8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
1/44
22101
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
2/44
22102
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
3/44
22103
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
4/44
22104
Purines
Adenine = 6-amino purine
Guanine = 2-amino-6-oxy
purine
Hypoxanthine = 6-oxypurine
Xanthine = 2,6-dioxypurine
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
5/44
22105
Pyrimidines
Uracil = 2,4-dioxypyrimidine
Thymine = 2,4-dioxy-5-methyl pyrimidine
Cytosine = 2-oxy-4-
amino pyrimidine Orotic acid = 2,4-
dioxy-6-carboxypyrimidine
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
6/44
22106
Medical relevance of nucleotide
pathwaysCritical in cancer treatment
Hydroxyurea, anti-folates, FdUMP, 5-FU, etc
Antiviral therapies
acyclovir and herpes
Important inborn errors and pathologies
Adenosine deaminase and SCIDS
Lesch-Nyhan Syndrome
Hyperuricemia
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
7/44
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
8/44
22108
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
9/44
22109
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
10/44
221010
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
11/44
221011
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
12/44
221012
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
13/44
221013
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
14/44
221014
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
15/44
221015
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
16/44
221016
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
17/44
221017
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
18/44
221018
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
19/44
221019
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
20/44
221020
Lesch-Nyhan syndrome
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
21/44
221021
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
22/44
221022
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
23/44
221023
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
24/44
221024
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
25/44
221025
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
26/44
221026
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
27/44
221027
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
28/44
221028
Orotic aciduria
an inherited human disease caused by adeficiency in the multifunctional enzymethat catalyzes the last 2 steps in the
pyrimidine synthesis large amounts of orotic acid in urine retarded growth and severe anemia
treat by administration (injection) of uridineand/or cytidine
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
29/44
221029
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
30/44
221030
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
31/44
221031
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
32/44
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
33/44
221033
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
34/44
221034
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
35/44
221035
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
36/44
221036
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
37/44
221037
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
38/44
221038
CLINICAL SIGNIFICANCE
6-Mercaptopurine Inhibits PRPP Amidotransferase, IMP DHASE,Adenylsuccinate synthase
5-Fluorouracil(FUTP) Inhibit maturation of r,m RNA(FdUMP) Inhibits thymidylate synthase
Methotrexate Inhibits H2 folate reductase.Azaserine : Inhibits enzymes that utilize gln as N doners(Gln antagonists)6-Diazo-5-oxo-1-norleucine: (Gln antagonists)Hydroxyurea: Inhibits ribonuleotide reductase.
3-azido-3-deoxythymidine -AZT :antiviral-chain termination(pyr analog)
Acycloguanosine- Acyclovir: "( pur. Analog)
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
39/44
221039
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
40/44
221040
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
41/44
221041
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
42/44
221042
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
43/44
221043
8/8/2019 Genetics, Lecture 1 &2 Purines & Pyrimidines (Slides)
44/44
221044