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>gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR QGTRILIDMVKKIQRKFPRWTRDQQLKGGISAYNAGVGNVRSYERMDIGTLHDDYSNDVVARAQYFKQHGY
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>gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

May 01, 2015

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Michele Crippa
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Page 1: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

>gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR QGTRILIDMVKKIQRKFPRWTRDQQLKGGISAYNAGVGNVRSYERMDIGTLHDDYSNDVVARAQYFKQHGY

Page 2: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 3: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 4: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 5: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 6: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 7: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Matrici empiriche di sostituzione

Page 8: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 9: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 10: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

destrorsa

sinistrorsa

Page 11: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 12: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 13: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 14: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 15: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 16: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 17: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 18: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 19: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 20: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Le chaperonine possono assistere il ripiegamento delle proteine

Page 21: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Proteine di membrana

alfa-eliche barile beta

Page 22: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Le eliche trans-membrana sono prevedibili con grafici di idropatia

Page 23: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Distribuzione dei residui polari e idrofobici nelle proteine di membrana

GLUT1 trasportatore del glucosio

Page 24: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Funzioni delle proteine di membrana

• Trasporto

• Ricezione e trasmissione di segnali

• Produzione di energia

• Reazioni enzimatiche

Page 25: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Proteine fibrose

alpha cheratinadoppia elica

Page 26: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Alterazione “permanente” della cheratinaHS-

-S

-S

-S

-S

-S

-S

S-

S-

S-

S-

S-

S-

-SH

-SH

-SH

-SH

-SH

-SH

HS-

HS-

HS-

HS-

HS-

HS-

HS-

HS-

HS--SH

-SH

-SH

-SH

HS- HS-

HS-

HS-

-S

-S

-S

-S

-SH -SH

riduzione piega ossidazioneS-

S-

S-

HS-

S-

HS-

Page 27: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Collagene:

tripla elica ricca in idrossiprolina

Page 28: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Fibroina (seta): foglietti beta molto compatti - ricca in Glicina e Alanina

Page 29: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Proteine globulari

Page 30: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 31: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.

Motivi comuni nelle strutture delle proteine

Page 32: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.
Page 33: >gi|47825389|ref|NP_001001470.1| lysozyme [Gallus gallus] MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLSYCGVRASRTIAERDLGS MNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGLMQVDKRYHKIEGTWNGEAHIR.