www.indiabusinessreports.com Global Stem Cell Market Technology & Global Market Opportunity Sector: Pharma / Healthcare Services May 2014
Nov 23, 2015
www.indiabusinessreports.com
Global Stem Cell Market
Technology & Global Market Opportunity
Sector: Pharma / Healthcare Services
May 2014
Index
What are Stem Cells? 3
Types of Stem Cells and their Relative Merits 8
Status of Stem Cell R&D 16
Global Stem Cell Market Size 23
Leading Global Stem Cell Companies 30
Indian Stem Cell Companies 42
Deals in Stem Cell Space 45
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What are Stem Cells?
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Stem Cell Definition
Stem cells are fundamental, basic, or undifferentiated cell of a multi-cellular organism. They are capable of being transformed or grow into indefinitely manifold cells of the same type, and from which, other kinds of cell can be grown, by differentiation
Stem cells are at the center of a new field of science called Regenerative Medicine.
Since stem cells can become a bone, muscle, cartilage and other specialized types of cells, they have the potential to treat many diseases, including Parkinson's, Alzheimer's, diabetes and cancer. They may also be used to regenerate organs / skin, reducing the need for organ
transplants and related surgeries.
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Types of Stem Cells
There are three broad categories of stem cells
Embryonic stem cells
Embryonic stem cells include those found within the embryo, the fetus or the umbilical cord blood. Depending upon when they are harvested, embryonic stem cells can give rise to just about any cell in the human body.
Adult / Tissue stem cells
Adult stem cells can be found in infants, children and adults. They reside in already developed tissues such as those of the heart, brain and kidney. They usually give rise to cells within their resident organs.
Induced pluripotent stem cells (IPSC)
These stem cells are adult, differentiated cells that have been experimentally "reprogrammed" into a stem cell-like state.
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Why Interest in Stem Cells
Increase understanding of how diseases occur
By watching stem cells mature into cells that eventually become bones, heart muscle, nerve cells, and other organs and tissue, researchers and doctors will have better understanding how a variety of diseases and conditions develop.
They have the ability to generate healthy cells to replace diseased cells (regenerative medicine)
Researchers believe that they can train stem cells into becoming specific cells so that those specialized cells can be used to regenerate and repair diseased or damaged tissues in people.
Test new drugs for safety and effectiveness.
Before using new drugs in people, researchers could use stem cells to test the safety and quality of investigational drugs.
For instance, nerve cells could be generated in order to test a new drug for a nerve disease. Tests could show whether the new drug had any effect on the cells and whether the cells were harmed.
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Stem Cell Market Business Segmentation
Stem cell market can be segmented in four segments
Stem Cell Products
Adult stem cell, cord blood cells, human embryonic cells and other
Stem Cell Services
Stem cell banking, stem cell acquisition and testing, drug discovery and target identification, isolation / characterisation services, and molecular biology
Stem Cell Technologies
Stem cell production, cryopreservation, expansion and sub-culture
Stem Cell Applications
Regenerative medicine neurological disorders, orthopedics, cancer hematological disorder, incontinence, and drug development
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Type of Stem Cells and Their Relative Merits
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Popular Sources of Stem Cells
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11%
33%
5%5%6%
11%
17%
6%6%
Cell Type
Adipose
Bone Marrow
Embryonic
Epithelial
Fibroblasts
Source: www.seekingalpha.com
Type of Stem Cells and Their Current Uses Snap Shot
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Type Source Their capability
Current researches
Clinic readiness?
Advantages Limitations
Embryonic StemCells
Early stage embryo called a blastocyst
Make all the different types of cells in our body
Understanding how our bodies develop from a fertilized egg; Investigating how to produce different types of specialised cell
The first clinical trials are now beginning, focussed on treating eye disorders; these are early stage safety trials
Can produce all the different types of cells in the body . Can self-renew (copy themselves) almost forever, so large supplies can be made
Still learning how to fully control differentiation of these cells. Some concerns on ethical or religious grounds
Tissue stem cells (e.g. skin, blood)
Tissues of the adult body
Make only the types of cells that belong in their own tissue, e.g. skin stem cells make only types of skin cells, they do not make brain or blood cells
Understanding how adult tissues are made and maintained Improving our understanding of diseases affecting adult tissues, including cancer
Skin and blood stem cells have been in use for a number of years for skin grafts and bone marrow transplants
Already partly specialised, which can make it more straightforward to obtain the particular specialised cell type required
How to multiply, control and use different types of tissue stem cells. Treatments for blood diseases, severe burns and some types of corneal damage have been proven; no other treatments are yet proven.
Type of Stem Cells and Their Uses Snap Shot
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Type Source Their capability
Current researches
Clinic readiness? Advantages Limitations
Umbilical Cord Blood Stem Cells
The umbilical cord after the birth of a baby
Make the different types of cells found in the blood
Understanding how blood stem cells work
Mainly used to treat children with blood disorders, primarilyleukaemia; although adults can sometimes be treated, this is limited because only a small number of stem cells can be obtained from a cord
Can be frozen and stored
Need to know how to multiply cord blood stem cells. Only proven uses are for blood disorders; studies suggesting these cells can be used to make non-blood-related types of cells have not been widely reproduced Cord blood must be matched to the patient to avoid rejection.
Mesen-chymalstem cells (a type of tissue stem cell)
Bone marrow Make cells of the skeletal tissues: bone, cartilage, fat Support blood stem cells to make new blood cells
Understanding how these cells contribute to making and maintaining tissues
Clinical trials are underway for cartilage & bone repair, for aiding repair of blood vessels after heart attacks, and for other unrelated treatment
Already partly specialised, which can make it more straightforward to obtain the particular specialised cell type required
How to multiply, control and use different types of tissue stem cells. Treatments for blood diseases, severe burns and some types of corneal damage have been proven; no other treatments are yet proven.
Type of Stem Cells and Their Uses Snap Shot
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Type Source Their capability
Current researches
Clinic readiness? Advantages Limitations
Induced Pluripotentstem cells (iPS cells)
Made in the lab from specialized adult cells, for example skin cells
Behave very like embryonic stem cells make all types of cells in the body
Can be made from patients and used to produce cells that act as a model disease in the laboratory for studying diseases and testing new drugs
Not yet Could provide patient-specific treatment
Not yet established how reprogramming works . Properties of cells need further comparison with embryonic stem cells As with ES cells, we are still learning how to fully control these cells to ensure they make the cells we want in a way that will be safe for clinical use
Diseases Curable by Cord Blood Stem Cells
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Cancer Blood Disorders Immune Disorders Metabolic Disorders
1. Acute Leukemia2. Chronic Leukemia3. High-Risk Solid
Tumors4. Hodgkin & Non-
Hodgkin Lymphoma (types of blood cancers)
5. MyelodysplasticSyndromes *
1. Aplastic Anemia2. Beta Thalassemia3. Diamond-Blackfan
Anemia4. Fanconi Anemia#5. Sickle Cell Disease
1. Chronic Granulomatous@ Disease
2. Hystiocytic Disorders$3. Leukocyte Adhesion
Deficiency%4. Severe Combined
Immunodeficiency Diseases
5. Wiskott-Aldrich Syndrome^
1. Krabbe Disease&2. Hurler Syndrome+3. Metachromatic
Leukodystrophy4. Sanfilippo Syndrome
* Syndromes involving ineffective production of the myeloid class of blood cells. Patients with MDS can develop severe anemia and require blood transfusions# A genetic defect in a cluster of proteins@ A genetic disorder in which certain immune system cells are unable to kill some types of bacteria and fungi$ Histiocytic disorders are a group of diseases that occur when there is an over-production of white blood cells known as histiocytes that can lead to organ damage and tumor formation% A rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections^ WiskottAldrich syndrome is a rare X-linked recessive disease characterized by eczema, thrombocytopenia, immune deficiency, and bloody diarrhea& Krabbe disease is a rare, often fatal degenerative disorder that affects the myelin sheath of the nervous system.+ Hurler syndrome is a genetic disorder due to a deficiency of alpha-L iduronidase, an enzyme responsible for the degradation of mucopolysaccharides in lysosomes Hurler syndrome is a genetic disorder due to a deficiency of alpha-L iduronidase, an enzyme responsible for the degradation of mucopolysaccharides in lysosomes
Diseases Curable by Adult Stem Cells
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Cancer Cancer Auto-Immune Disorders
Anemias/Blood Conditions
1. Brain Cancer2. Retinoblastoma3. Ovarian Cancer4. Skin Cancer:
Merkel Cell Carcinoma
5. Testicular Cancer6. Tumors abdominal
organs Lymphoma7. Non-Hodgkins
lymphoma8. Hodgkins
Lymphoma9. Acute
Lymphoblastic Leukemia
10. Acute MyelogenousLeukemia
11. Juvenile MyelomonocyticLeukemia
12. Cancer of the lymph nodes
13. Multiple Myeloma14. Myelodysplasia15. Breast Cancer16. Neuroblastoma17. Renal Cell Carcinoma18. Various Solid Tumors19. Soft Tissue Sarcoma20. Waldenstrom's
macroglobulinemia21. Hemophagocytic
lymphohistiocytosis22. POEMS syndrome
1. Multiple Sclerosis2. Crohn's Disease3. Scleromyxedema4. Scleroderma5. Rheumatoid Arthritis6. Juvenile Arthritis7. Systemic Lupus8. Polychondritis9. Sjogren's Syndrome10. Behcet's Disease11. Myasthenia12. Autoimmune
Cytopenia13. Systemic vasculitis14. Alopecia universalis
1. Sickle cell anemia2. Sideroblastic anemia3. Aplastic Anemia4. Amegakaryocytic
Thrombocytopenia5. Chronic Epstein-Barr
Infection6. Fanconi's Anemia7. Diamond Blackfan
Anemia8. Thalassemia Major9. Red cell aplasia10. Primary
Amyloidosisme
Diseases Curable by Adult Stem Cells
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Wounds/Injuries Neural Degenerative Diseases/Injuries
Immunodeficiencies Other Metabolic Disorders
1. Limb gangrene2. Surface wound
healing3. Jawbone
replacement4. Skull bone repair
1. Parkinson's disease2. Spinal cord injury3. Stroke damage
1. X-Linked hyper immunoglobuline-M Syndrome
2. Severe Combined Immunodeficiency Syndrome
3. X-linked lymphoproliferativesyndrome
1. Osteogenesisimperfecta
2. Sandhoff disease3. Hurler's syndrome4. Krabbe Leukodystrophy5. Osteopetrosis6. Cerebral X-linked
adrenoleukodystrophy
Other diseases that can be cured are repairing heart damage and corneal regeneration
Status of Stem Cell R&D
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Stem Cell therapies At the Cusp of Emerging
The cell therapy sector, is currently engaged in over 1,900 clinicaltrials around the world. This includes more than 300 clinical trialsbeing sponsored by approximately 250 companies developingcommercial products for almost every imaginable disease orcondition.
In 2012, the sector garnered over $900 million in investmentfrom private investors and public markets, and over $300 millionfrom grant sources aggregating an approximate $1.2 billion ininvestment.
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Global Pharma investing in Regenerative Med
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100% of the companies interviewed in ARMs Pharma and Biotech Survey are investing in regenerative medicine
Key therapeutic opportunities
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Industry sees Wound and Burns as the biggest opportunity area, followed by neuro, autoimmune, ocular and cardio vascular diseases
Stem cell based new drug candidates the key focus
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69% of the companies have invested in cellular-based regenerative medicine products
Over 50 late stage trials
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Cancer, Musculo skeletal , and non healing wounds would see a spate of new products
Korea leads Asia in stem cell research pipeline
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Global Stem Cell Market Size
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Over 100 cell therapy products in the market currently
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Wound care products are a large share
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Non healing wounds, and skin are almost half the productsThe first of these products, Apligraf, was brought to market in 1998.In the past five years there have been 12 approvals: United States (six), Europe (one), Canada (one), New Zealand (one), and South Korea (three).
Source: ARM
Small market size currently; immense potential ahead
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In 2013, Regenerative Medicines surpassed $1 billion in annualrevenue, with over 160,000 patients receiving treatment
In addition, over 60,000 stem cell transplants annuallyperformed worldwide for the treatment of oncology and blood-based disorders
The potential savings from regenerative medicine treatmentsfor the United States alonein terms of reducing the direct costsassociated with chronic diseases have been estimated atapproximately $250 billion a year.
Stem Cell Business Opportunity Global
According to Axis Research Mind, global stem cell market was estimated to be $ 21 billion in 2010
Estimated to reach $ 60 billion by 2015
North America constitutes 60% of the global market, however its the Asian market which is growing faster
Asian markets are estimated to grow at 25% CAGR during the period 2010-2015
In the Asian region, Japan, China, Singapore, Korea and Australia are the major hubs for stem cell research
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Umbilical Cord Blood Business Opportunity Global
Allied Market Research estimates that the global umbilical cord blood stem cell market is forecasted to reach market value over $11.5 billion in 2014 from $ 6.5 billion in 2012
Developments and approvals for novel cord blood stem cells therapies is expected to drive the market growth.
The market is expected to reach revenue of $56.4 billion by 2020, growing at CAGR of 33.4%during 2013 to 2020.
The stem cell storage service market was valued at $7.4 billion in 2013
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Indian stem cell banking market
Cord Blood Stem Cell Banking has emerged as new opportunity of healthcare services provider in Indian market. The market is still in nascent stage of development and valued around US$ 60 Million in 2013 and further expected to surpass US$ 400 Million by 2018. The current cord blood stem cell preservation level for new born baby is below 1% and hence there exists immense opportunity for cord blood stem cell preservation service providers to grow exponentially in coming years.
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Key Global Companies in Stem Cell Market
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A vibrant market
They are developing:
cell-based therapies, smallmolecules, biologics, tissue-engineered cells and materials andimplantable devices
drug discovery or toxicity testing toolsas well as clinical tools, bioprocessingtools and platforms that includeequipment, consumables, reagentsand storage systems
The field also incorporates a variety ofservice companies specializing inclinical trialmanagement, manufacturing, engineering and financing among others.
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Alliance for Regenerative Medicine (ARM) estimates there are over 700 companieswith a regenerative medicine focus ranging from divisions of multinationalcorporations to smaller organizations focused solely on the sector.
Listed Therapeutic Companies
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Several listed stem cell companies. All are still in investment mode, with R&D spends much higher than revenue Most of them have products in Phase II or later stages
Company Name Market Cap Revenue (2013)
R&D Exp EBITDA Net Income Employees Founded
1 Mesoblast Inc 1,460.1 32.6 40.1 -55.8 -57.7 76 2004
2 Osiris Therapeutics Inc 444.5 24.3 5.0 -2.8 -1.1 70 1992
3 Neuralstem, Inc., 355.2 0.1 7.1 -12.5 -19.8 15 1996
4 Pluristem Therapeutics Inc 235.4 0.7 17.2 -22.2 -21.2 160 2001
5 Athersys, Inc. 225.3 2.4 20.5 -24.5 -30.7 56 1995
6 NeoStem, Inc 197.2 14.7 16.9 -36.8 -40.0 108 1980
7 Cytori Therapeutics, Inc 187.9 12.2 17.1 -30.7 -26.2 115 1996
8 Fibrocell Science, Inc 165.0 0.2 12.6 -30.5 -30.0 58 1995
9 TiGenix NV 161.5 5.9 15.0 22.1 -25.4 19 2000
10 Advanced Cell Technology 161.0 0.2 11.6 -29.7 -30.6 38
11 Invivo Therapeutics Holdings Corp 120.9 - 10.5 -19.0 -38.8 70 2005
12 StemCells, Inc 71.5 1.2 20.5 -28.6 -26.4 58 1988
13 Cytomedix, Inc. 68.1 11.6 3.8 -18.1 -20.2 40 1987
Source: Stem Cell Stock Index, finance.yahoo.com
Mesoblast( Aus): Worlds leading stem cell company
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Set up in 2004. Did an IPO in Dec04. Raised $175mn in Mar13, via a private placement Acquired the entire culture-expanded mesenchymal stem cell (MSC) business of Osiris Therapeutics in
Oct13. Acquired US company Angioblast in 2010 at A$250mn valuation Has 110 patents now
Stem Cells working with 4 types Mesenchymal Precursor Cell; Cultureexpanded Mesenchymal Stem Cells; Dental Pulp Stem Cells; Expanded
Hematopoietic Stem Cells
Therapeutic areas 10 leads across 4 areas: Inflammatory, Spine, Cardio and Onco Phase III CHF (n=1700) (partnership with Teva) Phase III spinal fusion (expected 2014) Phase III Prochymal in GvHD and Crohns Disease Degenerative Disc Disease (expected PIII in 2014) Phase II type II diabetes Phase II Rheumatoid Arthritis Phase II Macular degeneration
Alliances Teva: To commercialise adult cells for degenerative conditions of the cardio and CNS Lonza: To ensure commercial scale-up, COGS reduction and clinical manufacturing JCR Pharmaceuticals (Japan): For use of MSCs in Graft versus Host disease programmes in children and adults
Osiris, USA
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Founded in 1992, did IPO in 2006 Developed the worlds first approved stem cell drug, remestemcel-L (brand name
Prochymal) for graft versus host disease, which got approval in Canada Sold Prochymal to Mesoblast in 2013 in a deal worth $100mn + royalties. Sold Biosurgery product Osteocel to Nuvasive, Inc. in 2008 for ~$80 million Now focussed on Biosurgery: wound care, orthopedic and sports medicine markets. Has 3 commercial products, focussed on developing revenues. In 2014, for the first time in
the companys history, commercial investments will exceed R&D investments From inception in December 1992 through December 31, 2013, Osiris has incurred
aggregate research and development costs of approximately $436 million
Stem Cells Was using Adult Bone Marrow cells for Prochymal Current products based on human tissue
Curent Therapeutic areas Grafix: Diabetic foot ulcers and burns Ovation: Wound healing Ovation OS: Bone repair Cartiform: Cartilage restoration
Neuralstem, USA: Leader in Neural Stem Cell Science
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Founded in 1996, listed in 2006 Raised $20mn in Jan14, has warrants outstanding for a similar amount Neuralstem is growing regionally specific cells that are already suited to the task prescribed
to them once transplanted into the CNS 15 U.S. patents re-affirmed worldwide technology and product; 9 pending
Stem Cells Patented technology for isolation and expansion of Neural stem cells
Curent Therapeutic areas Amyotrophic Lateral Sclerosis (ALS): Phase II trials commenced in Sep13 Ischemic Stroke: Phase II trials commenced in Dec13 Spinal Cord Injury: Phase I trials expected to commence in Apr14 Multiple Sclerosis, Optic Neuritis, Alzheimers Disease: In pre-clinical phase
Pluristem, Isreal: Leader in placenta based cell science
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Founded in 2001, listed in 2007 28 granted patents and over 100 pending applications globally
Stem Cells Utilizes PLacental eXpanded (PLX) mesenchymal like adherent stromal cells Treatment of a
variety of inflammatory and ischemic conditions
Therapeutic areas has around 20 products in its pipeline spanning Cardio 5 products Ortho 2 products Pulmonary 2 products Womens health 1 product Hematology 4 products CNS 3 products
Alliances With United Therapeutics, Inc for a Pulmonary Hypertension product. Has already
received $7mn upfront payment, and in line to receive $55mn milestone payments With CHA Bio & Diostech, a Korean company, for CLI trials and 50:50 JV in S Korea
Athersys, USA
Founded in 1996, went public through reverse merger in 2007 and raised $ 65 mn Funded by firms like Radius Ventures, OrbiMed Advisors, MPM BioEquities and others
Over 130 issued patents (including RM and other areas)
Stem Cells
Developing MultiStem, a patented, adult-derived off-the-shelf stem cell product platform
Therapeutic areas - multiple disease indications in the areas of
inflammatory and immune
neurological
cardiovascular disease.
Alliances
Development & commercialisation partnerships with Bristol-Myers Squibb (BMS), AngiotechPharma and Pfizer
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Several promising unlisted companies
Organogenesis, USA: Largest by revenue
With $100mn revenue in 2011, largest regenerative company in the world
Founded in 1985, listed in 1986, went private in 2002
Got FDA approvaal for flagship product Apligraf in 1998, ahead of its time
Acquired Dermagraft from Shire Plc in Jan14 for staged payments upto $300mn
Stem Cells
Apligraf is a matrix of cow collagen, human fibroblasts and keratinocyte stem cells (from discarded circumcisions)
Therapeutic Areas
Wound healing (Apligraf)
Oral regeneration (Gintuit)
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Gamida (Isreal): Leader in stem cell expansion tech
Has developed a large number of platform technologies to expand functional cell populations
Backed by strategics and venture funds: Elbit Imaging, Clal Biotechnology Industries, Israel Healthcare Venture, TevaPharma, Amgen, Denali Ventures and AurigaVentures
Stem Cells
UCB stem cells
Therapeutic Areas
Blood cancer, solid tumours, autoimmune and metabolic disorders
Its lead product StemEx is in Phase III for treatment for bone marrow transplant for blood cancer, and will be launched soon
Stem Cell Banks
China Cord Blood Corporation: Largest Chinese Stem Cell Bank
Chinas leading provider of cord blood collection, laboratory testing, hematopoietic stem cell processing, and stem cell storage services
Listed on NYSE in 2009, when it raised $20mn. Leading US PE fund KKR invested $65mn in CCBC in Apr12
Business profile
Accumulated subscriber base reached 359,487 by Dec13
Under PRC government regulations, only one licensed cord blood bank is permitted to operate in each licensed region and only seven licenses have been authorized as of today
The only operator with multiple licenses, with access to 4* of the 7 authorized licenses. It has its own centres in Beijing, Guangdong, and Zhejiang; and holds equity in another bank
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Stem Cell Banks
Cordlife Group, Singapore
The first cord blood bank to be set up in Singapore (May 2001)
Listed on Singapore Exchange Main Board on 29 March 2012
Has done aggressive investments recently. The Group acquired 10% equity in China Cord Blood Corporation, one of the top operators in China. It also accquired 32% stake in StemLifeBhd, Malaysia. It also acquired parts of Asian business of Australias Cordlife Limited.
Business profile
Owns and operates full processing and cryopreservation storage facilities across Asia, namely in Singapore, Hong Kong, India, Indonesia and The Philippines
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Service Companies
Hope Medical Group, China
Group of five hospitals in China certified by The Chinese Ministry of Health to provide adult stem cell and Cancer immunotherapy treatments for local and global patients.
The Hospitals are Wuxi Peoples Hospital, Jiangsu: 1870 beds. It is also Ministry of Health stem cell technical training base
Marys Orthopedic Hospital, Beijing: 260 beds, focusses on stem cell treatment in bone & cartilage injuries; bone coloboma & bone non union; ischemic necrosis of femoral head; osteoarthritis; Erbs disease; neck, back pain caused by Intervertebral Disc Degeneration etc.
Beijing Zhenguo Tumor Rehabilitation Hospital: 300 beds, focusses on cancer and tumour
Guangzhou Cancer Center: 1000 beds
Hengyang Stem cell and cancer center: 1500 beds, offers Hemopoietic stem cell transplantation
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Leading Indian Companies
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Key Indian Players and their Focus in Sub-Sectors of Stem
Cell Segment
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Company Profile Banking Research Product
Reliance Life Sciences
It has in-house capabilities in research, development, commercial manufacturing, sales & marketing. The company is developing products in the domain of regenerative medicine (stem cell therapies, tissue engineered products, stem cell enriched repository services, assisted reproduction)
Cord Blood Repository offering both public and family banking services
Regenerative medicine range of novel autologus and allogenic cell therapies and tissue engineered products
ReliNethra: Autologus limbalstem cell composite graft
CardioRel:Autologus cardiomyocytes
LifeCell LifeCell is Indias first & largest private stem cell bank and stem cells solutions provider. The company has a technological collaboration with CRYO-CELL International Inc. the worlds first and largest stem cell bank
Umbilical cord blood & cord tissue; menstrual blood cell banking
TRICell Therapeutics: Research in autologus bone marrow for the treatment of nonreconstructable critical limb ischemia; allogenic cord blood infusion in patients with Type I diabetes; burns and wound healing etc.
Key Indian Players and their Focus in Sub-Sectors of Stem
Cell Segment
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Company Profile Banking Research Product
CryobanksIndia
Founded in 2006, the company is a JV between CryobanksInternational USA and RJ Corp,under the guidance of Dr. NareshTrehan (Medanta). Approved by US FDA
Umbilical cord blood stem cell banking
Cryobanks is conducting research on the use of stem cells for several therapy areas like Diabetes, Alzheimers, Multiple Sclerosis, Cariology etc.
Stempeutics The company is developing stem cell based medicinal products, with facilities in Bangalore, Manipal and Malaysia. The company has an alliance with Cipla for the marketing of its products. Its first product, for critical limb ischemia, is set to be commercialised soon
Derived from bone marrow
Stempeutics has 8 products in clinical trials, in Phase I and II stages. These are in the area of Cardiology, Diabetes, Osteo-arthritis, Liver and Critical Limb Ischemia
Stempeucel-CLI forcritical limb ischemia is now set for a Phase III trial and a launch after that soon
OCTTherapies & Research
OCT is currently working on its first product: a WJ-MSC based approach towards advanced would care. The company has filed for patent, and is currently doing animal trials
WJ-MSC Its first product is currently in animal tests. OCT aims to start Phase 1 within a year
For mild to severe burns, and chronic ulcers. It is a topical application
Deals: Acquistions / Funding / Partnerships
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Acquisitions and mergers
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When Acquirer Acquired Valuation ($mn) Key Assets
Apr'14 Neostem California Stem Cell Inc
n.a Melapuldencel-T, which targets cancer initiating cells for melanoma, will become NeoStem's most advanced product candidate. Will undergo
Phase III in 2014
Apr'14 Fate Therapeutics, Inc Verio Therapeutics Inc
n.a Developing drug candidates targeting the activation of endogenous stem cells
Mar'14 Intrexon Corporation Medistem, Inc n.a Pioneer in the development of Endometrial Regenerative Cells ("ERC" or "ERCs"), universal donor adult-derived stem cells with properties
uniquely suited for therapeutic use with Intrexon's existing suite of
synthetic biology technologies
Jan14 Organogenesis Dermagraft from Shire Plc
300 Shire Plc exited RM business it acquired in 2011 when it purchased Advanced BioHealing. Organogenesis has $100mn+ revenue from
Apligraf, and gets another $70mn from this deal, consolidating its No 1
position in the US advanced wound care market.
Oct'13 StemCells, Inc. Patents from Neurospheres
Holdings Ltd
n.a The portfolio broadly claims the manufacture and proliferation of purified populations of human neural stem cells and their use as therapeutics and
as tools for drug discovery
Apr'13 Stem Cell Therapeutics Corp
Trillium
Therapeutics IncMerger Immunotherapy and cancer stem cell research
Nov'12 Smith & Nephew plc Healthpoint Biotherapeutic
782 Bioactive debridement, dermal repair and regeneration wound care treatments
Jun'12 Royal DSM Kensey Nash 360 Biomedical equipment following advances in regenerative medicine and tissue engineering
Apr'12 Shire PLC Pervasis Therapeutics
200 Vascugel, a biodegradable implant containing human endothelial cells in Phase II testing to prevent hemodialysis vascular access failure in
patients with end-stage renal disease (ESRD)
Feb'12 Cytomedix Inc Aldagen Inc 40 Regenerative therapies for wound care, inflammation and blood vessel developmen
Jan'12 Mediware Information Systems Inc
Transtem LLC. Software for managing the collection and transplantation of adult stem
cells for cellular therapy and medical research
Oct'11 NeoStem Inc Amorcyte n.a AMR-001, a stem cell treatment being evaluated for the treatment of acute myocardial infarction
PE deals
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When Investor Target Deal Size
($mn)
Country
Dec'13 Special Situations Funds, Ridgeback Capital, Merlin Nexus, Sabby Capital, venBio, Opaleye
Management and HSMR Advisors.
Stem Cell Therapeutics
Corp30 USA
Nov'13 Sheridan Legacy Group Progenicare n.a USA
Aug'13Ballast Point Ventures and River Cities Capital
Funds TissueTech Inc. 10USA
Jul'13 Wales Life Sciences Investment Fund ReNeuron 20 Wales
Feb'13Helion Lifecell International Pvt
Ltd 7 India
Apr'12KKR China Cord Blood Corp
65 China
Jul'11
Johnson & Johnson Development Corp.,
Sanderling Ventures and Asset Management Co.
Viacyte Inc
11 USA
Apr'11
Tactics II Stem Cell Ventures, Sam Zell's Equity
Group Investments LLC, Sixth Floor Investors LP
and G Force Investments LLC
Cellular Dynamics
International, Inc
30 USA
Apri'11 PBM Capital Group, L.P GigaCyte n.a USA
Disclaimer
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