Genetics 210: Personalized Medicine and Genomics FOR: MDS, PHDS AND CURIOUS STUDENTS SPRING TERM. TUE 2:15 – 4:05 THUR. 2:15-4:05 GENOTYPING : $15 COPAY GENE210.STANFORD.EDU: INFO AND FAQS
Apr 01, 2015
Genetics 210: Personalized Medicine and Genomics
FOR: MDS, PHDS AND CURIOUS STUDENTS
SPRING TERM. TUE 2:15 – 4:05 THUR. 2:15-4:05
GENOTYPING : $15 COPAYGENE210.STANFORD.EDU: INFO AND FAQS
Today
Course overview (~30’)Informed consent (~30’)How to get genotyped (~10’)Questions (~15’)
Course Staff
Course Organizers: Stuart Kim (Dev. Bio., Genetics) Aaron Gitler (Genetics) Rosalind Chuang (Neurology)
TAs: Andrew Roos (Epidemiology) Thomas Roos (Epidemiology)
Published Genome-Wide Associations
Genetics 210: Personalized Medicine and Genomics
DiabetesHeart DiseaseCancer Alzheimer’s, Parkinson’s/Huntington’s
Human Ancestry
Height prediction
How much Neanderthal are you?
Neanderthal George Church, Harvard Geneticist
Stuart
All time record
Joint Genotyping Task Force2008-2010
Charles Prober Dean Hank Greely Law SchoolRuss Altman Genetics C. Braddock Med SchoolPat Brown Biochem. Gil Chu BiochemMike Grecius Neur. Sean David Med. SchoolCarlos Bustamente Gen. Harry Greenberg DeanRalph Horwitz Psych Louanne Hudgins EpiAnne James Legal Counsel Jesse Karmazin Med. SchoolStuart Kim Dev. Bio. Mark Krasnow BiochemPhil Lavori HRP David Magnus Cen. BMEKelly Ormond Genetics Alan Schatzberg Psych.Mike Snyder Genetics Atul Butte BMIKeyan Salari Med. School Mildred Cho Pediatrics
Personal Genotyping
Voluntary. You can use a public genome file instead of your own.
Confidential – instructors will not know who opted to be genotyped.
Private – Your own DNA information will not be revealed.
Counseling - genetic counseling via 23andMe and medical/psychological counseling via Dr. Alan Schatzberg (Psychology, Stanford).
Introductory Projects
Report on specific genetic locus. Published on SNPedia.com
Class room debate on FDA legislationUnanticipated opportunities that arise as you
explore your genome
Advanced Projects = (project + final)
Annotate whole-genome for Stuart Kim or Aaron Gitler (adopted)
Write a grant for Kaiser-Permanente GWAS (n=110,000)
Analyze exome sequence data from ALS patients
Write an algorithm for choosing minimal n number of people to sequence to get all sequence data in a population
Gene210
Three ManuscriptsTextbookPatentGrantiPhone App
in the news Chicago Medicine Magazine (story on page 18) Salon Web Magazine (9/2013) Stanford Medicine - DNA testing improves learning (8/13) San Jose Mercury News (5/2013) Time (2/2013) Nature USA Today San Francisco Chronicle Recap San Francisco Chronicle Genome Technology Stanford Press Release Nature Blogs LA Times Blog Genome Web Center for Genetics and Society Scientific American
Exploring Personal GenomicsAvailable at Amazon.com
How to get genotyping kits1. ATTEND THIS INFORMATION SESSION.2. MAKE CHECK $15 TO STANFORD.3. BRING CHECK TO KATHY FISHER IN
BECKMAN B300.4. FILL OUT INFORMED CONSENT FORM5. BRING SAMPLES BACK TO KATHY B3006. WE WILL SHIP THE GROUP OF
SAMPLES BACK TO COMPANY TUESDAY 4PM FEB. 4
7. RESULTS IN 6 -8 WEEKS.8. CLASS STARTS TUESDAY APRIL 1 ,
2012 .
https://www.23andme.com/user/claim/