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Gene Regulation: Eukaryotes• Levels of Control• Genome Differences:
Prokaryote vs Eukaryote• Gene Regulation• Gene Dosage • Gene Amplification • Heterochromatin and DNA
methylation• Transcriptional Factors• Differential processing • Translational control
Levels of Control
• Transcriptional Control
• Processing • Transport • Translational Control • Ex: Globin synthesis
Genome Differences: Prokaryote vs Eukaryote
• monocistronic (though some nematodes have polygenic mRNA)
• exons and introns• histones and packaging • no simultaneous
transcription and translation
• Gene Dosage • Gene Amplification
Heterochromatin and DNA methylation
•Xic (1 Mb in length) and Xist (lacks an ORF)•Not translated•RNA product•Coats chromosome•Counting?•Progeny cells?