Clinical study – University of Bologna, Italy In vitro and in vivo evaluation of the effectiveness of three dentine desensitizing treatment regimens Several clinical trials have demonstrated GLUMA Desensitizer’s effective and long-lasting reduction of dentine hypersensitivity. The following study confirms as well the efficacy of GLUMA Desensitizer PowerGel in reducing dentine hypersensitivity. GLUMA ® Desensitizer PowerGel Giving a hand to oral health. Scientific Information
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Clinical study – University of Bologna, ItalyIn vitro and in vivo evaluation of the effectiveness of three dentine desensitizing treatment regimens
Several clinical trials have demonstrated GLUMA Desensitizer’s effective and long-lasting reduction of dentine hypersensitivity. The following study confirms as well the efficacy of GLUMA Desensitizer PowerGel in reducing dentine hypersensitivity.
ObjectiveTo evaluate the in vitro and in vivo effects of 3 different treatments on dentine permeability and reduction of dentine hyper-sensitivity.
Materials & MethodsThe desensitisation treatments were: GLUMA Desensitizer PowerGel, MS Coat One (Sun Medical) and dentine burnishing with fiber-resin burs. A split-chamber device was used to investigate the permeability of dentine slices cut from human molars in vitro. Fluid flow through dentine was recorded with a photochemical method after EDTA cleaning, albumin soaking and desensitisa-tion treatment (n = 10). 61 study participants with three severely hypersensitive teeth each were recruited. Sensitivity was determined with an air stimulus before, immediately after treatment, and after 6 months, using a verbal rating scale.
Results
52 out of 61 patients were available for the 6-month recall. All treatments reduced fluid flow through dentine (P > 0.05). All treatments reduced dentine hypersensitivity significantly. Statistical results revealed significant differences among the treatments (P = 0.03). Statistical analysis revealed that GLUMA Desensitizer PowerGel and the fiber-resin bur led to a superior hypersensitivity reduction than MS Coat One.
ConclusionBoth the topical desensitiser applications and the dentine burnishing treatment were effective in reducing dentine hyper-sensitivity for 6 months. GLUMA Desensitizer PowerGel and dentine burnishing with fiber-resin burs showed consistently high reduction in sensitivity. Whereas teeth treated with the oxalate containing MS Coat One regained some sensitivity over time.
CommentGLUMA Desensitizer PowerGel is very effective in reducing cervical dentine hypersensitivity.
SourceDondi Dall’Orologio et al.: In vitro and in vivo evaluation of the effectiveness of three dentine desensitizing treatment regimens. Am J Dent, 2014, 27:139-144.The study was abbreviated, summarised and commented and all diagrams and titles have been established by Kulzer.
Clinical study – University of Bologna, Italy In vitro and in vivo evaluation of the effectiveness of three dentine desensitizing treatment regimens
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GLUMA Desensitizer PowerGel leads to an effective reduction of dentine hypersensitivity directly after application and up to 6 months
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no discomfort (0) slight discomfort (1) severe discomfort during stimulation (2)