“GLOBAL HEALTH CRISES CAUSED BY THE COLLISION OF BIOLOGICAL AND CULTURAL EVOLUTION: PRE-NATAL INFLUENCES ON ACUTE AND CHRONIC DISEASES LATER IN LIFE” Prof. James E. Trosko Department of Pediatrics/Human Development College of Human Medicine & Prof. Reza Nassiri Institute International Health College of Osteopathic Medicine Michigan State University East Lansing, Michigan 48824 E-mail: [email protected]
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Global Health Crises Caused By The Collision Of Biological And Cultural Evolution: Pre-Natal Influences On Acute And Chronic Diseases Later In Life
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“GLOBAL HEALTH CRISES CAUSED BY THE COLLISION OF BIOLOGICAL AND CULTURAL EVOLUTION: PRE-NATAL INFLUENCES
ON ACUTE AND CHRONIC DISEASES LATER IN LIFE”
Prof. James E. TroskoDepartment of Pediatrics/Human
DevelopmentCollege of Human Medicine
&
Prof. Reza Nassiri Institute International Health
College of Osteopathic Medicine
Michigan State UniversityEast Lansing, Michigan 48824
THE GLOBAL HEALTH PROBLEM• Currently there are 7 Billion people on Earth. By the end of this Century, Earth will have 3
billion more babies.
• Earth’s physical environment (water, air, Global Warming) is being Irreversibly altered.
• Earth’s Bio-ecosystem, as it relates to human food supply, is stressed (Crop failures,new microbial invasions,etc.).
• Human biological adaptive genome, acquired slowly over millions of years by biological evolution, is becoming stressed by the laser-speed changes in our cultural evolution, by the food/diets that are changing. This includes changes in the human gut microbiome.
• Currently, the limited health care resources, devoted towards the Global Health Crisis, is via “crisis medicine” [dealing with the Metabolic Diseases, e.g., diabetes, cardiovascular diseases, cancer, dementia, which are, in large part, caused by bad diets/nutrition] are insufficient to meet the needs of these adult chronic diseases.
• Diethylstilbestrol (DES)- induction of human vaginal cancers
• Bis-Phenol A induction coat color & obesity in rats
• Soy product reduction of breasts, breast cancer and induction of osteoporesis. Facts of the study of the atomic bomb survivors.
• C. Lau, eta., Fetal Programming of Adult Diseases .Obstetrics & Gynecology 117: 978-985, 2011
David Parker: Fetal Experience Affects Chronic Diseases later in Life
C.M. Powers, Tox Sci 134: 225-242, 2013
BARKER HYPOTHESIS: IN UTERO EXPOSURES & RISKS TO DISEASES LATER IN LIFE
BREAST CANCER NEWSBREAST CANCER NEWS
• Genistein & Bowman-Birk Inhibitor as Bioactive Components of Soy Products
Hsieh CY,& Chang, C.C. “Stem Cell Differentiation and Reduction as a Potential Mechanism for Chemoprevention of Breast Cancer. Clin Pharm J. 51: 15-30, 1999. [ and inducer of osteoporoses]
Panel A. Solvent control; Panel B Cholera Toxin-Positive Control; Panel C. Genistein (10-7 M); and Panel D. Vitamin D3. 12 days after treatment.
Induction of Differentiation of Human Adult Breast Stem Cells
THE TROSKO HYPOTHESISTHE TROSKO HYPOTHESIS
Alteration of organ-specific stem cells by environmental pollutants, stress, nutrition, and
drugs can modify the risk to stem cell-based diseases later in life