Gokaraju Rangaraju College of Pharmacy Imparts ... 1.pdf1 1 Half yearly news letter Volume-1, Aug 2011 Gokaraju Rangaraju College of Pharmacy Imparts Pharmaceutical Education of International

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Half yearly news letter

Volume-1, Aug 2011

Gokaraju Rangaraju College of Pharmacy

Imparts Pharmaceutical Education of International Standards

Bachupally, Hyderabad-90. Andhrapradesh, India

Reach us @ http://grcpapex.blogspot.com

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1. Moto of GRCP Infoapex

2. Natural focus – Known and unknown

3. Technology focus – Updates

4. New magic bullets

5. GRCP events

6. WOW activities

7. Institution upgrade

8. Future focus

Contents

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Our principal Prof CVS Subrahmanyam inaugurating the GRCP Infoapex, (poster bulletin) on 26th Jan 2011,

Final year students B Pharmacy students picture also inserted.

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Brown Rice

Why brown rice?

Brown rice is a complex carbohydrate that provides 15 essential nutrients, including B-vitamins and

potassium. In the olden days, paddy used to be hand pounded and winnowed to remove the husk and

consumed as such. Nowadays whole rice is milled minimally to remove the husk to get the brown

rice. Polishing removes the layer that is filled with health-supportive, essential fats that make rice

highly susceptible to oxidation. Though this extends the shelf life of the product, the resulting white

rice is simply a refined starch that is largely deprived of its original nutrients.

Role in Diabetes

Brown rice retains all the nutrients that Nature bestowed it with. Brown rice is every weight watcher’s

dream food. A common sense approach to obesity control is to eat foods that have low glycemic index

(GI), like raw vegetables and fruits and whole grains.

Being insulin resistant means your body stops responding to insulin, and instead deposits every calorie

as fat. By metabolizing slowly and maintaining stable levels of blood sugar and/or serotonin, brown

rice snips away food cravings. By contrast, processed food releases a short burst of serotonin, but soon

returns to low-serotonin state and causes cravings for more sugar and simple carbohydrates.

Antioxidant Potential

Brown rice has antioxidants and phytonutrients that boosts the immune system, lowers cholesterol,

reduces risk of heart disease, stroke and colon cancer, and reduces severity of asthma. Brown rice can

substantially reduce the risk of colon cancer, as it is a a very good source of selenium, a trace mineral

that induces DNA repair and synthesis in damaged cells and inhibits the proliferation of cancer cells.

Selenium is an antioxidant and is essential for thyroid hormone metabolism and immune function.

Conclusion

Regular use of brown rice plays a vital role in keeping Health, MORE WEALTH

“Emphasized that god realization is a supreme goal of all living beings”

…. Ramakrishna Paramahamsa

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Easy Way to Improve Health

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Ayurveda states that even the correct drug may not produce lasting effect, unless the life style and diet

are attended to. Most degenerative diseases like arthritis results from persistent stress. Knowledge of

good dietary practices was deeply embedded in India’s traditional culture

Evidence

A typical method of cooking rice, appears to be very effective in helping musculoskeletal conditions.

The method removes extra starch and generally improves nutritional value, and makes beneficial

conditions for several degenerative disease conditions.

Cooking methodology

Cook rice with enough excess of water and drain off any excess water remaining which most soluble

carbohydrate are removed so sugar loading is decreased

Making use of drain water

Drain water can be offered to animals and plants which provides nutrient effect

It can be mixed with buttermilk and pinch of fenugreek seed and ferment overnight

The strain of yeast grows on fenugreek seed will give additional effect

Therapeutic value

Reduction in the kappa content decreases tendencies of constipation

Added microbial content from the yeast and lactobacillus considerably increase nutritional

value

Associated benefits

Decrease in sugar loading reduces obesity, insulin resistance, metabolic syndrome and type 2

diabetes and improves colon health

Exploring the important clinical therapy components from AYURVEDA and Dietary recipes

for better treatment is of crucial….

…. as they give WEALTH to the HEALTH in a very easy way.

If you want a love message to be heard, it has got to be sent out. To keep a

lamp burning, we have to keep putting oil in it

Mother Teresa

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Mother‘s Milk

Breast milk supports the foundation of infant growth and development in the first few months of life

and it sets better foundation for the health in later stage too. The breast milk can never ‘emptied’, since

milk production is a continuous biological process

The initial milk produced is referred to as colotrum, which is high in the immunoglobulin (IgA),

• IgA coats the gastrointestinal tract and protects the newborn until its own immune system is

functioning properly

• It creates mild laxative effect, expelling meconium and helping to prevent the build up of

bilurubin (a contributory factor in jaundice)

Nutritions in mother milk

1. Mother milk is rich in vitamins, minerals and other nutrients as well as trace elements.

2. Mother milk is alive, it contains digestive enzymes and live immune cells.

Health Benefits

Lowered risk of sudden infant death syndrome (SIDS)

Increased intelligence

Decreased incidence of ear infections and dental problems

Lowered risk of diabetes, childhood leukemia and asthma

Decreased risk of psychological disorders

Cow’s milk does not contain sufffcient vitamin E, Iron and essential fatty acids, which can cause

anemic.

Cow’s milk contains excessive protein, sodium and potassium, which may put a strain on

infant’s immature kidneys and infants experiences difficulty in digesting cow’s milk

“All matter originates and exists only by virtue of a force...

We must assume behind this force the existence of a conscious and intelligent Mind.

This Mind is the matrix of all matter.”

……. Max Planck

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Acorus calamus

Acorus calamus (Sweet flag)

“Pediatric medicine” – a brain tonic

Botanical name : Acorus calamus

Family : Araceae

Vernacular names

Sanskrit: Haimavathi, Vacha

Hindi: Bajai, Gora-bach, Vasa

Tamil: Vasambu

Malayalam: Vayambu

Kannada: Baje

Medicinal uses

1. The decoction prepared from vasambu and liquorice (athimathuram) is given for pediatric

ailments like cough, fever pain in the abdomen etc.

2. The rhizome is burnt and the ashes are mixed with coconut oil and applied over the lower

abdomen for flatulance.

3. Traditionally the new born child is given vasambu and the main intention to give this

medicine is proper brain devolopment, speech ability, better visual power, increased

seminal power, brings beauty and neutralises any toxicities in our body.

4. The powder of this rhizome if consumed daily in the dose of 100 to 700 mg is very

beneficial for strengthening the nervous system. It should be noted that a dose above 1

gram may lead to vomitting.

5. The powder of vasambu is mixed with honey and given internally for fitz. During this

treatment if only milk is given internally then the results will be more effective.

6. To prevent epilepsy in children this rhizome is prepared as an amulet and tied in the body

of the child preferably waist.

Acorus calamus is also found to possess anti-oxidant, diuretic, anti-microbial and anti-

inflammatory activities.

Extract of Acorus calamus rhizomes also exhibited significant anti-inflammatory effect in

experimental animals like acute and chronic models which was observed to be well comparable

with that of the reference drugs like hydrocortisone, phenylbutazone etc.

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Eribulin

Eribulin- a new drug to treat breast cancer. Eribulin is a synthetic ketone analogue of the marine

sponge halichondrin B, natural mitotic inhibitor found in Japan’s pacific coast.

Mechanism of action

Acts as a unique inhibitor of microtubule dynamics, binding predominantly to a small

number of high affinity sites of microtubules.

Eribulin exerts its anticancer effect by triggering apoptosis and irreversible mitotic blockade,

blocks cell division and forms toxic components for the tumor cells.

Eribulin, first drug iimproves the survival rate 20 % without combining with any other drugs

and shows minor toxicity than any other chemotherapeutics.

Side effects

Neutropenia, anemia, leucopenia, peripheral neuropathy on discontinuation of treatment,

asthenia, alopecia and constipation

Only the man of serene mind can realise the spiritual meaning of life.

Honesty with oneself is the condition of spiritual integrity.”

SarvepalliRadhakrishnan

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Azelastine

Azelastine is a potent second generation, selective histamine antagonist

Mode of action

Azelastine has a triple mode of action

Anti-histamine effect

Mast -cell stabilizing effect

Anti-inflammatory effect

Indication

Azelastine nasal drops are indicated for allergic rhinitis

Azelastine eye drops are indicated for allergic conjunctivitis

Pharmacokinetics

Azelastine has rapid onset of action;

15 minutes with nasal spray

3 minutes with eye drops

Effect last for 12 hours

N

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CH3

దేశం ఎటు పో త ంది ఈ దేశం , ఏమ ై పో త ంది ఈ దేశం

బ ంబుల దాడిక ితటుు కోలేక శమశానానికి పరుగెడుత ందా...

మత కలహాలు భర ంచలేక తల దించు కుంటుందా

ఆపాాయత కరువ ందని అవమాన పడుత ందా ...

దిన దినం ఒక గండంతో గటటు కకలేక పో త ంది

క్షణ క్షణం భయంతో అటుడుకు ఒదిగ పో త ంది ఏమ ై పో త ంది మన

దేశం ....

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Januvia - anti diabetic agent

A new anti diabetic drug Sitagliptin phosphate (Januvia ) has been approved by USFDA for the

management of type 2 diabetes. This lowers blood sugar level by blocking DPP-4 enzyme.

Mechanism of action

DPP-4 is responsible for the breakdown of proteins, which stimulates the insulin producing cells

after a meal. So by inhibiting DPP-4 insulin level can be maintained, and it prolongs the release

of insulin.

Dose

100 mg once a day and adjusted based on renal function.

Need not be taken along with meal, as other classes of anti-diabetics

Drug interaction

Observed with tenor in – beta blocker, MAOIs, bactrim, NSAIDs and probenecid.

Side effects

Sore throat and head ache

…… Consider yourself as a humble mite in the world, an equal only to

your brethren and above all endear yourself to the supreme power by your purity

Sir CV Raman

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CENTRE FOR HUMAN EXCELLENCE

50th

centre of SWAMI VIVEKANANDA CENTRE FOR HUMAN EXCELLENCE is established

in GRCP, campus. On 5th

March, Saturday 2011, Swami Bodhamayanandaji, Director, Vivekananda

Institute of Human Excellence, Sri Ramakrishna Math, Domalguda, Hyderabad inaugurated the center

and delivered the key note address. Dr CVS Subrahmanyam Principal, Gokaraju Rangaraju College of

Pharmacy presided the function and Sri KSN Raju Sr Administrative officer Gokaraju Rangaraju

college of Engineering and Technology, delivered the address. Dr A Ramakrishna Prasad Director I/c,

University Industry Interaction Cell, JNTU-H, Kukatpally, Hyderabad was the guest of Honour and

given a talk.

…… All the powers in the universe are already ours. It is we who have put

our hands before our eyes and cry that it is dark..

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AICTE sponsored National level workshop on

Optimization Techniques in Pharmaceutical Formulations

GRCP organized 3 days National level workshop on “Hands on Training on Optimization techniques

in Pharmaceutical Formulations” from 24-26th

Feb 2011 at GRCP. The main objective of the workshop

was to bring together researchers, academicians and students to discuss optimization techniques,

design of experiments (DOE) in the development of formulations. Prof PR Satheesh Babu, convenor

arranged all the necessities. Prof Dr CVS Subrahmanyam, Prof K Bhadraya, Prof Dr Madhusudan Rao,

Prof KSK Rao Patnaik, Prof Dr PR Sathish Babu, Mr I Jagadeesh and Mrs N Monika were the

resource persons of the workshop. The experts covered BOX Benken design, Plaket_Burman design,

factorial design, fractional factorial designs, composite designs, EVOP and REVOP and matrix and

simplex designs. About 60 delegates from various from all over the india participated and gained

knowledge.

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ECO FRIENDLY LIFE ADAPTATION CAMPAIGN

With that idea WOW organized ECO FRIENDLY LIFE ADAPTATION CAMPAIGN, which was

held at NTR garden and Necklace road and the same was organized in college campus also. Andhra

Prabha – telugu daily news paper witnessed the activity.

Global warming refers to an average increase in the Earth's temperature, which in turn causes changes

in climate. A warmer earth may lead to changes in rainfall patterns, a rise in sea level, and a wide

range of impacts on plants, wildlife, and humans.

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WOW activities

At Swami Vivekanada Orphanage

Home, Warangal, AP

At Lourdhu Madha Divya Karunya Ashram, Hyderabad