Genome-Wide Association Study and Whole Genome Selection for Resistance to Bovine Respiratory Disease in Pre-Weaned Holstein Calves using Thoracic Ultrasonography Allison Quick, Terri Ollivett, Brian Kirkpatrick, Kent Weigel University of Wisconsin - Madison 1
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Genome-Wide Association Study and Whole Genome Selection for … · 2021. 1. 14. · Genome-Wide Association Study and Whole Genome Selection for Resistance to Bovine Respiratory
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Genome-Wide Association Study and Whole Genome Selection for Resistance to Bovine Respiratory Disease in Pre-Weaned Holstein
Calves using Thoracic Ultrasonography
Allison Quick, Terri Ollivett, Brian Kirkpatrick, Kent Weigel
▪assembly of succinate dehydrogenase, an enzyme complex also referred to as respiratory complex II
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▪ TSHZ3:
▪up-regulating miRNAs during metritis events
▪myogenesis in muscle structure affecting fat infiltration
▪smooth muscle formation
▪ EGR2:
▪required for the development and maintenance of myelin structure and function
▪abnormalities of the gene in humans lead to restrictive pulmonary disease, recurrent pneumonia, and respiratory failure▪DAGLA and FEN1:
▪nervous, immune, respiratory, metabolic systems
▪FEN1: poor survival of stage-I lung adenocarcinoma in humans
Top Genomic Regions
Phenotype 𝛔𝐠𝟐 (SE) 𝛔𝐞
𝟐 (SE) 𝐡𝟐
CON3 0.027 (0.010) 0.100 (0.010) 0.214
BRD3 0.036 (0.013) 0.112 (0.012) 0.241
CON6 0.012 (0.010) 0.136 (0.011) 0.084
BRD6 0.018 (0.018) 0.144 (0.012) 0.111
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Genetic Parameter Estimates
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CON3
BRD6
CON6
BRD3
GEBV GEBV
Nu
mb
er
of
An
imal
sN
um
be
r o
f A
nim
als
Distributions of Predicted Breeding Values
Nu
mb
er
of
An
imal
sN
um
be
r o
f A
nim
als
GEBV GEBV
▪ Scoring protocol allowed objective, efficient assessment of BRD phenotypes to build a genomic reference population
▪ GWAS identified regions containing putative genes with functions related to respiration and immunity
▪ Moderate heritability estimates suggest potential for achieving genetic progress in reducing the incidence of BRD
▪ 3-week phenotypes gave higher heritabilities due to smaller influence of management and chance pathogen exposure
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Summary of Our Project
Practical Implementation
▪ Calf health GPTAs now available from Zoetis
▪ Respiratory disease at various ages
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Vukasinovic et al., 2018
Age of Calf# Genotyped
CalvesSD of GPTAs (%) Mean REL (%)
0 to 3 d 220,571 2.51 50.1
4 to 14 d 202,946 1.65 41.7
15 to 50 d 198,900 2.23 42.3
51 to 365 d 212,895 2.50 38.1
0 to 365 d 212,201 3.01 40.1
▪ Calf Wellness (CW$) index is now available from Zoetis
▪ 8% relative weight in Dairy Wellness Profit Index (DWP$)
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Vukasinovic et al., 2018
TraitRelative Weight in
Calf Wellness (CW$) Index
Respiratory Disease 29%
Livability 43%
Scours 28%
▪ Selection tools to improve dairy calf health are overdue
▪ Zoetis offers genomic predictions for calf scours, livability, and respiratory disease via farmer-reported health events
▪ Thoracic ultrasound offers an objective assessment of lung consolidation that can be implemented very efficiently
▪ Future research should focus on expanding the genomic reference population and developing systems to assess elite young bull and heifer calves in genetic nucleus herds
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Overall Conclusions
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Questions?
Funded by Hatch Grant 142-AAA3859 from the United States Department of Agriculture