Title: GRAd-COV2, a gorilla adenovirus based candidate vaccine against 1 COVID-19, is safe and immunogenic in young and older adults 2 Authors: Simone Lanini 1† , Stefania Capone 2† , Andrea Antinori 1 , Stefano Milleri 3‡ , Emanuele 3 Nicastri 1 , Roberto Camerini 2 , Chiara Agrati 1 , Concetta Castilletti 1 , Federica Mori 2 , Alessandra 4 Sacchi 1 , Giulia Matusali 1 , Roberta Gagliardini 1 , Virginia Ammendola 2 , Eleonora Cimini 1 , 5 Fabiana Grazioli 2 , Laura Scorzolini 1 , Federico Napolitano 2 , Maria Maddalena Piazzi 1 , Marco 6 Soriani 2 , Aldo De Luca 1 , Simone Battella 2 , Andrea Sommella 2 , Alessandra M. Contino 2 , 7 Federica Barra 2 , Michela Gentile 2 , Angelo Raggioli 2 , Yufang Shi 4,5 , Enrico Girardi 1 , Markus 8 Maeurer 6,7 , Maria R. Capobianchi 1 , Francesco Vaia 1 , Mauro Piacentini 8 , Guido Kroemer 9,10,11,12 , 9 Alessandra Vitelli 2 , Stefano Colloca 2 , Antonella Folgori 2† , Giuseppe Ippolito 1†‡* 10 11 Affiliations: 12 1 Istituto Nazionale per Le Malattie Infettive Lazzaro Spallanzani IRCCS; Rome, Italy. 13 2 ReiThera Srl; Rome, Italy. 14 3 Centro Ricerche Cliniche di Verona srl; Verona, Italy. 15 4 First Affiliated Hospital of Soochow University; Suzhou, Jiangsu, China. 16 5 Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese 17 Academy of Sciences; Shanghai, China. 18 6 Division of Immunotherapy, ImmunoSurgery, Champalimaud Foundation; Lisboa, Portugal. 19 7 I Medical Clinic, University of Mainz; Mainz, Germany. 20 8 Department of Biology, University of Rome "Tor Vergata; Rome, Italy. 21 9 Sorbonne Université, Institut Universitaire de France; Paris, France. 22 10 Metabolomics and Cell Biology Platforms, Institut Gustave Roussy; Villejuif, France. 23 11 Pôle de Biologie, Hôpital Européen Georges Pompidou; Paris, France. 24 12 Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, 25 Sweden 26 * Corresponding author. Email: [email protected] 27 † These authors contributed equally to this work 28 ‡ on behalf of the GRAd study group 29 30 One Sentence Summary: GRAd-COV2, a candidate vaccine for COVID-19 based on a novel 31 gorilla adenovirus, is safe and immunogenic in younger and older adults 32 33 34 35 . CC-BY-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted April 13, 2021. ; https://doi.org/10.1101/2021.04.10.21255202 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
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