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    Oleh:

    dr. M. Dzikrifishofa

    Oleh:

    dr. M. Dzikrifishofa

    Global Initiative for Asthma

    RSUD Demang Se!la! Ra"a

    #ovember $%&'

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    G

    I#

    A

    G

    I#

    A

    lobal

    itiative for

    sthma

    lobal

    itiative for

    sthma

    Global Initiative for Asthma

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    Definition of AsthmaDefinition of Asthma

    Asma adalah gangguan inflamasi kronik saluran

    napas yang melibatkan banyak sel dan elemennya

    menyebabkan peningkatan hiperesponsif yangmenimbulkan gejala episodik berulang berupa

    mengi, sesak napas, dada terasa berat dan batuk-

    batuk terutama malam dan atau dini hari. Episodik

    tersebut berhubungan dengan obstruksi jalan napasyang luas, bervariasi dan seringkali bersifat

    reversibel dengan atau tanpa pengobatan.

    Asma adalah gangguan inflamasi kronik saluran

    napas yang melibatkan banyak sel dan elemennya

    menyebabkan peningkatan hiperesponsif yangmenimbulkan gejala episodik berulang berupa

    mengi, sesak napas, dada terasa berat dan batuk-

    batuk terutama malam dan atau dini hari. Episodik

    tersebut berhubungan dengan obstruksi jalan napasyang luas, bervariasi dan seringkali bersifat

    reversibel dengan atau tanpa pengobatan.

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    Source: Peter J. Barnes, MD

    Asthma Infammation: Cells andMediators

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    Asma merupakan masalah kesehatan

    masyarakat yang serius di berbagai negara di

    seluruh dunia. Asma diperkirakan terdapat pada300 juta penduduk diseluruh dunia.

    Asma merupakan masalah kesehatan

    masyarakat yang serius di berbagai negara di

    seluruh dunia. Asma diperkirakan terdapat pada300 juta penduduk diseluruh dunia.

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    Factors that Exacerbate AsthmaFactors that Exacerbate Asthma

    Allergens

    Respiratory infections

    Exercise and hyperventilation

    Weather changes

    Sulfur dioxide Food additives drugs

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    Factors that !nfluence Asthma

    Development and Expression

    "ost Factors

    #enetic

    $ Atopy $ Air%ay

    hyperresponsiveness

    #ender

    &besity

    "ost Factors

    #enetic

    $ Atopy $ Air%ay

    hyperresponsiveness

    #ender

    &besity

    Environmental Factors !ndoor allergens

    &utdoor allergens &ccupational sensiti'ers (obacco smo)e Air *ollution Respiratory !nfections Diet

    Environmental Factors !ndoor allergens

    &utdoor allergens &ccupational sensiti'ers (obacco smo)e Air *ollution Respiratory !nfections Diet

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    !s it Asthma+!s it Asthma+

    Episode mengi berulangBatuk di malam hari

    Batuk atau mengi setelah latihanBatuk, mengi atau sesak dada setelahterpapar alergen udara atau polutan

    Batuk lebih dari 10 hari

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    Asthma Diagnosis

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    (ksaserbasi asmaMild or moderate

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    (stimate )omarative Dail" Dosages for

    Inhaled Gl!*o*orti*osteroids b" Age

    (stimate )omarative Dail" Dosages for

    Inhaled Gl!*o*orti*osteroids b" Age

    Dr!g +o, Dail" Dose -g Medi!m Dail" Dose -g /igh Dail" Dose -g

    0 1 " Age 2 1 " 0 1 " Age 2 1 " 0 1 " Age 2 1 "

    Dr!g +o, Dail" Dose -g Medi!m Dail" Dose -g /igh Dail" Dose -g

    0 1 " Age 2 1 " 0 1 " Age 2 1 " 0 1 " Age 2 1 "

    3e*lomethasone $%%41%% &%%4$%% 01%%4&%%% 0$%%4'%% 0&%%% 0'%%

    3!desonide $%%45%% &%%4$%%

    5%%4&%%% 0$%%4'%% 0&%%% 0'%%

    3!desonide4#ebInhalation S!sension

    $1%41%%

    1%%4&%%% 0&%%%

    )i*lesonide 6% 7 &5% 6%4&5% 0&5%48$% 0&5%48$% 08$%4&$6% 08$%

    9l!nisolide 1%%4&%%% 1%%41%

    0&%%%4$%%% 01%4&$1% 0$%%% 0&$1%

    9l!ti*asone &%%4$1% &%%4$%% 0$1%41%% 0$%%41%% 01%% 01%%

    Mometasone f!roate $%%4'%% &%%4$%%

    0 '%%46%% 0$%%4'%% 06%%4&$%% 0'%%

    ;riam*inolone a*etonide '%%4&%%% '%%46%%

    0&%%%4$%%% 06%%4&$%% 0$%%% 0&$%%

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    Waktu kontrol

    sustain step up

    short time step up

    dayto day

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    Asthma Management and *revention *rogram

    Se*ial )onsiderationsAsthma Management and *revention *rogram

    Se*ial )onsiderations

    Special considerations are re,uired to

    manage asthma in relation to-

    *regnancy

    Surgery Rhinitis sinusitis and nasal polyps

    &ccupational asthma

    Respiratory infections #astroesophageal reflux

    Aspirin$induced asthma

    Anaphylaxis and Asthma

    Special considerations are re,uired to

    manage asthma in relation to-

    *regnancy

    Surgery Rhinitis sinusitis and nasal polyps

    &ccupational asthma

    Respiratory infections #astroesophageal reflux

    Aspirin$induced asthma

    Anaphylaxis and Asthma

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