CLINICALRESEARCH
TRANSLATIONAL RESEARCH
Genomics & Proteomics
Bioprocessing
Chemical Synthesis
BIOTECHNOLOGYHEALTHCARESERVICES & DELIVERY
Molecular & Cell Biology
Bioengineering &Nanotechnology
Computational Biology
Industry Sectors
Industry Sectors
Bioimaging
Cohort Studies
Biomarkers
Stem
cells
Drug D
iscove
ryPHARMACEUTICALS MEDICAL TECHNOLOGY
Biomedical Cluster Map
MEaT = Medical Enginering and TechnologyIMCB = Institute of Molecular & Cell BiologyGIS = Genome Institute of SingaporeBTI = Bioprocessing Technical InstituteIBN = Institute of Bioengineering and NanotechnologyBII = Bioinformatics InstituteCMM = Centre for Molecular MedicineSICS = Singapore Institute for Clinical SciencesSBIC = Singapore Bioimaging Consortium
SIgN = Singapore Immunology NetworkSSCC = Singapore Stem Cell Consortium STN = Singapore Tissue NetworkSCS = Singapore Cancer SyndicateSCCS = Singapore Consortium of Cohort StudiesDPF = Data Privacy FrameworkBMS IF = Biomedical International FellowshipCSI = Clincian Scientist InvestigatorshipIRBs = Institutional Review Boards
Mission-oriented BENCH
INDUSTRY
Co-investment, VC funding
RISC grants, infrastructure, tax breaks
Pharma MEaT Biotech
Biologics (c
ells / v
accines)
Med tech
/ devic
es
Drug discove
ry & devt
Singapore Clinical Trials
• IMCB, GIS, BTI• IBN, BII, • CMM, SICS
Research Institutes
• SBIC• SSCC
• SIgN• Biomarkers
Research Consortia
Set up by A*STAR / BMRC
BEDSIDE
Clinical Research Programmes• Focus, strategyHuman Capital• Development, recruitment
Infrastructure• For Clinical Trials
Regulatory Framework• IRBs
DPF Office
MBBS PhD / BMS IF / CSI awards
Translational / Investigational
Medicine NMRC / HSA
Clinical Trials Overseas Clinical Trials
STNSCS
SCCS
Academic BENCH
NUS, NTU
ClinicalBIOMEDICAL RESEARCH
TranslationalBasic
Singapore Health Services• Singapore General Hospital• National Cancer Centre• National Heart Centre• Singapore National Eye Centre• KK Women and Children’s Hospital• National Neuroscience Institute
National Healthcare Group• National University Hospital• The Cancer Institute• Tan Tock Seng Hospital• Communicable Disease Centre• National Skin Centre
Extramural Grants
− Singapore Cancer Syndicate− Singapore Bioimaging
Consortium − Singapore Stem Cell
Consortium− Singapore Immunology
Network− Member of Intl Cancer
Biomarker Consortium
Singapore Institute for Clinical Sciences (SICS)
• Develop programmes in Translational Clinical Medicine
• Develop critical resources:- Singapore Tissue Network- Singapore Consortium of
Cohort Studies
• Develop Clinician Scientists:- Clinician Scientist
Investigatorship (CSI) Awards- PhD training for medical
doctors- Biomedical International
Fellowships
Ministry of Health HQ- Ethical regulations/framework for
clinical research e.g. IRBs
National Medical Research Council- Clinical research strategy- Grant management- Manpower development
Health Sciences Authority- Evaluation capabilities for new
technologies
Research Institutes
• Institute of Molecular & Cell Biology
• Genome Institute of Singapore
• Institute of Bioengineering & Nanotechnology
• Bioprocessing Technology Institute
• Bioinformatics Institute
UNIVERSITIES
Institute of Medicinal Biology (IMB)
− Singapore Oncogenome Group− Regenerative Medicine− Epithelial Biology
Consortia
SICS @ Kent Ridge- Genetic Medicine- Virology/Infectious Diseases
SICS @ Outram(2008-2010)− Cardiovascular Diseases− Eye Diseases
A*STAR Biomedical Research Council Ministry Of Health
Bench to Bedside to Industry Cycle
PHARMAINDUSTRY
BENCHKey performers:
research institutes, universities
BEDSIDEKey performers:
hospitals, specialist centres
Grow health services, public health research
Build critical mass of human capital , supernumerary to clinical service needs
Establish flagship programmes from bench-to-bedside (heart/ metabolic, neuro, cancer, eye, infectious disease)
Interaction strengthened by new entities arising from hospital-medical school partnerships
Develop strong investigational med capability
Be preferred site for early phase
clinical trials in Asia
Individual Research Grants
Exploratory/ Developmental Grants
Translational & Clinical Research Grant
Programmatic Grants
Strategic/ Programmatic
Investigator-led Research
Research Grants[Support research projects/ programmes]
Overall Grant/ Support Framework
Infrastructure[Devt support]
Strategic Research Infra[Research building, investigational med unit, animal facility]
Academic Research Organisation
Singapore Translational Research Investigatorship
Clinician Scientist Award
Talent Support[Salary support + research grants]
Incr
easi
ng s
enio
rity
and
supp
ort
Healthcare Research Scholarship
Development of Translational/Clinical Research (TCR ) Human Capital
A new pool of physicians scientists freed of clinical service obligations
Singapore Translational Research Investigatorship Award.
International and Singaporean Senior Physician Scientist awards
(15 per year)Similar to Howard Hughes Medical Institute award –
full salary and lab support for 5 years)
Clinician Scientist Award.
Young Singapore Physician Scientist awards (70 per year)
Full salary and an internationally competitive research grant for 3 years
Bench to Bedside Research Funding Programs
Funds for teams of basic and clinical scientists
Translational/Clinical Research (TCR) flagship Awards
Targeted research programs in each of the following therapeutic areas: cancer, neuroscience, cardiovascular/
metabolism, infectious diseases, opthalmology –
S$25 M over 5 years for each program
Infrastructure to support TCR
*Academic Medical CentersAMCs established through union of
medical school and tertiary hospital under a common governance
*Investigational Medicine UnitsClinical research units (2)
for early in man clinical investigation – S$20 M each
*Singapore Clinical Research InstituteTrans-Singapore clinical research
organisations to support therapeutic trials sponsored by pharmaceutical companies
– S$6 M per annum
Institute of Medical Biology (IMB)
Executive Director: Prof Birgit Lane
IMB studies the mechanisms of human disease in order to discovernew and effective therapeutic strategies for an improved quality of life.
Translational ResearchFrom Bench to Bedside
Research Areas:• Singapore Oncogenome Project• Papilloma Virology• Epithelial Biology• Developmental and Regenerative
Biology• Regenerative Medicine• Stem Cell Biology• Mesenchymal Stem Cells
Singapore Institute for Clinical Sciences (SICS)
Executive Director: Prof Judith Swain
Using innovative approaches and technologies to enable the efficient and effective study of human health and diseases
Translational ResearchFrom Bench to Bedside
Research Areas:• Genetic Medicine• Hepatic Diseases• Metabolic Diseases
SICS is headquartered at Biopolis, with labs both at: • The Brenner Centre for Molecular Medicine • Nanos @ Biopolis
Experimental Therapeutics Centre (ETC)
Chief Executive Officer: Prof Sir David Lane
Translational ResearchFrom Bench to Bedside
• Build up capabilities and resources required for early stage drug discovery and development
• Help advance the drug candidates to a stage that is considered commercially more attractive to industry
2001
Dr Edison LiuExecutive Director,
GIS
2002
Dr Yoshiaki ItoPI, IMCB
2003 2004 2005 2006
Sir David LaneExecutive Director, IMCB & Executive
Dy Chmn (BSTG), BMRC
Dr Birgitte LaneExecutive
Director, IMB
Dr Neal Copeland & Dr Nancy Jenkins
PIs, IMCB
Dr Phil InghamPI, IMCB
Dr Jean Paul Thiery
PI, IMCB
Dr Edward HolmesExecutive Dy Chmn
(TCSG), BMRC & Chmn, NMRC
Dr Judith Swain
Executive Director, SICS
Dr Philippe KourilskyChairman, SIgN
Dr Axel UllrichDirector, SOG Lab
Sir George RaddaChairman, SBIC
Dr Jackie YingExecutive
Director, IBN
When physician-scientists Judith Swain and Ed Holmes take up their posts in Singapore…, they will join a star-studded community at one of the world’s most rapidly developing biomedical research centres. …they are the latest of many Western scientists who have headed for the impressive facilities of the tiny city-state.
Naturejobs, 5 Jul 06
Attracting International Talent (Whales)
MITPhysics
(Malaysia)
Human Capital: International Guppies
StanfordChemical Engineering
(Shanghai)
MITBio Engineering
(Hong Kong)
MITChemical Engineering
(Germany)
StanfordComputer Science
(India)
MITChemical Engineering
(Vietnam)
RockefellerBacteriology
Human Capital: Singapore Guppies
StanfordBiochemistry
StanfordBiochemistry
Medicine/PhDDuke
Medicine/PhDCamrbidge, London
Computer ScienceCarnegie-Mellon
NSS(BS) - 3 yrs
231*AGS - 4 yrs
193 at partner
universities
NSS(PhD) - 4-5 yrs
193**
overseas72 Completed
PhDs***
Nurturing & Developing Human Capital689 Potential and Completed PhDs
IFCorrect as at 24th September 2007*Of which, 68 BS and 1 MBBS are NSFs.**Includes 1 GMS (MD-PhD) scholar.***Includes scholars who are currently attached pending PhD conferment (NUS & NTU takes up to 9 months for conferment.)
458
Completed