Programs; Gloria Gibson , Dean of Humanities and Social Sciences

2.1.2 Develop social activity programs to involve international students during off-hours

Carl Lindquist , Academic Advisor for Office of International Programs; Tugrul Polat , Director of International Programs; Al Romero , Chair of Biological Sciences; Yvonne Unnold , Chair of Languages; Pradeep Mishra , Instructor of Journalism and Printing

2.1.3 Update curricula to incorporate global cultural, social, and economic issues

All Deans

4 2/28/2009


2.1.4 Promote ASU as the global university in the state of Arkansas

Robert Potts , Chancellor of Arkansas State University; Dan Howard , Vice Chancellor for Academic Affairs and Research; Russ Shain , Dean of Communications; Markham Howe , Director of University Relations

2.1.5 Develop a model to utilize ASU's evolving global network to enhance community and economic development in Arkansas

Len Frey , Dean of Business; Alan McVey , Executive Director of Delta Center for Economic Development; Jerry Smith , Director of Economic Development

Priority 2.2: Transform Arkansas State University Into a More Research Intensive and Globally Prominent University

Action Steps Timeline Resources Actions Responsible Party/Parties Status2.2.1 Create a culture at ASU which

recognizes that scholarship and high quality teaching are inextricably linked and are valued intenure, promotion, and merit decisions

Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Dan Howard , Vice Chancellor for Academic Affairs and Research; Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research

2.2.2 Identify and pursue graduate programs that have the potential to be high demand and cost effective

Andy Sustich , Dean of Graduate School; All Deans

2.2.3 Ensure that library resources and holdings are enhanced to support the expansion of academic offerings

George Grant , Dean of Library; Dan Howard , Vice Chancellor for Academic Affairs and Research

5 2/28/2009


Priority 2.3: Contribute Positively to the Improvement of Shared Governance at the University

Action Steps Timeline Resources Actions Responsible Party/Parties Status2.3.1 Refine and clarify the process of

shared governance to ensure access to valid and reliable data in a timely fashion for all constituencies

Kathryn Jones , Director of Institutional Research and Planning

2.3.2 Recognize meaningful participation by faculty in shared governance as part of institutional service in tenure, promotion, merit, and other decisions

Dan Howard , Vice Chancellor for Academic Affairs and Research; All Deans ; Department Chairs

Priority 2.4: Manage Diversity

Action Steps Timeline Resources Actions Responsible Party/Parties Status2.4.1 Create, promote, and sustain an

environment that fosters the inclusion, support, and success of a diverse student body, faculty, and staff

Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Tugrul Polat , Director of International Programs; Cagri Bagcioglu , Assistant to the Vice Chancellor for Academic Affairs and Research for International Programs and Special Projects; All Deans

2.4.2 Develop curricula that fosters an appreciation of diversity

Lynita Cooksey , Associate Vice Chancellor for Academic Services; All Deans ; All Department Chairs

6 2/28/2009


Priority 2.5: Enhance Continuous Improvement of Support Functions

Action Steps Timeline Resources Actions Responsible Party/Parties Status2.5.1 Analyze and streamline

organizational support processesRobin Hicks , Executive Assistant to the Vice Chancellor for Academic Affairs and Research; Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Lynita Cooksey , Associate Vice Chancellor for Academic Affairs and Research; Dan Howard , Vice Chancellor for Academic Affairs and Research; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer

2.5.2 Create an ongoing process of training and retraining faculty and staff

Andy Sustich , Dean of Graduate School; Tugrul Polat , Director of International Programs; Cagri Bagcioglu , Assistant to the Vice Chancellor for Academic Affairs and Research for International Programs and Special Projects; Tammy Fowler , Director of Admissions; All Deans; Department Chairs

Theme: Increase Revenue GenerationPriority 3.1: Increase State Allocation and Tuition Revenue Based on Funding Formula

Action Steps Timeline Resources Actions Responsible Party/Parties Status3.1.1 Enhance student recruitment All Deans ; All Department Chairs

3.1.2 Expand and increase program offerings

??

7 2/28/2009


Priority 3.2: Increase Non-State Revenues

Action Steps Timeline Resources Actions Responsible Party/Parties Status3.2.1 Develop infrastructure to support

aggressive capital campaign/private donations

Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Christy Valentine , Director of University Development; Cristian Murdock , Vice Chancellor of University Advancement; All Deans ; All Department Chairs

3.2.2 Develop infrastructure to support expanding extramural grants and contracts volume

Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Carole Cramer , Executive Director of Arkansas Biosciences Institute; All Deans

3.2.3 Develop public-private partnershipsto leverage funding

Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Carole Cramer , Executive Director of Arkansas Biosciences Institute; Ruth Hawkins , Director of Delta Heritage Initiatives; Alan McVey , Executive Director of Delta Center for Economic Development; All Deans

3.2.4 Utilize and expand industry and professional training outreach model across disciplines

Verlene Ringgenberg , Dean of Center for Regional Programs; Len Frey , Dean of Business; Alan McVey , Executive Director of Delta Center for Economic Development

8 2/28/2009


3.2.5 Develop and budget infrastructure to support entrepreneurial technology transfer to commercial application

Carole Cramer , Executive Director of Arkansas Biosciences Institute; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Len Frey , Dean of Business; Alan McVey , Executive Director of Delta Center for Economic Development

3.2.6 Develop a model to train and equip science and technology areas with entrepreneurship capability

Carole Cramer , Executive Director of Arkansas Biosciences Institute; Michael Dockter , Associate Vice Chancellor for Research and Technology Transfer; Glen Jones , Senior Associate Vice Chancellor for Academic Affairs and Research; Len Frey , Dean of Business; Alan McVey , Executive Director of Delta Center for Economic Development

Theme: Community EngagementPriority 4.1: Build a Campus Commitment to Community Engagement

Action Steps Timeline Resources Actions Responsible Party/Parties Status4.1.1 Promote and budget for curricular

engagement and service learningLynita Cooksey , Associate Vice Chancellor for Academic Affairs and Research; Ruth Hawkins , Director of Delta Heritage Initiatives; All Deans

4.1.2 Promote and budget private/public partnerships that address community needs

Lynita Cooksey , Associate Vice Chancellor for Academic Affairs and Research; Ruth Hawkins , Director of Delta Heritage Initiatives; All Deans

4.1.3 Plan and budget for academic training in service learning and community engagement


9 2/28/2009


10 2/28/2009

Foundation Research; Ruth Hawkins , Director of Delta Heritage Initiatives; All Deans

4.1.4 Develop and budget for a centralized, coordinated outreach administrative center to facilitate alloutreach functions


4.1.5 Explore and move toward 'Elective Recognition' by the Carnegie

Lynita Cooksey , Associate Vice Chancellor for Academic Affairs and

III.q. Intellectual Property Policy III.q.1.Introduction:

The creativity of human beings is manifested in fields as diverse as science and technology, literature and the humanities, and the fine and applied arts. Creators of intellectual property utilize legal vehicles that make possible the ownership and control of some of the fruits of this creativity, providing an incentive to be creative and to make such fruits public. As a result of the increased cooperation in research and development between universities and businesses, the volume of intellectual property being created in universities has increased significantly. This increase has made apparent the complexity of the issues related to the ownership, control, and use of such property. This policy is designed to achieve the following objectives:

a. Encourage and protect the creative endeavors of all members (faculty, staff, and students) of the University community; b. Determine and safeguard the rights and interests of all relevant parties (Originator, the University, and outside sponsors of research) in the creative products of those associated with the University; c. Facilitate the dissemination and use of the findings of academic research so as to benefit the public at the earliest possible time; d. Provide guidelines by which the significance of the findings of the academic research may be determined and, when appropriate, their public use facilitated; e. Recognize the equity of any outside sponsor of research within the University, assist in the negotiation and preparation of contracts with outside sponsors, collaborators, and licensees, and support the fulfillment of the terms of those contracts; and f. Provide for the equitable distribution of benefits resulting from the intellectual property among the various parties (Originator, the University, and outside sponsors of research) with interests in it.

III.q.2.Persons Affected: The Intellectual Property Policy applies to all persons employed by the University System and the component institutions of the System, to anyone using System facilities unless otherwise negotiated, to all students including, but not limited to, undergraduate students and candidates for masters and doctoral degrees, and to postdoctoral fellows. It shall also apply to all persons not employed by the University but whose scholarly production is financed, in whole or in part, from funds under the control of the University.

III.q.3.Definitions: The following definitions are employed in interpreting and implementing this policy:

a. "Intellectual Property" refers to any material capable of legal protection (copyright, license, and patent) arising out of Scholarly Production and includes, but is not limited to, any discovery, invention, process, know-how, design, model, work of authorship, works of art, computer software, mask work, molecular, cellular or organismal biological discoveries or applications, strain, variety or culture of an organism, or portion, modification, translation, or extension of these

items. It includes marks used in connection with these. The term "mark" refers to trademarks, service marks, collective marks, and certification marks. b. “University” means the Arkansas State University System and any entity or activity under the authority of the Board of Trustees of the Arkansas State University System. c. “Scholarly Production” means any research, creative activity, or development activity, which is directly related to the duties and responsibilities for which a person has been compensated by or through the University, or for which facilities owned, operated, or controlled by the University are used. d. “Sponsored Research” means Scholarly Production for which the University has received external support from some third party. e. “Originator” means a person who in the course of Scholarly or Creative Production creates or discovers material that is or becomes Intellectual Property. f. “Copyright” shall be understood to mean that bundle of rights that protect original works of authorship fixed in any tangible medium of expression, now known, or later developed; from which they can be perceived, reproduced, or otherwise communicated, either directly or with the aid of a machine or device. g. “Works of authorship” (including computer programs) include, but are not limited to, the following: literary works; musical works including any accompanying words; dramatic works including any accompanying music; pantomimes and choreographic works; pictorial, graphic, and sculptural works (photographs, prints, diagrams, models, and technical drawings); motion pictures and other audiovisual works; sound recordings; and architectural works. h. “Tangible media” include, but are not limited to, books, periodicals, manuscripts, phonographic records, films, slides, tapes, and disks. i. “Patent” shall be understood to mean that bundle of rights that protect inventions or discoveries which constitute any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof; computer software; new and ornamental designs for any useful article; new human-made products; and new animal, plant, or other life forms. This includes new plant varieties created by sexual reproduction and covered by Plant Variety Protection Certificates for New Cultivars. j. “Royalty-free license” shall be understood to mean an exclusive or nonexclusive, nontransferable license for unrestricted use of the invention, the license being without royalty payments on any subsequent proceeds.

III.q.4. Statement of Policy: It shall be the policy of the University to acquire and retain legal title to all Intellectual Property created by any person or persons to whom this policy is applicable. This policy is established in furtherance of the commitment of the University to the widest possible distribution of the benefits of Scholarly or Creative Production, the protection of Intellectual Property resulting from such creation or discovery, and the development of Intellectual Property for the public good.

III.q.5. Determination of Ownership:

These are the guidelines and circumstances to be considered by the University in determining ownership:

a. The University owns the Intellectual Property: 1. If intellectual property is created by an employee within the scope of employment; or 2. If intellectual property is created during performance of professional duties, with System facilities or University or state financial support; or 3. If intellectual property is commissioned by the System or a component thereof, or if it fits within one of the categories of works considered works for hire under copyright law; or 4. If intellectual property results from research supported by Federal funds or third party sponsorship, such funds awarded to the University or System, subject to the conditions of the contract or agreement. 5. If intellectual property is computer software, including computer programs, computer databases and associated documentation (herein “computer software”), whether copyrightable or patentable, produced by any person to whom this policy is applicable, that intellectual property shall belong to the University. Revenues generated by the commercialization of computer software shall be shared with the originators or inventors according to the Distribution of Earnings from Intellectual Property of this policy document. Computer software produced on an Originator’s own time or through permissible consulting activities and without the use of facilities owned, operated, or controlled by the University shall belong to the Originator and all rights thereto may be retained or assigned by the Originator.

b. The Originator owns the Intellectual Property: 1. If it is unrelated to the Originator's job responsibilities and the Originator made no more than incidental use of System resources; or 2. If it has been released by the University to the Originator under this Intellectual Property Policy; or 3. If the intellectual property is a Work of Authorship (e.g., a textbook, manuscript, work of art, musical composition) in the author’s field of expertise, even though such a work may have been created within the scope of employment, so long as (a) no extraordinary system resources were used or (b) it was not created by someone who was specifically hired or required to create it as stated in a contract with clear ownership definitions; or 4. If the Intellectual Property is copyrighted and was created, made, or originated by a University employee or student and is related to that employee’s or student’s professional field so long as (a) no extraordinary system resources were used and (b) it was not created by someone who was specifically hired or required to create it as stated in a contract with clear ownership definitions.

III.q.6. Disclosure Obligations of Originator: All persons to whom this policy is applicable shall furnish to the Office of Research and Technology Transfer a full and complete disclosure of any Intellectual Property

promptly after it is created or conceived or first reduced to practice. The disclosure will identify all Originators of the specific Intellectual Property, their relative contributions to the work (expressed in a percentage), and their use of University resources in developing the work including departments, interdisciplinary programs, research institutes, and sponsors (expressed in a percentage). Such persons shall cooperate in a timely and professional manner with the University or with patent or other counsel in protecting Intellectual Property and perform all acts necessary for the University to fulfill its obligations and protect the University's rights in and to the Intellectual Property. The University may require technical advice and assistance from Originators in the development and licensing of their Intellectual Property. The University’s disclosure form is provided at http://asuresearch.edu.

III.q.7.Assignment of Copyrighted Intellectual Property Rights and Predetermined Disposition of Certain Copyrights:

The University shall own and have continuing interest in Copyrighted Intellectual Property in the following two circumstances:

a. The author has voluntarily transferred the copyright, in whole or in part to the institution. Such transfer shall be in the form of a written document, signed by the author. Certain "works for hire" may require an agreement in writing be negotiated between the faculty, staff, or student, the University, and any third party prior to commencement of the work. b. The University has contributed to a "joint work" or commissioned a work under the Copyright Act. The institution can exercise joint ownership under this clause when it has contributed specialized services and facilities to the production of the work that goes beyond what is traditionally provided to faculty members. Such arrangement is to be agreed to in writing, in advance, and in full conformance with other provisions of this agreement. The University will not assert an interest in: a. Faculty produced, copyrightable online courses other than to reserve a nontransferable, royalty-free use license so long as the copyrightable Intellectual Property meets the definition of Originator owned Intellectual Property section III.p.5; or b. Copyrightable material created for ordinary teaching use in the classroom or for electronic assignments and tests so long as the copyrightable Intellectual Property meets the definition of Originator owned Intellectual Property section III.p.5; or c. Copyrightable faculty, staff, or student produced textbooks, scholarly writing, art works, musical compositions, and literary works that are related to the faculty, staff, or students’ professional field so long as the copyrightable Intellectual Property meets the definition of Originator owned Intellectual Property in section III.p.5.

The University shall be permitted to use any of the above-enumerated materials for internal instructional, educational, and administrative purposes, including satisfying requests of accreditation agencies for faculty-authored syllabi and course descriptions. In an agreement transferring copyright for such works to a publisher, faculty authors are urged to provide rights for the University to use such works for

http://asuresearch.edu/

internal instructional, educational, and administrative purposes. For any disputes concerning copyright ownership (such as equitable division among joint Originators) not specifically addressed in this policy, the University System Intellectual Property Committee (USIPC) will review all copyright disclosures and make a recommendation to the administration as to who owns the copyright. The Originator(s) will be notified of the outcome within 90 days of receiving the disclosure. Funds received by the faculty member from the sale of copyrighted intellectual property assigned to the faculty author or inventor shall be allocated and expended as determined solely by the faculty author or inventor.

III.q.8. Assignment of Patented Intellectual Property Rights: The associate vice chancellor for research and technology transfer will review all invention disclosures and recommend to the administration one of three possible actions:

a. Assign all rights to the Originator; or b. Assign all rights to the Originator but retain a nontransferable royalty-free license; or c. Retain all ownership rights and develop the Intellectual Property for commercialization at the University's discretion.

If the University does not furnish notice of intent to retain ownership rights of the Intellectual Property within 90 days after disclosure to the University, the rights to the Intellectual Property vest in the Originator unless the Originator allows for as much as two 30-day extensions. Furthermore, if the University chooses to patent an Intellectual Property but takes no steps (within two years of notice of intent to retain ownership rights of the Intellectual Property) to develop the Intellectual Property commercially, the Originator may request that the University transfer or waive its rights subject to the retention by the University of a non-transferable, royalty-free license.

III.q.9. Costs of Legal Protection of Intellectual Property: The holder of the Intellectual Property rights bears the responsibility and financial burden of developing and processing the Intellectual Property, and all legal fees and other costs related to obtaining and maintaining patents, copyrights, or other legal protection, unless otherwise negotiated.

III.q.10. Distribution of Earnings from Intellectual Property: In consideration of the disclosure and assignment of Intellectual Property to the University, the net royalties or other net income from the commercialization of an Intellectual Property will be distributed as follows (Note: Net royalties are for this purpose defined as gross royalties received by the University minus the costs for patenting, copyrighting, licensing or obtaining legal protection of Intellectual Property. This does not include salaries of the Originator or the Office of Research and Technology Transfer staff.):

a. For the first $10,000 of net royalties or other net income the Originator, Originator's heirs, successors, or assigns shall receive eighty-five percent (85%) of those net royalties or other net income with the remaining fifteen percent (15%)

being dedicated to the University research initiatives as established in the agreement regarding the intellectual property. b. Once the $10,000 plateau has been reached, net royalties or other net income up to two million dollars will be divided fifty percent (50%) to the Originator, Originator’s heirs, successors, or assigns with fifty percent (50%) being dedicated to the University research initiatives as established in the agreement regarding the intellectual property. c. Once Intellectual Property generates net royalties or other net income that exceeds two million dollars, net royalties or other net income will be divided forty percent (40%) to the Originator, Originator’s heirs, successors, or assigns and sixty percent (60%) to the University research initiatives as established in the agreement regarding the intellectual property.

Net royalties will be distributed normally on an annual basis, payments being made within sixty (60) days after the end of a calendar year in which royalties from the Intellectual Property have accrued.

III.q.11. Sponsored Research: Rights to Intellectual Property produced as a result of Sponsored Research, including research sponsored by the University Research Foundation, are determined by the contractual or grant agreements negotiated between the University and the sponsor. Allocation of such rights may take one of several forms; the following are the most common:

a. The University may retain all rights or assign them to the Originator or sponsors; or b. The University may grant a nonexclusive license to the sponsor; or c. The University may grant an exclusive royalty-bearing license to an entity in exchange for an equity stake in the stocks or proceeds of the entity; or d. The University may grant the sponsor a right of first refusal to an exclusive royalty-bearing license for a limited term or for the life of the Intellectual Property; or e. The University may grant the sponsor all rights to any Intellectual Property which result from the particular Sponsored Research where it is determined that the holding of title to the Intellectual Property will confer no substantial benefit to the University; f. The University may grant the sponsor all rights to any Intellectual Property when the research project is considered by the University to be of a public benefit compatible with the aims and purposes of the University or the Sponsor.

III.q.12. U.S. Government Funded Inventions: The University, as are other research universities, is governed by the 1980 Bayh- Dole law (P.L. 96-517 and 98-620 as amended), which sets out the disposition of inventions made with Federal assistance. The law provides that non-profit organizations and small businesses may elect to retain title to the inventions conceived or first actually reduced to practice in the performance of work under a funding agreement. The University must disclose each subject invention in a timely

manner and comply with other regulatory actions. In addition it must grant the U.S. government a royalty free license for governmental purposes, give preference to U.S. manufacturers, give preference to small businesses, and share royalties with inventors. The University must periodically report any licensing activity to the Government.

III.q.13. Publication Rights: In all Sponsored Research, the right shall be reserved for Originators and the University to publish and disseminate the knowledge gained and the results obtained. The University may grant a sponsor a limited review period of 60 (sixty) days, renewable with permission of the Originator, prior to publication in order to protect proprietary information and any technology, which may be the subject of a patent application.

III.q.14. Policy Administration: The president shall appoint a University System Intellectual Property Committee (USIPC) consisting of five faculty members from the Jonesboro campus and one representative from each other campus conducting significant scholarly work. The vice chancellor for research and academic affairs, vice president for finance and administration, and the associate vice chancellor for research and technology transfer shall be ex officio members of the Committee. The University attorney shall serve as legal advisor to the Committee. A chair shall be elected from among the membership of the Committee. The Committee shall meet at least annually and also when needed at the request of the chair or the president. The Committee shall be responsible for:

a. Reviewing the operation of the University Intellectual Property Policy and proposing policy changes; b. Assisting in the review of Intellectual Property disclosures as requested by the Office of Research and Technology Transfer; c. Reviewing disputes concerning copyright ownership (such as equitable division among joint Originators) not specifically addressed in this policy and make a recommendation as to who owns the copyright to the administration; d. Reviewing proposed exceptions to the established policy; e. Seeking initial resolution of campus disputes relating to rights in Intellectual Property and resolving issues referred by the associate vice chancellor of research and technology transfer; f. Advising the president on Intellectual Property policy matters as requested. The associate vice chancellor for research and technology transfer shall have the general responsibility of:

a. Reviewing Intellectual Property disclosures submitted to the University for patent or trademark application or other protection and making recommendations to the University System Intellectual Property Committee; b. Evaluating Intellectual Property for patentability, as well as potential commercial value;

c. Appointing ad hoc technical subcommittees to assist in evaluating Intellectual Property; d. Seeking University approval of outside technical assistance in evaluating Intellectual Property; e. Recommending Intellectual Property rights or equities to be held by the University Research Foundation; f. Providing scientific and technical assistance to approved patent management organizations to achieve the full benefits of University Intellectual Properties that have commercial potential; g. Seeking initial resolution of campus disputes relating to rights in Intellectual Property; h. Reviewing works of authorship submitted for copyright consideration; and i. Transferring technology including, but not limited to, licensing patents and developing plans for commercialization of University owned Intellectual Property.

Within ninety (90) days of the receipt of an Intellectual Property disclosure, the Office of Research and Technology Transfer will review and evaluate the Intellectual Property disclosure and submit to the vice chancellor for research and academic affairs its recommendation regarding the disposition of the disclosure. The Office of Research and Technology Transfer recommendation along with the vice chancellor for research and academic affairs recommendation shall be forwarded within approximately ten (10) days of receipt to the president of the University. In most instances the recommendation will consist of one of the following:

a. The University retains property rights and will proceed toward commercial development; or b. The University assigns all rights to the Originator or sponsor while reserving a royalty-free use license; or c. The University assigns all rights to the Originator or sponsor.

Arkansas State University MolecularBiosciencesAn Interdisciplinary

Doctoral Program

www.astate.edu

Founded in 1909, ArkansasState University (ASU) is one ofthe premier institutions of high-er education in the state. Withtechnologically advanced facili-ties and a population of more

than 15,000 students (including those at the sister cam-puses), the university is a major education force in thestate. The Jonesboro campus, which is located on 900acres, has a student population of more than 10,000.Students come from nearly all 50 states and territoriesand 54 countries.

ASU is a state-assisted university located in northeastArkansas, 70 miles (1 hr.) from Memphis, Tennessee. Theuniversity offers a wide variety of majors to studentsfrom diverse backgrounds and ethnicities. Jonesboro is aquiet, safe community of about 55,000 inhabitants.People are friendly and very helpful. Recreational oppor-tunities abound in the Ozark foothills to the west.

Thomas Wheeler, DirectorArkansas State University

Molecular Biosciences ProgramCollege of Engineering

P.O. Box 1740State University, AR 72467

Phone: 870-972-3300Fax: 870-972-3948


experiences challengesOp

portunity

Ex c e ll e nce

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Jonesboro, Arkansas

For more information, please contact

• Applied genomics and metabolomics

• Molecular tracking in cells, organisms and environments

• Plants engineered for drug and vaccine production

• Molecular diagnostics

• Drugs - from molecular interactions to behavior

• Nano-detection systems

Discovery at the

Interface

The Program provides unique opportunities to link with industryfrom research projects that solve real life problems, to exposureto issues of scientific ethics and intellectual property to intern-ships with knowledge-based technology spin-off companies.

Program is designed to ensure that students are on the cuttingedge of their fields with experiences in problem-solving and cross-disciplinary team approaches for professional competitiveness.


Molecular Biosciences Program

Graduate Student Support


Molecular Biosciences Program

The cross-disciplinary Molecular Biosciences field is rev-olutionizing discovery and technological advances in dis-ciplines ranging … from agriculture to medicine,

… from forensics to environmental sciences …from food sciences to renewable energy.

The Molecular Biosciences Graduate Program providestraining and research opportunities that integrate cellu-lar, molecular, developmental and genomic informationand knowledge. The program has a strong emphasis oninterdisciplinary approaches, state-of-the-art technolo-gies and innovation to address real world problems.

Research Environment. Students will have the opportuni-ty to study and perform research in the new ArkansasBiosciences Institute building on the ASU campus. Thisbuilding supports state of the art facilities for planttransgenics, mammalian cell biology, detection and ana-lytics, metabolic engineering, and genomics. The build-ing has an “open lab” design and houses dynamic facultyfrom different departments and disciplines supporting atruly cross-disciplinary and highly interactive researchenvironment. Student productivity is also supported by astudent-centered learning environment including office,reading, and meeting areas integrated within theresearch clusters.

Any university support,whether as a GraduateTeaching Assistant or as aGraduate Research Assistant,may be arranged within thedepartment of the sponsoringfaculty member, or awardedcompetitively through theMolecular BiosciencesProgram Committee.

Program Mission Entrepreneurial Environment

Unique Features

Faculty Contacts

Professional Opportunities

Tom Wheeler, Admissions and Academic [email protected] (870) 972-3300

Carole Cramer, Plant-based Protein [email protected] (870) 972-2025

Greg Phillips or Fabricio Medina-Bolivar, Plant Metabolic [email protected] (870) 972-2085 or (870) 680-4319

Maureen Dolan or Joseph Awika, Molecular Innovations in Food [email protected] (870) 680-4359

Roger Buchanan, Human [email protected] (870) 680-4297

Robyn Hannigan, Analytical [email protected] (870) 680-4360

I Description Each academic department within Arkansas State University conducts an annual performance review of each teaching member of the faculty (full-time, part-time, and graduate teaching assistants), both tenured and non-tenured, within the department to ensure a consistently high level of performance. Although each department may devise a review process that best addresses its particular needs and traditions, the review must consist of at least the following elements:

Review of Student Evaluations. At least once a year, department chairs conduct student evaluations of each teaching member of the faculty. Student evaluations serve as one of the three major elements in the annual review of faculty. Faculty members absent themselves from classes, evaluation instruments are administered to students by chairs or their representatives, and chairs compile results. Chairs discuss student evaluations with faculty members after courses have concluded for the semester. Review of English Proficiency. Student evaluations of faculty include a section of evaluation of English proficiency of the faculty member. Should English deficiencies be identified, department chairs will take reasonable measures to provide opportunities to assist deficient faculty members in becoming proficient in English and will report the steps being taken to the dean. Ultimate responsibility for acquiring English proficiency rests with the faculty member. Concerns raised by students regarding language proficiency of faculty prior to student evaluations will be addressed by the department chair. Review of Course Syllabi. For each course taught, faculty members file syllabi with the department chair, who reviews them for objectives, material covered, reading required, grading policy, and special requirements. Review of Annual Productivity Report. Each faculty member compiles annually a report of productivity, outlining involvement in teaching, research and service. Typically, the productivity report documents development of new courses; teaching assignments; supervision of undergraduate and graduate research, independent study, and readings; service on thesis and comprehensive exam committees; use of nontraditional teaching techniques; publication and creative activities; paper presentations; editorials activities; manuscript preparations; grant applications, involvement in student advisement; participation in committee work; special university assignments; student recruiting activities; and other service activities.

Additionally, depending on the particular needs and traditions of the department, the review process may include class visitation, examination of graduation check sheets supervised by individual advisers, review of exhibitions and performances, review of theses chaired, and review of previously agreed upon goals and objectives. Annual assessment of faculty performance does include review of tenured faculty as outlined in the university=s Post-Tenure Review policy. The purpose of post-tenure review is to ensure that tenured faculty are meeting their responsibilities through full productivity and satisfactory performance. Unsatisfactory performance will result in a near-term plan of improvement and professional development.

II. Assessment by peers, students, and administrators Department chairs combine results of student evaluations, review of course syllabi, review of annual productivity reports, and other assessment techniques used by the department to rank faculty in terms of annual performance. Ranking techniques may vary throughout departments, but are developed by chairs in concert with faculty peers. Faculty peers serve a major role at the department, college, and university levels in promotion and tenure recommendations. Faculty peers also work with chairs to develop ranking techniques on which merit salary recommendations are made. Chairs then develop a merit salary recommendation correlating with annual performance rank. Administrators_ chairs and deans_ review all assessment materials and make merit salary, retention, promotion, and tenure recommendations based on the annual performance review and the more intensive promotion and tenure evaluation process. Faculty ranking and merit salary recommendations are passed from the chair to the college dean, who reviews all recommendations and forwards them to the vice chancellor for Academic Affairs and Research. All recommendations are reviewed, and final recommendations provided to the president of the University. III. Uses of the Faculty Performance Review The annual faculty performance review is used in relation to promotion, salary increases, job retention, to redirect faculty efforts to improve or to increase productivity, and to identify and correct instances of substandard performance. The annual performance review is also related directly to job retention for pre-tenured faculty. Department chairs use all elements of the annual review to recommend retention or termination of pre-tenured faculty members. For promotion and tenure, the required review is even more intensive than the annual performance review. All evaluative materialsBcovering the total pre-tenure period since the last promotional go to the a department committee of peers. Thereafter, the faculty member=s file moves through a process involving the department chair, a college committee of peers, the college dean, a university committee of peers, the vice chancellor for Academic Affairs and Research, and the president of the university. At all levels, evaluators consider evidence of teaching ability, research, publication, presentations, creative activities, and service to the public and to the university. (Full-time faculty in the College of Education are required to work collaboratively with accredited public schools in the area, and such involvement will be included as part of the annual review of the faculty member.) The annual review is not ever used to demote a tenured faculty member to a non-tenured status. IV. Institutional Monitoring of the Annual Faculty Performance Review The annual performance review process for purposes of merit salary recommendations and retention recommendations is monitored by college deans and the vice chancellor for Academic Affairs and Research, who annually collect and review student evaluation instruments and productivity reports, and who examine faculty ranking by departments to assure that a direct positive relationship exists between rankings and merit salary recommendations.

The performance review process for purposes of promotion and tenure recommendations is monitored annually by a university committee of faculty peers. (The vice chancellor for Academic Affairs and Research is a non-voting member of the committee.) The committee reviews all department promotion and tenure criteria for clarity and conformity to university standards. V. Institutional Evaluation of its Annual Faculty Performance Review Each faculty member will be informed annually by the department chair where that member ranked relative to all other department members. Chairs will be expected to be prepared to explain to faculty members how rankings were determined. When rankings cannot be explained satisfactorily, deans will work with chairs to reform the process. Each college dean will review annually the faculty performance review system at the department and college level. Deans will seek to determine that review elements satisfactorily explain faculty rankings, and that rankings do relate directly to merit salary recommendations. The vice chancellor for Academic Affairs and Research will work with college deans to review annually the results of the performance review system and will recommend revisions when appropriate.