Evolving roles of universities in knowledge integration and economic growth Seoul, Korea Nov 6, 2013
Jul 28, 2015
Evolving roles of universities in knowledge integration
and economic growth
Seoul, Korea Nov 6, 2013
Evolving roles of universities
in knowledge integration and economic growth
Seoul, Korea Nov 6, 2013
Evolving roles of universities in knowledge integration
and economic growth
Seoul, Korea Nov 6, 2013
• Academic Community • Start-up Community
Academia and the Problems of Society
Academia Society
Problems*
• Energy
• Pollution
• Water
• Poverty
• Disease
• Aging
• Global Warming
• War
• Women’s rights
• Intolerance
*Wicked problems
Agriculture
Immunology Metabolism
Microbiology
Academic knowledge is fragmented
Economics Chemical
engineering
Cell biology
Neurology
Ecology
Surgery
Stem cell biology
Molecular biology
Political science
Need to integrate across academic
boundaries to solve global
problems
CITRIS (UCB, UCD, UCM, UCSC) Center for Information Technology Research in the Interest of Society
QB3 is one of the Four California Institutes for
Science and Innovation created by the State to
integrate across interfaces
CAL-(IT)2 (UCSD, UCI) Institute for Telecommunications and
Information Technology
QB3 (UCB, UCSC, UCSF)
California Institute for Quantitative Bioscience
CNSI (UCLA,UCSB) California Nanosystems Institute
Integrating Academic Knowledge
The Wicked Problems
• QB3 is a scientific network that integrates the research efforts of its three campuses
Public funds
QB3 Labs
Research Education
QB3 and the Integration of Knowledge
Academia Society
Problems*
• Energy
• Pollution
• Water
• Poverty
• Disease
• Aging
• Global Warming
• War
• Women’s rights
• Intolerance
*Wicked problems
Economics Chemical
engineering
Agriculture
Cell biology
Immunology Metabolism
Neurology
Microbiology
Ecology
Surgery
Stem cell biology
Molecular biology
Political science
QB3 and the Integration of Knowledge
Academia Society
Problems*
• Energy
• Pollution
• Water
• Poverty
• Disease
• Aging
• Global Warming
• War
• Women’s rights
• Intolerance
*Wicked problems
Economics Chemical
engineering
Agriculture
Cell biology
Immunology Metabolism
Neurology
Microbiology
Ecology
Surgery
Stem cell biology
Molecular biology
Political science
$500M
QB3 and the Integration of Knowledge
Academia Society
Problems*
• Energy
• Pollution
• Water
• Poverty
• Disease
• Aging
• Global Warming
• War
• Women’s rights
• Intolerance
Rejuvenation Therapies
Consortium
Economics Chemical
engineering
Agriculture
Cell biology
Immunology Metabolism
Neurology
Microbiology
Ecology
Surgery
Stem cell biology
Molecular biology
Political science
The QB3 Rejuvenation Therapies Consortium
Stem Cells Chronic
inflammation
Metabolic
disorders Neuro-
endocrinology
Vasculature
System
Exercise
Tissue Repair
Post-operative
Cognitive
disorder
Cell Repair
Systems Biology
Human
Genetics
Interventions
The QB3 Rejuvenation Therapies Consortium
Stem Cells Chronic
inflammation
Metabolic
disorders Neuro-
endocrinology
Vasculature
System
Exercise
Tissue Repair
Post-operative
Cognitive
disorder
Cell Repair
Systems Biology
Human
Genetics
Interventions
Rejuvenation by mouse parabiosis
• Blood from young mouse rejuvenates muscle, liver, skin and hippocampus of old mouse by restoring replicative capacity to progenitor cells
Rejuvenation by Removing Senescent Cells
• Delete p16 expression (+AP) in progeria mouse; inhibit aging.
HMGB1 + ?
Fracture
Postop Cognitive Decline
Cytokine release
Glial activation
LTP disruption Bone Surgery
Experimentally Induced Cognitive Decline
TNF-α
Neuroinflammation
Hippocampus
Aging trigger Aging response
Lose Quality Control
•DNA, protein & organelle repair
•Tissue remodeling (innate
immunity)
•Initiate reproductive phase
Accelerate Degradative Paths
•Humans- senescent stem cells &
chronic inflammation
•C. elegans – somatic cell death
Consortium View
Modulators
•Wounds, infection, obesity
•Vascular leak
•Diet & Exercise
•Hypothalamic activity
•Blood borne signals
Integrating Academic Knowledge
The Wicked Problems
• QB3 is a scientific network that integrates the research efforts of its three campuses
Public funds
QB3 Labs
Research Education
Society problems
Private sector
Public funds
Existing Companies
New Companies
QB3 Labs
Research Education
QB3 Innolab
The Wicked Problems
Creating a Bio-economy
• Discard old models of partnership
• Network industry and academic scientists for society benefit
Private sector
Public funds
Existing Companies QB3 Labs
Research Education
QB3 Innolab
The Wicked Problems
Creating a Bio-economy
Public funds
New Companies
QB3 Labs
Research Education
QB3 Innolab
The Wicked Problems
Creating a Bio-economy
Tools Start-up in a Box
Support in incorporating, launching and SBIR funding
InnoLab Start-up Program
Goal: best biotech start-up community in America
Creating a Bio-economy
140 companies
incorporated in 2 years
Tools Start-up in a Box
Community Workspace
Low cost, high quality lab space near university
Support in incorporating, launching and SBIR funding
InnoLab Start-up Program
Goal: best biotech start-up community in America
Creating a Bio-economy
140 companies
incorporated in 2 years
62 present tenants, 15 graduates,
400 jobs, $2.5M/year/
company,
Hewlett Packard Garage
Start-up in a Box
Community Workspace
Low cost, high quality lab space near university
Support in incorporating, launching and SBIR funding
InnoLab Start-up Program
Goal: best biotech start-up community in America
Creating a Bio-economy
140 companies
incorporated in 2 years
62 present tenants, 15 graduates,
400 jobs, $2.5M/year/
company,
QB3@953: new 24,000sq ft incubator
Tools
Start-up in a Box
Community Workspace
Low cost, high quality lab space near university
Support in incorporating, launching and SBIR funding
InnoLab Start-up Program
Goal: best biotech start-up community in America
Creating a Bio-economy
140 companies
incorporated in 2 years
62 present tenants, 15 graduates,
400 jobs, $2.5M/year/
company,
QB3@953: new 24,000sq ft innovation workspace
Tools
QB3@953
Tools Start-up in a Box
Community Workspace
Mission Bay Capital
Seed funding for QB3 equity
Low cost, high quality lab space near university
Support in incorporating, launching and SBIR funding
InnoLab Start-up Program
Goal: best biotech start-up community in America
Creating a Bio-economy
140 companies
incorporated in 2 years
62 present tenants, 15 graduates,
expanding to ~100,
400 jobs, $2.5M/year/
company,
$11.3M from LPs, 11 companies,
prestigious advisory board
Tools Start-up in a Box
Community Workspace
Mission Bay Capital
Seed funding for QB3 equity
Low cost, high quality lab space near university
Support in incorporating, launching and SBIR funding
InnoLab Start-up Program
Goal: best biotech start-up community in America
Creating a Bio-economy
140 companies
incorporated in 2 years
62 present tenants, 15 graduates,
expanding to ~100,
400 jobs, $2.5M/year/
company,
$11.3M from LPs, 11 companies,
prestigious advisory board
Luke Evnin, PhD
Managing Director
MPM Capital
Ralph (Chris) Christoffersen, PhD
Partner
Morgenthaler Ventures
Brook Byers
Partner
Kleiner, Perkins, Caufield & Byers
Brian Atwood
Managing Partner
Versant Ventures
John Wadsworth, Jr.
Managing Director
Manitou Ventures
Fred Cohen, M.D., Ph.D.
General Partner TPG Ventures
and Professor, UCSF
Bill Ericson
Partner
MDV
Advisory Board
Tools Start-up in a Box
Community Workspace
Mission Bay Capital
Seed funding for QB3 equity
Low cost, high quality lab space near university
Support in incorporating, launching and SBIR funding
Collaborative
Start-ups
Industry co-investors
Creating a Bio-economy
140 companies
incorporated in 2 years
62 present tenants, 15 graduates,
expanding to ~100,
400 jobs, $2.5M/year/
company,
$11.3M from LPs, 11 companies,
prestigious advisory board
Roche, Bayer, J&J, Novartis
InnoLab Start-up Program
Goal: best biotech start-up community in America
Evolution of a Community
QB3 Innovation Workspace
Industry
Venture
Services
Govt. Agencies
International Partners
QB3 BioInnovation Ecosystem Start-up Companies
Private Sector
Investors
Universities
Governments • improved health • economic growth
• public service mission • equity return
• deal flow • de-risking
• technology • M&A • Services income
• market/regulatory expertise • Co-investment • Affiliation fees
• management • seed funding
• discoveries • biological expertise
• Research support • QB3 support
A University-anchored Bioeconomy Community