Gene expression profiling of liver from GSD1a patients: evidence of an inflammatory process The world of “omics” International meeting Glycogen Storage Diseases International meeting Glycogen Storage Diseases associations associations Milan October 2 Milan October 2 nd nd 2010 2010 Luigi Varesio
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Gene expression profiling of liver from GSD1a patients: evidence of an inflammatory process The world of omics International meeting Glycogen Storage Diseases.
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Gene expression profiling of liver from GSD1a patients: evidence of an inflammatory process
The world of
“omics”
International meeting Glycogen Storage Diseases associationsInternational meeting Glycogen Storage Diseases associationsMilan October 2Milan October 2ndnd 2010 2010
Luigi VaresioLuigi Varesio
54000 probsets54000 probsets
The chipThe chip
Gene expression Gene expression profile of GSD1a profile of GSD1a
liverliver
Gene expression profile of the liver of three patients who underwent liver transplantation and of three normal tissues.
Data analysis with Bibliosphere (Genomatics) to study metabolic pathways.
Gene expression profile of the liver of three patients who underwent liver transplantation and of three normal tissues.
Data analysis with Bibliosphere (Genomatics) to study metabolic pathways.
Complicationslack of gowthdelay of pubertygout juvenilepancreatitisarteriosclerosishepatomashypertensionadenomaskidney diseases
sugars
fats
proteins
G6PaseG6Pase
InflammationInflammation
CytokinesIL-6, IL-8
Hypoxia in patho-physiological processesHypoxia in patho-physiological processesHypoxia in patho-physiological processesHypoxia in patho-physiological processes
HYPOXIA(pO2 0-20mm Hg)
Growing tumors
Cerebral ischemia Myocardial ischemia
Pulmonary hypertension
Rheumatoid arthritis
Diabetic retinopathy
Wound healing
PreeclampsiaIntrauterine growth
retardation
Energy metabolism
Cell proliferation/survival
Angiogenesis Cell survival
Cell migrationErytropoiesis
Microbial infections
Aherosclerosis
Hypoxia in the liver of GSD1a patients Hypoxia in the liver of GSD1a patients Hypoxia in the liver of GSD1a patients Hypoxia in the liver of GSD1a patients