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Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department of Mathematics, UC Berkeley QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Mary-Lee Dequéant Olivier Pourquié QuickTime™ TIFF (Uncompre are needed to
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Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

Dec 21, 2015

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Page 1: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

Geometry of Rank TestsFundamentals for Finding Somitogenesis Clock Genes

Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand

Department of Mathematics, UC Berkeley

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Mary-Lee DequéantOlivier Pourquié

QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.

Page 2: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.
Page 3: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.
Page 4: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

QuickTime™ and aTIFF (Uncompressed) decompressor

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From Willbrand et al., 2005

Rank Tests

A rank test is a map

Page 5: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

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123 132

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Page 6: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

123 132

213

231 321

312

+-

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-+

Page 7: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Page 8: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

QuickTime™ and aTIFF (Uncompressed) decompressor

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Page 9: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

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Page 10: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

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Page 11: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

Graphical Models

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Page 12: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

A set of conditional independence triples is a semi-graphoid if the following axiom holds:

Theorem: The map is a bijection between convex rank tests and semi-graphoids. 123 132

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Page 13: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

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Page 14: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

Graphical Models = Graph Associahedra

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Page 15: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.
Page 16: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

QuickTime™ and aTIFF (Uncompressed) decompressor

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Thanks again to Profs. Strømme, Ranestad, Rudakov and Smaløe.

Page 17: Geometry of Rank Tests Fundamentals for Finding Somitogenesis Clock Genes Jason Morton, Lior Pachter, Anne Shiu, Bernd Sturmfels, Oliver Wienand Department.

Thanks again to Profs. Strømme, Ranestad, Rudakov and Smaløe.