Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure elements as well as irregular regions. Note: the vast majority of proteins are globular.
Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.
Dec 21, 2015
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Globular Proteins
Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure elements as well as irregular
regions.
Note: the vast majority of proteins are globular.
Ribbon Diagram Showing Secondary Structures in a Globular Protein
Some Globular Protein Structures
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
Myoglobin
Hemoglobin(complex of 4 polypeptide chains or subunits)
Triose phosphate isomerase (complex of 2 subunits) 20S Proteasome (complex of 28 subunits)
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Additional Elements of Structure: Turns
turns turn
R2 often Pro
R2 often Pro
Most common type of turn
R3 never Pro
R3 never Pro
trans-Pro (above) or cis-Pro (in Type VI turns) often found in turns, but rarely in helices and sheets.
Turns with cis-Proline: Type VI
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
Type VIa
Type VIb
cis-trans Isomerization of Proline Residues
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
Peptidyl-prolyl cis-trans isomerases accelerate the isomerization.
Additional Elements of Structure: Loops
•Irregularly structured elements•More disordered and flexible than turns•Connects secondary structure elements•Variable in length and shape•Frequently form binding sites and enzyme active sites
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
The N- and C-terminal arms of proteins are also generally more disordered and irregularly structured.
Domain and Motifs in Globular Proteins: Supersecondary Structure
Some Common Motifs Found in Proteins
motif
hairpin
motif
barrelsbarrel
Related Documents
