Gold Neoplastics

Gold Collection

Anti-neoplastic

•Cyclosporine

– Protects against rejections from organ

transplants– Does not induce bone

marrow depression

•Cyclophosphamide

–Alkylating agent of both purine & pyrimidine

bases of DNA– Txt CLL

•Cisplatin’s toxicities

•Nephro- & Ototoxicity

•Methotrexate

–Antimetabolite of folic acid:

(-)dihydrofolate reductase

•Leucovorin Rescue

•Can block/reduce Methotrexate =

increase folic acid via a reduced folate

•Bleomycin toxicities

•Pneumonitis & pulmonary fibrosis

•Azathiorine

– Used in organ transplantation = kidney

allografts– Allopurinol can increase

its activity by (-) its biotransformation to

xanthine oxidase

•Chemotherapy used in the txt of Hodgkin’s

disease

• MOPP – M = Mechlorethamine - nitrogen

mustard– O = Oncovin (Vincristine) -

prevents microtubule assembly– P = Procarbazine

– P = Prednisone - glucocorticoid, inducing apoptosis

•Tamoxifen

–(-) estrogen receptor– Txt of breast tumors, can see

associated endometrial CA

•Flutamide

–Antiandrogenic– Used w/ Leuprolide

(LH-RH analog)– Txt prostatic CA

•Megestrol

–(-) progesterone receptor

– Txt endometrial CA

•Fluoxymesterone

–Androgenic steroid– Txt mammary CA in

postmenopausal women

•Methotrexate

–Folic acid analog that (-) tetrahydrofolate synthesis

by (-) dihydrofolate reductase

– Txt of ALL– Txt of Psoriasis

•Brain tumor Txt

–Lomustine– Carmustine - Causes

pulmonary fibrosis

•Streptozocin

–Attaches to β cells– Txt of pancreatic

insulinomas

•Cytarabine (AraC)

–Pyrimidine analog– DOC for AML

•Dactinomycin

•Used for Wilms tumor & rhabdomyosarcoma

•Etoposide

•Used for oat cell CA

•Paclitaxel

–Used for ovarian CA

•Amifostine

•Can decrease nephrotoxicity due to

chronic use of Cisplatin