Genes & Developmentgenesdev.cshlp.org/content/suppl/2012/01/25/26.2... · 3500 3520 3540 3560 3580-4 4 4 2 0-2 3500 3520 3540 3560 3580 4 2 0-2-4 spac16e8.01 spac16e8.02 spgna1 spac16e8.04c

% 0 5 10 25 50 75 90 95 100

Dist to EE (bp) 0 278 444 1,236 3,178 6,740 10,891 13,376 26,764

Dist to EL (bp) 349 578 1,142 2,355 2,836 5,575 8,633 10,259 13,685

Dist to LE (bp) 49 241 295 577 1,553 2,896 5,286 7,105 11,398

Dist to LL (bp) 25 112 415 1,272 2,898 5,011 8,265 9,552 23,881

0 5,000 10,000Distance to summit (bp)

Den

sity

Close to early

Close to late

0 2,000 10,000

0.00

010

0.00

020

0.00

030

0.00

000

Distance from Rif1 G1/S summits to origins

Distance to summit (bp)8,0006,000 12,000-2,000 4,000

Hayano_Supplemental Fig 9


Den

sity

0.00

005

0.00

010

0.00

015

0.00

020

0.00

025

0.00

000

Distance from Rif1 M-phase summits to origins

Close to EEClose to EL

Close to LLClose to LE

−100 −50 0 50 100

−20

24

6

Profiles around Rif1 G1/S EE binding sites

Position around peak summit (x 50 bp)

Log−

ratio

sig

nal /

inpu

t

Rif1 G1/S profileRif1 M phase profileori-hsk1ts profileRif1 G1/S EE summit

−30 −20 −10 0 10 20 30

02

46

Profiles around Rif1 G1/S EL binding sites


Log−

ratio

sig

nal /

inpu

t

Rif1 G1/S profileRif1 M phase profileori-hsk1ts profileRif1 G1/S EL summit

−100 −50 0 50 100

−20

24

68

Profiles around Rif1 G1/S LE binding sites


Log−

ratio

sig

nal /

inpu

t

Rif1 G1/S profileRif1 M phase profileori-hsk1ts profileRif1 G1/S LE summit

−100 −50 0 50 100

−20

24

68

Profiles around Rif1 G1/S LL binding sites


Log−

ratio

sig

nal /

inpu

t

Rif1 G1/S profileRif1 M phase profileori-hsk1ts profileRif1 G1/S LL summit


3500 3520 3540 3560 3580-4

4

4

2

0

-2

3500 3520 3540 3560 3580

4

2

0

-2

-4

SPAC16E8.01SPAC16E8.02

spgna1

SPAC16E8.04cSPAC16E8.05cSPAC16E8.06c

SPAC16E8.07c


SPAC16E8.10cSPAC16E8.11c

SPAC16E8.18SPAC16E8.12c

SPAC16E8.13

SPAC16E8.14c


SPAC16E8.17c

SPAC1B1.01

SPAC1B1.02cSPAC1B1.03c

SPAC1B1.04c

bsu1

SPAC17A2.02cSPAC17A2.03c

SPAC17A2.04c

SPAC17A2.05

SPAC17A2.06cSPAC17A2.07cSPAC17A2.08c

SPAC17A2.15

SPAC17A2.09c

SPAC17A2.10c

SPAC17A2.11SPAC17A2.12

SPAC17A2.13c

SPAC17A2.14

SPAC17G6.02c

SPAC17G6.03

SPAC17G6.04c

3500 3520 3540 3560 3580

2

0

-2

-4

Mcm4 in rif1∆Early S (25mM HU)

Mcm4 in hsk1-89Early S (25mM HU)

Mcm4 in WildEarly S (25mM HU)

1500 1520 1540 1560 1580

4

2

0

-2

-4

SPBC11B10.08SPBC11B10.09

SPBC11B10.10c

shy1

mdm20

SPBC83.01

rpl37a-2SPBC83.03c

SPBC83.04SPBC83.05

SPBC83.06c

SPBC83.07SPBC83.08

SPBC83.09c

SPBC83.10

SPBC83.11SPBC83.12

SPBC83.13

SPBC83.14c

SPBC83.15

SPBC83.16cSPBC83.19c

SPBC83.17

SPBC83.18c

SPBC29B5.01

SPBC29B5.02cSPBC29B5.03c

SPBC29B5.04cSPBC27.01cSPBC27.02c

SPBC27.03SPBC27.04

SPBC27.05

SPBC27.06cSPBC28F2.01c

SPBC28F2.02SPBC28F2.03

SPBC28F2.04c

SPBC28F2.05c

SPBC28F2.06c

SPBC28F2.07

SPBC28F2.08c

SPBC28F2.09

SPBC28F2.10c


1500 1520 1540 1560 1580

4

2

0

-2

-4

1500 1520 1540 1560 1580

4

2

0

-2

-4




3300 3320 3340 3360 3380

4

2

0

-2

-4

SPBC20F10.07

SPBC20F10.08c


nep1

SPBC17D11.02cSPBC17D11.03c

SPBC17D11.04c

SPBC17D11.05SPBC17D11.06

SPBC17D11.07c


SPBC17D1.02

SPBC17D1.03c


SPBC17D1.06

SPBC17D1.07c

SPBC11C11.01SPBC11C11.02

SPBC11C11.03

SPBC11C11.04c

SPBC11C11.05

SPBC11C11.06c

SPBC11C11.12rpl18

SPBC11C11.08

rpl5b

SPBC3B8.13c


SPBC3B8.10c


dsd1


SPBC3B8.04c


3300 3320 3340 3360 3380

4

2

0

-2

-4

3300 3320 3340 3360 3380

4

2

0

-2

-4




Chromosome I

Chromosome II

Chromosome II


SPAC6F12.17

SPAC19E9.01c


SPAC57A10.02SPAC57A10.03

SPAC57A10.04

sgf11

1360

SPAC3H1.07

SPAC3H1.08c

SPAC3H1.09c

SPAC3H1.10SPAC3H1.11

SPAC3H1.12c

SPAC3H1.13

19601020 1040

SPAC139.01coac1

SPAC139.03

SPAC139.04c

SPAC139.05SPAC23C4.01

SPAC23C4.02SPAC23C4.03

SPAC23C4.05c

Mcm4 in hsk1-89G1/S (restrict temp.)

BrdU in WildEarly S (25mM HU)

Cdc45 in WildEarly S (25mM HU)

BrdU in rif1∆Early S (25mM HU)

Cdc45 in rif1∆Early S (25mM HU)

4

2

0

-2

-4

4

2

0

-2

-4

4

2

0

-2

-4

4

2

0

-2

-4

4

2

0

-2

-4

3380

rpl5b

SPBC3B8.13c


SPBC3B8.10c


dsd1


SPBC3B8.04c

SPBC405.04c

SPBC405.05SPBC405.06

SPBC405.07


SPBC609.03


31602820 2840

SPBC19C7.03

SPBC19C7.04c

SPBC19C7.05SPBC19C7.06

SPBC19C7.07cSPBC19C7.08c

SPBC19C7.09c

SPBC8E4.02cSPBP4G3.01

SPBP4G3.02

SPBP4G3.03SPBPB2B2.01

SPBPB2B2.02

4440 4460

4

2

0

-2

-4

4

2

0

-2

-4

4

2

0

-2

-4

4

2

0

-2

-4

4

2

0

-2

-4

Mcm4 in hsk1-89G1/S (restrict temp.)

BrdU in WildEarly S (25mM HU)

Cdc45 in WildEarly S (25mM HU)

BrdU in rif1∆Early S (25mM HU)

Cdc45 in rif1∆Early S (25mM HU)

Chromosome I

Chromosome II

2660

SPAC4F8.12c

SPAC4F8.11

SPAC4F8.10c

SPAC4F8.08

SPAC4F8.07c

SPAC4F8.06

mrpl28

SPAC4F8.04SPAC644.01c

mrpl40

did4


Dormant origins activated in checkpoint mutants or rif1∆

mrc1∆214

1135

14

cds1∆203

rif1∆217

154

34

15

23


Supplemental Table S1

strain genotype source

MS487 h+ ade6-M210 rif1::LEU2 This study

MS157 h- ade6-M216 hsk1::kanR w/pREP2-hsk1 This study

MS143 h- hsk1::kanR w/pREP2-hsk1 our stock

HM530 h- hsk1::kanR rif1::LEU2 w/pREP2-hsk1 This study

HM631 h- hsk1::kanR rif1::LEU2 mrc1::kanR w/pREP2-hsk1 This study

HM495 h+ h- hsk1::kanR mrc1-S604AT645AT653A-5flag-kanR

w/pREP2-hsk1 This study

HM642 h- h+ h- hsk1::kanR rif1::LEU2

mrc1-S604AT645AT653A-5flag-kanR w/pREP2-hsk1 This study

YM71 h- our stock

MS252 h- mrc1::kan our stock

KO147 h- hsk1-89:ura4 our stock

MS317 h- hsk1-89:ura4 mrc1::kanR our stock

FY14160 h- rif1::ura4 from NBRP (National Bioresource Project)

HM214 h+ hsk1-89:ura4 rif1::ura4 This study

FY14161 h- taz1::ura4 from NBRP (National Bioresource Project)

HM456 h+ hsk1-89:ura4 taz1::ura4 This study

HM646 h- hsk1-89:ura4 rif1::ura4 taz1::ura4 This study

FY14171 h- rap1::ura4 from NBRP (National Bioresource Project)

HM470 h+ hsk1-89:ura4 rap1::ura4 This study

KYP103 h- nda3-KM311 cdc21-3FLAG:kanR

aur:aur1r-Adh-TK-Adh1-scENT1 our stock

HM440 h- nda3-KM311 rif1::ura4 cdc21-3FLAG:kanR

aur:aur1r-Adh-TK-Adh1-scENT1 This study

FY14174 h90 rif1-12myc:ura4 rap1::ura4 from NBRP (National Bioresource Project)

HM605 h+ nda3-KM311 rif1-12myc:ura4 This study

HM621 h+ nda3-KM311 rif1-12myc:ura4 taz1::ura4 This study

HM651 h- nda3-KM311 rif1-12myc:ura4 cdc45-3flag:kanR This study

HM656 h- nda3-KM311 rif1-12myc:ura4 mcm4-3flag:kanR This study

HM634 h+ nda3-KM311 rif1::ura4 cdc45-3flag:kanR This study

Supplemental Table S1 List of the strains used in this study

All the strains are leu1-32 and ura4-D18.

Table S2

chromosome start end summit origin category ori ori

(Segrado et al., 2003) (this study)

WT rif1 D

chr1 12673 15525 14729 o LE

chr1 49260 50789 49881 LL

chr1 54035 54250 54222 LL

chr1 61185 63128 61689 o LE

chr1 63736 64347 63937 o LE

chr1 69685 70794 70154 o LE

chr1 71808 75898 72774 o LE

chr1 78151 81096 78976 o LE

chr1 84633 86830 85251 o LE

chr1 87471 88743 88177 o LE

chr1 94210 95561 94844 o LE

chr1 97034 97331 97305 o LE

chr1 107308 107926 107603 LL

chr1 111901 113101 112489 o o EE AT1015

chr1 123961 124867 124334 o o EE

chr1 129424 130146 129767 LL

chr1 149071 149223 149100 LL

chr1 151096 151684 151384 o LE

chr1 152563 153360 153023 o LE

chr1 164478 165876 165512 LL

chr1 187951 188348 188128 LL

chr1 189675 190572 190190 LL

chr1 198723 200036 199560 o o EE

chr1 201518 201850 201683 o o EE

chr1 202990 203764 203446 o o EE

chr1 239879 241199 240857 o LE

chr1 243297 244421 243898 o LE

chr1 255136 255333 255254 LL

chr1 272261 272871 272534 LL

chr1 293912 294752 294362 o LE

chr1 298902 299420 299101 o LE

chr1 301404 302566 301861 o LE

chr1 311617 312275 311909 LL

chr1 319100 320108 319527 LL

chr1 325600 326706 326146 o LE

chr1 338104 338397 338181 LL

chr1 356863 357242 357162 LL

chr1 363988 365146 364585 o o EE

chr1 391248 391665 391494 LL

chr1 409889 411389 410468 o LE

chr1 425624 426062 425769 LL

chr1 433407 434038 433786 LL

chr1 439964 440992 440403 o o EE

chr1 445541 446197 445829 o LE

chr1 455820 456523 456166 LL

chr1 463381 464200 463819 o LE

chr1 473093 473906 473475 o LE

chr1 489103 490299 489726 o o EE

chr1 492171 492580 492342 o o EE

chr1 528559 529302 528978 LL

chr1 562064 563166 562603 o o EE

chr1 584378 584705 584532 LL

chr1 591924 592419 592132 LL

chr1 606919 608657 608152 o LE

(with HU)

BrdU incorporation

chr1 633379 633639 633580 LL

chr1 649616 650765 650180 o LE

chr1 662111 662542 662290 LL

chr1 664073 664368 664172 LL

chr1 667696 667909 667756 LL

chr1 678529 679002 678807 LL

chr1 682195 682850 682517 LL

chr1 703204 704263 703452 LL

chr1 707589 708013 707819 LL

chr1 710706 710996 710994 o LE

chr1 714096 715375 714785 o o EE ORI12

chr1 718166 718886 718577 o o EE

chr1 738636 739101 738816 LL

chr1 764620 765925 765248 o LE

chr1 783330 783840 783662 LL

chr1 793579 794733 794248 o o EE

chr1 842512 844796 844262 o o EE

chr1 875654 876657 876173 o o EE

chr1 880162 880705 880365 LL

chr1 892247 893451 893125 LL

chr1 901677 902834 902218 o o EE

chr1 904071 904363 904189 o o EE

chr1 912457 913180 912714 LL

chr1 937802 938363 938099 LL

chr1 956746 957362 957051 LL

chr1 964692 965853 965029 o o EE

chr1 970576 970792 970660 LL

chr1 989805 990437 990185 LL

chr1 994180 995260 994804 LL

chr1 1005294 1006057 1005742 LL

chr1 1015508 1016045 1015679 LL

chr1 1020957 1021701 1021430 LL

chr1 1026493 1027604 1027096 o LE AT1041

chr1 1036256 1036588 1036329 LL

chr1 1046980 1047252 1047021 LL

chr1 1078865 1079792 1079240 o o EE

chr1 1083220 1084272 1083789 o o EE

chr1 1089653 1090690 1090144 o o EE

chr1 1095264 1096416 1095981 o o EE ars1

chr1 1103991 1104571 1104321 LL

chr1 1108334 1108638 1108412 LL

chr1 1111107 1111637 1111343 LL

chr1 1137769 1138521 1138157 LL

chr1 1142144 1142499 1142259 LL

chr1 1147345 1148495 1147984 o LE

chr1 1156486 1157311 1156921 o LE

chr1 1161266 1162076 1161697 LL

chr1 1185443 1186245 1185774 o o EE

chr1 1189952 1191410 1190654 o o EE

chr1 1195557 1196740 1196037 o o EE

chr1 1235390 1235615 1235533 LL

chr1 1254331 1255361 1255033 o o EE

chr1 1274155 1275287 1274569 o o EE

chr1 1276045 1277330 1276573 o o EE

chr1 1282385 1283002 1282775 LL

chr1 1290048 1290421 1290121 LL

chr1 1295179 1295946 1295621 LL

chr1 1314922 1315719 1315357 LL

chr1 1351240 1351808 1351485 LL

chr1 1357356 1357775 1357589 o LE

chr1 1359314 1360134 1359423 o LE

chr1 1375938 1377121 1376275 LL

chr1 1387004 1387804 1387445 o EL

chr1 1398953 1399490 1399141 LL

chr1 1420570 1421668 1420989 o EL

chr1 1443192 1444310 1443760 o o EE

chr1 1449520 1449967 1449744 LL

chr1 1451425 1451890 1451610 LL

chr1 1475787 1477065 1476518 o o EE

chr1 1484964 1485603 1485284 LL

chr1 1488028 1488883 1488468 o EL

chr1 1494680 1495085 1494899 LL

chr1 1498727 1499216 1498979 LL

chr1 1507762 1507938 1507875 o o EE

chr1 1508417 1509787 1509143 o o EE

chr1 1516669 1517134 1516839 LL

chr1 1526630 1527269 1526757 LL

chr1 1542008 1542513 1542245 LL

chr1 1572734 1575227 1573269 o LE

chr1 1595560 1596276 1595938 o LE

chr1 1598633 1599692 1599185 o LE

chr1 1603164 1604101 1603695 o LE

chr1 1615457 1615609 1615587 LL

chr1 1621177 1621547 1621293 LL

chr1 1635344 1635868 1635603 LL

chr1 1643046 1643262 1643151 LL

chr1 1664012 1665829 1664743 o LE

chr1 1666136 1667424 1666701 o LE

chr1 1694765 1695212 1694911 LL

chr1 1701767 1702402 1702147 o EL

chr1 1707417 1708599 1708172 o o EE

chr1 1717517 1718885 1718171 o o EE

chr1 1724880 1725433 1725214 LL

chr1 1733629 1734723 1734170 o o EE

chr1 1745732 1746381 1746037 LL

chr1 1749165 1750030 1749612 LL

chr1 1766726 1767409 1767025 LL

chr1 1777863 1778442 1778161 LL

chr1 1785257 1785938 1785642 LL

chr1 1795600 1796332 1795952 LL

chr1 1816012 1816500 1816302 LL

chr1 1820703 1821013 1820864 LL

chr1 1826945 1827921 1827341 o o EE

chr1 1830132 1830522 1830343 o o EE

chr1 1833384 1834748 1834074 o o EE

chr1 1837031 1838043 1837546 o o EE

chr1 1854714 1854817 1854743 LL

chr1 1865591 1866504 1866016 LL

chr1 1892043 1892471 1892248 o LE

chr1 1893623 1895205 1894143 o LE

chr1 1905403 1906051 1905776 LL

chr1 1921627 1922090 1921861 LL

chr1 1926547 1926836 1926716 LL

chr1 1945990 1946545 1946233 LL

chr1 1951495 1952380 1952156 o LE

chr1 1953278 1956660 1956085 o LE

chr1 1967787 1968428 1968119 LL

chr1 1974191 1975431 1974834 o o EE

chr1 1982107 1983193 1982729 LL

chr1 1991074 1991612 1991333 LL

chr1 2009052 2009277 2009103 LL

chr1 2017679 2018167 2017926 LL

chr1 2024563 2026222 2025343 o LE

chr1 2032992 2033625 2033301 LL

chr1 2041221 2042138 2041691 o LE

chr1 2047006 2047285 2047208 LL

chr1 2064192 2064644 2064363 LL

chr1 2073311 2073876 2073633 LL

chr1 2082452 2083499 2083027 LL

chr1 2084878 2085322 2085065 LL

chr1 2088679 2089279 2088984 LL

chr1 2095518 2096467 2095971 o LE

chr1 2132382 2132612 2132460 LL

chr1 2139044 2140493 2139896 o LE

chr1 2143964 2145010 2144422 o LE

chr1 2157293 2158280 2157603 LL

chr1 2174080 2174745 2174373 LL

chr1 2186138 2186748 2186546 LL

chr1 2193345 2194797 2193873 o o EE

chr1 2208136 2209039 2208621 LL

chr1 2227155 2228718 2227891 o o EE

chr1 2242888 2243917 2243342 o o EE

chr1 2245327 2245578 2245510 o o EE

chr1 2249104 2250055 2249521 o o EE

chr1 2259552 2259719 2259692 LL

chr1 2262488 2264103 2263437 LL

chr1 2272633 2273812 2273131 o o EE ORI18/ORI J

chr1 2279625 2280803 2280182 o o EE

chr1 2303782 2305063 2304510 o LE

chr1 2325563 2326488 2325978 o LE

chr1 2326914 2327619 2327349 o LE

chr1 2335532 2336436 2335953 o LE

chr1 2339126 2340069 2339590 o LE

chr1 2347428 2348111 2347802 LL

chr1 2349808 2350400 2350038 LL

chr1 2356993 2357681 2357234 LL

chr1 2396943 2397205 2397023 o LE

chr1 2397837 2399176 2398414 o LE

chr1 2405091 2406601 2405586 o LE

chr1 2414269 2416837 2415255 LL

chr1 2418188 2418529 2418352 LL

chr1 2424261 2425468 2424934 o LE

chr1 2438064 2439259 2438647 o o EE rip1

chr1 2441386 2442816 2442319 o o EE

chr1 2451177 2452157 2451687 o o EE

chr1 2456727 2457499 2457202 LL

chr1 2472204 2472675 2472430 LL

chr1 2473521 2474171 2473893 LL

chr1 2477259 2477411 2477351 LL

chr1 2488904 2490043 2489573 o o EE

chr1 2498111 2498380 2498209 LL

chr1 2502121 2502941 2502669 LL

chr1 2520481 2521407 2520922 o LE

chr1 2524563 2525877 2525157 o LE

chr1 2527333 2527961 2527654 o LE

chr1 2537833 2537979 2537960 LL

chr1 2556292 2556504 2556430 LL

chr1 2561683 2562244 2562041 LL

chr1 2577705 2578723 2578230 o o EE

chr1 2583006 2584726 2583407 o LE

chr1 2597605 2598071 2597785 LL

chr1 2600142 2601369 2600680 o o EE

chr1 2613185 2613283 2613222 LL

chr1 2614402 2615096 2614655 LL

chr1 2617424 2618297 2617869 o EL

chr1 2637100 2637815 2637393 LL

chr1 2642262 2643470 2642886 o LE

chr1 2662408 2663730 2663138 o LE

chr1 2667403 2667947 2667660 o LE

chr1 2675958 2676626 2676431 LL

chr1 2683119 2683405 2683263 LL

chr1 2684776 2686268 2685193 LL

chr1 2689104 2689697 2689421 LL

chr1 2691186 2691296 2691196 LL

chr1 2718860 2720263 2719671 o o EE

chr1 2748037 2748962 2748421 o EL

chr1 2750733 2751311 2751077 o EL

chr1 2753666 2754634 2754324 LL

chr1 2760740 2762026 2761461 o o EE

chr1 2774822 2774966 2774886 LL

chr1 2785755 2787137 2786253 o EL

chr1 2802114 2803906 2803254 o o EE

chr1 2813352 2814087 2813795 o EL

chr1 2815478 2815875 2815603 LL

chr1 2829675 2829941 2829730 LL

chr1 2835793 2836282 2835996 LL

chr1 2844689 2845442 2845015 LL

chr1 2861683 2862480 2862185 o o EE

chr1 2874270 2875551 2875135 o LE

chr1 2882395 2883207 2882734 o o EE

chr1 2910539 2911340 2910833 o EL

chr1 2912311 2913973 2912825 o o EE

chr1 2937194 2938109 2937701 o o EE

chr1 2946450 2947001 2946764 LL

chr1 2959727 2961116 2960596 o o EE

chr1 2976496 2978303 2977279 o o EE

chr1 2978919 2979992 2979586 o o EE

chr1 2982266 2984208 2982840 o o EE

chr1 3009371 3010313 3009808 o o EE

chr1 3021561 3022819 3022022 o o EE

chr1 3032605 3033063 3032933 LL

chr1 3051743 3053214 3052853 o EL

chr1 3059235 3060418 3059741 o o EE ORI76

chr1 3126860 3127602 3127241 o o EE

chr1 3143009 3145056 3143714 o o EE

chr1 3157796 3158886 3158282 o LE

chr1 3164501 3165238 3164773 LL

chr1 3177330 3177531 3177432 LL

chr1 3183301 3184980 3184034 o o EE

chr1 3206846 3207470 3207163 o EL

chr1 3208472 3209121 3208708 o EL

chr1 3226046 3226776 3226469 LL

chr1 3237363 3237644 3237496 LL

chr1 3238872 3239003 3238979 LL

chr1 3245440 3246397 3245862 o o EE

chr1 3269387 3270278 3269774 o o EE

chr1 3279774 3281051 3280669 LL

chr1 3285520 3286297 3285865 LL

chr1 3299448 3301038 3300087 o o EE

chr1 3320151 3321487 3320789 o o EE pARS767

chr1 3324846 3325036 3324925 o EL

chr1 3375486 3376188 3375919 LL

chr1 3404161 3405574 3404908 o o EE

chr1 3409911 3411075 3410433 o o EE

chr1 3429190 3429568 3429286 LL

chr1 3442509 3444001 3443349 o o EE

chr1 3462052 3463008 3462514 o EL

chr1 3497450 3498490 3498042 o o EE ORIc27

chr1 3508109 3508536 3508407 LL

chr1 3519609 3520216 3519923 o EL

chr1 3524275 3525390 3524802 o EL

chr1 3529847 3530200 3529984 LL

chr1 3540614 3541204 3541001 o EL

chr1 3547863 3548941 3548391 o o EE

chr1 3558347 3560201 3558896 o EL

chr1 3569211 3569814 3569516 o EL

chr1 3576043 3577340 3576529 o o EE

chr1 3578606 3579396 3578941 o o EE

chr1 3592058 3592853 3592398 o EL

chr1 3601099 3601528 3601409 LL

chr1 3610852 3611945 3611482 o EL

chr1 3634226 3635333 3634907 o o EE

chr1 3671555 3671909 3671734 LL

chr1 3692568 3693029 3692851 o EL

chr1 3699834 3701163 3700292 o o EE

chr1 3728368 3729200 3728832 o EL

chr1 3735739 3736613 3736224 o o EE

chr1 3743102 3743885 3743528 o EL

chr1 3745418 3745769 3745554 o EL

chr1 3751603 3752501 3751992 o o EE

chr1 3769067 3769567 3769409 LL

chr1 3772832 3773181 3772888 LL

chr1 3790499 3790876 3790780 o EL

chr1 3801868 3802097 3802059 LL

chr1 3808747 3808874 3808837 LL

chr1 3811570 3812513 3812107 o EL

chr1 3829891 3830485 3830256 LL

chr1 3836969 3837313 3837137 o EL

chr1 3839740 3841105 3840427 o o EE

chr1 3851670 3852873 3852254 o EL

chr1 3863441 3863833 3863742 LL

chr1 3877423 3878731 3878135 o o EE

chr1 3881244 3882548 3882076 o o EE

chr1 3897518 3898200 3897853 o EL

chr1 3908757 3909242 3908983 LL

chr1 3952168 3953332 3952764 o o EE

chr1 3994858 3995560 3995180 o o EE

chr1 4018459 4019750 4019205 o o EE

chr1 4059241 4059542 4059542 LL

chr1 4064900 4065677 4065209 o EL

chr1 4070839 4072157 4071359 o o EE

chr1 4087474 4088653 4088272 o o EE

chr1 4118993 4119614 4119326 LL

chr1 4121800 4122017 4121895 LL

chr1 4133659 4133904 4133783 o o EE

chr1 4136518 4137478 4136980 o o EE

chr1 4139917 4140357 4140015 o o EE

chr1 4140704 4141293 4140959 o o EE

chr1 4153172 4154340 4153699 o o EE

chr1 4162031 4162467 4162276 LL

chr1 4179176 4179932 4179548 o LE

chr1 4183572 4185424 4184776 o o EE

chr1 4196306 4197462 4196927 o o EE

chr1 4205661 4205915 4205809 LL

chr1 4223247 4223524 4223423 LL

chr1 4230227 4230599 4230431 o EL

chr1 4231681 4231778 4231737 o EL

chr1 4232419 4232972 4232610 o o EE

chr1 4237625 4239331 4238618 o o EE

chr1 4241059 4241963 4241557 o o EE

chr1 4253403 4254609 4254071 o o EE

chr1 4264730 4265136 4265054 LL

chr1 4266216 4266689 4266525 LL

chr1 4273827 4275120 4274459 o o EE

chr1 4286152 4286569 4286330 LL

chr1 4292580 4293081 4292824 LL

chr1 4297964 4299179 4298596 o EL

chr1 4325289 4326471 4325725 o o EE

chr1 4358020 4358335 4358117 LL

chr1 4364844 4365913 4365396 o LE

chr1 4386664 4387010 4386907 LL

chr1 4414251 4415386 4414890 o o EE

chr1 4428952 4429072 4429023 LL

chr1 4435262 4435984 4435564 o o EE

chr1 4438054 4439431 4438623 o o EE

chr1 4449816 4451210 4450652 o o EE

chr1 4457159 4459014 4458709 o LE

chr1 4467279 4467914 4467636 LL

chr1 4483053 4484244 4483685 o o EE

chr1 4485894 4486209 4486056 o o EE

chr1 4491631 4491740 4491653 LL

chr1 4515814 4515976 4515835 LL

chr1 4518734 4519279 4518979 LL

chr1 4532828 4533601 4533226 o o EE

chr1 4540801 4541433 4541041 LL

chr1 4566036 4566435 4566187 LL

chr1 4577295 4578187 4577750 LL

chr1 4603455 4604985 4604195 o LE

chr1 4613275 4613724 4613512 LL

chr1 4618325 4618883 4618558 LL

chr1 4645248 4645451 4645309 LL

chr1 4647771 4648113 4648022 LL

chr1 4651209 4652938 4652373 o LE

chr1 4663817 4664492 4664183 LL

chr1 4673765 4674733 4674137 o LE

chr1 4701406 4702229 4701766 o LE

chr1 4705636 4707001 4706394 o LE

chr1 4715211 4715619 4715383 LL

chr1 4738754 4739919 4739397 o o EE

chr1 4771532 4771911 4771682 LL

chr1 4778079 4779050 4778491 o o EE

chr1 4788662 4789219 4788950 LL

chr1 4796343 4797317 4796771 LL

chr1 4798840 4799407 4799075 LL

chr1 4802331 4803355 4802987 o o EE

chr1 4811775 4812087 4811932 LL

chr1 4838634 4839227 4838949 LL

chr1 4843750 4844762 4844305 o EL

chr1 4846107 4846786 4846496 o EL

chr1 4852036 4853188 4852411 o o EE

chr1 4872247 4874055 4872999 o EL

chr1 4880986 4882283 4881541 o o EE

chr1 4895050 4895596 4895379 LL

chr1 4900042 4900369 4900201 LL

chr1 4915504 4917154 4916459 LL

chr1 4923247 4924398 4923743 o o EE

chr1 4933714 4934832 4934251 o EL

chr1 4962217 4963913 4963412 o o EE

chr1 4977411 4978370 4977956 o EL

chr1 4984023 4984161 4984107 LL

chr1 5001962 5002488 5002157 LL

chr1 5023850 5024860 5024408 o o EE

chr1 5045013 5045876 5045474 o o EE

chr1 5077538 5078218 5077805 LL

chr1 5095844 5097134 5096331 o o EE

chr1 5122268 5122874 5122525 LL

chr1 5138905 5140491 5139918 o o EE

chr1 5155010 5156544 5156135 o o EE

chr1 5172716 5173503 5173091 o o EE

chr1 5176555 5178052 5177489 o o EE

chr1 5185970 5186977 5186690 o LE

chr1 5188827 5189657 5189317 o LE

chr1 5232899 5234165 5233536 o o EE

chr1 5252690 5253584 5253253 LL

chr1 5269285 5272582 5269787 o LE

chr1 5293623 5295226 5294784 LL

chr1 5297667 5298302 5297852 LL

chr1 5300065 5300602 5300224 LL

chr1 5317011 5317697 5317224 o LE

chr1 5319523 5319779 5319668 o LE

chr1 5321153 5322686 5321781 o LE

chr1 5343377 5343747 5343529 LL

chr1 5345698 5346157 5345914 LL

chr1 5351815 5352234 5351963 LL

chr1 5354176 5354784 5354515 LL

chr1 5367258 5367369 5367306 LL

chr1 5392324 5393450 5392888 o o EE

chr1 5413224 5414255 5413793 LL

chr1 5426176 5427103 5426586 LL

chr1 5434662 5435717 5435163 o LE

chr1 5443749 5444226 5443960 o LE

chr1 5447508 5448784 5448225 o LE

chr1 5451523 5452028 5451671 o LE

chr1 5453974 5454104 5454015 LL

chr1 5468555 5470336 5469917 o LE

chr1 5475500 5476316 5475776 o LE

chr1 5481618 5482878 5482044 o LE

chr1 5486302 5486767 5486553 LL

chr1 5488924 5489011 5488988 LL

chr1 5496829 5498341 5497770 o LE

chr1 5500714 5504367 5501582 o LE

chr1 5509044 5512172 5510864 LL

chr1 5514078 5516124 5515243 o LE

chr1 5519891 5521799 5520943 o LE

chr1 5523437 5524923 5524470 o LE

chr1 5525834 5527019 5526365 o LE

chr1 5528834 5534539 5529770 o LE

chr1 5536152 5538005 5537129 o LE

chr1 5539575 5540056 5539904 o LE

chr1 5543138 5545674 5544446 o LE

chr1 5546410 5548003 5547196 o LE

chr1 5550246 5552675 5551050 o LE

chr1 5554049 5555422 5554721 o LE

chr1 5557318 5559145 5558341 o LE

chr2 29517 33179 31295 o LE

chr2 36810 38766 37640 o LE

chr2 41831 45203 44067 o LE

chr2 46237 47505 46596 o LE

chr2 51607 54229 52762 o LE

chr2 59932 62385 61736 o LE

chr2 65916 69038 66644 o LE

chr2 71099 71700 71520 o LE

chr2 73498 75169 74297 o LE

chr2 77685 79125 78610 o LE

chr2 82939 83634 83192 o LE

chr2 85220 88230 86963 o LE

chr2 88849 91259 89901 o LE

chr2 102648 103654 102988 o LE

chr2 107465 107552 107511 o LE

chr2 108894 111084 110529 o LE

chr2 114307 118234 117411 o LE

chr2 121815 122187 121984 LL

chr2 129941 132159 131152 o LE

chr2 140477 141593 140970 o LE

chr2 150638 151842 151007 o o EE

chr2 159786 160369 160041 LL

chr2 193744 194321 194020 LL

chr2 200746 201733 201272 o LE

chr2 203111 204136 203655 o LE

chr2 218470 219074 218833 LL

chr2 228193 228801 228377 LL

chr2 257780 259009 258320 o o EE

chr2 277021 278211 277504 o o EE

chr2 281100 281827 281481 o o EE

chr2 287927 288916 288451 o EL

chr2 306860 308611 308112 LL

chr2 309503 310465 309631 LL

chr2 314403 315372 315076 o o EE

chr2 323094 324173 323606 o o EE

chr2 325013 327232 325897 o o EE ori2-326

chr2 331349 333055 332160 o o EE

chr2 340009 340712 340363 o EL

chr2 355428 355997 355794 o EL

chr2 359773 360437 360062 LL

chr2 389702 391123 390659 LL

chr2 407897 409484 408936 o o EE

chr2 431907 432048 431968 LL

chr2 447353 449118 447793 o LE

chr2 452741 454246 453674 o LE

chr2 459967 460814 460386 LL

chr2 483396 483891 483591 LL

chr2 487301 487408 487389 LL

chr2 489503 489901 489718 LL

chr2 509239 509625 509419 o EL

chr2 512482 513700 513295 o o EE

chr2 515882 516362 516208 o o EE

chr2 519480 520737 519942 o o EE

chr2 521776 522498 522177 o o EE

chr2 528509 529029 528722 LL

chr2 536597 536738 536614 LL

chr2 560401 560923 560632 LL

chr2 569253 570280 569751 o o EE

chr2 580066 580376 580228 LL

chr2 591271 592035 591650 o EL

chr2 592669 592969 592854 o EL

chr2 600461 600675 600566 o o EE

chr2 602564 603678 603076 o o EE AT2026

chr2 605304 606056 605549 o o EE

chr2 611731 612492 612148 o EL

chr2 625187 625849 625553 LL

chr2 633023 633667 633230 o EL

chr2 636211 637415 636737 o o EE

chr2 649118 649952 649468 o EL

chr2 658107 658372 658194 LL

chr2 668897 669563 669312 o o EE

chr2 673276 674443 673779 o o EE

chr2 683156 684126 683683 o o EE

chr2 685854 686660 686282 o o EE

chr2 716425 717177 716734 o EL

chr2 720396 720983 720737 o o EE

chr2 722920 723685 723309 o o EE

chr2 744675 746174 745107 o o EE

chr2 754007 754416 754221 LL

chr2 757930 758281 758047 LL

chr2 783780 784559 784215 LL

chr2 803025 804283 803523 o EL

chr2 823063 824215 823554 o o EE

chr2 832261 832804 832553 LL

chr2 836369 836875 836742 LL

chr2 842356 843254 842723 o o EE

chr2 846223 848176 847425 o o EE

chr2 883584 883984 883826 LL

chr2 888876 891984 891664 o LE

chr2 914442 915158 914779 o EL

chr2 937917 938824 938431 LL

chr2 948016 949125 948536 o LE

chr2 949556 950124 949889 o LE

chr2 954278 954449 954379 o LE

chr2 956569 957703 957123 o o EE

chr2 963324 964412 963838 o LE

chr2 970042 970544 970291 LL

chr2 1006693 1007746 1007080 o LE

chr2 1019164 1019680 1019422 LL

chr2 1021637 1022172 1021888 LL

chr2 1034600 1035340 1034868 LL

chr2 1053673 1053905 1053888 o EL

chr2 1054763 1055364 1054981 o EL

chr2 1057724 1058511 1058025 o EL

chr2 1063219 1063591 1063409 LL

chr2 1075925 1076165 1076119 o LE

chr2 1079379 1080184 1079736 o LE

chr2 1087333 1087467 1087441 LL

chr2 1104753 1106009 1105456 o o EE

chr2 1110409 1111253 1110818 o EL

chr2 1141075 1142090 1141635 o o EE

chr2 1148036 1148628 1148252 o o EE

chr2 1149631 1150515 1149994 o o EE

chr2 1155554 1156791 1156356 o o EE

chr2 1170762 1171371 1170999 LL

chr2 1176124 1176397 1176335 LL

chr2 1216091 1216188 1216091 LL

chr2 1231995 1232735 1232347 LL

chr2 1239454 1239932 1239657 o o EE

chr2 1241044 1241485 1241232 o o EE

chr2 1243686 1244876 1244230 o o EE

chr2 1254100 1255149 1254651 o o EE AT2041

chr2 1264363 1265356 1264932 o o EE

chr2 1265887 1266640 1266202 o o EE

chr2 1277133 1278132 1277627 o o EE ORI c7

chr2 1282008 1282871 1282381 o o EE

chr2 1285648 1286220 1285880 o EL

chr2 1306189 1306984 1306708 o EL

chr2 1311843 1313048 1312524 o o EE

chr2 1323286 1323972 1323594 LL

chr2 1349661 1350749 1350303 o EL

chr2 1388778 1389803 1389321 o o EE

chr2 1401979 1403118 1402276 LL

chr2 1406122 1406566 1406394 LL

chr2 1427491 1428604 1428041 o EL

chr2 1442697 1444091 1443438 o o EE

chr2 1456288 1457213 1456783 o o EE

chr2 1461193 1461991 1461590 o EL

chr2 1467231 1467756 1467494 LL

chr2 1477444 1477805 1477615 LL

chr2 1499902 1500387 1500144 LL

chr2 1527001 1527570 1527342 o EL

chr2 1531413 1531963 1531561 o EL

chr2 1536380 1536725 1536633 LL

chr2 1544814 1545977 1545445 o o EE ars2004

chr2 1557133 1558073 1557544 o EL ars2003

chr2 1562190 1562359 1562269 LL

chr2 1588721 1589647 1589122 o o EE ars2002

chr2 1596746 1597615 1597189 o o EE

chr2 1601689 1602097 1601997 o EL

chr2 1603145 1603693 1603389 o EL

chr2 1620819 1627602 1622844 o EL

chr2 1643014 1643847 1643342 o o EE

chr2 1646960 1647384 1647159 o EL

chr2 1654551 1655456 1654938 o EL

chr2 1659726 1660106 1659872 o EL

chr2 1662750 1663383 1663064 o EL

chr2 1699339 1700146 1699791 o EL

chr2 1703560 1704534 1704030 o EL

chr2 1706053 1706866 1706465 o EL

chr2 1716569 1717964 1717396 o o EE

chr2 1748110 1750635 1749641 o o EE

chr2 1755401 1755982 1755632 LL

chr2 1765146 1766046 1765668 o EL

chr2 1777818 1779469 1778671 o o EE

chr2 1803781 1805660 1804998 o o EE

chr2 1867285 1868927 1868248 o LE

chr2 1877696 1878596 1878242 LL

chr2 1892404 1893290 1892948 o EL

chr2 1914424 1915346 1914936 o EL

chr2 1928171 1928982 1928486 o EL

chr2 1940999 1942313 1941654 o o EE

chr2 1952255 1953496 1952895 o o EE

chr2 1962438 1964651 1964077 o o EE

chr2 2007415 2007695 2007593 LL

chr2 2021993 2023614 2022531 o o EE

chr2 2031157 2032156 2031642 o o EE

chr2 2051266 2052402 2051881 o o EE

chr2 2069305 2070367 2069758 o o EE

chr2 2075058 2075326 2075198 LL

chr2 2091863 2092540 2092221 LL

chr2 2103988 2105136 2104513 o LE

chr2 2117223 2118313 2117696 o LE pARS756/ORI75

chr2 2120032 2120227 2120142 o LE

chr2 2125680 2126124 2125888 LL

chr2 2128437 2129234 2128949 o o EE

chr2 2131249 2132462 2131782 o o EE

chr2 2134699 2134955 2134846 o o EE

chr2 2137016 2137856 2137340 o o EE

chr2 2154477 2155219 2154826 LL

chr2 2162938 2163448 2163150 LL

chr2 2176522 2177955 2177573 LL

chr2 2185100 2187070 2185589 o o EE AT2072

chr2 2204172 2205375 2204799 LL

chr2 2209498 2209966 2209704 LL

chr2 2213440 2214356 2213921 LL

chr2 2224825 2225120 2224950 o EL

chr2 2229140 2230186 2229452 LL

chr2 2237538 2238360 2237888 LL

chr2 2245559 2246663 2246190 o EL

chr2 2254308 2255078 2254711 LL

chr2 2261471 2261981 2261790 LL

chr2 2264858 2265960 2265474 o LE

chr2 2273275 2274289 2273811 LL

chr2 2282249 2282567 2282408 LL

chr2 2294447 2295065 2294882 LL

chr2 2318426 2319549 2318991 o o EE

chr2 2337536 2339983 2339233 o LE

chr2 2347164 2348248 2347793 LL

chr2 2365922 2366869 2366398 LL

chr2 2384762 2385068 2384878 LL

chr2 2410172 2411382 2410768 o LE

chr2 2433801 2434525 2434209 LL

chr2 2442805 2444262 2443650 o o EE

chr2 2451058 2452081 2451688 LL

chr2 2481825 2482268 2482021 LL

chr2 2484759 2485461 2485158 LL

chr2 2497625 2499203 2498556 o LE

chr2 2522854 2523981 2523312 o o EE

chr2 2527296 2527703 2527445 LL

chr2 2535828 2536145 2535990 LL

chr2 2552464 2553334 2552998 o o EE

chr2 2565301 2565994 2565659 LL

chr2 2580368 2581663 2581105 o LE AT2080

chr2 2593044 2594004 2593532 o LE

chr2 2615317 2616029 2615647 LL

chr2 2626735 2627130 2626990 LL

chr2 2632067 2632837 2632457 LL

chr2 2640272 2641383 2640798 o LE

chr2 2647096 2648764 2647465 o LE

chr2 2659742 2660498 2660092 LL

chr2 2662158 2662421 2662334 LL

chr2 2670370 2671887 2670984 o LE

chr2 2693667 2694225 2694034 LL

chr2 2700180 2703214 2701594 o o EE

chr2 2722695 2722845 2722732 LL

chr2 2728712 2729124 2729011 LL

chr2 2732172 2733277 2732608 o o EE

chr2 2737950 2739276 2738485 o o EE

chr2 2749912 2750278 2750254 LL

chr2 2767801 2768401 2768129 LL

chr2 2776859 2777572 2777172 LL

chr2 2785734 2786870 2786209 o o EE

chr2 2790137 2791290 2790742 o o EE tug1

chr2 2798289 2799496 2799022 o o EE rum1

chr2 2804546 2805062 2804732 LL

chr2 2827215 2829293 2828750 o LE pARS745

chr2 2847510 2848031 2847787 LL

chr2 2873434 2873848 2873649 LL

chr2 2884944 2885300 2885096 LL

chr2 2900229 2901225 2900728 o o EE pARS772

chr2 2909569 2910085 2909864 LL

chr2 2911570 2912257 2911897 LL

chr2 2931233 2931907 2931588 LL

chr2 2932863 2933028 2932993 LL

chr2 2938590 2939791 2939107 o o EE

chr2 2947010 2947559 2947353 LL

chr2 2966990 2967379 2967188 LL

chr2 2985986 2987188 2986660 o o EE

chr2 3004106 3004565 3004266 LL

chr2 3007555 3008609 3008190 o LE

chr2 3022196 3023153 3022932 LL

chr2 3037295 3037577 3037414 LL

chr2 3040762 3041349 3041126 LL

chr2 3051514 3052694 3052223 o o EE

chr2 3058725 3059533 3059070 LL

chr2 3065102 3065459 3065172 LL

chr2 3068802 3070423 3069490 LL

chr2 3096893 3098272 3097445 o o EE

chr2 3126678 3127195 3126879 LL

chr2 3136590 3138346 3137129 LL

chr2 3149729 3150381 3150038 LL

chr2 3152476 3153508 3153120 o LE

chr2 3161429 3163021 3161916 o LE

chr2 3168429 3168927 3168699 LL

chr2 3171621 3172192 3171911 o LE

chr2 3175560 3176538 3176055 o o EE

chr2 3199190 3200241 3199707 o LE

chr2 3209325 3209802 3209615 LL

chr2 3210799 3211291 3211059 LL

chr2 3213912 3214106 3214016 LL

chr2 3235614 3236702 3236121 o o EE

chr2 3237347 3238300 3237886 o o EE

chr2 3251595 3252236 3251902 LL

chr2 3253638 3253887 3253638 LL

chr2 3286380 3287635 3287018 o o EE

chr2 3302302 3303283 3302848 LL

chr2 3323808 3324060 3323922 LL

chr2 3332469 3333833 3333141 o LE

chr2 3336976 3338460 3337485 o LE

chr2 3347110 3347602 3347283 LL

chr2 3357123 3357769 3357470 o LE

chr2 3360345 3361547 3360874 o o EE

chr2 3378647 3380700 3379201 o LE pARS727

chr2 3396409 3397092 3396779 LL

chr2 3421774 3422854 3422407 o o EE

chr2 3448298 3448934 3448700 LL

chr2 3456914 3457255 3457014 LL

chr2 3466092 3467141 3466673 o EL

chr2 3471937 3472374 3472202 LL

chr2 3487499 3489229 3488358 o LE

chr2 3490721 3491789 3491144 o LE

chr2 3502058 3502689 3502356 LL

chr2 3509804 3510528 3510237 o LE

chr2 3512521 3513675 3513238 o LE

chr2 3538128 3538623 3538390 LL

chr2 3555811 3556964 3556378 o LE

chr2 3561481 3561694 3561587 LL

chr2 3573849 3574343 3574050 LL

chr2 3584583 3585474 3585067 LL

chr2 3590556 3591201 3590941 LL

chr2 3596788 3597081 3596841 LL

chr2 3604944 3605882 3605501 o LE

chr2 3615475 3616613 3616030 LL

chr2 3634323 3635466 3635032 o o EE

chr2 3640637 3640883 3640843 LL

chr2 3651515 3651767 3651595 LL

chr2 3659244 3660023 3659625 o o EE

chr2 3665312 3665749 3665606 LL

chr2 3669980 3671298 3670782 LL

chr2 3680852 3681774 3681239 o LE

chr2 3691986 3692253 3692210 LL

chr2 3697453 3698760 3698029 LL

chr2 3702941 3703459 3703203 LL

chr2 3706302 3706603 3706382 LL

chr2 3714283 3715134 3714736 LL

chr2 3719826 3721182 3720418 o LE

chr2 3723364 3723553 3723432 o LE

chr2 3732318 3732670 3732498 LL

chr2 3733777 3734409 3733934 LL

chr2 3751432 3752327 3751903 LL

chr2 3753717 3754188 3754006 LL

chr2 3761845 3762831 3762297 o o EE

chr2 3777002 3777719 3777399 LL

chr2 3784648 3785243 3784940 LL

chr2 3798718 3799511 3798940 o o EE

chr2 3801700 3802221 3801837 o EL

chr2 3804579 3805787 3805096 o EL

chr2 3814471 3815881 3814994 o o EE

chr2 3816708 3818064 3817702 o o EE

chr2 3821914 3822142 3822067 LL

chr2 3826170 3827108 3826611 LL

chr2 3838288 3839668 3838940 o o EE

chr2 3868595 3869729 3869252 LL

chr2 3897689 3898167 3897870 LL

chr2 3915655 3916616 3916089 o o EE

chr2 3925719 3927251 3926563 o LE

chr2 3937757 3938851 3938161 o LE

chr2 3944809 3945956 3945425 o LE

chr2 3949070 3949230 3949213 LL

chr2 3953759 3954472 3954152 LL

chr2 3959598 3959882 3959690 LL

chr2 3970474 3970771 3970625 LL

chr2 3975346 3976250 3975791 LL

chr2 3987206 3987685 3987431 LL

chr2 3989361 3990370 3989778 LL

chr2 3999408 4000265 3999846 LL

chr2 4006265 4006665 4006479 LL

chr2 4010549 4011006 4010888 LL

chr2 4018858 4019908 4019415 o o EE

chr2 4029133 4030492 4029664 o LE

chr2 4031487 4033572 4033028 o LE

chr2 4047538 4048674 4048191 o LE

chr2 4066007 4066333 4066228 LL

chr2 4070659 4071017 4070866 LL

chr2 4093880 4094092 4094024 LL

chr2 4096198 4096724 4096432 LL

chr2 4106697 4107839 4107305 o LE

chr2 4128445 4130584 4129073 o LE

chr2 4139114 4140303 4139742 o o EE

chr2 4144353 4145292 4144757 LL

chr2 4146580 4147033 4146847 LL

chr2 4151098 4151630 4151280 LL

chr2 4171875 4172502 4172196 LL

chr2 4178013 4178305 4178199 LL

chr2 4194414 4195006 4194645 LL

chr2 4201900 4203333 4202725 o o EE

chr2 4217226 4217981 4217612 LL

chr2 4224968 4226590 4225805 o LE

chr2 4235831 4237067 4236332 o LE

chr2 4242264 4243165 4242771 LL

chr2 4251583 4252535 4252117 o LE

chr2 4255312 4255667 4255455 LL

chr2 4261343 4261753 4261569 LL

chr2 4268315 4268891 4268570 LL

chr2 4291910 4293095 4292517 o LE

chr2 4302508 4303195 4302897 LL

chr2 4315612 4316082 4315911 LL

chr2 4321465 4321993 4321736 LL

chr2 4333283 4334050 4333621 LL

chr2 4343304 4344510 4343884 o LE

chr2 4349416 4349698 4349608 LL

chr2 4359935 4361117 4360652 o LE

chr2 4374810 4375836 4375356 o LE

chr2 4379727 4380642 4380168 LL

chr2 4393061 4393401 4393239 LL

chr2 4403127 4404099 4403520 LL

chr2 4409985 4410757 4410381 LL

chr2 4411392 4414032 4412346 LL

chr2 4419429 4420850 4420108 o LE

chr2 4425580 4426096 4425788 LL

chr2 4429334 4430045 4429583 LL

chr2 4438206 4440875 4440391 o LE

chr2 4449820 4452514 4451867 o LE ori2-4451

chr2 4453268 4456796 4454433 o LE

chr2 4461904 4462557 4462203 LL

chr2 4463662 4464893 4464212 o LE

chr2 4467533 4469598 4468664 o LE

chr2 4471146 4474393 4473666 o LE

chr2 4474917 4475863 4475374 o LE

chr2 4476236 4478692 4477096 o LE

chr2 4481925 4482424 4482170 LL

chr2 4490300 4492117 4491600 o LE

chr2 4532521 4533925 4532828 o LE

chr2 4534956 4536374 4535712 LL

chr2 4536940 4537345 4537322 LL

chr2 4538024 4538339 4538034 LL

chr3 32183 32413 32309 o o EE

chr3 34519 37080 35605 o o EE

chr3 41840 42244 42001 o EL

chr3 49849 50551 50156 LL

chr3 54169 54586 54421 o EL

chr3 61051 62082 61501 o EL

chr3 75787 76776 76325 o o EE

chr3 90798 91092 90932 LL

chr3 107886 108372 108100 LL

chr3 111136 111299 111157 o EL

chr3 115272 117178 116069 o o EE

chr3 119907 120669 120280 o o EE

chr3 122765 124404 123506 o o EE ars3002/3004

chr3 145707 146071 145879 LL

chr3 188745 189466 189087 o EL

chr3 190512 190661 190572 o EL

chr3 201489 202020 201767 o EL

chr3 203779 204465 204134 o EL

chr3 218344 218828 218584 LL

chr3 231442 232676 231988 o o EE

chr3 239268 239567 239403 o EL

chr3 247660 248138 247913 o EL

chr3 252755 254224 253378 o o EE

chr3 258035 258465 258241 o EL

chr3 258939 259480 259163 o EL

chr3 274780 275180 274969 LL

chr3 278238 278463 278356 LL

chr3 286259 287346 286784 o o EE

chr3 299417 300063 299849 o EL

chr3 305062 305466 305164 o EL

chr3 308408 309329 308845 o EL

chr3 313082 313273 313183 o EL

chr3 330663 331355 331042 o EL ori3-331

chr3 332786 333866 333229 o EL ori3-333

chr3 339862 340252 340123 LL

chr3 368887 370807 369327 o o EE

chr3 397615 398908 398324 o o EE

chr3 429643 430025 429821 LL

chr3 454717 455298 454982 o EL ori3-455

chr3 472577 473364 472985 o o EE

chr3 483037 483329 483141 LL

chr3 486045 486597 486344 LL

chr3 504949 506191 505504 o o EE

chr3 518237 519413 518942 o o EE

chr3 522801 523309 522987 o o EE

chr3 527043 527606 527258 o EL

chr3 531561 531898 531717 o EL

chr3 552452 552647 552512 LL

chr3 558476 559087 558751 o EL

chr3 565023 566106 565470 o o EE

chr3 568032 568755 568346 o o EE

chr3 574377 575525 574938 o o EE

chr3 582685 582943 582863 LL

chr3 604640 606161 605234 o o EE

chr3 630925 632206 631483 o EL

chr3 642477 643726 643192 o o EE

chr3 665829 666911 666334 o o EE

chr3 690349 690490 690464 LL

chr3 708056 709017 708592 o EL

chr3 719312 720528 719865 o o EE

chr3 728332 728768 728568 o EL

chr3 751639 752347 751965 o EL

chr3 763504 764660 763895 o o EE

chr3 765361 766381 765775 o o EE

chr3 791093 791591 791324 o EL

chr3 816471 817318 816901 o EL

chr3 820476 821410 820960 o o EE

chr3 827459 828169 827786 o EL

chr3 831036 831510 831337 o EL

chr3 836831 837563 837254 LL

chr3 844159 844434 844284 o EL

chr3 847330 848376 847497 o EL

chr3 853222 854377 853851 o o EE

chr3 882724 883226 882960 LL

chr3 899553 900153 899778 LL

chr3 906226 906666 906477 o EL

chr3 907215 907627 907433 o EL

chr3 935154 937724 936601 o o EE

chr3 967247 967387 967311 o o EE

chr3 967793 968361 968150 o o EE

chr3 971223 972633 972004 o o EE

chr3 985321 986462 985897 o o EE

chr3 1002408 1002873 1002707 LL

chr3 1011166 1011695 1011437 LL

chr3 1022267 1022612 1022417 LL

chr3 1038834 1040047 1039590 o o EE

chr3 1067095 1067845 1067459 o o EE

chr3 1068233 1069891 1069531 o o EE

chr3 1097040 1098951 1098620 LL

chr3 1140570 1142740 1141024 o o EE

chr3 1168195 1168860 1168590 o EL

chr3 1193010 1194374 1193841 o o EE

chr3 1202008 1202362 1202151 LL

chr3 1216632 1217068 1216853 LL

chr3 1252335 1253448 1252848 o o EE

chr3 1282181 1283112 1282635 o EL

chr3 1296107 1296816 1296499 LL

chr3 1322305 1323693 1323149 o o EE

chr3 1341518 1343126 1342614 o o EE

chr3 1361029 1361628 1361305 LL

chr3 1370320 1371295 1370712 o o EE

chr3 1372306 1373097 1372714 o o EE

chr3 1391871 1392348 1392082 o o EE

chr3 1394860 1396457 1395361 o o EE

chr3 1401499 1401956 1401813 o EL

chr3 1403006 1403367 1403114 o EL

chr3 1407291 1407641 1407493 o o EE

chr3 1409868 1410755 1410347 o o EE AT3043

chr3 1416322 1417552 1416886 o o EE AT3044

chr3 1425775 1426559 1426243 LL

chr3 1447669 1449136 1448123 o o EE

chr3 1466895 1467477 1467160 LL

chr3 1474546 1474901 1474650 LL

chr3 1504559 1505100 1504776 o EL

chr3 1510212 1511184 1510703 o o EE

chr3 1523508 1523923 1523795 LL

chr3 1530610 1531674 1531015 o o EE

chr3 1554767 1556125 1555772 o EL

chr3 1575214 1576408 1575871 o o EE

chr3 1593805 1595076 1594521 o o EE

chr3 1607971 1609273 1608641 o o EE

chr3 1665056 1665359 1665247 LL

chr3 1671908 1672717 1672335 o EL

chr3 1679292 1680166 1679722 o o EE

chr3 1683597 1684750 1684026 o o EE

chr3 1688861 1689700 1689376 o o EE

chr3 1718268 1719256 1718763 o o EE

chr3 1720736 1724152 1722539 o o EE AT3053

chr3 1727206 1728308 1727748 o o EE

chr3 1745348 1745990 1745737 o EL

chr3 1753082 1754296 1753768 o o EE

chr3 1783090 1783515 1783326 LL

chr3 1794216 1794653 1794425 LL

chr3 1813314 1814114 1813751 o EL

chr3 1821574 1822707 1822082 o o EE ORIc11

chr3 1836995 1837792 1837511 o o EE nmt1

chr3 1843926 1844821 1844316 o o EE

chr3 1846753 1847005 1846835 o o EE AT3057

chr3 1866250 1867421 1866846 o o EE

chr3 1877502 1878080 1877732 LL

chr3 1922590 1923374 1922928 o EL

chr3 1928104 1929303 1928792 o o EE

chr3 1934607 1935508 1935076 o o EE

chr3 1964914 1965601 1965259 o o EE

chr3 1967641 1969060 1968559 o o EE

chr3 1973736 1974774 1974024 o o EE

chr3 1999728 2000837 2000430 LL

chr3 2010786 2011183 2011004 LL pARS744

chr3 2022313 2022710 2022455 LL

chr3 2023453 2023899 2023583 LL

chr3 2034555 2036009 2035188 o o EE

chr3 2036857 2037444 2037163 o o EE

chr3 2045059 2046173 2045597 o o EE

chr3 2063067 2063984 2063549 o o EE

chr3 2066807 2067927 2067179 o o EE

chr3 2071630 2072049 2071906 o o EE

chr3 2078899 2079215 2078983 LL

chr3 2100680 2100879 2100741 LL

chr3 2106322 2107863 2106987 o o EE

chr3 2116480 2117063 2116832 LL

chr3 2134457 2134647 2134581 LL

chr3 2137199 2137701 2137440 o EL

chr3 2139356 2140083 2139715 o EL

chr3 2151908 2152477 2152164 LL

chr3 2158442 2158739 2158570 o EL

chr3 2159075 2159245 2159075 LL

chr3 2170052 2171082 2170186 LL

chr3 2200092 2201484 2201068 o o EE

chr3 2209224 2209829 2209545 LL

chr3 2218371 2218901 2218585 LL

chr3 2220323 2220937 2220736 o EL

chr3 2230940 2231403 2231167 LL

chr3 2256856 2257774 2257328 o o EE

chr3 2275234 2277786 2276043 o o EE

chr3 2290463 2290837 2290589 LL

chr3 2299245 2300667 2300152 o o EE

chr3 2307955 2309003 2308478 o LE

chr3 2317779 2317990 2317936 LL

chr3 2328339 2328863 2328631 LL

chr3 2335469 2336741 2336090 o o EE

chr3 2363022 2364381 2363857 o EL

chr3 2376144 2376325 2376283 o EL

chr3 2380523 2382740 2382358 o o EE

chr3 2391587 2391991 2391649 LL

chr3 2412157 2412303 2412255 LL

chr3 2418289 2418709 2418494 o EL

chr3 2419529 2420327 2419914 o o EE

chr3 2427884 2429245 2428381 o o EE

Table S3

Chromsome start end motif sequence motif start motif sequence motif start nearest origin type

LCS-like LCS

chr1 304184 304339 CCACGTGGGGG 304403 LE

chr1 454369 456655 CTATGTGGGGG,CCAAGTGGGGG,CTACGTGGGGG 457993,457818,457905 AGTGGGGGAT,TTCCCCCCAC 455534,455693 LL

chr1 783840 784222 CTATGTGGGGG 784297 LL

chr1 934134 934655 CTATGTGGGGG,CAAAATGGGGG 934719,935012 LL

chr1 1150056 1151153 CCAAGTGGGGG,CCGAGTGGGGG 1151622,1152113 LE

chr1 1293547 1294471 CTGAGTGGGGG 1295106 LL

chr1 1599754 1600838 CCAAGTGGGGG,CTGTGTGGGGG 1601298,1601356 LE

chr1 1951374 1952173 CTATGTGGGGG,CCTTGTGGGGG 1952635,1952505 LE

chr1 2326242 2326598 CAAAGTGGGGG 2326879 LE

chr1 2405568 2406616 CCATGTGGGGG,CTTTGTGGGGG 2407146,2407075 LE

chr1 2662706 2665214 CAATGTGGGGG,CGATGTGGGGG 2666263,2666342 GTGGGGGGAT,GTGGGGGGAA 2663758,2663837 LE

chr1 2689307 2689654 CTATATGGGGG,CCAAATGGGGG 2689933,2689839 LL

chr1 2876182 2877256 CGAAGTGGGGG,CCGAGTGGGGG 2877795,2878026 LE

chr1 3157612 3158546 CTATGTGGGGG 3158966 LE

chr1 4360232 4361166 CTAAGTGGGGG 4361585 LL

chr1 4456189 4457522 CTATGTGGGGG,CAAAGTGGGGG,CCTTATGGGGG 4458396,4458278,4458297 AGTGGGGGAT 4456947 LE

chr1 4705750 4706519 CAATGTGGGGG 4706861 LE

chr1 4787273 4788971 CTATGTGGGGG,CTGAATGGGGG,CTACGTGGGGG 4789684,4789549,4789604 LL

chr1 5298520 5298684 CTATGTGGGGG,CTATGTGGGGG 5298823,5298741 LL

chr2 227681 228487 CGTTGTGGGGG 228966 LL

chr2 891155 891742 CTTAGTGGGGG,CTCAGTGGGGG 892038,891922 LE

chr2 1079670 1080305 CCATGTGGGGG,CCAAGTGGGGG 1080770,1080700 LE

chr2 2113240 2113716 CTAAGTGGGGG,CCAAATGGGGG 2114000,2114071 AGTGGGGGAT 2113526 LE

chr2 2584715 2588572 CTATGTGGGGG 2589042 LE

chr2 2647377 2647594 CCAAGTGGGGG 2647595 LE

chr2 3008070 3009060 CAAAGTGGGGG 3009803 LE

chr2 3155123 3155724 CTAAGTGGGGG 3155975 AGTGGGGGAT 3155376 LE

chr2 3379967 3380826 CCTTGTGGGGG 3381484 TTCCCCCCCC,TTCCCCCACC,GTGGGGGGAT 3380518,3380539,3380628 LE

chr2 3573655 3575163 ATCCCCCACT 3574523 LL

chr2 3702549 3703517 CAAAGTGGGGG,CTAAATGGGGG 3703810,3703900 LL

chr2 4252751 4256457 CTATGTGGGGG,CTAAGTGGGGG 4259434,4259495 ATCCCCCACT 4255776 LL

chr3 2309401 2310162 CTATGTGGGGG,CTATGTGGGGG 2310626,2310544 LE

Genes & Developmentgenesdev.cshlp.org/content/suppl/2012/01/25/26.2... · 3500 3520 3540 3560 3580-4 4 4 2 0-2 3500 3520 3540 3560 3580 4 2 0-2-4 spac16e8.01 spac16e8.02 spgna1 spac16e8.04c

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